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David D. Mowrey, Ph.D. - Publications

Affiliations: 
2014 Computational and Systems Biology University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Biochemistry, General Biophysics, Neuroscience Biology
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sapienza PJ, Popov K, Mowrey DD, Falk BT, Dokholyan NV, Lee AL. Inter-Active Site Communication Mediated by the Dimer Interface Beta-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase. Biochemistry. PMID 31283187 DOI: 10.1021/Acs.Biochem.9B00486  0.407
2018 Li B, Tunc-Ozdemir M, Urano D, Jia H, Werth EG, Mowrey DD, Hicks LM, Dokholyan NV, Torres MP, Jones AM. Tyrosine phosphorylation switching of a G protein substrate. The Journal of Biological Chemistry. PMID 29382719 DOI: 10.1074/Jbc.Ra117.000163  0.359
2017 Xu L, Mowrey DD, Chirasani VR, Wang Y, Pasek DA, Dokholyan NV, Meissner G. G4941K substitution in the pore-lining S6 helix of the skeletal muscle ryanodine receptor increases RyR1 sensitivity to cytosolic and luminal Ca2. The Journal of Biological Chemistry. PMID 29255089 DOI: 10.1074/Jbc.M117.803247  0.386
2017 Mowrey DD, Xu L, Mei Y, Pasek DA, Meissner G, Dokholyan NV. Ion-pulling simulations provide insights into the mechanisms of channel opening of the skeletal muscle ryanodine receptor. The Journal of Biological Chemistry. PMID 28584051 DOI: 10.1074/Jbc.M116.760199  0.478
2015 Zhou DW, Mowrey DD, Tang P, Xu Y. Percolation Model of Sensory Transmission and Loss of Consciousness Under General Anesthesia. Physical Review Letters. 115: 108103. PMID 26382705 DOI: 10.1103/Physrevlett.115.108103  0.49
2015 Mei Y, Xu L, Mowrey DD, Mendez Giraldez R, Wang Y, Pasek DA, Dokholyan NV, Meissner G. Channel Gating Dependence on Pore Lining Helix Glycine Residues in Skeletal Muscle Ryanodine Receptor. The Journal of Biological Chemistry. 290: 17535-45. PMID 25998124 DOI: 10.1074/Jbc.M115.659672  0.404
2015 Kinde MN, Chen Q, Lawless MJ, Mowrey DD, Xu J, Saxena S, Xu Y, Tang P. Conformational Changes Underlying Desensitization of the Pentameric Ligand-Gated Ion Channel ELIC. Structure (London, England : 1993). 23: 995-1004. PMID 25960405 DOI: 10.1016/J.Str.2015.03.017  0.75
2015 Wells MM, Tillman TS, Mowrey DD, Sun T, Xu Y, Tang P. Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain. Journal of Medicinal Chemistry. 58: 2958-66. PMID 25790278 DOI: 10.1021/Jm501873P  0.613
2015 Mowrey DD, Kinde MN, Xu Y, Tang P. Atomistic insights into human Cys-loop receptors by solution NMR. Biochimica Et Biophysica Acta. 1848: 307-14. PMID 24680782 DOI: 10.1016/J.Bbamem.2014.03.014  0.758
2015 Kinde MN, Bu W, Seyoum E, Chen Q, Wells MM, Mowrey DD, Eckenhoff RG, Xu Y, Tang P. A Shared Binding Site for Propofol and Thiopental in ELIC Biophysical Journal. 108: 55a. DOI: 10.1016/J.Bpj.2014.11.332  0.742
2015 Wells MM, Mowrey DD, Seyoum E, Sun T, Xu Y, Tang P. Positive Modulators of Glycine Receptors with Analgesic Potential Identified by Virtual Screening Biophysical Journal. 108: 357a. DOI: 10.1016/J.Bpj.2014.11.1955  0.611
2014 Tillman TS, Seyoum E, Mowrey DD, Xu Y, Tang P. ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation. The Journal of Biological Chemistry. 289: 13851-7. PMID 24695730 DOI: 10.1074/Jbc.M113.524611  0.635
2014 Bondarenko V, Mowrey DD, Tillman TS, Seyoum E, Xu Y, Tang P. NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites. Biochimica Et Biophysica Acta. 1838: 1389-95. PMID 24384062 DOI: 10.1016/J.Bbamem.2013.12.018  0.691
2014 Mowrey DD, Liu Q, Bondarenko V, Chen Q, Seyoum E, Xu Y, Wu J, Tang P. Insights into the Distinctly Different Sensitivities of α7 and α7β2 nAChRs to the Volatile Anesthetic Isoflurane Biophysical Journal. 106: 341a. DOI: 10.1016/J.Bpj.2013.11.1952  0.646
2013 Mowrey DD, Liu Q, Bondarenko V, Chen Q, Seyoum E, Xu Y, Wu J, Tang P. Insights into distinct modulation of α7 and α7β2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane. The Journal of Biological Chemistry. 288: 35793-800. PMID 24194515 DOI: 10.1074/Jbc.M113.508333  0.667
2013 Mowrey DD, Cui T, Jia Y, Ma D, Makhov AM, Zhang P, Tang P, Xu Y. Open-channel structures of the human glycine receptor α1 full-length transmembrane domain. Structure (London, England : 1993). 21: 1897-904. PMID 23994010 DOI: 10.1016/J.Str.2013.07.014  0.695
2013 Mowrey D, Chen Q, Liang Y, Liang J, Xu Y, Tang P. Signal transduction pathways in the pentameric ligand-gated ion channels. Plos One. 8: e64326. PMID 23667707 DOI: 10.1371/Journal.Pone.0064326  0.676
2013 Mowrey D, Cheng MH, Liu LT, Willenbring D, Lu X, Wymore T, Xu Y, Tang P. Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels. Journal of the American Chemical Society. 135: 2172-80. PMID 23339564 DOI: 10.1021/Ja307275V  0.698
2013 Bondarenko V, Mowrey D, Liu LT, Xu Y, Tang P. NMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChR. Biochimica Et Biophysica Acta. 1828: 398-404. PMID 23000369 DOI: 10.1016/J.Bbamem.2012.09.014  0.707
2013 Mowrey DD, Chen Q, Xu Y, Tang P. Mechanisms of Channel Activation in GLIC Biophysical Journal. 104: 67a. DOI: 10.1016/J.Bpj.2012.11.405  0.619
2013 Bondarenko V, Mowrey D, Xu Y, Tang P. Anesthetic Binding Sites within the Transmembrane Domain of the α7 Nicotinic Acetylcholine Receptor Biophysical Journal. 104: 635a. DOI: 10.1016/J.Bpj.2012.11.3509  0.67
2013 Mowrey DD, Cheng MH, Liu LT, Willenbring D, Lu X, Wymore T, Xu Y, Tang P. Does Symmetry of Ligand Occupancy Matter to Conformational Transitions of Pentameric Ligand Gated Ion Channels? Biophysical Journal. 104: 380a. DOI: 10.1016/J.Bpj.2012.11.2116  0.69
2013 Bondarenko V, Mowrey D, Xu Y, Tang P. Structures of α7 and α4β2 nAChR transmenbrane domains and associated binding sites for allosteric modulators Biochemical Pharmacology. 86: 1227. DOI: 10.1016/J.Bcp.2013.08.036  0.647
2012 Pan J, Chen Q, Willenbring D, Mowrey D, Kong XP, Cohen A, Divito CB, Xu Y, Tang P. Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine. Structure (London, England : 1993). 20: 1463-9. PMID 22958642 DOI: 10.1016/J.Str.2012.08.009  0.701
2012 Bondarenko V, Mowrey D, Tillman T, Cui T, Liu LT, Xu Y, Tang P. NMR structures of the transmembrane domains of the α4β2 nAChR. Biochimica Et Biophysica Acta. 1818: 1261-8. PMID 22361591 DOI: 10.1016/J.Bbamem.2012.02.008  0.643
2012 Cui T, Mowrey D, Bondarenko V, Tillman T, Ma D, Landrum E, Perez-Aguilar JM, He J, Wang W, Saven JG, Eckenhoff RG, Tang P, Xu Y. NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor. Biochimica Et Biophysica Acta. 1818: 617-26. PMID 22155685 DOI: 10.1016/J.Bbamem.2011.11.021  0.659
2012 Xu Y, Mowrey D, Cui T, Perez-Aguilar J, Saven J, Eckenhoff R, Tang P. WSA major conformation Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lkg/Pdb  0.553
2012 Xu Y, Mowrey D, Cui T, Perez-Aguilar J, Saven J, Eckenhoff R, Tang P. WSA minor conformation Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr17992  0.551
2011 Willenbring D, Liu LT, Mowrey D, Xu Y, Tang P. Isoflurane alters the structure and dynamics of GLIC. Biophysical Journal. 101: 1905-12. PMID 22004744 DOI: 10.1016/J.Bpj.2011.09.026  0.704
2011 Chen Q, Mowrey D, Tao F, Johns R, Tang P. NMR Investigation of Volatile Anesthetics Interaction with PDZ Domains of PSD-95 Biophysical Journal. 100: 53a. DOI: 10.1016/J.Bpj.2010.12.488  0.606
2011 Mowrey DD, Lu H, Tang P. Allosteric Signaling of Anesthetic Isoflurane Bound to LFA-1 Revealed by the PMT Model Biophysical Journal. 100: 53a. DOI: 10.1016/J.Bpj.2010.12.487  0.618
2011 Liu LT, Li M, Mowrey D, Lu H, Liang J, Xu Y, Tang P. Anesthetic Modulation of Signal Transduction Pathways in the α4β2 nAchR Revealed by the Perturbation-Based Markovian Transmission Model Biophysical Journal. 100: 548a. DOI: 10.1016/J.Bpj.2010.12.3193  0.685
2010 Mowrey D, Haddadian EJ, Liu LT, Willenbring D, Xu Y, Tang P. Unresponsive correlated motion in alpha7 nAChR to halothane binding explains its functional insensitivity to volatile anesthetics. The Journal of Physical Chemistry. B. 114: 7649-55. PMID 20465243 DOI: 10.1021/Jp1009675  0.601
2010 Mowrey DD, Liu LT, Willenbring D, Haddadian EJ, Xu Y, Tang P. Why Is α4β2 Nachr More Sensitive to Volatile Anesthetics Than α7 Nachr? Biophysical Journal. 98: 38a. DOI: 10.1016/J.Bpj.2009.12.218  0.679
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