Year |
Citation |
Score |
2023 |
Woo JA, Liu T, Fang CC, Cazzaro S, Kee T, LePochat P, Yrigoin K, Penn C, Zhao X, Wang X, Liggett SB, Kang DE. Author Correction: Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics. Communications Biology. 6: 1283. PMID 38114710 DOI: 10.1038/s42003-023-05644-x |
0.766 |
|
2023 |
Lefkowitz RJ, Rockman HA, Shim PJ, Liu S, Ahn S, Pani B, Rajagopal S, Shenoy SK, Bouvier M, Benovic JL, Liggett SB, Ruffolo RR, Bristow MR, Packer M. How carvedilol does not activate β-adrenoceptors. Nature Communications. 14: 7866. PMID 38036531 DOI: 10.1038/s41467-023-42848-5 |
0.752 |
|
2023 |
Woo JA, Castaño M, Kee TR, Lee J, Koziol-White CJ, An SS, Kim D, Kang DE, Liggett SB. A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14. American Journal of Respiratory Cell and Molecular Biology. PMID 36662576 DOI: 10.1165/rcmb.2022-0303OC |
0.805 |
|
2022 |
Kim D, Tokmakova A, Woo JA, An SS, Goddard WA, Liggett SB. Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development. Molecular Diagnosis & Therapy. PMID 35595932 DOI: 10.1007/s40291-022-00592-4 |
0.324 |
|
2022 |
Tokmakova A, Kim D, Goddard WA, Liggett SB. Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease. Journal of Personalized Medicine. 12. PMID 35330331 DOI: 10.3390/jpm12030331 |
0.334 |
|
2022 |
Woo JA, Yan Y, Kee TR, Cazzaro S, McGill Percy KC, Wang X, Liu T, Liggett SB, Kang DE. β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy. Life Science Alliance. 5. PMID 34862271 DOI: 10.26508/lsa.202101183 |
0.802 |
|
2021 |
Kim D, Tokmakova A, Lujan LK, Strzelinski HR, Kim N, Najari Beidokhti M, Giulianotti MA, Mafi A, Woo JA, An SS, Goddard WA, Liggett SB. Identification and characterization of an atypical Gαs-biased βAR agonist that fails to evoke airway smooth muscle cell tachyphylaxis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34857633 DOI: 10.1073/pnas.2026668118 |
0.735 |
|
2021 |
Kim D, Castaño M, Lujan LK, Woo JA, Liggett SB. The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14. The Journal of Biological Chemistry. 100216. PMID 33465377 DOI: 10.1074/jbc.RA120.016056 |
0.701 |
|
2020 |
Woo JA, Liu T, Fang CC, Castaño MA, Kee T, Yrigoin K, Yan Y, Cazzaro S, Matlack J, Wang X, Zhao X, Kang DE, Liggett SB. β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates. Proceedings of the National Academy of Sciences of the United States of America. PMID 32071246 DOI: 10.1073/Pnas.1917194117 |
0.776 |
|
2019 |
Woo JA, Liu T, Fang CC, Cazzaro S, Kee T, LePochat P, Yrigoin K, Penn C, Zhao X, Wang X, Liggett SB, Kang DE. Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics. Communications Biology. 2: 112. PMID 31924969 DOI: 10.1038/s42003-019-0359-9 |
0.768 |
|
2019 |
Woo JA, Castaño M, Goss A, Kim D, Lewandowski EM, Chen Y, Liggett SB. Differential long-term regulation of TAS2R14 by structurally distinct agonists. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802627RR. PMID 31430434 DOI: 10.1096/Fj.201802627Rr |
0.754 |
|
2019 |
Woo JA, Liu T, Fang CC, Cazzaro S, Kee T, LePochat P, Yrigoin K, Penn C, Zhao X, Wang X, Liggett SB, Kang DE. Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics. Communications Biology. 2: 112. PMID 30911686 DOI: 10.1038/s42003-019-0359-9 |
0.762 |
|
2019 |
Woo JA, Liu T, Fang C, Cazzaro S, Kee T, Lepochat P, Yrigoin K, Zhao X, Wang X, Liggett S, Kang D. Role of cofilin in tau/microtubule dynamics and tauopathy Ibro Reports. 6: S366. DOI: 10.1016/J.Ibror.2019.07.1163 |
0.753 |
|
2018 |
Rajan S, Jagatheesan G, Petrashevskaya N, Biesiadecki BJ, Warren CM, Riddle T, Liggett SB, Wolska BM, Solaro RJ, Wieczorek DF. Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy. The Journal of Biological Chemistry. PMID 30567734 DOI: 10.1074/Jbc.Ra118.004879 |
0.351 |
|
2018 |
Kim D, Cho S, Castaño MA, Panettieri RA, Woo JA, Liggett SB. Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating pERK1/2. American Journal of Respiratory Cell and Molecular Biology. PMID 30365340 DOI: 10.1165/Rcmb.2018-0189Oc |
0.741 |
|
2018 |
Panettieri RA, Pera T, Liggett SB, Benovic JL, Penn RB. Pepducins as a potential treatment strategy for asthma and COPD. Current Opinion in Pharmacology. 40: 120-125. PMID 29729548 DOI: 10.1016/J.Coph.2018.04.008 |
0.493 |
|
2018 |
Liggett SB. Genetic Vulnerability of GPCRs: A Call to Action. Trends in Biochemical Sciences. 43: 227-229. PMID 29605062 DOI: 10.1016/J.Tibs.2018.02.006 |
0.321 |
|
2018 |
Kim D, Cho S, Woo JA, Liggett SB. A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β-adrenergic receptor down-regulation in airway smooth muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701278R. PMID 29455573 DOI: 10.1096/Fj.201701278R |
0.749 |
|
2017 |
An SS, Liggett SB. Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system. Cellular Signalling. PMID 28167233 DOI: 10.1016/J.Cellsig.2017.02.002 |
0.422 |
|
2017 |
Kim D, Woo JA, Geffken E, An SS, Liggett SB. Coupling of Airway Smooth Muscle TAS2Rs to Intracellular Signaling and Relaxation is via Gαi1,2,3. American Journal of Respiratory Cell and Molecular Biology. PMID 28145731 DOI: 10.1165/Rcmb.2016-0373Oc |
0.735 |
|
2016 |
Aisenberg WH, Huang J, Zhu W, Rajkumar P, Cruz R, Santhanam L, Natarajan N, Yong HM, De Santiago B, Oh JJ, Yoon AR, Panettieri RA, Homann O, Sullivan JK, Liggett SB, et al. Defining an olfactory receptor function in airway smooth muscle cells. Scientific Reports. 6: 38231. PMID 27905542 DOI: 10.1038/Srep38231 |
0.381 |
|
2016 |
Koziol-White CJ, Yoo EJ, Cao G, Zhang J, Papanikolaou E, Pushkarsky I, Andrews A, Himes BE, Damoiseaux RD, Liggett SB, Di Carlo D, Kurten RC, Panettieri RA. Inhibition of Phosphoinositide 3-Kinase (PI3K) promotes dilation of human small airways in a Rho kinase-dependent manner. British Journal of Pharmacology. PMID 27352269 DOI: 10.1111/Bph.13542 |
0.305 |
|
2016 |
Kim D, Pauer SH, Yong HM, An SS, Liggett SB. β2-adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function. The Journal of Biological Chemistry. PMID 27342779 DOI: 10.1074/Jbc.M116.722736 |
0.466 |
|
2015 |
Camoretti-Mercado B, Pauer SH, Yong HM, Smith DC, Deshpande DA, An SS, Liggett SB. Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells. Plos One. 10: e0131582. PMID 26121686 DOI: 10.1371/Journal.Pone.0131582 |
0.311 |
|
2014 |
Wang WC, Pauer SH, Smith DC, Dixon MA, Disimile DJ, Panebra A, An SS, Camoretti-Mercado B, Liggett SB. Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle. American Journal of Physiology. Lung Cellular and Molecular Physiology. 307: L775-80. PMID 25260754 DOI: 10.1152/Ajplung.00209.2014 |
0.473 |
|
2014 |
Robinett KS, Koziol-White CJ, Akoluk A, An SS, Panettieri RA, Liggett SB. Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology. 50: 678-83. PMID 24219573 DOI: 10.1165/Rcmb.2013-0439Rc |
0.377 |
|
2013 |
Aleong RG, Sauer WH, Sauer WH, Murphy GA, Port JD, Anand IS, Fiuzat M, O'Connor CM, Abraham WT, Liggett SB, Bristow MR. Prevention of atrial fibrillation by bucindolol is dependent on the betaâ‚389 Arg/Gly adrenergic receptor polymorphism. Jacc. Heart Failure. 1: 338-44. PMID 24159564 DOI: 10.1016/J.Jchf.2013.04.002 |
0.377 |
|
2013 |
Liggett SB. Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators. Expert Opinion On Therapeutic Targets. 17: 721-31. PMID 23577615 DOI: 10.1517/14728222.2013.782395 |
0.376 |
|
2013 |
Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR. Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure Circulation: Arrhythmia and Electrophysiology. 6: 137-143. PMID 23275278 DOI: 10.1161/Circep.111.969618 |
0.422 |
|
2013 |
Duan QL, Du R, Lasky-Su J, Klanderman BJ, Partch AB, Peters SP, Irvin CG, Hanrahan JP, Lima JJ, Blake KV, Liggett SB, Litonjua AA, Tantisira KG. A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics. The Pharmacogenomics Journal. 13: 130-6. PMID 22212731 DOI: 10.1038/Tpj.2011.56 |
0.342 |
|
2012 |
O'Connor CM, Fiuzat M, Carson PE, Anand IS, Plehn JF, Gottlieb SS, Silver MA, Lindenfeld J, Miller AB, White M, Walsh R, Nelson P, Medway A, Davis G, Robertson AD, ... ... Liggett SB, et al. Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms. Plos One. 7: e44324. PMID 23071495 DOI: 10.1371/Journal.Pone.0044324 |
0.385 |
|
2012 |
Clark AA, Liggett SB, Munger SD. Extraoral bitter taste receptors as mediators of off-target drug effects. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4827-31. PMID 22964302 DOI: 10.1096/Fj.12-215087 |
0.336 |
|
2012 |
Vandell AG, Lobmeyer MT, Gawronski BE, Langaee TY, Gong Y, Gums JG, Beitelshees AL, Turner ST, Chapman AB, Cooper-DeHoff RM, Bailey KR, Boerwinkle E, Pepine CJ, Liggett SB, Johnson JA. G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension. Hypertension. 60: 957-64. PMID 22949529 DOI: 10.1161/Hypertensionaha.112.198721 |
0.328 |
|
2012 |
An SS, Wang WC, Koziol-White CJ, Ahn K, Lee DY, Kurten RC, Panettieri RA, Liggett SB. TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L304-11. PMID 22683571 DOI: 10.1152/Ajplung.00126.2012 |
0.438 |
|
2012 |
Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, et al. Erratum: The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma (International Archives of Allergy and Immunology (2000) 162 (75-80)) International Archives of Allergy and Immunology. 157. DOI: 10.1159/000335957 |
0.414 |
|
2012 |
Liggett SB. Chapter 45 – Adrenergic Receptor Polymorphisms in Heart Failure Musclefundamental Biology and Mechanisms of Disease. 661-672. DOI: 10.1016/B978-0-12-381510-1.00045-4 |
0.414 |
|
2011 |
Dockstader K, Nunley K, Karimpour-Fard A, Medway A, Nelson P, Port JD, Liggett SB, Bristow MR, Sucharov CC. Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the β1-adrenergic receptor. Physiological Genomics. 43: 1294-306. PMID 21954455 DOI: 10.1152/Physiolgenomics.00067.2011 |
0.324 |
|
2011 |
Nagele P, Liggett SB. Genetic variation, β-blockers, and perioperative myocardial infarction. Anesthesiology. 115: 1316-27. PMID 21918425 DOI: 10.1097/Aln.0B013E3182315Eb2 |
0.343 |
|
2011 |
Liggett SB. Phosphorylation barcoding as a mechanism of directing GPCR signaling. Science Signaling. 4: pe36. PMID 21868354 DOI: 10.1126/Scisignal.2002331 |
0.462 |
|
2011 |
Deshpande DA, Robinett KS, Wang WC, Sham JS, An SS, Liggett SB. Bronchodilator activity of bitter tastants in human tissue. Nature Medicine. 17: 776-8. PMID 21738150 DOI: 10.1038/Nm0711-776B |
0.365 |
|
2011 |
Robinett KS, Deshpande DA, Malone MM, Liggett SB. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. American Journal of Respiratory Cell and Molecular Biology. 45: 1069-74. PMID 21642585 DOI: 10.1165/Rcmb.2011-0061Oc |
0.456 |
|
2011 |
Trian T, Burgess JK, Niimi K, Moir LM, Ge Q, Berger P, Liggett SB, Black JL, Oliver BG. β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D. Plos One. 6: e20000. PMID 21611147 DOI: 10.1371/Journal.Pone.0020000 |
0.395 |
|
2011 |
Wang WC, Juan AH, Panebra A, Liggett SB. MicroRNA let-7 establishes expression of beta2-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation. Proceedings of the National Academy of Sciences of the United States of America. 108: 6246-51. PMID 21447718 DOI: 10.1073/Pnas.1101439108 |
0.321 |
|
2011 |
Johnson JA, Liggett SB. Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions. Clinical Pharmacology and Therapeutics. 89: 366-78. PMID 21289619 DOI: 10.1038/Clpt.2010.315 |
0.458 |
|
2011 |
Wang WC, Schillinger RM, Malone MM, Liggett SB. Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase. American Journal of Physiology. Lung Cellular and Molecular Physiology. 300: L472-8. PMID 21131397 DOI: 10.1152/Ajplung.00273.2010 |
0.426 |
|
2011 |
Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, Irvin CG, Peters SP, Meyers DA, Hanrahan JP, Lima JJ, Litonjua AA, Tantisira KG, Liggett SB. Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. American Journal of Respiratory and Critical Care Medicine. 183: 449-54. PMID 20851928 DOI: 10.1164/Rccm.201005-0758Oc |
0.306 |
|
2010 |
Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nature Medicine. 16: 1299-304. PMID 20972434 DOI: 10.1038/Nm.2237 |
0.417 |
|
2010 |
Jagatheesan G, Rajan S, Ahmed RP, Petrashevskaya N, Boivin G, Arteaga GM, Tae HJ, Liggett SB, Solaro RJ, Wieczorek DF. Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity. Journal of Muscle Research and Cell Motility. 31: 227-39. PMID 20803058 DOI: 10.1007/S10974-010-9228-3 |
0.329 |
|
2010 |
Panebra A, Wang WC, Malone MM, Pitter DR, Weiss ST, Hawkins GA, Liggett SB. Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes. Plos One. 5: e11819. PMID 20686604 DOI: 10.1371/Journal.Pone.0011819 |
0.458 |
|
2010 |
Rajan S, Jagatheesan G, Karam CN, Alves ML, Bodi I, Schwartz A, Bulcao CF, D'Souza KM, Akhter SA, Boivin GP, Dube DK, Petrashevskaya N, Herr AB, Hullin R, Liggett SB, et al. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation. 121: 410-8. PMID 20065163 DOI: 10.1161/Circulationaha.109.889725 |
0.622 |
|
2010 |
Liggett SB. Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure. Heart Failure Clinics. 6: 27-33. PMID 19945058 DOI: 10.1016/J.Hfc.2009.08.011 |
0.415 |
|
2010 |
Bristow MR, Murphy GA, Krause-Steinrauf H, Anderson JL, Carlquist JF, Thaneemit-Chen S, Krishnan V, Abraham WT, Lowes BD, Port JD, Davis GW, Lazzeroni LC, Robertson AD, Lavori PW, Liggett SB. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Circulation. Heart Failure. 3: 21-8. PMID 19880803 DOI: 10.1161/Circheartfailure.109.885962 |
0.426 |
|
2009 |
Liggett SB. alpha2A-adrenergic receptors in the genetics, pathogenesis, and treatment of type 2 diabetes. Science Translational Medicine. 1: 12ps15. PMID 20371458 DOI: 10.1126/Scitranslmed.3000606 |
0.315 |
|
2009 |
Wang WC, Mihlbachler KA, Brunnett AC, Liggett SB. Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 15007-12. PMID 19706446 DOI: 10.1073/Pnas.0906034106 |
0.499 |
|
2009 |
Dorn GW, Liggett SB. Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure. Molecular Pharmacology. 76: 466-80. PMID 19491328 DOI: 10.1124/Mol.109.056572 |
0.397 |
|
2009 |
Jagatheesan G, Rajan S, Schulz EM, Ahmed RP, Petrashevskaya N, Schwartz A, Boivin GP, Arteaga GM, Wang T, Wang YG, Ashraf M, Liggett SB, Lorenz J, Solaro RJ, Wieczorek DF. An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity. American Journal of Physiology. Heart and Circulatory Physiology. 297: H181-90. PMID 19429821 DOI: 10.1152/Ajpheart.00329.2008 |
0.344 |
|
2009 |
Jagatheesan G, Schulz EM, Ahmed RP, Petrashevskaya N, Schwartz A, Boivin GP, Arteaga GM, Liggett SB, Solaro RJ, Wieczorek DF. An Internal Domain of Beta Tropomyosin Increases Myofilament Calcium Sensitivity Biophysical Journal. 96: 504a. DOI: 10.1016/J.Bpj.2008.12.2597 |
0.338 |
|
2008 |
Dorn GW, Liggett SB. Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure. Clinical and Translational Science. 1: 255-62. PMID 20443857 DOI: 10.1111/j.1752-8062.2008.00059.x |
0.33 |
|
2008 |
Kardia SL, Kelly RJ, Keddache MA, Aronow BJ, Grabowski GA, Hahn HS, Case KL, Wagoner LE, Dorn GW, Liggett SB. Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival. Bmc Medical Genetics. 9: 93. PMID 18947427 DOI: 10.1186/1471-2350-9-93 |
0.36 |
|
2008 |
Sehnert AJ, Daniels SE, Elashoff M, Wingrove JA, Burrow CR, Horne B, Muhlestein JB, Donahue M, Liggett SB, Anderson JL, Kraus WE. Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. Journal of the American College of Cardiology. 52: 644-51. PMID 18702968 DOI: 10.1016/J.Jacc.2008.05.022 |
0.368 |
|
2008 |
Swift SM, Gaume BR, Small KM, Aronow BJ, Liggett SB. Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs. Physiological Genomics. 35: 123-31. PMID 18664629 DOI: 10.1152/Physiolgenomics.90225.2008 |
0.446 |
|
2008 |
Wang WC, Mihlbachler KA, Bleecker ER, Weiss ST, Liggett SB. A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. Pharmacogenetics and Genomics. 18: 729-32. PMID 18622265 DOI: 10.1097/Fpc.0B013E32830967E9 |
0.446 |
|
2008 |
Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SL, Dorn GW. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nature Medicine. 14: 510-7. PMID 18425130 DOI: 10.1038/Nm1750 |
0.571 |
|
2008 |
Einstein R, Jordan H, Zhou W, Brenner M, Moses EG, Liggett SB. Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 5230-5. PMID 18362331 DOI: 10.1073/Pnas.0801319105 |
0.432 |
|
2008 |
Small KM, Mialet-Perez J, Liggett SB. Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes. Journal of Cardiovascular Pharmacology. 51: 106-10. PMID 18209576 DOI: 10.1097/Fjc.0B013E31815A958F |
0.361 |
|
2008 |
Panebra A, Schwarb MR, Swift SM, Weiss ST, Bleecker ER, Hawkins GA, Liggett SB. Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L190-5. PMID 18024720 DOI: 10.1152/Ajplung.00277.2007 |
0.417 |
|
2007 |
Liggett SB, Kelly RJ, Parekh RR, Matkovich SJ, Benner BJ, Hahn HS, Syed FM, Galvez AS, Case KL, McGuire N, Odley AM, Sparks L, Kardia SL, Dorn GW. A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. Human Molecular Genetics. 16: 2740-50. PMID 17720980 DOI: 10.1093/Hmg/Ddm229 |
0.343 |
|
2007 |
Petrashevskaya N, Liggett SB. Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure. Cardiovascular Research. 75: 631-3. PMID 17643402 DOI: 10.1016/J.Cardiores.2007.07.005 |
0.346 |
|
2007 |
Panebra A, Schwarb MR, Glinka CB, Liggett SB. Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 293: L453-62. PMID 17557803 DOI: 10.1152/Ajplung.00084.2007 |
0.345 |
|
2007 |
Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF. Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circulation Research. 101: 205-14. PMID 17556658 DOI: 10.1161/Circresaha.107.148379 |
0.349 |
|
2007 |
McGraw DW, Elwing JM, Fogel KM, Wang WC, Glinka CB, Mihlbachler KA, Rothenberg ME, Liggett SB. Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. The Journal of Clinical Investigation. 117: 1391-8. PMID 17415415 DOI: 10.1172/Jci30489 |
0.361 |
|
2007 |
Liggett SB. Long-distance affair with adrenal GRK2 hangs up heart failure. Nature Medicine. 13: 246-8. PMID 17342115 DOI: 10.1038/Nm0307-246 |
0.335 |
|
2007 |
Panebra A, Schwarb MR, Glinka CB, Liggett SB. Allele-specific binding of airway nuclear extracts to polymorphic beta2-adrenergic receptor 5' sequence. American Journal of Respiratory Cell and Molecular Biology. 36: 654-60. PMID 17255556 DOI: 10.1165/Rcmb.2006-0394Oc |
0.394 |
|
2007 |
Swift SM, Schwarb MR, Mihlbachler KA, Liggett SB. Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity. American Journal of Respiratory Cell and Molecular Biology. 36: 236-43. PMID 16980553 DOI: 10.1165/Rcmb.2006-0257Oc |
0.482 |
|
2007 |
Bodi I, D'Souza K, Liggett SB, Schwartz A. WITHDRAWN: Enhanced Ca2+ transient & cell contractility is associated with decreased Cx43 in β1-ARG389 mice Journal of Molecular and Cellular Cardiology. DOI: 10.1016/J.Yjmcc.2007.03.853 |
0.302 |
|
2007 |
Bodi I, D'Souza K, Liggett S, Schwartz A. Enhanced Ca2+ transient and cell contractility is associated with decreased Cx43 in β1-ARG389 mice Journal of Molecular and Cellular Cardiology. 42: S110. DOI: 10.1016/J.Yjmcc.2007.03.249 |
0.302 |
|
2006 |
Liggett SB. Genetic variability of the beta2 adrenergic receptor and asthma exacerbations. Thorax. 61: 925-7. PMID 17071831 DOI: 10.1136/Thx.2006.064006 |
0.408 |
|
2006 |
Hawkins GA, Tantisira K, Meyers DA, Ampleford EJ, Moore WC, Klanderman B, Liggett SB, Peters SP, Weiss ST, Bleecker ER. Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. American Journal of Respiratory and Critical Care Medicine. 174: 1101-9. PMID 16931635 DOI: 10.1164/Rccm.200509-1405Oc |
0.36 |
|
2006 |
McGraw DW, Fogel KM, Kong S, Litonjua AA, Kranias EG, Aronow BJ, Liggett SB. Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. Physiological Genomics. 27: 171-7. PMID 16849635 DOI: 10.1152/Physiolgenomics.00044.2006 |
0.429 |
|
2006 |
Liggett SB, Mialet-Perez J, Thaneemit-Chen S, Weber SA, Greene SM, Hodne D, Nelson B, Morrison J, Domanski MJ, Wagoner LE, Abraham WT, Anderson JL, Carlquist JF, Krause-Steinrauf HJ, Lazzeroni LC, et al. A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Proceedings of the National Academy of Sciences of the United States of America. 103: 11288-93. PMID 16844790 DOI: 10.1073/Pnas.0509937103 |
0.444 |
|
2006 |
McGraw DW, Mihlbachler KA, Schwarb MR, Rahman FF, Small KM, Almoosa KF, Liggett SB. Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. The Journal of Clinical Investigation. 116: 1400-9. PMID 16670773 DOI: 10.1172/Jci25840 |
0.47 |
|
2006 |
Liggett SB. Beta2-adrenergic receptor polymorphisms and sudden cardiac death: a signal to follow. Circulation. 113: 1818-20. PMID 16618829 DOI: 10.1161/Circulationaha.105.618967 |
0.374 |
|
2006 |
Small KM, Schwarb MR, Glinka C, Theiss CT, Brown KM, Seman CA, Liggett SB. Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment. Biochemistry. 45: 4760-7. PMID 16605244 DOI: 10.1021/Bi052074Z |
0.345 |
|
2006 |
Liggett SB. Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify. The Journal of Clinical Investigation. 116: 875-7. PMID 16585959 DOI: 10.1172/Jci28234 |
0.392 |
|
2006 |
Small KM, Brown KM, Seman CA, Theiss CT, Liggett SB. Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 103: 5472-7. PMID 16567612 DOI: 10.1073/Pnas.0601345103 |
0.336 |
|
2006 |
Akhter SA, D'Souza KM, Petrashevskaya NN, Mialet-Perez J, Liggett SB. Myocardial β1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury American Journal of Physiology - Heart and Circulatory Physiology. 290. PMID 16537791 DOI: 10.1152/Ajpheart.00908.2005 |
0.666 |
|
2006 |
Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, ... ... Liggett SB, et al. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation. 113: 995-1004. PMID 16476846 DOI: 10.1161/Circulationaha.105.583351 |
0.302 |
|
2006 |
Liggett SB, Kelly R, Matkovich SJ, Hahn HS, Syed FM, Marreez Y, Case KL, McGuire N, Brunskill EW, Odley AM, Parekh R, Sparks L, Koch WJ, Freeman GL, Kardia SL, et al. G-Protein Receptor Kinase-5 Polymorphism Influences Therapeutic Efficacy of β-Blockers in Heart Failure Journal of Cardiac Failure. 12: S39. DOI: 10.1016/J.Cardfail.2006.06.138 |
0.559 |
|
2005 |
McGraw DW, Liggett SB. Molecular mechanisms of beta2-adrenergic receptor function and regulation. Proceedings of the American Thoracic Society. 2: 292-6; discussion 31. PMID 16267351 DOI: 10.1513/pats.200504-027SR |
0.381 |
|
2005 |
Liggett SB. Lymphocyte GRK levels as biomarkers in heart failure. European Heart Journal. 26: 1695-6. PMID 16055498 DOI: 10.1093/Eurheartj/Ehi355 |
0.437 |
|
2005 |
Tantisira KG, Small KM, Litonjua AA, Weiss ST, Liggett SB. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. Human Molecular Genetics. 14: 1671-7. PMID 15879435 DOI: 10.1093/Hmg/Ddi175 |
0.405 |
|
2005 |
Meyers D, Hawkins G, Tantisira K, Ampleford E, Hernandez M, Richter B, Peters S, Liggett S, Weiss S, Bleecker E. Detailed sequence and haplotype analysis of the beta-2 adrenergic receptor gene in Caucasians and African Americans Journal of Allergy and Clinical Immunology. 115: S148-S149. DOI: 10.1016/J.Jaci.2004.12.605 |
0.395 |
|
2004 |
Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Liggett SB, et al. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (London, England). 364: 1505-12. PMID 15500895 DOI: 10.1016/S0140-6736(04)17273-5 |
0.37 |
|
2004 |
Liggett SB. Polymorphisms of beta-adrenergic receptors in heart failure. The American Journal of Medicine. 117: 525-7. PMID 15464712 DOI: 10.1016/J.Amjmed.2004.07.039 |
0.429 |
|
2004 |
Small KM, Mialet-Perez J, Seman CA, Theiss CT, Brown KM, Liggett SB. Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. Proceedings of the National Academy of Sciences of the United States of America. 101: 13020-5. PMID 15319474 DOI: 10.1073/Pnas.0405074101 |
0.366 |
|
2004 |
Mialet-Perez J, Green SA, Miller WE, Liggett SB. A primate-dominant third glycosylation site of the beta2-adrenergic receptor routes receptors to degradation during agonist regulation. The Journal of Biological Chemistry. 279: 38603-7. PMID 15247302 DOI: 10.1074/Jbc.M403708200 |
0.671 |
|
2004 |
Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, et al. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Human Molecular Genetics. 13: 1353-9. PMID 15128701 DOI: 10.1093/Hmg/Ddh149 |
0.31 |
|
2004 |
Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, et al. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature Medicine. 10: 248-54. PMID 14966518 DOI: 10.1038/Nm1000 |
0.331 |
|
2003 |
Liggett SB. Polymorphisms of adrenergic receptors: variations on a theme. Assay and Drug Development Technologies. 1: 317-26. PMID 15090197 DOI: 10.1089/15406580360545134 |
0.43 |
|
2003 |
Gerson MC, Wagoner LE, McGuire N, Liggett SB. Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic alpha2C-adrenergic receptor. Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology. 10: 583-9. PMID 14668769 DOI: 10.1016/J.Nuclcard.2003.07.001 |
0.343 |
|
2003 |
Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF, Vatner DE. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 108: 2926-33. PMID 14623810 DOI: 10.1161/01.Cir.0000101922.18151.7B |
0.4 |
|
2003 |
Hahn HS, Marreez Y, Odley A, Sterbling A, Yussman MG, Hilty KC, Bodi I, Liggett SB, Schwartz A, Dorn GW. Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. Circulation Research. 93: 1111-9. PMID 14605019 DOI: 10.1161/01.Res.0000105087.79373.17 |
0.386 |
|
2003 |
Mialet Perez J, Rathz DA, Petrashevskaya NN, Hahn HS, Wagoner LE, Schwartz A, Dorn GW, Liggett SB. Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nature Medicine. 9: 1300-5. PMID 14502278 DOI: 10.1038/Nm930 |
0.803 |
|
2003 |
Small KM, Brown KM, Theiss CT, Seman CA, Weiss ST, Liggett SB. An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. Pharmacogenetics. 13: 535-41. PMID 12972952 DOI: 10.1097/00008571-200309000-00002 |
0.448 |
|
2003 |
McGraw DW, Almoosa KF, Paul RJ, Kobilka BK, Liggett SB. Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. The Journal of Clinical Investigation. 112: 619-26. PMID 12925702 DOI: 10.1172/Jci18193 |
0.613 |
|
2003 |
Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, Fan GC, Tsiapras D, Hahn HS, Adamopoulos S, Liggett SB, Dorn GW, MacLennan DH, Kremastinos DT, Kranias EG. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. The Journal of Clinical Investigation. 111: 869-76. PMID 12639993 DOI: 10.1172/Jci17892 |
0.302 |
|
2003 |
Small KM, Tanguay DA, Nandabalan K, Zhan P, Stephens JC, Liggett SB. Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 3: 65-71. PMID 12562217 DOI: 10.2165/00129785-200303010-00008 |
0.383 |
|
2003 |
Meisel C, Köpke K, Roots I, Maitland ML, Gomberg-Maitland M, Little J, Gwinn M, Khoury M, Kardia SLR, Levin AM, Liggett SB. Polymorphisms of adrenergic receptors and the risk of heart failure [2] (multiple letters) New England Journal of Medicine. 348: 468-470. PMID 12556550 DOI: 10.1056/Nejm200301303480518 |
0.367 |
|
2003 |
Small KM, McGraw DW, Liggett SB. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annual Review of Pharmacology and Toxicology. 43: 381-411. PMID 12540746 DOI: 10.1146/Annurev.Pharmtox.43.100901.135823 |
0.441 |
|
2003 |
Rathz DA, Gregory KN, Fang Y, Brown KM, Liggett SB. Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling. The Journal of Biological Chemistry. 278: 10784-9. PMID 12525504 DOI: 10.1074/Jbc.M206054200 |
0.816 |
|
2002 |
Liggett SB. Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling. The Journal of Allergy and Clinical Immunology. 110: S223-7. PMID 12464928 DOI: 10.1067/Mai.2002.129945 |
0.447 |
|
2002 |
Lalchandani SG, Lei L, Zheng W, Suni MM, Moore BM, Liggett SB, Miller DD, Feller DR. Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype. The Journal of Pharmacology and Experimental Therapeutics. 303: 979-84. PMID 12438517 DOI: 10.1124/Jpet.102.039057 |
0.304 |
|
2002 |
Wagoner LE, Craft LL, Zengel P, McGuire N, Rathz DA, Dorn GW, Liggett SB. Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure. American Heart Journal. 144: 840-6. PMID 12422153 DOI: 10.1067/Mhj.2002.125325 |
0.795 |
|
2002 |
Small KM, Wagoner LE, Levin AM, Kardia SL, Liggett SB. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. The New England Journal of Medicine. 347: 1135-42. PMID 12374873 DOI: 10.1056/Nejmoa020803 |
0.47 |
|
2002 |
Small KM, Seman CA, Castator A, Brown KM, Liggett SB. False positive non-synonymous polymorphisms of G-protein coupled receptor genes. Febs Letters. 516: 253-6. PMID 11959142 DOI: 10.1016/S0014-5793(02)02564-4 |
0.385 |
|
2002 |
Liang M, Eason MG, Theiss CT, Liggett SB. Phosphorylation of Ser360 in the third intracellular loop of the alpha2A-adrenoceptor during protein kinase C-mediated desensitization. European Journal of Pharmacology. 437: 41-6. PMID 11864637 DOI: 10.1016/S0014-2999(02)01280-3 |
0.683 |
|
2002 |
Liggett SB. Polymorphisms of the beta2-adrenergic receptor. The New England Journal of Medicine. 346: 536-8. PMID 11844862 DOI: 10.1056/Nejm200202143460718 |
0.444 |
|
2002 |
Rathz DA, Brown KM, Kramer LA, Liggett SB. Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking. Journal of Cardiovascular Pharmacology. 39: 155-60. PMID 11791000 DOI: 10.1097/00005344-200202000-00001 |
0.821 |
|
2002 |
Small KM, Rathz DA, Liggett SB. Identification of adrenergic receptor polymorphisms. Methods in Enzymology. 343: 459-75. PMID 11665585 DOI: 10.1016/S0076-6879(02)43152-7 |
0.808 |
|
2001 |
Liang M, Freedman NJ, Theiss CT, Liggett SB. Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. Biochemistry. 40: 15031-7. PMID 11732925 DOI: 10.1021/Bi011453Z |
0.78 |
|
2001 |
Small KM, Liggett SB. Identification and functional characterization of α2-adrenoceptor polymorphisms Trends in Pharmacological Sciences. 22: 471-477. PMID 11543875 DOI: 10.1016/S0165-6147(00)01758-2 |
0.418 |
|
2001 |
Green SA, Rathz DA, Schuster AJ, Liggett SB. The Ile164 β2-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to Gs European Journal of Pharmacology. 421: 141-147. PMID 11516429 DOI: 10.1016/S0014-2999(01)01049-4 |
0.796 |
|
2001 |
Small KM, Brown KM, Forbes SL, Liggett SB. Modification of the beta 2-adrenergic receptor to engineer a receptor-effector complex for gene therapy. The Journal of Biological Chemistry. 276: 31596-601. PMID 11402033 DOI: 10.1074/Jbc.M102734200 |
0.504 |
|
2001 |
Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, et al. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. International Archives of Allergy and Immunology. 124: 183-6. PMID 11306963 DOI: 10.1159/000053705 |
0.423 |
|
2001 |
Liggett SB. Beta-adrenergic receptors in the failing heart: the good, the bad, and the unknown. The Journal of Clinical Investigation. 107: 947-8. PMID 11306597 DOI: 10.1172/Jci12774 |
0.422 |
|
2001 |
Dash R, Kadambi V, Schmidt AG, Tepe NM, Biniakiewicz D, Gerst MJ, Canning AM, Abraham WT, Hoit BD, Liggett SB, Lorenz JN, Dorn GW, Kranias EG. Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality. Circulation. 103: 889-96. PMID 11171800 DOI: 10.1161/01.Cir.103.6.889 |
0.344 |
|
2001 |
Small KM, Forbes SL, Brown KM, Liggett SB. An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling. The Journal of Biological Chemistry. 275: 38518-23. PMID 10948191 DOI: 10.1074/Jbc.M004550200 |
0.454 |
|
2000 |
Small KM, Brown KM, Forbes SL, Liggett SB. Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. The Journal of Biological Chemistry. 276: 4917-22. PMID 11056163 DOI: 10.1074/Jbc.M008118200 |
0.458 |
|
2000 |
Drysdale CM, McGraw DW, Stack CB, Stephens JC, Judson RS, Nandabalan K, Arnold K, Ruano G, Liggett SB. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proceedings of the National Academy of Sciences of the United States of America. 97: 10483-8. PMID 10984540 DOI: 10.1073/Pnas.97.19.10483 |
0.422 |
|
2000 |
Liggett SB. Pharmacogenetics of beta-1- and beta-2-adrenergic receptors. Pharmacology. 61: 167-73. PMID 10971202 DOI: 10.1159/000028397 |
0.498 |
|
2000 |
McGraw DW, Forbes SL, Mak JC, Witte DP, Carrigan PE, Leikauf GD, Liggett SB. Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L379-89. PMID 10926562 DOI: 10.1152/Ajplung.2000.279.2.L379 |
0.415 |
|
2000 |
Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, et al. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. American Journal of Respiratory and Critical Care Medicine. 162: 75-80. PMID 10903223 DOI: 10.1164/Ajrccm.162.1.9907092 |
0.398 |
|
2000 |
Jewell-Motz EA, Small KM, Theiss CT, Liggett SB. alpha 2A/alpha 2C-adrenergic receptor third loop chimera show that agonist interaction with receptor subtype backbone establishes G protein-coupled receptor kinase phosphorylation. The Journal of Biological Chemistry. 275: 28989-93. PMID 10893245 DOI: 10.1074/Jbc.M005381200 |
0.415 |
|
2000 |
Small KM, Forbes SL, Rahman FF, Bridges KM, Liggett SB. A four amino acid deletion polymorphism in the third intracellular loop of the human α(2C)-adrenergic receptor confers impaired coupling to multiple effectors Journal of Biological Chemistry. 275: 23059-23064. PMID 10801795 DOI: 10.1074/Jbc.M000796200 |
0.433 |
|
2000 |
Wagoner LE, Craft LL, Singh B, Suresh DP, Zengel PW, McGuire N, Abraham WT, Chenier TC, Dorn GW, Liggett SB. Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure. Circulation Research. 86: 834-40. PMID 10785504 DOI: 10.1161/01.Res.86.8.834 |
0.352 |
|
2000 |
Liggett SB, Tepe NM, Lorenz JN, Canning AM, Jantz TD, Mitarai S, Yatani A, Dorn GW. Early and delayed consequences of β2-adrenergic receptor overexpression in mouse hearts: Critical role for expression level Circulation. 101: 1707-1714. PMID 10758054 DOI: 10.1161/01.Cir.101.14.1707 |
0.372 |
|
2000 |
Liggett SB. beta(2)-adrenergic receptor pharmacogenetics. American Journal of Respiratory and Critical Care Medicine. 161: S197-201. PMID 10712374 DOI: 10.1164/Ajrccm.161.Supplement_2.A1Q4-10 |
0.443 |
|
2000 |
Tepe NM, Liggett SB. Functional receptor coupling to Gi is a mechanism of agonist-promoted desensitization of the beta2-adrenergic receptor. Journal of Receptor and Signal Transduction Research. 20: 75-85. PMID 10711498 DOI: 10.3109/10799890009150038 |
0.481 |
|
2000 |
Small KM, Forbes SL, Rahman FF, Liggett SB. Fusion of beta 2-adrenergic receptor to G alpha s in mammalian cells: identification of a specific signal transduction species not characteristic of constitutive activation or precoupling. Biochemistry. 39: 2815-21. PMID 10704234 DOI: 10.1021/Bi992497Z |
0.434 |
|
2000 |
Hoit BD, Suresh DP, Craft L, Walsh RA, Liggett SB. beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals. American Heart Journal. 139: 537-42. PMID 10689270 DOI: 10.1016/S0002-8703(00)90099-1 |
0.448 |
|
2000 |
Liggett SB. The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma. The Journal of Allergy and Clinical Immunology. 105: S487-92. PMID 10669529 DOI: 10.1016/S0091-6749(00)90048-4 |
0.423 |
|
2000 |
Liggett SB. Plastic adenylyl cyclase. American Journal of Respiratory Cell and Molecular Biology. 21: 564-6. PMID 10536115 DOI: 10.1165/Ajrcmb.21.5.F175 |
0.447 |
|
1999 |
Tepe NM, Lorenz JN, Yatani A, Dash R, Kranias EG, Dorn GW, Liggett SB. Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling. Biochemistry. 38: 16706-13. PMID 10600134 DOI: 10.1021/Bi991619K |
0.404 |
|
1999 |
McGraw DW, Forbes SL, Kramer LA, Witte DP, Fortner CN, Paul RJ, Liggett SB. Transgenic overexpression of beta(2)-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity. The Journal of Biological Chemistry. 274: 32241-7. PMID 10542262 DOI: 10.1074/Jbc.274.45.32241 |
0.437 |
|
1999 |
Tepe NM, Liggett SB. Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse. Febs Letters. 458: 236-40. PMID 10481072 DOI: 10.1016/S0014-5793(99)01147-3 |
0.366 |
|
1999 |
Moore JD, Mason DA, Green SA, Hsu J, Liggett SB. Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C Human Mutation. 14: 271. PMID 10477438 DOI: 10.1002/(Sici)1098-1004(1999)14:3<271::Aid-Humu14>3.0.Co;2-Q |
0.399 |
|
1999 |
Liggett SB. Molecular and genetic basis of beta2-adrenergic receptor function. The Journal of Allergy and Clinical Immunology. 104: S42-6. PMID 10452787 DOI: 10.1016/S0091-6749(99)70272-1 |
0.5 |
|
1999 |
Small K, Feng JF, Lorenz J, Donnelly ET, Yu A, Im MJ, Dorn GW, Liggett SB. Cardiac specific overexpression of transglutaminase II (G(h)) results in a unique hypertrophy phenotype independent of phospholipase C activation. The Journal of Biological Chemistry. 274: 21291-6. PMID 10409687 DOI: 10.1074/Jbc.274.30.21291 |
0.439 |
|
1999 |
Dorn GW, Tepe NM, Lorenz JN, Koch WJ, Liggett SB. Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 6400-5. PMID 10339599 DOI: 10.1073/Pnas.96.11.6400 |
0.547 |
|
1999 |
Mason DA, Moore JD, Green SA, Liggett SB. A gain-of-function polymorphism in a G-protein coupling domain of the human β1-adrenergic receptor Journal of Biological Chemistry. 274: 12670-12674. PMID 10212248 DOI: 10.1074/jbc.274.18.12670 |
0.379 |
|
1999 |
Wagoner LE, Craft LL, Abraham WT, Zengel PW, Hornung RW, Liggett SB. The Ile164 β2-adrenergic receptor polymorphism is associated with decreased exercise capacity in patients with heart failure Journal of Cardiac Failure. 5: 52. DOI: 10.1016/S1071-9164(99)91537-3 |
0.384 |
|
1998 |
Jewell-Motz EA, Donnelly ET, Eason MG, Liggett SB. Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation. Biochemistry. 37: 15720-5. PMID 9843377 DOI: 10.1021/Bi980999R |
0.466 |
|
1998 |
McGraw DW, Forbes SL, Kramer LA, Liggett SB. Polymorphisms of the 5' leader cistron of the human β2-adrenergic receptor regulate receptor expression Journal of Clinical Investigation. 102: 1927-1932. PMID 9835617 DOI: 10.1172/Jci4862 |
0.385 |
|
1998 |
Liggett SB, Wagoner LE, Craft LL, Hornung RW, Hoit BD, McIntosh TC, Walsh RA. The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. The Journal of Clinical Investigation. 102: 1534-9. PMID 9788966 DOI: 10.1172/Jci4059 |
0.373 |
|
1998 |
Weir TD, Mallek N, Sandford AJ, Bai TR, Awadh N, Fitzgerald JM, Cockcroft D, James A, Liggett SB, Paré PD. beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. American Journal of Respiratory and Critical Care Medicine. 158: 787-91. PMID 9731005 DOI: 10.1164/Ajrccm.158.3.9801035 |
0.371 |
|
1998 |
Adams JW, Sakata Y, Davis MG, Sah VP, Wang Y, Liggett SB, Chien KR, Brown JH, Dorn GW. Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proceedings of the National Academy of Sciences of the United States of America. 95: 10140-5. PMID 9707614 DOI: 10.1073/Pnas.95.17.10140 |
0.334 |
|
1998 |
Liang M, Eason MG, Jewell-Motz EA, Williams MA, Theiss CT, Dorn GW, Liggett SB. Phosphorylation and functional desensitization of the alpha2A-adrenergic receptor by protein kinase C. Molecular Pharmacology. 54: 44-9. PMID 9658188 DOI: 10.1124/Mol.54.1.44 |
0.699 |
|
1998 |
McGraw DW, Donnelly ET, Eason MG, Green SA, Liggett SB. Role of beta ARK in long-term agonist-promoted desensitisation of the beta 2-adrenergic receptor. Cellular Signalling. 10: 197-204. PMID 9607143 DOI: 10.1016/S0898-6568(97)00112-5 |
0.43 |
|
1998 |
Sakata Y, Hoit BD, Liggett SB, Walsh RA, Dorn GW. Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. Circulation. 97: 1488-95. PMID 9576430 DOI: 10.1161/01.Cir.97.15.1488 |
0.311 |
|
1997 |
Liggett SB. Polymorphisms of the beta2-adrenergic receptor and asthma. American Journal of Respiratory and Critical Care Medicine. 156: S156-62. PMID 9351598 DOI: 10.1164/Ajrccm.156.4.12Tac-15 |
0.443 |
|
1997 |
Liggett SB. Structural determinants of alpha 2-adrenergic receptor regulation. Advances in Pharmacology (San Diego, Calif.). 42: 438-42. PMID 9327933 DOI: 10.1016/S1054-3589(08)60782-6 |
0.457 |
|
1997 |
D'Angelo DD, Sakata Y, Lorenz JN, Boivin GP, Walsh RA, Liggett SB, Dorn GW. Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 8121-6. PMID 9223325 DOI: 10.1073/Pnas.94.15.8121 |
0.402 |
|
1997 |
Jewell-Motz EA, Donnelly ET, Eason MG, Liggett SB. Role of the amino terminus of the third intracellular loop in agonist-promoted downregulation of the alpha2A-adrenergic receptor. Biochemistry. 36: 8858-63. PMID 9220972 DOI: 10.1021/Bi970487X |
0.478 |
|
1997 |
Kiss E, Edes I, Sato Y, Luo W, Liggett SB, Kranias EG. beta-Adrenergic regulation of cAMP and protein phosphorylation in phospholamban-knockout mouse hearts. The American Journal of Physiology. 272: H785-90. PMID 9124439 DOI: 10.1152/Ajpheart.1997.272.2.H785 |
0.429 |
|
1997 |
McGraw DW, Liggett SB. Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor. The Journal of Biological Chemistry. 272: 7338-44. PMID 9054432 DOI: 10.1074/Jbc.272.11.7338 |
0.417 |
|
1996 |
Turki J, Lorenz JN, Green SA, Donnelly ET, Jacinto M, Liggett SB. Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 93: 10483-8. PMID 8816827 DOI: 10.1073/Pnas.93.19.10483 |
0.452 |
|
1996 |
Green SA, Spasoff AP, Coleman RA, Johnson M, Liggett SB. Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor. The Journal of Biological Chemistry. 271: 24029-35. PMID 8798639 DOI: 10.1074/Jbc.271.39.24029 |
0.438 |
|
1996 |
Jewell-Motz EA, Liggett SB. G protein-coupled receptor kinase specificity for phosphorylation and desensitization of alpha2-adrenergic receptor subtypes. The Journal of Biological Chemistry. 271: 18082-7. PMID 8663433 DOI: 10.1074/Jbc.271.30.18082 |
0.433 |
|
1996 |
Eason MG, Liggett SB. Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains. The Journal of Biological Chemistry. 271: 12826-32. PMID 8662784 DOI: 10.1074/Jbc.271.22.12826 |
0.314 |
|
1996 |
Liggett SB. Genetics of beta 2-adrenergic receptor variants in asthma. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 89-94; discussion 95. PMID 8590354 DOI: 10.1111/J.1365-2222.1995.Tb00431.X |
0.411 |
|
1995 |
Green SA, Turki J, Hall IP, Liggett SB. Implications of genetic variability of human β2-adrenergic receptor structure Pulmonary Pharmacology. 8: 1-10. PMID 8535093 DOI: 10.1006/Pulp.1995.1001 |
0.383 |
|
1995 |
Eason MG, Moreira SP, Liggett SB. Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor. The Journal of Biological Chemistry. 270: 4681-8. PMID 7876239 DOI: 10.1074/Jbc.270.9.4681 |
0.479 |
|
1995 |
Turki J, Liggett SB. Receptor-specific functional properties of beta 2-adrenergic receptor autoantibodies in asthma. American Journal of Respiratory Cell and Molecular Biology. 12: 531-9. PMID 7742016 DOI: 10.1165/Ajrcmb.12.5.7742016 |
0.433 |
|
1995 |
Hall IP, Wheatley A, Wilding P, Liggett SB. Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet (London, England). 345: 1213-4. PMID 7739309 DOI: 10.1016/S0140-6736(95)91994-5 |
0.419 |
|
1995 |
Turki J, Pak J, Green SA, Martin RJ, Liggett SB. Genetic polymorphisms of the β2-adrenergic receptor in nocturnal and nonnocturnal asthma: Evidence that Gly16 correlates with the nocturnal phenotype Journal of Clinical Investigation. 95: 1635-1641. PMID 7706471 DOI: 10.1172/Jci117838 |
0.356 |
|
1995 |
Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, Lefkowitz RJ. Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. The Journal of Biological Chemistry. 270: 17953-61. PMID 7629102 DOI: 10.1074/Jbc.270.30.17953 |
0.789 |
|
1995 |
Liggett SB, Levi R, Metzger H. G-protein coupled receptors, nitric oxide, and the IgE receptor in asthma. American Journal of Respiratory and Critical Care Medicine. 152: 394-402. PMID 7599854 DOI: 10.1164/Ajrccm.152.1.7599854 |
0.451 |
|
1995 |
Green SA, Turki J, Bejarano P, Hall IP, Liggett SB. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells American Journal of Respiratory Cell and Molecular Biology. 13: 25-33. PMID 7598936 DOI: 10.1165/Ajrcmb.13.1.7598936 |
0.449 |
|
1995 |
Eason MG, Liggett SB. Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling. The Journal of Biological Chemistry. 270: 24753-60. PMID 7559592 DOI: 10.1074/Jbc.270.42.24753 |
0.371 |
|
1995 |
Jewell-Motz EA, Liggett SB. An acidic motif within the third intracellular loop of the alpha2C2 adrenergic receptor is required for agonist-promoted phosphorylation and desensitization. Biochemistry. 34: 11946-53. PMID 7547931 DOI: 10.1021/Bi00037A036 |
0.447 |
|
1995 |
Turki J, Green SA, Newman KB, Meyers MA, Liggett SB. Human lung cell beta 2-adrenergic receptors desensitize in response to in vivo administered beta-agonist. The American Journal of Physiology. 269: L709-14. PMID 7491992 DOI: 10.1152/Ajplung.1995.269.5.L709 |
0.425 |
|
1994 |
Eason MG, Jacinto MT, Theiss CT, Liggett SB. The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation. Proceedings of the National Academy of Sciences of the United States of America. 91: 11178-82. PMID 7972030 DOI: 10.1073/Pnas.91.23.11178 |
0.362 |
|
1994 |
Green SA, Turki J, Innis M, Liggett SB. Amino-terminal polymorphisms of the human β2-adrenergic receptor impart distinct agonist-promoted regulatory properties Biochemistry. 33: 9414-9419. PMID 7915137 DOI: 10.1021/Bi00198A006 |
0.461 |
|
1993 |
Liggett SB, Raymond JR. Pharmacology and molecular biology of adrenergic receptors. Bailliere's Clinical Endocrinology and Metabolism. 7: 279-306. PMID 8489482 DOI: 10.1016/S0950-351X(05)80178-8 |
0.452 |
|
1993 |
Liggett SB, Freedman NJ, Schwinn DA, Lefkowitz RJ. Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 90: 3665-9. PMID 8386380 DOI: 10.1073/Pnas.90.8.3665 |
0.784 |
|
1993 |
Reihsaus E, Innis M, MacIntyre N, Liggett SB. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. American Journal of Respiratory Cell and Molecular Biology. 8: 334-9. PMID 8383511 DOI: 10.1165/Ajrcmb/8.3.334 |
0.37 |
|
1992 |
Liggett SB. Desensitization of the beta-adrenergic receptor: distinct molecular determinants of phosphorylation by specific kinases. Pharmacological Research. 29-41. PMID 1661007 DOI: 10.1016/1043-6618(91)90119-I |
0.434 |
|
1992 |
Thomas RF, Holt BD, Schwinn DA, Liggett SB. Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements. Proceedings of the National Academy of Sciences of the United States of America. 89: 4490-4. PMID 1374904 DOI: 10.1073/Pnas.89.10.4490 |
0.634 |
|
1992 |
Kraus WE, Longabaugh JP, Liggett SB. Electrical pacing induces adenylyl cyclase in skeletal muscle independent of the beta-adrenergic receptor. The American Journal of Physiology. 263: E226-30. PMID 1325124 DOI: 10.1152/Ajpendo.1992.263.2.E226 |
0.386 |
|
1992 |
Saffitz JE, Liggett SB. Subcellular distribution of beta 2-adrenergic receptors delineated with quantitative ultrastructural autoradiography of radioligand binding sites. Circulation Research. 70: 1320-5. PMID 1315641 DOI: 10.1161/01.Res.70.6.1320 |
0.473 |
|
1991 |
Liggett SB, Schwinn DA. Multiple potential regulatory elements in the 5' flanking region of the beta 3-adrenergic receptor. Dna Sequence : the Journal of Dna Sequencing and Mapping. 2: 61-3. PMID 1666313 DOI: 10.3109/10425179109008441 |
0.627 |
|
1991 |
Schwinn DA, Leone BJ, Spahn DR, Chesnut LC, Page SO, McRae RL, Liggett SB. Desensitization of myocardial beta-adrenergic receptors during cardiopulmonary bypass. Evidence for early uncoupling and late downregulation. Circulation. 84: 2559-67. PMID 1659956 DOI: 10.1161/01.Cir.84.6.2559 |
0.626 |
|
1991 |
Schwinn DA, Leone BJ, Chesnut LC, Spahn DR, Page SO, Liggett SB. β-ADRENERGIC RECEPTOR DESENSITIZATION DURING CARDIOPULMONARY BYPASS Anesthesiology. 75: A1119. DOI: 10.1097/00000542-199109001-01118 |
0.634 |
|
1989 |
Liggett SB. Identification and characterization of a homogeneous population of beta 2-adrenergic receptors on human alveolar macrophages. The American Review of Respiratory Disease. 139: 552-5. PMID 2563322 DOI: 10.1164/Ajrccm/139.2.552 |
0.455 |
|
1989 |
Liggett SB, Bouvier M, O'Dowd BF, Caron MG, Lefkowitz RJ, DeBlasi A. Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. Biochemical and Biophysical Research Communications. 165: 257-63. PMID 2556136 DOI: 10.1016/0006-291X(89)91063-2 |
0.801 |
|
1989 |
Liggett SB. Beta-adrenoceptor-effector system of the human macrophage U937 cell line. European Journal of Pharmacology. 163: 171-4. PMID 2545462 DOI: 10.1016/0014-2999(89)90414-7 |
0.409 |
|
1989 |
Liggett SB, Shah SD, Cryer PE. Human tissue adrenergic receptors are not predictive of responses to epinephrine in vivo. The American Journal of Physiology. 256: E600-9. PMID 2541622 DOI: 10.1152/Ajpendo.1989.256.5.E600 |
0.456 |
|
1989 |
Liggett SB, Shah SD, Cryer PE. Increased fat and skeletal muscle beta-adrenergic receptors but unaltered metabolic and hemodynamic sensitivity to epinephrine in vivo in experimental human thyrotoxicosis. The Journal of Clinical Investigation. 83: 803-9. PMID 2537849 DOI: 10.1172/Jci113961 |
0.405 |
|
1988 |
Liggett SB, Marker JC, Shah SD, Roper CL, Cryer PE. Direct relationship between mononuclear leukocyte and lung beta-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha- and beta-adrenergic receptors by the sympathochromaffin system in humans. The Journal of Clinical Investigation. 82: 48-56. PMID 2839552 DOI: 10.1172/Jci113600 |
0.438 |
|
1988 |
Liggett SB, Shah SD, Cryer PE. Characterization of beta-adrenergic receptors of human skeletal muscle obtained by needle biopsy. The American Journal of Physiology. 254: E795-8. PMID 2837096 DOI: 10.1152/Ajpendo.1988.254.6.E795 |
0.442 |
|
Show low-probability matches. |