Richard Klinghoffer - Publications

Affiliations: 
1998-2001 Fred Hutchinson Cancer Research Center, Seattle, WA, United States 
 2010- Presage Biosciences 

16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Morris SM, Mhyre AJ, Carmack SS, Myers CH, Burns C, Ye W, Ferrer M, Olson JM, Klinghoffer RA. A modified gene trap approach for improved high-throughput cancer drug discovery. Oncogene. PMID 29717260 DOI: 10.1038/S41388-018-0274-4  0.317
2012 Berndt JD, Frazier J, Grenley M, Bahrami B, Moon RT, Olson J, Klinghoffer R. Abstract 5116: Identification and rapidin vivovalidation of a novel drug combination for treating melanoma Cancer Research. 72: 5116-5116. DOI: 10.1158/1538-7445.Am2012-5116  0.35
2010 Andersen JN, Sathyanarayanan S, Di Bacco A, Chi A, Zhang T, Chen AH, Dolinski B, Kraus M, Roberts B, Arthur W, Klinghoffer RA, Gargano D, Li L, Feldman I, Lynch B, et al. Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors. Science Translational Medicine. 2: 43ra55. PMID 20686178 DOI: 10.1126/Scitranslmed.3001065  0.347
2003 Hamilton TG, Klinghoffer RA, Corrin PD, Soriano P. Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms Molecular and Cellular Biology. 23: 4013-4025. PMID 12748302 DOI: 10.1128/Mcb.23.11.4013-4025.2003  0.682
2002 Cary LA, Klinghoffer RA, Sachsenmaier C, Cooper JA. Src catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading Molecular and Cellular Biology. 22: 2427-2440. PMID 11909938 DOI: 10.1128/MCB.22.8.2427-2440.2002  0.452
2002 Klinghoffer RA, Hamilton TG, Hoch R, Soriano P. An allelic series at the PDGFαR locus indicates unequal contributions of distinct signaling pathways during development Developmental Cell. 2: 103-113. PMID 11782318 DOI: 10.1016/S1534-5807(01)00103-4  0.647
2001 Klinghoffer RA, Mueting-Nelsen PF, Faerman A, Shani M, Soriano P. The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions Molecular Cell. 7: 343-354. PMID 11239463 DOI: 10.1016/S1097-2765(01)00182-4  0.643
2000 Tallquist MD, Klinghoffer RA, Heuchel R, Mueting-Nelsen PF, Corrin PD, Heldin CH, Johnson RJ, Soriano P. Retention of PDGFR-β function in mice in the absence of phosphatidylinositol 3′-kinase anti phospholipase Cγ signaling pathways Genes and Development. 14: 3179-3190. PMID 11124809 DOI: 10.1101/Gad.844700  0.667
2000 Rosenkranz S, Ikuno Y, Leong FL, Klinghoffer RA, Miyake S, Band H, Kazlauskas A. Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression. The Journal of Biological Chemistry. 275: 9620-7. PMID 10734113 DOI: 10.1074/jbc.275.13.9620  0.395
1999 Tallquist MD, Soriano P, Klinghoffer RA. Growth factor signaling pathways in vascular development Oncogene. 18: 7917-7932. PMID 10630644 DOI: 10.1038/Sj.Onc.1203216  0.68
1999 Davy A, Gale NW, Murray EW, Klinghoffer RA, Soriano P, Feuerstein C, Robbins SM. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes & Development. 13: 3125-35. PMID 10601038 DOI: 10.1101/Gad.13.23.3125  0.676
1999 Jones SM, Klinghoffer R, Prestwich GD, Toker A, Kazlauskas A. PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Current Biology : Cb. 9: 512-21. PMID 10339426 DOI: 10.1016/S0960-9822(99)80235-8  0.405
1999 Klinghoffer RA, Sachsenmaier C, Cooper JA, Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. The Embo Journal. 18: 2459-71. PMID 10228160 DOI: 10.1093/Emboj/18.9.2459  0.648
1996 Quon MJ, Chen H, Lin CH, Zhou L, Ing BL, Zarnowski MJ, Klinghoffer R, Kazlauskas A, Cushman SW, Taylor SI. Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells. Biochemical and Biophysical Research Communications. 226: 587-94. PMID 8831662 DOI: 10.1006/Bbrc.1996.1400  0.333
1996 Klinghoffer RA, Duckworth B, Valius M, Cantley L, Kazlauskas A. Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Molecular and Cellular Biology. 16: 5905-14. PMID 8816504 DOI: 10.1128/Mcb.16.10.5905  0.388
1995 Klinghoffer RA, Kazlauskas A. Identification of a putative Syp substrate, the PDGF beta receptor. The Journal of Biological Chemistry. 270: 22208-17. PMID 7545675 DOI: 10.1074/jbc.270.38.22208  0.356
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