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Peter J. Sadler, Ph.D. - Publications

Affiliations: 
University of Warwick, Coventry, England, United Kingdom 
Website:
http://www2.warwick.ac.uk/fac/sci/chemistry/research/sadler/

424 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Armstrong J, Banerjee S, Schünemann V, Wolny JA, Sadler PJ. Correction to "Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex". The Journal of Physical Chemistry Letters. 14: 3912. PMID 37074055 DOI: 10.1021/acs.jpclett.3c00826  0.608
2022 Sink A, Banerjee S, Wolny JA, Imberti C, Lant EC, Walker M, Schünemann V, Sadler PJ. Kinetics and mechanism of sequential ring methyl C-H activation in cyclopentadienyl rhodium(III) complexes. Dalton Transactions (Cambridge, England : 2003). PMID 36043856 DOI: 10.1039/d2dt02079c  0.668
2022 Zhu Z, Wei L, Lai Y, Carter OWL, Banerjee S, Sadler PJ, Huang H. Photocatalytic glucose-appended bio-compatible Ir(III) anticancer complexes. Dalton Transactions (Cambridge, England : 2003). PMID 35796219 DOI: 10.1039/d2dt01134d  0.642
2022 Aldous L, Comba P, DeBeer S, Dey A, Draksharapu A, Duboc C, Itoh S, Karlin K, Kundu S, López Domene R, Maréchal JD, Mazumdar S, Mukherjee R, Parker D, Pordea A, ... ... Sadler P, et al. Small molecule activation and synthetic analogues: general discussion. Faraday Discussions. PMID 35531924 DOI: 10.1039/d2fd90012b  0.51
2022 Ash P, Chakravarty AR, Comba P, Dey A, Goswami D, Jäger CM, Karlin K, Kundu S, La Gatta S, López Domene R, Maréchal JD, Mazumdar S, Mugesh G, Pantazis D, Pordea A, ... Sadler PJ, et al. Natural and artificial enzymes and medicinal aspects: general discussion. Faraday Discussions. PMID 35510879 DOI: 10.1039/d2fd90014a  0.496
2022 Chen F, Romero-Canelón I, Habtemariam A, Song JI, Banerjee S, Clarkson GJ, Song L, Prokes I, Sadler PJ. Effect of cysteine thiols on the catalytic and anticancer activity of Ru(II) sulfonyl-ethylenediamine complexes. Dalton Transactions (Cambridge, England : 2003). 51: 4447-4457. PMID 35226015 DOI: 10.1039/d1dt03856g  0.68
2021 Banerjee S, Sadler PJ. Transfer hydrogenation catalysis in cells. Rsc Chemical Biology. 2: 12-29. PMID 34458774 DOI: 10.1039/d0cb00150c  0.639
2021 Armstrong J, Banerjee S, Schünemann V, Wolny JA, Sadler PJ. Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex. The Journal of Physical Chemistry Letters. 658-662. PMID 33393303 DOI: 10.1021/acs.jpclett.0c03292  0.604
2020 Zhang WY, Banerjee S, Hughes GM, Bridgewater HE, Song JI, Breeze BG, Clarkson GJ, Coverdale JPC, Sanchez-Cano C, Ponte F, Sicilia E, Sadler PJ. Ligand-centred redox activation of inert organoiridium anticancer catalysts. Chemical Science. 11: 5466-5480. PMID 34094073 DOI: 10.1039/d0sc00897d  0.673
2020 Shi H, Imberti C, Clarkson GJ, Sadler PJ. Axial functionalisation of photoactive diazido platinum(iv) anticancer complexes. Inorganic Chemistry Frontiers. 7: 3533-3540. PMID 33786191 DOI: 10.1039/D0Qi00685H  0.409
2020 Zhang WY, Bridgewater HE, Banerjee S, Soldevila-Barreda JJ, Clarkson GJ, Shi H, Imberti C, Sadler PJ. Ligand-Controlled Reactivity and Cytotoxicity of Cyclometalated Rhodium(III) Complexes. European Journal of Inorganic Chemistry. 2020: 1052-1060. PMID 33776557 DOI: 10.1002/ejic.201901055  0.672
2020 Zhang WY, Banerjee S, Imberti C, Clarkson GJ, Wang Q, Zhong Q, Young LS, Romero-Canelón I, Zeng M, Habtemariam A, Sadler PJ. Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry. Inorganica Chimica Acta. 503: 119396. PMID 33776131 DOI: 10.1016/j.ica.2019.119396  0.671
2020 Gandioso A, Rovira A, Shi H, Sadler PJ, Marchán V. Unexpected photoactivation pathways in a folate-receptor-targeted trans-diazido Pt(iv) anticancer pro-drug. Dalton Transactions (Cambridge, England : 2003). PMID 32815971 DOI: 10.1039/D0Dt02577A  0.357
2020 Needham RJ, Bridgewater HE, Romero-Canelón I, Habtemariam A, Clarkson GJ, Sadler PJ. Structure-activity relationships for osmium(II) arene phenylazopyridine anticancer complexes functionalised with alkoxy and glycolic substituents. Journal of Inorganic Biochemistry. 210: 111154. PMID 32771772 DOI: 10.1016/J.Jinorgbio.2020.111154  0.391
2020 Oliveira CG, Romero-Canelón I, Coverdale JPC, Maia PIS, Clarkson GJ, Deflon VM, Sadler PJ. Novel tetranuclear Pd and Pt anticancer complexes derived from pyrene thiosemicarbazones. Dalton Transactions (Cambridge, England : 2003). PMID 32602871 DOI: 10.1039/D0Dt01133A  0.372
2020 Chellan P, Sadler PJ. Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32452579 DOI: 10.1002/Chem.201904699  0.322
2020 Brooks J, Everett J, Lermyte F, Tjhin VT, Banerjee S, O'Connor PB, Morris CM, Sadler PJ, Telling ND, Collingwood JF. Label-free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy. Angewandte Chemie (International Ed. in English). PMID 32227670 DOI: 10.1002/Anie.202000239  0.623
2020 Frei A, Zuegg J, Elliott AG, Baker M, Braese S, Brown C, Chen F, G Dowson C, Dujardin G, Jung N, King AP, Mansour AM, Massi M, Moat J, Mohamed HA, ... ... Sadler PJ, et al. Metal complexes as a promising source for new antibiotics. Chemical Science. 11: 2627-2639. PMID 32206266 DOI: 10.1039/C9Sc06460E  0.301
2020 Shi H, Imberti C, Huang H, Hands-Portman I, Sadler PJ. Biotinylated photoactive Pt(iv) anticancer complexes. Chemical Communications (Cambridge, England). PMID 31990000 DOI: 10.1039/C9Cc07845B  0.35
2020 Zhang W, Banerjee S, Hughes GM, Bridgewater HE, Song J, Breeze BG, Clarkson GJ, Coverdale JPC, Sanchez-Cano C, Ponte F, Sicilia E, Sadler PJ. Ligand-centred redox activation of inert organoiridium anticancer catalysts Chemical Science. 11: 5466-5480. DOI: 10.1039/D0Sc00897D  0.411
2020 Zhang W, Banerjee S, Imberti C, Clarkson GJ, Wang Q, Zhong Q, Young LS, Romero-Canelón I, Zeng M, Habtemariam A, Sadler PJ. Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry Inorganica Chimica Acta. 503: 119396. DOI: 10.1016/J.Ica.2019.119396  0.406
2019 Shaili E, Salassa L, Woods JA, Clarkson G, Sadler PJ, Farrer NJ. Platinum(iv) dihydroxido diazido -(heterocyclic)imine complexes are potently photocytotoxic when irradiated with visible light. Chemical Science. 10: 8610-8617. PMID 31803436 DOI: 10.1039/C9Sc02644D  0.328
2019 Zhang X, Ponte F, Borfecchia E, Martini A, Sanchez-Cano C, Sicilia E, Sadler PJ. Glutathione activation of an organometallic half-sandwich anticancer drug candidate by ligand attack. Chemical Communications (Cambridge, England). PMID 31742266 DOI: 10.1039/C9Cc06725F  0.4
2019 Oliveira CG, Romero-Canelón I, Silva MM, Coverdale JPC, Maia PIS, Batista AA, Castelli S, Desideri A, Sadler PJ, Deflon VM. Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors. Dalton Transactions (Cambridge, England : 2003). PMID 31670343 DOI: 10.1039/C9Dt02570G  0.387
2019 Lermyte F, Everett J, Brooks J, Bellingeri F, Billimoria K, Sadler PJ, O'Connor PB, Telling ND, Collingwood JF. Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies. Cells. 8. PMID 31658742 DOI: 10.3390/Cells8101231  0.303
2019 Huang H, Banerjee S, Qiu K, Zhang P, Blacque O, Malcomson T, Paterson MJ, Clarkson GJ, Staniforth M, Stavros VG, Gasser G, Chao H, Sadler PJ. Targeted photoredox catalysis in cancer cells. Nature Chemistry. PMID 31548671 DOI: 10.1038/S41557-019-0328-4  0.673
2019 Ballesta A, Billy F, Coverdale JPC, Song JI, Sanchez-Cano C, Romero-Canelón I, Sadler PJ. Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells. Metallomics : Integrated Biometal Science. PMID 31528927 DOI: 10.1039/C9Mt00173E  0.37
2019 Lermyte F, Everett J, Lam YPY, Wootton CA, Brooks J, Barrow MP, Telling ND, Sadler PJ, O'Connor PB, Collingwood JF. Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 31350722 DOI: 10.1007/S13361-019-02283-7  0.305
2019 Sadler PJ, Imberti C, Zhang P, Huang H. New designs for phototherapeutic transition metal complexes. Angewandte Chemie (International Ed. in English). PMID 31310436 DOI: 10.1002/Anie.201905171  0.335
2019 Sanchez-Cano C, Gianolio D, Romero-Canelon I, Tucoulou R, Sadler PJ. Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells. Chemical Communications (Cambridge, England). 55: 7065-7068. PMID 31147664 DOI: 10.1039/C9Cc01675A  0.326
2019 Shi H, Wang Q, Venkatesh V, Feng G, Young LS, Romero-Canelón I, Zeng M, Sadler PJ. Photoactive platinum(iv) complex conjugated to a cancer-cell-targeting cyclic peptide. Dalton Transactions (Cambridge, England : 2003). PMID 31147656 DOI: 10.1039/C9Dt00909D  0.336
2019 Banerjee S, Omlor A, Wolny JA, Han Y, Lermyte F, Godfrey AE, O'Connor PB, Schünemann V, Danaie M, Sadler PJ. Generation of maghemite nanocrystals from iron-sulfur centres. Dalton Transactions (Cambridge, England : 2003). PMID 30951079 DOI: 10.1039/C9Dt00514E  0.618
2019 Wootton CA, Millett AJ, Lopez-Clavijo AF, Chiu CKC, Barrow MP, Clarkson GJ, Sadler PJ, O'Connor PB. Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation. The Analyst. PMID 30663751 DOI: 10.1039/C8An02094A  0.345
2019 Barnham KJ, Djuran MI, Murdoch PS, Ranford JD, Sadler PJ. Ring-Opened Adducts of the Anticancer Drug Carboplatin with Sulfur Amino Acids. Inorganic Chemistry. 35: 1065-1072. PMID 11666286 DOI: 10.1021/Ic950973D  0.32
2019 Shi H, Imberti C, Sadler PJ. Diazido platinum(iv) complexes for photoactivated anticancer chemotherapy Inorganic Chemistry Frontiers. 6: 1623-1638. DOI: 10.1039/C9Qi00288J  0.353
2019 Banerjee S, Capper MS, Clarkson GJ, Huang H, Sadler PJ. Dual-action platinum(II) Schiff base complexes: Photocytotoxicity and cellular imaging Polyhedron. 172: 157-166. DOI: 10.1016/J.Poly.2019.04.024  0.395
2019 Shi H, Clarkson GJ, Sadler PJ. Dual action photosensitive platinum(II) anticancer prodrugs with photoreleasable azide ligands Inorganica Chimica Acta. 489: 230-235. DOI: 10.1016/J.Ica.2019.02.016  0.404
2019 Zhang W, Bridgewater HE, Banerjee S, Soldevila-Barreda JJ, Clarkson GJ, Shi H, Imberti C, Sadler PJ. Ligand-Controlled Reactivity and Cytotoxicity of Cyclometalated Rhodium(III) Complexes European Journal of Inorganic Chemistry. 2020: 1052-1060. DOI: 10.1002/Ejic.201901055  0.387
2018 Zhang P, Huang H, Banerjee S, Clarkson G, Ge C, Imberti C, Sadler PJ. Nucleus-targeted organoiridium-albumin conjugate for photoactivated cancer therapy. Angewandte Chemie (International Ed. in English). PMID 30552796 DOI: 10.1002/Anie.201813002  0.652
2018 Vallotto C, Shaili E, Shi H, Butler JS, Wedge CJ, Newton ME, Sadler PJ. Photoactivatable platinum anticancer complex can generate tryptophan radicals. Chemical Communications (Cambridge, England). PMID 30468213 DOI: 10.1039/C8Cc06496B  0.337
2018 Shi H, Romero-Canelón I, Hreusova M, Novakova O, Venkatesh V, Habtemariam A, Clarkson GJ, Song JI, Brabec V, Sadler PJ. Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs. Inorganic Chemistry. PMID 30365308 DOI: 10.1021/Acs.Inorgchem.8B02599  0.438
2018 Coverdale JPC, Bridgewater HE, Song JI, Smith NA, Barry NPE, Bagley I, Sadler PJ, Romero Canelon I. In vivo selectivity and localization of reactive oxygen species (ROS) induction by osmium anticancer complexes that circumvent platinum-resistance. Journal of Medicinal Chemistry. PMID 30230827 DOI: 10.1021/Acs.Jmedchem.8B00958  0.384
2018 Wu Q, Liu LY, Li S, Wang FX, Li J, Qian Y, Su Z, Mao ZW, Sadler PJ, Liu HK. Rigid dinuclear ruthenium-arene complexes showing strong DNA interactions. Journal of Inorganic Biochemistry. 189: 30-39. PMID 30218888 DOI: 10.1016/J.Jinorgbio.2018.08.013  0.414
2018 Chen F, Moat J, McFeely D, Clarkson G, Hands-Portman IJ, Furner-Pardoe JP, Harrison F, Dowson CG, Sadler PJ. Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity. Journal of Medicinal Chemistry. PMID 30070838 DOI: 10.1021/Acs.Jmedchem.8B00906  0.363
2018 Huang H, Banerjee S, Sadler PJ. Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy. Chembiochem : a European Journal of Chemical Biology. PMID 30019476 DOI: 10.1002/Cbic.201800182  0.616
2018 Chen F, Romero-Canelón I, Soldevila-Barreda JJ, Song JI, Coverdale JPC, Clarkson GJ, Kasparkova J, Habtemariam A, Wills M, Brabec V, Sadler PJ. Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts. Organometallics. 37: 1555-1566. PMID 29887657 DOI: 10.1021/Acs.Organomet.8B00132  0.411
2018 Banerjee S, Soldevila-Barreda JJ, Wolny JA, Wootton CA, Habtemariam A, Romero-Canelón I, Chen F, Clarkson GJ, Prokes I, Song L, O'Connor PB, Schünemann V, Sadler PJ. New activation mechanism for half-sandwich organometallic anticancer complexes. Chemical Science. 9: 3177-3185. PMID 29732100 DOI: 10.1039/C7Sc05058E  0.699
2018 Wootton CA, Sanchez-Cano C, Lopez-Clavijo AF, Shaili E, Barrow MP, Sadler PJ, O'Connor PB. Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes. Chemical Science. 9: 2733-2739. PMID 29732057 DOI: 10.1039/C7Sc05135B  0.361
2018 Sanchez-Cano C, Romero-Canelón I, Geraki K, Sadler PJ. Microfocus x-ray fluorescence mapping of tumour penetration by an organo‑osmium anticancer complex. Journal of Inorganic Biochemistry. 185: 26-29. PMID 29730234 DOI: 10.1016/J.Jinorgbio.2018.04.014  0.316
2018 Gatti A, Habtemariam A, Romero-Canelón I, Song JI, Heer B, Clarkson GJ, Rogolino D, Sadler PJ, Carcelli M. Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity. Organometallics. 37: 891-899. PMID 29681675 DOI: 10.1021/Acs.Organomet.7B00875  0.418
2018 Sadler PJ, Chellan P, Avery V, Duffy S, Triccas J, Nagalingam G, Tam C, Cheng L, Liu J, Land K, Clarkson G, Romero I. Organometallic conjugates of the drug sulfadoxine for combatting antimicrobial resistance. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29653033 DOI: 10.1002/Chem.201801090  0.33
2018 Chen F, Soldevila-Barreda JJ, Romero-Canelón I, Coverdale JPC, Song JI, Clarkson GJ, Kasparkova J, Habtemariam A, Brabec V, Wolny JA, Schünemann V, Sadler PJ. Effect of sulfonamidoethylenediamine substituents in Ru arene anticancer catalysts on transfer hydrogenation of coenzyme NAD by formate. Dalton Transactions (Cambridge, England : 2003). PMID 29651471 DOI: 10.1039/C8Dt00438B  0.391
2018 Farrer NJ, Sharma G, Sayers R, Shaili E, Sadler PJ. Platinum(iv) azido complexes undergo copper-free click reactions with alkynes. Dalton Transactions (Cambridge, England : 2003). PMID 29480314 DOI: 10.1039/C7Dt04183G  0.388
2018 Coverdale JPC, Romero-Canelón I, Sanchez-Cano C, Clarkson GJ, Habtemariam A, Wills M, Sadler PJ. Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells. Nature Chemistry. 10: 347-354. PMID 29461524 DOI: 10.1038/Nchem.2918  0.318
2018 Venkatesh V, Sadler PJ. Platinum(IV) Prodrugs. Metal Ions in Life Sciences. 18. PMID 29394022 DOI: 10.1515/9783110470734-009  0.357
2018 Sadler PJ, Vernooij R, Joshi T, Horbury M, Graham B, Izgorodina E, Stavros V, Spiccia L, Wood B. Spectroscopic Studies on Photoinduced Reactions of the Anticancer Prodrug, trans,trans,trans-[Pt(N3)2(OH)2(py)2]. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29314368 DOI: 10.1002/Chem.201705349  0.362
2018 Vernooij RR, Joshi T, Horbury MD, Graham B, Izgorodina EI, Stavros VG, Sadler PJ, Spiccia L, Wood BR. Front Cover: Spectroscopic Studies on Photoinduced Reactions of the Anticancer Prodrug, trans,trans,trans -[Pt(N3 )2 (OH)2 (py)2 ] (Chem. Eur. J. 22/2018) Chemistry - a European Journal. 24: 5675-5675. DOI: 10.1002/Chem.201800161  0.307
2017 McQuitty RJ, Unterkofler S, Euser TG, Russell PSJ, Sadler PJ. Rapid screening of photoactivatable metallodrugs: photonic crystal fibre microflow reactor coupled to ESI mass spectrometry. Rsc Advances. 7: 37340-37348. PMID 29308187 DOI: 10.1039/C7Ra06735F  0.317
2017 Needham RJ, Habtemariam A, Barry NPE, Clarkson G, Sadler PJ. Halide Control of N,N-Coordination versus N,C-Cyclometalation and Stereospecific Phenyl Ring Deuteration of Osmium(II) p-Cymene Phenylazobenzothiazole Complexes. Organometallics. 36: 4367-4375. PMID 29249848 DOI: 10.1021/Acs.Organomet.7B00501  0.358
2017 Li J, Zhang P, Xu Y, Su Z, Qian Y, Li S, Yu T, Sadler PJ, Liu HK. A novel strategy to construct Janus metallamacrocycles with both a Ru-arene face and an imidazolium face. Dalton Transactions (Cambridge, England : 2003). 46: 16205-16215. PMID 29182689 DOI: 10.1039/C7Dt03374E  0.392
2017 Hearn JM, Hughes GM, Romero-Canelón I, Munro AF, Rubio-Ruiz B, Liu Z, Carragher NO, Sadler PJ. Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action. Metallomics : Integrated Biometal Science. PMID 29131211 DOI: 10.1039/C7Mt00242D  0.404
2017 Pitto-Barry A, Geraki K, Horbury MD, Stavros VG, Mosselmans JFW, Walton RI, Sadler PJ, Barry NPE. Controlled fabrication of osmium nanocrystals by electron, laser and microwave irradiation and characterisation by microfocus X-ray absorption spectroscopy. Chemical Communications (Cambridge, England). PMID 29057409 DOI: 10.1039/C7Cc07133G  0.647
2017 Zhang P, Chiu CKC, Huang H, Lam YPY, Habtemariam A, Malcomson T, Paterson MJ, Clarkson GJ, O'Connor PB, Chao H, Sadler PJ. Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells. Angewandte Chemie (International Ed. in English). PMID 29047228 DOI: 10.1002/Anie.201709082  0.317
2017 Xie MJ, Zhu MR, Lu CM, Jin Y, Gao LH, Li L, Zhou J, Li FF, Zhao QH, Liu HK, Sadler PJ, Sanchez-Cano C. Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV. Journal of Inorganic Biochemistry. 175: 29-35. PMID 28692886 DOI: 10.1016/J.Jinorgbio.2017.06.014  0.351
2017 Smith NA, Zhang P, Greenough SE, Horbury MD, Clarkson GJ, McFeely D, Habtemariam A, Salassa L, Stavros VG, Dowson CG, Sadler PJ. Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science. 8: 395-404. PMID 28451184 DOI: 10.1039/C6Sc03028A  0.374
2017 Venkatesh V, Mishra NK, Romero-Canelón I, Vernooij RR, Shi H, Coverdale JPC, Habtemariam A, Verma S, Sadler PJ. Supramolecular Photoactivatable Anticancer Hydrogels. Journal of the American Chemical Society. PMID 28414222 DOI: 10.1021/Jacs.7B00186  0.306
2017 Zhang P, Sadler PJ. Advances in the design of organometallic anticancer complexes Journal of Organometallic Chemistry. 839: 5-14. DOI: 10.1016/J.Jorganchem.2017.03.038  0.423
2017 Smith NA, Zhang P, Salassa L, Habtemariam A, Sadler PJ. Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes Inorganica Chimica Acta. 454: 240-246. DOI: 10.1016/J.Ica.2016.06.014  0.354
2017 Wang H, Qian Y, Wang F, Habtemariam A, Mao Z, Sadler PJ, Liu H. Ruthenium(II)-Arene Metallacycles: Crystal Structures, Interaction with DNA, and Cytotoxicity European Journal of Inorganic Chemistry. 2017: 1792-1799. DOI: 10.1002/Ejic.201601226  0.379
2017 Zhang P, Sadler PJ. Redox-Active Metal Complexes for Anticancer Therapy European Journal of Inorganic Chemistry. 2017: 1541-1548. DOI: 10.1002/Ejic.201600908  0.379
2016 Sadler PJ, Sanchez-Cano C, Romero-Canelon I, Yang Y, Hands-Portman I, Bohic S, Cloetens P. Synchrotron x-ray fluorescence nanoprobe reveals target sites for organo-osmium complex in human ovarian cancer cells. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28012260 DOI: 10.1002/Chem.201605911  0.334
2016 Needham RJ, Sanchez-Cano C, Zhang X, Romero-Canelón I, Habtemariam A, Cooper MS, Meszaros L, Clarkson GJ, Blower PJ, Sadler PJ. In-Cell Activation of Organo-Osmium(II) Anticancer Complexes. Angewandte Chemie (International Ed. in English). PMID 28000997 DOI: 10.1002/Anie.201610290  0.384
2016 Liu HK, Kostrhunova H, Habtemariam A, Kong Y, Deeth RJ, Brabec V, Sadler PJ. "Head-to-head" double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru-arene anticancer complexes. Dalton Transactions (Cambridge, England : 2003). PMID 27830851 DOI: 10.1039/C6Dt03356C  0.348
2016 Vernooij RR, Joshi T, Shaili E, Kubeil M, Appadoo DR, Izgorodina EI, Graham B, Sadler PJ, Wood BR, Spiccia L. Comprehensive Vibrational Spectroscopic Investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) Diazido Anticancer Prodrug Candidate. Inorganic Chemistry. PMID 27257848 DOI: 10.1021/Acs.Inorgchem.6B00476  0.328
2016 Fu Y, Romero MJ, Salassa L, Cheng X, Habtemariam A, Clarkson GJ, Prokes I, Rodger A, Costantini G, Sadler PJ. Os2 -Os4 Switch Controls DNA Knotting and Anticancer Activity. Angewandte Chemie (International Ed. in English). PMID 27240103 DOI: 10.1002/Anie.201602995  0.328
2016 Sousa EH, Ridnour LA, Gouveia FS, Silva CD, Wink DA, de França Lopes LG, Sadler PJ. Thiol-activated HNO release from a ruthenium anti-angiogenesis complex and HIF-1α inhibition for cancer therapy. Acs Chemical Biology. PMID 27191177 DOI: 10.1021/Acschembio.6B00222  0.341
2016 Venkatesh V, Wedge CJ, Romero-Canelón I, Habtemariam A, Sadler PJ. Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex. Dalton Transactions (Cambridge, England : 2003). PMID 27189101 DOI: 10.1039/C6Dt01382A  0.332
2016 Fu Y, Sanchez-Cano C, Soni R, Romero-Canelon I, Hearn JM, Liu Z, Wills M, Sadler PJ. The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions (Cambridge, England : 2003). PMID 27109147 DOI: 10.1039/C6Dt01242F  0.362
2016 Ude Z, Romero-Canelón I, Twamley B, Fitzgerald Hughes D, Sadler PJ, Marmion CJ. A novel dual-functioning ruthenium(II)-arene complex of an anti-microbial ciprofloxacin derivative - Anti-proliferative and anti-microbial activity. Journal of Inorganic Biochemistry. PMID 26993079 DOI: 10.1016/J.Jinorgbio.2016.02.018  0.405
2016 Carter R, Westhorpe A, Romero MJ, Habtemariam A, Gallevo CR, Bark Y, Menezes N, Sadler PJ, Sharma RA. Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes. Scientific Reports. 6: 20596. PMID 26867983 DOI: 10.1038/Srep20596  0.34
2016 Štarha P, Habtemariam A, Romero-Canelón I, Clarkson GJ, Sadler PJ. Hydrosulfide Adducts of Organo-Iridium Anticancer Complexes. Inorganic Chemistry. PMID 26863200 DOI: 10.1021/Acs.Inorgchem.5B02697  0.406
2016 Hill HA, Sadler PJ. Bringing inorganic chemistry to life with inspiration from R. J. P. Williams. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 26841789 DOI: 10.1007/S00775-016-1333-3  0.649
2016 Canelon IR, Hearn JM, Munro AF, Fu Y, Pizarro AM, Garnett MJ, McDermott U, Carragher NO, Sadler PJ. Potent organo-osmium complex shifts metabolism in epithelial ovarian cancer cells Journal of World Mitochondria Society. 2. DOI: 10.18143/Jwms_V2I2_2021  0.319
2016 Wang Y, Pitto-Barry A, Habtemariam A, Romero-Canelon I, Sadler PJ, Barry NPE. Nanoparticles of chitosan conjugated to organo-ruthenium complexes Inorganic Chemistry Frontiers. 3: 1058-1064. DOI: 10.1039/C6Qi00115G  0.664
2015 Brabec V, Pracharova J, Stepankova J, Sadler PJ, Kasparkova J. Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex. Journal of Inorganic Biochemistry. PMID 26778426 DOI: 10.1016/J.Jinorgbio.2015.12.029  0.368
2015 Pitto-Barry A, Sadler PJ, Barry NP. Dynamics of formation of Ru, Os, Ir and Au metal nanocrystals on doped graphitic surfaces. Chemical Communications (Cambridge, England). PMID 26698913 DOI: 10.1039/C5Cc09564F  0.748
2015 Shaili E, Fernández-Giménez M, Rodríguez-Astor S, Gandioso A, Sandín L, García-Vélez C, Massaguer A, Clarkson GJ, Woods JA, Sadler PJ, Marchán V. A Photoactivatable Platinum(IV) Anticancer Complex Conjugated to the RNA Ligand Guanidinoneomycin. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 18474-18486. PMID 26662220 DOI: 10.1002/Chem.201502373  0.417
2015 Greenough SE, Horbury MD, Smith NA, Sadler PJ, Paterson MJ, Stavros V. Excited State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 26632426 DOI: 10.1002/Cphc.201501075  0.353
2015 Soldevila-Barreda JJ, Habtemariam A, Romero-Canelón I, Sadler PJ. Half-sandwich rhodium(III) transfer hydrogenation catalysts: Reduction of NAD(+) and pyruvate, and antiproliferative activity. Journal of Inorganic Biochemistry. PMID 26601938 DOI: 10.1016/J.Jinorgbio.2015.10.008  0.418
2015 Sriskandakumar T, Behyan S, Habtemariam A, Sadler PJ, Kennepohl P. Electrophilic Activation of Oxidized Sulfur Ligands and Implications for the Biological Activity of Ruthenium(II) Arene Anticancer Complexes. Inorganic Chemistry. PMID 26599813 DOI: 10.1021/Acs.Inorgchem.5B02493  0.38
2015 Zou T, Sadler PJ. Speciation of precious metal anti-cancer complexes by NMR spectroscopy. Drug Discovery Today. Technologies. 16: 7-15. PMID 26547416 DOI: 10.1016/J.Ddtec.2015.08.002  0.568
2015 Barry NP, Pitto-Barry A, Tran J, Spencer SE, Johansen AM, Sanchez AM, Dove AP, O'Reilly RK, Deeth RJ, Beanland R, Sadler PJ. Osmium Atoms and Os2 Molecules Move Faster on Selenium-Doped Compared to Sulfur-Doped Boronic Graphenic Surfaces. Chemistry of Materials : a Publication of the American Chemical Society. 27: 5100-5. PMID 26525180 DOI: 10.1021/Acs.Chemmater.5B01853  0.739
2015 Pitto-Barry A, Perdigao LM, Walker M, Lawrence J, Costantini G, Sadler PJ, Barry NP. Synthesis and controlled growth of osmium nanoparticles by electron irradiation. Dalton Transactions (Cambridge, England : 2003). PMID 26418726 DOI: 10.1039/C5Dt03205A  0.746
2015 Hearn JM, Romero-Canelón I, Munro AF, Fu Y, Pizarro AM, Garnett MJ, McDermott U, Carragher NO, Sadler PJ. Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26162681 DOI: 10.1073/Pnas.1500925112  0.336
2015 Millett AJ, Habtemariam A, Romero-Canelón I, Clarkson GJ, Sadler PJ. Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2-Phenylpyridine Ligands. Organometallics. 34: 2683-2694. PMID 26146437 DOI: 10.1021/Acs.Organomet.5B00097  0.417
2015 Gandioso A, Shaili E, Massaguer A, Artigas G, González-Cantó A, Woods JA, Sadler PJ, Marchán V. An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: synthesis and photoactivation studies. Chemical Communications (Cambridge, England). 51: 9169-72. PMID 25947177 DOI: 10.1039/C5Cc03180J  0.319
2015 Wang M, Lai TP, Wang L, Zhang H, Yang N, Sadler PJ, Sun H. "Anion clamp" allows flexible protein to impose coordination geometry on metal ions. Chemical Communications (Cambridge, England). 51: 7867-70. PMID 25854324 DOI: 10.1039/C4Cc09642H  0.577
2015 Coverdale JP, Sanchez-Cano C, Clarkson GJ, Soni R, Wills M, Sadler PJ. Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 8043-6. PMID 25853228 DOI: 10.1002/Chem.201500534  0.343
2015 Romero-Canelón I, Sadler PJ. Systems approach to metal-based pharmacology. Proceedings of the National Academy of Sciences of the United States of America. 112: 4187-8. PMID 25825746 DOI: 10.1073/Pnas.1503858112  0.301
2015 Soldevila-Barreda JJ, Romero-Canelón I, Habtemariam A, Sadler PJ. Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications. 6: 6582. PMID 25791197 DOI: 10.1038/Ncomms7582  0.356
2015 Soldevila-Barreda JJ, Sadler PJ. Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology. 25: 172-83. PMID 25765750 DOI: 10.1016/J.Cbpa.2015.01.024  0.303
2015 Wootton CA, Sanchez-Cano C, Liu HK, Barrow MP, Sadler PJ, O'Connor PB. Binding of an organo-osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top-Down FT-ICR mass spectrometry. Dalton Transactions (Cambridge, England : 2003). 44: 3624-32. PMID 25650025 DOI: 10.1039/C4Dt03819C  0.351
2015 Mukherjee A, Barnett MA, Venkatesh V, Verma S, Sadler PJ. Human serum transferrin fibrils: nanomineralisation in bacteria and destruction of red blood cells. Chembiochem : a European Journal of Chemical Biology. 16: 149-55. PMID 25476866 DOI: 10.1002/Cbic.201402458  0.639
2015 Barry NPE, Pitto-Barry A, Tran J, Spencer SEF, Johansen AM, Sanchez AM, Dove AP, O'Reilly RK, Deeth RJ, Beanland R, Sadler PJ. Osmium Atoms and Os2 Molecules Move Faster on Selenium-Doped Compared to Sulfur-Doped Boronic Graphenic Surfaces Chemistry of Materials. 27: 5100-5105. DOI: 10.1021/acs.chemmater.5b01853  0.586
2015 Romero-Canelón I, Phoenix B, Pitto-Barry A, Tran J, Soldevila-Barreda JJ, Kirby N, Green S, Sadler PJ, Barry NPE. Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT) Journal of Organometallic Chemistry. DOI: 10.1016/J.Jorganchem.2015.05.011  0.686
2014 Liu Z, Romero-Canelón I, Habtemariam A, Clarkson GJ, Sadler PJ. Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C(∧)N-Chelated and Pyridine Ligands. Organometallics. 33: 5324-5333. PMID 25328266 DOI: 10.1021/Om500644F  0.423
2014 Barry NP, Pitto-Barry A, Romero-Canelón I, Tran J, Soldevila-Barreda JJ, Hands-Portman I, Smith CJ, Kirby N, Dove AP, O'Reilly RK, Sadler PJ. Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity. Faraday Discussions. 175: 229-40. PMID 25270092 DOI: 10.1039/C4Fd00098F  0.768
2014 Zhu Z, Wang X, Li T, Aime S, Sadler PJ, Guo Z. Platinum(II)-gadolinium(III) complexes as potential single-molecular theranostic agents for cancer treatment. Angewandte Chemie (International Ed. in English). 53: 13225-8. PMID 25255766 DOI: 10.1002/Anie.201407406  0.395
2014 Sousa EH, de Mesquita Vieira FG, Butler JS, Basso LA, Santiago DS, Diógenes IC, Lopes LG, Sadler PJ. [Fe(CN)5(isoniazid)](3-): an iron isoniazid complex with redox behavior implicated in tuberculosis therapy. Journal of Inorganic Biochemistry. 140: 236-44. PMID 25189361 DOI: 10.1016/J.Jinorgbio.2014.08.002  0.326
2014 Greenough SE, Roberts GM, Smith NA, Horbury MD, McKinlay RG, ?urek JM, Paterson MJ, Sadler PJ, Stavros VG. Ultrafast photo-induced ligand solvolysis of cis-[Ru(bipyridine)2(nicotinamide)2](2+): experimental and theoretical insight into its photoactivation mechanism. Physical Chemistry Chemical Physics : Pccp. 16: 19141-55. PMID 25060066 DOI: 10.1039/C4Cp02359E  0.35
2014 Barry NP, Pitto-Barry A, Sanchez AM, Dove AP, Procter RJ, Soldevila-Barreda JJ, Kirby N, Hands-Portman I, Smith CJ, O'Reilly RK, Beanland R, Sadler PJ. Fabrication of crystals from single metal atoms. Nature Communications. 5: 3851. PMID 24861089 DOI: 10.1038/Ncomms4851  0.747
2014 Li H, Snelling JR, Barrow MP, Scrivens JH, Sadler PJ, O'Connor PB. Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins Journal of the American Society For Mass Spectrometry. 25: 1217-1227. PMID 24845349 DOI: 10.1007/S13361-014-0877-0  0.317
2014 Pizarro AM, McQuitty RJ, Mackay FS, Zhao Y, Woods JA, Sadler PJ. Cellular accumulation, lipophilicity and photocytotoxicity of diazido platinum(IV) anticancer complexes. Chemmedchem. 9: 1169-75. PMID 24840112 DOI: 10.1002/Cmdc.201402066  0.356
2014 Novohradsky V, Zerzankova L, Stepankova J, Kisova A, Kostrhunova H, Liu Z, Sadler PJ, Kasparkova J, Brabec V. A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex Metallomics. 6: 1491-1501. PMID 24828756 DOI: 10.1039/C4Mt00112E  0.35
2014 Van Rijt SH, Romero-Canelón I, Fu Y, Shnyder SD, Sadler PJ. Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells Metallomics. 6: 1014-1022. PMID 24668459 DOI: 10.1039/C4Mt00034J  0.339
2014 Liu Z, Romero-Canelón I, Qamar B, Hearn JM, Habtemariam A, Barry NP, Pizarro AM, Clarkson GJ, Sadler PJ. The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie (International Ed. in English). 53: 3941-6. PMID 24616129 DOI: 10.1002/Anie.201311161  0.695
2014 Liu Z, Sadler PJ. Organoiridium complexes: Anticancer agents and catalysts Accounts of Chemical Research. 47: 1174-1185. PMID 24555658 DOI: 10.1021/Ar400266C  0.446
2014 Barry NP, Kemp TF, Sadler PJ, Hanna JV. A multinuclear 1H, 13C and 11B solid-state MAS NMR study of 16- and 18-electron organometallic ruthenium and osmium carborane complexes. Dalton Transactions (Cambridge, England : 2003). 43: 4945-9. PMID 24554004 DOI: 10.1039/C3Dt53589D  0.652
2014 Wills RH, Habtemariam A, Lopez-Clavijo AF, Barrow MP, Sadler PJ, O'Connor PB. Insights into the binding sites of organometallic ruthenium anticancer compounds on peptides using ultra-high resolution mass spectrometry Journal of the American Society For Mass Spectrometry. 25: 662-672. PMID 24488754 DOI: 10.1007/S13361-013-0819-2  0.346
2014 Novohradsky V, Liu Z, Vojtiskova M, Sadler PJ, Brabec V, Kasparkova J. Mechanism of cellular accumulation of an iridium(III) pentamethylcyclopentadienyl anticancer complex containing a C,N-chelating ligand Metallomics. 6: 682-690. PMID 24448555 DOI: 10.1039/C3Mt00341H  0.408
2014 Hearn JM, Romero-Canelón I, Ying F, Wild DL, Sadler PJ. Abstract 5452: Whole transcriptome analysis of ovarian cancer cells reveals the mechanism of action for a potent organometallic anticancer agent Cancer Research. 74: 5452-5452. DOI: 10.1158/1538-7445.Am2014-5452  0.313
2014 Liu Z, Sadler PJ. Formation of glutathione sulfenate and sulfinate complexes by an organoiridium(III) anticancer complex Inorganic Chemistry Frontiers. 1: 668-672. DOI: 10.1039/C4Qi00098F  0.374
2013 Zhao Y, Farrer NJ, Li H, Butler JS, McQuitty RJ, Habtemariam A, Wang F, Sadler PJ. De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie (International Ed. in English). 52: 13633-7. PMID 24167018 DOI: 10.1002/Anie.201307505  0.342
2013 Fu Y, Soni R, Romero MJ, Pizarro AM, Salassa L, Clarkson GJ, Hearn JM, Habtemariam A, Wills M, Sadler PJ. Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 15199-209. PMID 24114923 DOI: 10.1002/Chem.201302183  0.371
2013 Wu K, Liu S, Luo Q, Hu W, Li X, Wang F, Zheng R, Cui J, Sadler PJ, Xiang J, Shi Q, Xiong S. Thymines in single-stranded oligonucleotides and G-quadruplex DNA are competitive with guanines for binding to an organoruthenium anticancer complex Inorganic Chemistry. 52: 11332-11342. PMID 24024654 DOI: 10.1021/Ic401606V  0.302
2013 Lin Y, Huang Y, Zheng W, Wang F, Habtemariam A, Luo Q, Li X, Wu K, Sadler PJ, Xiong S. Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase π Journal of Inorganic Biochemistry. 128: 77-84. PMID 23942162 DOI: 10.1016/J.Jinorgbio.2013.07.029  0.396
2013 Qi Y, Liu Z, Li H, Sadler PJ, O'Connor PB. Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation. Rapid Communications in Mass Spectrometry : Rcm. 27: 2028-32. PMID 23939971 DOI: 10.1002/Rcm.6643  0.323
2013 Romero-Canelón I, Sadler PJ. Next-generation metal anticancer complexes: Multitargeting via redox modulation Inorganic Chemistry. 52: 12276-12291. PMID 23879584 DOI: 10.1021/Ic400835N  0.404
2013 Barry NPE, Sadler PJ. Challenges for metals in medicine: How nanotechnology may help to shape the future Acs Nano. 7: 5654-5659. PMID 23837396 DOI: 10.1021/Nn403220E  0.328
2013 Smith NA, Sadler PJ. Photoactivatable metal complexes: from theory to applications in biotechnology and medicine. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 371: 20120519. PMID 23776303 DOI: 10.1098/Rsta.2012.0519  0.327
2013 Zhao Y, Woods JA, Farrer NJ, Robinson KS, Pracharova J, Kasparkova J, Novakova O, Li H, Salassa L, Pizarro AM, Clarkson GJ, Song L, Brabec V, Sadler PJ. Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 9578-91. PMID 23733242 DOI: 10.1002/Chem.201300374  0.381
2013 Hearn JM, Romero-Canelón I, Qamar B, Liu Z, Hands-Portman I, Sadler PJ. Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis Acs Chemical Biology. 8: 1335-1343. PMID 23618382 DOI: 10.1021/Cb400070A  0.422
2013 Barone CR, Coletti C, McQuitty RJ, Farrer NJ, Lorusso G, Maresca L, Marrone A, Natile G, Pacifico C, Parsons S, Re N, Sadler PJ, White FJ. Photo-isomerisation of alkenyl complexes of platinum(II): structural, spectroscopic, kinetic and computational investigations. Dalton Transactions (Cambridge, England : 2003). 42: 6840-51. PMID 23493918 DOI: 10.1039/C3Dt32354D  0.323
2013 Borfecchia E, Garino C, Salassa L, Ruiu T, Gianolio D, Zhang X, Attenkofer K, Chen LX, Gobetto R, Sadler PJ, Lamberti C. X-ray transient absorption structural characterization of the 3MLCT triplet excited state of cis-[Ru(bpy)2(py)2]2+. Dalton Transactions (Cambridge, England : 2003). 42: 6564-71. PMID 23474490 DOI: 10.1039/C3Dt32865A  0.326
2013 Liu Z, Deeth RJ, Butler JS, Habtemariam A, Newton ME, Sadler PJ. Reduction of quinones by NADH catalyzed by organoiridium complexes. Angewandte Chemie (International Ed. in English). 52: 4194-7. PMID 23471835 DOI: 10.1002/Anie.201300747  0.331
2013 Butler JS, Sadler PJ. Targeted delivery of platinum-based anticancer complexes Current Opinion in Chemical Biology. 17: 175-188. PMID 23395452 DOI: 10.1016/J.Cbpa.2013.01.004  0.311
2013 Romero-Canelón I, Salassa L, Sadler PJ. The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes: Control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway Journal of Medicinal Chemistry. 56: 1291-1300. PMID 23368735 DOI: 10.1021/Jm3017442  0.391
2013 Barry NPE, Deeth RJ, Clarkson GJ, Prokes I, Sadler PJ. Thermochromic organometallic complexes: Experimental and theoretical studies of 16- to 18-electron interconversions of adducts of arene Ru(ii) carboranes with aromatic amine ligands Dalton Transactions. 42: 2580-2587. PMID 23223796 DOI: 10.1039/C2Dt32650G  0.377
2013 Wang F, Xu J, Wu K, Weidt SK, MacKay CL, Langridge-Smith PRR, Sadler PJ. Competition between glutathione and DNA oligonucleotides for ruthenium(ii) arene anticancer complexes Dalton Transactions. 42: 3188-3195. PMID 23076358 DOI: 10.1039/C2Dt32091F  0.415
2013 Betanzos-Lara S, Habtemariam A, Sadler PJ. Transfer hydrogenation reactions of photoactivatable N,N'-chelated ruthenium(II) arene complexes Journal of the Mexican Chemical Society. 57: 160-168. DOI: 10.29356/Jmcs.V57I3.202  0.36
2012 Berners Price SJ, Dimartino MJ, Hill DT, Kuroda R, Mazid MA, Sadler PJ. Addition and Corrections: Tertiary Phosphine Complexes of Gold(I) and Gold(III) with Imido Ligands: 1H, 31P, and 15N NMR Spectroscopy, Antiinflammatory Activity, and X-ray Crystal Structure of (Phthalimido)(triethylphosphine)gold(I). Inorganic Chemistry. 25: 1072. PMID 23240901 DOI: 10.1021/Ic00227A040  0.383
2012 Romero-Canelón I, Pizarro AM, Habtemariam A, Sadler PJ. Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes Metallomics. 4: 1271-1279. PMID 23138378 DOI: 10.1039/C2Mt20189E  0.384
2012 Zhao Y, Roberts GM, Greenough SE, Farrer NJ, Paterson MJ, Powell WH, Stavros VG, Sadler PJ. Two-photon-activated ligand exchange in platinum(II) complexes. Angewandte Chemie (International Ed. in English). 51: 11263-6. PMID 23047178 DOI: 10.1002/Anie.201206283  0.369
2012 Garino C, Gallo E, Smolentsev N, Glatzel P, Gobetto R, Lamberti C, Sadler PJ, Salassa L. Resonant X-ray emission spectroscopy reveals d-d ligand-field states involved in the self-assembly of a square-planar platinum complex Physical Chemistry Chemical Physics. 14: 15278-15281. PMID 23007111 DOI: 10.1039/C2Cp42451G  0.339
2012 Butler JS, Woods JA, Farrer NJ, Newton ME, Sadler PJ. Tryptophan switch for a photoactivated platinum anticancer complex. Journal of the American Chemical Society. 134: 16508-11. PMID 22991971 DOI: 10.1021/Ja3074159  0.373
2012 Barragán F, Carrion-Salip D, Gómez-Pinto I, González-Cantó A, Sadler PJ, De Llorens R, Moreno V, González C, Massaguer A, Marchán V. Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes Bioconjugate Chemistry. 23: 1838-1855. PMID 22871231 DOI: 10.1021/Bc300173H  0.318
2012 Tai HC, Zhao Y, Farrer NJ, Anastasi AE, Clarkson G, Sadler PJ, Deeth RJ. A computational approach to tuning the photochemistry of platinum(IV) anticancer agents. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 10630-42. PMID 22807241 DOI: 10.1002/Chem.201200782  0.401
2012 Betanzos-Lara S, Novakova O, Deeth RJ, Pizarro AM, Clarkson GJ, Liskova B, Brabec V, Sadler PJ, Habtemariam A. Bipyrimidine ruthenium(II) arene complexes: Structure, reactivity and cytotoxicity Journal of Biological Inorganic Chemistry. 17: 1033-1051. PMID 22791215 DOI: 10.1007/S00775-012-0917-9  0.415
2012 Westendorf AF, Woods JA, Korpis K, Farrer NJ, Salassa L, Robinson K, Appleyard V, Murray K, Grünert R, Thompson AM, Sadler PJ, Bednarski PJ. Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: a light-activated antitumor platinum complex that kills human cancer cells by an apoptosis-independent mechanism. Molecular Cancer Therapeutics. 11: 1894-904. PMID 22710878 DOI: 10.1158/1535-7163.Mct-11-0959  0.403
2012 Tai HC, Brodbeck R, Kasparkova J, Farrer NJ, Brabec V, Sadler PJ, Deeth RJ. Combined theoretical and computational study of interstrand DNA guanine-guanine cross-linking by trans-[Pt(pyridine)2] derived from the photoactivated prodrug trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorganic Chemistry. 51: 6830-41. PMID 22668523 DOI: 10.1021/Ic3005745  0.329
2012 Noffke AL, Habtemariam A, Pizarro AM, Sadler PJ. Designing organometallic compounds for catalysis and therapy Chemical Communications. 48: 5219-5246. PMID 22517189 DOI: 10.1039/C2Cc30678F  0.393
2012 Ross A, Choi JH, Hunter TM, Pannecouque C, Moggach SA, Parsons S, De Clercq E, Sadler PJ. Zinc(II) complexes of constrained antiviral macrocycles. Dalton Transactions (Cambridge, England : 2003). 41: 6408-18. PMID 22466936 DOI: 10.1039/C2Dt30140G  0.398
2012 Pracharova J, Zerzankova L, Stepankova J, Novakova O, Farrer NJ, Sadler PJ, Brabec V, Kasparkova J. Interactions of DNA with a new platinum(IV) azide dipyridine complex activated by UVA and visible light: Relationship to toxicity in tumor cells Chemical Research in Toxicology. 25: 1099-1111. PMID 22420335 DOI: 10.1021/Tx300057Y  0.35
2012 Betanzos-Lara S, Liu Z, Habtemariam A, Pizarro AM, Qamar B, Sadler PJ. Organometallic ruthenium and iridium transfer-hydrogenation catalysts using coenzyme NADH as a cofactor. Angewandte Chemie (International Ed. in English). 51: 3897-900. PMID 22415924 DOI: 10.1002/Anie.201108175  0.362
2012 Mukherjee A, Bilton PR, Mackay L, Janoschka A, Zhu H, Rea D, Langridge-Smith PR, Campopiano DJ, Teschner T, Trautwein AX, Schünemann V, Sadler PJ. Ferric ion (hydr)oxo clusters in the "Venus flytrap" cleft of FbpA: Mössbauer, calorimetric and mass spectrometric studies. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 573-88. PMID 22349975 DOI: 10.1007/S00775-012-0878-Z  0.643
2012 Barry NPE, Sadler PJ. Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: Biological relevance and synthetic strategies Chemical Society Reviews. 41: 3264-3279. PMID 22307021 DOI: 10.1039/C2Cs15300A  0.378
2012 Wu K, Luo Q, Hu W, Li X, Wang F, Xiong S, Sadler PJ. Mechanism of interstrand migration of organoruthenium anticancer complexes within a DNA duplex. Metallomics : Integrated Biometal Science. 4: 139-48. PMID 22262368 DOI: 10.1039/C2Mt00162D  0.352
2012 Fu Y, Romero MJ, Habtemariam A, Snowden ME, Song L, Clarkson GJ, Qamar B, Pizarro AM, Unwin PR, Sadler PJ. The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes Chemical Science. 3: 2485-2494. DOI: 10.1039/C2Sc20220D  0.444
2012 Soldevila-Barreda JJ, Bruijnincx PCA, Habtemariam A, Clarkson GJ, Deeth RJ, Sadler PJ. Improved catalytic activity of ruthenium-arene complexes in the reduction of NAD + Organometallics. 31: 5958-5967. DOI: 10.1021/Om3006307  0.392
2012 Betanzos-Lara S, Salassa L, Habtemariam A, Novakova O, Pizarro AM, Clarkson GJ, Liskova B, Brabec V, Sadler PJ. Photoactivatable organometallic pyridyl ruthenium(II) arene complexes Organometallics. 31: 3466-3479. DOI: 10.1021/Om201177Y  0.375
2012 Ragazzon G, Bratsos I, Alessio E, Salassa L, Habtemariam A, McQuitty RJ, Clarkson GJ, Sadler PJ. Design of photoactivatable metallodrugs: Selective and rapid light-induced ligand dissociation from half-sandwich [Ru([9]aneS 3)(N-N′)(py)] 2+ complexes Inorganica Chimica Acta. 393: 230-238. DOI: 10.1016/J.Ica.2012.06.031  0.426
2011 Betanzos-Lara S, Habtemariam A, Clarkson GJ, Sadler PJ. Organometallic cis-Dichlorido Ruthenium(II) Ammine Complexes. European Journal of Inorganic Chemistry. 2011: 3257-3264. PMID 23956682 DOI: 10.1002/Ejic.201100250  0.418
2011 Li H, Lin TY, Van Orden SL, Zhao Y, Barrow MP, Pizarro AM, Qi Y, Sadler PJ, O'Connor PB. Use of top-down and bottom-up Fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs. Analytical Chemistry. 83: 9507-15. PMID 22032417 DOI: 10.1021/Ac202267G  0.35
2011 Han Y, Luo Q, Hao X, Li X, Wang F, Hu W, Wu K, Lü S, Sadler PJ. Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide--a model for the active-site cysteine of protein tyrosine phosphatase 1B. Dalton Transactions (Cambridge, England : 2003). 40: 11519-29. PMID 21960108 DOI: 10.1039/C1Dt11189B  0.388
2011 Farrer NJ, Gierth P, Sadler PJ. Probing platinum azido complexes by 14N and 15N NMR spectroscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 12059-66. PMID 21922574 DOI: 10.1002/Chem.201101409  0.372
2011 Ronconi L, Pizarro AM, McQuitty RJ, Sadler PJ. Insights into the acid-base properties of Pt(IV)-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 12051-8. PMID 21922567 DOI: 10.1002/Chem.201002792  0.382
2011 Fu Y, Habtemariam A, Basri AM, Braddick D, Clarkson GJ, Sadler PJ. Structure-activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity. Dalton Transactions (Cambridge, England : 2003). 40: 10553-62. PMID 21860862 DOI: 10.1039/C1Dt10937E  0.398
2011 Barragán F, López-Senín P, Salassa L, Betanzos-Lara S, Habtemariam A, Moreno V, Sadler PJ, Marchán V. Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex. Journal of the American Chemical Society. 133: 14098-108. PMID 21797210 DOI: 10.1021/Ja205235M  0.363
2011 Liu Z, Salassa L, Habtemariam A, Pizarro AM, Clarkson GJ, Sadler PJ. Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry. 50: 5777-83. PMID 21618978 DOI: 10.1021/Ic200607J  0.412
2011 Hu W, Luo Q, Wu K, Li X, Wang F, Chen Y, Ma X, Wang J, Liu J, Xiong S, Sadler PJ. The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Chemical Communications (Cambridge, England). 47: 6006-8. PMID 21526258 DOI: 10.1039/C1Cc11627D  0.303
2011 Kisova A, Zerzankova L, Habtemariam A, Sadler PJ, Brabec V, Kasparkova J. Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics. 8: 949-57. PMID 21480648 DOI: 10.1021/Mp200105D  0.367
2011 Westendorf AF, Zerzankova L, Salassa L, Sadler PJ, Brabec V, Bednarski PJ. Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]. Journal of Inorganic Biochemistry. 105: 652-62. PMID 21450268 DOI: 10.1016/J.Jinorgbio.2011.01.003  0.385
2011 Liu HK, Sadler PJ. Metal complexes as DNA intercalators. Accounts of Chemical Research. 44: 349-59. PMID 21446672 DOI: 10.1021/Ar100140E  0.413
2011 Liu Z, Habtemariam A, Pizarro AM, Fletcher SA, Kisova A, Vrana O, Salassa L, Bruijnincx PC, Clarkson GJ, Brabec V, Sadler PJ. Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry. 54: 3011-26. PMID 21443199 DOI: 10.1021/Jm2000932  0.413
2011 Rijt SH, Kostrhunova H, Brabec V, Sadler PJ. Functionalization of osmium arene anticancer complexes with (poly)arginine: effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate Chemistry. 22: 218-26. PMID 21271713 DOI: 10.1021/Bc100369P  0.36
2011 Ronconi L, Sadler PJ. Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]. Dalton Transactions (Cambridge, England : 2003). 40: 262-8. PMID 21076743 DOI: 10.1039/C0Dt00546K  0.371
2011 Best SL, Guo Z, Djuran MI, Sadler PJ. [AU(DIEN)Cl]Cl(2): Exchange Phenomena Observed by H and C NMR Spectroscopy. Metal-Based Drugs. 6: 261-9. PMID 18475901 DOI: 10.1155/Mbd.1999.261  0.374
2011 Sevillano P, García ME, Habtemariam A, Parsons S, Sadler PJ. Different coordination modes of a tripod phosphine in gold(i) and silver(i) complexes. Metal-Based Drugs. 6: 211-21. PMID 18475895 DOI: 10.1155/Mbd.1999.211  0.364
2011 Graham GG, Gordon D, Sadler PJ. Reactions of the Antiarthritic Drug Aurothiomalate With Phenylmercury(II) Compounds: NMR Studies. Metal-Based Drugs. 3: 269-76. PMID 18475757 DOI: 10.1155/Mbd.1996.269  0.404
2011 Dhubhghaill OM, Sadler PJ, Fernandez EG. Cytotoxic Phosphinoarsino and Diphosphino Pd(II) Complexes of Thiolate Amino Acids and Glutathione. Metal-Based Drugs. 2: 19-35. PMID 18472743 DOI: 10.1155/Mbd.1995.19  0.324
2011 Shnyder SD, Fu Y, Habtemariam A, Van Rijt SH, Cooper PA, Loadman PM, Sadler PJ. Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex Medchemcomm. 2: 666-668. DOI: 10.1039/C1Md00075F  0.345
2011 Liu Z, Habtemariam A, Pizarro AM, Clarkson GJ, Sadler PJ. Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-Chelating ligands Organometallics. 30: 4702-4710. DOI: 10.1021/Om2005468  0.414
2010 Salassa L, Borfecchia E, Ruiu T, Garino C, Gianolio D, Gobetto R, Sadler PJ, Cammarata M, Wulff M, Lamberti C. Photo-induced pyridine substitution in cis-[Ru(bpy)(2)(py)(2)]Cl(2): a snapshot by time-resolved X-ray solution scattering. Inorganic Chemistry. 49: 11240-8. PMID 21038911 DOI: 10.1021/Ic102021K  0.349
2010 Fu Y, Habtemariam A, Pizarro AM, van Rijt SH, Healey DJ, Cooper PA, Shnyder SD, Clarkson GJ, Sadler PJ. Organometallic osmium arene complexes with potent cancer cell cytotoxicity. Journal of Medicinal Chemistry. 53: 8192-6. PMID 20977192 DOI: 10.1021/Jm100560F  0.351
2010 Farrer NJ, Woods JA, Salassa L, Zhao Y, Robinson KS, Clarkson G, Mackay FS, Sadler PJ. A potent trans-diimine platinum anticancer complex photoactivated by visible light. Angewandte Chemie (International Ed. in English). 49: 8905-8. PMID 20677309 DOI: 10.1002/Anie.201003399  0.347
2010 Cubo L, Pizarro AM, Quiroga AG, Salassa L, Navarro-Ranninger C, Sadler PJ. Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. Journal of Inorganic Biochemistry. 104: 909-18. PMID 20546905 DOI: 10.1016/J.Jinorgbio.2010.04.009  0.393
2010 Shi Y, Harvey I, Campopiano D, Sadler PJ. Niobium uptake and release by bacterial ferric ion binding protein. Bioinorganic Chemistry and Applications. 307578. PMID 20445753 DOI: 10.1155/2010/307578  0.301
2010 Novakova O, Malina J, Suchankova T, Kasparkova J, Bugarcic T, Sadler PJ, Brabec V. Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru(II) complexes containing terphenyl arenes. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 5744-54. PMID 20376825 DOI: 10.1002/Chem.200903078  0.328
2010 Pizarro AM, Melchart M, Habtemariam A, Salassa L, Fabbiani FP, Parsons S, Sadler PJ. Controlling the reactivity of ruthenium(II) arene complexes by tether ring-opening. Inorganic Chemistry. 49: 3310-9. PMID 20205442 DOI: 10.1021/Ic902243Q  0.378
2010 Ross A, Soares DC, Covelli D, Pannecouque C, Budd L, Collins A, Robertson N, Parsons S, De Clercq E, Kennepohl P, Sadler PJ. Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists. Inorganic Chemistry. 49: 1122-32. PMID 20039648 DOI: 10.1021/Ic9020614  0.397
2010 van Rijt SH, Mukherjee A, Pizarro AM, Sadler PJ. Cytotoxicity, hydrophobicity, uptake, and distribution of osmium(II) anticancer complexes in ovarian cancer cells. Journal of Medicinal Chemistry. 53: 840-9. PMID 20000847 DOI: 10.1021/Jm901556U  0.691
2010 Farrer NJ, Woods JA, Munk VP, Mackay FS, Sadler PJ. Photocytotoxic trans-diam(m)ine platinum(IV) diazido complexes more potent than their cis isomers. Chemical Research in Toxicology. 23: 413-21. PMID 19994893 DOI: 10.1021/Tx900372P  0.37
2010 Bergamo A, Masi A, Peacock AF, Habtemariam A, Sadler PJ, Sava G. In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model. Journal of Inorganic Biochemistry. 104: 79-86. PMID 19906432 DOI: 10.1016/J.Jinorgbio.2009.10.005  0.334
2010 Salassa L, Garino C, Salassa G, Nervi C, Gobetto R, Lamberti C, Gianolio D, Bizzarri R, Sadler PJ. Ligand-selective photodissociation from [Ru(bpy)(4AP)4]2+: a spectroscopic and computational study. Inorganic Chemistry. 48: 1469-81. PMID 19149466 DOI: 10.1021/Ic8015436  0.347
2010 Salassa L, Ruiu T, Garino C, Pizarro AM, Bardelli F, Gianolio D, Westendorf A, Bednarski PJ, Lamberti C, Gobetto R, Sadler PJ. EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+ Organometallics. 29: 6703-6710. DOI: 10.1021/Om100734Y  0.384
2010 Ruiu T, Garino C, Salassa L, Pizarro AM, Nervi C, Gobetto R, Sadler PJ. Spectroscopic and computational study of ligand photodissociation from [Ru(dipyrido[3,2-a2′:3′-c]phenazine)(4-aminopyridine) 4]2+ European Journal of Inorganic Chemistry. 1186-1195. DOI: 10.1002/Ejic.200900990  0.352
2010 Farrer NJ, Woods JA, Salassa L, Zhao Y, Robinson KS, Clarkson G, Mackay FS, Sadler PJ. Inside Cover: A Potent Trans-Diimine Platinum Anticancer Complex Photoactivated by Visible Light (Angew. Chem. Int. Ed. 47/2010) Angewandte Chemie International Edition. 49: 8766-8766. DOI: 10.1002/Anie.201004988  0.332
2010 Farrer NJ, Woods JA, Salassa L, Zhao Y, Robinson KS, Clarkson G, Mackay FS, Sadler PJ. Innentitelbild: A Potent Trans-Diimine Platinum Anticancer Complex Photoactivated by Visible Light (Angew. Chem. 47/2010) Angewandte Chemie. 122: 8948-8948. DOI: 10.1002/Ange.201004988  0.337
2009 Farrer NJ, Salassa L, Sadler PJ. Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine. Dalton Transactions (Cambridge, England : 2003). 10690-701. PMID 20023896 DOI: 10.1039/B917753A  0.35
2009 Salassa L, Phillips HI, Sadler PJ. Decomposition pathways for the photoactivated anticancer complex cis,trans,cis-[Pt(N3)2(OH)2(NH3)2]: insights from DFT calculations. Physical Chemistry Chemical Physics : Pccp. 11: 10311-6. PMID 19890514 DOI: 10.1039/B912496A  0.335
2009 Betanzos-Lara S, Salassa L, Habtemariam A, Sadler PJ. Photocontrolled nucleobase binding to an organometallic Ru(II) arene complex. Chemical Communications (Cambridge, England). 6622-4. PMID 19865670 DOI: 10.1039/B914153G  0.399
2009 Van Rijt SH, Hebden AJ, Amaresekera T, Deeth RJ, Clarkson GJ, Parsons S, McGowan PC, Sadler PJ. Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes Journal of Medicinal Chemistry. 52: 7753-7764. PMID 19791745 DOI: 10.1021/Jm900731J  0.345
2009 Bugarcic T, Habtemariam A, Deeth RJ, Fabbiani FPA, Parsons S, Sadler PJ. Ruthenium(ll) arene anticancer complexes with redox-active diamine ligands Inorganic Chemistry. 48: 9444-9453. PMID 19780621 DOI: 10.1021/Ic9013366  0.375
2009 Sriskandakumar T, Petzold H, Bruijnincx PC, Habtemariam A, Sadler PJ, Kennepohl P. Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. Journal of the American Chemical Society. 131: 13355-61. PMID 19719101 DOI: 10.1021/Ja903405Z  0.384
2009 Hu W, Luo Q, Ma X, Wu K, Liu J, Chen Y, Xiong S, Wang J, Sadler PJ, Wang F. Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 6586-94. PMID 19533706 DOI: 10.1002/Chem.200900699  0.4
2009 Blindauer CA, Harvey I, Bunyan KE, Stewart AJ, Sleep D, Harrison DJ, Berezenko S, Sadler PJ. Structure, properties, and engineering of the major zinc binding site on human albumin. The Journal of Biological Chemistry. 284: 23116-24. PMID 19520864 DOI: 10.1074/Jbc.M109.003459  0.312
2009 Wang F, Habtemariam A, van der Geer EP, Deeth RJ, Gould R, Parsons S, Sadler PJ. Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 14: 1065-76. PMID 19499253 DOI: 10.1007/S00775-009-0549-X  0.43
2009 Pizarro AM, Sadler PJ. Unusual DNA binding modes for metal anticancer complexes Biochimie. 91: 1198-1211. PMID 19344743 DOI: 10.1016/J.Biochi.2009.03.017  0.353
2009 Mackay FS, Farrer NJ, Salassa L, Tai HC, Deeth RJ, Moggach SA, Wood PA, Parsons S, Sadler PJ. Synthesis, characterisation and photochemistry of Pt(IV) pyridyl azido acetato complexes. Dalton Transactions (Cambridge, England : 2003). 2315-25. PMID 19290364 DOI: 10.1039/B820550G  0.386
2009 Diakos CI, Messerle BA, Murdoch Pdel S, Parkinson JA, Sadler PJ, Fenton RR, Hambley TW. Identification by NMR spectroscopy of the two stereoisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz = 3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A x T-rich 14-mer DNA duplex. Inorganic Chemistry. 48: 3047-56. PMID 19265406 DOI: 10.1021/Ic802207M  0.322
2009 van Rijt SH, Peacock AF, Johnstone RD, Parsons S, Sadler PJ. Organometallic osmium(II) arene anticancer complexes containing picolinate derivatives. Inorganic Chemistry. 48: 1753-62. PMID 19146436 DOI: 10.1021/Ic8020222  0.401
2009 Phillips HI, Ronconi L, Sadler PJ. Photoinduced reactions of cis,trans,cis-[Pt(IV)(N3)2(OH)2(NH3)2) with 1-methylimidazole. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 1588-96. PMID 19140142 DOI: 10.1002/Chem.200802206  0.355
2009 Bruijnincx PCA, Sadler PJ. Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design Advances in Inorganic Chemistry. 61: 1-62. DOI: 10.1016/S0898-8838(09)00201-3  0.355
2009 Mackay FS, Moggach SA, Collins A, Parsons S, Sadler PJ. Photoactive trans ammine/amine diazido platinum(IV) complexes Inorganica Chimica Acta. 362: 811-819. DOI: 10.1016/J.Ica.2008.02.039  0.396
2009 Gray JC, Pagelot A, Collins A, Fabbiani FPA, Parsons S, Sadler PJ. Organometallic osmium(II) and ruthenium(II) biphenyl sandwich complexes: X-ray crystal structures and 187Os NMR spectroscopic studies in solution European Journal of Inorganic Chemistry. 2009: 2673-2677. DOI: 10.1002/Ejic.200900244  0.409
2008 Ronconi L, Sadler PJ. Applications of heteronuclear NMR spectroscopy in biological and medicinal inorganic chemistry. Coordination Chemistry Reviews. 252: 2239-2277. PMID 32226090 DOI: 10.1016/J.Ccr.2008.01.016  0.385
2008 Bugarcic T, Habtemariam A, Stepankova J, Heringova P, Kasparkova J, Deeth RJ, Johnstone RDL, Prescimone A, Parkin A, Parsons S, Brabec V, Sadler PJ. The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes Inorganic Chemistry. 47: 11470-11486. PMID 19007206 DOI: 10.1021/Ic801361M  0.404
2008 Peacock AF, Sadler PJ. Medicinal organometallic chemistry: designing metal arene complexes as anticancer agents. Chemistry, An Asian Journal. 3: 1890-9. PMID 18712745 DOI: 10.1002/Asia.200800149  0.381
2008 Bugarcic T, Nováková O, Halámiková A, Zerzánková L, Vrána O, Kaspárková J, Habtemariam A, Parsons S, Sadler PJ, Brabec V. Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. Journal of Medicinal Chemistry. 51: 5310-9. PMID 18702458 DOI: 10.1021/Jm8003043  0.381
2008 Dougan SJ, Habtemariam A, McHale SE, Parsons S, Sadler PJ. Catalytic organometallic anticancer complexes. Proceedings of the National Academy of Sciences of the United States of America. 105: 11628-33. PMID 18687892 DOI: 10.1073/Pnas.0800076105  0.426
2008 Gray JC, Habtemariam A, Winnig M, Meyerhof W, Sadler PJ. Sweetening ruthenium and osmium: organometallic arene complexes containing aspartame. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 13: 1111-20. PMID 18553111 DOI: 10.1007/S00775-008-0396-1  0.37
2008 Kostrhunova H, Florian J, Novakova O, Peacock AF, Sadler PJ, Brabec V. DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media. Journal of Medicinal Chemistry. 51: 3635-43. PMID 18494458 DOI: 10.1021/Jm701538W  0.375
2008 Castellano-Castillo M, Kostrhunova H, Marini V, Kasparkova J, Sadler PJ, Malinge JM, Brabec V. Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 13: 993-9. PMID 18491151 DOI: 10.1007/S00775-008-0386-3  0.332
2008 Petzold H, Xu J, Sadler PJ. Metal and ligand control of sulfenate reactivity: arene ruthenium thiolato-mono-S-oxides. Angewandte Chemie (International Ed. in English). 47: 3008-11. PMID 18327759 DOI: 10.1002/Anie.200705342  0.34
2008 Ghosh S, Mukherjee A, Sadler PJ, Verma S. Periodic iron nanomineralization in human serum transferrin fibrils. Angewandte Chemie (International Ed. in English). 47: 2217-21. PMID 18256996 DOI: 10.1002/Anie.200705723  0.626
2008 Wang F, Weidt S, Xu J, Mackay CL, Langridge-Smith PR, Sadler PJ. Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry combined with (18)O-labeling. Journal of the American Society For Mass Spectrometry. 19: 544-9. PMID 18222094 DOI: 10.1016/J.Jasms.2007.12.002  0.342
2008 Bruijnincx PC, Sadler PJ. New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology. 12: 197-206. PMID 18155674 DOI: 10.1016/J.Cbpa.2007.11.013  0.333
2008 Farrer NJ, Sadler PJ. Photochemotherapy: Targeted Activation of Metal Anticancer Complexes Australian Journal of Chemistry. 61: 669. DOI: 10.1071/Ch08088  0.366
2007 Mackay FS, Woods JA, Heringová P, Kaspárková J, Pizarro AM, Moggach SA, Parsons S, Brabec V, Sadler PJ. A potent cytotoxic photoactivated platinum complex. Proceedings of the National Academy of Sciences of the United States of America. 104: 20743-8. PMID 18093923 DOI: 10.1073/Pnas.0707742105  0.393
2007 Ronconi L, Sadler PJ. Unprecedented carbon-carbon bond formation induced by photoactivation of a platinum(IV)-diazido complex. Chemical Communications (Cambridge, England). 235-7. PMID 18092098 DOI: 10.1039/B714216A  0.358
2007 Hoeschele JD, Habtemariam A, Muir J, Sadler PJ. 106Ru radiolabelling of the antitumour complex [(eta6-fluorene)Ru(en)Cl]PF6. Dalton Transactions (Cambridge, England : 2003). 4974-9. PMID 17992282 DOI: 10.1039/B706246J  0.349
2007 Melchart M, Habtemariam A, Novakova O, Moggach SA, Fabbiani FP, Parsons S, Brabec V, Sadler PJ. Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA. Inorganic Chemistry. 46: 8950-62. PMID 17850143 DOI: 10.1021/Ic700799W  0.391
2007 Knipp M, Karotki AV, Chesnov S, Natile G, Sadler PJ, Brabec V, Vasák M. Reaction of Zn7metallothionein with cis- and trans-[Pt(N-donor)2Cl2] anticancer complexes: trans-Pt(II) complexes retain their N-donor ligands. Journal of Medicinal Chemistry. 50: 4075-86. PMID 17665893 DOI: 10.1021/Jm070271L  0.367
2007 Melchart M, Habtemariam A, Parsons S, Sadler PJ. Chlorido-, aqua-, 9-ethylguanine- and 9-ethyladenine-adducts of cytotoxic ruthenium arene complexes containing O,O-chelating ligands. Journal of Inorganic Biochemistry. 101: 1903-12. PMID 17582501 DOI: 10.1016/J.Jinorgbio.2007.04.018  0.364
2007 Magennis SW, Habtemariam A, Novakova O, Henry JB, Meier S, Parsons S, Oswald IDH, Brabec V, Sadler PJ. Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex Inorganic Chemistry. 46: 5059-5068. PMID 17497848 DOI: 10.1021/Ic062111Q  0.355
2007 Weidt SK, Mackay CL, Langridge-Smith PR, Sadler PJ. Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Chemical Communications (Cambridge, England). 1719-21. PMID 17457419 DOI: 10.1039/B701903C  0.307
2007 Peacock AF, Habtemariam A, Moggach SA, Prescimone A, Parsons S, Sadler PJ. Chloro half-sandwich osmium(II) complexes: influence of chelated N,N-ligands on hydrolysis, guanine binding, and cytotoxicity. Inorganic Chemistry. 46: 4049-59. PMID 17441712 DOI: 10.1021/Ic062350D  0.411
2007 Peacock AF, Parsons S, Sadler PJ. Tuning the hydrolytic aqueous chemistry of osmium arene complexes with N,O-chelating ligands to achieve cancer cell cytotoxicity. Journal of the American Chemical Society. 129: 3348-57. PMID 17319668 DOI: 10.1021/Ja068335P  0.426
2007 Bednarski PJ, Mackay FS, Sadler PJ. Photoactivatable platinum complexes. Anti-Cancer Agents in Medicinal Chemistry. 7: 75-93. PMID 17266506 DOI: 10.2174/187152007779314053  0.377
2007 Peacock AF, Melchart M, Deeth RJ, Habtemariam A, Parsons S, Sadler PJ. Osmium(II) and ruthenium(II) arene maltolato complexes: rapid hydrolysis and nucleobase binding. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 2601-13. PMID 17200926 DOI: 10.1002/Chem.200601152  0.399
2007 Dougan SJ, Melchart M, Habtemariam A, Parsons S, Sadler PJ. Phenylazo-pyridine and phenylazo-pyrazole chlorido ruthenium(II) arene complexes: arene loss, aquation, and cancer cell cytotoxicity. Inorganic Chemistry. 45: 10882-94. PMID 17173447 DOI: 10.1021/Ic061460H  0.426
2007 Hunter TM, McNae IW, Simpson DP, Smith AM, Moggach S, White F, Walkinshaw MD, Parsons S, Sadler PJ. Configurations of nickel-cyclam antiviral complexes and protein recognition Chemistry - a European Journal. 13: 40-50. PMID 17120266 DOI: 10.1002/Chem.200601334  0.348
2007 Dougan SJ, Sadler PJ. The Design of Organometallic Ruthenium Arene Anticancer Agents Chimia International Journal For Chemistry. 61: 704-715. DOI: 10.2533/Chimia.2007.704  0.416
2007 Ronconi L, Sadler PJ. Using coordination chemistry to design new medicines Coordination Chemistry Reviews. 251: 1633-1648. DOI: 10.1016/J.Ccr.2006.11.017  0.417
2007 Zobi F, Mood BB, Wood PA, Fabbiani FPA, Parsons S, Sadler PJ. Tagging (arene)ruthenium(II) anticancer complexes with fluorescent labels European Journal of Inorganic Chemistry. 2783-2796. DOI: 10.1002/Ejic.200700144  0.688
2006 Habtemariam A, Melchart M, Fernandez R, Parsons S, Oswald ID, Parkin A, Fabbiani FP, Davidson JE, Dawson A, Aird RE, Jodrell DI, Sadler PJ. Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands. Journal of Medicinal Chemistry. 49: 6858-68. PMID 17154516 DOI: 10.1021/Jm060596M  0.374
2006 Liu HK, Berners-Price SJ, Wang F, Parkinson JA, Xu J, Bella J, Sadler PJ. Diversity in guanine-selective DNA binding modes for an organometallic ruthenium arene complex. Angewandte Chemie (International Ed. in English). 45: 8153-6. PMID 17120267 DOI: 10.1002/Anie.200602873  0.347
2006 Munk VP, Fakih S, Socorro Murdoch PD, Sadler PJ. Reactions of PtII diamine anticancer complexes with trypanothione and octreotide. Journal of Inorganic Biochemistry. 100: 1946-54. PMID 17046064 DOI: 10.1016/J.Jinorgbio.2006.08.011  0.356
2006 Valks GC, McRobbie G, Lewis EA, Hubin TJ, Hunter TM, Sadler PJ, Pannecouque C, De Clercq E, Archibald SJ. Configurationally restricted bismacrocyclic CXCR4 receptor antagonists. Journal of Medicinal Chemistry. 49: 6162-5. PMID 17034122 DOI: 10.1021/Jm0607810  0.305
2006 Liu HK, Wang F, Parkinson JA, Bella J, Sadler PJ. Ruthenation of duplex and single-stranded d(CGGCCG) by organometallic anticancer complexes. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 6151-65. PMID 16807967 DOI: 10.1002/Chem.200600110  0.334
2006 Yan YK, Melchart M, Habtemariam A, Peacock AF, Sadler PJ. Catalysis of regioselective reduction of NAD+ by ruthenium(II) arene complexes under biologically relevant conditions. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 11: 483-8. PMID 16604356 DOI: 10.1007/S00775-006-0098-5  0.388
2006 Paradies J, Crudass J, Mackay F, Yellowlees LJ, Montgomery J, Parsons S, Oswald I, Robertson N, Sadler PJ. Photogeneration of titanium(III) from titanium(IV) citrate in aqueous solution. Journal of Inorganic Biochemistry. 100: 1260-4. PMID 16603248 DOI: 10.1016/J.Jinorgbio.2006.02.011  0.359
2006 Mackay FS, Woods JA, Moseley H, Ferguson J, Dawson A, Parsons S, Sadler PJ. A photoactivated trans-diammine platinum complex as cytotoxic as cisplatin. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 3155-61. PMID 16470886 DOI: 10.1002/Chem.200501601  0.405
2006 Peacock AF, Habtemariam A, Fernández R, Walland V, Fabbiani FP, Parsons S, Aird RE, Jodrell DI, Sadler PJ. Tuning the reactivity of osmium(II) and ruthenium(II) arene complexes under physiological conditions. Journal of the American Chemical Society. 128: 1739-48. PMID 16448150 DOI: 10.1021/Ja055886R  0.404
2006 Bednarski PJ, Grünert R, Zielzki M, Wellner A, Mackay FS, Sadler PJ. Light-activated destruction of cancer cell nuclei by platinum diazide complexes. Chemistry & Biology. 13: 61-7. PMID 16426972 DOI: 10.1016/J.Chembiol.2005.10.011  0.328
2006 McGowan G, Parsons S, Sadler PJ. Contrasting chemistry of cis- and trans-platinum(II) diamine anticancer compounds: hydrolysis studies of picoline complexes. Inorganic Chemistry. 44: 7459-67. PMID 16212372 DOI: 10.1021/Ic050763T  0.384
2006 McGowan G, Parsons S, Sadler PJ. G-G base-pairing in nucleobase adducts of the anticancer drug cis-[PtCl2(NH3)(2-picoline)] and its trans isomer. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 4396-404. PMID 15880542 DOI: 10.1002/Chem.200500122  0.389
2006 Fernández R, Melchart M, Habtemariam A, Parsons S, Sadler PJ. Use of chelating ligands to tune the reactive site of half-sandwich ruthenium(II)-arene anticancer complexes. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 5173-9. PMID 15372674 DOI: 10.1002/Chem.200400640  0.38
2006 Blindauer CA, Razi MT, Parsons S, Sadler PJ. Metal complexes of N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN): Variable coordination numbers and geometries Polyhedron. 25: 513-520. DOI: 10.1016/J.Poly.2005.08.019  0.37
2006 Berners-Price SJ, Ronconi L, Sadler PJ. Insights into the mechanism of action of platinum anticancer drugs from multinuclear NMR spectroscopy Progress in Nuclear Magnetic Resonance Spectroscopy. 49: 65-98. DOI: 10.1016/J.Pnmrs.2006.05.002  0.31
2006 Melchart M, Habtemariam A, Parsons S, Moggach SA, Sadler PJ. Ruthenium(II) arene complexes containing four- and five-membered monoanionic O,O-chelate rings Inorganica Chimica Acta. 359: 3020-3028. DOI: 10.1016/J.Ica.2005.12.059  0.358
2005 Guichard SM, Else R, Reid E, Zeitlin B, Aird R, Muir M, Dodds M, Fiebig H, Sadler PJ, Jodrell DI. Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds. Biochemical Pharmacology. 71: 408-15. PMID 16360645 DOI: 10.1016/J.Bcp.2005.10.053  0.316
2005 Wang F, Habtemariam A, Van Der Geer EPL, Fernández R, Melchart M, Deeth RJ, Aird R, Guichard S, Fabbiani FPA, Lozano-Casal P, Oswald IDH, Jodrell DI, Parsons S, Sadler PJ. Controlling ligand substitution reactions of organometallic complexes: Tuning cancer cell cytotoxicity Proceedings of the National Academy of Sciences of the United States of America. 102: 18269-18274. PMID 16352726 DOI: 10.1073/Pnas.0505798102  0.392
2005 Wang F, Xu J, Habtemariam A, Bella J, Sadler PJ. Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: detection of a sulfenato intermediate. Journal of the American Chemical Society. 127: 17734-43. PMID 16351102 DOI: 10.1021/Ja053387K  0.419
2005 Yan YK, Melchart M, Habtemariam A, Sadler PJ. Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes. Chemical Communications (Cambridge, England). 4764-76. PMID 16193110 DOI: 10.1039/B508531B  0.408
2005 Wang F, Bella J, Parkinson JA, Sadler PJ. Competitive reactions of a ruthenium arene anticancer complex with histidine, cytochrome c and an oligonucleotide. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 10: 147-55. PMID 15735959 DOI: 10.1007/S00775-004-0621-5  0.367
2005 Novakova O, Kasparkova J, Bursova V, Hofr C, Vojtiskova M, Chen H, Sadler PJ, Brabec V. Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity. Chemistry & Biology. 12: 121-9. PMID 15664521 DOI: 10.1016/J.Chembiol.2004.11.008  0.373
2005 Mackay FS, Woods J, Moseley H, Sadler PJ. Photoactivated platinum(IV) anticancer complexes British Journal of Dermatology. 152: 857-858. DOI: 10.1111/J.1365-2133.2005.06607.X  0.39
2004 McNae IW, Fishburne K, Habtemariam A, Hunter TM, Melchart M, Wang F, Walkinshaw MD, Sadler PJ. Half-sandwich arene ruthenium(II)-enzyme complex. Chemical Communications (Cambridge, England). 1786-7. PMID 15306883 DOI: 10.1039/B408141B  0.376
2004 Zhong W, Parkinson JA, Parsons S, Oswald ID, Coxall RA, Sadler PJ. Structure and dynamics of dinuclear zirconium(IV) complexes. Inorganic Chemistry. 43: 3561-72. PMID 15180408 DOI: 10.1021/Ic049932K  0.36
2004 Hunter TM, Paisey SJ, Park HS, Cleghorn L, Parkin A, Parsons S, Sadler PJ. Configurations of metallocyclams and relevance to anti-HIV activity. Journal of Inorganic Biochemistry. 98: 713-9. PMID 15134916 DOI: 10.1016/J.Jinorgbio.2003.10.018  0.394
2004 Liang X, Sadler PJ. Cyclam complexes and their applications in medicine. Chemical Society Reviews. 33: 246-66. PMID 15103406 DOI: 10.1039/B313659K  0.313
2004 Pizarro AM, Munk VP, Navarro-Ranninger C, Sadler PJ. Hydrolysis triggers oxidation of a trans diamine platinum(II) anticancer complex. Angewandte Chemie (International Ed. in English). 42: 5339-42. PMID 14613170 DOI: 10.1002/Anie.200352303  0.36
2003 Wang F, Chen H, Parsons S, Oswald ID, Davidson JE, Sadler PJ. Kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 5810-20. PMID 14673852 DOI: 10.1002/Chem.200304724  0.371
2003 Chen H, Parkinson JA, Nováková O, Bella J, Wang F, Dawson A, Gould R, Parsons S, Brabec V, Sadler PJ. Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Proceedings of the National Academy of Sciences of the United States of America. 100: 14623-8. PMID 14657383 DOI: 10.1073/Pnas.2434016100  0.383
2003 Liang X, Weishäupl M, Parkinson JA, Parsons S, McGregor PA, Sadler PJ. Selective recognition of configurational substates of zinc cyclam by carboxylates: implications for the design and mechanism of action of anti-HIV agents. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 4709-17. PMID 14566877 DOI: 10.1002/Chem.200304808  0.391
2003 Novakova O, Chen H, Vrana O, Rodger A, Sadler PJ, Brabec V. DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media. Biochemistry. 42: 11544-54. PMID 14516206 DOI: 10.1021/Bi034933U  0.379
2003 Kaspárková J, Mackay FS, Brabec V, Sadler PJ. Formation of platinated GG cross-links on DNA by photoactivation of a platinum(IV) azide complex. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 8: 741-5. PMID 14505077 DOI: 10.1007/S00775-003-0474-3  0.38
2003 Stewart AJ, Blindauer CA, Berezenko S, Sleep D, Sadler PJ. Interdomain zinc site on human albumin. Proceedings of the National Academy of Sciences of the United States of America. 100: 3701-6. PMID 12598656 DOI: 10.1073/Pnas.0436576100  0.307
2003 Müller P, Schröder B, Parkinson JA, Kratochwil NA, Coxall RA, Parkin A, Parsons S, Sadler PJ. Nucleotide cross-linking induced by photoreactions of platinum(IV)-azide complexes. Angewandte Chemie (International Ed. in English). 42: 335-9. PMID 12548693 DOI: 10.1002/Anie.200390110  0.379
2003 Chen H, Parkinson JA, Morris RE, Sadler PJ. Highly selective binding of organometallic ruthenium ethylenediamine complexes to nucleic acids: novel recognition mechanisms. Journal of the American Chemical Society. 125: 173-86. PMID 12515520 DOI: 10.1021/Ja027719M  0.379
2003 Fernandez R, Melchart M, Van Der Geer E, Wang F, Habtemariam A, Sadler PJ. Ruthenium(II) arene anticancer complexes: selective recognition of nucleobases and control of hydrolysis rates Journal of Inorganic Biochemistry. 96: 130. DOI: 10.1016/S0162-0134(03)80612-8  0.329
2003 Chen H, Parkinson JA, Bella J, Dawson A, Gould RO, Parsons S, Sadler PJ. Chiral dinuclear bis Ru(η6-arene) anticancer complexes: Diastereoselectivity in guanine N7 recognition Journal of Inorganic Biochemistry. 96: 113. DOI: 10.1016/S0162-0134(03)80583-4  0.362
2003 Fakih S, Munk V, Shipman M, Murdoch P, Parkinson J, Sadler P. Novel Adducts of the Anticancer Drug Oxaliplatin with Glutathione and Redox Reactions with Glutathione Disulfide European Journal of Inorganic Chemistry. 2003: 1206-1214. DOI: 10.1002/Ejic.200390156  0.307
2002 Blindauer CA, Harrison MD, Robinson AK, Parkinson JA, Bowness PW, Sadler PJ, Robinson NJ. Multiple bacteria encode metallothioneins and SmtA-like zinc fingers. Molecular Microbiology. 45: 1421-32. PMID 12207707 DOI: 10.1046/J.1365-2958.2002.03109.X  0.3
2002 Liang X, Parkinson JA, Parsons S, Weishäupl M, Sadler PJ. Cadmium cyclam complexes: interconversion of cis and trans configurations and fixation of CO(2). Inorganic Chemistry. 41: 4539-47. PMID 12184772 DOI: 10.1021/Ic0255050  0.344
2002 Wang F, Chen H, Parkinson JA, Murdoch Pdel S, Sadler PJ. Reactions of a ruthenium(II) arene antitumor complex with cysteine and methionine. Inorganic Chemistry. 41: 4509-23. PMID 12184769 DOI: 10.1021/Ic025538F  0.33
2002 Liang X, Parkinson JA, Weishäupl M, Gould RO, Paisey SJ, Park HS, Hunter TM, Blindauer CA, Parsons S, Sadler PJ. Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society. 124: 9105-12. PMID 12149014 DOI: 10.1021/Ja0260723  0.363
2002 Aird RE, Cummings J, Ritchie AA, Muir M, Morris RE, Chen H, Sadler PJ, Jodrell DI. In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer. British Journal of Cancer. 86: 1652-7. PMID 12085218 DOI: 10.1038/Sj.Bjc.6600290  0.318
2002 Zhong W, Parkinson JA, Guo M, Sadler PJ. Unusual features for zirconium(IV) binding to human serum transferrin. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 7: 589-99. PMID 12072964 DOI: 10.1007/S00775-001-0337-8  0.323
2002 Chen H, Parkinson JA, Parsons S, Coxall RA, Gould RO, Sadler PJ. Organometallic ruthenium(II) diamine anticancer complexes: arene-nucleobase stacking and stereospecific hydrogen-bonding in guanine adducts. Journal of the American Chemical Society. 124: 3064-82. PMID 11902898 DOI: 10.1021/Ja017482E  0.39
2002 Djuran MI, Milinkovic SU, Habtemariam A, Parsons S, Sadler PJ. Crystal packing and hydrogen bonding in platinum(II) nucleotide complexes: X-ray crystal structure of [Pt(MeSCH(2)CH(2)SMe)(5'-GMP-N7)(2)].6H(2)O. Journal of Inorganic Biochemistry. 88: 268-73. PMID 11897340 DOI: 10.1016/S0162-0134(01)00351-8  0.37
2002 Guo M, Guo Z, Sadler PJ. Titanium(IV) targets phosphoesters on nucleotides: implications for the mechanism of action of the anticancer drug titanocene dichloride. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 6: 698-707. PMID 11681703 DOI: 10.1007/S007750100248  0.329
2002 Morris R, Habtemariam A, Guo Z, Parsons S, Sadler PJ. Chelate ring-opening aminophosphine complexes of ruthenium(II) Inorganica Chimica Acta. 339: 551-559. DOI: 10.1016/S0020-1693(02)01133-7  0.407
2002 Bihari S, Smith PA, Parsons S, Sadler PJ. Stereoisomers of Mn(III) complexes of ethylenebis[(o-hydroxyphenyl)glycine] Inorganica Chimica Acta. 331: 310-317. DOI: 10.1016/S0020-1693(02)00690-4  0.308
2001 Morris RE, Aird RE, Murdoch Pdel S, Chen H, Cummings J, Hughes ND, Parsons S, Parkin A, Boyd G, Jodrell DI, Sadler PJ. Inhibition of cancer cell growth by ruthenium(II) arene complexes. Journal of Medicinal Chemistry. 44: 3616-21. PMID 11606126 DOI: 10.1021/Jm010051M  0.437
2001 Blindauer CA, Harrison MD, Parkinson JA, Robinson AK, Cavet JS, Robinson NJ, Sadler PJ. A metallothionein containing a zinc finger within a four-metal cluster protects a bacterium from zinc toxicity. Proceedings of the National Academy of Sciences of the United States of America. 98: 9593-8. PMID 11493688 DOI: 10.1073/Pnas.171120098  0.32
2001 Habtemariam A, Watchman B, Potter BS, Palmer R, Parsons S, Parkin A, Sadler PJ. Control of aminophosphine chelate ring-opening in Pt(II) and Pd(II) complexes: potential dual-mode anticancer agents Journal of the Chemical Society-Dalton Transactions. 1306-1318. DOI: 10.1039/B009117K  0.357
2001 Habtemariam A, Parkinson JA, Margiotta N, Hambley TW, Parsons S, Sadler PJ. Structure and dynamics of a platinum(II) aminophosphine complex and its nucleobase adducts Journal of the Chemical Society, Dalton Transactions. 362-372. DOI: 10.1039/B007670H  0.383
2000 Guo M, Sun H, Bihari S, Parkinson JA, Gould RO, Parsons S, Sadler PJ. Stereoselective formation of seven-coordinate titanium(IV) monomer and dimer complexes of ethylenebis(o-hydroxyphenyl)glycine. Inorganic Chemistry. 39: 206-15. PMID 11272527 DOI: 10.1021/Ic990669A  0.355
2000 Guo M, Sun H, McArdle HJ, Gambling L, Sadler PJ. TiIV Uptake and Release by Human Serum Transferrin and Recognition of TiIV-Transferrin by Cancer Cells: Understanding the Mechanism of Action of the Anticancer Drug Titanocene Dichloride† Biochemistry. 39: 10023-10033. PMID 10955990 DOI: 10.1021/Bi000798Z  0.322
2000 Sevillano P, Habtemariam A, Seijo MIG, Castiñeiras A, Parsons S, García ME, Sadler PJ. Homonuclear PdII and PtII and heteronuclear PdII-AuI and PtII-AuI complexes of a tripod triphosphine ligand: synthesis, characterization and reactions with molecules of biological relevance Australian Journal of Chemistry. 53: 635. DOI: 10.1071/Ch00028  0.402
1999 Kratochwil NA, Parkinson JA, Bednarski PJ, Sadler PJ. Nucleotide Platination Induced by Visible Light. Angewandte Chemie (International Ed. in English). 38: 1460-1463. PMID 29711587 DOI: 10.1002/(Sici)1521-3773(19990517)38:10<1460::Aid-Anie1460>3.0.Co;2-Z  0.359
1999 Guo Z, Sadler PJ. Metals in Medicine. Angewandte Chemie (International Ed. in English). 38: 1512-1531. PMID 29711002 DOI: 10.1002/(Sici)1521-3773(19990601)38:11<1512::Aid-Anie1512>3.0.Co;2-Y  0.345
1999 Cox MC, Barnham KJ, Frenkiel TA, Hoeschele JD, Mason AB, He QY, Woodworth RC, Sadler PJ. Identification of platination sites on human serum transferrin using (13)C and (15)N NMR spectroscopy. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 4: 621-31. PMID 10550692 DOI: 10.1007/S007750050386  0.362
1999 del Socorro Murdoch P, Kratochwil NA, Parkinson JA, Patriarca M, Sadler PJ. A Novel Dinuclear Diaminoplatinum(II) Glutathione Macrochelate. Angewandte Chemie (International Ed. in English). 38: 2949-2951. PMID 10540403 DOI: 10.1002/(Sici)1521-3773(19991004)38:19<2949::Aid-Anie2949>3.0.Co;2-Q  0.365
1999 Sun H, Li H, Harvey I, Sadler PJ. Interactions of bismuth complexes with metallothionein(II). The Journal of Biological Chemistry. 274: 29094-101. PMID 10506163 DOI: 10.1074/Jbc.274.41.29094  0.379
1999 Murdoch Pdel S, Guo Z, Parkinson JA, Sadler PJ. Kinetics of formation and stability of [Pt(dien)]2+ complexes with octamer and 14-mer DNA oligonucleotides containing a GG sequence. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 4: 32-8. PMID 10499100 DOI: 10.1007/S007750050286  0.313
1999 Neplechová K, Kaspárková J, Vrána O, Nováková O, Habtemariam A, Watchman B, Sadler PJ, Brabec V. DNA interactions of new antitumor aminophosphine platinum(II) complexes. Molecular Pharmacology. 56: 20-30. PMID 10385680 DOI: 10.1124/Mol.56.1.20  0.342
1999 Barton SJ, Barnham KJ, Habtemariam A, Frey U, Sue RE, Sadler PJ. [1H,15N] N.M.R. Kinetic Studies of Reactions of cis- and trans-[PtCl2(15NH3)(c-C6H1115NH2)] with Guanosine 5'-Monophosphate Australian Journal of Chemistry. 52: 173. DOI: 10.1071/C98168  0.337
1999 Sevillano P, Habtemariam A, Parsons S, Castiñeiras A, García ME, Sadler PJ. Gold( I )-induced chelate ring-opening of palladium( II ) and platinum( II ) triphos complexes Journal of the Chemical Society-Dalton Transactions. 2861-2870. DOI: 10.1039/A903775F  0.399
1999 Patriarca M, Kratchowil NA, Sadler PJ. Simultaneous determination of Pt and I by ICP-MS for studies of the mechanism of reaction of diiodoplatinum anticancer complexes Journal of Analytical Atomic Spectrometry. 14: 633-637. DOI: 10.1039/A807981A  0.321
1999 Kratochwil NA, Ivanov AI, Patriarca M, Parkinson JA, Gouldsworthy AM, del Socorro Murdoch P, Sadler PJ. Surprising Reactions of Iodo Pt(IV) and Pt(II) Complexes with Human Albumin:  Detection of Cys34 Sulfenic Acid Journal of the American Chemical Society. 121: 8193-8203. DOI: 10.1021/Ja990768N  0.338
1999 Guo Z, Sadler PJ. Medicinal Inorganic Chemistry Advances in Inorganic Chemistry. 49: 183-306. DOI: 10.1016/S0898-8838(08)60271-8  0.368
1999 Sadler PJ, Li H, Sun H. Coordination chemistry of metals in medicine: target sites for bismuth Coordination Chemistry Reviews. 185: 689-709. DOI: 10.1016/S0010-8545(99)00018-1  0.342
1999 Chen Y, Parkinson JA, Guo Z, Brown T, Sadler PJ. A New Platinum Anticancer Drug Forms a Highly Stereoselective Adduct with Duplex DNA Angewandte Chemie International Edition. 38: 2060-2063. DOI: 10.1002/(Sici)1521-3773(19990712)38:13/14<2060::Aid-Anie2060>3.0.Co;2-J  0.3
1998 Sun H, Li H, Weir RA, Sadler PJ. The First Specific Ti -Protein Complex: Potential Relevance to Anticancer Activity of Titanocenes. Angewandte Chemie (International Ed. in English). 37: 1577-1579. PMID 29710917 DOI: 10.1002/(Sici)1521-3773(19980619)37:11<1577::Aid-Anie1577>3.0.Co;2-M  0.585
1998 Ivanov AI, Christodoulou J, Parkinson JA, Barnham KJ, Tucker A, Woodrow J, Sadler PJ. Cisplatin binding sites on human albumin. The Journal of Biological Chemistry. 273: 14721-30. PMID 9614070 DOI: 10.1074/Jbc.273.24.14721  0.374
1998 SUN H, LI H, MASON AB, WOODWORTH RC, SADLER PJ. N-lobe versus C-lobe complexation of bismuth by human transferrin Biochemical Journal. 337: 105-111. DOI: 10.1042/Bj3370105  0.326
1998 Chen Y, Guo Z, Parkinson JA, Sadler PJ. Kinetic control of reactions of a sterically hindered platinum picoline anticancer complex with guanosine 5′-monophosphate and glutathione Journal of the Chemical Society-Dalton Transactions. 3577-3586. DOI: 10.1039/A806544F  0.391
1998 Fritsky IO, Kozłowski H, Sadler PJ, Yefetova OP, Śwątek-Kozłowska J, Kalibabchuk VA, Głowiak T. Template synthesis of square-planar nickel(II) and copper(III) complexes based on hydrazide ligands Journal of the Chemical Society-Dalton Transactions. 3269-3274. DOI: 10.1039/A802451K  0.386
1998 Chen Y, Guo Z, Murdoch PdS, Zang E, Sadler PJ. Interconversion between S- and N-bound L-methionine adducts of Pt(dien)2+ (dien = diethylenetriamine) via dien ring-opened intermediates Journal of the Chemical Society-Dalton Transactions. 1503-1508. DOI: 10.1039/A709282B  0.335
1998 Parkinson JA, Sun H, Sadler PJ. New approach to the solution chemistry of bismuth citrate antiulcer complexes Chemical Communications. 881-882. DOI: 10.1039/A708710A  0.348
1998 Guo Z, Habtemariam A, Sadler PJ, Palmer R, Potter BS. Conformational flexibility within the chelate rings of [Pt(en)(CBDCA-O,O′)], an analogue of the antitumour drug carboplatin: X-ray crystallographic and solid-state NMR studies New Journal of Chemistry. 22: 11-14. DOI: 10.1039/A706739I  0.346
1998 Kratochwil NA, Guo Z, del Socorro Murdoch P, Parkinson JA, Bednarski PJ, Sadler PJ. Electron-Transfer-Driven Trans-Ligand Labilization:  A Novel Activation Mechanism for Pt(IV) Anticancer Complexes Journal of the American Chemical Society. 120: 8253-8254. DOI: 10.1021/Ja980393Q  0.361
1998 Davis JJ, Green ML, Allen O. Hill H, Leung YC, Sadler PJ, Sloan J, Xavier AV, Chi Tsang S. The immobilisation of proteins in carbon nanotubes Inorganica Chimica Acta. 272: 261-266. DOI: 10.1016/S0020-1693(97)05926-4  0.521
1998 Barton SJ, Barnham KJ, Habtemariam A, Sue RE, Sadler PJ. pKa values of aqua ligands of platinum(II) anticancer complexes: [1H, 15N and 195Pt NMR studies of cis- and trans-[PtCl2(NH3)(cyclohexylamine) Inorganica Chimica Acta. 273: 8-13. DOI: 10.1016/S0020-1693(97)05912-4  0.372
1998 Guo Z, Habtemariam A, Sadler PJ, James BR. Chelate ring-opening ruthenium complexes: X-ray crystal structure and solution studies of cis, trans-bis(2-dimethyl-aminoethyl)-diphenyl-phosphino(dichloro)ruthenium(II) Inorganica Chimica Acta. 273: 1-7. DOI: 10.1016/S0020-1693(97)05911-2  0.551
1998 Chen Y, Guo Z, Parsons S, Sadler PJ. Stereospecific and Kinetic Control over the Hydrolysis of a Sterically Hindered Platinum Picoline Anticancer Complex Chemistry - a European Journal. 4: 672-676. DOI: 10.1002/(Sici)1521-3765(19980416)4:4<672::Aid-Chem672>3.0.Co;2-8  0.397
1997 Reeder F, Guo Z, Murdoch PDS, Corazza A, Hambley TW, Berners-Price SJ, Chottard JC, Sadler PJ. Platination of a GG site on single-stranded and double-stranded forms of a 14-base oligonucleotide with diaqua cisplatin followed by NMR and HPLC. Influence of the platinum ligands and base sequence on 5'-G versus 3'-G platination selectivity European Journal of Biochemistry. 249: 370-382. PMID 9370343 DOI: 10.1111/J.1432-1033.1997.00370.X  0.318
1997 Sadler P. Metal complexes in medicine: Design and mechanism of action Journal of Inorganic Biochemistry. 67: 4. DOI: 10.1351/Pac199870040863  0.331
1997 Guo Z, Chen Y, Zang E, Sadler PJ. [1H,15N] Nuclear magnetic resonance studies of [Pt(dien)Cl]+ (dien = diethylenetriamine): hydrolysis and reactions with nucleotides‡ Journal of the Chemical Society-Dalton Transactions. 4107-4112. DOI: 10.1039/A704585I  0.401
1997 Balestrieri E, Bellugi L, Boicelli A, Giomini M, Giuliani AM, Giustini M, Marciani L, Sadler PJ. Interaction of tin( IV ) with doxorubicin Journal of the Chemical Society-Dalton Transactions. 4099-4106. DOI: 10.1039/A702588B  0.33
1997 Best SL, Chattopadhyay TK, Djuran MI, Palmer RA, Sadler PJ, Sóvágó I, Varnagy K. Gold(III) and palladium(II) complexes ofglycylglycyl-L-histidine: crystal structures of[AuIII(Gly-Gly-L-His-H-2)]Cl·H2O and[PdII(Gly-Gly-L-His-H-2)]·1.5H2O and HisεNH deprotonation Journal of the Chemical Society-Dalton Transactions. 2587-2596. DOI: 10.1039/A701395G  0.339
1997 Guo Z, Sadler PJ, Zang E. Recognition of platinum(ii) amine complexes by nucleotides: roleofphosphate and carbonyl groups in([15N3]diethylenetriamine)-(guanosine5′-monophosphate)platinum(ii) Chemical Communications. 27-28. DOI: 10.1039/A606275J  0.354
1997 Guo Z, Hambley TW, Murdoch PdS, Sadler PJ, Frey U. Chelate-ring-opened adducts of[Pt(en)(Me-Mal-O,O′)](en = ethane-1,2-diamine,Me-Mal = 2-methylmalonate) with methionine derivatives:relevance to the biological activity of platinum anticanceragents Journal of the Chemical Society-Dalton Transactions. 469-478. DOI: 10.1039/A604210D  0.339
1997 Habtemariam A, Neplechova K, Brabec V, Margiotta N, Sadler P. Unusual DNA binding properties of chelate ring-opening platinum complexes Journal of Inorganic Biochemistry. 67: 161. DOI: 10.1016/S0162-0134(97)80039-6  0.327
1997 Sun H, Li H, Sadler PJ. The Biological and Medicinal Chemistry of Bismuth Chemische Berichte. 130: 669-681. DOI: 10.1002/Cber.19971300602  0.338
1997 Tsang SC, Guo Z, Chen YK, Green MLH, Hill HAO, Hambley TW, Sadler PJ. Immobilization of Platinated and Iodinated Oligonucleotides on Carbon Nanotubes Angewandte Chemie International Edition in English. 36: 2198-2200. DOI: 10.1002/Anie.199721981  0.581
1997 Margiotta N, Habtemariam A, Sadler PJ. Strong, Rapid Binding of a Platinum Complex to Thymine and Uracil Under Physiological Conditions Angewandte Chemie International Edition in English. 36: 1185-1187. DOI: 10.1002/Anie.199711851  0.332
1997 Tsang SC, Guo Z, Chen YK, Green MLH, Hill HAO, Hambley TW, Sadler PJ. Immobilisierung von platinierten und iodierten DNA-Oligomeren an Kohlenstoff-Nanoröhren Angewandte Chemie. 109: 2291-2294. DOI: 10.1002/Ange.19971092009  0.596
1996 Beatty EJ, Cox MC, Frenkiel TA, Tam BM, Mason AB, MacGillivray RT, Sadler PJ, Woodworth RC. Interlobe communication in 13C-methionine-labeled human transferrin. Biochemistry. 35: 7635-42. PMID 8672464 DOI: 10.1021/Bi960684G  0.301
1996 Corazza A, Harvey I, Sadler PJ. 1H,13C-NMR and X-ray absorption studies of copper(I) glutathione complexes. European Journal of Biochemistry / Febs. 236: 697-705. PMID 8612647 DOI: 10.1111/J.1432-1033.1996.0697D.X  0.302
1996 Li H, Sadler PJ, Sun H. Unexpectedly Strong Binding of a Large Metal Ion (Bi) to Human Serum Transferrin Journal of Biological Chemistry. 271: 9483-9489. DOI: 10.1074/Jbc.271.16.9483  0.316
1996 Barnham KJ, Guo Z, Sadler PJ. Stabilization of monofunctional platinum–nucleotide adducts: reactions of N-acetyl-L-methionine complexes with guanosine 5′-monophosphate and guanylyl(3′–5′)guanosine Journal of the Chemical Society-Dalton Transactions. 2867-2876. DOI: 10.1039/Dt9960002867  0.368
1996 Barrie PJ, Djuran MI, Mazid MA, McPartlin M, Sadler PJ, Scowen IJ, Sun H. Solid-state carbon-13 nuclear magnetic resonance investigations of bismuth citrate complexes and crystal structure of Na2[Bi2(cit)2]·7H2O Journal of the Chemical Society-Dalton Transactions. 2417-2422. DOI: 10.1039/Dt9960002417  0.367
1996 Habtemariam A, Sadler PJ. Design of chelate ring-opening platinum anticancer complexes: reversible binding to guanine Chemical Communications. 1785-1786. DOI: 10.1039/Cc9960001785  0.373
1996 Bal W, Chmurny GN, Hilton BD, Sadler PJ, Tucker A. Axial Hydrophobic Fence in Highly-Stable Ni(II) Complex of Des-Angiotensinogen N-Terminal Peptide Journal of the American Chemical Society. 118: 4727-4728. DOI: 10.1021/Ja953988J  0.323
1996 Berners-Price SJ, Sadler PJ. Coordination chemistry of metallodrugs: insights into biological speciation from NMR spectroscopy Coordination Chemistry Reviews. 151: 1-40. DOI: 10.1016/S0010-8545(96)90191-5  0.365
1996 Sadler PJ, Sun H, Li H. Bismuth(III) Complexes of the Tripeptide Glutathione (γ-L-Glu–L-Cys–Gly) Chemistry - a European Journal. 2: 701-708. DOI: 10.1002/Chem.19960020615  0.326
1995 Berners-Price SJ, Collier DC, Mazid MA, Sadler PJ, Sue RE, Wilkie D. [Ag(I)(Et(2)PCH(2)CH(2)PPh(2))(2)]NO(3): An Antimitochondrial Silver Complex. Metal-Based Drugs. 2: 111-22. PMID 18472753 DOI: 10.1155/Mbd.1995.111  0.313
1995 Barnham KJ, Djuran MI, Murdoch PdS, Ranford JD, Sadler PJ. L-Methionine increases the rate of reaction of 5′-guanosine monophosphate with the anticancer drug cisplatin: mixed-ligand adducts and reversible methionine binding Journal of the Chemical Society-Dalton Transactions. 3721-3726. DOI: 10.1039/Dt9950003721  0.325
1995 Sadler PJ, Sun H. Ranitidine bismuth(III) citrate Journal of the Chemical Society-Dalton Transactions. 1395-1401. DOI: 10.1039/Dt9950001395  0.358
1995 Sun H, Li H, Sadler PJ. Complexation of bismuth(III) by glutathione in aqueous solution and intact red blood cells Journal of Inorganic Biochemistry. 59: 190. DOI: 10.1016/0162-0134(95)97296-3  0.322
1995 Corazza A, Harvey I, Sadler PJ. Solution studies of copper(I) glutathione complexes Journal of Inorganic Biochemistry. 59: 123. DOI: 10.1016/0162-0134(95)97233-G  0.312
1994 Berners-Price SJ, Collier DC, Sadler PJ, Sue RE, Wilkie D. Silver diphosphine complexes as antimitochondrial agents. Metal-Based Drugs. 1: 523. PMID 18476281 DOI: 10.1155/Mbd.1994.523  0.337
1994 Christodoulou J, Sadler PJ, Tucker A. A new structural transition of serum albumin dependent on the state of Cys34. Detection by 1H-NMR spectroscopy. European Journal of Biochemistry. 225: 363-8. PMID 7925457 DOI: 10.1111/J.1432-1033.1994.00363.X  0.321
1994 Dhubhghaill OMN, Hagen WR, Keppler BK, Lipponer K, Sadler PJ. Aquation of the anticancer complex trans-[RuCl4(Him)2]–(Him = imidazole) Journal of the Chemical Society-Dalton Transactions. 3305-3310. DOI: 10.1039/Dt9940003305  0.323
1994 Barnham KJ, Djuran MI, Murdoch PdS, Sadler PJ. Intermolecular displacement of S-bound L-methionine on platinum(II) by guanosine 5′-monophosphate: implications for the mechanism of action of anticancer drugs Journal of the Chemical Society, Chemical Communications. 721-722. DOI: 10.1039/C39940000721  0.309
1994 Barnham KJ, Frey U, Murdoch PdS, Ranford JD, Sadler PJ, Newell DR. [Pt(CBDCA-O)(NH3)2(L-Methionine-S)]: Ring-Opened Adduct of the Anticancer Drug Carboplatin ("Paraplatin"). Detection of a Similar Complex in Urine by NMR Spectroscopy Journal of the American Chemical Society. 116: 11175-11176. DOI: 10.1021/Ja00103A050  0.334
1994 Berners-Price SJ, Ranford JD, Sadler PJ. [1H, 15N] NMR Investigations of Pt-NH Hydrogen Bonding in d(GpG), d(pGpG), and d(TpGpG)-N7,N7 Adducts of [Pt(en)]2+ in Aqueous Solution Inorganic Chemistry. 33: 5842-5846. DOI: 10.1021/Ic00103A036  0.309
1994 Bligh S, Harding CT, McEwen AB, Sadler PJ, Kelly J, Marriott JA. Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents Polyhedron. 13: 1937-1943. DOI: 10.1016/0277-5387(94)80018-9  0.38
1993 Ranford JD, Sadler PJ, Tocher DA. Cytotoxicity and antiviral activity of transition-metal salicylato complexes and crystal structure of Bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II) Journal of the Chemical Society, Dalton Transactions. 3393-3399. DOI: 10.1039/Dt9930003393  0.357
1993 Jarrett PS, Dhubhghaill OMN, Sadler PJ. Amphiphilic bis(thiolato)-nickel(II), -palladium(II) and -platinum(II) complexes with diphosphine or phosphinoarsine ligands Journal of the Chemical Society-Dalton Transactions. 1863-1870. DOI: 10.1039/Dt9930001863  0.361
1993 Patel SU, Sadler PJ, Tucker A, Viles JH. Direct detection of albumin in human blood plasma by proton NMR spectroscopy. Complexation of nickel2+ Journal of the American Chemical Society. 115: 9285-9286. DOI: 10.1021/Ja00073A053  0.312
1993 Berners-Price SJ, Frey U, Ranford JD, Sadler PJ. Stereospecific hydrogen-bonding in mononucleotide adducts of platinum anticancer complexes in aqueous solution Journal of the American Chemical Society. 115: 8649-8659. DOI: 10.1021/Ja00072A019  0.375
1993 Murdoch SdP, Ranford JD, Sadler PJ, Berners-Price SJ. Cis-trans isomerization of [bis(L-methioninato)platinum]: metabolite of the anticancer drug cisplatin Inorganic Chemistry. 32: 2249-2255. DOI: 10.1021/Ic00063A009  0.306
1993 Frey U, Ranford JD, Sadler PJ. Ring-opening reactions of the anticancer drug carboplatin: NMR characterization of cis-[Pt(NH3)2(CBDCA-O)(5'-GMP-N7)] in solution Inorganic Chemistry. 32: 1333-1340. DOI: 10.1021/Ic00060A005  0.331
1993 Sadler P. Metallothioneins. synthesis, structure and properties of metallothioneins, phytochelatins and metal-thiolate complexes Journal of Organometallic Chemistry. 460: C12. DOI: 10.1016/0022-328X(93)80374-K  0.325
1992 Bligh SW, Boyle HA, McEwen AB, Sadler PJ, Woodham RH. 1H NMR studies of reactions of copper complexes with human blood plasma and urine. Biochemical Pharmacology. 43: 137-45. PMID 1739401 DOI: 10.1016/0006-2952(92)90270-S  0.313
1992 Sadler PJ, Tucker A. Proton NMR studies of bovine serum albumin. Assignment of spin systems. European Journal of Biochemistry. 205: 631-43. PMID 1572363 DOI: 10.1111/J.1432-1033.1992.Tb16821.X  0.309
1992 Rhodes MD, Sadler PJ, Scawen MD, Silver S. Effects of gold(I) antiarthritic drugs and related compounds on Pseudomonas putida. Journal of Inorganic Biochemistry. 46: 129-42. PMID 1355789 DOI: 10.1016/0162-0134(92)80016-O  0.318
1992 Berners-Price SJ, Frenkiel TA, Ranford JD, Sadler PJ. Nuclear magnetic resonance studies of N–H bonds in platinum anticancer complexes: detection of reaction intermediates and hydrogen bonding in guanosine 5′-monophosphate adducts of [PtCl2(NH3)2] Journal of the Chemical Society-Dalton Transactions. 2137-2139. DOI: 10.1039/Dt9920002137  0.331
1992 Berners-Price SJ, Frenkiel TA, Frey U, Ranford JD, Sadler PJ. Hydrolysis products of cisplatin: pKa determinations via[1H, 15N] NMR spectroscopy Journal of the Chemical Society, Chemical Communications. 789-791. DOI: 10.1039/C39920000789  0.306
1992 Norman RE, Ranford JD, Sadler PJ. Studies of platinum(II) methionine complexes: metabolites of cisplatin Inorganic Chemistry. 31: 877-888. DOI: 10.1021/Ic00031A033  0.342
1991 Jarrett PS, Sadler PJ. Nickel(II) bis(phosphine) complexes Inorganic Chemistry. 30: 2098-2104. DOI: 10.1021/Ic00009A028  0.342
1991 MacDonald FM, Sadler PJ. Studies of the cis-trans isomerism of some square-planar platinum(II) nitroimidazole complexes Polyhedron. 10: 1443-1448. DOI: 10.1016/S0277-5387(00)81281-4  0.351
1991 Ranford JD, Sadler PJ, Tocher DA. The X-ray crystal structure and biological activity of 3,5-diisopropylsalicylato Cu(II) complexes Journal of Inorganic Biochemistry. 43: 623. DOI: 10.1016/0162-0134(91)84594-Y  0.315
1991 Ranford JD, Sadler PJ, Norman RE. Multinuclear NMR studies of Pt(II) methionine complexes: Metabolites of Cisplatin Journal of Inorganic Biochemistry. 43: 603. DOI: 10.1016/0162-0134(91)84574-S  0.373
1991 Macdonald FM, Sadler PJ. Multinuclear MR studies of Platinum(II) nitroimidazole complexes:15N-labelling and reactions with nucleotides Magnetic Resonance in Chemistry. 29: S52-S59. DOI: 10.1002/Mrc.1260291312  0.417
1990 Berners-Price SJ, Girard GR, Hill DT, Sutton BM, Jarrett PS, Faucette LF, Johnson RK, Mirabelli CK, Sadler PJ. Cytotoxicity and antitumor activity of some tetrahedral bis(diphosphino)gold(I) chelates. Journal of Medicinal Chemistry. 33: 1386-92. PMID 2329559 DOI: 10.1021/Jm00167A017  0.311
1990 Dhubhghaill OMN, Sadler PJ, Kuroda R. Gold(I) complexes of 1-diphenylarsino-2-diphenylphosphinoethane (dadpe): solution studies, X-ray crystal structures, and cytotoxicity of [(AuCl)2dadpe]·0.5dma (dma = dimethylacetamide) and [Au(dadpe)2]Cl·2H2O Journal of the Chemical Society-Dalton Transactions. 2913-2921. DOI: 10.1039/Dt9900002913  0.381
1989 Bligh SW, Drake AF, Sadler PJ. Ultraviolet and magnetic-circular-dichroic spectroscopic studies of Gd(III) complexed with diethylenetriaminepentaacetic acid. A contrast agent for NMR imaging. European Journal of Biochemistry. 181: 223-4. PMID 2714280 DOI: 10.1111/J.1432-1033.1989.Tb14714.X  0.32
1989 Dhubhghaill O, Sadler P, Kuroda R. Phosphino-arsino gold complexes: Structure, reactivity and cytotoxicity Journal of Inorganic Biochemistry. 36: 162. DOI: 10.1016/0162-0134(89)84053-X  0.353
1988 Berners-Price SJ, Sadler PJ. Interaction of the antitumor Au(I) complex [Au(Ph2P(CH2)2PPh2)2]Cl with human blood plasma, red cells, and lipoproteins: 31P and 1H NMR studies. Journal of Inorganic Biochemistry. 31: 267-81. PMID 3437279 DOI: 10.1016/0162-0134(87)80081-8  0.355
1987 Bell JD, Norman RE, Sadler PJ. Coordination chemistry in biological media: reactions of antitumor Pt(II) and Au(III) complexes with cell culture media Journal of Inorganic Biochemistry. 31: 241-246. PMID 3437278 DOI: 10.1016/0162-0134(87)80078-8  0.326
1987 Berners-Price SJ, Johnson RK, Mirabelli CK, Faucette LF, McCabe FL, Sadler PJ. Copper(I) complexes with bidentate tertiary phosphine ligands: solution chemistry and antitumor activity Inorganic Chemistry. 26: 3383-3387. DOI: 10.1021/Ic00267A034  0.313
1986 Graham GG, Bales JR, Grootveld MC, Sadler PJ. 1H, 13C NMR, and electronic absorption spectroscopic studies of the interaction of cyanide with aurothiomalate. Journal of Inorganic Biochemistry. 25: 163-73. PMID 3934340 DOI: 10.1016/0162-0134(85)80010-6  0.399
1986 Berners-Price SJ, Sadler PJ. Gold(I) complexes with bidentate tertiary phosphine ligands: formation of annular vs. tetrahedral chelated complexes Inorganic Chemistry. 25: 3822-3827. DOI: 10.1021/Ic00241A023  0.383
1986 Price SJB, Brevard C, Pagelot A, Sadler PJ. Bis((diphenylphosphino)(diethylphosphino)ethane)copper(1+) chloride: a chelated copper(I) complex with tetrahedral stereochemistry. Rate of inversion compared with those of isostructural silver(I) and gold(I) complexes Inorganic Chemistry. 25: 596-599. DOI: 10.1021/Ic00225A004  0.348
1985 Kuroda R, Ismail IM, Sadler PJ. X-ray and NMR studies of trans-dihydroxo-platinum(IV) antitumor complexes. Journal of Inorganic Biochemistry. 22: 103-17. PMID 6542127 DOI: 10.1016/0162-0134(84)80019-7  0.375
1985 Bales JR, Mazid MA, Sadler PJ, Aggarwal A, Kuroda R, Neidle S, Gilmour DW, Peart BJ, Ramsden CA. Platinum(II) complexes of nitroimidazoles: synthesis, characterisation, and X-ray crystal structures of cis-dichlorobis[1-(2′-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole]platinum(II) and trans-dichlorobis[1-(2′-hydroxy-3′-methoxypropyl)-2-nitroimidazole]platinum(II) Journal of the Chemical Society-Dalton Transactions. 795-802. DOI: 10.1039/Dt9850000795  0.39
1985 Price SJB, Brevard C, Pagelot A, Sadler PJ. Stable, chelated tetrahedral bis(phosphine) silver(I) complexes. A novel application of INEPT to silver-109{phosphorus-31} NMR Inorganic Chemistry. 24: 4278-4281. DOI: 10.1021/Ic00219A015  0.383
1985 Kerrison SS, Sadler PJ. 195Pt NMR studies of platinum(II) dimethylsuphoxide complexes Inorganica Chimica Acta. 104: 197-201. DOI: 10.1016/S0020-1693(00)86771-7  0.39
1985 Price SJB, DiMartino MJ, Hill DT, Kuroda R, Mazid MA, Sadler PJ. Tertiary phosphine complexes of gold(I) and gold(III) with imido ligands: 1H, 31P, and 15N NMR spectroscopy, antiinflammatory activity, and x-ray crystal structure of (phthalimido)(triethylphosphine)gold(I) Inorganic Chemistry. 24: 3425-3434. DOI: 10.1002/Chin.198605283  0.382
1985 BALES JR, MAZID MA, SADLER PJ, AGGARWAL A, KURODA R, NEIDLE S, GILMOUR DW, PEART BJ, RAMSDEN CA. ChemInform Abstract: PLATINUM(II) COMPLEXES OF NITROIMIDAZOLES: SYNTHESIS, CHARACTERIZATION, AND X-RAY CRYSTAL STRUCTURES OF CIS-DICHLOROBIS(1-(2′-HYDROXYETHYL)-2-HYDROXYMETHYL-5-NITROIMIDAZOLE)PLATINUM(II) AND TRANS-DICHLOROBIS(1-(2′-HYDROXY-3′-METHOXYPR Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198532336  0.35
1984 Berners-Price SJ, Mazid MA, Sadler PJ. Stable gold(I) complexes with chelate rings: solution studies of bis(phosphino)ethane complexes and X-ray crystal structure of bis[1,2-bis(diphenylphosphino)ethane]gold(I) hexafluoroantimonate–acetone (1/1) Journal of the Chemical Society-Dalton Transactions. 969-974. DOI: 10.1039/Dt9840000969  0.375
1984 BERNERS-PRICE SJ, MAZID MA, SADLER PJ. ChemInform Abstract: STABLE GOLD(I) COMPLEXES WITH CHELATE RINGS: SOLUTION STUDIES OF BIS(PHOSPHINO)ETHANE COMPLEXES AND X-RAY CRYSTAL STRUCTURE OF BIS(1,2-BIS(DIPHENYLPHOSPHINO)ETHANE)GOLD(I) HEXAFLUOROANTIMONATE-ACETONE (1/1) Chemischer Informationsdienst. 15. DOI: 10.1002/Chin.198435297  0.364
1983 Bales JR, Sadler PJ, Coulson CJ, Laverick M, Nias AH. Hypoxic cell sensitization to radiation damage by a new radiosensitizer: cis-dichloro-bis(1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole-N3)platinum(II) (flap). British Journal of Cancer. 46: 701-5. PMID 6890846 DOI: 10.1038/Bjc.1982.261  0.366
1983 Kuroda R, Neidle S, Ismail IM, Sadler PJ. X-Ray crystal and molecular structure of cis(NN′), trans(OO′)-bis-(2-aminoethanolato)-cis-dichloroplatinum(IV) dihydrate. The relationship of anti-tumour activity to ring closure Journal of the Chemical Society-Dalton Transactions. 823-825. DOI: 10.1039/Dt9830000823  0.346
1983 Bales JR, Coulson CJ, Gilmour DW, Mazid MA, Neidle S, Kuroda R, Peart BJ, Ramsden CA, Sadler PJ. The preparation and isomerization of platinum metronidazole complexes: X-ray crystal and molecular structures of cis- and trans-dichlorobis[1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole]-platinum(II) Journal of the Chemical Society, Chemical Communications. 432-433. DOI: 10.1039/C39830000432  0.371
1983 Grootveld MC, Sadler PJ. Differences between the structure of the anti-arthritic gold drug “myocrisin” in the solid state and in solution: a kinetic study of dissolution Journal of Inorganic Biochemistry. 19: 51-64. DOI: 10.1016/0162-0134(83)85012-0  0.301
1983 Hill DT, Sutton BM, Isab AA, Razi MT, Sadler PJ, Trooster JM, Calis GHM. Gold-197 Moessbauer studies of some gold(I) thiolates and their phosphine complexes including certain antiarthritic gold drugs Inorganic Chemistry. 22: 2936-2942. DOI: 10.1002/Chin.198401053  0.313
1982 Kerrison SJS, Sadler PJ. The trans influence in platinum chemistry. A platinum-195 nuclear magnetic resonance study of [15N]nitrito-, chloro-, and bromo-platinum-(II) and -(IV) complexes Journal of the Chemical Society-Dalton Transactions. 2363-2369. DOI: 10.1039/Dt9820002363  0.405
1982 Ismail IM, Kerrison SS, Sadler PJ. Effects of chemical shift anisotropy and 14N coupling on the 1H and 195Pt nuclear magnetic resonance spectra of platinum complexes Polyhedron. 1: 57-59. DOI: 10.1016/S0277-5387(00)81069-4  0.332
1981 Kerrison SJS, Sadler PJ. Co-ordination of amides to cis-[PtII(NH3)2(H2O)2]2+ Journal of the Chemical Society, Chemical Communications. 61-62. DOI: 10.1039/C39810000061  0.3
1980 Malik NA, Otiko G, Sadler PJ. Control of intra- and extra-cellular sulphydryl-disulphide balances with gold phosphine drugs: 31P nuclear magnetic resonance studies of human blood. Journal of Inorganic Biochemistry. 12: 317-22. PMID 7411141 DOI: 10.1016/S0162-0134(00)80272-X  0.348
1980 Ismail IM, Kerrison SJS, Sadler PJ. Chlorine and bromine isotope shifts in 195Pt n.m.r. spectra Journal of the Chemical Society, Chemical Communications. 1175-1176. DOI: 10.1039/C39800001175  0.325
1980 Pinto MAFDR, Sadler PJ, Neidle S, Sanderson MR, Subbiah A, Kuroda R. A novel di-platinum(II) octaphosphite complex showing metal–metal bonding and intense luminescence; a potential probe for basic proteins. X-Ray crystal and molecular structure Journal of the Chemical Society, Chemical Communications. 13-15. DOI: 10.1039/C39800000013  0.365
1980 Neidle S, Ismail IM, Sadler PJ. The structure of the antitumor complex cis-(diammino) (1,1-cyclobutanedicarboxylato)-Pt(II): X ray and nmr studies Journal of Inorganic Biochemistry. 13: 205-212. DOI: 10.1016/S0162-0134(00)80069-0  0.391
1980 Al-Najjar IM, Green M, Sarhan JK, Ismail IM, Sadler PJ. Multinuclear N.M.R. studies on cyclic platinum complexes Inorganica Chimica Acta. 44: L187-L188. DOI: 10.1016/S0020-1693(00)90999-X  0.303
1979 Al-Najjar IM, Green M, Kerrison SJS, Sadler PJ. Platinum complex containing a four-membered ring Journal of the Chemical Society, Chemical Communications. 311-312. DOI: 10.1039/C39790000311  0.368
1978 Malik NA, Sadler PJ, Neidle S, Taylor GL. X-Ray crystal structure of sodium bis(N-methylhydantoinato)gold(I) tetrahydrate; a linear, planar complex of pharmacological interest stabilised by two nitrogen ligands Journal of the Chemical Society, Chemical Communications. 711-712. DOI: 10.1039/C39780000711  0.382
1978 John S, Kerrison S, Sadler PJ. The convention for referencing platinum-195 NMR shifts and the cooperative shift effect for chloro-bromo complexes of Pt(IV) and Pt(II) Journal of Magnetic Resonance (1969). 31: 321-325. DOI: 10.1016/0022-2364(78)90195-6  0.347
1977 Isab AA, Sadler PJ. Reactions of gold(III) ions with ribonuclease A and methionine derivatives in aqueous solution. Biochimica Et Biophysica Acta. 492: 322-30. PMID 884133 DOI: 10.1016/0005-2795(77)90083-6  0.333
1977 Kerrison SJS, Sadler PJ. Solvolysis of cis-[Pt(NH3)2Cl2] in dimethyl sulphoxide and reactions of glycine with [PtCl3(Me2SO)]– as probed by 195Pt nuclear magnetic resonance shifts and 195Pt–15N coupling constants Journal of the Chemical Society, Chemical Communications. 861-863. DOI: 10.1039/C39770000861  0.302
1976 Ford L, Hill HA, Mann BE, Sadler PJ, Williams RJ. Nuclear magnetic resonance spectroscopy of cobalt(II) porphyrin-quinone complexes. Biochimica Et Biophysica Acta. 430: 413-8. PMID 938641 DOI: 10.1016/0005-2728(76)90016-5  0.74
1973 Barry CD, Hill HA, Mann BE, Sadler PJ, Williams RJ. Molecular structures of porphyrin complexes in solution. An 1H nuclear magnetic resonance spectroscopic investigation of the interaction between 2,4,7-trinitrofluorenone and nickel(II) and cobalt(II) mesoporphyrin IX dimethyl esters. Journal of the American Chemical Society. 95: 4545-51. PMID 4730662 DOI: 10.1021/Ja00795A014  0.737
1973 Barry CD, Hill HAO, Sadler PJ, Williams RJP. A magnetic resonance study of metal- porphyrin/caffeine complexes Proceedings of the Royal Society a: Mathematical, Physical and Engineering Sciences. 334: 493-504. DOI: 10.1098/Rspa.1973.0105  0.33
1973 Hill HAO, Horsler ADJ, Sadler PJ. 1 H nuclear magnetic resonance investigation of the formation of molecular salicylideneiminato-cobalt(II), -nickel(II), -copper(II), and -zinc(II) complexes with 1,3,5-trinitrobenzene Journal of the Chemical Society-Dalton Transactions. 1805-1809. DOI: 10.1039/Dt9730001805  0.36
1973 Hill HAO, Sadler PJ, Williams RJP. The effect of 1,3,5-trinitrobenzene on 1H nuclear magnetic resonance and electron paramagnetic resonance spectra of some cobalt(II) porphyrins Journal of the Chemical Society-Dalton Transactions. 1663-1667. DOI: 10.1039/Dt9730001663  0.32
1973 HILL HAO, HORSLER ADJ, SADLER PJ. ChemInform Abstract: (1)H NMR INVESTIGATION OF THE FORMATION OF MOLECULAR SALICYLIDENEIMINATO-COBALT(II), -NICKEL(II), -COPPER(II), AND -ZINC(II) COMPLEXES WITH 1,3,5-TRINITROBENZENE Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197346421  0.656
1973 HILL HAO, SADLER PJ, WILLIAMS RJP. ChemInform Abstract: THE EFFECT OF 1,3,5-TRINITROBENZENE ON (1)H NUCLEAR MAGNETIC RESONANCE AND ELECTRON PARAMAGNETIC RESONANCE SPECTRA OF SOME COBALT(II) PORPHYRINS Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197344412  0.63
1973 BARRY CD, HILL HAO, MANN BE, SADLER PJ, WILLIAMS RJP. ChemInform Abstract: MOLECULAR STRUCTURES OF PORPHYRIN COMPLEXES IN SOLUTION, AN (1)H-NMR-SPECTROSKOPIC INVESTIGATION OF THE INTERACTION BETWEEN 2,4,7-TRINITROFLUORENONE AND NICKEL(II) AND COBALT(II) MESOPORPHYRIN IX DIMETHYLESTERS Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197337342  0.36
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