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Andrew J. Mitchell - Publications

Affiliations: 
2017-2019 Whitehead Institute for Biomedical Research, Cambridge, MA, United States 
 2019-2023 Ginkgo Bioworks 
 2023- Moderna 
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15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kim CY, Mitchell AJ, Kastner DW, Albright CE, Gutierrez MA, Glinkerman CM, Kulik HJ, Weng JK. Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY. Nature Communications. 14: 597. PMID 36737607 DOI: 10.1038/s41467-023-36299-1  0.696
2020 Kim CY, Mitchell AJ, Glinkerman CM, Li FS, Pluskal T, Weng JK. The chloroalkaloid (-)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants. Nature Communications. 11: 1867. PMID 32313070 DOI: 10.1038/S41467-020-15777-W  0.652
2019 Zhang B, Rajakovich LJ, Van Cura D, Blaesi EJ, Mitchell AJ, Tysoe CR, Zhu X, Streit BR, Rui Z, Zhang W, Boal AK, Krebs C, Bollinger JM. Substrate-triggered Formation of a Peroxo-Fe(III/III) Intermediate during Fatty Acid Decarboxylation by UndA. Journal of the American Chemical Society. PMID 31487162 DOI: 10.1021/Jacs.9B06093  0.64
2019 Levsh O, Pluskal T, Carballo V, Mitchell AJ, Weng JK. Independent evolution of rosmarinic acid biosynthesis in two sister families under the Lamiids clade of flowering plants. The Journal of Biological Chemistry. PMID 31481469 DOI: 10.1074/Jbc.Ra119.010454  0.72
2019 Christ B, Xu C, Xu M, Li FS, Wada N, Mitchell AJ, Han XL, Wen ML, Fujita M, Weng JK. Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants. Nature Communications. 10: 3206. PMID 31324795 DOI: 10.1038/S41467-019-11286-7  0.741
2019 Rajakovich L, Pandelia ME, Mitchell AJ, Chang WC, Zhang B, Boal AK, Krebs C, Bollinger JM. A new microbial pathway for organophosphonate degradation catalyzed by two previously misannotated non-heme-iron oxygenases. Biochemistry. PMID 30789718 DOI: 10.1021/acs.biochem.9b00044  0.658
2019 Ng TL, Rohac R, Mitchell AJ, Boal AK, Balskus EP. An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin. Nature. 566: 94-99. PMID 30728519 DOI: 10.1038/S41586-019-0894-Z  0.636
2019 Mitchell AJ, Weng JK. Unleashing the synthetic power of plant oxygenases: from mechanism to application. Plant Physiology. PMID 30670605 DOI: 10.1104/Pp.18.01223  0.672
2018 Dunham NP, Mitchell AJ, Del Río Pantoja JM, Krebs C, Bollinger JM, Boal AK. α-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC. Biochemistry. PMID 30403469 DOI: 10.1021/Acs.Biochem.8B00901  0.652
2018 Ban Z, Qin H, Mitchell AJ, Liu B, Zhang F, Weng JK, Dixon RA, Wang G. Noncatalytic chalcone isomerase-fold proteins in are auxiliary components in prenylated flavonoid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29760092 DOI: 10.1073/Pnas.1802223115  0.59
2018 Dunham NP, Chang WC, Mitchell AJ, Martinie RJ, Zhang B, Bergman JA, Rajakovich LJ, Wang B, Silakov A, Krebs C, Boal AK, Bollinger JM. Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance. Journal of the American Chemical Society. PMID 29708749 DOI: 10.1021/Jacs.8B01933  0.634
2017 Mitchell AJ, Dunham NP, Martinie RJ, Bergman JA, Pollock CJ, Hu K, Allen BD, Chang WC, Silakov A, Bollinger JM, Krebs C, Boal AK. Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase. Journal of the American Chemical Society. 139: 13830-13836. PMID 28823155 DOI: 10.1021/Jacs.7B07374  0.633
2016 Mitchell AJ, Dunham NP, Bergman JA, Wang B, Zhu Q, Chang WC, Liu X, Boal AK. Structure-guided reprogramming of a hydroxylase to halogenate its small molecule substrate. Biochemistry. PMID 28029241 DOI: 10.1021/Acs.Biochem.6B01173  0.64
2016 Mitchell AJ, Zhu Q, Maggiolo AO, Ananth NR, Hillwig ML, Liu X, Boal AK. Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5. Nature Chemical Biology. PMID 27348090 DOI: 10.1038/Nchembio.2112  0.612
2016 Mitchell AJ. The Botany of Romanticism: Plants and the Exposition of Life Comparative and Continental Philosophy. 8: 315-328. DOI: 10.1080/17570638.2016.1231883  0.38
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