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Jui-Hua Hsieh, Ph.D. - Publications

Affiliations: 
2011 Pharmaceutical Sciences University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmacy
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Hsieh JH, Behl M, Parham F, Ryan K. Exploring the influence of experimental design on toxicity outcomes in zebrafish embryo tests. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 35639960 DOI: 10.1093/toxsci/kfac053  0.302
2021 Rooney J, Ryan N, Liu J, Houtman R, van Beuningen R, Hsieh JH, Chang G, Chen S, Corton JC. A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor α in an MCF-7 Microarray Compendium. Chemical Research in Toxicology. PMID 33405908 DOI: 10.1021/acs.chemrestox.0c00243  0.305
2020 Xia J, Wang Z, Huan Y, Xue W, Wang X, Wang YX, Liu ZM, Hsieh JH, Zhang LR, Wu S, Shen ZF, Zhang H, Wang XS. Pose Filter-based Ensemble Learning Enables Discovery of Orally Active, Nonsteroidal Farnesoid X Receptor Agonists. Journal of Chemical Information and Modeling. PMID 32050066 DOI: 10.1021/Acs.Jcim.9B01030  0.399
2019 Delp J, Gutbier S, Klima S, Hoelting L, Pinto-Gil K, Hsieh JH, Aichem M, Klein K, Schreiber F, Tice RR, Pastor M, Behl M, Leist M. Corrigendum to A high-throughput approach to identify specific neurotoxicants / developmental toxicants in human neuronal cell function assays. Altex. 36: 505. PMID 31329253 DOI: 10.14573/Altex.1904111  0.318
2019 Hsieh JH, Smith-Roe SL, Huang R, Sedykh A, Shockley KR, Auerbach SS, Merrick BA, Xia M, Tice RR, Witt KL. Identifying Compounds with Genotoxicity Potential Using Tox21 High-Throughput Screening Assays. Chemical Research in Toxicology. PMID 31243984 DOI: 10.1021/Acs.Chemrestox.9B00053  0.42
2019 Hasselgren C, Ahlberg E, Akahori Y, Amberg A, Anger LT, Atienzar F, Auerbach S, Beilke L, Bellion P, Benigni R, Bercu J, Booth ED, Bower D, Brigo A, Cammerer Z, ... ... Hsieh JH, et al. Genetic toxicology in silico protocol. Regulatory Toxicology and Pharmacology : Rtp. 104403. PMID 31195068 DOI: 10.1016/J.Yrtph.2019.104403  0.326
2018 Melnikov F, Hsieh JH, Sipes NS, Anastas PT. Channel Interactions and Robust Inference for Ratiometric β-lactamase Assay Data: a Tox21 Library Analysis. Acs Sustainable Chemistry & Engineering. 6: 3233-3241. PMID 32461840 DOI: 10.1021/Acssuschemeng.7B03394  0.341
2018 Lin TE, HuangFu WC, Chao MW, Sung TY, Chang CD, Chen YY, Hsieh JH, Tu HJ, Huang HL, Pan SL, Hsu KC. A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions. Frontiers in Pharmacology. 9: 1379. PMID 30564118 DOI: 10.3389/Fphar.2018.01379  0.346
2018 Behl M, Ryan K, Hsieh JH, Parham F, Shapiro AJ, Collins BJ, Sipes NS, Birnbaum LS, Bucher JR, Foster PMD, Walker NJ, Paules RS, Tice RR. Screening for Developmental Neurotoxicity at the National Toxicology Program: The Future is Here. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30496580 DOI: 10.1093/Toxsci/Kfy278  0.44
2018 Hsieh JH, Ryan K, Sedykh A, Lin JA, Shapiro AJ, Parham F, Behl M. Application of benchmark concentration (BMC) analysis on zebrafish data - a new perspective for quantifying toxicity in alternative animal models. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30321397 DOI: 10.1093/Toxsci/Kfy258  0.449
2018 Alzualde A, Behl M, Sipes NS, Hsieh JH, Alday A, Tice RR, Paules RS, Muriana A, Quevedo C. Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance. Neurotoxicology and Teratology. PMID 30312655 DOI: 10.1016/J.Ntt.2018.10.002  0.372
2018 Klaren WD, Ring C, Harris MA, Thompson CM, Borghoff S, Sipes NS, Hsieh JH, Auerbach SS, Rager JE. Identifying Attributes that Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity versus In Vivo DrugMatrix Transcriptomic Responses across 130 Chemicals. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30202884 DOI: 10.1093/Toxsci/Kfy220  0.414
2018 Casey WM, Chang X, Allen DG, Ceger PC, Choksi NY, Hsieh JH, Wetmore BA, Ferguson SS, DeVito MJ, Sprankle CS, Kleinstreuer NC. Evaluation and Optimization of Pharmacokinetic Models for in Vitro to in Vivo Extrapolation of Estrogenic Activity for Environmental Chemicals. Environmental Health Perspectives. 126: 97001. PMID 30192161 DOI: 10.1289/Ehp1655  0.344
2018 Delp J, Gutbier S, Klima S, Hoelting L, Pinto-Gil K, Hsieh JH, Aichem M, Klein K, Schreiber F, Tice RR, Pastor M, Behl M, Leist M. A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays. Altex. PMID 29423527 DOI: 10.14573/Altex.1712182  0.416
2018 Hur J, Danes L, Hsieh JH, McGregor B, Krout D, Auerbach S. Tox21 Enricher: Web-based Chemical/Biological Functional Annotation Analysis Tool Based on Tox21 Toxicity Screening Platform. Molecular Informatics. PMID 29377626 DOI: 10.1002/Minf.201700129  0.33
2017 Lynch C, Zhao J, Huang R, Kanaya N, Bernal L, Hsieh JH, Auerbach SS, Witt KL, Merrick BA, Chen S, Teng CT, Xia M. Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library. Endocrinology. PMID 29216352 DOI: 10.1210/En.2017-00658  0.381
2017 Chou WC, Hsu CY, Ho CC, Hsieh JH, Chiang HC, Tsou TC, Chen YC, Lin P. Development of an in Vitro-Based Risk Assessment Framework for Predicting Ambient Particulate Matter-Bound Polycyclic Aromatic Hydrocarbon-Activated Toxicity Pathways. Environmental Science & Technology. PMID 29192765 DOI: 10.1021/Acs.Est.7B02002  0.317
2017 Sipes NS, Wambaugh JF, Pearce R, Auerbach SS, Wetmore BA, Hsieh JH, Shapiro AJ, Svoboda D, DeVito MJ, Ferguson SS. An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library. Environmental Science & Technology. PMID 28809115 DOI: 10.1021/Acs.Est.7B00650  0.406
2017 Xia J, Hsieh JH, Hu H, Wu S, Wang XS. The Development of Target-Specific Pose Filter Ensembles to Boost Ligand Enrichment for Structure-Based Virtual Screening. Journal of Chemical Information and Modeling. PMID 28511009 DOI: 10.1021/Acs.Jcim.6B00749  0.4
2016 Hsu CW, Hsieh JH, Huang R, Pijnenburg D, Khuc T, Hamm J, Zhao J, Lynch C, van Beuningen R, Chang X, Houtman R, Xia M. Differential modulation of FXR activity by chlorophacinone and ivermectin analogs. Toxicology and Applied Pharmacology. PMID 27773686 DOI: 10.1016/J.Taap.2016.10.017  0.411
2016 Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to C. elegans. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27566445 DOI: 10.1093/Toxsci/Kfw162  0.315
2016 Ryan KR, Sirenko O, Parham F, Hsieh JH, Cromwell EF, Tice RR, Behl M. Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high- throughput screen for developmental neurotoxicity or neurotoxicity. Neurotoxicology. PMID 26854185 DOI: 10.1016/J.Neuro.2016.02.003  0.416
2015 Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, Jarema K, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicology and Teratology. PMID 26386178 DOI: 10.1016/J.Ntt.2015.09.003  0.4
2015 Chen S, Hsieh JH, Huang R, Sakamuru S, Hsin LY, Xia M, Shockley KR, Auerbach S, Kanaya N, Lu H, Svoboda D, Witt KL, Merrick BA, Teng CT, Tice RR. Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26141389 DOI: 10.1093/Toxsci/Kfv141  0.443
2015 Hsieh JH, Sedykh A, Huang R, Xia M, Tice RR. A Data Analysis Pipeline Accounting for Artifacts in Tox21 Quantitative High-Throughput Screening Assays. Journal of Biomolecular Screening. PMID 25904095 DOI: 10.1177/1087057115581317  0.405
2015 Behl M, Hsieh J, Shafer TJ, Mundy WR, Rice J, Boyd W, Freedman J, Sidney Hunter E, Jarema K, Padilla S, Tice R. Use of alternative assays to identify and prioritize potential developmental and neurotoxicity of emerging organophosphorous flame retardants Neurotoxicology and Teratology. 49: 108-109. DOI: 10.1016/J.Ntt.2015.04.032  0.314
2014 Hsu CW, Zhao J, Huang R, Hsieh JH, Hamm J, Chang X, Houck K, Xia M. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific Reports. 4: 6437. PMID 25257666 DOI: 10.1038/Srep06437  0.402
2014 Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh JH, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, et al. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Scientific Reports. 4: 5664. PMID 25012808 DOI: 10.1038/Srep05664  0.429
2014 Zhang J, Hsieh JH, Zhu H. Profiling animal toxicants by automatically mining public bioassay data: a big data approach for computational toxicology. Plos One. 9: e99863. PMID 24950175 DOI: 10.1371/Journal.Pone.0099863  0.33
2012 Tang H, Wang XS, Hsieh JH, Tropsha A. Do crystal structures obviate the need for theoretical models of GPCRs for structure-based virtual screening? Proteins. 80: 1503-21. PMID 22275072 DOI: 10.1002/Prot.24035  0.485
2012 Hsieh JH, Yin S, Wang XS, Liu S, Dokholyan NV, Tropsha A. Cheminformatics meets molecular mechanics: a combined application of knowledge-based pose scoring and physical force field-based hit scoring functions improves the accuracy of structure-based virtual screening. Journal of Chemical Information and Modeling. 52: 16-28. PMID 22017385 DOI: 10.1021/Ci2002507  0.509
2011 Hsieh JH, Yin S, Liu S, Sedykh A, Dokholyan NV, Tropsha A. Combined application of cheminformatics- and physical force field-based scoring functions improves binding affinity prediction for CSAR data sets. Journal of Chemical Information and Modeling. 51: 2027-35. PMID 21780807 DOI: 10.1021/Ci200146E  0.468
2008 Hsieh JH, Wang XS, Teotico D, Golbraikh A, Tropsha A. Differentiation of AmpC beta-lactamase binders vs. decoys using classification kNN QSAR modeling and application of the QSAR classifier to virtual screening. Journal of Computer-Aided Molecular Design. 22: 593-609. PMID 18338225 DOI: 10.1007/S10822-008-9199-2  0.582
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