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Kullervo Hynynen - Publications

Affiliations: 
Medical Biophysics University of Toronto, Toronto, ON, Canada 
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Year Citation  Score
2023 Kofoed RH, Simpson EM, Hynynen K, Aubert I. Sonoselective delivery using ultrasound and microbubbles combined with intravenous rAAV9 CLDN5-GFP does not increase endothelial gene expression. Gene Therapy. PMID 36781945 DOI: 10.1038/s41434-023-00389-y  0.562
2023 Gouveia FV, Lea-Banks H, Aubert I, Lipsman N, Hynynen K, Hamani C. Anesthetic-loaded nanodroplets with focused ultrasound reduces agitation in Alzheimer's mice. Annals of Clinical and Translational Neurology. PMID 36715553 DOI: 10.1002/acn3.51737  0.514
2023 Meng Y, Goubran M, Rabin JS, McSweeney M, Ottoy J, Pople CB, Huang Y, Storace A, Ozzoude M, Bethune A, Lam B, Swardfager W, Heyn C, Abrahao A, Davidson B, ... ... Hynynen K, et al. Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound. Brain : a Journal of Neurology. PMID 36694943 DOI: 10.1093/brain/awac459  0.592
2022 Huang Y, Meng Y, Pople CB, Bethune A, Jones RM, Abrahao A, Hamani C, Kalia SK, Kalia LV, Lipsman N, Hynynen K. Cavitation Feedback Control of Focused Ultrasound Blood-Brain Barrier Opening for Drug Delivery in Patients with Parkinson's Disease. Pharmaceutics. 14. PMID 36559101 DOI: 10.3390/pharmaceutics14122607  0.329
2022 Kofoed RH, Noseworthy K, Wu K, Sivadas S, Stanek L, Elmer B, Hynynen K, Shihabuddin LS, Aubert I. The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sites. Molecular Therapy. Methods & Clinical Development. 27: 167-184. PMID 36284767 DOI: 10.1016/j.omtm.2022.09.011  0.609
2022 Kofoed RH, Dibia CL, Noseworthy K, Xhima K, Vacaresse N, Hynynen K, Aubert I. Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas. Journal of Controlled Release : Official Journal of the Controlled Release Society. 351: 667-680. PMID 36179767 DOI: 10.1016/j.jconrel.2022.09.048  0.609
2022 Trinh D, Nash J, Goertz D, Hynynen K, Bulner S, Iqbal U, Keenan J. Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3. Drug Delivery. 29: 1176-1183. PMID 35393905 DOI: 10.1080/10717544.2022.2035855  0.32
2022 Poon C, Mühlenpfordt M, Olsman M, Kotopoulis S, de Lange Davies C, Hynynen K. Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability. Journal of Visualized Experiments : Jove. PMID 35188113 DOI: 10.3791/62235  0.33
2021 Xhima K, Markham-Coultes K, Kofoed RH, Saragovi HU, Hynynen K, Aubert I. Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies. Brain : a Journal of Neurology. PMID 34919633 DOI: 10.1093/brain/awab460  0.564
2021 Kofoed RH, Heinen S, Silburt J, Dubey S, Dibia CL, Maes M, Simpson EM, Hynynen K, Aubert I. Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis. Molecular Therapy. Methods & Clinical Development. 23: 390-405. PMID 34761053 DOI: 10.1016/j.omtm.2021.10.001  0.601
2021 Xhima K, McMahon D, Ntiri E, Goubran M, Hynynen K, Aubert I. Intravenous and Non-invasive Drug Delivery to the Mouse Basal ForebrainUsing MRI-guided Focused Ultrasound. Bio-Protocol. 11: e4056. PMID 34262999 DOI: 10.21769/BioProtoc.4056  0.601
2021 McMahon D, O'Reilly MA, Hynynen K. Therapeutic Agent Delivery Across the Blood-Brain Barrier Using Focused Ultrasound. Annual Review of Biomedical Engineering. PMID 33752471 DOI: 10.1146/annurev-bioeng-062117-121238  0.313
2021 Meng Y, Pople CB, Suppiah S, Llinas M, Huang Y, Sahgal A, Perry J, Keith J, Davidson B, Hamani C, Amemiya Y, Seth A, Leong H, Heyn CC, Aubert I, ... Hynynen K, et al. MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors. Neuro-Oncology. PMID 33693781 DOI: 10.1093/neuonc/noab057  0.577
2021 Weber-Adrian D, Kofoed RH, Silburt J, Noroozian Z, Shah K, Burgess A, Rideout S, Kügler S, Hynynen K, Aubert I. Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery. Scientific Reports. 11: 1934. PMID 33479314 DOI: 10.1038/s41598-021-81046-5  0.792
2021 Lynch M, Heinen S, Markham-Coultes K, O'Reilly M, Van Slyke P, Dumont DJ, Hynynen K, Aubert I. Vasculotide restores the blood-brain barrier after focused ultrasound-induced permeability in a mouse model of Alzheimer's disease. International Journal of Medical Sciences. 18: 482-493. PMID 33390817 DOI: 10.7150/ijms.36775  0.57
2020 Meng Y, Jones RM, Davidson B, Huang Y, Pople CB, Surendrakumar S, Hamani C, Hynynen K, Lipsman N. Technical Principles and Clinical Workflow of Transcranial MR-Guided Focused Ultrasound. Stereotactic and Functional Neurosurgery. 1-14. PMID 33302282 DOI: 10.1159/000512111  0.311
2020 Dubey S, Heinen S, Krantic S, McLaurin J, Branch DR, Hynynen K, Aubert I. Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 33288687 DOI: 10.1073/pnas.1908658117  0.603
2020 Rahimi S, Jones RM, Hynynen K. A High-Frequency Phased Array System for Transcranial Ultrasound Delivery in Small Animals. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. PMID 32746231 DOI: 10.1109/Tuffc.2020.3012868  0.337
2020 Jones RM, McMahon D, Hynynen K. Ultrafast three-dimensional microbubble imaging predicts tissue damage volume distributions during nonthermal brain ablation. Theranostics. 10: 7211-7230. PMID 32641988 DOI: 10.7150/Thno.47281  0.447
2020 Pellow C, O'Reilly MA, Hynynen K, Zheng G, Goertz DE. Simultaneous Intravital Optical and Acoustic Monitoring of Ultrasound-Triggered Nanobubble Generation and Extravasation. Nano Letters. PMID 32374617 DOI: 10.1021/Acs.Nanolett.0C01310  0.361
2020 Touahri Y, Dixit R, Kofoed RH, Miloska K, Park E, Raeisossadati R, Markham-Coultes K, David LA, Rijal H, Zhao J, Lynch M, Hynynen K, Aubert I, Schuurmans C. Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia. Theranostics. 10: 2982-2999. PMID 32194850 DOI: 10.7150/Thno.42611  0.618
2020 Lea-Banks H, O'Reilly MA, Hamani C, Hynynen K. Localized anesthesia of a specific brain region using ultrasound-responsive barbiturate nanodroplets. Theranostics. 10: 2849-2858. PMID 32194839 DOI: 10.7150/Thno.41566  0.394
2020 Kooiman K, Roovers S, Langeveld SAG, Kleven RT, Dewitte H, O'Reilly MA, Escoffre JM, Bouakaz A, Verweij MD, Hynynen K, Lentacker I, Stride E, Holland CK. Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery. Ultrasound in Medicine & Biology. PMID 32165014 DOI: 10.1016/J.Ultrasmedbio.2020.01.002  0.376
2020 McMahon D, Oakden W, Hynynen K. Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure. Theranostics. 10: 1604-1618. PMID 32042325 DOI: 10.7150/Thno.40908  0.392
2020 Xhima K, Markham-Coultes K, Nedev H, Heinen S, Saragovi HU, Hynynen K, Aubert I. Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease. Science Advances. 6: eaax6646. PMID 32010781 DOI: 10.1126/Sciadv.Aax6646  0.595
2020 Deng L, Hughes A, Hynynen K. A Noninvasive Ultrasound Resonance Method for Detecting Skull Induced Aberrations May Provide a Signal for Adaptive Focusing. Ieee Transactions On Bio-Medical Engineering. PMID 31976875 DOI: 10.1109/Tbme.2020.2967033  0.383
2020 Christensen-Jeffries K, Couture O, Dayton PA, Eldar YC, Hynynen K, Kiessling F, O'Reilly M, Pinton GF, Schmitz G, Tang MX, Tanter M, van Sloun RJG. Super-resolution Ultrasound Imaging. Ultrasound in Medicine & Biology. PMID 31973952 DOI: 10.1016/J.Ultrasmedbio.2019.11.013  0.341
2020 Bulner S, Prodeus A, Gariepy J, Hynynen K, Goertz DE. Abstract A20: Enhancing checkpoint inhibitor therapy with ultrasound stimulated microbubbles Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-A20  0.325
2019 Weber-Adrian D, Kofoed RH, Chan JWY, Silburt J, Noroozian Z, Kügler S, Hynynen K, Aubert I. Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease. Theranostics. 9: 8127-8137. PMID 31754385 DOI: 10.7150/Thno.36718  0.779
2019 Ranjan M, Elias GJB, Boutet A, Zhong J, Chu P, Germann J, Devenyi GA, Chakravarty MM, Fasano A, Hynynen K, Lipsman N, Hamani C, Kucharczyk W, Schwartz ML, Lozano AM, et al. Tractography-based targeting of the ventral intermediate nucleus: accuracy and clinical utility in MRgFUS thalamotomy. Journal of Neurosurgery. 1-8. PMID 31561221 DOI: 10.3171/2019.6.Jns19612  0.318
2019 Abrahao A, Meng Y, Llinas M, Huang Y, Hamani C, Mainprize T, Aubert I, Heyn C, Black SE, Hynynen K, Lipsman N, Zinman L. First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound. Nature Communications. 10: 4373. PMID 31558719 DOI: 10.1038/S41467-019-12426-9  0.614
2019 Meng Y, Abrahao A, Heyn CC, Bethune AJ, Huang Y, Pople C, Aubert I, Hamani C, Zinman L, Hynynen K, Black SE, Lipsman N. Glymphatics visualization after focused ultrasound induced blood-brain barrier opening in humans. Annals of Neurology. PMID 31525269 DOI: 10.1002/Ana.25604  0.62
2019 Meng Y, Pople CB, Lea-Banks H, Abrahao A, Davidson B, Suppiah S, Vecchio LM, Samuel N, Mahmud F, Hynynen K, Hamani C, Lipsman N. Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 31326464 DOI: 10.1016/J.Jconrel.2019.07.023  0.388
2019 Le Floc'h J, Lu HD, Lim TL, Démoré C, Prud'homme RK, Hynynen K, Foster FS. Transcranial Photoacoustic Detection of Blood-Brain Barrier Disruption Following Focused Ultrasound-Mediated Nanoparticle Delivery. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 31286352 DOI: 10.1007/S11307-019-01397-4  0.392
2019 Meng Y, MacIntosh BJ, Shirzadi Z, Kiss A, Bethune A, Heyn C, Mithani K, Hamani C, Black SE, Hynynen K, Lipsman N. Resting state functional connectivity changes after MR-guided focused ultrasound mediated blood-brain barrier opening in patients with Alzheimer's disease. Neuroimage. PMID 31254646 DOI: 10.1016/J.Neuroimage.2019.06.060  0.386
2019 Noroozian Z, Xhima K, Huang Y, Kaspar BK, Kügler S, Hynynen K, Aubert I. MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain. Methods in Molecular Biology (Clifton, N.J.). 1950: 177-197. PMID 30783974 DOI: 10.1007/978-1-4939-9139-6_10  0.648
2019 Mainprize T, Lipsman N, Huang Y, Meng Y, Bethune A, Ironside S, Heyn C, Alkins R, Trudeau M, Sahgal A, Perry J, Hynynen K. Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study. Scientific Reports. 9: 321. PMID 30674905 DOI: 10.1038/S41598-018-36340-0  0.427
2019 McMahon D, Poon C, Hynynen K. Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability. Expert Opinion On Drug Delivery. PMID 30628455 DOI: 10.1080/17425247.2019.1567490  0.414
2019 Perry K, Staruch R, Pichardo S, Huang Y, McGuffin M, Partanen A, Wong S, Czarnota GJ, Hynynen K, Chan KK, Chu W. Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) hyperthermia for primary rectal cancer: A virtual feasibility analysis. Journal of Global Oncology. 5: 77-77. DOI: 10.1200/Jgo.2019.5.Suppl.77  0.331
2019 Meng Y, MacIntosh BJ, Shirzadi Z, Kiss A, Bethune A, Heyn C, Mithani K, Hynynen K, Black SE, Lipsman N. Abstract #14: Resting State Functional Connectivity Changes After MR-Guided Focused Ultrasound Mediated Blood-Brain Barrier Opening Brain Stimulation. 12. DOI: 10.1016/J.Brs.2018.12.021  0.367
2018 Jones RM, Hynynen K. Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability. The British Journal of Radiology. 20180601. PMID 30507302 DOI: 10.1259/bjr.20180601  0.323
2018 Meng Y, Solomon B, Boutet A, Llinas M, Scantlebury N, Huang Y, Hynynen K, Hamani C, Fasano A, Lozano AM, Lipsman N, Schwartz ML. Magnetic resonance-guided focused ultrasound thalamotomy for treatment of essential tremor: A 2-year outcome study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30288794 DOI: 10.1002/Mds.99  0.3
2018 Xhima K, Nabbouh F, Hynynen K, Aubert I, Tandon A. Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30264465 DOI: 10.1002/Mds.101  0.554
2018 Poon CT, Shah K, Lin C, Tse R, Kim KK, Mooney S, Aubert I, Stefanovic B, Hynynen K. Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease. Scientific Reports. 8: 14061. PMID 30232364 DOI: 10.1038/S41598-018-32250-3  0.597
2018 McMahon D, Mah E, Hynynen K. Angiogenic response of rat hippocampal vasculature to focused ultrasound-mediated increases in blood-brain barrier permeability. Scientific Reports. 8: 12178. PMID 30111814 DOI: 10.1038/S41598-018-30825-8  0.37
2018 Huang Y, Lipsman N, Schwartz ML, Krishna V, Sammartino F, Lozano AM, Hynynen K. Predicting Lesion Size by Accumulated Thermal Dose in MR-Guided Focused Ultrasound for Essential Tremor. Medical Physics. PMID 30098027 DOI: 10.1002/Mp.13126  0.304
2018 O'Reilly MA, Hynynen K. Ultrasound and Microbubble-Mediated Blood-Brain Barrier Disruption for Targeted Delivery of Therapeutics to the Brain. Methods in Molecular Biology (Clifton, N.J.). 1831: 111-119. PMID 30051428 DOI: 10.1007/978-1-4939-8661-3_9  0.411
2018 Lipsman N, Meng Y, Bethune AJ, Huang Y, Lam B, Masellis M, Herrmann N, Heyn C, Aubert I, Boutet A, Smith GS, Hynynen K, Black SE. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound. Nature Communications. 9: 2336. PMID 30046032 DOI: 10.1038/S41467-018-04529-6  0.642
2018 Foroozan F, O'Reilly MA, Hynynen K. Microbubble Localization for 3D Super-Resolution Ultrasound Imaging Using Curve Fitting and Deconvolution Methods. Ieee Transactions On Bio-Medical Engineering. PMID 29993387 DOI: 10.1109/Tbme.2018.2813759  0.314
2018 O'Reilly MA, Chinnery T, Yee ML, Wu SK, Hynynen K, Kerbel RS, Czarnota GJ, Pritchard KI, Sahgal A. Preliminary Investigation of Focused Ultrasound-Facilitated Drug Delivery for the Treatment of Leptomeningeal Metastases. Scientific Reports. 8: 9013. PMID 29899537 DOI: 10.1038/S41598-018-27335-Y  0.344
2018 Jones RM, Deng L, Leung K, McMahon D, O'Reilly MA, Hynynen K. Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening. Theranostics. 8: 2909-2926. PMID 29896293 DOI: 10.7150/thno.24911  0.343
2018 Looi T, Piorkowska K, Mougenot C, Waspe A, Hynynen K, Drake J. An MR-based quantitative intraventricular hemorrhage porcine model for MR-guided focused ultrasound thrombolysis. Child's Nervous System : Chns : Official Journal of the International Society For Pediatric Neurosurgery. PMID 29796753 DOI: 10.1007/S00381-018-3816-8  0.306
2018 Hughes A, Huang Y, Schwartz ML, Hynynen K. The reduction in treatment efficiency at high acoustic powers during MR-guided transcranial focused ultrasound thalamotomy for Essential Tremor. Medical Physics. PMID 29758099 DOI: 10.1002/Mp.12975  0.32
2018 Alli S, Figueiredo CA, Golbourn B, Sabha N, Wu MY, Bondoc A, Luck A, Coluccia D, Maslink C, Smith C, Wurdak H, Hynynen K, O'Reilly M, Rutka JT. Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 29753957 DOI: 10.1016/J.Jconrel.2018.05.005  0.413
2018 McMahon D, Hynynen K. Reply to Kovacs .: Concerning acute inflammatory response following focused ultrasound and microbubbles in the brain. Theranostics. 8: 2249-2250. PMID 29722372 DOI: 10.7150/Thno.25468  0.331
2018 Coluccia D, Figueiredo CA, Wu MY, Riemenschneider AN, Diaz R, Luck A, Smith C, Das S, Ackerley C, O'Reilly M, Hynynen K, Rutka JT. Enhancing Glioblastoma Treatment using Cisplatin-Gold-Nanoparticle Conjugates and Targeted Delivery with Magnetic Resonance-Guided Focused Ultrasound. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 29471172 DOI: 10.1016/J.Nano.2018.01.021  0.381
2018 Mooney SJ, Nobrega JN, Levitt AJ, Hynynen K. Antidepressant effects of focused ultrasound induced blood-brain-barrier opening. Behavioural Brain Research. PMID 29326057 DOI: 10.1016/J.Bbr.2018.01.004  0.394
2018 O'Reilly MA, Jones RM, Deng L, Leung K, Fletcher SP, Xu R, Hynynen K. Advances in controlled transcranial bubble-mediated drug delivery and opportunities for transvertebral therapy The Journal of the Acoustical Society of America. 144: 1851-1851. DOI: 10.1121/1.5068147  0.402
2018 Acconcia C, Jones RM, Hynynen K. Treatment monitoring for sonothrombolysis in deep vein thrombosis: Receiver array design The Journal of the Acoustical Society of America. 144: 1699-1699. DOI: 10.1121/1.5067548  0.325
2018 Jones RM, O'Reilly MA, Deng L, Hynynen K. Biomedical applications of sparse hemispherical ultrasound arrays The Journal of the Acoustical Society of America. 143: 1871-1871. DOI: 10.1121/1.5036142  0.356
2018 Hynynen K. Progress in the utilization of focused ultrasound for treatment of the brain The Journal of the Acoustical Society of America. 143: 1730-1730. DOI: 10.1121/1.5035642  0.436
2017 McMahon D, Hynynen K. Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose. Theranostics. 7: 3989-4000. PMID 29109793 DOI: 10.7150/Thno.21630  0.378
2017 Liu M, Jevtic S, Markham-Coultes K, Ellens NPK, O'Reilly MA, Hynynen K, Aubert I, McLaurin J. Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease. Brain Research. PMID 29066368 DOI: 10.1016/J.Brainres.2017.10.015  0.599
2017 Hughes A, Hynynen K. Design of patient-specific focused ultrasound arrays for non-invasive brain therapy with increased trans-skull transmission and steering range. Physics in Medicine and Biology. PMID 28665289 DOI: 10.1088/1361-6560/Aa7Cd5  0.435
2017 Smirnov P, Hynynen K. Design of a HIFU array for the treatment of deep venous thrombosis: a simulation study. Physics in Medicine and Biology. PMID 28486218 DOI: 10.1088/1361-6560/Aa71Fb  0.324
2017 Tam F, Huang Y, Schwartz ML, Schweizer TA, Hynynen K, Graham SJ. A computerized tablet system for evaluating treatment of essential tremor by magnetic resonance guided focused ultrasound. Bmc Neurology. 17: 74. PMID 28412948 DOI: 10.1186/S12883-017-0856-8  0.304
2017 Meng Y, Volpini M, Black S, Lozano AM, Hynynen K, Lipsman N. Focused ultrasound as a novel strategy for Alzheimer's disease therapeutics. Annals of Neurology. PMID 28395123 DOI: 10.1002/Ana.24933  0.385
2017 McMahon D, Bendayan R, Hynynen K. Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome. Scientific Reports. 7: 45657. PMID 28374753 DOI: 10.1038/Srep45657  0.398
2017 O'Reilly MA, Hough O, Hynynen K. Blood-Brain Barrier Closure Time After Controlled Ultrasound-Induced Opening Is Independent of Opening Volume. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine. PMID 28108988 DOI: 10.7863/Ultra.16.02005  0.415
2017 Hughes A, Huang Y, Hynynen K. Towards transcranial focused ultrasound treatment planning: A technique for reduction of outer skull and skull base heating in transcranial focused ultrasound The Journal of the Acoustical Society of America. 141: 3489-3489. DOI: 10.1121/1.4987281  0.368
2017 Jones RM, O'Reilly MA, Deng L, Leung K, Hynynen K. Transcranial acoustic imaging for real-time control of ultrasound-mediated blood-brain barrier opening using a clinical-scale prototype system The Journal of the Acoustical Society of America. 141: 3489-3489. DOI: 10.1121/1.4987280  0.422
2017 Alli S, Figueredo C, Sabha N, Wu M, Bondoc A, Golbourn B, Luck A, Smith C, Wurdak H, Hynynen K, O’Reilly M, Rutka J. PDTM-33. FOCUSED ULTRASOUND DISRUPTION OF THE BLOOD BRAIN BARRIER IN THE BRAINSTEM: A FEASIBILITY AND SAFETY STUDY Neuro-Oncology. 19: vi197-vi197. DOI: 10.1093/Neuonc/Nox168.796  0.385
2017 Lipsman N, Ironside S, Alkins R, Bethune A, Huang Y, Perry J, Sahgal A, Trudeau M, Hynynen K, Mainprize T. Actr-42. Initial Experience Of Blood-Brain Barrier Opening For Chemotherapeutic-Drug Delivery To Brain Tumours By Mr-Guided Focused Ultrasound Neuro-Oncology. 19. DOI: 10.1093/Neuonc/Nox168.033  0.408
2017 Hynynen K, Jones RM, McMahon D, Deng L, Leung K, O'Reilly MA. Localized Image-Guided Drug Delivery into the Brain Using Novel Transmit/Receive Ultrasound Phased Arrays Ultrasound in Medicine & Biology. 43: S233. DOI: 10.1016/J.Ultrasmedbio.2017.08.1815  0.389
2016 Mooney SJ, Shah K, Yeung S, Burgess A, Aubert I, Hynynen K. Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability. Plos One. 11: e0159892. PMID 27459643 DOI: 10.1371/Journal.Pone.0159892  0.637
2016 Huang Y, Alkins R, Schwartz ML, Hynynen K. Opening the Blood-Brain Barrier with MR Imaging-guided Focused Ultrasound: Preclinical Testing on a Trans-Human Skull Porcine Model. Radiology. 152154. PMID 27420647 DOI: 10.1148/Radiol.2016152154  0.43
2016 Chu W, Staruch RM, Pichardo S, Tillander M, Köhler MO, Huang Y, Ylihautala M, McGuffin M, Czarnota G, Hynynen K. Magnetic Resonance-Guided High Intensity Focused Ultrasound Hyperthermia for Recurrent Rectal Cancer: MR Thermometry Evaluation and Preclinical Validation. International Journal of Radiation Oncology, Biology, Physics. PMID 27209510 DOI: 10.1016/J.Ijrobp.2016.03.019  0.32
2016 Lee J, Farha G, Poon I, Karam I, Higgins K, Pichardo S, Hynynen K, Enepekides D. Magnetic resonance-guided high-intensity focused ultrasound combined with radiotherapy for palliation of head and neck cancer-a pilot study. Journal of Therapeutic Ultrasound. 4: 12. PMID 27042308 DOI: 10.1186/S40349-016-0055-X  0.306
2016 Poon C, McMahon D, Hynynen K. Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound. Neuropharmacology. PMID 26907805 DOI: 10.1016/J.Neuropharm.2016.02.014  0.436
2016 Alkins R, Burgess A, Kerbel R, Wels WS, Hynynen K. Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival. Neuro-Oncology. PMID 26819443 DOI: 10.1017/Cjn.2015.76  0.375
2016 Burgess A, Hynynen K. Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System. Advances in Experimental Medicine and Biology. 880: 293-308. PMID 26486344 DOI: 10.1007/978-3-319-22536-4_16  0.436
2016 Zaaroor M, Sinai A, Goldsher D, Eran A, Nassar M, Schlesinger I, Parker J, Ravikumar V, Ghanouni P, Stein S, Halpern C, Krishna V, Hargrove A, Agrawal P, Changizi B, ... ... Hynynen K, ... ... Hynynen K, ... ... Hynynen K, ... ... Hynynen K, et al. 5th International Symposium on Focused Ultrasound Journal of Therapeutic Ultrasound. 4. DOI: 10.1186/S40349-016-0076-5  0.532
2016 Looi T, Khoklova V, Hynynen K, Drake J. A preliminary in-vivo porcine study of long pulse histotripsy for thrombolysis of intraventricular hemorrhagic clot The Journal of the Acoustical Society of America. 140: 3031-3032. DOI: 10.1121/1.4969405  0.338
2016 Hughes A, Hynynen K. Phased array techniques for multiple focus synthesis in transcranial focused ultrasound The Journal of the Acoustical Society of America. 139: 2117-2117. DOI: 10.1121/1.4950302  0.349
2016 O'Reilly MA, Jones RM, Hough O, Hynynen K. Acoustically controlled ultrasound-mediated drug delivery to the central nervous system The Journal of the Acoustical Society of America. 139: 2116-2116. DOI: 10.1121/1.4950297  0.392
2016 Hynynen K. WE-H-209-01: Advances in Ultrasound Therapy Medical Physics. 43: 3848-3848. DOI: 10.1118/1.4958020  0.359
2016 Goertz D, Hynynen K. Ultrasound-mediated drug delivery Physics Today. 69: 30-36. DOI: 10.1063/Pt.3.3106  0.342
2016 Poon C, Hynynen K. O1-04-02: Lifespan of one Focused Ultrasound Mediated Blood-Brain Barrier Treatment in a Mouse Model of Alzheimer's Disease Alzheimer's & Dementia. 12: P180-P180. DOI: 10.1016/J.Jalz.2016.06.311  0.37
2016 Liu M, Jevtic S, Markham-Coultes K, Hynynen K, Aubert I, McLaurin J. Investigating Multi-Therapeutic Amyloid Strategies For Treating Alzheimer’S Disease Alzheimers & Dementia. 12: 833. DOI: 10.1016/J.Jalz.2016.06.1701  0.553
2016 Weber-Adrian D, Noroozian Z, Silburt J, Shah K, Burgess A, Kügler S, Hynynen K, Aubert I. P2-247: Neuron-Specific Transgene Delivery to the Brain using MRI-Guided Focused Ultrasound Alzheimer's & Dementia. 12: P719-P720. DOI: 10.1016/J.Jalz.2016.06.1415  0.791
2016 Lynch M, O'Reilly M, Coultes K, Slyke PV, Dumont D, Hynynen K, Aubert I. Vasculotide Treatment Accelerates Blood-Brain Barrier Restoration After Focused Ultrasound In A Mouse Model Of Alzheimer'S Disease Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.1087  0.395
2016 Dubey S, Burgess A, McLaurin J, Branch DR, Hynynen K, Aubert I. Focused Ultrasound-Mediated Delivery Of Natural Antibodies To The Brain Facilitates Neuronal Plasticity In An Amyloidosis Mouse Model Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.1084  0.351
2015 Carias M, Hynynen K. Combined Therapeutic and Monitoring Ultrasonic Catheter for Cardiac Ablation Therapies. Ultrasound in Medicine & Biology. PMID 26431798 DOI: 10.1016/J.Ultrasmedbio.2015.08.015  0.332
2015 Burgess A, Shah K, Hough O, Hynynen K. Focused ultrasound-mediated drug delivery through the blood-brain barrier. Expert Review of Neurotherapeutics. 15: 477-91. PMID 25936845 DOI: 10.1586/14737175.2015.1028369  0.429
2015 O'Reilly MA, Hynynen K. Emerging non-cancer applications of therapeutic ultrasound. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 31: 310-8. PMID 25792225 DOI: 10.3109/02656736.2015.1004375  0.343
2015 Weber-Adrian D, Thévenot E, O'Reilly MA, Oakden W, Akens MK, Ellens N, Markham-Coultes K, Burgess A, Finkelstein J, Yee AJ, Whyne CM, Foust KD, Kaspar BK, Stanisz GJ, Chopra R, ... Hynynen K, et al. Gene delivery to the spinal cord using MRI-guided focused ultrasound. Gene Therapy. 22: 568-77. PMID 25781651 DOI: 10.1038/Gt.2015.25  0.765
2015 Staruch RM, Hynynen K, Chopra R. Hyperthermia-mediated doxorubicin release from thermosensitive liposomes using MR-HIFU: therapeutic effect in rabbit Vx2 tumours. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 31: 118-33. PMID 25582131 DOI: 10.3109/02656736.2014.992483  0.312
2015 Ellens NP, Kobelevskiy I, Chau A, Waspe AC, Staruch RM, Chopra R, Hynynen K. The targeting accuracy of a preclinical MRI-guided focused ultrasound system. Medical Physics. 42: 430-9. PMID 25563283 DOI: 10.1118/1.4903950  0.332
2015 Waspe A, Huang Y, Endre R, Amaral J, de Ruiter J, Campbell F, Mougenot C, Hynynen K, Czarnota G, Drake J, Temple M. Magnetic resonance guided focused ultrasound for noninvasive pain therapy of osteoid osteoma in children Journal of Therapeutic Ultrasound. 3. DOI: 10.1186/2050-5736-3-S1-O48  0.301
2015 O’Reilly M, Jones R, Hynynen K. Cavitation detection for brain imaging and therapy Journal of Therapeutic Ultrasound. 3. DOI: 10.1186/2050-5736-3-S1-O38  0.395
2015 Burgess A, Aubert I, Hynynen K. Delivery of stem cells to the brain: potential for treatment of neurodegenerative disease Journal of Therapeutic Ultrasound. 3: O17. DOI: 10.1186/2050-5736-3-S1-O17  0.602
2015 Burgess A, Dubey S, Nhan T, Aubert I, Hynynen K. Therapeutic effects of focused ultrasound-mediated blood-brain barrier opening in a mouse model of Alzheimer’s disease Journal of Therapeutic Ultrasound. 3. DOI: 10.1186/2050-5736-3-S1-O16  0.635
2015 Pulkkinen AT, Werner B, Martin E, Hynynen K. Numerical simulation of transcranial focused ultrasound therapy The Journal of the Acoustical Society of America. 138: 1907-1907. DOI: 10.1121/1.4933995  0.362
2015 Jones RM, Huang Y, Pajek D, Hynynen K. Computed tomography-based aberration correction for trans-skull acoustic focusing: Comparison of simulations and measurements with focused ultrasound brain systems The Journal of the Acoustical Society of America. 138: 1884-1884. DOI: 10.1121/1.4933910  0.378
2015 Hughes A, Hynynen K. An experimental study on the effect of temperature on the acoustic properties of cranial bone The Journal of the Acoustical Society of America. 138: 1799-1799. DOI: 10.1121/1.4933708  0.35
2015 Hynynen K. TU-CD-210-01: Advances in Focused Ultrasound Brain Therapies Medical Physics. 42: 3613-3613. DOI: 10.1118/1.4925638  0.402
2014 Nhan T, Burgess A, Lilge L, Hynynen K. Modeling localized delivery of Doxorubicin to the brain following focused ultrasound enhanced blood-brain barrier permeability. Physics in Medicine and Biology. 59: 5987-6004. PMID 25230100 DOI: 10.1088/0031-9155/59/20/5987  0.422
2014 Burgess A, Dubey S, Yeung S, Hough O, Eterman N, Aubert I, Hynynen K. Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. Radiology. 273: 736-45. PMID 25222068 DOI: 10.1148/Radiol.14140245  0.629
2014 Burgess A, Nhan T, Moffatt C, Klibanov AL, Hynynen K. Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy. Journal of Controlled Release : Official Journal of the Controlled Release Society. 192: 243-8. PMID 25107692 DOI: 10.1016/J.Jconrel.2014.07.051  0.419
2014 Pajek D, Burgess A, Huang Y, Hynynen K. High-intensity focused ultrasound sonothrombolysis: the use of perfluorocarbon droplets to achieve clot lysis at reduced acoustic power. Ultrasound in Medicine & Biology. 40: 2151-61. PMID 25023095 DOI: 10.1016/J.Ultrasmedbio.2014.03.026  0.36
2014 Ellens N, Hynynen K. Simulation study of the effects of near- and far-field heating during focused ultrasound uterine fibroid ablation using an electronically focused phased array: A theoretical analysis of patient safety. Medical Physics. 41: 072902. PMID 24989412 DOI: 10.1118/1.4883777  0.306
2014 Oakden W, Kwiecien JM, O'Reilly MA, Lake EM, Akens MK, Aubert I, Whyne C, Finkelstein J, Hynynen K, Stanisz GJ. A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles. Journal of Neuroscience Methods. 235: 92-100. PMID 24970578 DOI: 10.1016/J.Jneumeth.2014.06.018  0.54
2014 Lipsman N, Mainprize TG, Schwartz ML, Hynynen K, Lozano AM. Intracranial applications of magnetic resonance-guided focused ultrasound. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 593-605. PMID 24850310 DOI: 10.1007/S13311-014-0281-2  0.4
2014 O'Reilly MA, Jones RM, Hynynen K. Three-dimensional transcranial ultrasound imaging of microbubble clouds using a sparse hemispherical array. Ieee Transactions On Bio-Medical Engineering. 61: 1285-94. PMID 24658252 DOI: 10.1109/TBME.2014.2300838  0.303
2014 Burgess A, Hynynen K. Drug delivery across the blood-brain barrier using focused ultrasound. Expert Opinion On Drug Delivery. 11: 711-21. PMID 24650132 DOI: 10.1517/17425247.2014.897693  0.335
2014 Scarcelli T, Jordão JF, O'Reilly MA, Ellens N, Hynynen K, Aubert I. Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice. Brain Stimulation. 7: 304-7. PMID 24629831 DOI: 10.1016/J.Brs.2013.12.012  0.581
2014 Diaz RJ, McVeigh PZ, O'Reilly MA, Burrell K, Bebenek M, Smith C, Etame AB, Zadeh G, Hynynen K, Wilson BC, Rutka JT. Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors. Nanomedicine : Nanotechnology, Biology, and Medicine. 10: 1075-87. PMID 24374363 DOI: 10.1016/J.Nano.2013.12.006  0.346
2014 Lanza GM, Moonen C, Baker JR, Chang E, Cheng Z, Grodzinski P, Ferrara K, Hynynen K, Kelloff G, Lee YE, Patri AK, Sept D, Schnitzer JE, Wood BJ, Zhang M, et al. Assessing the barriers to image-guided drug delivery. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. 6: 1-14. PMID 24339356 DOI: 10.1002/Wnan.1247  0.339
2014 Carias M, Hynynen K. The evaluation of steerable ultrasonic catheters for minimally invasive MRI-guided cardiac ablation. Magnetic Resonance in Medicine. 72: 591-8. PMID 24114767 DOI: 10.1002/Mrm.24945  0.308
2014 O'Reilly MA, Jones RM, Burgess A, Tyson C, Hynynen K. Detection and control of cavitation during blood–brain barrier opening: Applications and clinical considerations The Journal of the Acoustical Society of America. 136: 2300-2300. DOI: 10.1121/1.4900320  0.384
2014 Alkins R, Huang Y, Hynynen K. Et-03Cavitation-Based Third Ventriculostomy Using Mri-Guided Focused Ultrasound Neuro-Oncology. 16. DOI: 10.1093/Neuonc/Nou255.3  0.427
2013 Nhan T, Burgess A, Hynynen K. Transducer design and characterization for dorsal-based ultrasound exposure and two-photon imaging of in vivo blood-brain barrier disruption in a rat model. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 60: 1376-85. PMID 25004505 DOI: 10.1109/Tuffc.2013.2710  0.404
2013 Pajek D, Hynynen K. The application of sparse arrays in high frequency transcranial focused ultrasound therapy: a simulation study. Medical Physics. 40: 122901. PMID 24320540 DOI: 10.1118/1.4829510  0.304
2013 Alkins R, Huang Y, Pajek D, Hynynen K. Cavitation-based third ventriculostomy using MRI-guided focused ultrasound. Journal of Neurosurgery. 119: 1520-9. PMID 24074494 DOI: 10.3171/2013.8.Jns13969  0.425
2013 Nhan T, Burgess A, Cho EE, Stefanovic B, Lilge L, Hynynen K. Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy. Journal of Controlled Release : Official Journal of the Controlled Release Society. 172: 274-80. PMID 24008151 DOI: 10.1016/J.Jconrel.2013.08.029  0.393
2013 Huang Y, Vykhodtseva NI, Hynynen K. Creating brain lesions with low-intensity focused ultrasound with microbubbles: a rat study at half a megahertz. Ultrasound in Medicine & Biology. 39: 1420-8. PMID 23743099 DOI: 10.1016/J.Ultrasmedbio.2013.03.006  0.369
2013 Jordão JF, Thévenot E, Markham-Coultes K, Scarcelli T, Weng YQ, Xhima K, O'Reilly M, Huang Y, McLaurin J, Hynynen K, Aubert I. Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound. Experimental Neurology. 248: 16-29. PMID 23707300 DOI: 10.1016/J.Expneurol.2013.05.008  0.629
2013 Alkins RD, Brodersen PM, Sodhi RN, Hynynen K. Enhancing drug delivery for boron neutron capture therapy of brain tumors with focused ultrasound. Neuro-Oncology. 15: 1225-35. PMID 23640533 DOI: 10.1093/Neuonc/Not052  0.367
2013 Lipsman N, Schwartz ML, Huang Y, Lee L, Sankar T, Chapman M, Hynynen K, Lozano AM. MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study. The Lancet. Neurology. 12: 462-8. PMID 23523144 DOI: 10.1016/S1474-4422(13)70048-6  0.319
2013 Burgess A, Hynynen K. Noninvasive and targeted drug delivery to the brain using focused ultrasound. Acs Chemical Neuroscience. 4: 519-26. PMID 23379618 DOI: 10.1021/Cn300191B  0.429
2013 Alkins R, Burgess A, Ganguly M, Francia G, Kerbel R, Wels WS, Hynynen K. Focused ultrasound delivers targeted immune cells to metastatic brain tumors. Cancer Research. 73: 1892-9. PMID 23302230 DOI: 10.1158/0008-5472.Can-12-2609  0.355
2013 Lucht B, Hubbell A, Hynynen K. Contrast-enhanced transcranial two-dimensional ultrasound imaging using shear-mode conversion at low frequency. Ultrasound in Medicine & Biology. 39: 332-44. PMID 23245822 DOI: 10.1016/J.Ultrasmedbio.2012.09.007  0.327
2013 Todorova M, Agache V, Mortazavi O, Chen B, Karshafian R, Hynynen K, Man S, Kerbel RS, Goertz DE. Antitumor effects of combining metronomic chemotherapy with the antivascular action of ultrasound stimulated microbubbles. International Journal of Cancer. Journal International Du Cancer. 132: 2956-66. PMID 23225339 DOI: 10.1002/Ijc.27977  0.341
2013 Hynynen K, Burgess A, O’Reilly MM, Alkins R, Pajek D, Ellens N, Hughes A. Advances in ultrasound methods for therapy The Journal of the Acoustical Society of America. 134: 4088-4088. DOI: 10.1121/1.4830932  0.411
2013 Burgess A, Huang Y, Querbes W, Sah DW, Hynynen K. Non-invasive delivery of small interfering rubonucleic acid for reduction of Huntingtin expression in the brain is achieved using focused ultrasound to disrupt the blood-brain barrier Proceedings of Meetings On Acoustics. 19. DOI: 10.1121/1.4805947  0.419
2013 Burgess A, Eterman N, Aubert I, Hynynen K. Two-photon microscopy for real-time monitoring of focused ultrasoundmediated drug delivery to the brain in a mouse model of Alzheimer's disease Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8588. DOI: 10.1117/12.2002124  0.63
2012 Goertz DE, Todorova M, Mortazavi O, Agache V, Chen B, Karshafian R, Hynynen K. Antitumor effects of combining docetaxel (taxotere) with the antivascular action of ultrasound stimulated microbubbles. Plos One. 7: e52307. PMID 23284980 DOI: 10.1371/Journal.Pone.0052307  0.307
2012 Staruch RM, Ganguly M, Tannock IF, Hynynen K, Chopra R. Enhanced drug delivery in rabbit VX2 tumours using thermosensitive liposomes and MRI-controlled focused ultrasound hyperthermia. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 28: 776-87. PMID 23153219 DOI: 10.3109/02656736.2012.736670  0.337
2012 Burgess A, Huang Y, Querbes W, Sah DW, Hynynen K. Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression. Journal of Controlled Release : Official Journal of the Controlled Release Society. 163: 125-9. PMID 22921802 DOI: 10.1016/J.Jconrel.2012.08.012  0.417
2012 Burgess A, Huang Y, Waspe AC, Ganguly M, Goertz DE, Hynynen K. High-intensity focused ultrasound (HIFU) for dissolution of clots in a rabbit model of embolic stroke. Plos One. 7: e42311. PMID 22870315 DOI: 10.1371/Journal.Pone.0042311  0.331
2012 Thévenot E, Jordão JF, O'Reilly MA, Markham K, Weng YQ, Foust KD, Kaspar BK, Hynynen K, Aubert I. Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound. Human Gene Therapy. 23: 1144-55. PMID 22838844 DOI: 10.1089/Hum.2012.013  0.655
2012 Treat LH, McDannold N, Zhang Y, Vykhodtseva N, Hynynen K. Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound in Medicine & Biology. 38: 1716-25. PMID 22818878 DOI: 10.1016/J.Ultrasmedbio.2012.04.015  0.417
2012 Pajek D, Hynynen K. The design of a focused ultrasound transducer array for the treatment of stroke: a simulation study. Physics in Medicine and Biology. 57: 4951-68. PMID 22800986 DOI: 10.1088/0031-9155/57/15/4951  0.336
2012 O'Reilly MA, Hynynen K. Ultrasound enhanced drug delivery to the brain and central nervous system. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 28: 386-96. PMID 22621739 DOI: 10.3109/02656736.2012.666709  0.315
2012 Miller DL, Smith NB, Bailey MR, Czarnota GJ, Hynynen K, Makin IR. Overview of therapeutic ultrasound applications and safety considerations. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine. 31: 623-34. PMID 22441920 DOI: 10.7863/Jum.2012.31.4.623  0.338
2012 Staruch R, Chopra R, Hynynen K. Hyperthermia in bone generated with MR imaging-controlled focused ultrasound: control strategies and drug delivery. Radiology. 263: 117-27. PMID 22438444 DOI: 10.1148/Radiol.12111189  0.331
2012 O'Reilly MA, Waspe AC, Chopra R, Hynynen K. MRI-guided disruption of the blood-brain barrier using transcranial focused ultrasound in a rat model. Journal of Visualized Experiments : Jove. PMID 22433937 DOI: 10.3791/3555  0.435
2012 Wright C, Hynynen K, Goertz D. In vitro and in vivo high-intensity focused ultrasound thrombolysis. Investigative Radiology. 47: 217-25. PMID 22373533 DOI: 10.1097/Rli.0B013E31823Cc75C  0.312
2012 Etame AB, Diaz RJ, O'Reilly MA, Smith CA, Mainprize TG, Hynynen K, Rutka JT. Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound. Nanomedicine : Nanotechnology, Biology, and Medicine. 8: 1133-42. PMID 22349099 DOI: 10.1016/J.Nano.2012.02.003  0.416
2012 Etame AB, Diaz RJ, Smith CA, Mainprize TG, Hynynen K, Rutka JT. Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology. Neurosurgical Focus. 32: E3. PMID 22208896 DOI: 10.3171/2011.10.Focus11252  0.407
2012 Wright CC, Hynynen K, Goertz DE. Pulsed focused ultrasound-induced displacements in confined in vitro blood clots. Ieee Transactions On Bio-Medical Engineering. 59: 842-51. PMID 22194235 DOI: 10.1109/Tbme.2011.2180904  0.332
2012 Hynynen K, Huang Y, O'Reilly M, Jones R, Pajek D, Pulkkinen A. Ultrasound therapy delivery and monitoring through intact skull The Journal of the Acoustical Society of America. 132: 1927-1927. DOI: 10.1121/1.4755075  0.405
2012 Burgess A, Cho EE, Shaffaf L, Nhan T, Poon C, Hynynen K. The use of two-photon microscopy to study the biological effects of focused ultrasound on the brain Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8226. DOI: 10.1117/12.908826  0.431
2011 Staruch R, Chopra R, Hynynen K. MRI-controlled ultrasound thermal therapy. Ieee Pulse. 2: 39-47. PMID 25372968 DOI: 10.1109/Mpul.2011.942604  0.384
2011 Hynynen K. MRIgHIFU: a tool for image-guided therapeutics. Journal of Magnetic Resonance Imaging : Jmri. 34: 482-93. PMID 22896850 DOI: 10.1002/Jmri.22649  0.387
2011 Burgess A, Aubert I, Hynynen K. Focused ultrasound: crossing barriers to treat Alzheimer's disease. Therapeutic Delivery. 2: 281-6. PMID 22833998 DOI: 10.4155/Tde.11.5  0.563
2011 El-Desouki MM, Hynynen K. Driving circuitry for focused ultrasound noninvasive surgery and drug delivery applications. Sensors (Basel, Switzerland). 11: 539-56. PMID 22346589 DOI: 10.3390/S110100539  0.334
2011 Burgess A, Ayala-Grosso CA, Ganguly M, Jordão JF, Aubert I, Hynynen K. Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier. Plos One. 6: e27877. PMID 22114718 DOI: 10.1371/Journal.Pone.0027877  0.612
2011 O'Reilly MA, Muller A, Hynynen K. Ultrasound insertion loss of rat parietal bone appears to be proportional to animal mass at submegahertz frequencies. Ultrasound in Medicine & Biology. 37: 1930-7. PMID 21925788 DOI: 10.1016/J.Ultrasmedbio.2011.08.001  0.312
2011 Curiel L, Hynynen K. Localized harmonic motion imaging for focused ultrasound surgery targeting. Ultrasound in Medicine & Biology. 37: 1230-9. PMID 21683514 DOI: 10.1016/J.Ultrasmedbio.2011.05.013  0.338
2011 Cho EE, Drazic J, Ganguly M, Stefanovic B, Hynynen K. Two-photon fluorescence microscopy study of cerebrovascular dynamics in ultrasound-induced blood-brain barrier opening. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 1852-62. PMID 21505473 DOI: 10.1038/Jcbfm.2011.59  0.361
2011 Tempany CM, McDannold NJ, Hynynen K, Jolesz FA. Focused ultrasound surgery in oncology: overview and principles. Radiology. 259: 39-56. PMID 21436096 DOI: 10.1148/Radiol.11100155  0.332
2011 O'Reilly MA, Waspe AC, Ganguly M, Hynynen K. Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate. Ultrasound in Medicine & Biology. 37: 587-94. PMID 21376455 DOI: 10.1016/J.Ultrasmedbio.2011.01.008  0.332
2011 Huang Y, Hynynen K. MR-guided focused ultrasound for brain ablation and blood-brain barrier disruption. Methods in Molecular Biology (Clifton, N.J.). 711: 579-93. PMID 21279624 DOI: 10.1007/978-1-61737-992-5_30  0.441
2011 Staruch R, Chopra R, Hynynen K. Localised drug release using MRI-controlled focused ultrasound hyperthermia. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 27: 156-71. PMID 21158487 DOI: 10.3109/02656736.2010.518198  0.334
2011 Hynynen K. WE-A-220-02: Focused Ultrasound Treatment of Brain-Review Medical Physics. 38: 3798-3798. DOI: 10.1118/1.3613297  0.385
2011 Burgess A, Ayala-Grosso CA, Ganguly M, Jordão J, Aubert I, Hynynen K. Delivery of stem cells to the brain using MRIgFUS Ieee International Ultrasonics Symposium, Ius. 13-16. DOI: 10.1109/ULTSYM.2011.0004  0.539
2010 Jalali S, Huang Y, Dumont DJ, Hynynen K. Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats. Bmc Neurology. 10: 114. PMID 21078165 DOI: 10.1186/1471-2377-10-114  0.402
2010 Schad KC, Hynynen K. In vitro characterization of perfluorocarbon droplets for focused ultrasound therapy. Physics in Medicine and Biology. 55: 4933-47. PMID 20693614 DOI: 10.1088/0031-9155/55/17/004  0.312
2010 Chopra R, Vykhodtseva N, Hynynen K. Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures. Acs Chemical Neuroscience. 1: 391-398. PMID 20563295 DOI: 10.1021/Cn9000445  0.401
2010 O'Reilly MA, Hynynen K. A PVDF receiver for ultrasound monitoring of transcranial focused ultrasound therapy. Ieee Transactions On Bio-Medical Engineering. 57: 2286-94. PMID 20515709 DOI: 10.1109/Tbme.2010.2050483  0.346
2010 Jordão JF, Ayala-Grosso CA, Markham K, Huang Y, Chopra R, McLaurin J, Hynynen K, Aubert I. Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease. Plos One. 5: e10549. PMID 20485502 DOI: 10.1371/Journal.Pone.0010549  0.61
2010 Goertz DE, Wright C, Hynynen K. Contrast agent kinetics in the rabbit brain during exposure to therapeutic ultrasound. Ultrasound in Medicine & Biology. 36: 916-24. PMID 20447757 DOI: 10.1016/J.Ultrasmedbio.2010.03.005  0.387
2010 Klotz AR, Lindvere L, Stefanovic B, Hynynen K. Temperature change near microbubbles within a capillary network during focused ultrasound. Physics in Medicine and Biology. 55: 1549-61. PMID 20164536 DOI: 10.1088/0031-9155/55/6/001  0.341
2010 Hynynen K, Roemer R, Anhalt D, Johnson C, Xu ZX, Swindell W, Cetas T. A scanned, focused, multiple transducer ultrasonic system for localized hyperthermia treatments. 1987. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 26: 1-11. PMID 20100046 DOI: 10.3109/02656730903492916  0.346
2010 McDannold N, Clement GT, Black P, Jolesz F, Hynynen K. Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery. 66: 323-32; discussion 3. PMID 20087132 DOI: 10.1227/01.Neu.0000360379.95800.2F  0.351
2010 Hynynen K. MRI-guided focused ultrasound treatments. Ultrasonics. 50: 221-9. PMID 19818981 DOI: 10.1016/J.Ultras.2009.08.015  0.379
2010 Song J, Hynynen K. Feasibility of using lateral mode coupling method for a large scale ultrasound phased array for noninvasive transcranial therapy. Ieee Transactions On Bio-Medical Engineering. 57: 124-33. PMID 19695987 DOI: 10.1109/Tbme.2009.2028739  0.338
2010 O’Reilly MA, Hynynen K. Optimizing parameters for ultrasound‐induced disruption of the blood‐brain barrier. Journal of the Acoustical Society of America. 128: 2415-2415. DOI: 10.1121/1.3508619  0.356
2010 Schad K, Hynynen K. Cavitation and vaporization threshold of perfluorocarbon droplets. The Journal of the Acoustical Society of America. 127: 1975-1975. DOI: 10.1121/1.3385061  0.303
2009 Colucci V, Strichartz G, Jolesz F, Vykhodtseva N, Hynynen K. Focused ultrasound effects on nerve action potential in vitro. Ultrasound in Medicine & Biology. 35: 1737-47. PMID 19647923 DOI: 10.1016/J.Ultrasmedbio.2009.05.002  0.302
2009 Huang Y, Curiel L, Kukic A, Plewes DB, Chopra R, Hynynen K. MR acoustic radiation force imaging: in vivo comparison to ultrasound motion tracking. Medical Physics. 36: 2016-20. PMID 19610290 DOI: 10.1118/1.3120289  0.34
2009 Chopra R, Curiel L, Staruch R, Morrison L, Hynynen K. An MRI-compatible system for focused ultrasound experiments in small animal models. Medical Physics. 36: 1867-74. PMID 19544806 DOI: 10.1118/1.3115680  0.435
2009 Pilatou MC, Stewart EA, Maier SE, Fennessy FM, Hynynen K, Tempany CM, McDannold N. MRI-based thermal dosimetry and diffusion-weighted imaging of MRI-guided focused ultrasound thermal ablation of uterine fibroids. Journal of Magnetic Resonance Imaging : Jmri. 29: 404-11. PMID 19161196 DOI: 10.1002/Jmri.21688  0.305
2009 Yousefi A, Goertz DE, Hynynen K. Transcranial shear-mode ultrasound: assessment of imaging performance and excitation techniques. Ieee Transactions On Medical Imaging. 28: 763-74. PMID 19150789 DOI: 10.1109/Tmi.2008.2012017  0.302
2009 Hynynen K. Macromolecular delivery across the blood-brain barrier. Methods in Molecular Biology (Clifton, N.J.). 480: 175-85. PMID 19085123 DOI: 10.1007/978-1-59745-429-2_13  0.417
2009 Curiel L, Chopra R, Hynynen K. In Vivo Monitoring of Focused Ultrasound Surgery Using Local Harmonic Motion Ultrasound in Medicine and Biology. 35: 65-78. PMID 18805626 DOI: 10.1016/J.Ultrasmedbio.2008.07.001  0.308
2009 Daum DR, Hynynen K. Thermal dose optimization via temporal switching in ultrasound surgery. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 45: 208-15. PMID 18244173 DOI: 10.1109/58.646926  0.342
2009 Hynynen K, Sun J. Trans-skull ultrasound therapy: the feasibility of using image-derived skull thickness information to correct the phase distortion. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 46: 752-5. PMID 18238476 DOI: 10.1109/58.764862  0.324
2009 Aubert I, Weng Y, DaSilva KA, Jordao J, Ayala-Grosso CA, Coultes K, Brown ME, Hynynen K, Seki T, McLaurin J. Anti-amyloid beta treatments: can they promote cholinergic survival and neurogenesis? Neuroscience Research. 65: S64. DOI: 10.1016/J.Neures.2009.09.193  0.521
2008 McDannold N, Tempany C, Jolesz F, Hynynen K. Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids Journal of Magnetic Resonance Imaging. 28: 1026-1032. PMID 18821603 DOI: 10.1002/Jmri.21506  0.325
2008 Lánä́rd ZM, McDannold NJ, Fennessy FM, Stewart EA, Jolesz FA, Hynynen K, Tempany CMC. Uterine leiomyomas: MR imaging-guided focused ultrasound surgery-imaging predictors of success 1 Radiology. 249: 187-194. PMID 18695211 DOI: 10.1148/Radiol.2491071600  0.317
2008 Vykhodtseva N, McDannold N, Hynynen K. Progress and problems in the application of focused ultrasound for blood-brain barrier disruption Ultrasonics. 48: 279-296. PMID 18511095 DOI: 10.1016/J.Ultras.2008.04.004  0.41
2008 Hynynen K. Ultrasound for drug and gene delivery to the brain Advanced Drug Delivery Reviews. 60: 1209-1217. PMID 18486271 DOI: 10.1016/J.Addr.2008.03.010  0.445
2008 Raymond SB, Treat LH, Dewey JD, McDannold NJ, Hynynen K, Bacskai BJ. Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. Plos One. 3: e2175. PMID 18478109 DOI: 10.1371/Journal.Pone.0002175  0.43
2008 Sheikov N, McDannold N, Sharma S, Hynynen K. Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium Ultrasound in Medicine and Biology. 34: 1093-1104. PMID 18378064 DOI: 10.1016/J.Ultrasmedbio.2007.12.015  0.405
2008 McDannold N, Vykhodtseva N, Hynynen K. Effects of Acoustic Parameters and Ultrasound Contrast Agent Dose on Focused-Ultrasound Induced Blood-Brain Barrier Disruption Ultrasound in Medicine and Biology. 34: 930-937. PMID 18294757 DOI: 10.1016/J.Ultrasmedbio.2007.11.009  0.427
2008 McDannold N, Vykhodtseva N, Hynynen K. Blood-Brain Barrier Disruption Induced by Focused Ultrasound and Circulating Preformed Microbubbles Appears to Be Characterized by the Mechanical Index Ultrasound in Medicine and Biology. 34: 834-840. PMID 18207311 DOI: 10.1016/J.Ultrasmedbio.2007.10.016  0.382
2008 Hynynen K, Curiel L, Chopra R. In vivo feasibility of local harmonic motion imaging and its use for thermal surgery control The Journal of the Acoustical Society of America. 123: 3792-3792. DOI: 10.1121/1.2935459  0.321
2008 Hynynen K, Curiel L, Chopra R. The feasibility of local harmonic motion imaging for the guidance and control of focused ultrasound surgery The Journal of the Acoustical Society of America. 123: 2994-2994. DOI: 10.1121/1.2932542  0.327
2007 Curiel L, Chopra R, Hynynen K. Progress in multimodality imaging: Truly simultaneous ultrasound and magnetic resonance imaging Ieee Transactions On Medical Imaging. 26: 1740-1747. PMID 18092742 DOI: 10.1109/Tmi.2007.903572  0.327
2007 Pichardo S, Hynynen K. Treatment of near-skull brain tissue with a focused device using shear-mode conversion: A numerical study Physics in Medicine and Biology. 52: 7313-7332. PMID 18065841 DOI: 10.1088/0031-9155/52/24/008  0.331
2007 Tang SC, Clement GT, Hynynen K. A computer-controlled ultrasound pulser-receiver system for transskull fluid detection using a shear wave transmission technique Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 54: 1772-1783. PMID 17941383 DOI: 10.1109/Tuffc.2007.461  0.302
2007 Pichardo S, Hynynen K. Circumferential lesion formation around the pulmonary veins in the left atrium with focused ultrasound using a 2D-array endoesophageal device: A numerical study Physics in Medicine and Biology. 52: 4923-4942. PMID 17671344 DOI: 10.1088/0031-9155/52/16/014  0.302
2007 Sassaroli E, Hynynen K. Cavitation Threshold of Microbubbles in Gel Tunnels by Focused Ultrasound Ultrasound in Medicine and Biology. 33: 1651-1660. PMID 17590501 DOI: 10.1016/J.Ultrasmedbio.2007.04.018  0.329
2007 Hynynen K, Clement G. Clinical applications of focused ultrasound-the brain. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 23: 193-202. PMID 17578343 DOI: 10.1080/02656730701200094  0.378
2007 Muldoon LL, Soussain C, Jahnke K, Johanson C, Siegal T, Smith QR, Hall WA, Hynynen K, Senter PD, Peereboom DM, Neuwelt EA. Chemotherapy delivery issues in central nervous system malignancy: a reality check. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 25: 2295-305. PMID 17538176 DOI: 10.1200/Jco.2006.09.9861  0.351
2007 Treat LH, McDannold N, Vykhodtseva N, Zhang Y, Tam K, Hynynen K. Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound International Journal of Cancer. 121: 901-907. PMID 17437269 DOI: 10.1002/Ijc.22732  0.439
2007 McDannold N, Vykhodtseva N, Hynynen K. Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study. Ultrasound in Medicine & Biology. 33: 584-90. PMID 17337109 DOI: 10.1016/J.Ultrasmedbio.2006.10.004  0.416
2007 Raymond SB, Skoch J, Bacskai BJ, Hynynen K. Modular design for in vivo optical imaging and ultrasound treatment in the murine brain. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 54: 431-4. PMID 17328340 DOI: 10.1109/Tuffc.2007.257  0.39
2007 Hynynen K. Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain. Expert Opinion On Drug Delivery. 4: 27-35. PMID 17184160 DOI: 10.1517/17425247.4.1.27  0.446
2007 Vykhodtseva N, McDannold N, Hynynen K. Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison. Ultrasound in Medicine & Biology. 32: 1923-9. PMID 17169704 DOI: 10.1016/J.Ultrasmedbio.2006.06.026  0.347
2007 McDannold N, Hynynen K. Quality assurance and system stability of a clinical MRI-guided focused ultrasound system: four-year experience. Medical Physics. 33: 4307-13. PMID 17153409 DOI: 10.1118/1.2352853  0.327
2007 Heikkilä J, Hynynen K. Investigation of optimal method for inducing harmonic motion in tissue using a linear ultrasound phased array--a simulation study. Ultrasonic Imaging. 28: 97-113. PMID 17094690 DOI: 10.1177/016173460602800203  0.32
2007 Raymond SB, Skoch J, Hynynen K, Bacskai BJ. Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 393-403. PMID 16685254 DOI: 10.1038/Sj.Jcbfm.9600336  0.405
2007 Sokka S, Hynynen K. Cavitation-enhanced ultrasound heating in vivo: Mechanisms and implications in MR-guided high-intensity focused ultrasound therapy The Journal of the Acoustical Society of America. 122: 3078. DOI: 10.1121/1.2942993  0.35
2006 Dimaio SP, Archip N, Hata N, Talos IF, Warfield SK, Majumdar A, Mcdannold N, Hynynen K, Morrison PR, Wells WM, Kacher DF, Ellis RE, Golby AJ, Black PM, Jolesz FA, et al. Image-guided neurosurgery at Brigham and Women's Hospital. Ieee Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society. 25: 67-73. PMID 17020201 DOI: 10.1109/Memb.2006.1705749  0.31
2006 McDannold NJ, Vykhodtseva NI, Hynynen K. Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits Radiology. 241: 95-106. PMID 16990673 DOI: 10.1148/Radiol.2411051170  0.376
2006 Sheikov N, McDannold N, Jolesz F, Zhang YZ, Tam K, Hynynen K. Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier. Ultrasound in Medicine & Biology. 32: 1399-409. PMID 16965980 DOI: 10.1016/J.Ultrasmedbio.2006.05.015  0.393
2006 Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA, Sheikov N. Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. Journal of Neurosurgery. 105: 445-54. PMID 16961141 DOI: 10.3171/Jns.2006.105.3.445  0.431
2006 Kinoshita M, McDannold N, Jolesz FA, Hynynen K. Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proceedings of the National Academy of Sciences of the United States of America. 103: 11719-23. PMID 16868082 DOI: 10.1073/Pnas.0604318103  0.423
2006 McDannold N, Tempany CM, Fennessy FM, So MJ, Rybicki FJ, Stewart EA, Jolesz FA, Hynynen K. Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation. Radiology. 240: 263-72. PMID 16793983 DOI: 10.1148/Radiol.2401050717  0.321
2006 Hynynen K, McDannold N, Clement G, Jolesz FA, Zadicario E, Killiany R, Moore T, Rosen D. Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain-A primate study European Journal of Radiology. 59: 149-156. PMID 16716552 DOI: 10.1016/J.Ejrad.2006.04.007  0.382
2006 White PJ, Clement GT, Hynynen K. Local frequency dependence in transcranial ultrasound transmission Physics in Medicine and Biology. 51: 2293-2305. PMID 16625043 DOI: 10.1088/0031-9155/51/9/013  0.349
2006 Kinoshita M, Hynynen K. Mechanism of porphyrin-induced sonodynamic effect: possible role of hyperthermia. Radiation Research. 165: 299-306. PMID 16494518 DOI: 10.1667/Rr3510.1  0.325
2006 McDannold N, Vykhodtseva N, Hynynen K. Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity. Physics in Medicine and Biology. 51: 793-807. PMID 16467579 DOI: 10.1088/0031-9155/51/4/003  0.357
2006 McDannold N, Vykhodtseva N, Raymond S, Jolesz FA, Hynynen K. MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. Ultrasound in Medicine & Biology. 31: 1527-37. PMID 16286030 DOI: 10.1016/J.Ultrasmedbio.2005.07.010  0.443
2006 Sassaroli E, Hynynen K. On the impact of vessel size on the threshold of bubble collapse The Journal of the Acoustical Society of America. 119: 3408-3408. DOI: 10.1121/1.4786778  0.321
2006 Sokka SD, Vykhodtseva N, Hynynen K. Cavitation‐enhanced ultrasound heating in vivo: Therapy protocols, mechanisms, and acoustic and MRI monitoring The Journal of the Acoustical Society of America. 119: 3227-3227. DOI: 10.1121/1.4785950  0.344
2006 Vykhodtseva N, McDannold N, Hynynen K. Effects of short‐pulsed focused ultrasound: Histological study on the rabbit brain in vivo The Journal of the Acoustical Society of America. 119: 3213-3213. DOI: 10.1121/1.4785887  0.337
2006 Hynynen K. MO-E-ValB-03: MRI-Guided Focused Ultrasound Medical Physics. 33: 2172-2173. DOI: 10.1118/1.2241461  0.397
2005 Clement GT, Huttunen J, Hynynen K. Superresolution ultrasound imaging using back-projected reconstruction Journal of the Acoustical Society of America. 118: 3953-3960. PMID 16419839 DOI: 10.1121/1.2109167  0.31
2005 Kinoshita M, McDannold N, Jolesz FA, Hynynen K. Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. Biochemical and Biophysical Research Communications. 340: 1085-90. PMID 16403441 DOI: 10.1016/J.Bbrc.2005.12.112  0.416
2005 White J, Clement GT, Hynynen K. Transcranial ultrasound focus reconstruction with phase and amplitude correction. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 52: 1518-22. PMID 16285450 DOI: 10.1109/Tuffc.2005.1516024  0.351
2005 Sassaroli E, Hynynen K. Resonance frequency of microbubbles in small blood vessels: a numerical study. Physics in Medicine and Biology. 50: 5293-305. PMID 16264254 DOI: 10.1088/0031-9155/50/22/006  0.32
2005 Jolesz FA, Hynynen K, McDannold N, Tempany C. MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery. Magnetic Resonance Imaging Clinics of North America. 13: 545-60. PMID 16084419 DOI: 10.1016/J.Mric.2005.04.008  0.399
2005 Kinoshita M, Hynynen K. A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound. Biochemical and Biophysical Research Communications. 335: 393-9. PMID 16081042 DOI: 10.1016/J.Bbrc.2005.07.101  0.355
2005 Clement GT, White PJ, King RL, McDannold N, Hynynen K. A magnetic resonance imaging-compatible, large-scale array for trans-skull ultrasound surgery and therapy. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine. 24: 1117-25. PMID 16040827 DOI: 10.7863/Jum.2005.24.8.1117  0.382
2005 Malinen M, Huttunen T, Kaipio JP, Hynynen K. Scanning path optimization for ultrasound surgery. Physics in Medicine and Biology. 50: 3473-90. PMID 16030378 DOI: 10.1088/0031-9155/50/15/001  0.309
2005 Liu HL, McDannold N, Hynynen K. Focal beam distortion and treatment planning in abdominal focused ultrasound surgery. Medical Physics. 32: 1270-80. PMID 15984679 DOI: 10.1118/1.1895525  0.337
2005 Silcox CE, Smith RC, King R, McDannold N, Bromley P, Walsh K, Hynynen K. MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate. Ultrasound in Medicine & Biology. 31: 965-70. PMID 15972202 DOI: 10.1016/J.Ultrasmedbio.2005.03.009  0.336
2005 Aarnio J, Clement GT, Hynynen K. A new ultrasound method for determining the acoustic phase shifts caused by the skull bone Ultrasound in Medicine and Biology. 31: 771-780. PMID 15936493 DOI: 10.1016/J.Ultrasmedbio.2005.01.019  0.314
2005 Yin X, Hynynen K. A numerical study of transcranial focused ultrasound beam propagation at low frequency. Physics in Medicine and Biology. 50: 1821-36. PMID 15815098 DOI: 10.1088/0031-9155/50/8/013  0.352
2005 Clement GT, Hynynen K. Ultrasound phase-contrast transmission imaging of localized thermal variation and the identification of fat/tissue boundaries Physics in Medicine and Biology. 50: 1585-1600. PMID 15798345 DOI: 10.1088/0031-9155/50/7/018  0.352
2005 Hynynen K, McDannold N. MRI guided and monitored focused ultrasound thermal ablation methods: a review of progress. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 20: 725-37. PMID 15675668 DOI: 10.1080/02656730410001716597  0.353
2005 Hynynen K, McDannold N, Sheikov NA, Jolesz FA, Vykhodtseva N. Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. Neuroimage. 24: 12-20. PMID 15588592 DOI: 10.1016/J.Neuroimage.2004.06.046  0.427
2005 White PJ, Clement GT, Hynynen K. Frequency‐dependent ultrasound transmission through the human skull The Journal of the Acoustical Society of America. 117: 2412-2412. DOI: 10.1121/1.4786266  0.351
2005 Hynynen K, McDannold N, Clement G, White J, Treat L, Yin X, Jolesz F, Sheikov N, Vykhodtseva N. Feasibility of noninvasive ultrasound delivery for tumor ablation and targeted drug delivery in the brain The Journal of the Acoustical Society of America. 117: 2411-2411. DOI: 10.1121/1.4786256  0.433
2005 McDannold N, Hynynen K. MRI guidance for focused ultrasound surgery The Journal of the Acoustical Society of America. 118: 1882-1882. DOI: 10.1121/1.4779487  0.379
2005 Clement GT, White PJ, Hynynen K. Feasibility of shear‐mode transcranial ultrasound imaging The Journal of the Acoustical Society of America. 117: 2588-2588. DOI: 10.1121/1.4777218  0.306
2004 Jolesz FA, Hynynen K, McDannold N, Freundlich D, Kopelman D. Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound. Gastroenterology. 127: S242-7. PMID 15508090 DOI: 10.1053/J.Gastro.2004.09.056  0.347
2004 Connor CW, Hynynen K. Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery. Ieee Transactions On Bio-Medical Engineering. 51: 1693-706. PMID 15490817 DOI: 10.1109/Tbme.2004.831516  0.432
2004 Sheikov N, McDannold N, Vykhodtseva N, Jolesz F, Hynynen K. Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound in Medicine & Biology. 30: 979-89. PMID 15313330 DOI: 10.1016/J.Ultrasmedbio.2004.04.010  0.391
2004 Hynynen K, Clement GT, McDannold N, Vykhodtseva N, King R, White PJ, Vitek S, Jolesz FA. 500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls. Magnetic Resonance in Medicine. 52: 100-7. PMID 15236372 DOI: 10.1002/Mrm.20118  0.407
2004 McDannold N, King RL, Hynynen K. MRI monitoring of heating produced by ultrasound absorption in the skull: in vivo study in pigs. Magnetic Resonance in Medicine. 51: 1061-5. PMID 15122691 DOI: 10.1002/Mrm.20043  0.353
2004 McDannold N, Vykhodtseva N, Jolesz FA, Hynynen K. MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain. Magnetic Resonance in Medicine. 51: 913-23. PMID 15122673 DOI: 10.1002/Mrm.20060  0.399
2004 Clement GT, White PJ, Hynynen K. Enhanced ultrasound transmission through the human skull using shear mode conversion Journal of the Acoustical Society of America. 115: 1356-1364. PMID 15058357 DOI: 10.1121/1.1645610  0.302
2004 Konofagou EE, Ottensmeyer M, Agabian S, Dawson SL, Hynynen K. Estimating localized oscillatory tissue motion for assessment of the underlying mechanical modulus. Ultrasonics. 42: 951-6. PMID 15047412 DOI: 10.1016/J.Ultras.2003.12.001  0.31
2004 McDannold N, Fossheim SL, Rasmussen H, Martin H, Vykhodtseva N, Hynynen K. Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit liver and kidney. Radiology. 230: 743-52. PMID 14764890 DOI: 10.1148/Radiol.2303021713  0.304
2004 Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA. Non-invasive opening of BBB by focused ultrasound. Acta Neurochirurgica. Supplement. 86: 555-8. PMID 14753505 DOI: 10.1007/978-3-7091-0651-8_113  0.438
2004 Giesecke T, Hynynen K. Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro. Ultrasound in Medicine & Biology. 29: 1359-65. PMID 14553814 DOI: 10.1016/S0301-5629(03)00980-3  0.306
2004 Treat LH, McDannold NJ, Hynynen K. Transcranial MRI‐guided FUS‐induced BBB opening in the rat brain The Journal of the Acoustical Society of America. 115: 2524-2525. DOI: 10.1121/1.4783325  0.435
2004 Vykhodtseva N, McDannold N, Hynynen K. Ultrasound produced homogenization and liquefaction of brain tissue in vivo at pressures beyond the cavitation threshold The Journal of the Acoustical Society of America. 115: 2524-2524. DOI: 10.1121/1.4783321  0.402
2004 Hynynen K, Clement G, McDannold N, Vykhodtseva N, White PJ, Jolesz FA, Sheikov NA. The feasibility of noninvasive image‐guided treatments of brain disorders by focused ultrasound The Journal of the Acoustical Society of America. 115: 2446-2447. DOI: 10.1121/1.4782173  0.442
2003 Kuroda K, Takei N, Mulkern RV, Oshio K, Nakai T, Okada T, Matsumura A, Yanaka K, Hynynen K, Jolesz FA. Feasibility of internally referenced brain temperature imaging with a metabolite signal. Magnetic Resonance in Medical Sciences : Mrms : An Official Journal of Japan Society of Magnetic Resonance in Medicine. 2: 17-22. PMID 16210815 DOI: 10.2463/Mrms.2.17  0.322
2003 Huber PE, Mann MJ, Melo LG, Ehsan A, Kong D, Zhang L, Rezvani M, Peschke P, Jolesz F, Dzau VJ, Hynynen K. Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery. Gene Therapy. 10: 1600-7. PMID 12907952 DOI: 10.1038/Sj.Gt.3302045  0.325
2003 McDannold N, Moss M, Killiany R, Rosene DL, King RL, Jolesz FA, Hynynen K. MRI-guided focused ultrasound surgery in the brain: tests in a primate model. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 49: 1188-91. PMID 12768598 DOI: 10.1002/Mrm.10453  0.427
2003 Hynynen K, McDannold N, Martin H, Jolesz FA, Vykhodtseva N. The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison). Ultrasound in Medicine & Biology. 29: 473-81. PMID 12706199 DOI: 10.1016/S0301-5629(02)00741-X  0.424
2003 Jolesz FA, Talos IF, Schwartz RB, Mamata H, Kacher DF, Hynynen K, McDannold N, Saivironporn P, Zao L. Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors. Neuroimaging Clinics of North America. 12: 665-83. PMID 12687918 DOI: 10.1016/S1052-5149(02)00036-9  0.39
2003 King RL, Clement GT, Maruvada S, Hynynen K. Preliminary results using ultrasound transmission for image-guided thermal therapy Ultrasound in Medicine and Biology. 29: 293-299. PMID 12659917 DOI: 10.1016/S0301-5629(02)00707-X  0.339
2003 Tempany CM, Stewart EA, McDannold N, Quade BJ, Jolesz FA, Hynynen K. MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. Radiology. 226: 897-905. PMID 12616023 DOI: 10.1148/Radiol.2271020395  0.356
2003 Sokka SD, King R, Hynynen K. MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh. Physics in Medicine and Biology. 48: 223-41. PMID 12587906 DOI: 10.1088/0031-9155/48/2/306  0.343
2003 Connor CW, Hynynen K. Bio-acoustic thermal lensing and nonlinear propagation in focused ultrasound surgery using large focal spots: a parametric study. Physics in Medicine and Biology. 47: 1911-28. PMID 12108775 DOI: 10.1088/0031-9155/47/11/306  0.342
2003 Sassaroli E, Hynynen K. Forced linear oscillations of microbubbles in blood capillaries The Journal of the Acoustical Society of America. 114: 2320-2320. DOI: 10.1121/1.4780976  0.317
2003 Clement G, Hynynen K. Ultrasound phase‐contrast transmission imaging of localized thermal variation in a breast tissue model The Journal of the Acoustical Society of America. 113: 2324-2324. DOI: 10.1121/1.4780805  0.342
2003 Hynynen K, Clement G, McDannold N, Connor C, Vykhodtseva N. Large ultrasound phased arrays for noninvasive focal treatments The Journal of the Acoustical Society of America. 113: 2280-2280. DOI: 10.1121/1.4780573  0.365
2003 Fleury G, Lima DMd, Hynynen K, Berriet R, Baron OL, Huguenin B. New piezocomposite transducers for therapeutic ultrasound Biomedical Optics. 4954: 227-236. DOI: 10.1117/12.476626  0.333
2003 Vykhodtseva N, McDannold N, Hynynen K. Threshold damage induced during thermal therapy with focused ultrasound: histological investigation in the normal rabbit brain Ultrasound in Medicine & Biology. 29: S112. DOI: 10.1016/S0301-5629(03)00467-8  0.37
2003 Hynynen K. Magnetic resonance imaging-guided and monitored focused ultrasound surgery Ultrasound in Medicine & Biology. 29: S41. DOI: 10.1016/S0301-5629(03)00210-2  0.312
2003 McDannold N, Vykhodtseva N, Hynynen K. Threshold damage induced during thermal therapy with focused ultrasound: correlation with magnetic resonance imaging and thermometry Ultrasound in Medicine & Biology. 29: S32. DOI: 10.1016/S0301-5629(03)00176-5  0.319
2002 Clement GT, Hynynen K. Correlation of ultrasound phase with physical skull properties Ultrasound in Medicine and Biology. 28: 617-624. PMID 12079698 DOI: 10.1016/S0301-5629(02)00503-3  0.324
2002 Clement GT, Hynynen K. A non-invasive method for focusing ultrasound through the human skull Physics in Medicine and Biology. 47: 1219-1236. PMID 12030552 DOI: 10.1088/0031-9155/47/8/301  0.36
2002 Clement GT, Hynynen K. Micro-receiver guided transcranial beam steering Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 49: 447-453. PMID 11989700 DOI: 10.1109/58.996562  0.381
2002 Konofagou EE, Thierman J, Karjalainen T, Hynynen K. The temperature dependence of ultrasound-stimulated acoustic emission. Ultrasound in Medicine & Biology. 28: 331-8. PMID 11978413 DOI: 10.1016/S0301-5629(01)00525-7  0.312
2002 McDannold N, King RL, Jolesz FA, Hynynen K. The use of quantitative temperature images to predict the optimal power for focused ultrasound surgery: in vivo verification in rabbit muscle and brain. Medical Physics. 29: 356-65. PMID 11929019 DOI: 10.1118/1.1449495  0.324
2002 Vaughan TE, Hynynen K. Effects of parameter errors in the simulation of transcranial focused ultrasound Physics in Medicine and Biology. 47: 37-45. PMID 11814226 DOI: 10.1088/0031-9155/47/1/303  0.316
2002 Konofagou E, Thierman J, Hynynen K. A focused ultrasound method for simultaneous diagnostic and therapeutic applications--a simulation study. Physics in Medicine and Biology. 46: 2967-84. PMID 11720358 DOI: 10.1088/0031-9155/46/11/314  0.331
2002 Clement G, Hynynen K. A noninvasive method for focused ultrasound surgery through the human skull The Journal of the Acoustical Society of America. 111: 2414. DOI: 10.1121/1.4778236  0.37
2001 Smith NB, Temkin JM, Shapiro F, Hynynen K. Thermal effects of focused ultrasound energy on bone tissue Ultrasound in Medicine and Biology. 27: 1427-1433. PMID 11731056 DOI: 10.1016/S0301-5629(01)00454-9  0.302
2001 Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA. Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology. 220: 640-6. PMID 11526261 DOI: 10.1148/Radiol.2202001804  0.422
2001 Mahoney K, Fjield T, Mcdannold N, Clement G, Hynynen K. Comparison of modelled and observed in vivo temperature elevations induced by focused ultrasound: implications for treatment planning. Physics in Medicine and Biology. 46: 1785-98. PMID 11474925 DOI: 10.1088/0031-9155/46/7/304  0.307
2001 Hallaj IM, Cleveland RO, Hynynen K. Simulations of the thermo-acoustic lens effect during focused ultrasound surgery. The Journal of the Acoustical Society of America. 109: 2245-53. PMID 11386575 DOI: 10.1121/1.1360239  0.316
2001 Smith NB, Merrilees NK, Dahleh M, Hynynen K. Control system for an MRI compatible intracavitary ultrasound array for thermal treatment of prostate disease International Journal of Hyperthermia. 17: 271-282. PMID 11347731 DOI: 10.1080/02656730010025841  0.336
2001 McDannold N, Hynynen K, Oshio K, Mulkern RV. Temperature monitoring with line scan echo planar spectroscopic imaging Medical Physics. 28: 346-355. PMID 11318316 DOI: 10.1118/1.1350434  0.305
2001 Vykhodtseva N, Mcdannold N, Martin H, Bronson RT, Hynynen K. Apoptosis in ultrasound-produced threshold lesions in the rabbit brain Ultrasound in Medicine and Biology. 27: 111-117. PMID 11295277 DOI: 10.1016/S0301-5629(00)00275-1  0.373
2001 Hynynen K, Pomeroy O, Smith DN, Huber PE, McDannold NJ, Kettenbach J, Baum J, Singer S, Jolesz FA. MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: A feasibility study Radiology. 219: 176-185. PMID 11274554 DOI: 10.1148/Radiology.219.1.R01Ap02176  0.348
2001 Clement GT, Sun J, Hynynen K. Role of internal reflection in transskull phase distortion Ultrasonics. 39: 109-113. PMID 11270628 DOI: 10.1016/S0041-624X(00)00052-4  0.31
2001 McDannold N, Hynynen K, Jolesz F. MRI monitoring of the thermal ablation of tissue: effects of long exposure times. Journal of Magnetic Resonance Imaging : Jmri. 13: 421-7. PMID 11241817 DOI: 10.1002/Jmri.1061  0.33
2001 Hurwitz MD, Kaplan ID, Svensson GK, Hynynen K, Hansen MS. Feasibility and patient tolerance of a novel transrectal ultrasound hyperthermia system for treatment of prostate cancer. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 17: 31-7. PMID 11212878 DOI: 10.1080/02656730150201570  0.301
2001 Hynynen K, McDannold N, Vykhodtseva N, Sheikov N, Jolesz F. MRI guided focused ultrasound opening of blood brain barrier The Journal of the Acoustical Society of America. 110: 2642-2642. DOI: 10.1121/1.4776958  0.444
2001 Clement G, Hynynen K. Hydrophone guided transcranial beam steering The Journal of the Acoustical Society of America. 109: 2458-2458. DOI: 10.1121/1.4744719  0.399
2000 Clement GT, Sun J, Giesecke T, Hynynen K. A hemisphere array for non-invasive ultrasound brain therapy and surgery Physics in Medicine and Biology. 45: 3707-3719. PMID 11131194 DOI: 10.1088/0031-9155/45/12/314  0.377
2000 Vykhodtseva N, Sorrentino V, Jolesz FA, Bronson RT, Hynynen K. MRI detection of the thermal effects of focused ultrasound on the brain Ultrasound in Medicine and Biology. 26: 871-880. PMID 10942834 DOI: 10.1016/S0301-5629(00)00216-7  0.423
2000 Hynynen K, McDannold N, Mulkern RV, Jolesz FA. Temperature monitoring in fat with MRI Magnetic Resonance in Medicine. 43: 901-904. PMID 10861887 DOI: 10.1002/1522-2594(200006)43:6<901::Aid-Mrm18>3.0.Co;2-A  0.307
2000 Clement GT, White J, Hynynen K. Investigation of a large-area phased array for focused ultrasound surgery through the skull Physics in Medicine and Biology. 45: 1071-1083. PMID 10795992 DOI: 10.1088/0031-9155/45/4/319  0.355
2000 Clement G, Giesecke T, Hynynen K. Ultrasound‐induced transskull lesions using a large‐area phased array The Journal of the Acoustical Society of America. 107: 2814-2815. DOI: 10.1121/1.429076  0.327
1999 Daum DR, Smith NB, King R, Hynynen K. In vivo demonstration of noninvasive thermal surgery of the liver and kidney using an ultrasonic phased array Ultrasound in Medicine and Biology. 25: 1087-1098. PMID 10574341 DOI: 10.1016/S0301-5629(99)00053-8  0.313
1999 Chung AH, Jolesz FA, Hynynen K. Thermal dosimetry of a focused ultrasound beam in vivo by magnetic resonance imaging. Medical Physics. 26: 2017-26. PMID 10505893 DOI: 10.1118/1.598707  0.363
1999 Foldes K, Hynynen K, Shortkroff S, Winalski CS, Collucci V, Koskinen SK, McDannold N, Jolesz F. Magnetic resonance imaging-guided focused ultrasound synovectomy. Scandinavian Journal of Rheumatology. 28: 233-7. PMID 10503560 DOI: 10.1080/03009749950155607  0.323
1999 Diederich CJ, Hynynen K. Ultrasound technology for hyperthermia Ultrasound in Medicine and Biology. 25: 871-887. PMID 10461714 DOI: 10.1016/S0301-5629(99)00048-4  0.337
1999 Lee RJ, Buchanan M, Kleine LJ, Hynynen K. Arrays of multielement ultrasound applicators for interstitial hyperthermia. Ieee Transactions On Bio-Medical Engineering. 46: 880-90. PMID 10396906 DOI: 10.1109/10.771202  0.332
1999 Sun J, Hynynen K. The potential of transskull ultrasound therapy and surgery using the maximum available skull surface area. The Journal of the Acoustical Society of America. 105: 2519-27. PMID 10212433 DOI: 10.1121/1.426863  0.344
1999 Daum DR, Hynynen K. Theoretical design of a spherically sectioned phased array for ultrasound surgery of the liver. European Journal of Ultrasound. 9: 61-69. PMID 10099167 DOI: 10.1016/S0929-8266(99)00006-3  0.316
1999 Smith NB, Buchanan MT, Hynynen K. Transrectal ultrasound applicator for prostate heating monitored using MRI thermometry. International Journal of Radiation Oncology, Biology, Physics. 43: 217-25. PMID 9989529 DOI: 10.1016/S0360-3016(98)00366-6  0.329
1999 Clement G, Sun J, Giesecke T, Hynynen K. Ultrasound field correction in trans‐skull ultrasound surgery using a focused array The Journal of the Acoustical Society of America. 106: 2256-2256. DOI: 10.1121/1.427689  0.31
1999 Sun J, Clement G, Hynynen K. A hemisphere transducer array for transskull ultrasound therapy and surgery The Journal of the Acoustical Society of America. 106: 2230-2230. DOI: 10.1121/1.427582  0.318
1999 Hynynen K, Colucci V. In vivo ultrasound‐induced occlusion of arteries and veins The Journal of the Acoustical Society of America. 106: 2229-2229. DOI: 10.1121/1.427581  0.309
1998 Hutchinson EB, Hynynen K. Intracavitary ultrasound phased arrays for prostate thermal therapies: MRI compatibility and in vivo testing Medical Physics. 25: 2392-2399. PMID 9874833 DOI: 10.1118/1.598450  0.345
1998 Smith NB, Hynynen K. The feasibility of using focused ultrasound for transmyocardial revascularization Ultrasound in Medicine and Biology. 24: 1045-1054. PMID 9809638 DOI: 10.1016/S0301-5629(98)00086-6  0.303
1998 Sun J, Hynynen K. Focusing of therapeutic ultrasound through a human skull: a numerical study. The Journal of the Acoustical Society of America. 104: 1705-15. PMID 9745750 DOI: 10.1121/1.424383  0.394
1998 Mulkern RV, Panych LP, McDannold NJ, Jolesz FA, Hynynen K. Tissue temperature monitoring with multiple gradient-echo imaging sequences Journal of Magnetic Resonance Imaging. 8: 493-502. PMID 9562081 DOI: 10.1002/Jmri.1880080234  0.306
1998 Hynynen K, Jolesz FA. Demonstration of potential noninvasive ultrasound brain therapy through an intact skull. Ultrasound in Medicine & Biology. 24: 275-83. PMID 9550186 DOI: 10.1016/S0301-5629(97)00269-X  0.416
1998 Wong TZ, Silverman SG, Fielding JR, Tempany CM, Hynynen K, Jolesz FA. Open-configuration MR imaging, intervention, and surgery of the urinary tract. The Urologic Clinics of North America. 25: 113-22. PMID 9529542 DOI: 10.1016/S0094-0143(05)70438-9  0.319
1998 Mórocz IA, Hynynen K, Gudbjartsson H, Peled S, Colucci V, Jólesz FA. Brain edema development after MRI-guided focused ultrasound treatment. Journal of Magnetic Resonance Imaging : Jmri. 8: 136-42. PMID 9500273 DOI: 10.1002/Jmri.1880080126  0.427
1998 McDannold, Hynynen K, Wolf D, Wolf G, Jolesz F. MRI evaluation of thermal ablation of tumors with focused ultrasound. Journal of Magnetic Resonance Imaging : Jmri. 8: 91-100. PMID 9500266 DOI: 10.1002/Jmri.1880080119  0.384
1998 Hutchinson E, Dahleh M, Hynynen K. The feasibility of MRI feedback control for intracavitary phased array hyperthermia treatments. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 14: 39-56. PMID 9483445 DOI: 10.3109/02656739809018213  0.322
1998 Hynynen K, McDannold N, Fjield T, Daum D. MRI monitoring and control of focused ultrasound surgery The Journal of the Acoustical Society of America. 103: 2832-2832. DOI: 10.1121/1.421957  0.387
1998 Sun J, Hynynen K. A virtual source method for evaluating ultrasound propagation through tissues mapped from medical images The Journal of the Acoustical Society of America. 103: 2963-2963. DOI: 10.1121/1.421664  0.3
1997 Mulkern RV, Chung AH, Jolesz FA, Hynynen K. Temperature monitoring of ultrasonically heated muscle with RARE chemical shift imaging Medical Physics. 24: 1899-1906. PMID 9434972 DOI: 10.1118/1.598103  0.315
1997 Fjield T, Sorrentino V, Cline H, Hynynen K. Design and experimental verification of thin acoustic lenses for the coagulation of large tissue volumes. Physics in Medicine and Biology. 42: 2341-54. PMID 9434292 DOI: 10.1088/0031-9155/42/12/003  0.32
1997 Hynynen K, Dennie J, Zimmer JE, Simmons WN, He DS, Marcus FI, Aguirre M. Cylindrical ultrasonic transducers for cardiac catheter ablation Ieee Transactions On Biomedical Engineering. 44: 144-151. PMID 9214794 DOI: 10.1109/10.552244  0.302
1997 Hynynen K, Vykhodtseva NI, Chung AH, Sorrentino V, Colucci V, Jolesz FA. Thermal effects of focused ultrasound on the brain: determination with MR imaging. Radiology. 204: 247-53. PMID 9205255 DOI: 10.1148/Radiology.204.1.9205255  0.403
1997 Hynynen K, Colucci V, Chung A, Jolesz F. Noninvasive arterial occlusion using MRI-guided focused ultrasound. Ultrasound in Medicine & Biology. 22: 1071-7. PMID 9004431 DOI: 10.1016/S0301-5629(96)00143-3  0.335
1997 Fjield T, Hynynen K. The combined concentric-ring and sector-vortex phased array for MRI guided ultrasound surgery Ieee Transactions On Ultrasonics, Ferroelectrics and Frequency Control. 44: 1157-1167. DOI: 10.1109/58.655641  0.336
1996 Chung AH, Hynynen K, Colucci V, Oshio K, Cline HE, Jolesz FA. Optimization of spoiled gradient-echo phase imaging for in vivo localization of a focused ultrasound beam. Magnetic Resonance in Medicine. 36: 745-52. PMID 8916025 DOI: 10.1002/Mrm.1910360513  0.319
1996 Fan X, Hynynen K. Ultrasound surgery using multiple sonications--treatment time considerations. Ultrasound in Medicine & Biology. 22: 471-82. PMID 8795174 DOI: 10.1016/0301-5629(96)00026-9  0.341
1996 Fjield T, Fan X, Hynynen K. A parametric study of the concentric-ring transducer design for MRI guided ultrasound surgery. The Journal of the Acoustical Society of America. 100: 1220-30. PMID 8759971 DOI: 10.1121/1.416217  0.318
1996 Hynynen K, Chung AH, Colucci V, Jolesz FA. Potential adverse effects of high-intensity focused ultrasound exposure on blood vessels in vivo. Ultrasound in Medicine & Biology. 22: 193-201. PMID 8735529 DOI: 10.1016/0301-5629(95)02044-6  0.334
1996 Fan X, Hynynen K. A study of various parameters of spherically curved phased arrays for noninvasive ultrasound surgery. Physics in Medicine and Biology. 41: 591-608. PMID 8730659 DOI: 10.1088/0031-9155/41/4/002  0.301
1996 Cline HE, Hynynen K, Schneider E, Hardy CJ, Maier SE, Watkins RD, Jolesz FA. Simultaneous magnetic resonance phase and magnitude temperature maps in muscle. Magnetic Resonance in Medicine. 35: 309-15. PMID 8699941 DOI: 10.1002/Mrm.1910350307  0.315
1996 Vykhodtseva NI, Hynynen K, Damianou C. Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo. Ultrasound in Medicine & Biology. 21: 969-79. PMID 7491751 DOI: 10.1016/0301-5629(95)00038-S  0.355
1996 Hynynen K. Magnetic resonance imaging guided and monitored ultrasound surgery. The Journal of the Acoustical Society of America. 99: 2510-2529. DOI: 10.1121/1.415706  0.374
1996 Hynynen K, Chung A, Fjield T, Buchanan M, Daum D, Colucci V, Lopath P, Jolesz F. Feasibility of using ultrasound phased arrays for MRI monitored noninvasive surgery Ieee Transactions On Ultrasonics, Ferroelectrics and Frequency Control. 43: 1043-1053. DOI: 10.1109/58.542049  0.319
1996 Songhvi NT, Hynynen K, Lizzi FL. New developments in therapeutic ultrasound Ieee Engineering in Medicine and Biology Magazine. 15: 83-92. DOI: 10.1109/51.544515  0.344
1995 Vykhodtseva NI, Hynynen K, Damianou C. Pulse duration and peak intensity during focused ultrasound surgery: theoretical and experimental effects in rabbit brain in vivo. Ultrasound in Medicine & Biology. 20: 987-1000. PMID 7886858 DOI: 10.1016/0301-5629(94)90058-2  0.351
1995 Cline HE, Hynynen K, Watkins RD, Adams WJ, Schenck JF, Ettinger RH, Freund WR, Vetro JP, Jolesz FA. Focused US system for MR imaging-guided tumor ablation. Radiology. 194: 731-7. PMID 7862971 DOI: 10.1148/Radiology.194.3.7862971  0.35
1995 Hynynen K, Darkazanli A, Damianou CA, Unger E, Schenck JF. The usefulness of a contrast agent and gradient-recalled acquisition in a steady-state imaging sequence for magnetic resonance imaging-guided noninvasive ultrasound surgery. Investigative Radiology. 29: 897-903. PMID 7852041 DOI: 10.1097/00004424-199410000-00006  0.341
1995 Montes H, Hynynen K. A system for the simultaneous delivery of intraoperative radiation and ultrasound hyperthermia. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 11: 109-19. PMID 7714364 DOI: 10.3109/02656739509004952  0.317
1995 Hynynen K, Damianou CA, Colucci V, Unger E, Cline HH, Jolesz FA. MR monitoring of focused ultrasonic surgery of renal cortex: experimental and simulation studies. Journal of Magnetic Resonance Imaging : Jmri. 5: 259-66. PMID 7633101 DOI: 10.1002/Jmri.1880050306  0.347
1995 Fan X, Hynynen K. Control of the necrosed tissue volume during noninvasive ultrasound surgery using a 16-element phased array. Medical Physics. 22: 297-306. PMID 7596319 DOI: 10.1118/1.597603  0.337
1995 Zimmer JE, Hynynen K, He DS, Marcus F. The feasibility of using ultrasound for cardiac ablation. Ieee Transactions On Bio-Medical Engineering. 42: 891-7. PMID 7558063 DOI: 10.1109/10.412655  0.312
1995 Damianou CA, Hynynen K, Fan X. Evaluation of accuracy of a theoretical model for predicting the necrosed tissue volume during focused ultrasound surgery Ieee Transactions On Ultrasonics Ferroelectrics and Frequency Control. 42: 182-187. DOI: 10.1109/58.365232  0.305
1994 Damianou C, Hynynen K. The effect of various physical parameters on the size and shape of necrosed tissue volume during ultrasound surgery. The Journal of the Acoustical Society of America. 95: 1641-9. PMID 8176064 DOI: 10.1121/1.408550  0.312
1994 Fan X, Hynynen K. The effects of curved tissue layers on the power deposition patterns of therapeutic ultrasound beams. Medical Physics. 21: 25-34. PMID 8164584 DOI: 10.1118/1.597250  0.357
1994 Damianou C, Hynynen K. Focal spacing and near-field heating during pulsed high temperature ultrasound therapy. Ultrasound in Medicine & Biology. 19: 777-87. PMID 8134978 DOI: 10.1016/0301-5629(93)90094-5  0.348
1994 Cline HE, Hynynen K, Hardy CJ, Watkins RD, Schenck JF, Jolesz FA. MR temperature mapping of focused ultrasound surgery. Magnetic Resonance in Medicine. 31: 628-36. PMID 8057815 DOI: 10.1002/Mrm.1910310608  0.353
1994 Buchanan MT, Hynynen K. Design and experimental evaluation of an intracavitary ultrasound phased array system for hyperthermia. Ieee Transactions On Bio-Medical Engineering. 41: 1178-87. PMID 7851919 DOI: 10.1109/10.335866  0.311
1994 Tu SJ, Hynynen K, Roemer RB. Simulation of bidirectional ultrasound hyperthermia treatments of neck tumours International Journal of Hyperthermia. 10: 707-722. PMID 7806926 DOI: 10.3109/02656739409022449  0.326
1993 Hynynen K, Davis KL. Small cylindrical ultrasound sources for induction of hyperthermia via body cavities or interstitial implants International Journal of Hyperthermia. 9: 263-274. PMID 8468509 DOI: 10.3109/02656739309022539  0.332
1993 Hynynen K, Damianou C, Darkazanli A, Unger E, Schenck JF. The feasibility of using MRI to monitor and guide noninvasive ultrasound surgery. Ultrasound in Medicine & Biology. 19: 91-2. PMID 8456533 DOI: 10.1016/0301-5629(93)90022-G  0.309
1993 Hynynen K, Darkazanli A, Unger E, Schenck JF. MRI-guided noninvasive ultrasound surgery. Medical Physics. 20: 107-15. PMID 8455489 DOI: 10.1118/1.597093  0.355
1993 Cline HE, Schenck JF, Watkins RD, Hynynen K, Jolesz FA. Magnetic resonance-guided thermal surgery. Magnetic Resonance in Medicine. 30: 98-106. PMID 8371680 DOI: 10.1002/Mrm.1910300115  0.334
1992 Hynynen K. The role of nonlinear ultrasound propagation during hyperthermia treatments. Medical Physics. 18: 1156-63. PMID 1753899 DOI: 10.1118/1.596626  0.311
1992 Fan X, Hynynen K. The effect of wave reflection and refraction at soft tissue interfaces during ultrasound hyperthermia treatments. The Journal of the Acoustical Society of America. 91: 1727-36. PMID 1564208 DOI: 10.1121/1.402452  0.318
1992 Dorr LN, Hynynen K. The effects of tissue heterogeneities and large blood vessels on the thermal exposure induced by short high-power ultrasound pulses. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 8: 45-59. PMID 1545163 DOI: 10.3109/02656739209052878  0.334
1992 Hynynen K. The feasibility of interstitial ultrasound hyperthermia. Medical Physics. 19: 979-87. PMID 1518487 DOI: 10.1118/1.596786  0.355
1992 Cline HE, Schenck JF, Hynynen K, Watkins RD, Souza SP, Jolesz FA. MR-guided focused ultrasound surgery. Journal of Computer Assisted Tomography. 16: 956-65. PMID 1430448 DOI: 10.1097/00004728-199211000-00024  0.334
1991 Hynynen K. Hot spots created at skin-air interfaces during ultrasound hyperthermia. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 6: 1005-12. PMID 2286789 DOI: 10.3109/02656739009140983  0.31
1991 Hynynen K. The threshold for thermally significant cavitation in dog's thigh muscle in vivo. Ultrasound in Medicine & Biology. 17: 157-69. PMID 2053212 DOI: 10.1016/0301-5629(91)90123-E  0.335
1991 Diederich CJ, Hynynen K. The Feasibility of Using Electrically Focused Ultrasound Arrays to Induce Deep Hyperthermia Via Body Cavities Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 38: 207-219. DOI: 10.1109/58.79605  0.321
1990 Billard BE, Hynynen K, Roemer RB. Effects of physical parameters on high temperature ultrasound hyperthermia Ultrasound in Medicine and Biology. 16: 409-420. PMID 2396329 DOI: 10.1016/0301-5629(90)90070-S  0.334
1990 Johnson C, Kress R, Roemer R, Hynynen K. Multi-point feedback control system for scanned, focused ultrasound hyperthermia Physics in Medicine and Biology. 35: 781-786. PMID 2367547 DOI: 10.1088/0031-9155/35/6/007  0.307
1990 Moros EG, Roemer RB, Hynynen K. Pre-focal plane high-temperature regions induced by scanning focused ultrasound beams International Journal of Hyperthermia. 6: 351-366. PMID 2324574 DOI: 10.3109/02656739009141143  0.31
1990 Anhalt D, Hynynen K, DeYoung D, Shimm D, Kundrat M, Cetas T. The CDRH Helix: an in vivo evaluation. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 6: 241-52. PMID 2299236 DOI: 10.3109/02656739009140819  0.302
1990 Diederich CJ, Hynynen K. The development of intracavitary ultrasonic applicators for hyperthermia: A design and experimental study Medical Physics. 17: 626-634. PMID 2215407 DOI: 10.1118/1.596582  0.309
1990 Lin WL, Roemer RB, Hynynen K. Theoretical and experimental evaluation of a temperature controller for scanned focused ultrasound hyperthermia Medical Physics. 17: 615-625. PMID 2215406 DOI: 10.1118/1.596581  0.301
1990 Hynynen K, Lulu BA. Hyperthermia in cancer treatment. Investigative Radiology. 25: 824-34. PMID 2202694 DOI: 10.1097/00004424-199007000-00014  0.343
1989 Hynynen K, DeYoung D, Kundrat M, Moros E. The effect of blood perfusion rate on the temperature distributions induced by multiple, scanned and focused ultrasonic beams in dogs' kidneys in vivo. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 5: 485-97. PMID 2746052 DOI: 10.3109/02656738909140473  0.315
1988 Moros EG, Roemer RB, Hynynen K. Simulations of Scanned Focused Ultrasound Hyperthermia: The Effects of Scanning Speed and Pattern on the Temperature Fluctuations at the Focal Depth Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 35: 552-560. DOI: 10.1109/58.8033  0.319
1987 Hynynen K. Demonstration of enhanced temperature elevation due to nonlinear propagation of focussed ultrasound in dog's thigh in vivo. Ultrasound in Medicine & Biology. 13: 85-91. PMID 3590364 DOI: 10.1016/0301-5629(87)90078-0  0.31
1987 Tobias J, Hynynen K, Roemer R, Guthkelch AN, Fleischer AS, Shively J. An ultrasound window to perform scanned, focused ultrasound hyperthermia treatments of brain tumors Medical Physics. 14: 228-234. PMID 3587144 DOI: 10.1118/1.596074  0.362
1987 Shimm D, Hynynen K, Roemer R, Cassady J. Scanned focused ultrasound hyperthermia: Preliminary results International Journal of Radiation Oncology*Biology*Physics. 13: 138. DOI: 10.1016/0360-3016(87)91114-X  0.346
1986 Hynynen K, Roemer R, Moros E, Johnson C, Anhalt D. The Effect of Scanning Speed on Temperature and Equivalent Thermal Exposure Distributions During Ultrasound Hyperthermia In Vivo Ieee Transactions On Microwave Theory and Techniques. 34: 552-559. DOI: 10.1109/Tmtt.1986.1133391  0.312
1983 Hynynen K, Watmough DJ, Mallard JR, Fuller M. The construction and assessment of lenses for local treatment of malignant tumours by ultrasound. Ultrasound in Medicine & Biology. 9: 33-8. PMID 6879823 DOI: 10.1016/0301-5629(83)90107-2  0.339
1981 Hynynen K, Watmough DJ, Mallard JR. The effects of some physical factors on the production of hyperthermia by ultrasound in neoplastic tissues. Radiation and Environmental Biophysics. 19: 215-26. PMID 7267988 DOI: 10.1007/Bf01324189  0.309
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