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Youla Tsantrizos, Ph.D. - Publications

Affiliations: 
1997- Chemistry McGill University, Montreal, QC, Canada 
Area:
Crystallography
Website:
http://tsantrizos-group.mcgill.ca/tsantrizos.html
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lee HF, Lacbay CM, Boutin R, Matralis AN, Park J, Waller DD, Guan TL, Sebag M, Tsantrizos YS. Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. Journal of Medicinal Chemistry. PMID 35077178 DOI: 10.1021/acs.jmedchem.1c01913  0.321
2017 Park J, Rodionov D, De Schutter JW, Lin YS, Tsantrizos YS, Berghuis AM. Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. Plos One. 12: e0186447. PMID 29036218 DOI: 10.1371/Journal.Pone.0186447  0.483
2016 Fader LD, Bailey M, Beaulieu E, Bilodeau F, Bonneau P, Bousquet Y, Carson RJ, Chabot C, Coulombe R, Duan J, Fenwick C, Garneau M, Halmos T, Jakalian A, James C, ... ... Tsantrizos Y, et al. Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs. Acs Medicinal Chemistry Letters. 7: 797-801. PMID 27563405 DOI: 10.1021/Acsmedchemlett.6B00194  0.717
2016 Jansen G, Golizeh M, Martel-Lorion C, Dejgaard K, Shiao TC, Mancuso J, Tsantrizos YS, Roy R, Sebag M, Sleno L, Thomas DY, Waller DD. A covalent cysteine-targeting kinase inhibitor of Ire1 permits allosteric control of endoribonuclease activity. Chembiochem : a European Journal of Chemical Biology. PMID 26792008 DOI: 10.1002/Cbic.201500485  0.548
2015 Fandrick KR, Li W, Zhang Y, Tang W, Gao J, Rodriguez S, Patel ND, Reeves DC, Wu JP, Sanyal S, Gonnella N, Qu B, Haddad N, Lorenz JC, Sidhu K, ... ... Tsantrizos Y, et al. Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor. Angewandte Chemie (International Ed. in English). 54: 7144-8. PMID 25939331 DOI: 10.1002/Anie.201501575  0.339
2015 Gritzalis D, Park J, Chiu W, Cho H, Lin YS, De Schutter JW, Lacbay CM, Zielinski M, Berghuis AM, Tsantrizos YS. Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. Bioorganic & Medicinal Chemistry Letters. 25: 1117-23. PMID 25630225 DOI: 10.1016/J.Bmcl.2014.12.089  0.446
2014 Lacbay CM, Mancuso J, Lin YS, Bennett N, Götte M, Tsantrizos YS. Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase. Journal of Medicinal Chemistry. 57: 7435-49. PMID 25144111 DOI: 10.1021/Jm501010F  0.657
2014 Fader LD, Carson R, Morin S, Bilodeau F, Chabot C, Halmos T, Bailey MD, Kawai SH, Coulombe R, Laplante S, Mekhssian K, Jakalian A, Garneau M, Duan J, Mason SW, ... ... Tsantrizos Y, et al. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. Acs Medicinal Chemistry Letters. 5: 711-6. PMID 24944749 DOI: 10.1021/Ml500110J  0.743
2014 De Schutter JW, Park J, Leung CY, Gormley P, Lin YS, Hu Z, Berghuis AM, Poirier J, Tsantrizos YS. Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. Journal of Medicinal Chemistry. 57: 5764-76. PMID 24911527 DOI: 10.1021/Jm500629E  0.432
2014 Fader LD, Malenfant E, Parisien M, Carson R, Bilodeau F, Landry S, Pesant M, Brochu C, Morin S, Chabot C, Halmos T, Bousquet Y, Bailey MD, Kawai SH, Coulombe R, ... ... Tsantrizos Y, et al. Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1. Acs Medicinal Chemistry Letters. 5: 422-7. PMID 24900852 DOI: 10.1021/Ml500002N  0.71
2014 Fenwick C, Amad M, Bailey MD, Bethell R, Bös M, Bonneau P, Cordingley M, Coulombe R, Duan J, Edwards P, Fader LD, Faucher AM, Garneau M, Jakalian A, Kawai S, ... ... Tsantrizos Y, et al. Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor. Antimicrobial Agents and Chemotherapy. 58: 3233-44. PMID 24663024 DOI: 10.1128/Aac.02719-13  0.724
2014 Park J, Lin YS, Tsantrizos YS, Berghuis AM. Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallographica. Section F, Structural Biology Communications. 70: 299-304. PMID 24598914 DOI: 10.1107/S2053230X14002106  0.459
2014 Park J, Leung C, Lin Y, De Schutter J, Tsantrizos Y, Berghuis A. Crystal structures of hFPPS in complex with novel anticancer drug leads Acta Crystallographica Section a Foundations and Advances. 70: C712-C712. DOI: 10.1107/S2053273314092870  0.551
2013 Stammers TA, Coulombe R, Rancourt J, Thavonekham B, Fazal G, Goulet S, Jakalian A, Wernic D, Tsantrizos Y, Poupart MA, Bös M, McKercher G, Thauvette L, Kukolj G, Beaulieu PL. Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 2585-9. PMID 23545108 DOI: 10.1016/J.Bmcl.2013.02.110  0.348
2013 Leung CY, Langille AM, Mancuso J, Tsantrizos YS. Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase--parallel synthesis of analogs via a trimethylsilyl ylidene intermediate. Bioorganic & Medicinal Chemistry. 21: 2229-40. PMID 23477945 DOI: 10.1016/J.Bmc.2013.02.006  0.588
2012 Park J, Lin YS, De Schutter JW, Tsantrizos YS, Berghuis AM. Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Structural Biology. 12: 32. PMID 23234314 DOI: 10.1186/1472-6807-12-32  0.479
2012 De Schutter JW, Shaw J, Lin YS, Tsantrizos YS. Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls. Bioorganic & Medicinal Chemistry. 20: 5583-91. PMID 22884353 DOI: 10.1016/J.Bmc.2012.07.019  0.477
2012 Lin YS, Park J, De Schutter JW, Huang XF, Berghuis AM, Sebag M, Tsantrizos YS. Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. Journal of Medicinal Chemistry. 55: 3201-15. PMID 22390415 DOI: 10.1021/Jm201657X  0.462
2010 TSANTRIZOS YS, OGILVIE KK, WATSON AK. ChemInform Abstract: Phytotoxic Metabolites of Phomopsis convolvulus, a Host-Specific Pathogen of Field Bindweed. Cheminform. 24: no-no. DOI: 10.1002/chin.199313300  0.414
2010 TSANTRIZOS YS, FOLKINS PL, BRITTEN JF, HARPP DN, OGILVIE KK. ChemInform Abstract: Approaches Towards the Synthesis of a Sulfur Analogue of Ergosterol Peroxide. Cheminform. 23: no-no. DOI: 10.1002/chin.199236249  0.478
2005 Fader LD, Tsantrizos YS. Modifications of peptide nucleic acid (PNA) monomers as a strategy for modulating the physicochemical and pharmacokinetic properties of PNA oligomers Chimica Oggi. 23: 40-44.  0.691
2004 Fader LD, Myers EL, Tsantrizos YS. Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties Tetrahedron. 60: 2235-2246. DOI: 10.1016/J.Tet.2004.01.026  0.721
2002 Fader LD, Tsantrizos YS. Hybridization properties of aromatic peptide nucleic acids: a novel class of oligonucleotide analogues. Organic Letters. 4: 63-6. PMID 11772091 DOI: 10.1021/ol010231q  0.694
2001 Fader LD, Boyd M, Tsantrizos YS. Backbone modifications of aromatic peptide nucleic acid (APNA ) monomers and their hybridization properties with DNA and RNA. The Journal of Organic Chemistry. 66: 3372-9. PMID 11348119 DOI: 10.1021/jo001650o  0.702
2000 Tsantrizos YS, Yang XS. Chapter Four Macrolide and polyether polyketides biosynthesis and molecular diversity Recent Advances in Phytochemistry. 34: 91-107. DOI: 10.1016/S0079-9920(00)80005-2  0.347
1999 Tsantrizos YS, Yang X, McClory A. Studies on the Biosynthesis of the Fungal Metabolite Oudenone. 2. Synthesis and Enzymatic Cyclization of an alpha-Diketone, Open-Chain Precursor into Oudenone in Cultures of Oudemansiella radicata. The Journal of Organic Chemistry. 64: 6609-6614. PMID 11674663 DOI: 10.1021/Jo9901135  0.323
1997 Cane DE, Xue Q, Van Epp JE, Tsantrizos YS. Enzymatic Formation of Isochamigrene, a Novel Sesquiterpene, by Alteration of the Aspartate-Rich Region of Trichodiene SynthaseJ. Am. Chem. Soc.1996,118, 8499−8500 Journal of the American Chemical Society. 119: 7905-7905. DOI: 10.1021/Ja975410A  0.411
1997 Tsantrizos YS, Lunetta JF, Boyd M, Fader LD, Wilson MC. Stereoselective Synthesis of a Thymine Derivative of (S)-2-Hydroxy-4-(2-aminophenyl)butanoic Acid. A Novel Building Block for the Synthesis of Aromatic Peptidic Nucleic Acid Oligomers Journal of Organic Chemistry. 62: 5451-5457.  0.704
1996 Cane DE, Tsantrizos YS. Aristolochene synthase. Elucidation of the cryptic germacrene A synthase activity using the anomalous substrate dihydrofarnesyl diphosphate Journal of the American Chemical Society. 118: 10037-10040. DOI: 10.1021/ja961981b  0.4
1996 Cane DE, Xue Q, Van Epp JE, Tsantrizos YS. Enzymatic formation of isochamigrene, a novel sesquiterpene, by alteration of the aspartate-rich region of trichodiene synthase Journal of the American Chemical Society. 118: 8499-8500. DOI: 10.1021/Ja961897W  0.42
1992 Tsantrizos YS, Ogilvie KK, Watson AK. Phytotoxic metabolites of Phomopsisconvolvulus, a host-specific pathogen of field bindweed Canadian Journal of Chemistry. 70: 2276-2284. DOI: 10.1139/v92-286  0.501
1992 Tsantrizos YS, Folkins PL, Britten JF, Harpp DN, Ogilvie KK. Approaches towards the synthesis of a sulfur analog of ergosterol peroxide Canadian Journal of Chemistry. 70: 158-164. DOI: 10.1139/v92-026  0.467
1991 Kope HH, Tsantrizos YS, Fortin JA, Ogilvie KK. p-Hydroxybenzoylformic acid and (R)-(-)-p-hydroxymandelic acid, two antifungal compounds isolated from the liquid culture of the ectomycorrhizal fungus Pisolithus arhizus. Canadian Journal of Microbiology. 37: 258-64. PMID 1913337  0.691
1991 Tsantrizos YS, Kope HH, Fortin JA, Ogilvie KK. Antifungal antibiotics from Pisolithus tinctorius Phytochemistry. 30: 1113-1118. DOI: 10.1016/S0031-9422(00)95183-5  0.402
1991 Tsantrizos YS, Ogilvie KK. Determination of the absolute stereochemistry of the fungal metabolite (R)-(-)-2-(4'-hydroxyphenyl)-2-hydroxyethanoic acid (pisolithin B) Canadian Journal of Chemistry. 69: 772-778.  0.468
1981 Just G, Tsantrizos YS, Ugolini A. β-Lactams. IX. The synthesis of 7-β-phenylacetamido-3'-hydroxybenzo-[3,4]-O-2-isocephem, a weak antibacterial β-lactam antibiotic Canadian Journal of Chemistry. 59: 2981-2987. DOI: 10.1002/Chin.198209348  0.382
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