| Year |
Citation |
Score |
| 2006 |
Onsum MD, Wong K, Herzmark P, Bourne HR, Arkin AP. Morphology matters in immune cell chemotaxis: membrane asymmetry affects amplification. Physical Biology. 3: 190-9. PMID 17021383 DOI: 10.1088/1478-3975/3/3/004 |
0.326 |
|
| 2006 |
Wong K, Pertz O, Hahn K, Bourne H. Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proceedings of the National Academy of Sciences of the United States of America. 103: 3639-44. PMID 16537448 DOI: 10.1073/Pnas.0600092103 |
0.342 |
|
| 2006 |
Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. Plos Biology. 4: e38. PMID 16417406 DOI: 10.1371/Journal.Pbio.0040038 |
0.718 |
|
| 2005 |
Bourne HR. Rac and cell migration: CDM proteins integrate signals. Nature Cell Biology. 7: 777-8. PMID 16056271 DOI: 10.1038/Ncb0805-777 |
0.364 |
|
| 2003 |
Yu W, O'Brien LE, Wang F, Bourne H, Mostov KE, Zegers MM. Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Molecular Biology of the Cell. 14: 748-63. PMID 12589067 DOI: 10.1091/Mbc.E02-06-0350 |
0.31 |
|
| 2003 |
Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, Aktories K, Kalman D, Bourne HR. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. The Journal of Cell Biology. 160: 375-85. PMID 12551955 DOI: 10.1083/Jcb.200208179 |
0.343 |
|
| 2002 |
Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, et al. Overview of the Alliance for Cellular Signaling. Nature. 420: 703-6. PMID 12478301 DOI: 10.1038/Nature01304 |
0.435 |
|
| 2002 |
Bourne HR, Weiner O. A chemical compass. Nature. 419: 21. PMID 12214215 DOI: 10.1038/419021A |
0.598 |
|
| 2002 |
Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nature Cell Biology. 4: 509-13. PMID 12080346 DOI: 10.1038/Ncb811 |
0.706 |
|
| 2002 |
Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, Bourne HR. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nature Cell Biology. 4: 513-8. PMID 12080345 DOI: 10.1038/Ncb810 |
0.626 |
|
| 2001 |
Meng EC, Bourne HR. Receptor activation: what does the rhodopsin structure tell us? Trends in Pharmacological Sciences. 22: 587-93. PMID 11698103 DOI: 10.1016/S0165-6147(00)01825-3 |
0.33 |
|
| 2001 |
Rondard P, Iiri T, Srinivasan S, Meng E, Fujita T, Bourne HR. Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation? Proceedings of the National Academy of Sciences of the United States of America. 98: 6150-5. PMID 11344266 DOI: 10.1073/Pnas.101136198 |
0.437 |
|
| 2000 |
Rickert P, Weiner OD, Wang F, Bourne HR, Servant G. Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends in Cell Biology. 10: 466-73. PMID 11050418 DOI: 10.1016/S0962-8924(00)01841-9 |
0.63 |
|
| 2000 |
Bourne HR, Meng EC. Structure. Rhodopsin sees the light. Science (New York, N.Y.). 289: 733-4. PMID 10950717 DOI: 10.1126/Science.289.5480.733 |
0.345 |
|
| 2000 |
Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, Bourne HR. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (New York, N.Y.). 287: 1037-40. PMID 10669415 DOI: 10.1126/Science.287.5455.1037 |
0.73 |
|
| 2000 |
Fishburn CS, Pollitt SK, Bourne HR. Localization of a peripheral membrane protein: Gbetagamma targets Galpha(Z). Proceedings of the National Academy of Sciences of the United States of America. 97: 1085-90. PMID 10655488 DOI: 10.1073/Pnas.97.3.1085 |
0.324 |
|
| 1999 |
Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR. Spatial control of actin polymerization during neutrophil chemotaxis. Nature Cell Biology. 1: 75-81. PMID 10559877 DOI: 10.1038/10042 |
0.689 |
|
| 1999 |
Sheikh SP, Vilardarga JP, Baranski TJ, Lichtarge O, Iiri T, Meng EC, Nissenson RA, Bourne HR. Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. The Journal of Biological Chemistry. 274: 17033-41. PMID 10358054 DOI: 10.1074/Jbc.274.24.17033 |
0.349 |
|
| 1999 |
Baranski TJ, Herzmark P, Lichtarge O, Gerber BO, Trueheart J, Meng EC, Iiri T, Sheikh SP, Bourne HR. C5a receptor activation. Genetic identification of critical residues in four transmembrane helices. The Journal of Biological Chemistry. 274: 15757-65. PMID 10336477 DOI: 10.1074/Jbc.274.22.15757 |
0.348 |
|
| 1999 |
Servant G, Weiner OD, Neptune ER, Sedat JW, Bourne HR. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Molecular Biology of the Cell. 10: 1163-78. PMID 10198064 DOI: 10.1091/Mbc.10.4.1163 |
0.721 |
|
| 1999 |
Farfel Z, Bourne HR, Iiri T. The expanding spectrum of G protein diseases. The New England Journal of Medicine. 340: 1012-20. PMID 10099144 DOI: 10.1056/Nejm199904013401306 |
0.312 |
|
| 1999 |
Neptune ER, Iiri T, Bourne HR. Galphai is not required for chemotaxis mediated by Gi-coupled receptors. The Journal of Biological Chemistry. 274: 2824-8. PMID 9915816 DOI: 10.1074/Jbc.274.5.2824 |
0.397 |
|
| 1999 |
Iiri T, Bell SM, Baranski TJ, Fujita T, Bourne HR. A Gsalpha mutant designed to inhibit receptor signaling through Gs. Proceedings of the National Academy of Sciences of the United States of America. 96: 499-504. PMID 9892662 DOI: 10.1073/Pnas.96.2.499 |
0.453 |
|
| 1998 |
Apanovitch DM, Iiri T, Karasawa T, Bourne HR, Dohlman HG. Second site suppressor mutations of a GTPase-deficient G-protein alpha-subunit. Selective inhibition of Gbeta gamma-mediated signaling. The Journal of Biological Chemistry. 273: 28597-602. PMID 9786851 DOI: 10.1074/Jbc.273.44.28597 |
0.409 |
|
| 1998 |
Iiri T, Farfel Z, Bourne HR. G-protein diseases furnish a model for the turn-on switch. Nature. 394: 35-8. PMID 9665125 DOI: 10.1038/27831 |
0.389 |
|
| 1998 |
Morales J, Fishburn CS, Wilson PT, Bourne HR. Plasma membrane localization of G alpha z requires two signals. Molecular Biology of the Cell. 9: 1-14. PMID 9436987 DOI: 10.1091/Mbc.9.1.1 |
0.428 |
|
| 1998 |
Iiri T, Bourne HR. G proteins propel surprise. Nature Genetics. 18: 8-10. PMID 9425887 DOI: 10.1038/Ng0198-8 |
0.308 |
|
| 1997 |
Neptune ER, Bourne HR. Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs. Proceedings of the National Academy of Sciences of the United States of America. 94: 14489-94. PMID 9405640 DOI: 10.1073/Pnas.94.26.14489 |
0.332 |
|
| 1997 |
Bourne HR. G proteins. The arginine finger strikes again. Nature. 389: 673-4. PMID 9338774 DOI: 10.1038/39470 |
0.313 |
|
| 1997 |
Iiri T, Farfel Z, Bourne HR. Conditional activation defect of a human Gsalpha mutant. Proceedings of the National Academy of Sciences of the United States of America. 94: 5656-61. PMID 9159128 DOI: 10.1073/Pnas.94.11.5656 |
0.438 |
|
| 1997 |
Yan Y, Chi PP, Bourne HR. RGS4 inhibits Gq-mediated activation of mitogen-activated protein kinase and phosphoinositide synthesis. The Journal of Biological Chemistry. 272: 11924-7. PMID 9115254 DOI: 10.1074/Jbc.272.18.11924 |
0.438 |
|
| 1997 |
Bourne HR. How receptors talk to trimeric G proteins. Current Opinion in Cell Biology. 9: 134-42. PMID 9069253 DOI: 10.1016/S0955-0674(97)80054-3 |
0.395 |
|
| 1997 |
Onrust R, Herzmark P, Chi P, Garcia PD, Lichtarge O, Kingsley C, Bourne HR. Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin. Science (New York, N.Y.). 275: 381-4. PMID 8994033 DOI: 10.1126/Science.275.5298.381 |
0.387 |
|
| 1996 |
Iiri T, Backlund PS, Jones TL, Wedegaertner PB, Bourne HR. Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit. Proceedings of the National Academy of Sciences of the United States of America. 93: 14592-7. PMID 8962097 DOI: 10.1073/Pnas.93.25.14592 |
0.698 |
|
| 1996 |
Conklin BR, Herzmark P, Ishida S, Voyno-Yasenetskaya TA, Sun Y, Farfel Z, Bourne HR. Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation. Molecular Pharmacology. 50: 885-90. PMID 8863834 |
0.577 |
|
| 1996 |
Wedegaertner PB, Bourne HR, von Zastrow M. Activation-induced subcellular redistribution of Gs alpha. Molecular Biology of the Cell. 7: 1225-33. PMID 8856666 DOI: 10.1091/Mbc.7.8.1225 |
0.705 |
|
| 1996 |
Sheikh SP, Zvyaga TA, Lichtarge O, Sakmar TP, Bourne HR. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature. 383: 347-50. PMID 8848049 DOI: 10.1038/383347A0 |
0.357 |
|
| 1996 |
Lichtarge O, Bourne HR, Cohen FE. Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex. Proceedings of the National Academy of Sciences of the United States of America. 93: 7507-11. PMID 8755504 DOI: 10.1073/Pnas.93.15.7507 |
0.333 |
|
| 1996 |
Voyno-Yasenetskaya TA, Faure MP, Ahn NG, Bourne HR. Galpha12 and Galpha13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells. The Journal of Biological Chemistry. 271: 21081-7. PMID 8702875 DOI: 10.1074/Jbc.271.35.21081 |
0.352 |
|
| 1996 |
Farfel Z, Iiri T, Shapira H, Roitman A, Mouallem M, Bourne HR. Pseudohypoparathyroidism, a novel mutation in the betagamma-contact region of Gsalpha impairs receptor stimulation. The Journal of Biological Chemistry. 271: 19653-5. PMID 8702665 DOI: 10.1074/Jbc.271.33.19653 |
0.442 |
|
| 1996 |
Lichtarge O, Bourne HR, Cohen FE. An evolutionary trace method defines binding surfaces common to protein families. Journal of Molecular Biology. 257: 342-58. PMID 8609628 DOI: 10.1006/Jmbi.1996.0167 |
0.303 |
|
| 1995 |
Pace AM, Faure M, Bourne HR. Gi2-mediated activation of the MAP kinase cascade. Molecular Biology of the Cell. 6: 1685-95. PMID 8590798 DOI: 10.1091/Mbc.6.12.1685 |
0.424 |
|
| 1995 |
Bourne HR. GTPases: a family of molecular switches and clocks. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 349: 283-9. PMID 8577839 DOI: 10.1098/Rstb.1995.0114 |
0.35 |
|
| 1995 |
Iiri T, Homma Y, Ohoka Y, Robishaw JD, Katada T, Bourne HR. Potentiation of Gi-mediated phospholipase C activation by retinoic acid in HL-60 cells. Possible role of G gamma 2. The Journal of Biological Chemistry. 270: 5901-8. PMID 7890721 DOI: 10.1074/Jbc.270.11.5901 |
0.362 |
|
| 1995 |
Wedegaertner PB, Wilson PT, Bourne HR. Lipid modifications of trimeric G proteins. The Journal of Biological Chemistry. 270: 503-6. PMID 7822269 DOI: 10.1074/Jbc.270.2.503 |
0.679 |
|
| 1995 |
Wong YH, Chan JS, Yung LY, Bourne HR. Mutant alpha subunit of Gz transforms Swiss 3T3 cells. Oncogene. 10: 1927-33. PMID 7761094 |
0.311 |
|
| 1995 |
Faure M, Bourne HR. Differential effects on cAMP on the MAP kinase cascade: evidence for a cAMP-insensitive step that can bypass Raf-1. Molecular Biology of the Cell. 6: 1025-35. PMID 7579705 DOI: 10.1091/Mbc.6.8.1025 |
0.348 |
|
| 1995 |
Garcia PD, Onrust R, Bell SM, Sakmar TP, Bourne HR. Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells. The Embo Journal. 14: 4460-9. PMID 7556089 DOI: 10.1002/J.1460-2075.1995.Tb00125.X |
0.401 |
|
| 1995 |
Wilson PT, Bourne HR. Fatty acylation of alpha z. Effects of palmitoylation and myristoylation on alpha z signaling. The Journal of Biological Chemistry. 270: 9667-75. PMID 7536745 DOI: 10.1074/Jbc.270.16.9667 |
0.397 |
|
| 1995 |
Benjamin DR, Markby DW, Bourne HR, Kuntz ID. Solution structure of the GTPase activating domain of alpha s. Journal of Molecular Biology. 254: 681-91. PMID 7500342 DOI: 10.1006/Jmbi.1995.0647 |
0.357 |
|
| 1995 |
Bourne HR. Trimeric G proteins: surprise witness tells a tale. Science (New York, N.Y.). 270: 933-4. PMID 7481796 DOI: 10.1126/Science.270.5238.933 |
0.357 |
|
| 1994 |
Bourne HR. G proteins. The importance of being GTP. Nature. 369: 611-2. PMID 8208286 DOI: 10.1038/369611A0 |
0.317 |
|
| 1994 |
Faure M, Voyno-Yasenetskaya TA, Bourne HR. cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. The Journal of Biological Chemistry. 269: 7851-4. PMID 8132501 |
0.316 |
|
| 1994 |
Conklin BR, Bourne HR. Homeostatic signals. Marriage of the flytrap and the serpent. Nature. 367: 22. PMID 8107768 DOI: 10.1038/367022A0 |
0.527 |
|
| 1994 |
Voyno-Yasenetskaya T, Conklin BR, Gilbert RL, Hooley R, Bourne HR, Barber DL. G alpha 13 stimulates Na-H exchange. The Journal of Biological Chemistry. 269: 4721-4. PMID 8106440 |
0.604 |
|
| 1994 |
Iiri T, Herzmark P, Nakamoto JM, van Dop C, Bourne HR. Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function. Nature. 371: 164-8. PMID 8072545 DOI: 10.1038/371164A0 |
0.412 |
|
| 1994 |
Reuveny E, Slesinger PA, Inglese J, Morales JM, Iñiguez-Lluhi JA, Lefkowitz RJ, Bourne HR, Jan YN, Jan LY. Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature. 370: 143-6. PMID 8022483 DOI: 10.1038/370143A0 |
0.362 |
|
| 1994 |
Wedegaertner PB, Bourne HR. Activation and depalmitoylation of Gs alpha. Cell. 77: 1063-70. PMID 7912657 DOI: 10.1016/0092-8674(94)90445-6 |
0.687 |
|
| 1994 |
Chabre O, Conklin BR, Brandon S, Bourne HR, Limbird LE. Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system. The Journal of Biological Chemistry. 269: 5730-4. PMID 7907086 |
0.608 |
|
| 1994 |
Ma YH, Landis C, Tchao N, Wang J, Rodd G, Hanahan D, Bourne HR, Grodsky GM. Constitutively active stimulatory G-protein alpha s in beta-cells of transgenic mice causes counterregulation of the increased adenosine 3',5'-monophosphate and insulin secretion. Endocrinology. 134: 42-7. PMID 7506212 DOI: 10.1210/Endo.134.1.7506212 |
0.318 |
|
| 1994 |
Conklin BR, Bourne HR. Marriage of the flytrap and the serpent Nature. 367: 22. |
0.432 |
|
| 1993 |
Lustig KD, Conklin BR, Herzmark P, Taussig R, Bourne HR. Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq. The Journal of Biological Chemistry. 268: 13900-5. PMID 8390980 |
0.582 |
|
| 1993 |
Conklin BR, Bourne HR. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. Cell. 73: 631-41. PMID 8388779 DOI: 10.1016/0092-8674(93)90245-L |
0.599 |
|
| 1993 |
Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR. Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 363: 274-6. PMID 8387644 DOI: 10.1038/363274A0 |
0.628 |
|
| 1993 |
Conklin BR, Bourne HR. Mouse coat colour reconsidered. Nature. 364: 110. PMID 8321283 DOI: 10.1038/364110B0 |
0.489 |
|
| 1993 |
Markby DW, Onrust R, Bourne HR. Separate GTP binding and GTPase activating domains of a G alpha subunit. Science (New York, N.Y.). 262: 1895-901. PMID 8266082 DOI: 10.1126/Science.8266082 |
0.416 |
|
| 1993 |
Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR. Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. The Journal of Biological Chemistry. 268: 25001-8. PMID 8227063 |
0.668 |
|
| 1993 |
Bourne HR, Nicoll R. Molecular machines integrate coincident synaptic signals. Cell. 72: 65-75. PMID 8094038 DOI: 10.1016/S0092-8674(05)80029-7 |
0.306 |
|
| 1992 |
Berlot CH, Bourne HR. Identification of effector-activating residues of Gs alpha. Cell. 68: 911-22. PMID 1547491 DOI: 10.1016/0092-8674(92)90034-A |
0.41 |
|
| 1992 |
Wong YH, Conklin BR, Bourne HR. Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science (New York, N.Y.). 255: 339-42. PMID 1347957 DOI: 10.1126/Science.1347957 |
0.65 |
|
| 1992 |
Bourne HR, Lustig KD, Wong YH, Conklin BR. Detection of coincident signals by G proteins and adenylyl cyclase. Cold Spring Harbor Symposia On Quantitative Biology. 57: 145-8. PMID 1339653 DOI: 10.1101/Sqb.1992.057.01.018 |
0.577 |
|
| 1992 |
Chabre O, Conklin BR, Lin HY, Lodish HF, Wilson E, Ives HE, Catanzariti L, Hemmings BA, Bourne HR. A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Molecular Endocrinology (Baltimore, Md.). 6: 551-6. PMID 1316547 DOI: 10.1210/Mend.6.4.1316547 |
0.571 |
|
| 1992 |
Federman AD, Conklin BR, Schrader KA, Reed RR, Bourne HR. Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature. 356: 159-61. PMID 1312225 DOI: 10.1038/356159A0 |
0.636 |
|
| 1992 |
Conklin BR, Chabre O, Wong YH, Federman AD, Bourne HR. Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C. The Journal of Biological Chemistry. 267: 31-4. PMID 1309740 |
0.578 |
|
| 1992 |
Levis MJ, Bourne HR. Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity. The Journal of Cell Biology. 119: 1297-307. PMID 1280272 DOI: 10.1083/Jcb.119.5.1297 |
0.427 |
|
| 1991 |
Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: conserved structure and molecular mechanism. Nature. 349: 117-27. PMID 1898771 DOI: 10.1038/349117A0 |
0.448 |
|
| 1991 |
Wong YH, Federman A, Pace AM, Zachary I, Evans T, Pouysségur J, Bourne HR. Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation. Nature. 351: 63-5. PMID 1851251 DOI: 10.1038/351063A0 |
0.412 |
|
| 1991 |
Pace AM, Wong YH, Bourne HR. A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 7031-5. PMID 1651490 DOI: 10.1073/Pnas.88.16.7031 |
0.389 |
|
| 1990 |
Bourne HR. ADP-Ribosylating Toxins and G Proteins. Insights into Signal Transduction. Joel Moss and Martha Vaughan, Eds. American Society for Microbiology, Washington, DC, 1990. xviii, 567 pp., illus. $79; to ASM members, $69. Science (New York, N.Y.). 250: 841-2. PMID 17759980 DOI: 10.1126/Science.250.4982.841-A |
0.31 |
|
| 1990 |
Heideman W, Casperson GF, Bourne HR. Adenylyl cyclase in yeast: antibodies and mutations identify a regulatory domain. Journal of Cellular Biochemistry. 42: 229-42. PMID 2187889 DOI: 10.1002/Jcb.240420406 |
0.363 |
|
| 1990 |
Zachary I, Masters SB, Bourne HR. Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gs alpha. Biochemical and Biophysical Research Communications. 168: 1184-93. PMID 2161217 DOI: 10.1016/0006-291X(90)91154-K |
0.448 |
|
| 1990 |
Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature. 348: 125-32. PMID 2122258 DOI: 10.1038/348125A0 |
0.504 |
|
| 1990 |
Masters SB, Landis CA, Bourne HR. Mutational analysis of the structure and function of GTP-binding proteins. Advances in Enzyme Regulation. 30: 75-87. PMID 2119552 DOI: 10.1016/0065-2571(90)90010-Y |
0.402 |
|
| 1990 |
Lyons J, Landis CA, Harsh G, Vallar L, Grünewald K, Feichtinger H, Duh QY, Clark OH, Kawasaki E, Bourne HR. Two G protein oncogenes in human endocrine tumors. Science (New York, N.Y.). 249: 655-9. PMID 2116665 DOI: 10.1126/Science.2116665 |
0.362 |
|
| 1990 |
Jones DT, Masters SB, Bourne HR, Reed RR. Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf. The Journal of Biological Chemistry. 265: 2671-6. PMID 2105931 |
0.334 |
|
| 1989 |
Bourne HR. G-protein subunits. Who carries what message? Nature. 337: 504. PMID 2644543 DOI: 10.1038/337504A0 |
0.335 |
|
| 1989 |
Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature. 340: 692-6. PMID 2549426 DOI: 10.1038/340692A0 |
0.427 |
|
| 1989 |
Masters SB, Miller RT, Chi MH, Chang FH, Beiderman B, Lopez NG, Bourne HR. Mutations in the GTP-binding site of GS alpha alter stimulation of adenylyl cyclase. The Journal of Biological Chemistry. 264: 15467-74. PMID 2549064 |
0.306 |
|
| 1989 |
Chang FH, Bourne HR. Cholera toxin induces cAMP-independent degradation of Gs. The Journal of Biological Chemistry. 264: 5352-7. PMID 2538415 |
0.306 |
|
| 1989 |
Bourne HR, Landis CA, Masters SB. Hydrolysis of GTP by the alpha-chain of Gs and other GTP binding proteins. Proteins. 6: 222-30. PMID 2516316 DOI: 10.1002/Prot.340060304 |
0.427 |
|
| 1988 |
Bourne HR, Masters SB, Miller RT, Sullivan KA, Heideman W. Mutations probe structure and function of G-protein alpha chains. Cold Spring Harbor Symposia On Quantitative Biology. 53: 221-8. PMID 3151169 DOI: 10.1101/Sqb.1988.053.01.028 |
0.4 |
|
| 1988 |
Miller RT, Masters SB, Sullivan KA, Beiderman B, Bourne HR. A mutation that prevents GTP-dependent activation of the alpha chain of Gs. Nature. 334: 712-5. PMID 3137475 DOI: 10.1038/334712A0 |
0.45 |
|
| 1988 |
Yu VC, Hochhaus G, Chang FH, Richards ML, Bourne HR, Sadée W. Differentiation of human neuroblastoma cells: marked potentiation of prostaglandin E-stimulated accumulation of cyclic AMP by retinoic acid. Journal of Neurochemistry. 51: 1892-9. PMID 2903224 DOI: 10.1111/J.1471-4159.1988.Tb01174.X |
0.315 |
|
| 1988 |
Masters SB, Sullivan KA, Miller RT, Beiderman B, Lopez NG, Ramachandran J, Bourne HR. Carboxyl terminal domain of Gs alpha specifies coupling of receptors to stimulation of adenylyl cyclase. Science (New York, N.Y.). 241: 448-51. PMID 2899356 DOI: 10.1126/Science.2899356 |
0.404 |
|
| 1987 |
Chang FH, Bourne HR. Dexamethasone increases adenylyl cyclase activity and expression of the alpha-subunit of Gs in GH3 cells. Endocrinology. 121: 1711-5. PMID 3665842 DOI: 10.1210/Endo-121-5-1711 |
0.423 |
|
| 1987 |
Bourne HR, Masters SB, Sullivan KA. Mammalian G proteins: structure and function. Biochemical Society Transactions. 15: 35-8. PMID 3104111 DOI: 10.1042/Bst0150035 |
0.301 |
|
| 1987 |
Sullivan KA, Miller RT, Masters SB, Beiderman B, Heideman W, Bourne HR. Identification of receptor contact site involved in receptor-G protein coupling. Nature. 330: 758-60. PMID 2827032 DOI: 10.1038/330758A0 |
0.463 |
|
| 1986 |
Stryer L, Bourne HR. G proteins: a family of signal transducers. Annual Review of Cell Biology. 2: 391-419. PMID 3103658 DOI: 10.1146/Annurev.Cb.02.110186.002135 |
0.33 |
|
| 1986 |
Sullivan KA, Liao YC, Alborzi A, Beiderman B, Chang FH, Masters SB, Levinson AD, Bourne HR. Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proceedings of the National Academy of Sciences of the United States of America. 83: 6687-91. PMID 3092218 DOI: 10.1073/Pnas.83.18.6687 |
0.4 |
|
| 1986 |
Masters SB, Stroud RM, Bourne HR. Family of G protein α chains: amphipathic analysis and predicted structure of functional domains "Protein Engineering, Design and Selection". 1: 47-54. DOI: 10.1093/Protein/1.1.47 |
0.388 |
|
| 1985 |
Medynski DC, Sullivan K, Smith D, Van Dop C, Chang FH, Fung BK, Seeburg PH, Bourne HR. Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proceedings of the National Academy of Sciences of the United States of America. 82: 4311-5. PMID 2409555 DOI: 10.1073/Pnas.82.13.4311 |
0.331 |
|
| 1984 |
Bourne HR, Van Dop C, Casperson GF. Genetic and functional studies of guanine nucleotide-binding regulatory proteins. Advances in Experimental Medicine and Biology. 175: 85-98. PMID 6437161 DOI: 10.1007/978-1-4684-4805-4_7 |
0.351 |
|
| 1982 |
Motulsky HJ, Hughes RJ, Brickman AS, Farfel Z, Bourne HR, Insel PA. Platelets of pseudohypoparathyroid patients: evidence that distinct receptor-cyclase coupling proteins mediate stimulation and inhibition of adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 79: 4193-7. PMID 6287473 DOI: 10.1073/Pnas.79.13.4193 |
0.318 |
|
| 1982 |
Abood ME, Hurley JB, Pappone MC, Bourne HR, Stryer L. Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin. The Journal of Biological Chemistry. 257: 10540-3. PMID 6125514 |
0.305 |
|
| 1981 |
Bourne HR, Kaslow HR, Brickman AS, Farfel Z. Fibroblast defect in pseudohypoparathyroidism, type I: reduced activity of receptor-cyclase coupling protein. The Journal of Clinical Endocrinology and Metabolism. 53: 636-40. PMID 6267099 DOI: 10.1210/Jcem-53-3-636 |
0.309 |
|
| 1981 |
Farfel Z, Brothers VM, Brickman AS, Conte F, Neer R, Bourne HR. Pseudohypoparathyroidism: inheritance of deficient receptor-cyclase coupling activity. Proceedings of the National Academy of Sciences of the United States of America. 78: 3098-102. PMID 6265935 DOI: 10.1073/Pnas.78.5.3098 |
0.336 |
|
| 1980 |
Kaslow HR, Johnson GL, Brothers VM, Bourne HR. A regulatory component of adenylate cyclase from human erythrocyte membranes. The Journal of Biological Chemistry. 255: 3736-41. PMID 7364766 |
0.405 |
|
| 1980 |
Farfel Z, Bourne HR. Deficient activity of receptor-cyclase coupling protein in platelets of patients with pseudohypoparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 51: 1202-4. PMID 6252235 DOI: 10.1210/Jcem-51-5-1202 |
0.331 |
|
| 1980 |
Johnson GL, Kaslow HR, Farfel Z, Bourne HR. Genetic analysis of hormone-sensitive adenylate cyclase. Advances in Cyclic Nucleotide Research. 13: 1-37. PMID 6251703 |
0.376 |
|
| 1980 |
Farfel Z, Brickman AS, Kaslow HR, Brothers VM, Bourne HR. Defect of receptor-cyclase coupling protein in psudohypoparathyroidism. The New England Journal of Medicine. 303: 237-42. PMID 6247654 DOI: 10.1056/Nejm198007313030501 |
0.364 |
|
| 1979 |
Kaiser N, Bourne HR, Insel PA, Coffino P. Regulation of phosphodiesterase and ornithine decarboxylase by cAMP is cell cycle independent. Journal of Cellular Physiology. 101: 369-74. PMID 231036 DOI: 10.1002/Jcp.1041010304 |
0.335 |
|
| 1979 |
Kaslow HR, Farfel Z, Johnson GL, Bourne HR. Adenylate cyclase assembled in vitro: cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5'-triphosphate. Molecular Pharmacology. 15: 472-83. PMID 226858 |
0.405 |
|
| 1979 |
Johnson GL, Bourne HR, Gleason MK, Coffino P, Insel PA, Melmon KL. Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase. Molecular Pharmacology. 15: 16-27. PMID 34089 |
0.453 |
|
| 1978 |
Johnson GL, Kaslow HR, Bourne HR. Reconstitution of cholera toxin-activated adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 75: 3113-7. PMID 277913 DOI: 10.1073/Pnas.75.7.3113 |
0.518 |
|
| 1978 |
Johnson GL, Kaslow HR, Bourne HR. Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase. The Journal of Biological Chemistry. 253: 7120-3. PMID 212417 |
0.487 |
|
| 1978 |
Naya-Vigne J, Johnson GL, Bourne HR, Coffino P. Complementation analysis of hormone-sensitive adenylate cyclase. Nature. 272: 720-2. PMID 205796 DOI: 10.1038/272720A0 |
0.528 |
|
| 1977 |
Johnson GL, Bourne HR. Influence of cholera toxin on the regulation of adenylate cyclase by GTP. Biochemical and Biophysical Research Communications. 78: 792-8. PMID 199187 DOI: 10.1016/0006-291X(77)90249-2 |
0.53 |
|
| 1977 |
Hochman J, Bourne HR, Coffino P, Insel PA, Krasny L, Melmon KL. Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 74: 1167-71. PMID 191831 DOI: 10.1073/Pnas.74.3.1167 |
0.339 |
|
| 1976 |
Coffino P, Bourne HR, Friedrich U, Hochman J, Insel PA, Lemaire I, Melmon KL, Tomkins GM. Molecular mechanisms of cyclic AMP action: a genetic approach. Recent Progress in Hormone Research. 32: 669-84. PMID 183250 DOI: 10.1016/B978-0-12-571132-6.50037-3 |
0.321 |
|
| 1975 |
Kram JA, Bourne HR, Maibach HI, Melmon KL. Cutaneous immediate hypersensitivity in man: effects of systemically administered adrenergic drugs. The Journal of Allergy and Clinical Immunology. 56: 387-92. PMID 241760 DOI: 10.1016/0091-6749(75)90132-3 |
0.323 |
|
| 1975 |
Hochman J, Insel PA, Bourne HR, Coffino P, Tomkins GM. A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 72: 5051-5. PMID 174091 DOI: 10.1073/Pnas.72.12.5051 |
0.357 |
|
| 1975 |
Insel PA, Bourne HR, Coffino P, Tomkins GM. Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth. Science (New York, N.Y.). 190: 896-8. PMID 171770 DOI: 10.1126/Science.171770 |
0.346 |
|
| 1975 |
Bourne HR, Coffino P, Tomkins GM. Somatic genetic analysis of cyclic AMP action: characterization of unresponsive mutants. Journal of Cellular Physiology. 85: 611-20. PMID 167037 DOI: 10.1002/Jcp.1040850313 |
0.346 |
|
| 1975 |
Coffino P, Bourne HR, Tomkins GM. Somatic genetic analysis of cyclic AMP action: selection of unresponsive mutants. Journal of Cellular Physiology. 85: 603-10. PMID 167036 DOI: 10.1002/Jcp.1040850312 |
0.333 |
|
| 1975 |
Bourne HR, Coffino P, Tomkins GM. Selection of a variant lymphoma cell deficient in adenylate cyclase. Science (New York, N.Y.). 187: 750-2. PMID 163487 DOI: 10.1126/Science.163487 |
0.314 |
|
| 1974 |
Melmon KL, Weinstein Y, Shearer GM, Bourne HR, Bauminger S. Separation of specific antibody-forming mouse cells by their adherence to insolubilized endogenous hormones. The Journal of Clinical Investigation. 53: 22-30. PMID 4357614 DOI: 10.1172/Jci107542 |
0.345 |
|
| 1974 |
Melmon KL, Bourne HR, Weinstein Y, Shearer GM, Kram J, Bauminger S. Hemolytic plaque formation by leukocytes in vitro. Control by vasoactive hormones. The Journal of Clinical Investigation. 53: 13-21. PMID 4357609 DOI: 10.1172/Jci107530 |
0.32 |
|
| 1973 |
Bourne HR, Tomkins GM, Dion S. Regulation of phosphodiesterase synthesis: requirement for cyclic adenosine monophosphate-dependent protein kinase. Science (New York, N.Y.). 181: 952-4. PMID 4354229 DOI: 10.1126/Science.181.4103.952 |
0.344 |
|
| 1973 |
Daniel V, Bourne HR, Tomkins GM. Altered metabolism and endogenous cyclic AMP in cultured cells deficient in cyclic AMP-binding proteins. Nature: New Biology. 244: 167-9. PMID 4353421 DOI: 10.1038/Newbio244167A0 |
0.352 |
|
| 1973 |
Weinstein Y, Melmon KL, Bourne HR, Sela M. Specific leukocyte receptors for small endogenous hormones. Detection by cell binding to insolubilized hormone preparations. The Journal of Clinical Investigation. 52: 1349-61. PMID 4145025 DOI: 10.1172/Jci107307 |
0.337 |
|
| 1973 |
Bourne HR, Lehrer RI, Lichtenstein LM, Weissmann G, Zurier R. Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase. The Journal of Clinical Investigation. 52: 698-708. PMID 4119468 DOI: 10.1172/Jci107231 |
0.347 |
|
| 1973 |
Lichtenstein LM, Henney CS, Bourne HR, Greenough WB. Effects of cholera toxin on in vitro models of immediate and delayed hypersensitivity. Further evidence for the role of cyclic adenosine 3',5'-monophosphate. The Journal of Clinical Investigation. 52: 691-7. PMID 4119467 DOI: 10.1172/Jci107230 |
0.323 |
|
| 1972 |
Melmon KL, Bourne HR, Weinstein J, Sela M. Receptors for histamine can be detected on the surface of selected leukocytes. Science (New York, N.Y.). 177: 707-9. PMID 4403369 DOI: 10.1126/Science.177.4050.707 |
0.334 |
|
| 1971 |
Bourne HR, Lehrer RI, Cline MJ, Melmon KL. Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity. The Journal of Clinical Investigation. 50: 920-9. PMID 4323128 DOI: 10.1172/Jci106564 |
0.302 |
|
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