Michael J. Holtzman - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
Cell Biology, Microbiology Biology, Molecular Biology, Public Health

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Year Citation  Score
2024 Holtzman MJ, Zhang Y, Wu K, Romero AG. Mitogen-activated protein kinase-guided drug discovery for post-viral and related types of lung disease. European Respiratory Review : An Official Journal of the European Respiratory Society. 33. PMID 38417971 DOI: 10.1183/16000617.0220-2023  0.327
2023 Wu K, Zhang Y, Austin SR, Declue HY, Byers DE, Crouch EC, Holtzman MJ. Lung remodeling regions in long-term Covid-19 feature basal epithelial cell reprogramming. The American Journal of Pathology. PMID 36868468 DOI: 10.1016/j.ajpath.2023.02.005  0.323
2022 Wu K, Zhang Y, Austin SR, Declue HY, Byers DE, Crouch EC, Holtzman MJ. Lung remodeling regions in long-term Covid-19 feature basal epithelial cell reprogramming. Medrxiv : the Preprint Server For Health Sciences. PMID 36172126 DOI: 10.1101/2022.09.17.22280043  0.308
2022 Hazan G, Eubanks A, Gierasch C, Atkinson J, Fox C, Hernandez-Leyva A, Rosen AL, Kau AL, Agapov E, Alexander-Brett J, Steinberg D, Kelley D, White M, Byers D, Wu K, ... ... Holtzman MJ, et al. Age-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses. Journal of Immunology (Baltimore, Md. : 1950). PMID 35173037 DOI: 10.4049/jimmunol.2101094  0.35
2021 Wu K, Kamimoto K, Zhang Y, Yang K, Keeler SP, Gerovac BJ, Agapov EV, Austin SP, Yantis J, Gissy KA, Byers DE, Alexander-Brett J, Hoffmann CM, Wallace M, Hughes ME, ... ... Holtzman MJ, et al. Basal-epithelial stem cells cross an alarmin checkpoint for post-viral lung disease. The Journal of Clinical Investigation. PMID 34343135 DOI: 10.1172/JCI149336  0.334
2021 Wang X, Wu K, Keeler SP, Mao D, Agapov EV, Zhang Y, Holtzman MJ. TLR3-Activated Monocyte-Derived Dendritic Cells Trigger Progression from Acute Viral Infection to Chronic Disease in the Lung. Journal of Immunology (Baltimore, Md. : 1950). PMID 33514511 DOI: 10.4049/jimmunol.2000965  0.427
2021 Katz-Kiriakos E, Steinberg DF, Kluender CE, Osorio OA, Newsom-Stewart C, Baronia A, Byers DE, Holtzman MJ, Katafiasz D, Bailey KL, Brody SL, Miller MJ, Alexander-Brett J. Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease. Jci Insight. PMID 33507882 DOI: 10.1172/jci.insight.136166  0.302
2020 Chen R, Wang L, Koch T, Curtis V, Yin-DeClue H, Handley SA, Shan L, Holtzman MJ, Castro M, Wang L. Gender effects in the association between airway microbiome and asthma. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. PMID 32931909 DOI: 10.1016/J.Anai.2020.09.007  0.339
2020 Hassan AO, Kafai NM, Dmitriev IP, Fox JM, Smith BK, Harvey IB, Chen RE, Winkler ES, Wessel AW, Case JB, Kashentseva E, McCune BT, Bailey AL, Zhao H, VanBlargan LA, ... ... Holtzman MJ, et al. A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2. Cell. PMID 32931734 DOI: 10.1016/J.Cell.2020.08.026  0.394
2020 Winkler ES, Bailey AL, Kafai NM, Nair S, McCune BT, Yu J, Fox JM, Chen RE, Earnest JT, Keeler SP, Ritter JH, Kang LI, Dort S, Robichaud A, Head R, ... Holtzman MJ, et al. Publisher Correction: SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function. Nature Immunology. PMID 32879513 DOI: 10.1038/S41590-020-0794-2  0.36
2020 Winkler ES, Bailey AL, Kafai NM, Nair S, McCune BT, Yu J, Fox JM, Chen RE, Earnest JT, Keeler SP, Ritter JH, Kang LI, Dort S, Robichaud A, Head R, ... Holtzman MJ, et al. SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function. Nature Immunology. PMID 32839612 DOI: 10.1038/S41590-020-0778-2  0.44
2020 Case JB, Rothlauf PW, Chen RE, Kafai NM, Fox JM, Smith BK, Shrihari S, McCune BT, Harvey IB, Keeler SP, Bloyet LM, Zhao H, Ma M, Adams LJ, Winkler ES, ... Holtzman MJ, et al. Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice. Cell Host & Microbe. PMID 32798445 DOI: 10.1016/J.Chom.2020.07.018  0.392
2020 Winkler ES, Bailey AL, Kafai NM, Nair S, McCune BT, Yu J, Fox JM, Chen RE, Earnest JT, Keeler SP, Ritter JH, Kang LI, Dort S, Robichaud A, Head R, ... Holtzman MJ, et al. SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function. Biorxiv : the Preprint Server For Biology. PMID 32676600 DOI: 10.1101/2020.07.09.196188  0.373
2020 Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schäfer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, ... ... Holtzman MJ, et al. Potently neutralizing and protective human antibodies against SARS-CoV-2. Nature. PMID 32668443 DOI: 10.1038/S41586-020-2548-6  0.331
2020 Wu K, Wang X, Keeler SP, Gerovac BJ, Agapov EV, Byers DE, Gilfillan S, Colonna M, Zhang Y, Holtzman MJ. Group 2 Innate Lymphoid Cells Must Partner with the Myeloid-Macrophage Lineage for Long-Term Postviral Lung Disease. Journal of Immunology (Baltimore, Md. : 1950). PMID 32641386 DOI: 10.4049/Jimmunol.2000181  0.515
2020 Hassan AO, Case JB, Winkler ES, Thackray LB, Kafai NM, Bailey AL, McCune BT, Fox JM, Chen RE, Alsoussi WB, Turner JS, Schmitz AJ, Lei T, Shrihari S, Keeler SP, ... ... Holtzman MJ, et al. A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies. Cell. PMID 32553273 DOI: 10.1016/J.Cell.2020.06.011  0.385
2019 Sodhi CP, Nguyen J, Yamaguchi Y, Werts AD, Lu P, Ladd MR, Fulton WB, Kovler ML, Wang S, Prindle T, Zhang Y, Lazartigues ED, Holtzman MJ, Alcorn JF, Hackam DJ, et al. A Dynamic Variation of Pulmonary ACE2 Is Required To Modulate Neutrophilic Inflammation in Response to Lung Infection in Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 31645418 DOI: 10.4049/Jimmunol.1900579  0.425
2019 Zhang Y, Mao D, Keeler SP, Wang X, Wu K, Gerovac BJ, Shornick LL, Agapov EV, Holtzman MJ. Respiratory Enterovirus (Like Parainfluenza Virus) Can Cause Chronic Lung Disease If Protection by Airway Epithelial STAT1 Is Lost. Journal of Immunology (Baltimore, Md. : 1950). PMID 30804041 DOI: 10.4049/Jimmunol.1801491  0.485
2018 Keeler SP, Gerovac BJ, Wu K, Wang X, Chartock JR, Byers DE, Romero AG, Holtzman MJ. Epithelial-Immune Cell Interactions for Drug Discovery in Chronic Obstructive Pulmonary Disease. Annals of the American Thoracic Society. 15: S260-S265. PMID 30759005 DOI: 10.1513/Annalsats.201808-531Mg  0.481
2018 Keeler SP, Agapov EV, Hinojosa ME, Letvin AN, Wu K, Holtzman MJ. Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants. Journal of Immunology (Baltimore, Md. : 1950). PMID 30209189 DOI: 10.4049/Jimmunol.1800671  0.743
2017 Siller SS, Sharma H, Li S, Yang J, Zhang Y, Holtzman MJ, Winuthayanon W, Colognato H, Holdener BC, Li FQ, Takemaru KI. Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation. Plos Genetics. 13: e1007128. PMID 29244804 DOI: 10.1371/Journal.Pgen.1007128  0.319
2017 Byers DE, Wu K, Dang-Vu G, Jin X, Agapov E, Zhang X, Battaile JT, Schechtman K, Yusen R, Pierce RA, Holtzman MJ. Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) expression tracks with M2-like macrophage activity and disease severity in COPD. Chest. PMID 29017955 DOI: 10.1016/J.Chest.2017.09.044  0.407
2017 Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science (New York, N.Y.). 357: 498-502. PMID 28774928 DOI: 10.1126/Science.Aam5336  0.401
2017 Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, et al. Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses. Nature Microbiology. 2: 17101. PMID 28665409 DOI: 10.1038/Nmicrobiol.2017.101  0.417
2017 Woodruff PG, van den Berge M, Boucher RC, Brightling C, Burchard EG, Christenson SA, Han MK, Holtzman MJ, Kraft M, Lynch DA, Martinez FD, Reddel HK, Sin DD, Washko GR, Wenzel SE, et al. ATS-NHLBI Asthma COPD Overlap (ACO) Workshop Report. American Journal of Respiratory and Critical Care Medicine. PMID 28636425 DOI: 10.1164/Rccm.201705-0973Ws  0.377
2017 Ehlers A, Xie W, Agapov E, Brown S, Steinberg D, Tidwell R, Sajol G, Schutz R, Weaver R, Yu H, Castro M, Bacharier LB, Wang X, Holtzman MJ, Haspel JA. BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes. Mucosal Immunology. PMID 28401936 DOI: 10.1038/Mi.2017.24  0.446
2017 Liu Y, Gunsten SP, Sultan DH, Luehmann HP, Zhao Y, Blackwell TS, Bollermann-Nowlis Z, Pan JH, Byers DE, Atkinson JJ, Kreisel D, Holtzman MJ, Gropler RJ, Combadiere C, Brody SL. PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation. Radiology. 161409. PMID 28045644 DOI: 10.1148/Radiol.2016161409  0.338
2016 Olias P, Etheridge RD, Zhang Y, Holtzman MJ, Sibley LD. Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression. Cell Host & Microbe. 20: 72-82. PMID 27414498 DOI: 10.1016/J.Chom.2016.06.006  0.343
2016 Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, ... ... Holtzman MJ, et al. Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell Host & Microbe. 19: 102-113. PMID 26764600 DOI: 10.1016/J.Chom.2015.12.011  0.427
2015 Chen J, Zhao J, Chen L, Dong N, Ying Z, Cai Z, Ji D, Zhang Y, Dong L, Li Y, Jiang L, Holtzman MJ, Chen C. STAT1 modification improves therapeutic effects of interferons on lung cancer cells. Journal of Translational Medicine. 13: 293. PMID 26351076 DOI: 10.1186/S12967-015-0656-0  0.351
2015 Dickinson JD, Alevy Y, Malvin NP, Patel KK, Gunsten SP, Holtzman MJ, Stappenbeck TS, Brody SL. IL13 activates autophagy to regulate secretion in airway epithelial cells. Autophagy. 0. PMID 26062017 DOI: 10.1080/15548627.2015.1056967  0.46
2015 Wu K, Byers DE, Jin X, Agapov E, Alexander-Brett J, Patel AC, Cella M, Gilfilan S, Colonna M, Kober DL, Brett TJ, Holtzman MJ. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. The Journal of Experimental Medicine. 212: 681-97. PMID 25897174 DOI: 10.1084/Jem.20141732  0.407
2015 Kim HJ, Kim CH, Kim MJ, Ryu JH, Seong SY, Kim S, Lim SJ, Holtzman MJ, Yoon JH. Duox2-derived Reactive Oxygen Species Induce Pattern Recognition Receptors' Expression Against Influenza A Virus in Nasal Mucosa. American Journal of Respiratory Cell and Molecular Biology. PMID 25751630 DOI: 10.1165/Rcmb.2014-0334Oc  0.41
2015 Gowdy KM, Martinu T, Nugent JL, Manzo ND, Zhang HL, Kelly FL, Holtzman MJ, Palmer SM. Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection. Transplant Immunology. 32: 51-60. PMID 25446809 DOI: 10.1016/J.Trim.2014.10.005  0.367
2015 Morales DJ, Monte K, Sun L, Struckhoff JJ, Agapov E, Holtzman MJ, Stappenbeck TS, Lenschow DJ. Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice. Journal of Virology. 89: 337-49. PMID 25320315 DOI: 10.1128/Jvi.02110-14  0.385
2015 Alexander-Brett J, Holtzman MJ. Virus Infection of Airway Epithelial Cells Mucosal Immunology: Fourth Edition. 1: 1013-1021. DOI: 10.1016/B978-0-12-415847-4.00053-7  0.442
2014 Holtzman MJ, Byers DE, Brett JA, Patel AC, Agapov E, Jin X, Wu K. Linking acute infection to chronic lung disease. The role of IL-33-expressing epithelial progenitor cells. Annals of the American Thoracic Society. 11: S287-91. PMID 25525734 DOI: 10.1513/Annalsats.201402-056Aw  0.464
2014 Holtzman MJ, Byers DE, Alexander-Brett J, Wang X. The role of airway epithelial cells and innate immune cells in chronic respiratory disease. Nature Reviews. Immunology. 14: 686-98. PMID 25234144 DOI: 10.1038/Nri3739  0.375
2014 Patel DA, You Y, Huang G, Byers DE, Kim HJ, Agapov E, Moore ML, Peebles RS, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ. Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. The Journal of Allergy and Clinical Immunology. 134: 1402-1412.e7. PMID 25216987 DOI: 10.1016/J.Jaci.2014.07.013  0.454
2014 Pan JH, Adair-Kirk TL, Patel AC, Huang T, Yozamp NS, Xu J, Reddy EP, Byers DE, Pierce RA, Holtzman MJ, Brody SL. Myb permits multilineage airway epithelial cell differentiation. Stem Cells (Dayton, Ohio). 32: 3245-56. PMID 25103188 DOI: 10.1002/Stem.1814  0.379
2014 Philippot Q, Deslée G, Adair-Kirk TL, Woods JC, Byers D, Conradi S, Dury S, Perotin JM, Lebargy F, Cassan C, Le Naour R, Holtzman MJ, Pierce RA. Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease. Plos One. 9: e96285. PMID 24789352 DOI: 10.1371/Journal.Pone.0096285  0.304
2014 Kober DL, Wanhainen KM, Johnson BM, Randolph DT, Holtzman MJ, Brett TJ. Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases. Protein Expression and Purification. 96: 32-8. PMID 24508568 DOI: 10.1016/J.Pep.2014.01.015  0.326
2014 Gu X, Karp PH, Brody SL, Pierce RA, Welsh MJ, Holtzman MJ, Ben-Shahar Y. Chemosensory functions for pulmonary neuroendocrine cells. American Journal of Respiratory Cell and Molecular Biology. 50: 637-46. PMID 24134460 DOI: 10.1165/Rcmb.2013-0199Oc  0.388
2013 Byers DE, Alexander-Brett J, Patel AC, Agapov E, Dang-Vu G, Jin X, Wu K, You Y, Alevy Y, Girard JP, Stappenbeck TS, Patterson GA, Pierce RA, Brody SL, Holtzman MJ. Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. The Journal of Clinical Investigation. 123: 3967-82. PMID 23945235 DOI: 10.1172/Jci65570  0.337
2013 Kim HJ, Kim CH, Ryu JH, Kim MJ, Park CY, Lee JM, Holtzman MJ, Yoon JH. Reactive oxygen species induce antiviral innate immune response through IFN-λ regulation in human nasal epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 49: 855-65. PMID 23786562 DOI: 10.1165/Rcmb.2013-0003Oc  0.427
2012 Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ, Holtzman MJ. IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. The Journal of Clinical Investigation. 122: 4555-68. PMID 23187130 DOI: 10.1172/Jci64896  0.306
2012 Yurtsever Z, Sala-Rabanal M, Randolph DT, Scheaffer SM, Roswit WT, Alevy YG, Patel AC, Heier RF, Romero AG, Nichols CG, Holtzman MJ, Brett TJ. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. The Journal of Biological Chemistry. 287: 42138-49. PMID 23112050 DOI: 10.1074/Jbc.M112.410282  0.314
2012 Page C, Goicochea L, Matthews K, Zhang Y, Klover P, Holtzman MJ, Hennighausen L, Frieman M. Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection. Journal of Virology. 86: 13334-49. PMID 23015710 DOI: 10.1128/Jvi.01689-12  0.458
2012 Holtzman MJ. Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens. The Journal of Clinical Investigation. 122: 2741-8. PMID 22850884 DOI: 10.1172/Jci60325  0.489
2012 Patel DA, Patel AC, Nolan WC, Zhang Y, Holtzman MJ. High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery. Plos One. 7: e36594. PMID 22574190 DOI: 10.1371/Journal.Pone.0036594  0.35
2012 Sumino K, Tucker J, Shahab M, Jaffee KF, Visness CM, Gern JE, Bloomberg GR, Holtzman MJ. Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life. The Journal of Allergy and Clinical Immunology. 129: 1267-1273.e1. PMID 22460071 DOI: 10.1016/J.Jaci.2012.02.033  0.412
2012 Wang W, Nguyen NM, Agapov E, Holtzman MJ, Woods JC. Monitoring in vivo changes in lung microstructure with ³He MRI in Sendai virus-infected mice. Journal of Applied Physiology (Bethesda, Md. : 1985). 112: 1593-9. PMID 22383505 DOI: 10.1152/Japplphysiol.01165.2011  0.403
2011 Byers DE, Holtzman MJ. Alternatively activated macrophages and airway disease. Chest. 140: 768-74. PMID 21896520 DOI: 10.1378/Chest.10-2132  0.494
2011 Holtzman MJ, Patel DA, Zhang Y, Patel AC. Host epithelial-viral interactions as cause and cure for asthma. Current Opinion in Immunology. 23: 487-94. PMID 21703838 DOI: 10.1016/J.Coi.2011.05.010  0.5
2011 Holtzman M, Patel D, Kim HJ, Kim H, You Y, Zhang Y. Hypersusceptibility to respiratory viruses as a shared mechanism for asthma, chronic obstructive pulmonary disease, and cystic fibrosis. American Journal of Respiratory Cell and Molecular Biology. 44: 739-42. PMID 21653905 DOI: 10.1165/Rcmb.2011-0120Ed  0.392
2011 Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson AM, Holtzman MJ, Whitsett JA, Hershey GK. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. American Journal of Physiology. Lung Cellular and Molecular Physiology. 300: L414-21. PMID 21224214 DOI: 10.1152/Ajplung.00346.2010  0.374
2010 Zhang Y, Hinojosa ME, Yoo N, Holtzman MJ. Viral and host strategies to take advantage of the innate immune response. American Journal of Respiratory Cell and Molecular Biology. 43: 507-10. PMID 20971885 DOI: 10.1165/Rcmb.2009-0213Ed  0.721
2010 Cheung DS, Ehlenbach SJ, Kitchens RT, Riley DA, Thomas LL, Holtzman MJ, Grayson MH. Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. Journal of Immunology (Baltimore, Md. : 1950). 185: 4983-7. PMID 20876348 DOI: 10.4049/Jimmunol.1002456  0.459
2010 Sumino KC, Walter MJ, Mikols CL, Thompson SA, Gaudreault-Keener M, Arens MQ, Agapov E, Hormozdi D, Gaynor AM, Holtzman MJ, Storch GA. Detection of respiratory viruses and the associated chemokine responses in serious acute respiratory illness. Thorax. 65: 639-44. PMID 20627924 DOI: 10.1136/Thx.2009.132480  0.342
2010 Byers DE, Holtzman MJ. Alternatively activated macrophages as cause or effect in airway disease. American Journal of Respiratory Cell and Molecular Biology. 43: 1-4. PMID 20587775 DOI: 10.1165/Rcmb.2009-0407Ed  0.374
2010 Benoit LA, Holtzman MJ. New immune pathways from chronic post-viral lung disease. Annals of the New York Academy of Sciences. 1183: 195-210. PMID 20146716 DOI: 10.1111/J.1749-6632.2009.05136.X  0.482
2010 Gitlin L, Benoit L, Song C, Cella M, Gilfillan S, Holtzman MJ, Colonna M. Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. Plos Pathogens. 6: e1000734. PMID 20107606 DOI: 10.1371/Journal.Ppat.1000734  0.442
2010 Wu X, Micka WS, Mao D, Kolar G, Zhang Y, Holtzman MJ, Atkinson JP. Complement deficiency leads to a prominent lymphoid nodule development in a Sendai virus-induced mouse model of asthma Molecular Immunology. 47: 2273-2273. DOI: 10.1016/J.Molimm.2010.05.223  0.38
2009 Tachdjian R, Mathias C, Al Khatib S, Bryce PJ, Kim HS, Blaeser F, O'Connor BD, Rzymkiewicz D, Chen A, Holtzman MJ, Hershey GK, Garn H, Harb H, Renz H, Oettgen HC, et al. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. The Journal of Experimental Medicine. 206: 2191-204. PMID 19770271 DOI: 10.1084/Jem.20091480  0.359
2009 Agapov E, Battaile JT, Tidwell R, Hachem R, Patterson GA, Pierce RA, Atkinson JJ, Holtzman MJ. Macrophage chitinase 1 stratifies chronic obstructive lung disease. American Journal of Respiratory Cell and Molecular Biology. 41: 379-84. PMID 19491341 DOI: 10.1165/2009-0122Rc  0.381
2009 Holtzman MJ, Byers DE, Benoit LA, Battaile JT, You Y, Agapov E, Park C, Grayson MH, Kim EY, Patel AC. Immune pathways for translating viral infection into chronic airway disease. Advances in Immunology. 102: 245-76. PMID 19477323 DOI: 10.1016/S0065-2776(09)01205-X  0.679
2009 Deslee G, Woods JC, Moore CM, Liu L, Conradi SH, Milne M, Gierada DS, Pierce J, Patterson A, Lewit RA, Battaile JT, Holtzman MJ, Hogg JC, Pierce RA. Elastin expression in very severe human COPD. The European Respiratory Journal. 34: 324-31. PMID 19357152 DOI: 10.1183/09031936.00123008  0.356
2009 Patel AC, Brett TJ, Holtzman MJ. The role of CLCA proteins in inflammatory airway disease. Annual Review of Physiology. 71: 425-49. PMID 18954282 DOI: 10.1146/Annurev.Physiol.010908.163253  0.4
2008 Kim EY, Battaile JT, Patel AC, You Y, Agapov E, Grayson MH, Benoit LA, Byers DE, Alevy Y, Tucker J, Swanson S, Tidwell R, Tyner JW, Morton JD, Castro M, ... ... Holtzman MJ, et al. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nature Medicine. 14: 633-40. PMID 18488036 DOI: 10.1038/Nm1770  0.709
2008 Fujisawa T, Ide K, Holtzman MJ, Suda T, Suzuki K, Kuroishi S, Chida K, Nakamura H. Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cells. Respirology (Carlton, Vic.). 13: 191-202. PMID 18339016 DOI: 10.1111/J.1440-1843.2008.01237.X  0.366
2008 Akk AM, Simmons PM, Chan HW, Agapov E, Holtzman MJ, Grayson MH, Pham CT. Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection. Journal of Immunology (Baltimore, Md. : 1950). 180: 3535-42. PMID 18292580 DOI: 10.4049/Jimmunol.180.5.3535  0.482
2008 Shornick LP, Wells AG, Zhang Y, Patel AC, Huang G, Takami K, Sosa M, Shukla NA, Agapov E, Holtzman MJ. Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection. Journal of Immunology (Baltimore, Md. : 1950). 180: 3319-28. PMID 18292557 DOI: 10.4049/Jimmunol.180.5.3319  0.461
2007 Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, Alevy Y, Yan L, Agapov E, Kim EY, Holtzman MJ. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. The Journal of Experimental Medicine. 204: 2759-69. PMID 17954569 DOI: 10.1084/Jem.20070360  0.628
2007 Grayson MH, Holtzman MJ. Emerging role of dendritic cells in respiratory viral infection. Journal of Molecular Medicine (Berlin, Germany). 85: 1057-68. PMID 17891367 DOI: 10.1007/S00109-007-0212-3  0.482
2007 Grayson MH, Ramos MS, Rohlfing MM, Kitchens R, Wang HD, Gould A, Agapov E, Holtzman MJ. Controls for lung dendritic cell maturation and migration during respiratory viral infection. Journal of Immunology (Baltimore, Md. : 1950). 179: 1438-48. PMID 17641009 DOI: 10.4049/Jimmunol.179.3.1438  0.455
2007 Stout BA, Melendez K, Seagrave J, Holtzman MJ, Wilson B, Xiang J, Tesfaigzi Y. STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous cell hyperplasia by IFN-gamma. Journal of Immunology (Baltimore, Md. : 1950). 178: 8107-16. PMID 17548649 DOI: 10.4049/Jimmunol.178.12.8107  0.362
2007 Zhang Y, Huang G, Shornick LP, Roswit WT, Shipley JM, Brody SL, Holtzman MJ. A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 36: 515-9. PMID 17255554 DOI: 10.1165/Rcmb.2006-0475Rc  0.376
2006 Grayson MH, Holtzman MJ. Chemokine complexity: the case for CCL5. American Journal of Respiratory Cell and Molecular Biology. 35: 143-6. PMID 16847105 DOI: 10.1165/Rcmb.F318  0.444
2006 Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. American Journal of Respiratory Cell and Molecular Biology. 34: 523-6. PMID 16618787 DOI: 10.1165/Rcmb.F311  0.344
2006 Patel AC, Morton JD, Kim EY, Alevy Y, Swanson S, Tucker J, Huang G, Agapov E, Phillips TE, Fuentes ME, Iglesias A, Aud D, Allard JD, Dabbagh K, Peltz G, ... Holtzman MJ, et al. Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members. Physiological Genomics. 25: 502-13. PMID 16569774 DOI: 10.1152/Physiolgenomics.00321.2005  0.595
2006 Deppong C, Juehne TI, Hurchla M, Friend LD, Shah DD, Rose CM, Bricker TL, Shornick LP, Crouch EC, Murphy TL, Holtzman MJ, Murphy KM, Green JM. Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation. Journal of Immunology (Baltimore, Md. : 1950). 176: 3909-13. PMID 16547224 DOI: 10.4049/Jimmunol.176.7.3909  0.34
2006 Holtzman MJ, Battaile JT, Patel AC. Immunogenetic programs for viral induction of mucous cell metaplasia. American Journal of Respiratory Cell and Molecular Biology. 35: 29-39. PMID 16543602 DOI: 10.1165/Rcmb.2006-0092Sf  0.463
2006 Grayson MH, Holtzman MJ. Chemokine signaling regulates apoptosis as well as immune cell traffic in host defense. Cell Cycle (Georgetown, Tex.). 5: 380-3. PMID 16479157 DOI: 10.4161/Cc.5.4.2427  0.429
2006 Tyner JW, Kim EY, Ide K, Pelletier MR, Roswit WT, Morton JD, Battaile JT, Patel AC, Patterson GA, Castro M, Spoor MS, You Y, Brody SL, Holtzman MJ. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. The Journal of Clinical Investigation. 116: 309-21. PMID 16453019 DOI: 10.1172/Jci25167  0.648
2006 Agapov E, Sumino KC, Gaudreault-Keener M, Storch GA, Holtzman MJ. Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illness. The Journal of Infectious Diseases. 193: 396-403. PMID 16388487 DOI: 10.1086/499310  0.302
2005 Tyner JW, Uchida O, Kajiwara N, Kim EY, Patel AC, O'Sullivan MP, Walter MJ, Schwendener RA, Cook DN, Danoff TM, Holtzman MJ. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nature Medicine. 11: 1180-7. PMID 16208318 DOI: 10.1038/Nm1303  0.67
2005 Holtzman MJ, Tyner JW, Kim EY, Lo MS, Patel AC, Shornick LP, Agapov E, Zhang Y. Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 2: 132-40. PMID 16113481 DOI: 10.1513/pats.200502-015AW  0.79
2005 Sumino KC, Agapov E, Pierce RA, Trulock EP, Pfeifer JD, Ritter JH, Gaudreault-Keener M, Storch GA, Holtzman MJ. Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment. The Journal of Infectious Diseases. 192: 1052-60. PMID 16107959 DOI: 10.1086/432728  0.335
2005 Zhang Y, Takami K, Lo MS, Huang G, Yu Q, Roswit WT, Holtzman MJ. Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment. The Journal of Biological Chemistry. 280: 34306-15. PMID 16107341 DOI: 10.1074/Jbc.M503263200  0.642
2005 Holtzman MJ, Kim EY, Lo MS, Tyner JW, Shornick LP, Sumino KC, Zhang Y. Defining and adjusting divergent host responses to viral infection. Immunologic Research. 32: 123-41. PMID 16106064 DOI: 10.1385/Ir:32:1-3:123  0.788
2005 Lo MS, Brazas RM, Holtzman MJ. Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness. Journal of Virology. 79: 9315-9. PMID 15994826 DOI: 10.1128/Jvi.79.14.9315-9319.2005  0.656
2005 Walter MJ, Holtzman MJ. A centennial history of research on asthma pathogenesis. American Journal of Respiratory Cell and Molecular Biology. 32: 483-9. PMID 15901618 DOI: 10.1165/Rcmb.F300  0.389
2004 Holtzman MJ, Shornick LP, Grayson MH, Kim EY, Tyner JW, Patel AC, Agapov E, Zhang Y. "Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease. The Pediatric Infectious Disease Journal. 23: S235-45. PMID 15577579 DOI: 10.1097/01.Inf.0000144674.24802.C1  0.701
2004 Castro M, Bloch SR, Jenkerson MV, DeMartino S, Hamilos DL, Cochran RB, Zhang XE, Wang H, Bradley JP, Schechtman KB, Holtzman MJ. Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway. American Journal of Respiratory and Critical Care Medicine. 169: 842-9. PMID 14726420 DOI: 10.1164/Rccm.200208-960Oc  0.387
2003 Holtzman MJ. Drug development for asthma. American Journal of Respiratory Cell and Molecular Biology. 29: 163-71. PMID 12878583 DOI: 10.1165/Rcmb.F276  0.382
2003 O'Sullivan MP, Tyner JW, Holtzman MJ. Apoptosis in the airways: another balancing act in the epithelial program. American Journal of Respiratory Cell and Molecular Biology. 29: 3-7. PMID 12821445 DOI: 10.1165/Rcmb.F273  0.622
2003 Holtzman MJ, Agapov E, Kim E, Kim JI, Morton JD. Developing the epithelial, viral, and allergic paradigm for asthma: Giles F. Filley lecture. Chest. 123: 377S-84S. PMID 12628993 DOI: 10.1378/Chest.123.3_Suppl.377S  0.562
2003 Grayson M, Rohlfing M, Holtzman M. Dendritic cell homing to murine lung is not CCL5 or CCR5 dependent Journal of Allergy and Clinical Immunology. 111: S152. DOI: 10.1016/S0091-6749(03)80489-X  0.339
2002 Stephens R, Randolph DA, Huang G, Holtzman MJ, Chaplin DD. Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma. Journal of Immunology (Baltimore, Md. : 1950). 169: 5458-67. PMID 12421921 DOI: 10.4049/Jimmunol.169.10.5458  0.44
2002 Walter MJ, Morton JD, Kajiwara N, Agapov E, Holtzman MJ. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. The Journal of Clinical Investigation. 110: 165-75. PMID 12122108 DOI: 10.1172/Jci14345  0.466
2002 Holtzman MJ, Morton JD, Shornick LP, Tyner JW, O'Sullivan MP, Antao A, Lo M, Castro M, Walter MJ. Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm. Physiological Reviews. 82: 19-46. PMID 11773608 DOI: 10.1152/Physrev.00020.2001  0.766
2002 Grayson MH, Holtzman MJ. Lessons from allergic rhinitis versus asthma pathogenesis and treatment Immunology and Allergy Clinics of North America. 22: 845-869. DOI: 10.1016/S0889-8561(02)00027-9  0.447
2001 Walter MJ, Kajiwara N, Karanja P, Castro M, Holtzman MJ. Interleukin 12 p40 production by barrier epithelial cells during airway inflammation Journal of Experimental Medicine. 193: 339-351. PMID 11157054 DOI: 10.1084/Jem.193.3.339  0.404
2000 Castro M, Chaplin DD, Walter MJ, Holtzman MJ. Could asthma be worsened by stimulating the T-helper type 1 immune response? American Journal of Respiratory Cell and Molecular Biology. 22: 143-146. PMID 10657933 DOI: 10.1165/Ajrcmb.22.2.F174  0.412
1999 Koga T, Sardiña E, Tidwell RM, Pelletier M, Look DC, Holtzman MJ. Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization Proceedings of the National Academy of Sciences of the United States of America. 96: 5680-5685. PMID 10318944 DOI: 10.1073/Pnas.96.10.5680  0.398
1999 Sampath D, Castro M, Look DC, Holtzman MJ. Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. The Journal of Clinical Investigation. 103: 1353-61. PMID 10225979 DOI: 10.1172/JCI6130  0.308
1998 Look DC, Roswit WT, Frick AG, Gris-Alevy Y, Dickhaus DM, Walter MJ, Holtzman MJ. Direct suppression of Stat1 function during adenoviral infection. Immunity. 9: 871-80. PMID 9881977 DOI: 10.1016/S1074-7613(00)80652-4  0.364
1998 Taguchi M, Sampath D, Koga T, Castro M, Look DC, Nakajima S, Holtzman MJ. Patterns for RANTES secretion and intercellular adhesion molecule 1 expression mediate transepithelial T cell traffic based on analyses in vitro and in vivo. The Journal of Experimental Medicine. 187: 1927-40. PMID 9625753 DOI: 10.1084/Jem.187.12.1927  0.384
1998 Holtzman MJ, Look DC, Sampath D, Castro M, Koga T, Walter MJ. Control of epithelial immune-response genes and implications for airway immunity and inflammation. Proceedings of the Association of American Physicians. 110: 1-11. PMID 9460078  0.41
1998 Walter MJ, Kajiwara N, Sampath D, Rucker J, Holtzman MJ. Induction of epithelial immune-response genes in a mouse model of viral bronchitis and hyperreactivity Faseb Journal. 12.  0.394
1997 Walter MJ, Look DC, Tidwell RM, Roswit WT, Holtzman MJ. Targeted inhibition of interferon-γ-dependent intercellular adhesion molecule-1 (ICAM-1) expression using dominant-negative Stat1 Journal of Biological Chemistry. 272: 28582-28589. PMID 9353323 DOI: 10.1074/Jbc.272.45.28582  0.361
1996 Holtzman MJ, Sampath D, Castro M, Look DC, Jayaraman S. The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma? American Journal of Respiratory Cell and Molecular Biology. 14: 316-8. PMID 8600934 DOI: 10.1165/Ajrcmb.14.4.8600934  0.417
1995 Holtzman MJ, Brody SL, Look DC. Does gene therapy call for "STAT" immunity and inflammation at the epithelial barrier? American Journal of Respiratory Cell and Molecular Biology. 12: 127-129. PMID 7865211 DOI: 10.1165/Ajrcmb.12.2.7865211  0.437
1994 Holtzman MJ, Zhang V, Hussain H, Roswit WT, Wilson JD. Prostaglandin H synthase and lipoxygenase gene families in the epithelial cell barrier. Annals of the New York Academy of Sciences. 744: 58-77. PMID 7825863 DOI: 10.1111/J.1749-6632.1994.Tb52724.X  0.327
1993 Shannon VR, Chanez P, Bousquet J, Holtzman MJ. Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease American Review of Respiratory Disease. 147: 1024-1028. PMID 8466102 DOI: 10.1164/Ajrccm/147.4.1024  0.358
1993 Shannon VR, Stenson WF, Holtzman MJ. Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease American Journal of Physiology - Gastrointestinal and Liver Physiology. 264. PMID 7679252 DOI: 10.1152/Ajpgi.1993.264.1.G104  0.325
1992 Holtzman MJ. Arachidonic acid metabolism in airway epithelial cells Annual Review of Physiology. 54: 303-329. PMID 1562177 DOI: 10.1146/Annurev.Ph.54.030192.001511  0.35
1992 Holtzman MJ, Look DC. Cell adhesion molecules as targets for unraveling the genetic regulation of airway inflammation American Journal of Respiratory Cell and Molecular Biology. 7: 246-247. PMID 1520488 DOI: 10.1165/Ajrcmb/7.3.246  0.324
1992 Look DC, Rapp SR, Keller BT, Holtzman MJ. Selective induction of intercellular adhesion molecule-1 by interferon-γ in human airway epithelial cells American Journal of Physiology - Lung Cellular and Molecular Physiology. 263. PMID 1353306 DOI: 10.1152/Ajplung.1992.263.1.L79  0.383
1991 Shannon VR, Crouch EC, Takahashi Y, Ueda N, Yamamoto S, Holtzman MJ. Related expression of arachidonate 12- and 15-lipoxygenases in animal and human lung tissue American Journal of Physiology - Lung Cellular and Molecular Physiology. 261. PMID 1767860 DOI: 10.1152/Ajplung.1991.261.6.L399  0.337
1989 Holtzman MJ, Pentland A, Baenziger NL, Hansbrough JR. Heterogeneity of cellular expression of arachidonate 15-lipoxygenase: implications for biological activity. Biochimica Et Biophysica Acta. 1003: 204-8. PMID 2730892 DOI: 10.1016/0005-2760(89)90257-9  0.314
Low-probability matches (unlikely to be authored by this person)
1996 Zhang V, O'Sullivan M, Hussain H, Roswit WT, Holtzman MJ. Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2. Biochemical and Biophysical Research Communications. 227: 499-506. PMID 8878543 DOI: 10.1006/Bbrc.1996.1536  0.299
2014 Demehri S, Yockey LJ, Visness CM, Jaffee KF, Turkoz A, Wood RA, O'Connor GT, Kattan M, Gern JE, Gergen PJ, Holtzman M, Bloomberg G, Kopan R. Circulating TSLP associates with decreased wheezing in non-atopic preschool children: data from the URECA birth cohort. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 44: 851-7. PMID 24397611 DOI: 10.1111/Cea.12270  0.298
2015 Barrow AD, Palarasah Y, Bugatti M, Holehouse AS, Byers DE, Holtzman MJ, Vermi W, Skjødt K, Crouch E, Colonna M. OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes. Journal of Immunology (Baltimore, Md. : 1950). 194: 3317-26. PMID 25716998 DOI: 10.4049/Jimmunol.1402289  0.298
1991 Holtzman MJ, Ferdman B, Bohrer A, Turk J. Synthesis of the 1-O-hexadecyl molecular species of platelet-activating factor by airway epithelial and vascular endothelial cells. Biochemical and Biophysical Research Communications. 177: 357-64. PMID 2043121 DOI: 10.1016/0006-291X(91)91991-K  0.298
2022 Blackburn JB, Schaff JA, Gutor S, Du RH, Nichols D, Sherrill T, Gutierrez AJ, Xin MK, Wickersham N, Zhang Y, Holtzman MJ, Ware LB, Banovich NE, Kropski JA, Blackwell TS, et al. Secretory Cells are the Primary Source of pIgR in Small Airways. American Journal of Respiratory Cell and Molecular Biology. PMID 35687143 DOI: 10.1165/rcmb.2021-0548OC  0.295
2023 Keeler SP, Wu K, Zhang Y, Mao D, Li M, Iberg CA, Austin SR, Glaser SA, Yantis J, Podgorny S, Brody SL, Chartock JR, Han Z, Byers DE, Romero AG, ... Holtzman MJ, et al. A new MAPK13-guided inhibitor for respiratory inflammation and mucus production. Biorxiv : the Preprint Server For Biology. PMID 37292761 DOI: 10.1101/2023.05.26.542451  0.295
1994 Nakajima S, Look DC, Roswit WT, Bragdon MJ, Holtzman MJ. Selective differences in vascular endothelial- vs. airway epithelial-T cell adhesion mechanisms American Journal of Physiology - Lung Cellular and Molecular Physiology. 267. PMID 7524353 DOI: 10.1152/Ajplung.1994.267.4.L422  0.295
2018 Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS. Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease. The Journal of Clinical Investigation. PMID 30137026 DOI: 10.1172/Jci120453  0.294
2007 Kwon MJ, Yao Y, Walter MJ, Holtzman MJ, Chang CH. Role of PKCdelta in IFN-gamma-inducible CIITA gene expression. Molecular Immunology. 44: 2841-9. PMID 17346795 DOI: 10.1016/J.Molimm.2007.01.035  0.294
2003 Holtzman MJ. Where are the gaps in asthma research? A counter-perspective. The Journal of Allergy and Clinical Immunology. 111: 244-7. PMID 12589339 DOI: 10.1067/Mai.2003.141  0.294
2020 Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang E, Klein EM, Goldey GJ, He K, ... ... Holtzman MJ, et al. Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. Neuron. PMID 32961128 DOI: 10.1016/J.Neuron.2020.08.024  0.293
2004 Chang YJ, Holtzman MJ, Chen CC. Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1. Molecular Pharmacology. 65: 589-98. PMID 14978237 DOI: 10.1124/Mol.65.3.589  0.293
1994 Dean DC, Weintraub SJ, Holtzman MJ. A molecular switch between lung development and cancer: is the tumor suppressor Rb turned on during bronchial epithelial cell differentiation and turned off in small cell lung cancer? American Journal of Respiratory Cell and Molecular Biology. 11: 249-50. PMID 8086162 DOI: 10.1165/Ajrcmb.11.3.8086162  0.292
2010 Deslee G, Adair-Kirk TL, Betsuyaku T, Woods JC, Moore CH, Gierada DS, Conradi SH, Atkinson JJ, Toennies HM, Battaile JT, Kobayashi DK, Patterson GA, Holtzman MJ, Pierce RA. Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts. American Journal of Respiratory Cell and Molecular Biology. 43: 576-84. PMID 20008282 DOI: 10.1165/Rcmb.2009-0221Oc  0.292
2000 Holtzman MJ, Green JM, Jayaraman S, Arch RH. Regulation of T cell apoptosis Apoptosis. 5: 459-471. PMID 11256889 DOI: 10.1023/A:1009657321461  0.292
1991 Holtzman MJ. Arachidonic acid metabolism: Implications of biological chemistry for lung function and disease American Review of Respiratory Disease. 143: 188-203. PMID 1898844 DOI: 10.1164/Ajrccm/143.1.188  0.29
2002 Chang YJ, Holtzman MJ, Chen CC. Interferon-gamma-induced epithelial ICAM-1 expression and monocyte adhesion. Involvement of protein kinase C-dependent c-Src tyrosine kinase activation pathway. The Journal of Biological Chemistry. 277: 7118-26. PMID 11751911 DOI: 10.1074/Jbc.M109924200  0.289
2022 Chong Z, Karl CE, Halfmann PJ, Kawaoka Y, Winkler ES, Keeler SP, Holtzman MJ, Yu J, Diamond MS. Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron. Cell Reports. 39: 110799. PMID 35523172 DOI: 10.1016/j.celrep.2022.110799  0.289
2005 Grayson M, Rohlfing M, Ramos M, Holtzman M. CCL5-deficient lung DC subsets promote greater CD8 T cell proliferation Journal of Allergy and Clinical Immunology. 115: S117. DOI: 10.1016/J.Jaci.2004.12.481  0.288
2023 Keeler SP, Wu K, Zhang Y, Mao D, Li M, Iberg CA, Austin SR, Glaser SA, Yantis J, Podgorny S, Brody SL, Chartock JR, Han Z, Byers DE, Romero AG, ... Holtzman MJ, et al. A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 37847710 DOI: 10.1152/ajplung.00183.2023  0.286
2003 Huang Xl, Pawliczak R, Yao Xl, Cowan MJ, Gladwin MT, Walter MJ, Holtzman MJ, Madara P, Logun C, Shelhamer JH. Interferon-γ induces p11 gene and protein expression in human epithelial cells through interferon-γ-activated sequences in the p11 promoter Journal of Biological Chemistry. 278: 9298-9308. PMID 12645529 DOI: 10.1074/Jbc.M212704200  0.286
1983 Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA. Effect of route of atropine delivery on bronchospasm from cold air and methacholine Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 54: 130-133. PMID 6337982 DOI: 10.1152/Jappl.1983.54.1.130  0.285
2012 Lobas MA, Helsper L, Vernon CG, Schreiner D, Zhang Y, Holtzman MJ, Thedens DR, Weiner JA. Molecular heterogeneity in the choroid plexus epithelium: the 22-member γ-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation. Journal of Neurochemistry. 120: 913-27. PMID 22092001 DOI: 10.1111/J.1471-4159.2011.07587.X  0.285
1988 Holtzman MJ, Hansbrough JR, Rosen GD, Turk J. Uptake, release and novel species-dependent oxygenation of arachidonic acid in human and animal airway epithelial cells. Biochimica Et Biophysica Acta. 963: 401-13. PMID 2848586 DOI: 10.1016/0005-2760(88)90308-6  0.284
1980 Holtzman MJ, Sheller JR, Dimeo M, Nadel JA, Boushey HA. Effect of ganglionic blockade on bronchial reactivity in atopic subjects American Review of Respiratory Disease. 122: 17-25. PMID 6105834 DOI: 10.1164/Arrd.1980.122.1.17  0.283
2015 Lun MP, Johnson MB, Broadbelt KG, Watanabe M, Kang YJ, Chau KF, Springel MW, Malesz A, Sousa AM, Pletikos M, Adelita T, Calicchio ML, Zhang Y, Holtzman MJ, Lidov HG, et al. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4903-16. PMID 25810521 DOI: 10.1523/Jneurosci.3081-14.2015  0.282
2000 Shen X, Tian Z, Holtzman MJ, Gao B. Cross-talk between interleukin 1β (IL-1β) and IL-6 signalling pathways: IL-1β selectively inhibits IL-6-activated signal transducer and activator of transcription factor 1 (STAT1) by a proteasome-dependent mechanism Biochemical Journal. 352: 913-919. PMID 11104703 DOI: 10.1042/Bj3520913  0.281
1994 Hussain H, Shornick LP, Shannon VR, Wilson JD, Funk CD, Pentland AP, Holtzman MJ. Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. The American Journal of Physiology. 266: C243-53. PMID 8304420 DOI: 10.1152/Ajpcell.1994.266.1.C243  0.281
2015 Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, ... ... Holtzman MJ, et al. PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. Nature Immunology. PMID 26479788 DOI: 10.1038/Ni.3279  0.281
1989 Hansbrough JR, Atlas AB, Turk J, Holtzman MJ. Arachidonate 12-lipoxygenase and cyclooxygenase: PGE isomerase are predominant pathways for oxygenation in bovine tracheal epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 1: 237-44. PMID 2516452 DOI: 10.1165/Ajrcmb/1.3.237  0.28
1989 Rosen GD, Birkenmeier TM, Raz A, Holtzman MJ. Identification of a cyclooxygenase-related gene and its potential role in prostaglandin formation. Biochemical and Biophysical Research Communications. 164: 1358-65. PMID 2480117 DOI: 10.1016/0006-291X(89)91819-6  0.277
2020 Case JB, Rothlauf PW, Chen RE, Kafai NM, Fox JM, Shrihari S, McCune BT, Harvey IB, Smith B, Keeler SP, Bloyet LM, Winkler ES, Holtzman MJ, Fremont DH, Whelan SPJ, et al. Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis. Biorxiv : the Preprint Server For Biology. PMID 32676597 DOI: 10.1101/2020.07.09.196386  0.275
2007 Cheung D, Rohlfing M, Kitchens R, Holtzman M, Grayson M. Cross-linking of FcεRI on Dendritic Cells Skews CD4+ T cells towards a TH17 Phenotype Journal of Allergy and Clinical Immunology. 119: S209. DOI: 10.1016/J.Jaci.2006.12.189  0.273
2016 Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ. Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. Elife. 5. PMID 27995897 DOI: 10.7554/Elife.20391  0.273
1989 Holtzman MJ, Turk J, Pentland A. A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells. The Journal of Clinical Investigation. 84: 1446-53. PMID 2509517 DOI: 10.1172/Jci114319  0.273
2017 Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K. Epithelial Chloride Transport by CFTR Requires TMEM16A. Scientific Reports. 7: 12397. PMID 28963502 DOI: 10.1038/S41598-017-10910-0  0.271
2020 Lemeille S, Paschaki M, Baas D, Morlé L, Duteyrat JL, Ait-Lounis A, Barras E, Soulavie F, Jerber J, Thomas J, Zhang Y, Holtzman MJ, Kistler WS, Reith W, Durand B. Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis. Nucleic Acids Research. PMID 32725242 DOI: 10.1093/Nar/Gkaa625  0.27
2003 Grayson MH, Hotchkiss RS, Karl IE, Holtzman MJ, Chaplin DD. Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node. American Journal of Physiology. Heart and Circulatory Physiology. 284: H2213-26. PMID 12586641 DOI: 10.1152/Ajpheart.00999.2002  0.268
1982 Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA. Dose-dependent inhibition of cold air-induced bronchoconstriction by atropine Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 53: 169-174. PMID 6749773 DOI: 10.1152/Jappl.1982.53.1.169  0.267
2016 Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ. First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. Biochimica Et Biophysica Acta. PMID 27369736 DOI: 10.1016/J.Bbagen.2016.06.023  0.266
2014 Ebbinghaus M, Gajda M, Holtzman MJ, Schulz S, Schaible HG. Does chloride channel accessory 3 have a role in arthritis pain? A study on murine antigen-induced arthritis. Neuroscience Letters. 576: 40-4. PMID 24905173 DOI: 10.1016/J.Neulet.2014.05.051  0.266
2020 Bricker TL, Darling TL, Hassan AO, Harastani HH, Soung A, Jiang X, Dai YN, Zhao H, Adams LJ, Holtzman MJ, Bailey AL, Case JB, Fremont DH, Klein R, Diamond MS, et al. A single intranasal or intramuscular immunization with chimpanzee adenovirus vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters. Biorxiv : the Preprint Server For Biology. PMID 33299991 DOI: 10.1101/2020.12.02.408823  0.266
2018 Coverstone AM, Wilson BS, Burgdorf D, Schechtman KB, Storch GA, Holtzman MJ, Castro M, Bacharier LB, Sumino K. Recurrent Wheezing in Children Following Human Metapneumovirus Infection. The Journal of Allergy and Clinical Immunology. PMID 29481834 DOI: 10.1016/J.Jaci.2018.02.008  0.265
1981 Dimeo MJ, Glenn MG, Holtzman MJ, Sheller JR, Nadel JA, Boushey HA. Threshold concentration of ozone causing an increase in bronchial reactivity in humans and adaptation with repeated exposures American Review of Respiratory Disease. 124: 245-248. PMID 6169298 DOI: 10.1164/Arrd.1981.124.3.245  0.265
2016 Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ. Author response: Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms Elife. DOI: 10.7554/Elife.20391.021  0.263
2005 Holtzman MJ. Airway responses to respiratory viruses: Chairman's summary Proceedings of the American Thoracic Society. 2: 108-109. DOI: 10.1513/pats.200506-050AW  0.261
2022 Keeler SP, Yantis J, Gerovac BJ, Youkilis SL, Podgorny S, Mao D, Zhang Y, Whitworth KM, Redel B, Samuel MS, Wells KD, Prather RS, Holtzman MJ. Chloride channel accessory 1 (CLCA1) gene deficiency causes selective loss of mucus production in a new pig model. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 35438004 DOI: 10.1152/ajplung.00443.2021  0.261
2006 Ibricevic A, Pekosz A, Walter MJ, Newby C, Battaile JT, Brown EG, Holtzman MJ, Brody SL. Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells. Journal of Virology. 80: 7469-80. PMID 16840327 DOI: 10.1128/Jvi.02677-05  0.259
1983 Holtzman MJ, Fabbri LM, O'Byrne PM, Gold BD, Aizawa H, Walters EH, Alpert SE, Nadel JA. Importance of airway inflammation for hyperresponsiveness induced by ozone American Review of Respiratory Disease. 127: 686-690. PMID 6859651  0.258
2021 Bricker TL, Darling TL, Hassan AO, Harastani HH, Soung A, Jiang X, Dai YN, Zhao H, Adams LJ, Holtzman MJ, Bailey AL, Case JB, Fremont DH, Klein R, Diamond MS, et al. A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters. Cell Reports. 109400. PMID 34245672 DOI: 10.1016/j.celrep.2021.109400  0.256
2012 Brown SM, Campbell SD, Crafford A, Regina KJ, Holtzman MJ, Kharasch ED. P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception. The Journal of Pharmacology and Experimental Therapeutics. 343: 53-61. PMID 22739506 DOI: 10.1124/Jpet.112.193433  0.256
2021 Winkler ES, Chen RE, Alam F, Yildiz S, Case JB, Uccellini MB, Holtzman MJ, Garcia-Sastre A, Schotsaert M, Diamond MS. SARS-CoV-2 causes lung infection without severe disease in human ACE2 knock-in mice. Journal of Virology. JVI0151121. PMID 34668780 DOI: 10.1128/JVI.01511-21  0.255
1982 Sheller JR, Holtzman MJ, Skoogh BE, Nadel JA. Interaction of serotonin with vagal- and ACh-induced bronchoconstriction in canine lungs Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 52: 964-966. PMID 7085430 DOI: 10.1152/Jappl.1982.52.4.964  0.255
2023 Martin RA, Keeler SP, Wu K, Shearon WJ, Patel D, Li J, Hoang M, Hoffmann CM, Hughes ME, Holtzman MJ. An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 37130808 DOI: 10.1152/ajplung.00338.2022  0.255
2022 Martin RA, Keeler SP, Wu K, Shearon WJ, Patel D, Hoang M, Hoffmann CM, Hughes ME, Holtzman MJ. An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease. Biorxiv : the Preprint Server For Biology. PMID 36238722 DOI: 10.1101/2022.10.07.511313  0.255
1985 Boushey HA, Holtzman MJ. Experimental airway inflammation and hyperreactivity. Searching for cells and mediators American Review of Respiratory Disease. 131: 312-313. PMID 3977169  0.254
1998 Sardifia E, Tidwell R, Koga T, Holtzman MJ. Regulation of rantes gene expression by a 3′-utr that lacks consensus sites for mrna turnover Faseb Journal. 12.  0.251
2011 Patel AC, Brody SL, Stappenbeck TS, Holtzman MJ. Tracking cell lineage to rediscover (again) the switch from ciliated to mucous cells. American Journal of Respiratory Cell and Molecular Biology. 44: 261-3. PMID 21364232 DOI: 10.1165/Rcmb.2010-0468Ed  0.246
1990 Holtzman MJ. Mechanisms of lipid mediator release in airway epithelial cells Immunology and Allergy Clinics of North America. 10: 309-318.  0.245
1990 Pentland AP, Mahoney M, Jacobs SC, Holtzman MJ. Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema. The Journal of Clinical Investigation. 86: 566-74. PMID 1696589 DOI: 10.1172/Jci114746  0.243
1992 Shannon VR, Ramanadham S, Turk J, Holtzman MJ. Selective expression of an arachidonate 12-lipoxygenase by pancreatic islet β-cells American Journal of Physiology - Endocrinology and Metabolism. 263. PMID 1443114 DOI: 10.1152/Ajpendo.1992.263.5.E828  0.242
2011 Brown SM, Holtzman M, Kim T, Kharasch ED. Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active. Anesthesiology. 115: 1251-60. PMID 22037640 DOI: 10.1097/Aln.0B013E318238Fea0  0.241
2009 Demehri S, Morimoto M, Holtzman MJ, Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. Plos Biology. 7: e1000067. PMID 19557146 DOI: 10.1371/Journal.Pbio.1000067  0.24
2017 Li S, O'Neill SR, Zhang Y, Holtzman MJ, Takemaru KI, Korach KS, Winuthayanon W. Estrogen receptor α is required for oviductal transport of embryos. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28082352 DOI: 10.1096/Fj.201601128R  0.238
2007 Cohen L, E X, Tarsi J, Ramkumar T, Horiuchi TK, Cochran R, DeMartino S, Schechtman KB, Hussain I, Holtzman MJ, Castro M. Epithelial cell proliferation contributes to airway remodeling in severe asthma. American Journal of Respiratory and Critical Care Medicine. 176: 138-45. PMID 17463414 DOI: 10.1164/rccm.200607-1062OC  0.232
2009 Deslee G, Woods JC, Moore C, Conradi SH, Gierada DS, Atkinson JJ, Battaile JT, Liu L, Patterson GA, Adair-Kirk TL, Holtzman MJ, Pierce RA. Oxidative damage to nucleic acids in severe emphysema. Chest. 135: 965-74. PMID 19118262 DOI: 10.1378/Chest.08-2257  0.229
2011 Jacquet BV, Muthusamy N, Sommerville LJ, Xiao G, Liang H, Zhang Y, Holtzman MJ, Ghashghaei HT. Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9368-82. PMID 21697387 DOI: 10.1523/Jneurosci.0171-11.2011  0.227
2001 Anderson GJ, Roswit WT, Holtzman MJ, Hogg JC, Van Eeden SF. Effect of mechanical deformation of neutrophils on their CD18/ICAM-1-dependent adhesion Journal of Applied Physiology. 91: 1084-1090. PMID 11509502 DOI: 10.1152/Jappl.2001.91.3.1084  0.227
2015 Yurtsever Z, Scheaffer SM, Romero AG, Holtzman MJ, Brett TJ. The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation. Acta Crystallographica. Section D, Biological Crystallography. 71: 790-9. PMID 25849390 DOI: 10.1107/S1399004715001212  0.227
2015 Huang PH, Ren L, Nama N, Li S, Li P, Yao X, Cuento RA, Wei CH, Chen Y, Xie Y, Nawaz AA, Alevy YG, Holtzman MJ, McCoy JP, Levine SJ, et al. An acoustofluidic sputum liquefier. Lab On a Chip. 15: 3125-31. PMID 26082346 DOI: 10.1039/C5Lc00539F  0.222
2021 Chatterjee J, Sanapala S, Cobb O, Bewley A, Goldstein AK, Cordell E, Ge X, Garbow JR, Holtzman MJ, Gutmann DH. Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia. Nature Communications. 12: 7122. PMID 34880260 DOI: 10.1038/s41467-021-27455-6  0.219
1984 Fabbri LM, Aizawa H, Alpert SE, Walters EH, O'Byrne PM, Gold BD, Nadel JA, Holtzman MJ. Airway hyperresponsiveness and changes in cell counts in bronchoalveolar lavage after ozone exposure in dogs American Review of Respiratory Disease. 129: 288-291. PMID 6696327  0.217
2020 Rao L, De La Rosa I, Xu Y, Sha Y, Bhattacharya A, Holtzman MJ, Gilbert BE, Eissa NT. Pseudomonas aeruginosa survives in epithelia by ExoS-mediated inhibition of autophagy and mTOR. Embo Reports. e50613. PMID 33345425 DOI: 10.15252/embr.202050613  0.216
2002 Grayson MH, Holtzman MJ, Chaplin DD. Distinct characteristics of T cell rolling and adhesion in splenic versus lymph node vessels Journal of Allergy and Clinical Immunology. 109: S318-S318. DOI: 10.1016/S0091-6749(02)82116-9  0.216
1999 Jayaraman S, Castro M, O'Sullivan M, Bragdon MJ, Holtzman MJ. Resistance to Fas-mediated T cell apoptosis in asthma Journal of Immunology. 162: 1717-1722. PMID 9973434  0.215
1994 Look DC, Pelletier MR, Holtzman MJ. Selective interaction of a subset of interferon-γ response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells Journal of Biological Chemistry. 269: 8952-8958. PMID 7907595  0.213
1987 Holtzman MJ. Species-specificity of lipoxygenase and cyclooxygenase activities expressed in pulmonary airway epithelial cells Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 17: 177-179. PMID 2959043  0.21
1984 O'Byrne PM, Aizawa H, Bethel RA, Chung KF, Nadel JA, Holtzman MJ. Prostaglandin F2α increases responsiveness of pulmonary airways in dogs Prostaglandins. 28: 537-543. PMID 6596652 DOI: 10.1016/0090-6980(84)90242-9  0.208
2018 Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T. The choroid plexus is an important circadian clock component. Nature Communications. 9: 1062. PMID 29540683 DOI: 10.1038/S41467-018-03507-2  0.204
2016 Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA. Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation. Molecular and Cellular Neurosciences. PMID 27751903 DOI: 10.1016/J.Mcn.2016.10.004  0.202
1982 Skoogh BE, Holtzman MJ, Sheller JR, Nadel JA. Barbiturates depress vagal motor pathway to ferret trachea at ganglia Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 53: 253-257. PMID 7118638 DOI: 10.1152/Jappl.1982.53.1.253  0.2
2024 Durstenfeld MS, Weiman S, Holtzman M, Blish C, Pretorius R, Deeks SG. Long COVID and post-acute sequelae of SARS-CoV-2 pathogenesis and treatment: A Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 38593220 DOI: 10.1111/nyas.15132  0.199
1980 Boushey HA, Holtzman MJ, Sheller JR, Nadel JA. Bronchial hyperreactivity American Review of Respiratory Disease. 121: 389-413. PMID 6987924  0.197
2011 Fu H, Patel AC, Holtzman MJ, Chen DR. A New Electrospray Aerosol Generator with High Particle Transmission Efficiency. Aerosol Science and Technology : the Journal of the American Association For Aerosol Research. 45: 1176-1183. PMID 22829715 DOI: 10.1080/02786826.2011.582899  0.197
2000 Holtzman MJ. Perennial goals for the millennium American Journal of Respiratory Cell and Molecular Biology. 23: 1-2. PMID 10873145 DOI: 10.1165/Ajrcmb.23.1.2314  0.192
2019 Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T. Author Correction: The choroid plexus is an important circadian clock component. Nature Communications. 10: 5253. PMID 31748545 DOI: 10.1038/S41467-019-13101-9  0.191
1991 Shannon VR, Hansbrough JR, Takahashi Y, Ueda N, Yamamoto S, Holtzman MJ. Biochemical and immunohistochemical evidence for selective expression of novel epithelial lipoxygenases Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 21: 37-40. PMID 1825573  0.19
1983 Holtzman MJ, Fabbri LM, Skoogh BE, O'Byrne PM, Walters EH, Aizawa H, Nadel JA. Time course of airway hyperresponsiveness induced by ozone in dogs Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 55: 1232-1236. PMID 6629955  0.187
2002 Holtzman MJ. Improving peer review and introducing translational review American Journal of Respiratory Cell and Molecular Biology. 27: 1-2. DOI: 10.1165/Ajrcmb.27.1.F242  0.185
1984 O'Byrne PM, Walters EH, Aizawa H, Fabbri LM, Holtzman MJ, Nadel JA. Indomethacin inhibits the airway hyperresponsiveness but not the neutrophil influx induced by ozone in dogs American Review of Respiratory Disease. 130: 220-224. PMID 6465676  0.179
1984 O'Byrne PM, Walters EH, Gold BD, Aizawa HA, Fabbri LM, Alpert SE, Nadel JA, Holtzman MJ. Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure American Review of Respiratory Disease. 130: 214-219. PMID 6465675  0.173
1998 Holtzman MJ. Matching scientific with societal interests: charges for the new editor American Journal of Respiratory Cell and Molecular Biology. 19: 1-2. PMID 9651173 DOI: 10.1165/Ajrcmb.19.1.1914  0.171
2014 Adler KB, Shapiro SD, Holtzman MJ, McDonald JA. The Red journal at 25 years. Looking back and looking ahead. American Journal of Respiratory Cell and Molecular Biology. 50: 839-40. PMID 24783952 DOI: 10.1165/Rcmb.2014-0104Ed  0.171
2021 Chen DL, Agapov E, Wu K, Engle JT, Solingapuram Sai KK, Arentson E, Spayd KJ, Moreland KT, Toth K, Byers DE, Pierce RA, Atkinson JJ, Laforest R, Gelman AE, Holtzman MJ. Selective Imaging of Lung Macrophages Using [C]PBR28-Based Positron Emission Tomography. Molecular Imaging and Biology. PMID 34137002 DOI: 10.1007/s11307-021-01617-w  0.169
2001 Holtzman MJ. Electronics, people, and the art of publication American Journal of Respiratory Cell and Molecular Biology. 25: 1-2. DOI: 10.1165/Ajrcmb.25.1.2511  0.169
2003 Holtzman MJ. Transition, sunlight, and the art of journal maintenance. American Journal of Respiratory Cell and Molecular Biology. 29: 1-2. PMID 12821444 DOI: 10.1165/Rcmb.F275  0.169
1986 Seltzer J, Bigby BG, Stulbarg M, Holtzman MJ, Nadel JA, Ueki IF, Leikauf GD, Goetzl EJ, Boushey HA. O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. Journal of Applied Physiology (Bethesda, Md. : 1985). 60: 1321-6. PMID 3084448 DOI: 10.1152/Jappl.1986.60.4.1321  0.169
1985 Fabbri LM, Aizawa H, O'Byrne PM, Bethel RA, Walters EH, Holtzman MJ, Nadel JA. An anti-inflammatory drug (BW755C) inhibits airway hyperresponsiveness induced by ozone in dogs The Journal of Allergy and Clinical Immunology. 76: 162-166. PMID 3926851 DOI: 10.1016/0091-6749(85)90695-5  0.166
1986 O'Byrne PM, Leikauf GD, Aizawa H, Bethel RA, Ueki IF, Holtzman MJ, Nadel JA. Leukotriene B4 induces airway hyperresponsiveness in dogs. Journal of Applied Physiology (Bethesda, Md. : 1985). 59: 1941-6. PMID 3001017 DOI: 10.1152/Jappl.1985.59.6.1941  0.164
1992 Holtzman MJ, Turk J, Shornick LP. Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells Journal of Biological Chemistry. 267: 21438-21445. PMID 1400457  0.164
1981 Holtzman MJ, Nadel JA. Treatment of asthma and bronchoconstriction Rational Drug Therapy. 15. PMID 6819593  0.163
2005 Holtzman MJ, Kim EY, Morton JD. Genetic and genomic approaches to complex lung diseases using mouse models Computational Genetics and Genomics: Tools For Understanding Disease. 103-145. DOI: 10.1007/978-1-59259-930-1_6  0.161
1995 Look DC, Pelletier MB, Tidwell RM, Roswit WT, Holtzman MJ. Stat1 depends on transcriptional synergy with Sp1 Journal of Biological Chemistry. 270: 30264-30267. PMID 8530443 DOI: 10.1074/jbc.270.51.30264  0.151
2010 Edelson BT, KC W, Juang R, Kohyama M, Benoit LA, Klekotka PA, Moon C, Albring JC, Ise W, Michael DG, Bhattacharya D, Stappenbeck TS, Holtzman MJ, Sung SS, Murphy TL, et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. The Journal of Experimental Medicine. 207: 823-36. PMID 20351058 DOI: 10.1084/Jem.20091627  0.146
1995 Nakajima S, Roswit WT, Look DC, Holtzman MJ. A hierarchy for integrin expression and adhesiveness among T cell subsets that is linked to TCR gene usage and emphasizes Vδ1+ γδ T cell adherence and tissue retention Journal of Immunology. 155: 1117-1131. PMID 7636183  0.145
1985 Hunter JA, Finkbeiner WE, Nadel JA, Goetzl EJ, Holtzman MJ. Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea Proceedings of the National Academy of Sciences of the United States of America. 82: 4633-4637. PMID 3927287 DOI: 10.1073/pnas.82.14.4633  0.145
2023 McGlade EA, Stephens KK, Winuthayanon S, Anamthathmakula P, Holtzman MJ, Winuthayanon W. Classical estrogen signaling in ciliated epithelial cells of the oviduct is nonessential for fertility in female mice. Endocrinology. PMID 37942801 DOI: 10.1210/endocr/bqad163  0.141
1987 Sigal CE, Valone FH, Holtzman MJ, Goetzl EJ. Preferential human eosinophil chemotactic activity of the platelet-activating factor (PAF) 1-0-hexadecyl-2-acetyl-sn-glyceryl-3-phosphocholine (AGEPC) Journal of Clinical Immunology. 7: 179-184. PMID 3571436 DOI: 10.1007/BF00916012  0.137
1987 Bigby TD, Holtzman MJ. Enhanced 5-lipoxygenase activity in lung macrophages compared to monocytes from normal subjects Journal of Immunology. 138: 1546-1550. PMID 3027181  0.134
1993 Shornick LP, Holtzman MJ. A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells Journal of Biological Chemistry. 268: 371-376. PMID 8416945  0.131
2006 Lin W, Kim SS, Yeung E, Kamegaya Y, Blackard JT, Kim KA, Holtzman MJ, Chung RT. Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. Journal of Virology. 80: 9226-35. PMID 16940534 DOI: 10.1128/Jvi.00459-06  0.128
1983 Holtzman MJ, McNamara MP, Sheppard D, Fabbri LM, Hahn HL, Graf PD, Nadel JA. Intravenous versus inhaled atropine for inhibiting bronchoconstrictor responses in dogs. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 54: 134-9. PMID 6826397 DOI: 10.1152/Jappl.1983.54.1.134  0.127
2010 Poat B, Hazari S, Chandra PK, Gunduz F, Balart LA, Alvarez X, Zhang Y, Holtzman MJ, Dash S. Correction: SH2 Modified STAT1 Induces HLA-I Expression and Improves IFN-γ Signaling in IFN-α Resistant HCV Replicon Cells Plos One. 5. DOI: 10.1371/annotation/ff8fe1fe-36ae-43fe-9350-8ba2f191331a  0.125
1986 Holtzman MJ. Lipoxgenation of arachidonic acid in tracheal epithelial cells Clinical Respiratory Physiology. 22: 38.  0.125
2023 Trier AM, Heul AV, Fredman A, Le V, Wang Z, Auyeung K, Meixiong J, Lovato P, Holtzman MJ, Wang F, Dong X, Ji AL, Kim BS. IL-33 Potentiates Histaminergic Itch. The Journal of Allergy and Clinical Immunology. PMID 37984799 DOI: 10.1016/j.jaci.2023.08.038  0.124
2021 Ito N, Riyadh MA, Ahmad SAI, Hattori S, Kanemura Y, Kiyonari H, Abe T, Furuta Y, Shinmyo Y, Kaneko N, Hirota Y, Lupo G, Hatakeyama J, Abdulhaleem M FA, Anam MB, ... ... Holtzman MJ, et al. Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice. Science Translational Medicine. 13. PMID 33790026 DOI: 10.1126/scitranslmed.aay7896  0.123
1986 Holtzman MJ, Grunberger D, Hunter JA. Phospholipid fatty acid composition of pulmonary airway epithelial cells: potential substrates for oxygenation. Biochimica Et Biophysica Acta. 877: 459-64. PMID 3089291 DOI: 10.1016/0005-2760(86)90212-2  0.123
1983 Holtzman MJ, Aizawa H, Nadel JA, Goetzl EJ. Selective generation of leukotriene B4 by tracheal epithelial cells from dogs Biochemical and Biophysical Research Communications. 114: 1071-1076. PMID 6311194 DOI: 10.1016/0006-291X(83)90671-X  0.122
2024 Kelly M, Dietz C, Kasson S, Zhang Y, Holtzman MJ, Kim IK. Deltex family E3 ligases specifically ubiquitinate the terminal ADP-ribose of poly(ADP-ribosyl)ation. Biochemical and Biophysical Research Communications. 720: 150101. PMID 38749191 DOI: 10.1016/j.bbrc.2024.150101  0.12
1982 Holtzman MJ, McNamara M, Sheppard D. Inhibition of bronchomotor responses to vagal stimulation and acetylcholine inhalation by atropine: Importance of route of administration Federation Proceedings. 41: 6349.  0.118
1998 Tsuchida T, Tanaka M, Okunaka T, Nakajima S, Nakajima R, Konaka C, Kato H, Azuma A, Kudoh S, Yamamoto M, Izumi T, Ando M, Abe S, Sugawara I, Takizawa H, ... ... Holtzman MJ, et al. General discussion on present the knowledge concerning small airways Journal of Tokyo Medical University. 56: 438-451.  0.115
2023 Sadegh C, Xu H, Sutin J, Fatou B, Gupta S, Pragana A, Taylor M, Kalugin PN, Zawadzki ME, Alturkistani O, Shipley FB, Dani N, Fame RM, Wurie Z, Talati P, ... ... Holtzman MJ, et al. Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus. Neuron. PMID 36893755 DOI: 10.1016/j.neuron.2023.02.020  0.109
2022 Parichha A, Suresh V, Chatterjee M, Kshirsagar A, Ben-Reuven L, Olender T, Taketo MM, Radosevic V, Bobic-Rasonja M, Trnski S, Holtzman MJ, Jovanov-Milosevic N, Reiner O, Tole S. Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. Nature Communications. 13: 633. PMID 35110543 DOI: 10.1038/s41467-021-27602-z  0.108
1981 Sheller JR, Holtzman MJ, Skoogh BE. Effect of serotonin on the airway smooth muscle response to vagal stimulation and to acetylcholine American Review of Respiratory Disease. 123: 198.  0.108
2024 Popli P, Oestreich AK, Maurya VK, Rowen MN, Masand R, Holtzman MJ, Zhang Y, Lydon J, Akira S, Moley KH, Kommagani R. The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy. Biorxiv : the Preprint Server For Biology. PMID 38562843 DOI: 10.1101/2024.03.19.585812  0.108
1990 Hansbrough JR, Takahashi Y, Ueda N, Yamamoto S, Holtzman MJ. Identification of a novel arachidonate 12-lipoxygenase in bovine tracheal epithelial cells distinct from leukocyte and platelet forms of the enzyme Journal of Biological Chemistry. 265: 1771-1776. PMID 2295656  0.106
1981 Holtzman MJ, Skoogh BE, Hahn H. Effect of general anesthetics on bronchomotor responses Physiologist. 24.  0.099
2014 Patel DA, Patel AC, Nolan WC, Huang G, Romero AG, Charlton N, Agapov E, Zhang Y, Holtzman MJ. High-throughput screening normalized to biological response: application to antiviral drug discovery. Journal of Biomolecular Screening. 19: 119-30. PMID 23860224 DOI: 10.1177/1087057113496848  0.098
2023 Uner AA, Yang WM, Kang MC, Rodrigues KCDC, Aydogan A, Seo JA, Mendes NF, Kim MS, Timzoura FE, Holtzman MJ, Lehtinen M, Prevot V, Kim YB. LRP1 mediates leptin transport by coupling with the short-form leptin receptor in the choroid plexus. Biorxiv : the Preprint Server For Biology. PMID 37461530 DOI: 10.1101/2023.07.03.547520  0.098
2013 Li A, Chan B, Felix JC, Xing Y, Li M, Brody SL, Zhang Y, Holtzman MJ, Borok Z, Li C, Minoo P. Correction: Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling (PLoS ONE) Plos One. 8. DOI: 10.1371/annotation/79fc47f5-11a5-4ef3-a80e-e2c5af62c5c1  0.098
1984 Walters EH, O'Byrne PM, Fabbri LM, Graf PD, Holtzman MJ, Nadel JA. Control of neurotransmission by prostaglandins in canine trachealis smooth muscle. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 57: 129-34. PMID 6088448  0.091
2022 Parichha A, Datta D, Suresh V, Chatterjee M, Holtzman MJ, Tole S. Dentate gyrus morphogenesis is regulated by β-CATENIN function in hem-derived fimbrial glia. Development (Cambridge, England). PMID 36196585 DOI: 10.1242/dev.200953  0.085
1979 Holtzman MJ, Cunningham JH, Sheller JR, Irsigler GB, Nadel JA, Boushey HA. Effect of ozone on bronchial reactivity in atopic and nonatopic subjects American Review of Respiratory Disease. 120: 1059-1067. PMID 507522  0.085
1985 Lazarus SC, Gold WM, Goetzl EJ, Holtzman MJ. 15-, 12-, and 5-lipoxygenase products of arachidonic acid differ between two canine mastocytoma cell lines Federation Proceedings. 44.  0.084
2021 Xu H, Fame RM, Sadegh C, Sutin J, Naranjo C, Della Syau, Cui J, Shipley FB, Vernon A, Gao F, Zhang Y, Holtzman MJ, Heiman M, Warf BC, Lin PY, et al. Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development. Nature Communications. 12: 447. PMID 33469018 DOI: 10.1038/s41467-020-20666-3  0.084
2023 Fame RM, Kalugin PN, Petrova B, Xu H, Soden PA, Shipley FB, Dani N, Grant B, Pragana A, Head JP, Gupta S, Shannon ML, Chifamba FF, Hawks-Mayer H, Vernon A, ... ... Holtzman MJ, et al. Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution. Nature Communications. 14: 3720. PMID 37349305 DOI: 10.1038/s41467-023-39326-3  0.083
1983 Skoogh BE, Nadel JA, Fabbri LM, Sheppard D, Holtzman MJ. Antihistaminic versus anticholinergic effects of atropine on canine trachealis muscle American Review of Respiratory Disease. 128: 603-606. PMID 6137986 DOI: 10.1164/Arrd.1983.128.4.603  0.081
1998 Sampaih DD, Roswit WT, Koga T, Waller MJ, Look PC, Castro M, Holtzman MJ. Autoamplification of stat 1-dependent gene expression Faseb Journal. 12.  0.077
1982 Holtzman MJ, Hahn HL, Sasaki K, Skoogh BE, Graf PD, Fabbri LM, Nadel JA. Selective effect of general anesthetics on reflex bronchoconstrictor responses in dogs. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 53: 126-33. PMID 7118625  0.077
2000 Jayaraman S, Bragdon MJ, Holtzman MJ, Ruiz P. THE ROLE OF CASPASES IN FAS-MEDIATED APOPTOSIS OF ALLOGENEIC ANTIGEN-REACTIVE T LYMPHOCYTES. Transplantation. 69: S186. DOI: 10.1097/00007890-200004271-00280  0.073
2002 Iregui M, Malen J, Tuteur P, Lynch J, Holtzman MJ, Kollef MH. Determinants of outcome for patients admitted to a long-term ventilator unit. Southern Medical Journal. 95: 310-7. PMID 11902697  0.066
2020 de Melo-Martín I, Holtzman M, Hacker KS. "I Want to Do It, But I Want to Make Sure That I Do It Right." Views of Patients with Parkinson's Disease Regarding Early Stem Cell Clinical Trial Participation. Ajob Empirical Bioethics. 11: 160-171. PMID 32516056 DOI: 10.1080/23294515.2020.1775721  0.056
1981 Skoogh BE, Holtzman MJ, Sheller JR, Nadel JA. Differential effect of pentobarbital on the response to parasympathetic ganglion stimulation vs. electrical field stimulation in ferret tracheal rings American Review of Respiratory Disease. 123: 202.  0.053
1989 Divita EL, Holtzman MJ, Mills RE, Walsh DT. Methodology for testing ir detectors in simulated nuclear radiation environments Proceedings of Spie - the International Society For Optical Engineering. 1108: 274-289. DOI: 10.1117/12.960702  0.037
1993 Cunningham TJ, Mazed MA, Holtzman MJ, Fossum ER, Cook WR, Cummings AC, Mewaldt RA. Cosmic-ray detector with interdigitated-finger pixels for two-dimensional position information from a single wafer side Proceedings of Spie - the International Society For Optical Engineering. 1948: 15-22.  0.034
2008 Cho SW, Marsh JW, Geller DA, Holtzman M, Zeh H, Bartlett DL, Gamblin TC. Surgical management of leiomyosarcoma of the inferior vena cava Journal of Gastrointestinal Surgery. 12: 2141-2148. PMID 18841423 DOI: 10.1007/s11605-008-0700-y  0.016
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