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Thomas R. Cech - Publications

Chemistry and Biochemistry University of Colorado, Boulder, Boulder, CO, United States 
RNA (ribozyme) catalysis

251 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang X, Long Y, Paucek RD, Gooding AR, Lee T, Burdorf RM, Cech TR. Regulation of histone methylation by automethylation of PRC2. Genes & Development. PMID 31488576 DOI: 10.1101/gad.328849.119  0.88
2019 Wang X, Goodrich KJ, Conlon EG, Gao J, Erbse AH, Manley JL, Cech TR. C9orf72 and Triplet Repeat Disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms. Rna (New York, N.Y.). PMID 31048495 DOI: 10.1261/rna.071191.119  0.84
2018 Greenwood J, Patel H, Cech TR, Cooper JP. Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA. Nucleic Acids Research. PMID 29992245 DOI: 10.1093/nar/gky605  1
2018 Shoffner GM, Wang R, Podell E, Cech TR, Guo F. In Crystallo Selection to Establish New RNA Crystal Contacts. Structure (London, England : 1993). PMID 29910185 DOI: 10.1016/j.str.2018.05.005  1
2018 Youmans DT, Schmidt JC, Cech TR. Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits. Genes & Development. PMID 29891558 DOI: 10.1101/gad.311936.118  0.44
2018 Schmidt JC, Zaug AJ, Kufer R, Cech TR. Dynamics of human telomerase recruitment depend on template- telomere base pairing. Molecular Biology of the Cell. PMID 29386295 DOI: 10.1091/mbc.E17-11-0637  0.72
2017 Long Y, Bolanos B, Gong L, Liu W, Goodrich KJ, Yang X, Chen S, Gooding AR, Maegley KA, Gajiwala KS, Brooun A, Cech TR, Liu X. Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2. Elife. 6. PMID 29185984 DOI: 10.7554/eLife.31558  0.88
2017 Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nature Structural & Molecular Biology. PMID 29058709 DOI: 10.1038/nsmb.3487  0.88
2017 Lim CJ, Zaug AJ, Kim HJ, Cech TR. Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity. Nature Communications. 8: 1075. PMID 29057866 DOI: 10.1038/s41467-017-01313-w  0.72
2017 Long Y, Wang X, Youmans DT, Cech TR. How do lncRNAs regulate transcription? Science Advances. 3: eaao2110. PMID 28959731 DOI: 10.1126/sciadv.aao2110  0.64
2017 Wang X, Goodrich KJ, Gooding AR, Naeem H, Archer S, Paucek RD, Youmans DT, Cech TR, Davidovich C. Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines. Molecular Cell. 65: 1056-1067.e5. PMID 28306504 DOI: 10.1016/j.molcel.2017.02.003  0.88
2016 Schmidt JC, Zaug AJ, Cech TR. Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres. Cell. PMID 27523609 DOI: 10.1016/j.cell.2016.07.033  0.72
2016 Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY. RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure. Cell. PMID 27180905 DOI: 10.1016/j.cell.2016.04.028  1
2016 Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R. Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Nature Structural & Molecular Biology. PMID 26950371 DOI: 10.1038/nsmb.3184  1
2015 Xi L, Cech TR. Protein-RNA interaction restricts telomerase from running through the stop sign. Nature Structural & Molecular Biology. 22: 835-6. PMID 26581514 DOI: 10.1038/nsmb.3118  1
2015 Davidovich C, Cech TR. The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2. Rna (New York, N.Y.). 21: 2007-22. PMID 26574518 DOI: 10.1261/rna.053918.115  1
2015 Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR. A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression. Genome Biology. 16: 231. PMID 26553065 DOI: 10.1186/s13059-015-0791-1  1
2015 Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N, Cech TR. Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers. Genes & Development. 29: 2219-24. PMID 26515115 DOI: 10.1101/gad.269498.115  1
2015 Wang X, Schwartz JC, Cech TR. Nucleic acid-binding specificity of human FUS protein. Nucleic Acids Research. 43: 7535-43. PMID 26150427 DOI: 10.1093/nar/gkv679  1
2015 Schmidt JC, Cech TR. Human telomerase: biogenesis, trafficking, recruitment, and activation. Genes & Development. 29: 1095-1105. PMID 26063571 DOI: 10.1101/gad.263863.115  1
2015 Cech TR. RNA World research-still evolving. Rna (New York, N.Y.). 21: 474-5. PMID 25780099 DOI: 10.1261/rna.049965.115  1
2015 Borah S, Xi L, Zaug AJ, Powell NM, Dancik GM, Cohen SB, Costello JC, Theodorescu D, Cech TR. Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer. Science (New York, N.Y.). 347: 1006-10. PMID 25722414 DOI: 10.1126/science.1260200  1
2015 Dalby AB, Hofr C, Cech TR. Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase. Journal of Molecular Biology. 427: 1291-303. PMID 25623306 DOI: 10.1016/j.jmb.2015.01.008  1
2015 Davidovich C, Wang X, Cifuentes-Rojas C, Goodrich KJ, Gooding AR, Lee JT, Cech TR. Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. Molecular Cell. 57: 552-8. PMID 25601759 DOI: 10.1016/j.molcel.2014.12.017  1
2015 Schwartz JC, Cech TR, Parker RR. Biochemical Properties and Biological Functions of FET Proteins. Annual Review of Biochemistry. 84: 355-79. PMID 25494299 DOI: 10.1146/annurev-biochem-060614-034325  1
2015 Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, Zaug AJ, Liu D, Zhao Y, Cech TR, Ma W, Songyang Z. Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. Journal of Cell Science. 128: 331-41. PMID 25416818 DOI: 10.1242/jcs.159467  1
2014 Schmidt JC, Dalby AB, Cech TR. Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife. 3. PMID 25271372 DOI: 10.7554/eLife.03563  1
2014 Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR. FUS is sequestered in nuclear aggregates in ALS patient fibroblasts. Molecular Biology of the Cell. 25: 2571-8. PMID 25009283 DOI: 10.1091/mbc.E14-05-1007  1
2014 Davidovich C, Goodrich KJ, Gooding AR, Cech TR. A dimeric state for PRC2. Nucleic Acids Research. 42: 9236-48. PMID 24992961 DOI: 10.1093/nar/gku540  1
2014 Xi L, Cech TR. Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT. Nucleic Acids Research. 42: 8565-77. PMID 24990373 DOI: 10.1093/nar/gku560  1
2014 Cech TR, Steitz JA. The noncoding RNA revolution-trashing old rules to forge new ones. Cell. 157: 77-94. PMID 24679528 DOI: 10.1016/j.cell.2014.03.008  1
2014 McKay DB, Xi L, Barthel KK, Cech TR. Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA. Journal of Molecular Biology. 426: 1766-85. PMID 24486609 DOI: 10.1016/j.jmb.2014.01.006  1
2014 Theodorescu D, Cech TR. Telomerase in bladder cancer: back to a better future? European Urology. 65: 370-1. PMID 24184027 DOI: 10.1016/j.eururo.2013.10.019  1
2013 Schwartz JC, Wang X, Podell ER, Cech TR. RNA seeds higher-order assembly of FUS protein. Cell Reports. 5: 918-25. PMID 24268778 DOI: 10.1016/j.celrep.2013.11.017  1
2013 Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR. Inhibition of telomerase recruitment and cancer cell death. The Journal of Biological Chemistry. 288: 33171-80. PMID 24097987 DOI: 10.1074/jbc.M113.518175  1
2013 Davidovich C, Zheng L, Goodrich KJ, Cech TR. Promiscuous RNA binding by Polycomb repressive complex 2. Nature Structural & Molecular Biology. 20: 1250-7. PMID 24077223 DOI: 10.1038/nsmb.2679  1
2013 Goldfarb KC, Cech TR. 3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing. Bmc Molecular Biology. 14: 23. PMID 24053768 DOI: 10.1186/1471-2199-14-23  1
2013 Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR. Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Research. 41: 8969-78. PMID 23901009 DOI: 10.1093/nar/gkt653  1
2013 Dalby AB, Goodrich KJ, Pfingsten JS, Cech TR. RNA recognition by the DNA end-binding Ku heterodimer. Rna (New York, N.Y.). 19: 841-51. PMID 23610127 DOI: 10.1261/rna.038703.113  1
2013 Cech T, Steele F. The (noncoding) RNA world Nucleic Acid Therapeutics. 23: 1. PMID 23350901 DOI: 10.1089/nat.2013.1501  1
2013 Nandakumar J, Cech TR. Finding the end: recruitment of telomerase to telomeres. Nature Reviews. Molecular Cell Biology. 14: 69-82. PMID 23299958 DOI: 10.1038/nrm3505  1
2013 Cech TR. How a chemist looks at RNA. Angewandte Chemie (International Ed. in English). 52: 75-8. PMID 23203538 DOI: 10.1002/anie.201205427  1
2012 Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR. FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2. Genes & Development. 26: 2690-5. PMID 23249733 DOI: 10.1101/gad.204602.112  1
2012 Berman AJ, Cech TR. SnapShot: telomeres and telomerase. Cell. 151: 1138-1138.e1. PMID 23178129 DOI: 10.1016/j.cell.2012.11.008  1
2012 Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 492: 285-9. PMID 23103865 DOI: 10.1038/nature11648  1
2012 Goldfarb KC, Borah S, Cech TR. RNase P branches out from RNP to protein: organelle-triggered diversification? Genes & Development. 26: 1005-9. PMID 22588715 DOI: 10.1101/gad.193581.112  1
2012 Pfingsten JS, Goodrich KJ, Taabazuing C, Ouenzar F, Chartrand P, Cech TR. Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell. 148: 922-32. PMID 22365814 DOI: 10.1016/j.cell.2012.01.033  1
2012 Nandakumar J, Cech TR. DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Research. 40: 235-44. PMID 21911358 DOI: 10.1093/nar/gkr721  1
2012 Cech TR. The RNA worlds in context. Cold Spring Harbor Perspectives in Biology. 4: a006742. PMID 21441585 DOI: 10.1101/cshperspect.a006742  1
2011 Berman AJ, Akiyama BM, Stone MD, Cech TR. The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis. Nature Structural & Molecular Biology. 18: 1371-5. PMID 22101935 DOI: 10.1038/nsmb.2174  1
2011 Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, et al. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature. 474: 399-402. PMID 21602826 DOI: 10.1038/nature10084  1
2011 Taylor DJ, Podell ER, Taatjes DJ, Cech TR. Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. Journal of Molecular Biology. 410: 10-7. PMID 21596049 DOI: 10.1016/j.jmb.2011.04.049  1
2011 Zappulla DC, Goodrich KJ, Arthur JR, Gurski LA, Denham EM, Stellwagen AE, Cech TR. Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP. Rna (New York, N.Y.). 17: 298-311. PMID 21177376 DOI: 10.1261/rna.2483611  1
2010 Berman AJ, Gooding AR, Cech TR. Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants. Molecular and Cellular Biology. 30: 4965-76. PMID 20713447 DOI: 10.1128/MCB.00827-10  1
2010 Zaug AJ, Podell ER, Nandakumar J, Cech TR. Functional interaction between telomere protein TPP1 and telomerase. Genes & Development. 24: 613-22. PMID 20231318 DOI: 10.1101/gad.1881810  1
2010 Qiao F, Goodrich KJ, Cech TR. Engineering cis-telomerase RNAs that add telomeric repeats to themselves. Proceedings of the National Academy of Sciences of the United States of America. 107: 4914-8. PMID 20194781 DOI: 10.1073/pnas.0909366107  1
2010 Latrick CM, Cech TR. POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. The Embo Journal. 29: 924-33. PMID 20094033 DOI: 10.1038/emboj.2009.409  1
2010 Nandakumar J, Podell ER, Cech TR. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proceedings of the National Academy of Sciences of the United States of America. 107: 651-6. PMID 20080730 DOI: 10.1073/pnas.0911099107  1
2009 Cech TR. Evolution of biological catalysis: ribozyme to RNP enzyme. Cold Spring Harbor Symposia On Quantitative Biology. 74: 11-6. PMID 19850851 DOI: 10.1101/sqb.2009.74.024  1
2009 Andrews N, Burris JE, Cech TR, Coller BS, Crowley WF, Gallin EK, Kelner KL, Kirch DG, Leshner AI, Morris CD, Nguyen FT, Oates J, Sung NS. Translational careers. Science (New York, N.Y.). 324: 855. PMID 19443750 DOI: 10.1126/science.1172137  1
2009 Cech TR. Crawling out of the RNA world. Cell. 136: 599-602. PMID 19239881 DOI: 10.1016/j.cell.2009.02.002  1
2009 Vicens Q, Cech TR. A natural ribozyme with 3',5' RNA ligase activity. Nature Chemical Biology. 5: 97-9. PMID 19125157 DOI: 10.1038/nchembio.136  1
2009 Zappulla DC, Roberts JN, Goodrich KJ, Cech TR, Wuttke DS. Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p. Nucleic Acids Research. 37: 354-67. PMID 19043074 DOI: 10.1093/nar/gkn830  1
2008 Vicens Q, Paukstelis PJ, Westhof E, Lambowitz AM, Cech TR. Toward predicting self-splicing and protein-facilitated splicing of group I introns. Rna (New York, N.Y.). 14: 2013-29. PMID 18768647 DOI: 10.1261/rna.1027208  1
2008 Zaug AJ, Podell ER, Cech TR. Mutation in TERT separates processivity from anchor-site function. Nature Structural & Molecular Biology. 15: 870-2. PMID 18641663 DOI: 10.1038/nsmb.1462  1
2008 Qiao F, Cech TR. Triple-helix structure in telomerase RNA contributes to catalysis. Nature Structural & Molecular Biology. 15: 634-40. PMID 18500353 DOI: 10.1038/nsmb.1420  1
2008 Mozdy AD, Podell ER, Cech TR. Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance. Molecular and Cellular Biology. 28: 4152-61. PMID 18411302 DOI: 10.1128/MCB.00512-08  1
2007 Cech T, Dixon J, Meehan A, Briggs J, Rhodes C. A reply from HHMI Journal of Experimental Medicine. 204: 1731. PMID 17646402 DOI: 10.1084/jem.20071366  1
2007 Cech T, Dixon J, Meehan A, Briggs J, Rhodes C. A reply from Howard Hughes Medical Institute (HHMI) The Journal of Cell Biology. 178: 343; discussion 343. PMID 17646394  1
2007 Cech TR. On the occasion of the 25th anniversary of the discovery of catalytic RNA. Biological Chemistry. 388: 661-2. PMID 17570816 DOI: 10.1515/BC.2007.084  1
2007 Vicens Q, Gooding AR, Laederach A, Cech TR. Local RNA structural changes induced by crystallization are revealed by SHAPE. Rna (New York, N.Y.). 13: 536-48. PMID 17299128 DOI: 10.1261/rna.400207  1
2007 Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature. 445: 506-10. PMID 17237768 DOI: 10.1038/nature05454  1
2006 Zappulla DC, Cech TR. RNA as a flexible scaffold for proteins: yeast telomerase and beyond. Cold Spring Harbor Symposia On Quantitative Biology. 71: 217-24. PMID 17381300 DOI: 10.1101/sqb.2006.71.011  1
2006 Mozdy AD, Cech TR. Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency. Rna (New York, N.Y.). 12: 1721-37. PMID 16894218 DOI: 10.1261/rna.134706  1
2006 Jacobs SA, Podell ER, Cech TR. Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nature Structural & Molecular Biology. 13: 218-25. PMID 16462747 DOI: 10.1038/nsmb1054  1
2006 Guo F, Gooding AR, Cech TR. Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. Rna (New York, N.Y.). 12: 387-95. PMID 16431981 DOI: 10.1261/rna.2198206  1
2006 Vicens Q, Cech TR. Atomic level architecture of group I introns revealed. Trends in Biochemical Sciences. 31: 41-51. PMID 16356725 DOI: 10.1016/j.tibs.2005.11.008  1
2005 Cech T. Meeting a fork in the road: an interview with Tom Cech. Interview by Jane Gitschier Plos Genetics. 1: e76. PMID 16758005 DOI: 10.1371/journal.pgen.0010076  1
2005 Cech T, Kennedy D. Doing more for Kate. Science (New York, N.Y.). 310: 1741. PMID 16357228 DOI: 10.1126/science.1123580  1
2005 Zappulla DC, Goodrich K, Cech TR. A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro. Nature Structural & Molecular Biology. 12: 1072-7. PMID 16299517 DOI: 10.1038/nsmb1019  1
2005 Cech TR. Fostering innovation and discovery in biomedical research. Jama. 294: 1390-3. PMID 16174699 DOI: 10.1001/jama.294.11.1390  1
2005 Jacobs SA, Podell ER, Wuttke DS, Cech TR. Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Science : a Publication of the Protein Society. 14: 2051-8. PMID 16046627 DOI: 10.1110/ps.051532105  1
2005 Zaug AJ, Podell ER, Cech TR. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proceedings of the National Academy of Sciences of the United States of America. 102: 10864-9. PMID 16043710 DOI: 10.1073/pnas.0504744102  1
2005 Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. The Journal of Biological Chemistry. 280: 32069-80. PMID 16030011 DOI: 10.1074/jbc.M505211200  1
2005 Lei M, Zaug AJ, Podell ER, Cech TR. Switching human telomerase on and off with hPOT1 protein in vitro. The Journal of Biological Chemistry. 280: 20449-56. PMID 15792951 DOI: 10.1074/jbc.M502212200  1
2005 Mandell JG, Bähler J, Volpe TA, Martienssen RA, Cech TR. Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biology. 6: R1. PMID 15642092 DOI: 10.1186/gb-2004-6-1-r1  1
2005 Mandell JG, Goodrich KJ, Bähler J, Cech TR. Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. The Journal of Biological Chemistry. 280: 5249-57. PMID 15591066 DOI: 10.1074/jbc.M412756200  1
2004 Cech TR. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Bioscience Reports. 24: 362-85. PMID 16134019 DOI: 10.1007/s10540-005-2738-3  1
2004 Cech TR, Rubin GM. Nurturing interdisciplinary research. Nature Structural & Molecular Biology. 11: 1166-9. PMID 15578058 DOI: 10.1038/nsmb1204-1166  1
2004 Lei M, Podell ER, Cech TR. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nature Structural & Molecular Biology. 11: 1223-9. PMID 15558049 DOI: 10.1038/nsmb867  1
2004 Guo F, Gooding AR, Cech TR. Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Molecular Cell. 16: 351-62. PMID 15525509 DOI: 10.1016/j.molcel.2004.10.003  1
2004 Zappulla DC, Cech TR. Yeast telomerase RNA: a flexible scaffold for protein subunits. Proceedings of the National Academy of Sciences of the United States of America. 101: 10024-9. PMID 15226497 DOI: 10.1073/pnas.0403641101  1
2004 Aigner S, Cech TR. The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. Rna (New York, N.Y.). 10: 1108-18. PMID 15208446 DOI: 10.1261/rna.7400704  1
2004 Cech TR, Bond E. Managing your own lab. Science (New York, N.Y.). 304: 1717. PMID 15205494 DOI: 10.1126/science.304.5678.1717  1
2004 Cech TR. RNA finds a simpler way. Nature. 428: 263-4. PMID 15029175 DOI: 10.1038/428263a  1
2004 Cech TR. Beginning to understand the end of the chromosome. Cell. 116: 273-9. PMID 14744437 DOI: 10.1002/9783527620982.ch1  1
2003 Lei M, Podell ER, Baumann P, Cech TR. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature. 426: 198-203. PMID 14614509 DOI: 10.1038/nature02092  1
2003 Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR. A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. Rna (New York, N.Y.). 9: 1323-32. PMID 14561882  0.72
2003 Bryan TM, Goodrich KJ, Cech TR. Tetrahymena telomerase is active as a monomer. Molecular Biology of the Cell. 14: 4794-804. PMID 13679509 DOI: 10.1091/mbc.E03-07-0474  1
2003 Classen S, Lyons D, Cech TR, Schultz SC. Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit. Biochemistry. 42: 9269-77. PMID 12899613 DOI: 10.1021/bi0273718  1
2003 Colgin LM, Baran K, Baumann P, Cech TR, Reddel RR. Human POT1 facilitates telomere elongation by telomerase. Current Biology : Cb. 13: 942-6. PMID 12781132 DOI: 10.1016/S0960-9822(03)00339-7  1
2003 Roccanova L, Cech TR. Inoculating a science education epidemic [4] (multiple letters) Science. 300: 1236. PMID 12764176  1
2003 Cech TR, Eddy SR, Eisenberg D, Hersey K, Holtzman SH, Poste GH, Raikhel NV, Scheller RH, Singer DB, Waltham MC. Sharing publication-related data and materials: responsibilities of authorship in the life sciences. Plant Physiology. 132: 19-24. PMID 12746507 DOI: 10.1104/pp.900068  1
2003 Aigner S, Postberg J, Lipps HJ, Cech TR. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry. 42: 5736-47. PMID 12741831 DOI: 10.1021/bi034121y  1
2003 Förstemann K, Zaug AJ, Cech TR, Lingner J. Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Research. 31: 1646-55. PMID 12626706 DOI: 10.1093/nar/gkg261  1
2003 Friedman KL, Heit JJ, Long DM, Cech TR. N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex. Molecular Biology of the Cell. 14: 1-13. PMID 12529422 DOI: 10.1091/mbc.E02-06-0327  1
2003 Cech TR. Rebalancing teaching and research. Science (New York, N.Y.). 299: 165. PMID 12522218 DOI: 10.1126/science.299.5604.165  1
2002 Lei M, Baumann P, Cech TR. Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry. 41: 14560-8. PMID 12463756 DOI: 10.1021/bi026674z  1
2002 Cech TR. Ribozymes, the first 20 years. Biochemical Society Transactions. 30: 1162-6. PMID 12440996 DOI: 10.1042/  1
2002 Seto AG, Livengood AJ, Tzfati Y, Blackburn EH, Cech TR. A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes & Development. 16: 2800-12. PMID 12414733 DOI: 10.1101/gad.1029302  0.72
2002 Baumann P, Podell E, Cech TR. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Molecular and Cellular Biology. 22: 8079-87. PMID 12391173 DOI: 10.1128/MCB.22.22.8079-8087.2002  1
2002 Guo F, Cech TR. Evolution of Tetrahymena ribozyme mutants with increased structural stability. Nature Structural Biology. 9: 855-61. PMID 12368901 DOI: 10.1038/nsb850  1
2002 Doudna JA, Cech TR. The chemical repertoire of natural ribozymes. Nature. 418: 222-8. PMID 12110898 DOI: 10.1038/418222a  0.96
2002 Guo F, Cech TR. In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron. Rna (New York, N.Y.). 8: 647-58. PMID 12022231 DOI: 10.1017/S1355838202029011  1
2002 Livengood AJ, Zaug AJ, Cech TR. Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Molecular and Cellular Biology. 22: 2366-74. PMID 11884619 DOI: 10.1128/MCB.22.7.2366-2374.2002  1
2002 Cech TR. HHMI's attention to Wiley's lab staff. Science (New York, N.Y.). 295: 43. PMID 11780644  1
2002 Jarstfer MB, Cech TR. Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation. Biochemistry. 41: 151-61. PMID 11772012 DOI: 10.1021/bi011649z  1
2001 Cohen SB, Cech TR. Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 5.1. PMID 18428857 DOI: 10.1002/0471142700.nc0501s00  1
2001 Cech TR, Egan LW, Doyle C, Gallin E, Lichtman MA, Queenan CJ, Sung N. The biomedical research bottleneck. Science (New York, N.Y.). 293: 573. PMID 11474070 DOI: 10.1126/science.293.5530.573  1
2001 Sperger JM, Cech TR. A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity. Biochemistry. 40: 7005-16. PMID 11401544  1
2001 Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (New York, N.Y.). 292: 1171-5. PMID 11349150 DOI: 10.1126/science.1060036  1
2001 Juneau K, Podell E, Harrington DJ, Cech TR. Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions. Structure (London, England : 1993). 9: 221-31. PMID 11286889 DOI: 10.1016/S0969-2126(01)00579-2  1
2001 Silverman SK, Cech TR. An early transition state for folding of the P4-P6 RNA domain. Rna (New York, N.Y.). 7: 161-6. PMID 11233973 DOI: 10.1017/S1355838201001716  1
2001 Cech TR, Leonard JS. Science and business. Conflicts of interest--moving beyond disclosure. Science (New York, N.Y.). 291: 989. PMID 11232584 DOI: 10.1126/science.291.5506.989  1
2000 Aigner S, Lingner J, Goodrich KJ, Grosshans CA, Shevchenko A, Mann M, Cech TR. Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting. The Embo Journal. 19: 6230-9. PMID 11080168 DOI: 10.1093/emboj/19.22.6230  1
2000 Baumann P, Cech TR. Protection of telomeres by the Ku protein in fission yeast. Molecular Biology of the Cell. 11: 3265-75. PMID 11029034  1
2000 Silverman SK, Deras ML, Woodson SA, Scaringe SA, Cech TR. Multiple folding pathways for the P4-P6 RNA domain. Biochemistry. 39: 12465-75. PMID 11015228 DOI: 10.1021/bi000828y  1
2000 Bryan TM, Goodrich KJ, Cech TR. Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Molecular Cell. 6: 493-9. PMID 10983995  1
2000 Cech TR. Structural biology. The ribosome is a ribozyme. Science (New York, N.Y.). 289: 878-9. PMID 10960319 DOI: 10.1126/science.289.5481.878  1
2000 Haering CH, Nakamura TM, Baumann P, Cech TR. Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe. Proceedings of the National Academy of Sciences of the United States of America. 97: 6367-72. PMID 10829083 DOI: 10.1073/pnas.130187397  1
2000 Bryan TM, Goodrich KJ, Cech TR. A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. The Journal of Biological Chemistry. 275: 24199-207. PMID 10807925 DOI: 10.1074/jbc.M003246200  1
2000 Cech TR. Life at the End of the Chromosome: Telomeres and Telomerase. Angewandte Chemie (International Ed. in English). 39: 34-43. PMID 10649348 DOI: 10.1002/(SICI)1521-3773(20000103)39:1<34::AID-ANIE34>3.0.CO;2-N  1
1999 Silverman SK, Zheng M, Wu M, Tinoco I, Cech TR. Quantifying the energetic interplay of RNA tertiary and secondary structure interactions. Rna (New York, N.Y.). 5: 1665-74. PMID 10606276 DOI: 10.1017/S1355838299991823  1
1999 Silverman SK, Cech TR. RNA tertiary folding monitored by fluorescence of covalently attached pyrene. Biochemistry. 38: 14224-37. PMID 10571996 DOI: 10.1021/bi991333f  1
1999 Hagen M, Cech TR. Self-splicing of the Tetrahymena intron from mRNA in mammalian cells. The Embo Journal. 18: 6491-500. PMID 10562561 DOI: 10.1093/emboj/18.22.6491  1
1999 Friedman KL, Cech TR. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes & Development. 13: 2863-74. PMID 10557213 DOI: 10.1101/gad.13.21.2863  1
1999 Seto AG, Zaug AJ, Sobel SG, Wolin SL, Cech TR. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature. 401: 177-80. PMID 10490028 DOI: 10.1038/43694  1
1999 Juneau K, Cech TR. In vitro selection of RNAs with increased tertiary structure stability. Rna (New York, N.Y.). 5: 1119-29. PMID 10445885 DOI: 10.1017/S135583829999074X  1
1999 Bryan TM, Cech TR. Telomerase and the maintenance of chromosome ends. Current Opinion in Cell Biology. 11: 318-24. PMID 10395557 DOI: 10.1016/S0955-0674(99)80043-X  1
1999 Silverman SK, Cech TR. Energetics and cooperativity of tertiary hydrogen bonds in RNA structure. Biochemistry. 38: 8691-702. PMID 10393544 DOI: 10.1021/bi9906118  1
1999 Cech TR. Science at liberal arts colleges: A better education? Daedalus. 128: 195-216.  1
1998 Jabri E, Cech TR. In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity. Rna (New York, N.Y.). 4: 1481-92. PMID 9848647 DOI: 10.1017/S1355838298981237  1
1998 Golden BL, Gooding AR, Podell ER, Cech TR. A preorganized active site in the crystal structure of the Tetrahymena ribozyme. Science (New York, N.Y.). 282: 259-64. PMID 9841391 DOI: 10.1126/science.282.5387.259  1
1998 Zhang B, Cech TR. Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features. Chemistry & Biology. 5: 539-53. PMID 9818147  1
1998 Nakamura TM, Cooper JP, Cech TR. Two modes of survival of fission yeast without telomerase. Science (New York, N.Y.). 282: 493-6. PMID 9774280 DOI: 10.1126/science.282.5388.493  1
1998 Cohen SB, Cech TR. A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps. Rna (New York, N.Y.). 4: 1179-85. PMID 9769093 DOI: 10.1017/S1355838298001010  1
1998 Szewczak AA, Podell ER, Bevilacqua PC, Cech TR. Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis. Biochemistry. 37: 11162-70. PMID 9698362 DOI: 10.1021/bi980633e  1
1998 Bryan TM, Sperger JM, Chapman KB, Cech TR. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proceedings of the National Academy of Sciences of the United States of America. 95: 8479-84. PMID 9671703 DOI: 10.1073/pnas.95.15.8479  1
1998 Lingner J, Cech TR. Telomerase and chromosome end maintenance. Current Opinion in Genetics & Development. 8: 226-32. PMID 9610414 DOI: 10.1016/S0959-437X(98)80145-7  1
1998 Froelich-Ammon SJ, Dickinson BA, Bevilacqua JM, Schultz SC, Cech TR. Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha. Genes & Development. 12: 1504-14. PMID 9585510  1
1998 Bevilacqua PC, George CX, Samuel CE, Cech TR. Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes. Biochemistry. 37: 6303-16. PMID 9572845 DOI: 10.1021/bi980113j  1
1998 Hammond PW, Cech TR. Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation. Biochemistry. 37: 5162-72. PMID 9548747 DOI: 10.1021/bi972988o  1
1998 Nakamura TM, Cech TR. Reversing time: origin of telomerase. Cell. 92: 587-90. PMID 9506510 DOI: 10.1016/S0092-8674(00)81123-X  1
1997 Cech TR, Lingner J. Telomerase and the chromosome end replication problem. Ciba Foundation Symposium. 211: 20-8; discussion 28-. PMID 9524749  1
1997 Cech TR, Nakamura TM, Lingner J. Telomerase is a true reverse transcriptase. A review. Biochemistry. Biokhimii͡A. 62: 1202-5. PMID 9467843  1
1997 Chapon C, Cech TR, Zaug AJ. Polyadenylation of telomerase RNA in budding yeast. Rna (New York, N.Y.). 3: 1337-51. PMID 9409624  1
1997 Jabri E, Aigner S, Cech TR. Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis. Biochemistry. 36: 16345-54. PMID 9405070 DOI: 10.1021/bi9718595  1
1997 Zhang B, Cech TR. Peptide bond formation by in vitro selected ribozymes. Nature. 390: 96-100. PMID 9363898 DOI: 10.1038/36375  1
1997 Lingner J, Cech TR, Hughes TR, Lundblad V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proceedings of the National Academy of Sciences of the United States of America. 94: 11190-5. PMID 9326584 DOI: 10.1073/pnas.94.21.11190  1
1997 Tanner MA, Anderson EM, Gutell RR, Cech TR. Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. Rna (New York, N.Y.). 3: 1037-51. PMID 9292502  1
1997 Weinstein LB, Jones BC, Cosstick R, Cech TR. A second catalytic metal ion in group I ribozyme. Nature. 388: 805-8. PMID 9285596 DOI: 10.1038/42076  1
1997 Hammond PW, Cech TR. dGTP-dependent processivity and possible template switching of euplotes telomerase. Nucleic Acids Research. 25: 3698-704. PMID 9278493 DOI: 10.1093/nar/25.18.3698  1
1997 Szewczak AA, Cech TR. An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis. Rna (New York, N.Y.). 3: 838-49. PMID 9257643  1
1997 Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science (New York, N.Y.). 277: 955-9. PMID 9252327 DOI: 10.1126/science.277.5328.955  1
1997 Golden BL, Podell ER, Gooding AR, Cech TR. Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron. Journal of Molecular Biology. 270: 711-23. PMID 9245599 DOI: 10.1006/jmbi.1997.1155  1
1997 McConnell TS, Herschlag D, Cech TR. Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction. Biochemistry. 36: 8293-303. PMID 9204875 DOI: 10.1021/bi9700678  1
1997 Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science (New York, N.Y.). 276: 561-7. PMID 9110970 DOI: 10.1126/science.276.5312.561  1
1997 Cooper JP, Nimmo ER, Allshire RC, Cech TR. Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature. 385: 744-7. PMID 9034194 DOI: 10.1038/385744a0  1
1997 Tanner MA, Cech TR. Joining the two domains of a group I ribozyme to form the catalytic core. Science (New York, N.Y.). 275: 847-9. PMID 9012355 DOI: 10.1126/science.275.5301.847  1
1997 Hammond PW, Lively TN, Cech TR. The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers. Molecular and Cellular Biology. 17: 296-308. PMID 8972210  1
1997 Cohen SB, Cech TR. Dynamics of thermal motions within a large catalytic RNA investigated by cross-linking with thiol-disulfide interchange Journal of the American Chemical Society. 119: 6259-6268. DOI: 10.1021/ja9707421  1
1996 Golden BL, Gooding AR, Podell ER, Cech TR. X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering. Rna (New York, N.Y.). 2: 1295-305. PMID 8972777  1
1996 Rusconi CP, Cech TR. The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena. Genes & Development. 10: 2870-80. PMID 8918888  1
1996 Kuo LY, Cech TR. Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes. Nucleic Acids Research. 24: 3722-7. PMID 8871550 DOI: 10.1093/nar/24.19.3722  1
1996 Lingner J, Cech TR. Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang. Proceedings of the National Academy of Sciences of the United States of America. 93: 10712-7. PMID 8855245  1
1996 Tanner MA, Cech TR. Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(Ile) of the purple bacterium Azoarcus Rna. 2: 74-83. PMID 8846298  1
1996 Campbell TB, Cech TR. Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity. Biochemistry. 35: 11493-502. PMID 8784205 DOI: 10.1021/bi960510z  1
1996 Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Szewczak AA, Kundrot CE, Cech TR, Doudna JA. RNA tertiary structure mediation by adenosine platforms. Science (New York, N.Y.). 273: 1696-9. PMID 8781229  1
1996 Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA. Crystal structure of a group I ribozyme domain: principles of RNA packing. Science (New York, N.Y.). 273: 1678-85. PMID 8781224  1
1996 Bevilacqua PC, Cech TR. Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR. Biochemistry. 35: 9983-94. PMID 8756460 DOI: 10.1021/bi9607259  1
1996 Downs WD, Cech TR. Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks. Rna (New York, N.Y.). 2: 718-32. PMID 8756414  1
1996 Cech TR, Szewczak AA. Selecting apt RNAs for NMR. Rna (New York, N.Y.). 2: 625-7. PMID 8756405  1
1996 Rusconi CP, Cech TR. Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila. The Embo Journal. 15: 3286-95. PMID 8670829  1
1996 Golden BL, Cech TR. Conformational switches involved in orchestrating the successive steps of group I RNA splicing. Biochemistry. 35: 3754-63. PMID 8619996 DOI: 10.1021/bi952599z  1
1996 Zaug AJ, Linger J, Cech TR. Method for determining RNA 3' ends and application to human telomerase RNA. Nucleic Acids Research. 24: 532-3. PMID 8602368  1
1996 Strobel SA, Cech TR. Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization. Biochemistry. 35: 1201-11. PMID 8573575 DOI: 10.1021/bi952244f  1
1996 Weeks KM, Cech TR. Assembly of a ribonucleoprotein catalyst by tertiary structure capture. Science (New York, N.Y.). 271: 345-8. PMID 8553068  1
1996 Weinstein LB, Earnshaw DJ, Cosstick R, Cech TR. Synthesis and characterization of an RNA dinucleotide containing a 3'-S-phosphorothiolate linkage Journal of the American Chemical Society. 118: 10341-10350. DOI: 10.1021/ja9616903  1
1995 Vermeij GJ. Through the glass lightly. Science (New York, N.Y.). 267: 1617. PMID 17808170 DOI: 10.1126/science.267.5204.1617-d  1
1995 Strobel SA, Cech TR. Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site. Science (New York, N.Y.). 267: 675-9. PMID 7839142  1
1995 McConnell TS, Cech TR. A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction. Biochemistry. 34: 4056-67. PMID 7696271 DOI: 10.1021/bi00012a024  1
1995 Weeks KM, Cech TR. Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain. Cell. 82: 221-30. PMID 7628013 DOI: 10.1016/0092-8674(95)90309-7  1
1995 Fang G, Cech TR. Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates. The Journal of Cell Biology. 130: 243-53. PMID 7615628 DOI: 10.1083/jcb.130.2.243  1
1995 Hicke B, Rempel R, Maller J, Swank RA, Hamaguchi JR, Bradbury EM, Prescott DM, Cech TR. Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation. Nucleic Acids Research. 23: 1887-93. PMID 7596814  1
1995 Nakamura TM, Wang YH, Zaug AJ, Griffith JD, Cech TR. Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy. The Embo Journal. 14: 4849-59. PMID 7588614  1
1995 Lingner J, Cooper JP, Cech TR. Telomerase and DNA end replication: no longer a lagging strand problem? Science (New York, N.Y.). 269: 1533-4. PMID 7545310  1
1995 Weeks KM, Cech TR. Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron. Biochemistry. 34: 7728-38. PMID 7540041  1
1995 Doudna JA, Cech TR, Sullenger BA. Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 92: 2355-9. PMID 7534420  0.96
1995 Zaug AJ, Cech TR. Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA. Rna (New York, N.Y.). 1: 363-74. PMID 7493315  1
1995 Tanner MA, Cech TR. An important RNA tertiary interaction of group I and group II introns is implicated in gram-positive RNase P RNAs. Rna (New York, N.Y.). 1: 349-50. PMID 7493313  1
1995 Campbell TB, Cech TR. Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA. Rna (New York, N.Y.). 1: 598-609. PMID 7489519  1
1995 Doudna JA, Cech TR. Self-assembly of a group I intron active site from its component tertiary structural domains. Rna (New York, N.Y.). 1: 36-45. PMID 7489486  0.96
1994 Hicke BJ, Willis MC, Koch TH, Cech TR. Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine Biochemistry. 33: 3364-3373. PMID 8136374  1
1994 Murphy FL, Wang YH, Griffith JD, Cech TR. Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme Science. 265: 1709-1712. PMID 8085157  1
1994 Cech TR, Uhlenbeck OC. Ribozymes. Hammerhead nailed down. Nature. 372: 39-40. PMID 7969416 DOI: 10.1038/372039a0  1
1994 Lingner J, Hendrick LL, Cech TR. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes & Development. 8: 1984-98. PMID 7958872  1
1994 Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR. Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity. Biochemistry. 33: 13856-63. PMID 7947794  1
1994 Cech TR. Chromosome end games Science. 266: 387-388. PMID 7939679  1
1994 Sullenger BA, Cech TR. Ribozyme-mediated repair of defective mRNA by targeted trans-splicing Nature. 371: 619-622. PMID 7935797 DOI: 10.1038/371619a0  1
1994 Strobel SA, Cech TR. Translocation of an RNA duplex on a ribozyme. Nature Structural Biology. 1: 13-7. PMID 7544680  1
1994 Zaug AJ, Dávila-Aponte JA, Cech TR. Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNALeu Biochemistry. 33: 14935-14947. PMID 7527660  1
1994 Strobel SA, Cech TR, Usman N, Beigelman L. The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA. Biochemistry. 33: 13824-35. PMID 7524665  1
1994 Strobel SA, Cech TR, Usman N, Beigelman L. The 2,6-diaminopurine riboside·5-methylisocytidine wobble base pair: An isoenergetic substitution for the study of G·U pairs in RNA Biochemistry. 33: 13824-13835. DOI: 10.1021/bi00250a037  1
1993 Piccirilli JA, Vyle JS, Caruthers MH, Cech TR. Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature. 361: 85-8. PMID 8421499 DOI: 10.1038/361085a0  1
1993 McConnell TS, Cech TR, Herschlag D. Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding. Proceedings of the National Academy of Sciences of the United States of America. 90: 8362-6. PMID 8378306  1
1993 Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR. Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Molecular and Cellular Biology. 13: 4301-10. PMID 8321232  1
1993 Herschlag D, Eckstein F, Cech TR. The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction. Biochemistry. 32: 8312-21. PMID 7688573  1
1993 Herschlag D, Eckstein F, Cech TR. Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA. Biochemistry. 32: 8299-311. PMID 7688572  1
1993 Strobel SA, Cech TR. Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme. Biochemistry. 32: 13593-604. PMID 7504953 DOI: 10.1021/bi00212a027  1
1992 Piccirilli JA, McConnell TS, Zaug AJ, Noller HF, Cech TR. Aminoacyl esterase activity of the Tetrahymena ribozyme. Science (New York, N.Y.). 256: 1420-4. PMID 1604316  1
1992 Legault P, Herschlag D, Celander DW, Cech TR. Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis. Nucleic Acids Research. 20: 6613-9. PMID 1480482 DOI: 10.1093/nar/20.24.6613  1
1992 Cech TR, Herschlag D, Piccirilli JA, Pyle AM. RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization. The Journal of Biological Chemistry. 267: 17479-82. PMID 1381347  1
1992 Pyle AM, Murphy FL, Cech TR. RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme. Nature. 358: 123-8. PMID 1377367 DOI: 10.1038/358123a0  1
1991 Herschlag D, Piccirilli JA, Cech TR. Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom. Biochemistry. 30: 4844-54. PMID 2036355  1
1991 Zahler AM, Williamson JR, Cech TR, Prescott DM. Inhibition of telomerase by G-quartet DNA structures. Nature. 350: 718-20. PMID 2023635 DOI: 10.1038/350718a0  1
1991 Woodson SA, Cech TR. Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA. Biochemistry. 30: 2042-50. PMID 1998665  1
1991 Young B, Herschlag D, Cech TR. Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity. Cell. 67: 1007-19. PMID 1959129  1
1991 Gray JT, Celander DW, Price CM, Cech TR. Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell. 67: 807-14. PMID 1840510  1
1991 Pyle AM, Cech TR. Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups. Nature. 350: 628-31. PMID 1708111 DOI: 10.1038/350628a0  1
1990 Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site. Biochemistry. 29: 10172-80. PMID 2271646  1
1990 Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site. Biochemistry. 29: 10159-71. PMID 2271645  1
1990 Pyle AM, McSwiggen JA, Cech TR. Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America. 87: 8187-91. PMID 2236030  1
1990 Herschlag D, Cech TR. DNA cleavage catalysed by the ribozyme from Tetrahymena. Nature. 344: 405-9. PMID 1690858 DOI: 10.1038/344405a0  1
1990 Hicke BJ, Celander DW, MacDonald GH, Price CM, Cech TR. Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova. Proceedings of the National Academy of Sciences of the United States of America. 87: 1481-5. PMID 1689486  1
1989 Price CM, Cech TR. Properties of the telomeric DNA-binding protein from Oxytricha nova. Biochemistry. 28: 769-74. PMID 2713343  1
1989 Woodson SA, Cech TR. Reverse self-splicing of the tetrahymena group I intron: implication for the directionality of splicing and for intron transposition. Cell. 57: 335-45. PMID 2702692 DOI: 10.1016/0092-8674(89)90971-9  1
1989 Williamson JR, Raghuraman MK, Cech TR. Monovalent cation-induced structure of telomeric DNA: the G-quartet model. Cell. 59: 871-80. PMID 2590943 DOI: 10.1016/0092-8674(89)90610-7  1
1987 Price CM, Cech TR. Telomeric DNA-protein interactions of Oxytricha macronuclear DNA. Genes & Development. 1: 783-93. PMID 3123321  1
1984 Gottschling DE, Cech TR. Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex. Cell. 38: 501-10. PMID 6432344 DOI: 10.1016/0092-8674(84)90505-1  1
1984 Pardue ML, Fostel JM, Cech TR. DNA-protein interactions in the Drosophila virilis mitochondrial chromosome. Nucleic Acids Research. 12: 1991-9. PMID 6322130 DOI: 10.1093/nar/12.4.1991  1
1983 Gottschling DE, Palen TE, Cech TR. Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila. Nucleic Acids Research. 11: 2093-109. PMID 6835846 DOI: 10.1093/nar/11.7.2093  1
1982 Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell. 31: 147-57. PMID 6297745 DOI: 10.1016/0092-8674(82)90414-7  1
1980 Potter DA, Fostel JM, Berninger M, Pardue ML, Cech TR. DNA-protein interactions in the Drosophila melanogaster mitochondrial genome as deduced from trimethylpsoralen crosslinking patterns. Proceedings of the National Academy of Sciences of the United States of America. 77: 4118-22. PMID 6776522 DOI: 10.1073/pnas.77.7.4118  1
1978 Cech TR, Potter D, Pardue ML. Chromatin structure in living cells. Cold Spring Harbor Symposia On Quantitative Biology. 42: 191-8. PMID 277339  1
1976 Cech TR, Pardue ML. Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences. Proceedings of the National Academy of Sciences of the United States of America. 73: 2644-8. PMID 1066674  1
1976 Wiesehahn G, Cech TR, Hearst JE. A study of DNA denaturation in the ultracentrifuge. Biopolymers. 15: 1591-613. PMID 822895 DOI: 10.1002/bip.1976.360150813  1
1976 Cech TR, Hearst JE. Organization of highly repeated sequences in mouse main-band DNA. Journal of Molecular Biology. 100: 227-56. PMID 768484  1
1976 Cech TR, Reisler F, Hearst JE. Partial denaturation of mouse DNA in preparative CsCl density gradients at alkaline pH. Biochemistry. 15: 1865-73. PMID 5117  1
1975 Cech TR, Hearst JE. An electron microscopic study of mouse foldback DNA. Cell. 5: 429-46. PMID 1157097  1
1974 Hearst JE, Cech TR, Marx KA, Rosenfeld A, Allen JR. Characterization of the rapidly renaturing sequences in the main CsCl density bands of Drosophila, mouse, and human DNA. Cold Spring Harbor Symposia On Quantitative Biology. 38: 329-39. PMID 4208786  1
1973 Cech TR, Rosenfeld A, Hearst JE. Characterization of the most rapidly renaturing sequences in mouse main-band DNA. Journal of Molecular Biology. 81: 299-325. PMID 4767458  1
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