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Gu Xiao, Ph.D. - Publications

Affiliations: 
2000 City University of New York, New York, NY, United States 
Area:
Molecular Biology
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23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ellison V, Polotskaia A, Xiao G, Leybengrub P, Qiu W, Lee R, Hendrickson R, Hu W, Bargonetti J. A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN. Biorxiv : the Preprint Server For Biology. PMID 38328189 DOI: 10.1101/2024.01.20.576487  0.762
2024 Madorsky Rowdo FP, Xiao G, Khramtsova GF, Nguyen J, Martini R, Stonaker B, Boateng R, Oppong JK, Adjei EK, Awuah B, Kyei I, Aitpillah FS, Adinku MO, Ankomah K, Osei-Bonsu EB, et al. Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment. Cancer Letters. 216608. PMID 38199587 DOI: 10.1016/j.canlet.2024.216608  0.74
2023 Rowdo FPM, Xiao G, Khramtsova GF, Nguyen J, Olopade OI, Martini R, Stonaker B, Boateng R, Oppong JK, Adjei EK, Awuah B, Kyei I, Aitpillah FS, Adinku MO, Ankomah K, et al. Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment. Biorxiv : the Preprint Server For Biology. PMID 38076873 DOI: 10.1101/2023.06.22.544406  0.741
2021 Annor GK, Elshabassy N, Lundine D, Conde DG, Xiao G, Ellison V, Bargonetti J. Oligomerization of Mutant p53 R273H is not Required for Gain-of-Function Chromatin Associated Activities. Frontiers in Cell and Developmental Biology. 9: 772315. PMID 34881245 DOI: 10.3389/fcell.2021.772315  0.668
2021 Wilson T, Pirovano G, Xiao G, Samuels Z, Roberts S, Viray T, Guru N, Zanzonico P, Gollub M, Pillarsetty NVK, Reiner T, Bargonetti J. PARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models. Molecular Pharmaceutics. PMID 34318678 DOI: 10.1021/acs.molpharmaceut.1c00323  0.697
2021 Ellison V, Annor GK, Freedman C, Xiao G, Lundine D, Freulich E, Prives C, Bargonetti J. Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity. Oncotarget. 12: 1128-1146. PMID 34136083 DOI: 10.18632/oncotarget.27975  0.728
2020 Xiao G, Annor GK, Fung K, Keinänen O, Zeglis BM, Bargonetti J. Targeting Triple Negative Breast Cancer with a Nucleus-Directed p53 Tetramerization Domain Peptide. Molecular Pharmaceutics. PMID 33289569 DOI: 10.1021/acs.molpharmaceut.0c00978  0.702
2020 Kim JY, Lee R, Xiao G, Forbes D, Bargonetti J. MDM2-C Functions as an E3 Ubiquitin Ligase. Cancer Management and Research. 12: 7715-7724. PMID 32904724 DOI: 10.2147/Cmar.S260943  0.725
2019 Xiao G, Lundine D, Annor GK, Canar J, Ellison V, Polotskaia A, Donabedian PL, Reiner T, Khramtsova GF, Olopade OI, Mazo A, Bargonetti J. Gain-of-Function Mutant p53 R273H Interacts with Replicating DNA and PARP1 in Breast Cancer. Cancer Research. PMID 31776133 DOI: 10.1158/0008-5472.Can-19-1036  0.789
2019 Gao C, Xiao G, Bargonetti J. Contemplations on MDMX (MDM4) driving triple negative breast cancer circulating tumor cells and metastasis. Oncotarget. 10: 5007-5010. PMID 31489110 DOI: 10.18632/Oncotarget.27134  0.732
2019 Gao C, Xiao G, Piersigilli A, Gou J, Ogunwobi O, Bargonetti J. Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells. Breast Cancer Research : Bcr. 21: 5. PMID 30642351 DOI: 10.1186/S13058-018-1094-8  0.734
2018 Gao C, Xiao G, Piersiga A, Gou J, Ogunwobi O, Bargonetti J. Abstract 5188: MDM2 and MDMX promote p53-independent initiation of circulating tumor cells from triple negative breast cancers Cancer Research. 78: 5188-5188. DOI: 10.1158/1538-7445.Am2018-5188  0.764
2017 Kundu N, Brekman A, Kim JY, Xiao G, Gao C, Bargonetti J. Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway. Oncotarget. PMID 28615518 DOI: 10.18632/Oncotarget.18147  0.775
2017 Qiu WG, Polotskaia A, Xiao G, Di L, Zhao Y, Hu W, Philip J, Hendrickson RC, Bargonetti J. Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer. Npj Breast Cancer. 3. PMID 28232952 DOI: 10.1038/s41523-016-0001-7  0.77
2017 Qiu W, Polotskaia A, Xiao G, Di L, Zhao Y, Hu W, Philip J, Hendrickson R, Bargonetti J. Abstract 2493: Identification of the mutant p53-PARP-MCM chromatin axis as a triple negative breast cancer replication stress target Cancer Research. 77: 2493-2493. DOI: 10.1158/1538-7445.Am2017-2493  0.772
2016 Qiu W, Polotskaia A, Xiao G, Di L, Philip J, Hendrikson RC, Bargonetti J. Abstract 3684: Proteome-wide triple negative breast cancer mutant p53 association index identifies chromatin unwinding for precision therapeutics Cancer Research. 76: 3684-3684. DOI: 10.1158/1538-7445.Am2016-3684  0.755
2015 Polotskaia A, Xiao G, Reynoso K, Martin C, Qiu WG, Hendrickson RC, Bargonetti J. Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. Proceedings of the National Academy of Sciences of the United States of America. 112: E1220-9. PMID 25733866 DOI: 10.1073/Pnas.1416318112  0.73
2015 Xiao G, Kue P, Bhosle R, Bargonetti J. Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction. Cell Cycle (Georgetown, Tex.). 14: 744-54. PMID 25565400 DOI: 10.1080/15384101.2014.997517  0.763
2015 Polotskaia A, Xiao G, Reynoso K, Martin C, Qiu W, Hendrickson R, Bargonetti J. Abstract 1225: Proteome-wide analysis of gain-of-function mutant p53 targets in breast cancer implicates PARP, PCNA and MCM4 as oncogenic drivers Cancer Research. 75: 1225-1225. DOI: 10.1158/1538-7445.Am2015-1225  0.754
2005 Qing G, Xiao G. Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100. The Journal of Biological Chemistry. 280: 9765-8. PMID 15677466 DOI: 10.1074/Jbc.C400502200  0.314
2002 Abbas T, Olivier M, Lopez J, Houser S, Xiao G, Kumar GS, Tomasz M, Bargonetti J. Differential activation of p53 by the various adducts of mitomycin C. The Journal of Biological Chemistry. 277: 40513-9. PMID 12183457 DOI: 10.1074/Jbc.M205495200  0.707
2000 Xiao G, Chicas A, Olivier M, Taya Y, Tyagi S, Kramer FR, Bargonetti J. A DNA damage signal is required for p53 to activate gadd45. Cancer Research. 60: 1711-9. PMID 10749144  0.793
1998 Xiao G, White D, Bargonetti J. p53 binds to a constitutively nucleosome free region of the mdm2 gene. Oncogene. 16: 1171-81. PMID 9528859 DOI: 10.1038/Sj.Onc.1201631  0.725
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