Year |
Citation |
Score |
2023 |
Yang PC, Rose A, DeMarco KR, Dawson JRD, Han Y, Jeng MT, Harvey RD, Santana LF, Ripplinger CM, Vorobyov I, Lewis TJ, Clancy CE. A multiscale predictive digital twin for neurocardiac modulation. The Journal of Physiology. PMID 37528537 DOI: 10.1113/JP284391 |
0.324 |
|
2022 |
Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of the hERG potassium channel and associated drug interactions. Frontiers in Pharmacology. 13: 966463. PMID 36188564 DOI: 10.3389/fphar.2022.966463 |
0.306 |
|
2022 |
Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S. Pore opening, not voltage sensor movement, underpins the voltage-dependence of facilitation by a hERG blocker. Molecular Pharmacology. PMID 36041862 DOI: 10.1124/molpharm.122.000569 |
0.31 |
|
2021 |
Docken SS, Clancy CE, Lewis TJ. Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model. Plos Computational Biology. 17: e1009145. PMID 34185778 DOI: 10.1371/journal.pcbi.1009145 |
0.308 |
|
2021 |
Yang PC, Giles WR, Belardinelli L, Clancy CE. Mechanisms of flecainide induced negative inotropy: An in silico study. Journal of Molecular and Cellular Cardiology. PMID 34004185 DOI: 10.1016/j.yjmcc.2021.05.007 |
0.372 |
|
2018 |
Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy CE, Duff HJ, Noskov SY. Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study. Frontiers in Physiology. 9: 207. PMID 29706893 DOI: 10.3389/Fphys.2018.00207 |
0.365 |
|
2016 |
Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE. Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. The Journal of Physiology. 594: 6433-6435. PMID 27800622 DOI: 10.1113/Jp273143 |
0.433 |
|
2016 |
DeMarco KR, Clancy CE. Cardiac Na Channels: Structure to Function. Current Topics in Membranes. 78: 287-311. PMID 27586288 DOI: 10.1016/bs.ctm.2016.05.001 |
0.305 |
|
2016 |
Yang PC, El-Bizri N, Romero L, Giles WR, Rajamani S, Belardinelli L, Clancy CE. A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current. Journal of Molecular and Cellular Cardiology. PMID 27545042 DOI: 10.1016/J.Yjmcc.2016.08.011 |
0.322 |
|
2016 |
Moreno JD, Lewis TJ, Clancy CE. Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs. Plos One. 11: e0150761. PMID 26963710 DOI: 10.1371/Journal.Pone.0150761 |
0.559 |
|
2016 |
Gray B, Bagnall R, Lam L, Ingles J, Turner C, Haan E, Davis A, Yang P, Clancy C, Sy R, Semsarian C. A Novel Heterozygous Mutation in Cardiac Calsequestrin Causes Catecholaminergic Polymorphic Ventricular Tachycardia Heart, Lung and Circulation. 25: S2-S3. DOI: 10.1016/J.Hlc.2016.06.005 |
0.34 |
|
2016 |
Vincent M, Yang P, Clancy CE. A Computational Modeling Investigation into SCN10A Linked Brugada Syndrome Biophysical Journal. 110: 107a-108a. DOI: 10.1016/J.Bpj.2015.11.637 |
0.36 |
|
2016 |
Yang P, Boras B, Jeng M, Docken S, Lewis T, McCulloch A, Harvey R, Clancy C. A Computational Investigation Predicts Mechanisms of Subcellular cAMP Compartmentation Biophysical Journal. 110: 590a. DOI: 10.1016/J.Bpj.2015.11.3151 |
0.364 |
|
2015 |
Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of Molecular and Cellular Cardiology. 87: 271-82. PMID 26859003 |
0.337 |
|
2015 |
Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov S, Clancy CE. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. The Journal of Physiology. PMID 26515697 DOI: 10.1113/Jp271282 |
0.599 |
|
2015 |
Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY. Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel. Biophysical Journal. 108: 1414-24. PMID 25809254 DOI: 10.1016/J.Bpj.2014.12.056 |
0.328 |
|
2015 |
Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, et al. Deranged sodium to sudden death. The Journal of Physiology. 593: 1331-45. PMID 25772289 DOI: 10.1113/Jphysiol.2014.281204 |
0.318 |
|
2015 |
Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. The Journal of Physiology. 593: 1429-42. PMID 25545172 DOI: 10.1113/jphysiol.2014.279554 |
0.346 |
|
2014 |
Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of Molecular and Cellular Cardiology. 72: 126-37. PMID 24631769 DOI: 10.1016/j.yjmcc.2014.02.018 |
0.339 |
|
2014 |
Agarwal SR, Yang P, Clancy C, Harvey R. Compartmentation of Camp Signaling in Complex and Simple Cells Biophysical Journal. 106: 776a-777a. DOI: 10.1016/J.Bpj.2013.11.4258 |
0.317 |
|
2013 |
Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circulation Research. 113: e50-61. PMID 23897695 DOI: 10.1161/Circresaha.113.301971 |
0.75 |
|
2013 |
Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy CE, Lu JT, Moss AJ, Difrancesco D, Robinson RB. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia. Journal of Cardiovascular Electrophysiology. 24: 1021-7. PMID 23631727 DOI: 10.1111/Jce.12163 |
0.733 |
|
2013 |
Lewin N, Aksay E, Clancy CE. Correction: Computational Modeling Reveals Dendritic Origins of GABAA-Mediated Excitation in CA1 Pyramidal Neurons Plos One. 8. DOI: 10.1371/Annotation/D6Af29Ee-25C0-4F8E-910E-Afe53Ef8F963 |
0.718 |
|
2012 |
Lewin N, Aksay E, Clancy CE. Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. Plos One. 7: e47250. PMID 23071770 DOI: 10.1371/Journal.Pone.0047250 |
0.729 |
|
2012 |
Roberts BN, Yang PC, Behrens SB, Moreno JD, Clancy CE. Computational approaches to understand cardiac electrophysiology and arrhythmias. American Journal of Physiology. Heart and Circulatory Physiology. 303: H766-83. PMID 22886409 DOI: 10.1152/Ajpheart.01081.2011 |
0.577 |
|
2012 |
Moreno JD, Clancy CE. Pathophysiology of the cardiac late Na current and its potential as a drug target. Journal of Molecular and Cellular Cardiology. 52: 608-19. PMID 22198344 DOI: 10.1016/J.Yjmcc.2011.12.003 |
0.622 |
|
2011 |
Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Science Translational Medicine. 3: 98ra83. PMID 21885405 DOI: 10.1126/Scitranslmed.3002588 |
0.754 |
|
2010 |
Oren RV, Clancy CE. Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. Plos Computational Biology. 6: e1001041. PMID 21203483 DOI: 10.1371/Journal.Pcbi.1001041 |
0.729 |
|
2010 |
Yang PC, Kurokawa J, Furukawa T, Clancy CE. Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. Plos Computational Biology. 6: e1000658. PMID 20126530 DOI: 10.1371/Journal.Pcbi.1000658 |
0.309 |
|
2010 |
Protas L, Oren RV, Clancy CE, Robinson RB. Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node. Journal of Molecular and Cellular Cardiology. 48: 172-80. PMID 19665465 DOI: 10.1016/J.Yjmcc.2009.07.028 |
0.728 |
|
2010 |
Moreno JD, Bankston JR, Kass RS, Clancy C. Cardiac Dynamics In-Silico: Pharmacological Targeting of Long QT3 Syndrome Biophysical Journal. 98: 8a. DOI: 10.1016/J.Bpj.2009.12.050 |
0.756 |
|
2009 |
Moreno JD, Clancy CE. Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy. Drug Discovery Today. Disease Models. 6: 71-84. PMID 20652086 DOI: 10.1016/J.Ddmod.2010.03.001 |
0.603 |
|
2009 |
Zhao X, Bucchi A, Oren RV, Kryukova Y, Dun W, Clancy CE, Robinson RB. In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality. The Journal of Physiology. 587: 1513-25. PMID 19171659 DOI: 10.1113/Jphysiol.2008.163444 |
0.737 |
|
2008 |
Furukawa T, Kurokawa J, Clancy CE. A Combined Approach Using Patch-Clamp Study and Computer Simulation Study for Understanding Long QT Syndrome and TdP in Women. Current Cardiology Reviews. 4: 244-50. PMID 20066131 DOI: 10.2174/157340308786349507 |
0.336 |
|
2007 |
Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy CE, Isobe M, Furukawa T. Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation. 116: 2913-22. PMID 18056530 DOI: 10.1161/Circulationaha.107.702407 |
0.722 |
|
2007 |
Zhu ZI, Clancy CE. Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram. Journal of Electrocardiology. 40: S47-50. PMID 17993328 DOI: 10.1016/j.jelectrocard.2007.05.033 |
0.338 |
|
2007 |
Zhu ZI, Clancy CE. L-type Ca2+ channel mutations and T-wave alternans: a model study. American Journal of Physiology. Heart and Circulatory Physiology. 293: H3480-9. PMID 17933974 DOI: 10.1152/ajpheart.00476.2007 |
0.337 |
|
2007 |
Clancy CE, Wehrens XH. Mutation-specific effects of lidocaine in Brugada syndrome. International Journal of Cardiology. 121: 249-52. PMID 17761312 DOI: 10.1016/j.ijcard.2007.05.060 |
0.32 |
|
2007 |
Clancy CE, Zhu ZI, Rudy Y. Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. American Journal of Physiology. Heart and Circulatory Physiology. 292: H66-75. PMID 16997895 DOI: 10.1152/Ajpheart.00312.2006 |
0.316 |
|
2006 |
Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D. C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon. Human Molecular Genetics. 15: 2888-902. PMID 16923798 DOI: 10.1093/Hmg/Ddl230 |
0.305 |
|
2006 |
Glaaser IW, Clancy CE. Cardiac Na+ channels as therapeutic targets for antiarrhythmic agents. Handbook of Experimental Pharmacology. 99-121. PMID 16610342 DOI: 10.1007/3-540-29715-4_4 |
0.314 |
|
2005 |
Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circulation Research. 96: e25-34. PMID 15731462 DOI: 10.1161/01.Res.0000160555.58046.9A |
0.307 |
|
2005 |
Clancy CE, Kass RS. Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels. Physiological Reviews. 85: 33-47. PMID 15618477 DOI: 10.1152/physrev.00005.2004 |
0.316 |
|
2003 |
Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 107: 2233-7. PMID 12695286 DOI: 10.1161/01.CIR.0000069273.51375.BD |
0.338 |
|
2002 |
Clancy CE, Tateyama M, Kass RS. Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. The Journal of Clinical Investigation. 110: 1251-62. PMID 12417563 DOI: 10.1172/JCI15928 |
0.32 |
|
2002 |
Clancy CE, Kass RS. Defective cardiac ion channels: from mutations to clinical syndromes. The Journal of Clinical Investigation. 110: 1075-7. PMID 12393842 DOI: 10.1172/JCI16945 |
0.361 |
|
2002 |
Rivolta I, Clancy CE, Tateyama M, Liu H, Priori SG, Kass RS. A novel SCN5A mutation associated with long QT-3: altered inactivation kinetics and channel dysfunction. Physiological Genomics. 10: 191-7. PMID 12209021 DOI: 10.1152/physiolgenomics.00039.2002 |
0.334 |
|
2001 |
Clancy CE, Rudy Y. Cellular consequences of HERG mutations in the long QT syndrome: Precursors to sudden cardiac death Cardiovascular Research. 50: 301-313. PMID 11334834 DOI: 10.1016/S0008-6363(00)00293-5 |
0.352 |
|
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