| Year |
Citation |
Score |
| 2023 |
Bonica J, Clarke CJ, Obeid LM, Luberto C, Hannun YA. Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 37: e22787. PMID 36723905 DOI: 10.1096/fj.202201066R |
0.395 |
|
| 2021 |
Truman JP, Ruiz CF, Montal E, Garcia-Barros M, Mileva I, Snider AJ, Hannun YA, Obeid LM, Mao C. 1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase. Journal of Lipid Research. 63: 100154. PMID 34838542 DOI: 10.1016/j.jlr.2021.100154 |
0.379 |
|
| 2021 |
Truman JP, Ruiz CF, Trayssac M, Mao C, Hannun YA, Obeid LM. Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21284. PMID 33484475 DOI: 10.1096/fj.202001814RR |
0.42 |
|
| 2021 |
Trayssac M, Clarke CJ, Stith JL, Snider JM, Newen N, Gault CR, Hannun YA, Obeid LM. Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Cell Death & Disease. 12: 27. PMID 33414460 DOI: 10.1038/s41419-020-03281-4 |
0.75 |
|
| 2020 |
Bonica J, Mao C, Obeid LM, Hannun YA. Transcriptional Regulation of Sphingosine Kinase 1. Cells. 9. PMID 33171624 DOI: 10.3390/cells9112437 |
0.341 |
|
| 2020 |
Raquib R, Hernández-Corbacho MJ, Obeid LM. Abstract B095: Tackling chemotherapy resistance of cancer cells: Inhibition of diacylglycerol O-acyltransferase 2 increases ceramide and cancer cell apoptosis Cancer Epidemiology, Biomarkers & Prevention. DOI: 10.1158/1538-7755.Disp19-B095 |
0.325 |
|
| 2018 |
Pulkoski-Gross MJ, Obeid LM. Molecular mechanisms of regulation of sphingosine kinase 1. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 1863: 1413-1422. PMID 30591148 DOI: 10.1016/j.bbalip.2018.08.015 |
0.377 |
|
| 2018 |
Sakamoto W, Coant N, Canals D, Obeid LM, Hannun YA. Functions of neutral ceramidase in the Golgi apparatus. Journal of Lipid Research. PMID 30154232 DOI: 10.1194/Jlr.M088187 |
0.354 |
|
| 2018 |
Newcomb B, Rhein C, Mileva I, Ahmad R, Clarke CJ, Snider J, Obeid LM, Hannun YA. Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5. Journal of Lipid Research. PMID 29724781 DOI: 10.1194/jlr.M084202 |
0.335 |
|
| 2018 |
Coant N, García-Barros M, Zhang Q, Obeid LM, Hannun YA. AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. PMID 29662189 DOI: 10.1038/s41388-018-0236-x |
0.385 |
|
| 2018 |
Carroll BL, Bonica J, Shamseddine AA, Hannun YA, Obeid LM. A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway. Febs Open Bio. 8: 27-40. PMID 29321954 DOI: 10.1002/2211-5463.12344 |
0.383 |
|
| 2017 |
Xu R, Garcia-Barros M, Wen S, Li F, Lin CL, Hannun YA, Obeid LM, Mao C. Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death and Differentiation. PMID 29229990 DOI: 10.1038/s41418-017-0018-y |
0.363 |
|
| 2017 |
Liu M, Clarke CJ, Salama MF, Choi YJ, Obeid LM, Hannun YA. Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation. Plos One. 12: e0184818. PMID 28926616 DOI: 10.1371/journal.pone.0184818 |
0.37 |
|
| 2016 |
García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA. Role of neutral ceramidase in colon cancer. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27609772 DOI: 10.1096/Fj.201600611R |
0.302 |
|
| 2016 |
Carroll BL, Pulkoski-Gross MJ, Hannun YA, Obeid LM. CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles. Oncotarget. PMID 26921248 DOI: 10.18632/oncotarget.7566 |
0.326 |
|
| 2016 |
Sundaram K, Mather AR, Marimuthu S, Shah PP, Snider AJ, Obeid LM, Hannun YA, Beverly LJ, Siskind LJ. Loss of neutral ceramidase protects cells from nutrient and energy deprivation-induced cell death. The Biochemical Journal. PMID 26747710 DOI: 10.1042/BJ20150586 |
0.331 |
|
| 2015 |
Hernández-Corbacho MJ, Canals D, Adada MM, Liu M, Senkal CE, Yi JK, Mao C, Luberto C, Hannun YA, Obeid LM. Tumor Necrosis Factor alpha (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. The Journal of Biological Chemistry. PMID 26318452 DOI: 10.1074/jbc.M115.658658 |
0.38 |
|
| 2015 |
Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM. Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 4654-69. PMID 26209696 DOI: 10.1096/fj.15-274340 |
0.419 |
|
| 2015 |
Pulkoski-Gross MJ, Donaldson JC, Obeid LM. Sphingosine-1-phosphate metabolism: A structural perspective. Critical Reviews in Biochemistry and Molecular Biology. 50: 298-313. PMID 25923252 DOI: 10.3109/10409238.2015.1039115 |
0.324 |
|
| 2015 |
Salama MF, Carroll B, Adada M, Pulkoski-Gross M, Hannun YA, Obeid LM. A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2803-13. PMID 25805832 DOI: 10.1096/fj.15-270413 |
0.344 |
|
| 2014 |
El Osta M, Liu M, Adada M, Senkal CE, Idkowiak-Baldys J, Obeid LM, Clarke CJ, Hannun YA. Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 495-505. PMID 24121461 DOI: 10.1096/Fj.13-230557 |
0.48 |
|
| 2014 |
Adada M, Canals D, Hannun YA, Obeid LM. Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics. Biochimica Et Biophysica Acta. 1841: 727-37. PMID 23850862 DOI: 10.1016/j.bbalip.2013.07.002 |
0.381 |
|
| 2013 |
Adada MM, Orr-Gandy KA, Snider AJ, Canals D, Hannun YA, Obeid LM, Clarke CJ. Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation. The Journal of Biological Chemistry. 288: 27667-79. PMID 23935096 DOI: 10.1074/jbc.M113.489443 |
0.348 |
|
| 2013 |
Orr Gandy KA, Adada M, Canals D, Carroll B, Roddy P, Hannun YA, Obeid LM. Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3155-66. PMID 23629860 DOI: 10.1096/Fj.13-228460 |
0.79 |
|
| 2013 |
Gandy KA, Obeid LM. Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway. Handbook of Experimental Pharmacology. 275-303. PMID 23563662 DOI: 10.1007/978-3-7091-1511-4_14 |
0.322 |
|
| 2013 |
Snider AJ, Ruiz P, Obeid LM, Oates JC. Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis. Plos One. 8: e53521. PMID 23301082 DOI: 10.1371/Journal.Pone.0053521 |
0.414 |
|
| 2013 |
Heffernan-Stroud LA, Obeid LM. Sphingosine kinase 1 in cancer. Advances in Cancer Research. 117: 201-35. PMID 23290781 DOI: 10.1016/B978-0-12-394274-6.00007-8 |
0.8 |
|
| 2013 |
Furuya H, Wada M, Shimizu Y, Yamada PM, Hannun YA, Obeid LM, Kawamori T. Effect of sphingosine kinase 1 inhibition on blood pressure. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 656-64. PMID 23109673 DOI: 10.1096/Fj.12-219014 |
0.443 |
|
| 2013 |
Gandy KA, Canals D, Adada M, Wada M, Roddy P, Snider AJ, Hannun YA, Obeid LM. Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. The Biochemical Journal. 449: 661-72. PMID 23106337 DOI: 10.1042/BJ20120213 |
0.328 |
|
| 2013 |
Orr Gandy KA, Obeid LM. Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors. Biochimica Et Biophysica Acta. 1831: 157-66. PMID 22801037 DOI: 10.1016/j.bbalip.2012.07.002 |
0.794 |
|
| 2012 |
Snider AJ, Wu BX, Jenkins RW, Sticca JA, Kawamori T, Hannun YA, Obeid LM. Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. Prostaglandins & Other Lipid Mediators. 99: 124-30. PMID 22940715 DOI: 10.1016/J.Prostaglandins.2012.08.003 |
0.378 |
|
| 2012 |
Gault CR, Eblen ST, Neumann CA, Hannun YA, Obeid LM. Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. The Journal of Biological Chemistry. 287: 31794-803. PMID 22833671 DOI: 10.1074/Jbc.M112.385765 |
0.781 |
|
| 2012 |
Ponnusamy S, Selvam SP, Mehrotra S, Kawamori T, Snider AJ, Obeid LM, Shao Y, Sabbadini R, Ogretmen B. Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. Embo Molecular Medicine. 4: 761-75. PMID 22707406 DOI: 10.1002/Emmm.201200244 |
0.426 |
|
| 2012 |
Chipuk JE, McStay GP, Bharti A, Kuwana T, Clarke CJ, Siskind LJ, Obeid LM, Green DR. Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell. 148: 988-1000. PMID 22385963 DOI: 10.1016/J.Cell.2012.01.038 |
0.362 |
|
| 2012 |
Spassieva SD, Rahmaniyan M, Bielawski J, Clarke CJ, Kraveka JM, Obeid LM. Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells. Journal of Lipid Research. 53: 918-28. PMID 22377532 DOI: 10.1194/Jlr.M019075 |
0.413 |
|
| 2012 |
Mullen TD, Hannun YA, Obeid LM. Ceramide synthases at the centre of sphingolipid metabolism and biology. The Biochemical Journal. 441: 789-802. PMID 22248339 DOI: 10.1042/Bj20111626 |
0.42 |
|
| 2012 |
Lee AJ, Roylance R, Sander J, Gorman P, Endesfelder D, Kschischo M, Jones NP, East P, Nicke B, Spassieva S, Obeid LM, Birkbak NJ, Szallasi Z, McKnight NC, Rowan AJ, et al. CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction. The Journal of Pathology. 226: 482-94. PMID 21953249 DOI: 10.1002/Path.2998 |
0.364 |
|
| 2012 |
Heffernan-Stroud LA, Helke KL, Jenkins RW, De Costa AM, Hannun YA, Obeid LM. Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene. 31: 1166-75. PMID 21765468 DOI: 10.1038/Onc.2011.302 |
0.782 |
|
| 2012 |
Mullen TD, Obeid LM. Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death. Anti-Cancer Agents in Medicinal Chemistry. 12: 340-63. PMID 21707511 DOI: 10.2174/187152012800228661 |
0.396 |
|
| 2011 |
El-Shewy HM, Abdel-Samie SA, Al Qalam AM, Lee MH, Kitatani K, Anelli V, Jaffa AA, Obeid LM, Luttrell LM. Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. Molecular Endocrinology (Baltimore, Md.). 25: 2144-56. PMID 22016563 DOI: 10.1210/Me.2011-0101 |
0.625 |
|
| 2011 |
Devlin CM, Lahm T, Hubbard WC, Van Demark M, Wang KC, Wu X, Bielawska A, Obeid LM, Ivan M, Petrache I. Dihydroceramide-based response to hypoxia. The Journal of Biological Chemistry. 286: 38069-78. PMID 21914808 DOI: 10.1074/Jbc.M111.297994 |
0.363 |
|
| 2011 |
Baker DA, Obeid LM, Gilkeson GS. Impact of sphingosine kinase on inflammatory pathways in fibroblast-like synoviocytes. Inflammation & Allergy Drug Targets. 10: 464-71. PMID 21864273 DOI: 10.2174/187152811798104863 |
0.422 |
|
| 2011 |
Gault CR, Obeid LM. Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. Critical Reviews in Biochemistry and Molecular Biology. 46: 342-51. PMID 21787121 DOI: 10.3109/10409238.2011.597737 |
0.777 |
|
| 2011 |
Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. Plos Genetics. 7: e1002063. PMID 21625621 DOI: 10.1371/Journal.Pgen.1002063 |
0.36 |
|
| 2011 |
Novgorodov SA, Wu BX, Gudz TI, Bielawski J, Ovchinnikova TV, Hannun YA, Obeid LM. Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. The Journal of Biological Chemistry. 286: 25352-62. PMID 21613224 DOI: 10.1074/Jbc.M110.214866 |
0.326 |
|
| 2011 |
Doyle T, Chen Z, Obeid LM, Salvemini D. Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia. Neuroscience Letters. 499: 4-8. PMID 21605625 DOI: 10.1016/J.Neulet.2011.05.018 |
0.438 |
|
| 2011 |
Rahmaniyan M, Curley RW, Obeid LM, Hannun YA, Kraveka JM. Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. The Journal of Biological Chemistry. 286: 24754-64. PMID 21543327 DOI: 10.1074/Jbc.M111.250779 |
0.342 |
|
| 2011 |
Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, et al. Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 117: 5941-52. PMID 21527515 DOI: 10.1182/Blood-2010-08-300772 |
0.772 |
|
| 2011 |
Mullen TD, Jenkins RW, Clarke CJ, Bielawski J, Hannun YA, Obeid LM. Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. The Journal of Biological Chemistry. 286: 15929-42. PMID 21388949 DOI: 10.1074/Jbc.M111.230870 |
0.432 |
|
| 2011 |
Jenkins RW, Clarke CJ, Canals D, Snider AJ, Gault CR, Heffernan-Stroud L, Wu BX, Simbari F, Roddy P, Kitatani K, Obeid LM, Hannun YA. Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. The Journal of Biological Chemistry. 286: 13292-303. PMID 21335555 DOI: 10.1074/Jbc.M110.163378 |
0.77 |
|
| 2011 |
Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T. A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.). 4: 454-62. PMID 21209394 DOI: 10.1158/1940-6207.Capr-10-0299 |
0.458 |
|
| 2011 |
Novgorodov SA, Chudakova DA, Wheeler BW, Bielawski J, Kindy MS, Obeid LM, Gudz TI. Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis. The Journal of Biological Chemistry. 286: 4644-58. PMID 21148554 DOI: 10.1074/Jbc.M110.164392 |
0.356 |
|
| 2011 |
Hou Q, Jin J, Zhou H, Novgorodov SA, Bielawska A, Szulc ZM, Hannun YA, Obeid LM, Hsu YT. Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. Journal of Lipid Research. 52: 278-88. PMID 21081756 DOI: 10.1194/Jlr.M012161 |
0.392 |
|
| 2011 |
Heffernan-Stroud LA, Obeid LM. p53 and regulation of bioactive sphingolipids. Advances in Enzyme Regulation. 51: 219-28. PMID 21035490 DOI: 10.1016/J.Advenzreg.2010.10.003 |
0.78 |
|
| 2011 |
Mullen TD, Spassieva S, Jenkins RW, Kitatani K, Bielawski J, Hannun YA, Obeid LM. Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. Journal of Lipid Research. 52: 68-77. PMID 20940143 DOI: 10.1194/Jlr.M009142 |
0.397 |
|
| 2010 |
Gault CR, Obeid LM, Hannun YA. An overview of sphingolipid metabolism: from synthesis to breakdown. Advances in Experimental Medicine and Biology. 688: 1-23. PMID 20919643 DOI: 10.1007/978-1-4419-6741-1_1 |
0.757 |
|
| 2010 |
Canals D, Jenkins RW, Roddy P, Hernández-Corbacho MJ, Obeid LM, Hannun YA. Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. The Journal of Biological Chemistry. 285: 32476-85. PMID 20679347 DOI: 10.1074/Jbc.M110.141028 |
0.4 |
|
| 2010 |
Baker DA, Barth J, Chang R, Obeid LM, Gilkeson GS. Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. Journal of Immunology (Baltimore, Md. : 1950). 185: 2570-9. PMID 20644167 DOI: 10.4049/Jimmunol.1000644 |
0.332 |
|
| 2010 |
Mao Z, Sun W, Xu R, Novgorodov S, Szulc ZM, Bielawski J, Obeid LM, Mao C. Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells. The Journal of Biological Chemistry. 285: 29078-90. PMID 20628055 DOI: 10.1074/Jbc.M110.105296 |
0.438 |
|
| 2010 |
Anelli V, Gault CR, Snider AJ, Obeid LM. Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2727-38. PMID 20335228 DOI: 10.1096/Fj.09-150540 |
0.791 |
|
| 2010 |
Suhaiman L, De Blas GA, Obeid LM, Darszon A, Mayorga LS, Belmonte SA. Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosis. The Journal of Biological Chemistry. 285: 16302-14. PMID 20236935 DOI: 10.1074/Jbc.M109.072439 |
0.447 |
|
| 2010 |
Siskind LJ, Mullen TD, Romero Rosales K, Clarke CJ, Hernandez-Corbacho MJ, Edinger AL, Obeid LM. The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis. The Journal of Biological Chemistry. 285: 11818-26. PMID 20172858 DOI: 10.1074/Jbc.M109.078121 |
0.418 |
|
| 2010 |
Snider AJ, Orr Gandy KA, Obeid LM. Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation. Biochimie. 92: 707-15. PMID 20156522 DOI: 10.1016/J.Biochi.2010.02.008 |
0.779 |
|
| 2010 |
Sun W, Jin J, Xu R, Hu W, Szulc ZM, Bielawski J, Obeid LM, Mao C. Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2). The Journal of Biological Chemistry. 285: 8995-9007. PMID 20089856 DOI: 10.1074/Jbc.M109.069203 |
0.426 |
|
| 2010 |
Hu W, Xu R, Sun W, Szulc ZM, Bielawski J, Obeid LM, Mao C. Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. The Journal of Biological Chemistry. 285: 7964-76. PMID 20068046 DOI: 10.1074/Jbc.M109.063586 |
0.475 |
|
| 2010 |
Kawamori T, Furuya H, Wada M, Bielawski J, Hannun YA, Obeid LM. Abstract B80: Role for sphingosine kinase 1 in colon carcinogenesis Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-B80 |
0.442 |
|
| 2010 |
Shirai K, Furuya H, Wada M, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Kawamori T. Abstract 5656: Role for Sphingosine kinase 1 in head & neck cancer Cancer Research. 70: 5656-5656. DOI: 10.1158/1538-7445.Am10-5656 |
0.389 |
|
| 2009 |
Spassieva SD, Mullen TD, Townsend DM, Obeid LM. Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response. The Biochemical Journal. 424: 273-83. PMID 19728861 DOI: 10.1042/Bj20090699 |
0.468 |
|
| 2009 |
Jin J, Mullen TD, Hou Q, Bielawski J, Bielawska A, Zhang X, Obeid LM, Hannun YA, Hsu YT. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. Journal of Lipid Research. 50: 2389-97. PMID 19528633 DOI: 10.1194/Jlr.M900119-Jlr200 |
0.369 |
|
| 2009 |
Kitatani K, Sheldon K, Rajagopalan V, Anelli V, Jenkins RW, Sun Y, Grabowski GA, Obeid LM, Hannun YA. Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. The Journal of Biological Chemistry. 284: 12972-8. PMID 19279011 DOI: 10.1074/Jbc.M802790200 |
0.468 |
|
| 2009 |
Kitatani K, Sheldon K, Anelli V, Jenkins RW, Sun Y, Grabowski GA, Obeid LM, Hannun YA. Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. The Journal of Biological Chemistry. 284: 12979-88. PMID 19279008 DOI: 10.1074/Jbc.M809500200 |
0.421 |
|
| 2009 |
White-Gilbertson S, Mullen T, Senkal C, Lu P, Ogretmen B, Obeid L, Voelkel-Johnson C. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells Oncogene. 28: 1132-1141. PMID 19137010 DOI: 10.1038/Onc.2008.468 |
0.424 |
|
| 2009 |
Kawamori T, Kaneshiro T, Okumura M, Maalouf S, Uflacker A, Bielawski J, Hannun YA, Obeid LM. Role for sphingosine kinase 1 in colon carcinogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 405-14. PMID 18824518 DOI: 10.1096/fj.08-117572 |
0.336 |
|
| 2008 |
Zeidan YH, Jenkins RW, Korman JB, Liu X, Obeid LM, Norris JS, Hannun YA. Molecular targeting of acid ceramidase: implications to cancer therapy. Current Drug Targets. 9: 653-61. PMID 18691012 DOI: 10.2174/138945008785132358 |
0.374 |
|
| 2008 |
Jin J, Hou Q, Mullen TD, Zeidan YH, Bielawski J, Kraveka JM, Bielawska A, Obeid LM, Hannun YA, Hsu YT. Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. The Journal of Biological Chemistry. 283: 26509-17. PMID 18676372 DOI: 10.1074/Jbc.M801597200 |
0.414 |
|
| 2008 |
Mao C, Obeid LM. Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochimica Et Biophysica Acta. 1781: 424-34. PMID 18619555 DOI: 10.1016/J.Bbalip.2008.06.002 |
0.48 |
|
| 2008 |
Novgorodov SA, Gudz TI, Obeid LM. Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore. The Journal of Biological Chemistry. 283: 24707-17. PMID 18596045 DOI: 10.1074/Jbc.M801810200 |
0.331 |
|
| 2008 |
Panjarian S, Kozhaya L, Arayssi S, Yehia M, Bielawski J, Bielawska A, Usta J, Hannun YA, Obeid LM, Dbaibo GS. De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins & Other Lipid Mediators. 86: 41-8. PMID 18400537 DOI: 10.1016/J.Prostaglandins.2008.02.004 |
0.5 |
|
| 2008 |
Misra S, Obeid LM, Hannun YA, Minamisawa S, Berger FG, Markwald RR, Toole BP, Ghatak S. Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells Journal of Biological Chemistry. 283: 14335-14344. PMID 18326857 DOI: 10.1074/Jbc.M703811200 |
0.44 |
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| 2008 |
Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nature Reviews. Molecular Cell Biology. 9: 139-50. PMID 18216770 DOI: 10.1038/Nrm2329 |
0.449 |
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| 2008 |
Hammad SM, Crellin HG, Wu BX, Melton J, Anelli V, Obeid LM. Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages. Prostaglandins & Other Lipid Mediators. 85: 107-14. PMID 18166496 DOI: 10.1016/J.Prostaglandins.2007.11.002 |
0.415 |
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| 2008 |
Anelli V, Gault CR, Cheng AB, Obeid LM. Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. The Journal of Biological Chemistry. 283: 3365-75. PMID 18055454 DOI: 10.1074/Jbc.M708241200 |
0.778 |
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| 2008 |
Sun W, Xu R, Hu W, Jin J, Crellin HA, Bielawski J, Szulc ZM, Thiers BH, Obeid LM, Mao C. Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. The Journal of Investigative Dermatology. 128: 389-97. PMID 17713573 DOI: 10.1038/Sj.Jid.5701025 |
0.394 |
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| 2008 |
Zeidan YH, Wu BX, Jenkins RW, Obeid LM, Hannun YA. A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 183-93. PMID 17698617 DOI: 10.1096/fj.07-8967com |
0.337 |
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| 2007 |
Spassieva S, Bielawski J, Anelli V, Obeid LM. Combination of C(17) sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism. Methods in Enzymology. 434: 233-41. PMID 17954250 DOI: 10.1016/S0076-6879(07)34012-3 |
0.354 |
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| 2007 |
Saad AF, Meacham WD, Bai A, Anelli V, Elojeimy S, Mahdy AE, Turner LS, Cheng J, Bielawska A, Bielawski J, Keane TE, Obeid LM, Hannun YA, Norris JS, Liu X. The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biology & Therapy. 6: 1455-60. PMID 17881906 DOI: 10.4161/Cbt.6.9.4623 |
0.39 |
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| 2007 |
Kitagaki H, Cowart LA, Matmati N, Vaena de Avalos S, Novgorodov SA, Zeidan YH, Bielawski J, Obeid LM, Hannun YA. Isc1 regulates sphingolipid metabolism in yeast mitochondria. Biochimica Et Biophysica Acta. 1768: 2849-61. PMID 17880915 DOI: 10.1016/J.Bbamem.2007.07.019 |
0.328 |
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| 2007 |
El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM. The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. The Journal of Biological Chemistry. 282: 26150-7. PMID 17620336 DOI: 10.1074/Jbc.M703276200 |
0.56 |
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| 2007 |
Yu J, Novgorodov SA, Chudakova D, Zhu H, Bielawska A, Bielawski J, Obeid LM, Kindy MS, Gudz TI. JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction. The Journal of Biological Chemistry. 282: 25940-9. PMID 17609208 DOI: 10.1074/Jbc.M701812200 |
0.328 |
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| 2007 |
Kusner DJ, Thompson CR, Melrose NA, Pitson SM, Obeid LM, Iyer SS. The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. The Journal of Biological Chemistry. 282: 23147-62. PMID 17519232 DOI: 10.1074/Jbc.M700193200 |
0.337 |
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| 2007 |
Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM, Ogretmen B. Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. The Journal of Biological Chemistry. 282: 10922-34. PMID 17303574 DOI: 10.1074/Jbc.M610157200 |
0.439 |
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| 2007 |
Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A. Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. The Journal of Biological Chemistry. 282: 16718-28. PMID 17283068 DOI: 10.1074/Jbc.M700647200 |
0.44 |
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| 2007 |
Novgorodov AS, El-Alwani M, Bielawski J, Obeid LM, Gudz TI. Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 1503-14. PMID 17255471 DOI: 10.1096/fj.06-7420com |
0.3 |
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| 2007 |
Cowart LA, Obeid LM. Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function. Biochimica Et Biophysica Acta. 1771: 421-31. PMID 16997623 DOI: 10.1016/J.Bbalip.2006.08.005 |
0.429 |
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| 2007 |
Cowart LA, Hannun YA, Obeid LM. Metabolism and function of sphingolipids in saccharomyces cerevisiae: Relevance to cancer research Yeast as a Tool in Cancer Research. 191-210. DOI: 10.1007/978-1-4020-5963-6_8 |
0.393 |
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| 2006 |
Taha TA, Mullen TD, Obeid LM. A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochimica Et Biophysica Acta. 1758: 2027-36. PMID 17161984 DOI: 10.1016/j.bbamem.2006.10.018 |
0.325 |
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| 2006 |
Taha TA, El-Alwani M, Hannun YA, Obeid LM. Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease. Febs Letters. 580: 6047-54. PMID 17064696 DOI: 10.1016/J.Febslet.2006.09.070 |
0.3 |
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| 2006 |
Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA. Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. The Journal of Biological Chemistry. 281: 36793-802. PMID 17030510 DOI: 10.1074/Jbc.M608137200 |
0.465 |
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| 2006 |
Spassieva S, Seo JG, Jiang JC, Bielawski J, Alvarez-Vasquez F, Jazwinski SM, Hannun YA, Obeid LM. Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. The Journal of Biological Chemistry. 281: 33931-8. PMID 16951403 DOI: 10.1074/Jbc.M608092200 |
0.363 |
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| 2006 |
Xu R, Jin J, Hu W, Sun W, Bielawski J, Szulc Z, Taha T, Obeid LM, Mao C. Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1813-25. PMID 16940153 DOI: 10.1096/fj.05-5689com |
0.38 |
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| 2006 |
El-Shewy HM, Johnson KR, Lee MH, Jaffa AA, Obeid LM, Luttrell LM. Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. The Journal of Biological Chemistry. 281: 31399-407. PMID 16926156 DOI: 10.1074/Jbc.M605339200 |
0.63 |
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| 2006 |
Szulc ZM, Bielawski J, Gracz H, Gustilo M, Mayroo N, Hannun YA, Obeid LM, Bielawska A. Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorganic & Medicinal Chemistry. 14: 7083-104. PMID 16919460 DOI: 10.1016/J.Bmc.2006.07.016 |
0.364 |
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| 2006 |
Dindo D, Dahm F, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Graf R, Clavien PA. Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Molecular Cancer Therapeutics. 5: 1520-9. PMID 16818511 DOI: 10.1158/1535-7163.Mct-05-0513 |
0.347 |
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| 2006 |
Zeidan YH, Pettus BJ, Elojeimy S, Taha T, Obeid LM, Kawamori T, Norris JS, Hannun YA. Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. The Journal of Biological Chemistry. 281: 24695-703. PMID 16803890 DOI: 10.1074/Jbc.M604713200 |
0.442 |
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| 2006 |
El Alwani M, Wu BX, Obeid LM, Hannun YA. Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacology & Therapeutics. 112: 171-83. PMID 16759708 DOI: 10.1016/J.Pharmthera.2006.04.004 |
0.363 |
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| 2006 |
Taha TA, Hannun YA, Obeid LM. Sphingosine kinase: biochemical and cellular regulation and role in disease. Journal of Biochemistry and Molecular Biology. 39: 113-31. PMID 16584625 DOI: 10.5483/Bmbrep.2006.39.2.113 |
0.494 |
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| 2006 |
Fieber CB, Eldridge J, Taha TA, Obeid LM, Muise-Helmericks RC. Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells. Experimental Cell Research. 312: 1164-73. PMID 16527273 DOI: 10.1016/J.Yexcr.2006.01.022 |
0.445 |
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| 2006 |
Hammad SM, Taha TA, Nareika A, Johnson KR, Lopes-Virella MF, Obeid LM. Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells. Prostaglandins & Other Lipid Mediators. 79: 126-40. PMID 16516816 DOI: 10.1016/J.Prostaglandins.2005.12.004 |
0.406 |
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| 2006 |
Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 317: 1188-99. PMID 16510697 DOI: 10.1124/Jpet.106.101949 |
0.324 |
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| 2006 |
Taha TA, Kitatani K, El-Alwani M, Bielawski J, Hannun YA, Obeid LM. Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 482-4. PMID 16507765 DOI: 10.1096/Fj.05-4412Fje |
0.378 |
|
| 2006 |
Kawamori T, Osta W, Johnson KR, Pettus BJ, Bielawski J, Tanaka T, Wargovich MJ, Reddy BS, Hannun YA, Obeid LM, Zhou D. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 386-8. PMID 16319132 DOI: 10.1096/Fj.05-4331Fje |
0.447 |
|
| 2005 |
Bu S, Yamanaka M, Pei H, Bielawska A, Bielawski J, Hannun YA, Obeid L, Trojanowska M. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 184-6. PMID 16278291 DOI: 10.1096/Fj.05-4646Fje |
0.423 |
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| 2005 |
Stahelin RV, Hwang JH, Kim JH, Park ZY, Johnson KR, Obeid LM, Cho W. The mechanism of membrane targeting of human sphingosine kinase 1. The Journal of Biological Chemistry. 280: 43030-8. PMID 16243846 DOI: 10.1074/Jbc.M507574200 |
0.356 |
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| 2005 |
Pettus BJ, Kitatani K, Chalfant CE, Taha TA, Kawamori T, Bielawski J, Obeid LM, Hannun YA. The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Molecular Pharmacology. 68: 330-5. PMID 15900018 DOI: 10.1124/Mol.104.008722 |
0.414 |
|
| 2005 |
Thompson CR, Iyer SS, Melrose N, VanOosten R, Johnson K, Pitson SM, Obeid LM, Kusner DJ. Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 174: 3551-61. PMID 15749892 DOI: 10.4049/Jimmunol.174.6.3551 |
0.301 |
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| 2005 |
Novgorodov SA, Szulc ZM, Luberto C, Jones JA, Bielawski J, Bielawska A, Hannun YA, Obeid LM. Positively charged ceramide is a potent inducer of mitochondrial permeabilization. The Journal of Biological Chemistry. 280: 16096-105. PMID 15722351 DOI: 10.1074/Jbc.M411707200 |
0.31 |
|
| 2005 |
Taha TA, Kitatani K, Bielawski J, Cho W, Hannun YA, Obeid LM. Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. The Journal of Biological Chemistry. 280: 17196-202. PMID 15710602 DOI: 10.1074/Jbc.M413744200 |
0.426 |
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| 2005 |
Rossi MJ, Sundararaj K, Koybasi S, Phillips MS, Szulc ZM, Bielawska A, Day TA, Obeid LM, Hannun YA, Ogretmen B. Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 132: 55-62. PMID 15632910 DOI: 10.1016/J.Otohns.2004.08.015 |
0.35 |
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| 2005 |
Birbes H, Luberto C, Hsu YT, El Bawab S, Hannun YA, Obeid LM. A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. The Biochemical Journal. 386: 445-51. PMID 15516208 DOI: 10.1042/Bj20041627 |
0.308 |
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| 2004 |
Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. The Journal of Biological Chemistry. 279: 53994-4001. PMID 15485866 DOI: 10.1074/Jbc.M410144200 |
0.341 |
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| 2004 |
Argraves KM, Wilkerson BA, Argraves WS, Fleming PA, Obeid LM, Drake CJ. Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. The Journal of Biological Chemistry. 279: 50580-90. PMID 15377653 DOI: 10.1074/Jbc.M404432200 |
0.396 |
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| 2004 |
Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas Journal of Biological Chemistry. 279: 44311-44319. PMID 15317812 DOI: 10.1074/Jbc.M406920200 |
0.378 |
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| 2004 |
Taha TA, Argraves KM, Obeid LM. Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochimica Et Biophysica Acta. 1682: 48-55. PMID 15158755 DOI: 10.1016/J.Bbalip.2004.01.006 |
0.351 |
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| 2004 |
Sims KJ, Spassieva SD, Voit EO, Obeid LM. Yeast sphingolipid metabolism: clues and connections. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 82: 45-61. PMID 15052327 DOI: 10.1139/O03-086 |
0.747 |
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| 2004 |
Marchesini N, Osta W, Bielawski J, Luberto C, Obeid LM, Hannun YA. Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. The Journal of Biological Chemistry. 279: 25101-11. PMID 15051724 DOI: 10.1074/Jbc.M313662200 |
0.458 |
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| 2004 |
Taha TA, Osta W, Kozhaya L, Bielawski J, Johnson KR, Gillanders WE, Dbaibo GS, Hannun YA, Obeid LM. Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. The Journal of Biological Chemistry. 279: 20546-54. PMID 14988393 DOI: 10.1074/Jbc.M401259200 |
0.473 |
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| 2004 |
Sundararaj KP, Wood RE, Ponnusamy S, Salas AM, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Ogretmen B. Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. The Journal of Biological Chemistry. 279: 6152-62. PMID 14630908 DOI: 10.1074/Jbc.M310549200 |
0.354 |
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| 2004 |
Norris JS, Holman DH, El-Zawahry AM, Schwartz DA, Bielawska A, Obeid LM, Hannun YA, Dong J. 676. A Role for Ceramide in AdGFPFasLTET Gene Therapy|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.640 |
0.353 |
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| 2003 |
Kraveka JM, Li L, Bielawski J, Obeid LM, Ogretmen B. Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells. Archives of Biochemistry and Biophysics. 419: 110-9. PMID 14592454 DOI: 10.1016/J.Abb.2003.08.034 |
0.401 |
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| 2003 |
Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, Chalfant CE, Obeid LM, Hannun YA. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1411-21. PMID 12890694 DOI: 10.1096/Fj.02-1038Com |
0.441 |
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| 2003 |
Johnson KR, Johnson KY, Becker KP, Bielawski J, Mao C, Obeid LM. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. The Journal of Biological Chemistry. 278: 34541-7. PMID 12815058 DOI: 10.1074/Jbc.M301741200 |
0.483 |
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| 2003 |
Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM. Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. The Journal of Biological Chemistry. 278: 31184-91. PMID 12783875 DOI: 10.1074/Jbc.M303875200 |
0.428 |
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| 2003 |
Sato M, Markiewicz M, Yamanaka M, Bielawska A, Mao C, Obeid LM, Hannun YA, Trojanowska M. Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. The Journal of Biological Chemistry. 278: 9276-82. PMID 12515830 DOI: 10.1074/Jbc.M211529200 |
0.343 |
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| 2002 |
Argraves KM, Obeid LM, Hannun YA. Sphingolipids in vascular biology. Advances in Experimental Medicine and Biology. 507: 439-44. PMID 12664623 DOI: 10.1007/978-1-4615-0193-0_68 |
0.43 |
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| 2002 |
Obeid LM, Okamoto Y, Mao C. Yeast sphingolipids: metabolism and biology. Biochimica Et Biophysica Acta. 1585: 163-171. PMID 12531550 DOI: 10.1016/S1388-1981(02)00337-2 |
0.444 |
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| 2002 |
Okamoto Y, Obeid LM, Hannun YA. Bcl-xL interrupts oxidative activation of neutral sphingomyelinase. Febs Letters. 530: 104-8. PMID 12387875 DOI: 10.1016/S0014-5793(02)03435-X |
0.406 |
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| 2002 |
Luberto C, Hassler DF, Signorelli P, Okamoto Y, Sawai H, Boros E, Hazen-Martin DJ, Obeid LM, Hannun YA, Smith GK. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. The Journal of Biological Chemistry. 277: 41128-39. PMID 12154098 DOI: 10.1074/Jbc.M206747200 |
0.404 |
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| 2002 |
Johnson KR, Becker KP, Facchinetti MM, Hannun YA, Obeid LM. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). The Journal of Biological Chemistry. 277: 35257-62. PMID 12124383 DOI: 10.1074/Jbc.M203033200 |
0.483 |
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| 2002 |
Birbes H, El Bawab S, Obeid LM, Hannun YA. Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Advances in Enzyme Regulation. 42: 113-29. PMID 12123710 DOI: 10.1016/S0065-2571(01)00026-7 |
0.36 |
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| 2002 |
el Bawab S, Mao C, Obeid LM, Hannun YA. Ceramidases in the regulation of ceramide levels and function. Sub-Cellular Biochemistry. 36: 187-205. PMID 12037981 DOI: 10.1007/0-306-47931-1_10 |
0.349 |
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| 2002 |
Hannun YA, Obeid LM. The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. The Journal of Biological Chemistry. 277: 25847-50. PMID 12011103 DOI: 10.1074/Jbc.R200008200 |
0.34 |
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| 2002 |
Ogretmen B, Pettus BJ, Rossi MJ, Wood R, Usta J, Szulc Z, Bielawska A, Obeid LM, Hannun YA. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. The Journal of Biological Chemistry. 277: 12960-9. PMID 11815611 DOI: 10.1074/Jbc.M110699200 |
0.37 |
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| 2002 |
Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, Hannun YA. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. The Journal of Biological Chemistry. 277: 12587-95. PMID 11801602 DOI: 10.1074/Jbc.M112010200 |
0.373 |
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| 2002 |
Birbes H, El Bawab S, Hannun YA, Obeid LM. Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 2669-79. PMID 11726543 DOI: 10.1096/fj.01-0539com |
0.307 |
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| 2001 |
Hayter HL, Pettus BJ, Ito F, Obeid LM, Hannun YA. TNFalpha-induced glutathione depletion lies downstream of cPLA(2) in L929 cells. Febs Letters. 507: 151-6. PMID 11684089 DOI: 10.1016/S0014-5793(01)02967-2 |
0.43 |
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| 2001 |
Boujaoude LC, Bradshaw-Wilder C, Mao C, Cohn J, Ogretmen B, Hannun YA, Obeid LM. Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: Modulation of cellular activity of sphingosine 1-phosphate Journal of Biological Chemistry. 276: 35258-35264. PMID 11443135 DOI: 10.1074/Jbc.M105442200 |
0.435 |
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| 2001 |
Ogretmen B, Kraveka JM, Schady D, Usta J, Hannun YA, Obeid LM. Molecular Mechanisms of Ceramide-mediated Telomerase Inhibition in the A549 Human Lung Adenocarcinoma Cell Line Journal of Biological Chemistry. 276: 32506-32514. PMID 11441001 DOI: 10.1074/Jbc.M101350200 |
0.372 |
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| 2001 |
Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM. Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. The Journal of Biological Chemistry. 276: 26577-88. PMID 11356846 DOI: 10.1074/Jbc.M102818200 |
0.389 |
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| 2001 |
Ogretmen B, Schady D, Usta J, Wood R, Kraveka JM, Luberto C, Birbes H, Hannun YA, Obeid LM. Role of Ceramide in Mediating the Inhibition of Telomerase Activity in A549 Human Lung Adenocarcinoma Cells Journal of Biological Chemistry. 276: 24901-24910. PMID 11335714 DOI: 10.1074/Jbc.M100314200 |
0.408 |
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| 2001 |
Lee JY, Bielawska AE, Obeid LM. Regulation of cyclin-dependent kinase 2 activity by ceramide. Experimental Cell Research. 261: 303-11. PMID 11112337 DOI: 10.1006/Excr.2000.5028 |
0.467 |
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| 2001 |
Smith ER, Merrill AH, Obeid LM, Hannun YA. Effects of sphingosine and other sphingolipids on protein kinase C. Methods in Enzymology. 312: 361-73. PMID 11070884 DOI: 10.1016/S0076-6879(00)12921-0 |
0.343 |
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| 2000 |
Mao C, Xu R, Bielawska A, Szulc ZM, Obeid LM. Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. The Journal of Biological Chemistry. 275: 31369-78. PMID 10900202 DOI: 10.1074/Jbc.M003683200 |
0.366 |
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| 2000 |
Lee JY, Hannun YA, Obeid LM. Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. The Journal of Biological Chemistry. 275: 29290-8. PMID 10887171 DOI: 10.1074/Jbc.M000170200 |
0.323 |
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| 2000 |
Chung N, Jenkins G, Hannun YA, Heitman J, Obeid LM. Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. The Journal of Biological Chemistry. 275: 17229-32. PMID 10764732 DOI: 10.1074/Jbc.C000229200 |
0.328 |
|
| 2000 |
Mao C, Xu R, Bielawska A, Obeid LM. Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. The Journal of Biological Chemistry. 275: 6876-84. PMID 10702247 DOI: 10.1074/Jbc.275.10.6876 |
0.368 |
|
| 1999 |
Chung N, Obeid LM. Use of yeast as a model system for studies of sphingolipid metabolism and signaling Methods in Enzymology. 311: 319-331. PMID 10563337 DOI: 10.1016/S0076-6879(00)11093-6 |
0.334 |
|
| 1999 |
Mao C, Obeid LM. Yeast sphingosine-1-phosphate phosphatases: Assay, expression, deletion, purification, and cellular localization by GFP tagging Methods in Enzymology. 311: 223-233. PMID 10563329 DOI: 10.1016/S0076-6879(00)11085-7 |
0.405 |
|
| 1999 |
Venable ME, Obeid LM. Phospholipase D in cellular senescence. Biochimica Et Biophysica Acta. 1439: 291-8. PMID 10425402 DOI: 10.1016/S1388-1981(99)00101-8 |
0.48 |
|
| 1999 |
Zhang J, Reedy MC, Hannun YA, Obeid LM. Inhibition of caspases inhibits the release of apoptotic bodies: Bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosis. The Journal of Cell Biology. 145: 99-108. PMID 10189371 DOI: 10.1083/Jcb.145.1.99 |
0.35 |
|
| 1999 |
Mao C, Saba JD, Obeid LM. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochemical Journal. 342: 667-675. DOI: 10.1042/Bj3420667 |
0.434 |
|
| 1998 |
Zhang J, Driscoll TA, Hannun YA, Obeid LM. Regulation of membrane release in apoptosis. The Biochemical Journal. 479-85. PMID 9716508 DOI: 10.1042/Bj3340479 |
0.363 |
|
| 1998 |
Lee JY, Leonhardt LG, Obeid LM. Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M. The Biochemical Journal. 457-61. PMID 9716505 DOI: 10.1042/Bj3340457 |
0.384 |
|
| 1998 |
Liu B, Andrieu-Abadie N, Levade T, Zhang P, Obeid LM, Hannun YA. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. The Journal of Biological Chemistry. 273: 11313-20. PMID 9556624 DOI: 10.1074/Jbc.273.18.11313 |
0.446 |
|
| 1997 |
Perry DK, Smyth MJ, Wang HG, Reed JC, Duriez P, Poirier GG, Obeid LM, Hannun YA. Bcl-2 acts upstream of the PARP protease and prevents its activation. Cell Death and Differentiation. 4: 29-33. PMID 16465207 DOI: 10.1038/Sj.Cdd.4400200 |
0.413 |
|
| 1997 |
Liu B, Obeid LM, Hannun YA. Sphingomyelinases in cell regulation. Seminars in Cell & Developmental Biology. 8: 311-322. PMID 10024495 DOI: 10.1006/Scdb.1997.0153 |
0.475 |
|
| 1997 |
Zhang P, Liu B, Kang SW, Seo MS, Rhee SG, Obeid LM. Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2 Journal of Biological Chemistry. 272: 30615-30618. PMID 9388194 DOI: 10.1074/Jbc.272.49.30615 |
0.399 |
|
| 1997 |
Mao C, Wadleigh M, Jenkins GM, Hannun YA, Obeid LM. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. The Journal of Biological Chemistry. 272: 28690-4. PMID 9353337 DOI: 10.1074/Jbc.272.45.28690 |
0.341 |
|
| 1997 |
Hannun YA, Obeid LM. Mechanisms of ceramide-mediated apoptosis. Advances in Experimental Medicine and Biology. 407: 145-9. PMID 9321945 DOI: 10.1007/978-1-4899-1813-0_22 |
0.425 |
|
| 1997 |
Lee TG, Park JB, Lee SD, Hong S, Kim JH, Kim Y, Yi KS, Bae S, Hannun YA, Obeid LM, Suh PG, Ryu SH. Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. Biochimica Et Biophysica Acta. 1347: 199-204. PMID 9295164 DOI: 10.1016/S0005-2760(97)00083-0 |
0.384 |
|
| 1997 |
Gamard CJ, Dbaibo GS, Liu B, Obeid LM, Hannun YA. Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB. The Journal of Biological Chemistry. 272: 16474-81. PMID 9195956 DOI: 10.1074/Jbc.272.26.16474 |
0.4 |
|
| 1997 |
Zhang P, Liu B, Jenkins GM, Hannun YA, Obeid LM. Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. The Journal of Biological Chemistry. 272: 9609-12. PMID 9092485 DOI: 10.1074/Jbc.272.15.9609 |
0.431 |
|
| 1997 |
Obeid LM, Venable ME. GERIATRIC BIOSCIENCE: Signal Transduction in Cellular Senescence Journal of the American Geriatrics Society. 45: 361-366. PMID 9063284 DOI: 10.1111/J.1532-5415.1997.Tb00954.X |
0.308 |
|
| 1997 |
Dbaibo GS, Perry DK, Gamard CJ, Platt R, Poirier GG, Obeid LM, Hannun YA. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. The Journal of Experimental Medicine. 185: 481-90. PMID 9053448 DOI: 10.1084/Jem.185.3.481 |
0.398 |
|
| 1996 |
Perry DK, Obeid LM, Hannun YA. Ceramide and the regulation of apoptosis and the stress response. Trends in Cardiovascular Medicine. 6: 158-62. PMID 21232290 DOI: 10.1016/1050-1738(96)00044-8 |
0.418 |
|
| 1996 |
Lee JY, Hannun YA, Obeid LM. Ceramide inactivates cellular protein kinase Calpha. The Journal of Biological Chemistry. 271: 13169-74. PMID 8662781 DOI: 10.1074/Jbc.271.22.13169 |
0.444 |
|
| 1996 |
Saba JD, Obeid LM, Hannun YA. Ceramide: an intracellular mediator of apoptosis and growth suppression. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 351: 233-40; discussion 2. PMID 8650271 DOI: 10.1098/Rstb.1996.0021 |
0.473 |
|
| 1996 |
Smyth MJ, Perry DK, Zhang J, Poirier GG, Hannun YA, Obeid LM. prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. The Biochemical Journal. 316: 25-8. PMID 8645213 DOI: 10.1042/Bj3160025 |
0.379 |
|
| 1996 |
Zhang J, Alter N, Reed JC, Borner C, Obeid LM, Hannun YA. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proceedings of the National Academy of Sciences of the United States of America. 93: 5325-8. PMID 8643573 DOI: 10.1073/Pnas.93.11.5325 |
0.438 |
|
| 1996 |
Venable ME, Lee JY, Smyth MJ, Bielawska A, Obeid LM. Role of ceramide in cellular senescence. The Journal of Biological Chemistry. 270: 30701-8. PMID 8530509 DOI: 10.1074/Jbc.270.51.30701 |
0.467 |
|
| 1996 |
Perry DK, Obeid LM, Hannun YA. Ceramide and the regulation of apoptosis and the stress response Trends in Cardiovascular Medicine. 6: 158-162. DOI: 10.1016/1050-1738(96)00044-8 |
0.305 |
|
| 1995 |
Dbaibo GS, Pushkareva MY, Jayadev S, Schwarz JK, Horowitz JM, Obeid LM, Hannun YA. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest Proceedings of the National Academy of Sciences of the United States of America. 92: 1347-1351. PMID 7877980 DOI: 10.1073/Pnas.92.5.1347 |
0.435 |
|
| 1995 |
Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Obeid LM, Hannun YA. Role for ceramide in cell cycle arrest. The Journal of Biological Chemistry. 270: 2047-52. PMID 7836432 DOI: 10.1074/Jbc.270.5.2047 |
0.443 |
|
| 1995 |
Blobe GC, Obeid LM, Hannun YA. Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Reviews. 13: 411-31. PMID 7712599 DOI: 10.1007/Bf00666107 |
0.463 |
|
| 1995 |
Hannun YA, Obeid LM. Ceramide: an intracellular signal for apoptosis. Trends in Biochemical Sciences. 20: 73-7. PMID 7701566 DOI: 10.1016/S0968-0004(00)88961-6 |
0.472 |
|
| 1995 |
Obeid LM, Hannun YA. Ceramide: a stress signal and mediator of growth suppression and apoptosis. Journal of Cellular Biochemistry. 58: 191-8. PMID 7673327 DOI: 10.1002/Jcb.240580208 |
0.452 |
|
| 1995 |
Pushkareva M, Obeid LM, Hannun YA. Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunology Today. 16: 294-7. PMID 7662099 DOI: 10.1016/0167-5699(95)80184-7 |
0.456 |
|
| 1995 |
Dbaibo GS, Wolff RA, Obeid LM, Hannun YA. Activation of a retinoblastoma-protein-dependent pathway by sphingosine. The Biochemical Journal. 453-9. PMID 7654183 DOI: 10.1042/Bj3100453 |
0.44 |
|
| 1993 |
Obeid LM, Linardic CM, Karolak LA, Hannun YA. Programmed cell death induced by ceramide. Science (New York, N.Y.). 259: 1769-71. PMID 8456305 DOI: 10.1126/Science.8456305 |
0.424 |
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