| Year |
Citation |
Score |
| 2016 |
Houck JD, Dawson TK, Kennedy AJ, Kharel Y, Naimon ND, Field SD, Lynch KR, Macdonald TL. Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles. Acs Medicinal Chemistry Letters. 7: 487-92. PMID 27190598 DOI: 10.1021/Acsmedchemlett.6B00002 |
0.793 |
|
| 2016 |
Kennedy AJ, Bruce AM, Gineste C, Ballard TE, Olekhnovich IN, Macdonald TL, Hoffman PS. Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate: Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilon Proteobacteria. Antimicrobial Agents and Chemotherapy. PMID 27090174 DOI: 10.1128/Aac.00670-16 |
0.646 |
|
| 2012 |
East JE, Macdonald TL. Cost-effective and Large-scale synthesis of 16:0 Lysophosphatidic Acid. Synthetic Communications. 42: 3614-3618. PMID 23264701 DOI: 10.1080/00397911.2011.587080 |
0.542 |
|
| 2012 |
Warren CA, van Opstal E, Ballard TE, Kennedy A, Wang X, Riggins M, Olekhnovich I, Warthan M, Kolling GL, Guerrant RL, Macdonald TL, Hoffman PS. Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model. Antimicrobial Agents and Chemotherapy. 56: 4103-11. PMID 22585229 DOI: 10.1128/Aac.00360-12 |
0.6 |
|
| 2012 |
East JE, MacDonald TL. Cost-effective and large-scale synthesis of 16:0 lysophosphatidic acid Synthetic Communications. 42: 3614-3619. DOI: 10.1080/00397911.2011.587080 |
0.438 |
|
| 2011 |
East JE, Carter KM, Kennedy PC, Schulte NA, Toews ML, Lynch KR, Macdonald TL. Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. Medchemcomm. 2: 325-330. PMID 22180836 DOI: 10.1039/C0Md00273A |
0.58 |
|
| 2011 |
Kharel Y, Mathews TP, Gellett AM, Tomsig JL, Kennedy PC, Moyer ML, Macdonald TL, Lynch KR. Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. The Biochemical Journal. 440: 345-53. PMID 21848514 DOI: 10.1042/Bj20110817 |
0.689 |
|
| 2011 |
Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. The Journal of Pharmacology and Experimental Therapeutics. 338: 879-89. PMID 21632869 DOI: 10.1124/Jpet.111.181552 |
0.755 |
|
| 2011 |
Kennedy AJ, Mathews TP, Kharel Y, Field SD, Moyer ML, East JE, Houck JD, Lynch KR, Macdonald TL. Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. Journal of Medicinal Chemistry. 54: 3524-48. PMID 21495716 DOI: 10.1021/Jm2001053 |
0.786 |
|
| 2011 |
Ballard TE, Wang X, Olekhnovich I, Koerner T, Seymour C, Salamoun J, Warthan M, Hoffman PS, Macdonald TL. Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: identification of selective and broad spectrum activity. Chemmedchem. 6: 362-77. PMID 21275058 DOI: 10.1002/Cmdc.201000475 |
0.365 |
|
| 2011 |
Kharel Y, Mathews TP, Kennedy AJ, Houck JD, Macdonald TL, Lynch KR. A rapid assay for assessment of sphingosine kinase inhibitors and substrates. Analytical Biochemistry. 411: 230-5. PMID 21216217 DOI: 10.1016/J.Ab.2011.01.003 |
0.779 |
|
| 2011 |
Sefcik LS, Aronin CE, Awojoodu AO, Shin SJ, Mac Gabhann F, MacDonald TL, Wamhoff BR, Lynch KR, Peirce SM, Botchwey EA. Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth. Tissue Engineering. Part A. 17: 617-29. PMID 20874260 DOI: 10.1089/Ten.Tea.2010.0404 |
0.312 |
|
| 2010 |
East JE, Kennedy AJ, Tomsig JL, De Leon AR, Lynch KR, Macdonald TL. Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX). Bioorganic & Medicinal Chemistry Letters. 20: 7132-6. PMID 20951039 DOI: 10.1016/J.Bmcl.2010.09.030 |
0.713 |
|
| 2010 |
Yang M, Chordia MD, Li F, Huang T, Linden J, MacDonald TL. Neutrophil- and myeloperoxidase-mediated metabolism of reduced nimesulide: Evidence for bioactivation Chemical Research in Toxicology. 23: 1691-1700. PMID 20939553 DOI: 10.1021/Tx1001496 |
0.709 |
|
| 2010 |
Ballard TE, Wang X, Olekhnovich I, Koerner T, Seymour C, Hoffman PS, Macdonald TL. Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide. Bioorganic & Medicinal Chemistry Letters. 20: 3537-9. PMID 20488706 DOI: 10.1016/J.Bmcl.2010.04.126 |
0.332 |
|
| 2010 |
Mathews TP, Kennedy AJ, Kharel Y, Kennedy PC, Nicoara O, Sunkara M, Morris AJ, Wamhoff BR, Lynch KR, Macdonald TL. Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. Journal of Medicinal Chemistry. 53: 2766-78. PMID 20205392 DOI: 10.1021/Jm901860H |
0.764 |
|
| 2010 |
Ma B, Guckian KM, Lin EY, Lee WC, Scott D, Kumaravel G, Macdonald TL, Lynch KR, Black C, Chollate S, Hahm K, Hetu G, Jin P, Luo Y, Rohde E, et al. Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. Bioorganic & Medicinal Chemistry Letters. 20: 2264-9. PMID 20188554 DOI: 10.1016/J.Bmcl.2010.02.006 |
0.371 |
|
| 2009 |
Cross JV, Rady JM, Foss FW, Lyons CE, Macdonald TL, Templeton DJ. Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF) Biochemical Journal. 423: 315-321. PMID 19723024 DOI: 10.1042/Bj20091170 |
0.681 |
|
| 2009 |
Foss FW, Mathews TP, Kharel Y, Kennedy PC, Snyder AH, Davis MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorganic & Medicinal Chemistry. 17: 6123-36. PMID 19632123 DOI: 10.1016/J.Bmc.2009.04.015 |
0.803 |
|
| 2009 |
Sim-Selley LJ, Goforth PB, Mba MU, Macdonald TL, Lynch KR, Milstien S, Spiegel S, Satin LS, Welch SP, Selley DE. Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. Journal of Neurochemistry. 110: 1191-202. PMID 19493165 DOI: 10.1111/J.1471-4159.2009.06202.X |
0.341 |
|
| 2009 |
Joshi EM, Heasley BH, MacDonald TL. 2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileuton Xenobiotica. 39: 197-204. PMID 19280518 DOI: 10.1080/00498250802651976 |
0.785 |
|
| 2009 |
Gaetano CG, Samadi N, Tomsig JL, Macdonald TL, Lynch KR, Brindley DN. Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells. Molecular Carcinogenesis. 48: 801-9. PMID 19204929 DOI: 10.1002/Mc.20524 |
0.314 |
|
| 2009 |
Li F, Chordia MD, Huang T, Macdonald TL. In vitro nimesulide studies toward understanding idiosyncratic hepatotoxicity: Diiminoquinone formation and conjugation Chemical Research in Toxicology. 22: 72-80. PMID 19053182 DOI: 10.1021/Tx800152R |
0.684 |
|
| 2008 |
Wamhoff BR, Lynch KR, Macdonald TL, Owens GK. Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1454-61. PMID 18535287 DOI: 10.1161/Atvbaha.107.159392 |
0.327 |
|
| 2008 |
Deveau AM, Costa NE, Joshi EM, Macdonald TL. Synthesis of diketopiperazine-based carboline homodimers and in vitro growth inhibition of human carcinomas Bioorganic and Medicinal Chemistry Letters. 18: 3522-3525. PMID 18502124 DOI: 10.1016/J.Bmcl.2008.05.022 |
0.794 |
|
| 2008 |
Jain HD, Zhang C, Zhou S, Zhou H, Ma J, Liu X, Liao X, Deveau AM, Dieckhaus CM, Johnson MA, Smith KS, Macdonald TL, Kakeya H, Osada H, Cook JM. Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorganic & Medicinal Chemistry. 16: 4626-51. PMID 18321710 DOI: 10.1016/J.Bmc.2008.02.050 |
0.787 |
|
| 2008 |
Sun Q, Zhu R, Foss FW, Macdonald TL. In vitro metabolism of a model cyclopropylamine to reactive intermediate: Insights into trovafloxacin-induced hepatotoxicity Chemical Research in Toxicology. 21: 711-719. PMID 18298092 DOI: 10.1021/Tx7003085 |
0.786 |
|
| 2008 |
Cui P, McCalmont WF, Tomsig JL, Lynch KR, Macdonald TL. alpha- and beta-substituted phosphonate analogs of LPA as autotaxin inhibitors. Bioorganic & Medicinal Chemistry. 16: 2212-25. PMID 18082408 DOI: 10.1016/J.Bmc.2007.11.078 |
0.781 |
|
| 2007 |
Zhu R, Snyder AH, Kharel Y, Schaffter L, Sun Q, Kennedy PC, Lynch KR, Macdonald TL. Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. Journal of Medicinal Chemistry. 50: 6428-35. PMID 17994678 DOI: 10.1021/Jm7010172 |
0.671 |
|
| 2007 |
Sun Q, Zhu R, Foss FW, Macdonald TL. Mechanisms of trovafloxacin hepatotoxicity: Studies of a model cyclopropylamine-containing system Bioorganic and Medicinal Chemistry Letters. 17: 6682-6686. PMID 17976985 DOI: 10.1016/J.Bmcl.2007.10.070 |
0.765 |
|
| 2007 |
Li F, Chordia MD, Woodling KA, Macdonald TL. Irreversible alkylation of human serum albumin by zileuton metabolite 2-acetylbenzothiophene-S-oxide: A potential model for hepatotoxicity Chemical Research in Toxicology. 20: 1854-1861. PMID 17944539 DOI: 10.1021/Tx7001417 |
0.663 |
|
| 2007 |
Cross JV, Foss FW, Rady JM, Macdonald TL, Templeton DJ. The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase Bmc Cancer. 7. PMID 17894894 DOI: 10.1186/1471-2407-7-183 |
0.71 |
|
| 2007 |
Palmer LA, Doctor A, Chhabra P, Sheram ML, Laubach VE, Karlinsey MZ, Forbes MS, Macdonald T, Gaston B. S-nitrosothiols signal hypoxia-mimetic vascular pathology. The Journal of Clinical Investigation. 117: 2592-601. PMID 17786245 DOI: 10.1172/Jci29444 |
0.763 |
|
| 2007 |
Glover DK, Ruiz M, Takehana K, Petruzella FD, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA. Cardioprotection by adenosine A2A agonists in a canine model of myocardial stunning produced by multiple episodes of transient ischemia. American Journal of Physiology. Heart and Circulatory Physiology. 292: H3164-71. PMID 17308004 DOI: 10.1152/Ajpheart.00743.2005 |
0.636 |
|
| 2007 |
Cui P, Tomsig JL, McCalmont WF, Lee S, Becker CJ, Lynch KR, Macdonald TL. Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 1634-40. PMID 17257836 DOI: 10.1016/J.Bmcl.2006.12.114 |
0.798 |
|
| 2007 |
Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. The Journal of Biological Chemistry. 282: 9082-9. PMID 17237497 DOI: 10.1074/Jbc.M610318200 |
0.355 |
|
| 2007 |
Foss FW, Snyder AH, Davis MD, Rouse M, Okusa MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorganic & Medicinal Chemistry. 15: 663-77. PMID 17113298 DOI: 10.1016/J.Bmc.2006.10.060 |
0.716 |
|
| 2006 |
Cui P, Macdonald TL, Chen M, Nadler JL. Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes Bioorganic and Medicinal Chemistry Letters. 16: 3401-3405. PMID 16650991 DOI: 10.1016/J.Bmcl.2006.04.036 |
0.475 |
|
| 2006 |
Zhu R, Frazier CR, Linden J, Macdonald TL. N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists. Bioorganic & Medicinal Chemistry Letters. 16: 2416-8. PMID 16487705 DOI: 10.1016/J.Bmcl.2006.01.110 |
0.52 |
|
| 2006 |
Schonhoff CM, Matsuoka M, Tummala H, Johnson MA, Estevéz AG, Wu R, Kamaid A, Ricart KC, Hashimoto Y, Gaston B, Macdonald TL, Xu Z, Mannick JB. S-nitrosothiol depletion in amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 103: 2404-9. PMID 16461917 DOI: 10.1073/Pnas.0507243103 |
0.457 |
|
| 2006 |
Awad AS, Ye H, Huang L, Li L, Foss FW, Macdonald TL, Lynch KR, Okusa MD. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. American Journal of Physiology. Renal Physiology. 290: F1516-24. PMID 16403835 DOI: 10.1152/Ajprenal.00311.2005 |
0.694 |
|
| 2005 |
Foss FW, Clemens JJ, Davis MD, Snyder AH, Zigler MA, Lynch KR, Macdonald TL. Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. Bioorganic & Medicinal Chemistry Letters. 15: 4470-4. PMID 16125386 DOI: 10.1016/J.Bmcl.2005.07.057 |
0.795 |
|
| 2005 |
Kharel Y, Lee S, Snyder AH, Sheasley-O'neill SL, Morris MA, Setiady Y, Zhu R, Zigler MA, Burcin TL, Ley K, Tung KS, Engelhard VH, Macdonald TL, Pearson-White S, Lynch KR. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. The Journal of Biological Chemistry. 280: 36865-72. PMID 16093248 DOI: 10.1074/Jbc.M506293200 |
0.497 |
|
| 2005 |
Chordia MD, Zigler M, Murphree LJ, Figler H, Macdonald TL, Olsson RA, Linden J. 6-Aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency Journal of Medicinal Chemistry. 48: 5131-5139. PMID 16078833 DOI: 10.1021/Jm049132J |
0.365 |
|
| 2005 |
Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 15: 3568-72. PMID 15982878 DOI: 10.1016/J.Bmcl.2005.05.097 |
0.729 |
|
| 2005 |
McCalmont WF, Patterson JR, Lindenmuth MA, Heady TN, Haverstick DM, Gray LS, Macdonald TL. Investigation into the structure-activity relationship of novel concentration dependent, dual action T-type calcium channel agonists/antagonists. Bioorganic & Medicinal Chemistry. 13: 3821-39. PMID 15863008 DOI: 10.1016/J.Bmc.2005.03.004 |
0.787 |
|
| 2005 |
Bolick DT, Srinivasan S, Kim KW, Hatley ME, Clemens JJ, Whetzel A, Ferger N, Macdonald TL, Davis MD, Tsao PS, Lynch KR, Hedrick CC. Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 976-81. PMID 15761190 DOI: 10.1161/01.Atv.0000162171.30089.F6 |
0.707 |
|
| 2005 |
Glover DK, Riou LM, Ruiz M, Sullivan GW, Linden J, Rieger JM, Macdonald TL, Watson DD, Beller GA. Reduction of infarct size and postischemic inflammation from ATL-146e, a highly selective adenosine A2A receptor agonist, in reperfused canine myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 288: H1851-8. PMID 15591104 DOI: 10.1152/Ajpheart.00362.2004 |
0.606 |
|
| 2005 |
Davis MD, Clemens JJ, Macdonald TL, Lynch KR. Sphingosine 1-phosphate analogs as receptor antagonists. The Journal of Biological Chemistry. 280: 9833-41. PMID 15590668 DOI: 10.1074/Jbc.M412356200 |
0.734 |
|
| 2005 |
Gray L, Perez-Reyes E, Gomora J, Haverstick D, Shattock M, McLatchie L, Harper J, Brooks G, Heady T, Macdonald T. Erratum to “The role of voltage gated T-type Ca2+ channel isoforms in mediating “capacitative” Ca2+ entry in cancer cells” [Cell Calcium 36 (2004) 489–497] Cell Calcium. 37: 603. DOI: 10.1016/J.Ceca.2004.11.002 |
0.762 |
|
| 2004 |
Gray LS, Perez-Reyes E, Gomora JC, Gamorra JC, Haverstick DM, Shattock M, McLatchie L, Harper J, Brooks G, Heady T, Macdonald TL. The role of voltage gated T-type Ca2+ channel isoforms in mediating "capacitative" Ca2+ entry in cancer cells. Cell Calcium. 36: 489-97. PMID 15488598 DOI: 10.1016/J.Ceca.2004.05.001 |
0.778 |
|
| 2004 |
Johnson MA, Macdonald TL. Accelerated CuZn-SOD-mediated oxidation and reduction in the presence of hydrogen peroxide. Biochemical and Biophysical Research Communications. 324: 446-50. PMID 15465039 DOI: 10.1016/J.Bbrc.2004.09.066 |
0.437 |
|
| 2004 |
Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 14: 4903-6. PMID 15341948 DOI: 10.1016/J.Bmcl.2004.07.030 |
0.739 |
|
| 2004 |
Heasley BH, Jarosz R, Carter KM, Van SJ, Lynch KR, Macdonald TL. A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist. Bioorganic & Medicinal Chemistry Letters. 14: 4069-74. PMID 15225728 DOI: 10.1016/J.Bmcl.2004.05.023 |
0.778 |
|
| 2004 |
McCalmont WF, Heady TN, Patterson JR, Lindenmuth MA, Haverstick DM, Gray LS, Macdonald TL. Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists. Bioorganic & Medicinal Chemistry Letters. 14: 3691-5. PMID 15203145 DOI: 10.1016/J.Bmcl.2004.05.011 |
0.787 |
|
| 2004 |
Santos WL, Heasley BH, Jarosz R, Carter KM, Lynch KR, Macdonald TL. Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorganic & Medicinal Chemistry Letters. 14: 3473-6. PMID 15177455 DOI: 10.1016/J.Bmcl.2004.04.061 |
0.795 |
|
| 2004 |
Heasley BH, Jarosz R, Lynch KR, Macdonald TL. Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist. Bioorganic & Medicinal Chemistry Letters. 14: 2735-40. PMID 15125924 DOI: 10.1016/J.Bmcl.2004.03.076 |
0.783 |
|
| 2004 |
Joshi E, Chordia MD, Macdonald TL, Linden J, Olsson R. Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO Bioorganic and Medicinal Chemistry Letters. 14: 929-933. PMID 15012996 DOI: 10.1016/J.Bmcl.2003.12.010 |
0.726 |
|
| 2004 |
Joshi EM, Heasley BH, Chordia MD, Macdonald TL. In Vitro Metabolism of 2-Acetylbenzothiophene: Relevance to Zileuton Hepatotoxicity Chemical Research in Toxicology. 17: 137-143. PMID 14967000 DOI: 10.1021/Tx0341409 |
0.792 |
|
| 2004 |
Deveau AM, Macdonald TL. Practical synthesis of biaryl colchicinoids containing 3′,4′- catechol ether-based A-rings via Suzuki cross-coupling with ligandless palladium in water Tetrahedron Letters. 45: 803-807. DOI: 10.1016/J.Tetlet.2003.11.016 |
0.77 |
|
| 2003 |
Haji-Momenian S, Rieger JM, Macdonald TL, Brown ML. Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6. Bioorganic & Medicinal Chemistry. 11: 5545-54. PMID 14642599 DOI: 10.1016/S0968-0896(03)00525-X |
0.625 |
|
| 2003 |
Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. Bioorganic & Medicinal Chemistry Letters. 13: 3401-4. PMID 14505636 DOI: 10.1016/S0960-894X(03)00812-6 |
0.739 |
|
| 2003 |
Smith KS, Smith PL, Heady TN, Trugman JM, Harman WD, Macdonald TL. In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity. Chemical Research in Toxicology. 16: 123-8. PMID 12588182 DOI: 10.1021/Tx025569N |
0.786 |
|
| 2002 |
Riou LM, Ruiz M, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA, Glover DK. Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A2A-receptor-mediated coronary vasodilation Journal of the American College of Cardiology. 40: 1687-1694. PMID 12427424 DOI: 10.1016/S0735-1097(02)02372-0 |
0.625 |
|
| 2002 |
Kapetanovic IM, Torchin CD, Strong JM, Yonekawa WD, Lu C, Li AP, Dieckhaus CM, Santos WL, Macdonald TL, Sofia RD, Kupferberg HJ. Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro Chemico-Biological Interactions. 142: 119-134. PMID 12399159 DOI: 10.1016/S0009-2797(02)00058-3 |
0.801 |
|
| 2002 |
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL. Mechanisms of idiosyncratic drug reactions: The case of felbamate Chemico-Biological Interactions. 142: 99-117. PMID 12399158 DOI: 10.1016/S0009-2797(02)00057-1 |
0.775 |
|
| 2002 |
Gozal D, Gaston BM, Lipton AJ, Johnson MA, Macdonald T, Lieberman MW. Physiology: The ventilatory response to hypoxia Nature. 419: 686. PMID 12384687 |
0.302 |
|
| 2002 |
Lynch KR, Macdonald TL. Structure-activity relationships of lysophosphatidic acid analogs. Biochimica Et Biophysica Acta. 1582: 289-94. PMID 12069840 DOI: 10.1016/S1388-1981(02)00183-X |
0.372 |
|
| 2002 |
Roller SG, Dieckhaus CM, Santos WL, Sofia RD, Macdonald TL. Interaction between human serum albumin and the felbamate metabolites 4-Hydroxy-5-phenyl-[1,3]oxazinan-2-one and 2-phenylpropenal. Chemical Research in Toxicology. 15: 815-24. PMID 12067249 DOI: 10.1021/Tx025509H |
0.789 |
|
| 2002 |
Chordia MD, Murphree LJ, Macdonald TL, Linden J, Olsson RA. 2-Aminothiazoles: A new class of agonist allosteric enhancers of A1 adenosine receptors Bioorganic and Medicinal Chemistry Letters. 12: 1563-1566. PMID 12039562 DOI: 10.1016/S0960-894X(02)00236-6 |
0.352 |
|
| 2002 |
Zhao S, Smith KS, Deveau AM, Dieckhaus CM, Johnson MA, Macdonald TL, Cook JM. Biological activity of the tryprostatins and their diastereomers on human carcinoma cell lines. Journal of Medicinal Chemistry. 45: 1559-62. PMID 11931609 DOI: 10.1021/Jm0155953 |
0.781 |
|
| 2002 |
Murphree LJ, Marshall MA, Rieger JM, MacDonald TL, Linden J. Human A2A adenosine receptors: High-affinity agonist binding to receptor-g protein complexes containing Gβ4 Molecular Pharmacology. 61: 455-462. PMID 11809871 DOI: 10.1124/Mol.61.2.455 |
0.654 |
|
| 2002 |
Gozal D, Gaston BM, Lipton AJ, Johnson MA, Macdonald T, Lieberman MW. The ventilatory response to hypoxia Nature. 419: 686-686. DOI: 10.1038/419686B |
0.382 |
|
| 2002 |
Roller SG, Dieckhaus CM, Santos WL, Sofia RD, Macdonald TL. Interaction between human serum albumin and the felbamate metabolites 4-hydroxy-5-phenyl-[1,3]oxazinan-2-one and 2-phenylpropenal Chemical Research in Toxicology. 15: 815-824. DOI: 10.1021/tx025509h |
0.761 |
|
| 2002 |
Riou LM, Ruiz M, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA, Glover DK. Verapamil attenuates the coronary vasodilatory response to adenosine and A 2A adenosine receptor agonists Journal of the American College of Cardiology. 39: 369. DOI: 10.1016/S0735-1097(02)81660-6 |
0.625 |
|
| 2001 |
Heise CE, Santos WL, Schreihofer AM, Heasley BH, Mukhin YV, Macdonald TL, Lynch KR. Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Molecular Pharmacology. 60: 1173-80. PMID 11723223 DOI: 10.1124/Mol.60.6.1173 |
0.798 |
|
| 2001 |
Im DS, Clemens J, Macdonald TL, Lynch KR. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 40: 14053-60. PMID 11705398 DOI: 10.1021/Bi011606I |
0.704 |
|
| 2001 |
Lipton AJ, Johnson MA, Macdonald T, Lieberman MW, Gozal D, Gaston B. S-nitrosothiols signal the ventilatory response to hypoxia. Nature. 413: 171-4. PMID 11557982 DOI: 10.1038/35093117 |
0.436 |
|
| 2001 |
Glover DK, Ruiz M, Takehana K, Petruzella FD, Riou LM, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA. Pharmacological stress myocardial perfusion imaging with the potent and selective A2A adenosine receptor agonists ATL193 and ATL146e administered by either intravenous infusion or bolus injection Circulation. 104: 1181-1187. PMID 11535577 DOI: 10.1161/Hc3601.093983 |
0.649 |
|
| 2001 |
Johnson MA, Macdonald TL, Mannick JB, Conaway MR, Gaston B. Accelerated s-nitrosothiol breakdown by amyotrophic lateral sclerosis mutant copper,zinc-superoxide dismutase. The Journal of Biological Chemistry. 276: 39872-8. PMID 11518706 DOI: 10.1074/jbc.M102781200 |
0.338 |
|
| 2001 |
Dieckhaus CM, Santos WL, Sofia RD, Macdonald TL. The chemistry, toxicology, and identification in rat and human urine of 4-hydroxy-5-phenyl-1,3-oxazaperhydroin-2-one: A reactive metabolite in felbamate bioactivation Chemical Research in Toxicology. 14: 958-964. PMID 11511169 DOI: 10.1021/Tx000139N |
0.798 |
|
| 2001 |
Peirce SM, Skalak TC, Rieger JM, Macdonald TL, Linden J. Selective A2A adenosine receptor activation reduces skin pressure ulcer formation and inflammation American Journal of Physiology - Heart and Circulatory Physiology. 281: H67-H74. PMID 11406470 DOI: 10.1152/Ajpheart.2001.281.1.H67 |
0.621 |
|
| 2001 |
Deveau AM, Labroli MA, Dieckhaus CM, Barthen MT, Smith KS, Macdonald TL. The synthesis of amino-acid functionalized beta-carbolines as topoisomerase II inhibitors. Bioorganic & Medicinal Chemistry Letters. 11: 1251-5. PMID 11392530 DOI: 10.1016/S0960-894X(01)00136-6 |
0.784 |
|
| 2001 |
Heady TN, Gomora JC, Macdonald TL, Perez-Reyes E. Molecular pharmacology of T-type Ca2+ channels. Japanese Journal of Pharmacology. 85: 339-50. PMID 11388636 DOI: 10.1254/Jjp.85.339 |
0.772 |
|
| 2001 |
Dieckhaus CM, Roller SG, Santos WL, Sofia RD, Macdonald TL. Role of glutathione S-transferases A1-1, M1-1, and P1-1 in the detoxification of 2-phenylpropenal, a reactive felbamate metabolite Chemical Research in Toxicology. 14: 511-516. PMID 11368548 DOI: 10.1021/Tx000141E |
0.785 |
|
| 2001 |
McPherson JA, Barringhaus KG, Bishop GG, Sanders JM, Rieger JM, Hesselbacher SE, Gimple LW, Powers ER, Macdonald T, Sullivan G, Linden J, Sarembock IJ. Adenosine A(2A) receptor stimulation reduces inflammation and neointimal growth in a murine carotid ligation model. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 791-6. PMID 11348876 DOI: 10.1161/01.Atv.21.5.791 |
0.605 |
|
| 2001 |
Sullivan GW, Rieger JM, Scheld WM, Macdonald TL, Linden J. Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists. British Journal of Pharmacology. 132: 1017-26. PMID 11226132 DOI: 10.1038/Sj.Bjp.0703893 |
0.679 |
|
| 2001 |
Rieger JM, Brown ML, Sullivan GW, Linden J, Macdonald TL. Design, synthesis, and evaluation of novel A2A adenosine receptor agonists Journal of Medicinal Chemistry. 44: 531-539. PMID 11170643 DOI: 10.1021/Jm0003642 |
0.657 |
|
| 2001 |
Hooks SB, Santos WL, Im DS, Heise CE, Macdonald TL, Lynch KR. Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. The Journal of Biological Chemistry. 276: 4611-21. PMID 11042183 DOI: 10.1074/Jbc.M007782200 |
0.607 |
|
| 2000 |
Okusa MD, Linden J, Huang L, Rieger JM, MacDonald TL, Huynh LP. A(2A) adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion American Journal of Physiology - Renal Physiology. 279: F809-F818. PMID 11053040 DOI: 10.1152/Ajprenal.2000.279.5.F809 |
0.628 |
|
| 2000 |
Miller TA, Ghosh J, Myers CE, Macdonald TL. 5-HETE congeners as modulators of cell proliferation. Bioorganic & Medicinal Chemistry Letters. 10: 1913-6. PMID 10987416 DOI: 10.1016/S0960-894X(00)00370-X |
0.339 |
|
| 2000 |
Brown ML, Rieger JM, Macdonald TL. Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on beta-tubulin. Bioorganic & Medicinal Chemistry. 8: 1433-41. PMID 10896120 DOI: 10.1016/S0968-0896(00)00068-7 |
0.63 |
|
| 2000 |
Dieckhaus CM, Miller TA, Sofia RD, Macdonald TL. A mechanistic approach to understanding species differences in felbamate bioactivation: relevance to drug-induced idiosyncratic reactions. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 814-22. PMID 10859156 |
0.756 |
|
| 2000 |
Santos WL, Rossi JA, Boggs SD, MacDonald TL. The molecular pharmacology of lysophosphatidate signaling. Annals of the New York Academy of Sciences. 905: 232-41. PMID 10818457 DOI: 10.1111/J.1749-6632.2000.Tb06553.X |
0.54 |
|
| 2000 |
Thompson CD, Miller TA, Barthen MT, Dieckhaus CM, Sofia RD, Macdonald TL. The synthesis, in vitro reactivity, and evidence for formation in humans of 5-phenyl-1,3-oxazinane-2,4-dione, a metabolite of felbamate. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 434-9. PMID 10725312 |
0.778 |
|
| 2000 |
Haverstick DM, Heady TN, Macdonald TL, Gray LS. Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry. Cancer Research. 60: 1002-8. PMID 10706116 |
0.786 |
|
| 2000 |
Miller TA, Dieckhaus CM, Macdonald TL. A facile, one-pot procedure for the preparation of 2-phenyl-1,3-propanediol monocarbamate, a metabolite of felbamate Organic Process Research and Development. 4: 611-612. DOI: 10.1021/Op990198B |
0.749 |
|
| 1999 |
Thompson CD, Barthen MT, Hopper DW, Miller TA, Quigg M, Hudspeth C, Montouris G, Marsh L, Perhach JL, Sofia RD, Macdonald TL. Quantification in patient urine samples of felbamate and three metabolites: acid carbamate and two mercapturic acids. Epilepsia. 40: 769-76. PMID 10368077 DOI: 10.1111/J.1528-1157.1999.Tb00777.X |
0.337 |
|
| 1999 |
Miller TA, Bulman AL, Thompson CD, Macdonald TL. The synthesis and evaluation of temperature sensitive tubulin toxins. Bioorganic & Medicinal Chemistry Letters. 9: 407-12. PMID 10091693 DOI: 10.1016/S0960-894X(98)00747-1 |
0.35 |
|
| 1999 |
Hopper DW, Ragan SP, Hooks SB, Lynch KR, Macdonald TL. Structure--activity relationships of lysophosphatidic acid: conformationally restricted backbone mimetics. Journal of Medicinal Chemistry. 42: 963-70. PMID 10090779 DOI: 10.1021/Jm970809V |
0.392 |
|
| 1998 |
Miller TA, Vachaspati PR, Labroli MA, Thompson CD, Bulman AL, Macdonald TL. The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins. Bioorganic & Medicinal Chemistry Letters. 8: 1065-70. PMID 9871709 DOI: 10.1016/S0960-894X(98)00176-0 |
0.785 |
|
| 1998 |
Hooks SB, Ragan SP, Hopper DW, Hönemann CW, Durieux ME, Macdonald TL, Lynch KR. Characterization of a receptor subtype-selective lysophosphatidic acid mimetic. Molecular Pharmacology. 53: 188-94. PMID 9463475 DOI: 10.1124/Mol.53.2.188 |
0.359 |
|
| 1997 |
Miller TA, Bulman AL, Thompson CD, Garst ME, Macdonald TL. Synthesis and structure-activity profiles of A-homoestranes, the estratropones. Journal of Medicinal Chemistry. 40: 3836-41. PMID 9371249 DOI: 10.1021/Jm970323E |
0.361 |
|
| 1997 |
Madalengoitia JS, Tepe JJ, Werbovetz KA, Lehnert EK, Macdonald TL. Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues. Bioorganic & Medicinal Chemistry. 5: 1807-15. PMID 9354236 DOI: 10.1016/S0968-0896(97)00113-2 |
0.777 |
|
| 1997 |
Cline SD, Macdonald TL, Osheroff N. Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine. Biochemistry. 36: 13095-101. PMID 9335572 DOI: 10.1021/Bi971770Z |
0.31 |
|
| 1997 |
Thompson CD, Vachaspati PR, Kolis SP, Gulden PH, Garst ME, Wiese A, Munk SA, Harman WD, Macdonald TL. A proposed mechanism for p-aminoclonidine allergenicity based on its relative oxidative lability. Chemical Research in Toxicology. 10: 1032-6. PMID 9305586 DOI: 10.1021/tx9700735 |
0.782 |
|
| 1997 |
Thompson CD, Macdonald TL, Garst ME, Wiese A, Munk SA. Mechanisms of adrenergic agonist induced allergy bioactivation and antigen formation. Experimental Eye Research. 64: 767-73. PMID 9245907 DOI: 10.1006/Exer.1996.0267 |
0.309 |
|
| 1997 |
Lynch KR, Hopper DW, Carlisle SJ, Catalano JG, Zhang M, MacDonald TL. Structure/activity relationships in lysophosphatidic acid: the 2-hydroxyl moiety. Molecular Pharmacology. 52: 75-81. PMID 9224815 DOI: 10.1124/Mol.52.1.75 |
0.356 |
|
| 1997 |
Thompson CD, Gulden PH, Macdonald TL. Identification of modified atropaldehyde mercapturic acids in rat and human urine after felbamate administration. Chemical Research in Toxicology. 10: 457-62. PMID 9114984 DOI: 10.1021/Tx960205E |
0.327 |
|
| 1997 |
Miller TA, Bulman AL, Thompson CD, Garst ME, Macdonald TL. The synthesis and evaluation of functionalized estratropones: Potent inhibitors of tubulin polymerization Bioorganic and Medicinal Chemistry Letters. 7: 1851-1856. DOI: 10.1016/S0960-894X(97)00327-2 |
0.351 |
|
| 1996 |
Thompson CD, Kinter MT, Macdonald TL. Synthesis and in vitro reactivity of 3-carbamoyl-2-phenylpropionaldehyde and 2-phenylpropenal: putative reactive metabolites of felbamate. Chemical Research in Toxicology. 9: 1225-9. PMID 8951223 DOI: 10.1021/Tx9601566 |
0.393 |
|
| 1996 |
Tepe JJ, Madalengoitia JS, Slunt KM, Werbovetz KW, Spoors PG, Macdonald TL. Inhibition of DNA topoisomerase II by azaelliptitoxins functionalized in the variable substituent domain. Journal of Medicinal Chemistry. 39: 2188-96. PMID 8667362 DOI: 10.1021/jm9508806 |
0.773 |
|
| 1996 |
Hopper DW, Catalano JG, Macdonald TL. Facile synthesis of lysophospholipids containing unsaturated fatty acid chains Tetrahedron Letters. 37: 7871-7874. DOI: 10.1016/0040-4039(96)01802-3 |
0.307 |
|
| 1994 |
Lehnert EK, Miller KE, Madalengoitia JS, Guzi TJ, MacDonald TL. DNA topoisomerase II inhibition by substituted 1,2,3,4-tetrahydro-β-carboline derivatives Bioorganic and Medicinal Chemistry Letters. 4: 2411-2416. DOI: 10.1016/S0960-894X(01)80400-5 |
0.696 |
|
| 1993 |
Andres CJ, Macdonald TL, Ocain TD, Longhi D. Conformationally defined analogs of prolylamides. trans-prolyl peptidomimetics Journal of Organic Chemistry. 58: 6609-6613. DOI: 10.1021/Jo00076A018 |
0.347 |
|
| 1993 |
Madalengoitia JS, Macdonald TL. Synthesis of tetrahydrofurocarbazolones via intramolecular Diels-Alder reactions Tetrahedron Letters. 34: 6237-6240. DOI: 10.1016/S0040-4039(00)73719-1 |
0.697 |
|
| 1992 |
Werbovetz KA, Lehnert EK, Macdonald TL, Pearson RD. Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro. Antimicrobial Agents and Chemotherapy. 36: 495-7. PMID 1318684 DOI: 10.1128/Aac.36.2.495 |
0.367 |
|
| 1991 |
Huber SK, Werbovetz KA, Obaza-Nutaitis J, Lehnert EK, Macdonald TL. Tubulin binding of conformationally restricted bis-aryl compounds Bioorganic and Medicinal Chemistry Letters. 1: 243-246. DOI: 10.1016/S0960-894X(01)81034-9 |
0.316 |
|
| 1990 |
Hastie SB, Macdonald TL. Binding of colchiceine to tubulin. Mechanisms of ligand association with tubulin. Biochemical Pharmacology. 39: 1271-6. PMID 2322310 DOI: 10.1016/0006-2952(90)90002-3 |
0.34 |
|
| 1989 |
Macdonald TL, Delahunty CM, Mead K, O'Dell DE. Carbonyl-initiated cyclization of tetraalkylstannanes Tetrahedron Letters. 30: 1473-1476. DOI: 10.1016/S0040-4039(00)99494-2 |
0.331 |
|
| 1988 |
Goswami A, Macdonald TL, Hubbard C, Duffel MW, Rosazza JP. Leurosine biotransformations: an unusual ring-fission reaction catalyzed by peroxidase. Chemical Research in Toxicology. 1: 238-42. PMID 2979738 DOI: 10.1021/Tx00004A009 |
0.304 |
|
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