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Ee L. Ang, Ph.D. - Publications

Affiliations: 
University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
Directed evolution, metabolic engineering, natural product, gene therapy, synthetic biology
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Peh G, Tay T, Tan LL, Tiong E, Bi J, Goh YL, Ye S, Lin F, Tan CJX, Tan YZ, Wong J, Zhao H, Wong FT, Ang EL, Lim YH. Site-selective chlorination of pyrrolic heterocycles by flavin dependent enzyme PrnC. Communications Chemistry. 7: 7. PMID 38182798 DOI: 10.1038/s42004-023-01083-1  0.404
2023 Peh G, Gunawan GA, Tay T, Tiong E, Tan LL, Jiang S, Goh YL, Ye S, Wong J, Brown CJ, Zhao H, Ang EL, Wong FT, Lim YH. Further Characterization of Fungal Halogenase RadH and Its Homologs. Biomolecules. 13. PMID 37509117 DOI: 10.3390/biom13071081  0.373
2023 Cheong CB, Peh G, Wei Y, T R, Ang EL, Zhao H, Zhang C, Lim YH. A Spirobicyclo[3.1.0]Terpene from the Investigation of Sesquiterpene Synthases from . Acs Chemical Biology. PMID 36594743 DOI: 10.1021/acschembio.2c00760  0.472
2022 Zhao F, Wei Y, Wang X, Zhou Y, Tong Y, Ang EL, Liu S, Zhao H, Zhang Y. Enzymatic Synthesis of the Unnatural Nucleotide 2'-Deoxyisoguanosine 5'-Monophosphate. Chembiochem : a European Journal of Chemical Biology. PMID 35959532 DOI: 10.1002/cbic.202200295  0.381
2022 Duan Y, Wei Y, Xing M, Liu J, Jiang L, Lu Q, Liu X, Liu Y, Ang EL, Liao RZ, Yuchi Z, Zhao H, Zhang Y. Anaerobic Hydroxyproline Degradation Involving C-N Cleavage by a Glycyl Radical Enzyme. Journal of the American Chemical Society. PMID 35611954 DOI: 10.1021/jacs.2c01673  0.442
2022 Liu Y, Wei Y, Teh TM, Liu D, Zhou Y, Zhao S, Ang EL, Zhao H, Zhang Y. Identification and Characterization of the Biosynthetic Pathway of the Sulfonolipid Capnine. Biochemistry. PMID 35414181 DOI: 10.1021/acs.biochem.2c00102  0.427
2022 Liang J, Zhang H, Tan YL, Zhao H, Ang EL. Directed Evolution of Replication-Competent Double-Stranded DNA Bacteriophage toward New Host Specificity. Acs Synthetic Biology. 11: 634-643. PMID 35090114 DOI: 10.1021/acssynbio.1c00319  0.38
2021 Zhou Y, Xu X, Wei Y, Cheng Y, Guo Y, Khudyakov I, Liu F, He P, Song Z, Li Z, Gao Y, Ang EL, Zhao H, Zhang Y, Zhao S. A widespread pathway for substitution of adenine by diaminopurine in phage genomes. Science (New York, N.Y.). 372: 512-516. PMID 33926954 DOI: 10.1126/science.abe4882  0.387
2020 Liu Y, Wei Y, Zhou Y, Ang EL, Zhao H, Zhang Y. A transaldolase-dependent sulfoglycolysis pathway in Bacillus megaterium DSM 1804. Biochemical and Biophysical Research Communications. PMID 33036753 DOI: 10.1016/j.bbrc.2020.09.124  0.388
2020 Wang F, Wei Y, Lu Q, Ang EL, Zhao H, Zhang Y. A ferredoxin-dependent dihydropyrimidine dehydrogenase in Clostridium chromiireducens. Bioscience Reports. 40. PMID 32614053 DOI: 10.1042/Bsr20201642  0.471
2020 Liu J, Wei Y, Lin L, Teng L, Yin J, Lu Q, Chen J, Zheng Y, Li Y, Xu R, Zhai W, Liu Y, Liu Y, Cao P, Ang EL, et al. Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate. Proceedings of the National Academy of Sciences of the United States of America. PMID 32571930 DOI: 10.1073/Pnas.2003434117  0.516
2020 Xu W, Klumbys E, Ang EL, Zhao H. Emerging molecular biology tools and strategies for engineering natural product biosynthesis. Metabolic Engineering Communications. 10: e00108. PMID 32547925 DOI: 10.1016/J.Mec.2019.E00108  0.506
2020 Sun H, Zhao H, Ang EL. A new biosensor for stilbenes and a cannabinoid enabled by genome mining of a transcriptional regulator. Acs Synthetic Biology. PMID 32078771 DOI: 10.1021/Acssynbio.9B00443  0.499
2020 Zhu D, Wei Y, Yin J, Liu D, Ang EL, Zhao H, Zhang Y. A pathway for degradation of uracil to acetyl coenzyme A in . Applied and Environmental Microbiology. PMID 31953335 DOI: 10.1128/Aem.02837-19  0.491
2020 Yeo WL, Heng E, Tan LL, Lim YW, Ching KC, Tsai DJ, Jhang YW, Lauderdale TL, Shia KS, Zhao H, Ang EL, Zhang MM, Lim YH, Wong FT. Biosynthetic engineering of the antifungal, anti-MRSA auroramycin. Microbial Cell Factories. 19: 3. PMID 31906943 DOI: 10.1186/S12934-019-1274-Y  0.484
2019 Wei Y, Tan YL, Ang EL, Zhao H. Identification and Characterization of Citrus Peel  Uronic Acid Oxidase. Chembiochem : a European Journal of Chemical Biology. PMID 31587437 DOI: 10.1002/Cbic.201900546  0.438
2019 Yin J, Wei Y, Liu D, Hu Y, Lu Q, Ang EL, Zhao H, Zhang Y. An extended bacterial reductive pyrimidine degradation pathway that enables nitrogen release from β-alanine. The Journal of Biological Chemistry. PMID 31455636 DOI: 10.1074/Jbc.Ra119.010406  0.506
2019 Xing M, Wei Y, Hua G, Li M, Nanjaraj Urs AN, Wang F, Hu Y, Zhai W, Liu Y, Ang EL, Zhao H, Zhang Y. A gene cluster for taurine sulfur assimilation in an anaerobic human gut bacterium. The Biochemical Journal. PMID 31350331 DOI: 10.1042/Bcj20190486  0.479
2019 Tong Y, Wei Y, Hu Y, Ang EL, Zhao H, Zhang Y. A pathway for isethionate dissimilation in . Applied and Environmental Microbiology. PMID 31126948 DOI: 10.1128/Aem.00793-19  0.511
2019 Zhou Y, Wei Y, Nanjaraj Urs AN, Lin L, Xu T, Hu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y. Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacterium . Bioscience Reports. PMID 31123167 DOI: 10.1042/Bsr20190715  0.493
2019 Li M, Wei Y, Yin J, Lin L, Zhou Y, Hua G, Cao P, Ang EL, Zhao H, Yuchi Z, Zhang Y. Biochemical and structural investigation of taurine:2-oxoglutarate aminotransferase from . The Biochemical Journal. PMID 31088892 DOI: 10.1042/Bcj20190206  0.51
2019 Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, et al. Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria. Nature Communications. 10: 1609. PMID 30962433 DOI: 10.1038/S41467-019-09618-8  0.505
2019 Shi S, Liang Y, Ang EL, Zhao H. Delta Integration CRISPR-Cas (Di-CRISPR) in Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 1927: 73-91. PMID 30788786 DOI: 10.1007/978-1-4939-9142-6_6  0.437
2019 Zhou Y, Wei Y, Lin L, Xu T, Ang EL, Zhao H, Yuchi Z, Zhang Y. Biochemical and structural investigation of sulfoacetaldehyde reductase from . The Biochemical Journal. PMID 30718306 DOI: 10.1042/Bcj20190005  0.461
2018 Liu D, Wei Y, Liu X, Zhou Y, Jiang L, Yin J, Wang F, Hu Y, Nanjaraj Urs AN, Liu Y, Ang EL, Zhao S, Zhao H, Zhang Y. Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole. Nature Communications. 9: 4224. PMID 30310076 DOI: 10.1038/S41467-018-06627-X  0.51
2018 Sun H, Zhao H, Ang EL. A coupled chlorinase-fluorinase system with a high efficiency of trans-halogenation and a shared substrate tolerance. Chemical Communications (Cambridge, England). PMID 30083673 DOI: 10.1039/C8Cc04436H  0.45
2018 Zhao H, Lim YH, Wong FT, Yeo WL, Ching KC, Lim YW, Heng E, Chen S, Tsai DJ, Lauderdale TL, Shia KS, Ho YS, Hoon S, Ang EL, Zhang MM. Auroramycin, a potent antibiotic from Streptomyces roseosporus by CRISPR-Cas9 activation. Chembiochem : a European Journal of Chemical Biology. PMID 29799651 DOI: 10.1002/Cbic.201800266  0.423
2018 Tapsin S, Sun M, Shen Y, Zhang H, Lim XN, Susanto TT, Yang SL, Zeng GS, Lee J, Lezhava A, Ang EL, Zhang LH, Wang Y, Zhao H, Nagarajan N, et al. Genome-wide identification of natural RNA aptamers in prokaryotes and eukaryotes. Nature Communications. 9: 1289. PMID 29599443 DOI: 10.1038/S41467-018-03675-1  0.38
2018 Shi S, Ang EL, Zhao H. In vivo biosensors: mechanisms, development, and applications. Journal of Industrial Microbiology & Biotechnology. PMID 29380152 DOI: 10.1007/S10295-018-2004-X  0.477
2017 Wei Y, Ang EL, Zhao H. Recent developments in the application of P450 based biocatalysts. Current Opinion in Chemical Biology. 43: 1-7. PMID 29100098 DOI: 10.1016/J.Cbpa.2017.08.006  0.445
2017 Shi S, Choi YW, Zhao H, Tan MH, Ang EL. Discovery and engineering of a 1-butanol biosensor in Saccharomyces cerevisiae. Bioresource Technology. PMID 28712783 DOI: 10.1016/J.Biortech.2017.06.114  0.481
2017 Sun H, Zhang H, Ang EL, Zhao H. Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates. Bioorganic & Medicinal Chemistry. PMID 28709846 DOI: 10.1016/J.Bmc.2017.06.043  0.476
2017 Zhang MM, Wong FT, Wang Y, Luo S, Lim YH, Heng E, Yeo WL, Cobb RE, Enghiad B, Ang EL, Zhao H. CRISPR-Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters. Nature Chemical Biology. PMID 28398287 DOI: 10.1038/Nchembio.2341  0.45
2017 Liang J, Liu Z, Low XZ, Ang EL, Zhao H. Twin-primer non-enzymatic DNA assembly: an efficient and accurate multi-part DNA assembly method. Nucleic Acids Research. PMID 28334760 DOI: 10.1093/Nar/Gkx132  0.404
2017 Zhang MM, Yuan Q, Ang EL, Zhao H. Using natural products for drug discovery: the impact of the genomics era. Expert Opinion On Drug Discovery. PMID 28277838 DOI: 10.1080/17460441.2017.1303478  0.498
2017 Yeo WL, Chew X, Smith DJ, Chan KP, Sun H, Zhao H, Lim YH, Ang EL. Probing the molecular determinants of fluorinase specificity. Chemical Communications (Cambridge, England). PMID 28184383 DOI: 10.1039/C6Cc09213F  0.446
2017 Liu Z, Liang Y, Ang EL, Zhao H. A New Era of Genome Integration - Simply Cut and Paste! Acs Synthetic Biology. PMID 28073246 DOI: 10.1021/Acssynbio.6B00331  0.443
2016 Sun H, Yeo WL, Lim YH, Chew X, Smith DJ, Xue B, Chan KP, Robinson RC, Robins EG, Zhao H, Ang EL. Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate. Angewandte Chemie (International Ed. in English). PMID 27739177 DOI: 10.1002/Anie.201606722  0.47
2016 Liang Y, Ang EL, Zhao H. A step through the looking glass. Science China. Life Sciences. PMID 27349997 DOI: 10.1007/S11427-016-0170-6  0.338
2016 Shi S, Si T, Liu Z, Zhang H, Ang EL, Zhao H. Metabolic engineering of a synergistic pathway for n-butanol production in Saccharomyces cerevisiae. Scientific Reports. 6: 25675. PMID 27161023 DOI: 10.1038/Srep25675  0.61
2016 Zhang MM, Wang Y, Ang EL, Zhao H. Engineering microbial hosts for production of bacterial natural products. Natural Product Reports. PMID 27072804 DOI: 10.1039/C6Np00017G  0.493
2016 Zhang H, Li X, Su X, Ang EL, Zhang Y, Zhao H. Production of Adipic Acid from Sugar Beet Residue by Combined Biological and Chemical Catalysis Chemcatchem. DOI: 10.1002/Cctc.201600069  0.436
2015 Sun H, Liu Z, Zhao H, Ang EL. Recent advances in combinatorial biosynthesis for drug discovery. Drug Design, Development and Therapy. 9: 823-33. PMID 25709407 DOI: 10.2147/Dddt.S63023  0.538
2014 Liang Y, Si T, Ang EL, Zhao H. Engineered pentafunctional minicellulosome for simultaneous saccharification and ethanol fermentation in Saccharomyces cerevisiae. Applied and Environmental Microbiology. 80: 6677-84. PMID 25149522 DOI: 10.1128/Aem.02070-14  0.608
2014 Liang Y, Ang EL, Zhao H. Directed evolution of enzymes for industrial biocatalysis Industrial Biocatalysis. 73-114.  0.398
2013 Zhang MM, Su X, Ang EL, Zhao H. Recent advances in biocatalyst development in the pharmaceutical industry Pharmaceutical Bioprocessing. 1: 179-196. DOI: 10.4155/Pbp.13.14  0.466
2009 Ang EL, Obbard JP, Zhao H. Directed evolution of aniline dioxygenase for enhanced bioremediation of aromatic amines. Applied Microbiology and Biotechnology. 81: 1063-70. PMID 18813921 DOI: 10.1007/S00253-008-1710-0  0.45
2007 Ang EL, Obbard JP, Zhao H. Probing the molecular determinants of aniline dioxygenase substrate specificity by saturation mutagenesis. The Febs Journal. 274: 928-39. PMID 17269935 DOI: 10.1111/J.1742-4658.2007.05638.X  0.496
2006 Lee JK, Ang EL, Zhao H. Probing the substrate specificity of aminopyrrolnitrin oxygenase (PrnD) by mutational analysis. Journal of Bacteriology. 188: 6179-83. PMID 16923884 DOI: 10.1128/Jb.00259-06  0.457
2005 Ang EL, Zhao H, Obbard JP. Recent advances in the bioremediation of persistent organic pollutants via biomolecular engineering Enzyme and Microbial Technology. 37: 487-496. DOI: 10.1016/J.Enzmictec.2004.07.024  0.513
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