John FX Diffley
Affiliations: | DNA replication Laboratory | Cancer Research UK - Clare Hall, Cambridge, England, United Kingdom |
Area:
DNA ReplicationWebsite:
http://science.cancerresearchuk.org/sci/chromrep/Google:
"John Diffley"Collaborators
Sign in to add collaborator| Orly Alter | collaborator | 2009 | Francis Crick Institute (Physics Tree) |
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Publications
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| McClure A, Diffley J. (2021) Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation. Elife. 10 |
| Zhou JC, Janska A, Goswami P, et al. (2017) CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome. Proceedings of the National Academy of Sciences of the United States of America |
| Yeeles JT, Janska A, Early A, et al. (2016) How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication. Molecular Cell |
| Kurat CF, Yeeles JT, Patel H, et al. (2016) Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates. Molecular Cell |
| Deegan TD, Yeeles JT, Diffley JF. (2016) Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation. The Embo Journal |
| Deegan TD, Diffley JF. (2016) MCM: one ring to rule them all. Current Opinion in Structural Biology. 37: 145-151 |
| Douglas ME, Diffley JF. (2015) Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the MCM Complex. The Journal of Biological Chemistry |
| Yeeles JT, Deegan TD, Janska A, et al. (2015) Regulated eukaryotic DNA replication origin firing with purified proteins. Nature. 519: 431-5 |
| Morafraile EC, Diffley JF, Tercero JA, et al. (2015) Checkpoint-dependent RNR induction promotes fork restart after replicative stress. Scientific Reports. 5: 7886 |
| Coster G, Frigola J, Beuron F, et al. (2014) Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase. Molecular Cell. 55: 666-77 |