Junho Hur, Ph.D.

Affiliations: 
2012 Johns Hopkins University, Baltimore, MD 
Area:
translation of the genetic code
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"Junho Hur"

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Rachel Green grad student 2012 Johns Hopkins
 (Interactions between RNA and Argonaute protein in RNAi and translational repression.)
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Publications

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Kim H, Lee WJ, Kim CH, et al. (2022) Highly specific chimeric DNA-RNA-guided genome editing with enhanced CRISPR-Cas12a system. Molecular Therapy. Nucleic Acids. 28: 353-362
Kim H, Lee WJ, Oh Y, et al. (2020) Enhancement of target specificity of CRISPR-Cas12a by using a chimeric DNA-RNA guide. Nucleic Acids Research
Hur JK, Chung YD. (2016) A novel model of THO/TREX loading onto target RNAs in metazoan gene expression. Bmb Reports
Hur JK, Luo Y, Moon S, et al. (2016) Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila. Genes & Development. 30: 840-55
Webster A, Li S, Hur JK, et al. (2015) Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper. Molecular Cell. 59: 564-75
Hur JK, Olovnikov I, Aravin AA. (2014) Prokaryotic Argonautes defend genomes against invasive DNA. Trends in Biochemical Sciences. 39: 257-9
Le Thomas A, Rogers AK, Webster A, et al. (2013) Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Genes & Development. 27: 390-9
Hur JK, Zinchenko MK, Djuranovic S, et al. (2013) Regulation of Argonaute slicer activity by guide RNA 3' end interactions with the N-terminal lobe. The Journal of Biological Chemistry. 288: 7829-40
Djuranovic S, Zinchenko MK, Hur JK, et al. (2010) Allosteric regulation of Argonaute proteins by miRNAs. Nature Structural & Molecular Biology. 17: 144-50
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