| Year |
Citation |
Score |
| 2022 |
Yuan Y, Du L, Tan R, Yu Y, Jiang J, Yao A, Luo J, Tang R, Xiao Y, Sun H. Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL. Journal of Medicinal Chemistry. 65: 7770-7785. PMID 35612819 DOI: 10.1021/acs.jmedchem.2c00083 |
0.337 |
|
| 2019 |
Ma Z, Gao G, Fang K, Sun H. Development of Novel Anticancer Agents with a Scaffold of Tetrahydropyrido[4,3-]pyrimidine-2,4-dione. Acs Medicinal Chemistry Letters. 10: 191-195. PMID 30783502 DOI: 10.1021/acsmedchemlett.8b00531 |
0.365 |
|
| 2014 |
Sun H, Lu J, Liu L, Yang CY, Wang S. Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells. Acs Chemical Biology. 9: 994-1002. PMID 24521431 DOI: 10.1021/Cb400889A |
0.422 |
|
| 2013 |
Sheng R, Sun H, Liu L, Lu J, McEachern D, Wang G, Wen J, Min P, Du Z, Lu H, Kang S, Guo M, Yang D, Wang S. A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. Journal of Medicinal Chemistry. 56: 3969-79. PMID 23651223 DOI: 10.1021/Jm400216D |
0.459 |
|
| 2012 |
Wang S, Bai L, Lu J, Liu L, Yang CY, Sun H. Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics. Journal of Mammary Gland Biology and Neoplasia. 17: 217-28. PMID 23054134 DOI: 10.1007/S10911-012-9265-1 |
0.418 |
|
| 2012 |
Bai L, McEachern D, Yang CY, Lu J, Sun H, Wang S. LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling. Cancer Research. 72: 1229-38. PMID 22241084 DOI: 10.1158/0008-5472.Can-11-2428 |
0.414 |
|
| 2012 |
Peng Y, Sun H, Lu J, Liu L, Cai Q, Shen R, Yang CY, Yi H, Wang S. Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents. Journal of Medicinal Chemistry. 55: 106-14. PMID 22148838 DOI: 10.1021/Jm201072X |
0.609 |
|
| 2011 |
Sun H, Liu L, Lu J, Bai L, Li X, Nikolovska-Coleska Z, McEachern D, Yang CY, Qiu S, Yi H, Sun D, Wang S. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. Journal of Medicinal Chemistry. 54: 3306-18. PMID 21462933 DOI: 10.1021/Jm101651B |
0.515 |
|
| 2011 |
Cai Q, Sun H, Peng Y, Lu J, Nikolovska-Coleska Z, McEachern D, Liu L, Qiu S, Yang CY, Miller R, Yi H, Zhang T, Sun D, Kang S, Guo M, et al. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. Journal of Medicinal Chemistry. 54: 2714-26. PMID 21443232 DOI: 10.1021/Jm101505D |
0.608 |
|
| 2011 |
Lu J, McEachern D, Sun H, Bai L, Peng Y, Qiu S, Miller R, Liao J, Yi H, Liu M, Bellail A, Hao C, Sun SY, Ting AT, Wang S. Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment. Molecular Cancer Therapeutics. 10: 902-14. PMID 21372226 DOI: 10.1158/1535-7163.Mct-10-0864 |
0.428 |
|
| 2011 |
Yang J, McEachern D, Li W, Davis MA, Li H, Morgan MA, Bai L, Sebolt JT, Sun H, Lawrence TS, Wang S, Sun Y. Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases. Molecular Cancer Therapeutics. 10: 658-69. PMID 21282353 DOI: 10.1158/1535-7163.Mct-10-0643 |
0.429 |
|
| 2011 |
Sun H, Lu J, Liu L, McEachern D, Bai L, Yang C, Wang S. Abstract 3254: Novel bivalent Smac mimetics as a new class of anticancer agents Cancer Research. 71: 3254-3254. DOI: 10.1158/1538-7445.Am2011-3254 |
0.508 |
|
| 2010 |
Sun H, Lu J, Liu L, Yi H, Qiu S, Yang CY, Deschamps JR, Wang S. Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. Journal of Medicinal Chemistry. 53: 6361-7. PMID 20684551 DOI: 10.1021/Jm100487Z |
0.526 |
|
| 2010 |
Sun H, Liu L, Lu J, Qiu S, Yang CY, Yi H, Wang S. Cyclopeptide Smac mimetics as antagonists of IAP proteins. Bioorganic & Medicinal Chemistry Letters. 20: 3043-6. PMID 20443226 DOI: 10.1016/J.Bmcl.2010.03.114 |
0.494 |
|
| 2009 |
Sun W, Nikolovska-Coleska Z, Qin D, Sun H, Yang CY, Bai L, Qiu S, Wang Y, Ma D, Wang S. Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. Journal of Medicinal Chemistry. 52: 593-6. PMID 19138149 DOI: 10.1021/Jm801101Z |
0.622 |
|
| 2008 |
Peng Y, Sun H, Nikolovska-Coleska Z, Qiu S, Yang CY, Lu J, Cai Q, Yi H, Kang S, Yang D, Wang S. Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases. Journal of Medicinal Chemistry. 51: 8158-62. PMID 19049347 DOI: 10.1021/Jm801254R |
0.612 |
|
| 2008 |
Zhang B, Nikolovska-Coleska Z, Zhang Y, Bai L, Qiu S, Yang CY, Sun H, Wang S, Wu Y. Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases. Journal of Medicinal Chemistry. 51: 7352-5. PMID 19012392 DOI: 10.1021/Jm801146D |
0.529 |
|
| 2008 |
Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, Miller RS, Yi H, Shangary S, Sun Y, Meagher JL, Stuckey JA, Wang S. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Research. 68: 9384-93. PMID 19010913 DOI: 10.1158/0008-5472.Can-08-2655 |
0.402 |
|
| 2008 |
Sun H, Stuckey JA, Nikolovska-Coleska Z, Qin D, Meagher JL, Qiu S, Lu J, Yang CY, Saito NG, Wang S. Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP). Journal of Medicinal Chemistry. 51: 7169-80. PMID 18954041 DOI: 10.1021/Jm8006849 |
0.465 |
|
| 2008 |
Sun H, Nikolovska-Coleska Z, Yang CY, Qian D, Lu J, Qiu S, Bai L, Peng Y, Cai Q, Wang S. Design of small-molecule peptidic and nonpeptidic Smac mimetics. Accounts of Chemical Research. 41: 1264-77. PMID 18937395 DOI: 10.1021/Ar8000553 |
0.555 |
|
| 2007 |
Sun H, Nikolovska-Coleska Z, Lu J, Meagher JL, Yang CY, Qiu S, Tomita Y, Ueda Y, Jiang S, Krajewski K, Roller PP, Stuckey JA, Wang S. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP. Journal of the American Chemical Society. 129: 15279-94. PMID 17999504 DOI: 10.1021/Ja074725F |
0.439 |
|
| 2006 |
Sun H, Nikolovska-Coleska Z, Lu J, Qiu S, Yang CY, Gao W, Meagher J, Stuckey J, Wang S. Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic. Journal of Medicinal Chemistry. 49: 7916-20. PMID 17181177 DOI: 10.1021/Jm061108D |
0.521 |
|
| 2006 |
Peng Y, Sun H, Wang S. Design and synthesis of a 1,5-diazabicyclo[6,3,0] dodecane amino acid derivative as a novel dipeptide reverse-turn mimetic Tetrahedron Letters. 47: 4769-4770. DOI: 10.1016/J.Tetlet.2006.04.053 |
0.325 |
|
| 2005 |
Sun H, Nikolovska-Coleska Z, Chen J, Yang CY, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics. Bioorganic & Medicinal Chemistry Letters. 15: 793-7. PMID 15664859 DOI: 10.1016/J.Bmcl.2004.11.008 |
0.492 |
|
| 2005 |
Sun H, Nikolovska-Coleska Z, Yang CY, Wang S. Design and synthesis of a potent biotinylated Smac mimetic Tetrahedron Letters. 46: 7015-7018. DOI: 10.1016/J.Tetlet.2005.08.055 |
0.393 |
|
| 2004 |
Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Liu M, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Structure-based design of potent, conformationally constrained Smac mimetics. Journal of the American Chemical Society. 126: 16686-7. PMID 15612682 DOI: 10.1021/Ja047438+ |
0.443 |
|
| 2004 |
Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Tomita Y, Krajewski K, Roller PP, Wang S. Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site. Journal of Medicinal Chemistry. 47: 4147-50. PMID 15293984 DOI: 10.1021/Jm0499108 |
0.435 |
|
| 2004 |
Saito NG, Sun H, Nikolovska-Coleska Z, Xu L, Stuckey JA, Lawrence TS, Wang S. Use of smac peptidomimetic compounds as effective radiosensitizers of human cancer cell lines International Journal of Radiation Oncology Biology Physics. 60. DOI: 10.1016/J.Ijrobp.2004.07.199 |
0.457 |
|
| 2003 |
Kozikowski AP, Sun H, Brognard J, Dennis PA. Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt Journal of the American Chemical Society. 125: 1144-1145. PMID 12553797 DOI: 10.1021/Ja0285159 |
0.538 |
|
| 2002 |
Sun H, Bapu Reddy G, George C, Meuillet EJ, Berggren M, Powis G, Kozikowski AP. Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues Tetrahedron Letters. 43: 2835-2838. DOI: 10.1016/S0040-4039(02)00354-4 |
0.562 |
|
| 2000 |
Ma D, Sun H. A simple and stereospecfic route to 2,6-disubstituted 4-hydroxypiperidines. Synthesis of dendrobate alkaloid (+)-241D and formal synthesis of (-)-indolizidine 167B. Organic Letters. 2: 2503-5. PMID 10956532 DOI: 10.1021/Ol006176N |
0.441 |
|
| 2000 |
Ma D, Sun H. Total synthesis of (2S,3S,4R)-plakoridine A Tetrahedron Letters. 41: 1947-1950. DOI: 10.1016/S0040-4039(00)00096-4 |
0.447 |
|
| 1999 |
Ma D, Sun H. Diastereoselective synthesis of 2,4,5-trisubstituted piperidines from enantiopure β-amino esters Tetrahedron Letters. 40: 3609-3612. DOI: 10.1016/S0040-4039(99)00537-7 |
0.443 |
|
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