| Year |
Citation |
Score |
| 2024 |
Sweeney KM, Chantarawong S, Barbieri EM, Cajka G, Liu M, Spruce L, Fazelinia H, Portz B, Copley K, Lapidot T, Duhamel L, Greenwald P, Saida N, Shalgi R, Shorter J, et al. CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. Plos Genetics. 20: e1011138. PMID 38315730 DOI: 10.1371/journal.pgen.1011138 |
0.305 |
|
| 2024 |
Khalil B, Linsenmeier M, Smith CL, Shorter J, Rossoll W. Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD. Molecular Neurodegeneration. 19: 8. PMID 38254150 DOI: 10.1186/s13024-023-00698-1 |
0.311 |
|
| 2023 |
Guo L, Mann JR, Mauna JC, Copley KE, Wang H, Rubien JD, Odeh HM, Lin J, Lee BL, Ganser L, Robinson E, Kim KM, Murthy AC, Paul T, Portz B, ... ... Shorter J, et al. Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. Biorxiv : the Preprint Server For Biology. PMID 37732211 DOI: 10.1101/2023.09.04.555754 |
0.787 |
|
| 2023 |
Mack KL, Kim H, Barbieri EM, Lin J, Braganza S, Jackrel ME, DeNizio JE, Yan X, Chuang E, Tariq A, Cupo RR, Castellano LM, Caldwell KA, Caldwell GA, Shorter J. Tuning Hsp104 specificity to selectively detoxify α-synuclein. Molecular Cell. PMID 37625404 DOI: 10.1016/j.molcel.2023.07.029 |
0.812 |
|
| 2023 |
Sharma K, Banerjee S, Savran D, Rajes C, Wiese S, Girdhar A, Schwierz N, Lee C, Shorter J, Schmidt M, Guo L, Fändrich M. Cryo-EM structure of the full-length hnRNPA1 amyloid fibril. Journal of Molecular Biology. 168211. PMID 37481159 DOI: 10.1016/j.jmb.2023.168211 |
0.824 |
|
| 2023 |
Balendra R, Ruiz de Los Mozos I, Odeh HM, Glaria I, Milioto C, Wilson KM, Ule AM, Hallegger M, Masino L, Martin S, Patani R, Shorter J, Ule J, Isaacs AM. Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides. Life Science Alliance. 6. PMID 37438085 DOI: 10.26508/lsa.202201824 |
0.72 |
|
| 2023 |
Rhine K, Odeh HM, Shorter J, Myong S. Regulation of Biomolecular Condensates by Poly(ADP-ribose). Chemical Reviews. PMID 37115110 DOI: 10.1021/acs.chemrev.2c00851 |
0.76 |
|
| 2023 |
Ervilha Pereira P, Schuermans N, Meylemans A, LeBlanc P, Versluys L, Copley KE, Rubien JD, Altheimer C, Peetermans M, Debackere E, Vanakker O, Janssens S, Baets J, Verhoeven K, Lammens M, ... ... Shorter J, et al. C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD. Acta Neuropathologica. PMID 37000196 DOI: 10.1007/s00401-023-02565-1 |
0.776 |
|
| 2023 |
Copley KE, Shorter J. Repetitive elements in aging and neurodegeneration. Trends in Genetics : Tig. PMID 36935218 DOI: 10.1016/j.tig.2023.02.008 |
0.751 |
|
| 2023 |
Boeynaems S, Chong S, Gsponer J, Holt L, Milovanovic D, Mitrea DM, Mueller-Cajar O, Portz B, Reilly JF, Reinkemeier CD, Sabari BR, Sanulli S, Shorter J, Sontag E, Strader L, et al. Phase Separation in Biology and Disease; Current Perspectives and Open Questions. Journal of Molecular Biology. 435: 167971. PMID 36690068 DOI: 10.1016/j.jmb.2023.167971 |
0.765 |
|
| 2022 |
Fare CM, Rhine K, Lam A, Myong S, Shorter J. A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity. The Journal of Biological Chemistry. 102806. PMID 36529289 DOI: 10.1016/j.jbc.2022.102806 |
0.818 |
|
| 2022 |
Cupo RR, Rizo AN, Braun GA, Tse E, Chuang E, Gupta K, Southworth DR, Shorter J. Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3. Cell Reports. 40: 111408. PMID 36170828 DOI: 10.1016/j.celrep.2022.111408 |
0.824 |
|
| 2022 |
Shen H, Yanas A, Owens MC, Zhang C, Fritsch C, Fare CM, Copley KE, Shorter J, Goldman YE, Liu KF. Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation. Molecular Cell. PMID 35588748 DOI: 10.1016/j.molcel.2022.04.022 |
0.793 |
|
| 2022 |
François-Moutal L, Scott DD, Ambrose AJ, Zerio CJ, Rodriguez-Sanchez M, Dissanayake K, May DG, Carlson JM, Barbieri E, Moutal A, Roux KJ, Shorter J, Khanna R, Barmada SJ, McGurk L, et al. Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology. Scientific Reports. 12: 8140. PMID 35581326 DOI: 10.1038/s41598-022-12191-8 |
0.706 |
|
| 2022 |
Peinado JR, Chaplot K, Jarvela TS, Barbieri EM, Shorter J, Lindberg I. Sequestration of TDP-43 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone. Acs Chemical Neuroscience. PMID 35549000 DOI: 10.1021/acschemneuro.2c00156 |
0.677 |
|
| 2022 |
Kim HJ, Mohassel P, Donkervoort S, Guo L, O'Donovan K, Coughlin M, Lornage X, Foulds N, Hammans SR, Foley AR, Fare CM, Ford AF, Ogasawara M, Sato A, Iida A, ... ... Shorter J, et al. Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy. Nature Communications. 13: 2306. PMID 35484142 DOI: 10.1038/s41467-022-30015-1 |
0.82 |
|
| 2022 |
Copley KE, Shorter J. Flying under the radar: TMEM106B(120-254) fibrils break out in diverse neurodegenerative disorders. Cell. 185: 1290-1292. PMID 35427496 DOI: 10.1016/j.cell.2022.03.032 |
0.781 |
|
| 2022 |
Lin J, Shorter J, Lucius AL. AAA+ proteins: one motor, multiple ways to work. Biochemical Society Transactions. PMID 35356966 DOI: 10.1042/BST20200350 |
0.803 |
|
| 2022 |
Ma XR, Prudencio M, Koike Y, Vatsavayai SC, Kim G, Harbinski F, Briner A, Rodriguez CM, Guo C, Akiyama T, Schmidt HB, Cummings BB, Wyatt DW, Kurylo K, Miller G, ... ... Shorter J, et al. TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A. Nature. PMID 35197626 DOI: 10.1038/s41586-022-04424-7 |
0.566 |
|
| 2022 |
Rhine K, Dasovich M, Yoniles J, Badiee M, Skanchy S, Ganser LR, Ge Y, Fare CM, Shorter J, Leung AKL, Myong S. Poly(ADP-ribose) drives condensation of FUS via a transient interaction. Molecular Cell. PMID 35182479 DOI: 10.1016/j.molcel.2022.01.018 |
0.798 |
|
| 2022 |
Odeh HM, Shorter J. Aggregates of TDP-43 protein spiral into view. Nature. 601: 29-30. PMID 34880481 DOI: 10.1038/d41586-021-03605-0 |
0.76 |
|
| 2021 |
Gottlieb L, Guo L, Shorter J, Marmorstein R. N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate. The Journal of Biological Chemistry. 297: 101363. PMID 34732320 DOI: 10.1016/j.jbc.2021.101363 |
0.425 |
|
| 2021 |
Odeh HM, Fare CM, Shorter J. Nuclear-import receptors counter deleterious phase transitions in neurodegenerative disease. Journal of Molecular Biology. 167220. PMID 34464655 DOI: 10.1016/j.jmb.2021.167220 |
0.828 |
|
| 2021 |
Huang L, Agrawal T, Zhu G, Yu S, Tao L, Lin J, Marmorstein R, Shorter J, Yang X. DAXX represents a new type of protein-folding enabler. Nature. PMID 34408321 DOI: 10.1038/s41586-021-03824-5 |
0.777 |
|
| 2021 |
Hallegger M, Chakrabarti AM, Lee FCY, Lee BL, Amalietti AG, Odeh HM, Copley KE, Rubien JD, Portz B, Kuret K, Huppertz I, Rau F, Patani R, Fawzi NL, Shorter J, et al. TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell. PMID 34380047 DOI: 10.1016/j.cell.2021.07.018 |
0.805 |
|
| 2021 |
Beijer D, Kim HJ, Guo L, O'Donovan K, Mademan I, Deconinck T, Van Schil K, Fare CM, Drake LE, Ford AF, Kochański A, Kabzińska D, Dubuisson N, Van den Bergh P, Voermans NC, ... ... Shorter J, et al. Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation. Jci Insight. 6. PMID 34291734 DOI: 10.1172/jci.insight.148363 |
0.807 |
|
| 2021 |
Fare CM, Villani A, Drake LE, Shorter J. Higher-order organization of biomolecular condensates. Open Biology. 11: 210137. PMID 34129784 DOI: 10.1098/rsob.210137 |
0.758 |
|
| 2021 |
Warren JT, Cupo RR, Wattanasirakul P, Spencer D, Locke AE, Makaryan V, Bolyard AA, Kelley ML, Kingston NL, Shorter J, Bellanné-Chantelot C, Donadieu J, Dale DC, Link DC. Heterozygous Variants of CLPB are a Cause of Severe Congenital Neutropenia. Blood. PMID 34115842 DOI: 10.1182/blood.2021010762 |
0.795 |
|
| 2021 |
Gorenberg EL, Shorter J. Tau heckles speckles: A pathogenic mechanism in tauopathy? Neuron. 109: 1585-1587. PMID 34015263 DOI: 10.1016/j.neuron.2021.04.022 |
0.803 |
|
| 2021 |
Fare CM, Shorter J. (Dis)Solving the problem of aberrant protein states. Disease Models & Mechanisms. 14. PMID 33942880 DOI: 10.1242/dmm.048983 |
0.816 |
|
| 2021 |
Fare CM, Shorter J. Open Access: A Role for p53 in c9ALS/FTD? Trends in Genetics : Tig. PMID 33551183 DOI: 10.1016/j.tig.2021.01.008 |
0.778 |
|
| 2021 |
Darling AL, Shorter J. Combating deleterious phase transitions in neurodegenerative disease. Biochimica Et Biophysica Acta. Molecular Cell Research. 118984. PMID 33549703 DOI: 10.1016/j.bbamcr.2021.118984 |
0.765 |
|
| 2021 |
Portz B, Lee BL, Shorter J. FUS and TDP-43 Phases in Health and Disease. Trends in Biochemical Sciences. PMID 33446423 DOI: 10.1016/j.tibs.2020.12.005 |
0.787 |
|
| 2020 |
Cupo RR, Shorter J. Expression and Purification of Recombinant Skd3 (Human ClpB) Protein and Tobacco Etch Virus (TEV) Protease from . Bio-Protocol. 10: e3858. PMID 33659495 DOI: 10.21769/BioProtoc.3858 |
0.813 |
|
| 2020 |
Robinson E, Shorter J, Guo L. Karyopherin-β2 Inhibits and Reverses Aggregation and Liquid-liquid Phase Separation of the ALS/FTD-Associated Protein FUS. Bio-Protocol. 10: e3725. PMID 33659387 DOI: 10.21769/BioProtoc.3725 |
0.472 |
|
| 2020 |
Portz B, Shorter J. Biochemical timekeeping via reentrant phase transitions. Journal of Molecular Biology. 166794. PMID 33387533 DOI: 10.1016/j.jmb.2020.166794 |
0.751 |
|
| 2020 |
Hutten S, Usluer S, Bourgeois B, Simonetti F, Odeh HM, Fare CM, Czuppa M, Hruska-Plochan M, Hofweber M, Polymenidou M, Shorter J, Edbauer D, Madl T, Dormann D. Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions. Cell Reports. 33: 108538. PMID 33357437 DOI: 10.1016/j.celrep.2020.108538 |
0.833 |
|
| 2020 |
Rhine K, Makurath MA, Liu J, Skanchy S, Lopez C, Catalan KF, Ma Y, Fare CM, Shorter J, Ha T, Chemla YR, Myong S. ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS. Molecular Cell. 80: 1139. PMID 33338404 DOI: 10.1016/j.molcel.2020.11.031 |
0.765 |
|
| 2020 |
March ZM, Sweeney K, Kim H, Yan X, Castellano LM, Jackrel ME, Lin J, Chuang E, Gomes E, Willicott CW, Michalska K, Jedrzejczak RP, Joachimiak A, Caldwell KA, Caldwell GA, ... ... Shorter J, et al. Therapeutic genetic variation revealed in diverse Hsp104 homologs. Elife. 9. PMID 33319748 DOI: 10.7554/eLife.57457 |
0.836 |
|
| 2020 |
Zhu G, Harischandra DS, Ghaisas S, Zhang P, Prall W, Huang L, Maghames C, Guo L, Luna E, Mack KL, Torrente MP, Luk KC, Shorter J, Yang X. TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease. Cell Reports. 33: 108418. PMID 33264628 DOI: 10.1016/j.celrep.2020.108418 |
0.836 |
|
| 2020 |
Cook CN, Wu Y, Odeh HM, Gendron TF, Jansen-West K, Del Rosso G, Yue M, Jiang P, Gomes E, Tong J, Daughrity LM, Avendano NM, Castanedes-Casey M, Shao W, Oskarsson B, ... ... Shorter J, et al. poly(GR) aggregation induces TDP-43 proteinopathy. Science Translational Medicine. 12. PMID 32878979 DOI: 10.1126/Scitranslmed.Abb3774 |
0.786 |
|
| 2020 |
Darling AL, Shorter J. Atomic Structures of Amyloid-β Oligomers Illuminate a Neurotoxic Mechanism. Trends in Neurosciences. PMID 32792144 DOI: 10.1016/J.Tins.2020.07.006 |
0.739 |
|
| 2020 |
Odeh HM, Shorter J. Arginine-rich dipeptide-repeat proteins as phase disruptors in C9-ALS/FTD. Emerging Topics in Life Sciences. PMID 32639008 DOI: 10.1042/ETLS20190167 |
0.734 |
|
| 2020 |
Cupo RR, Shorter J. Skd3 (human ) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations. Elife. 9. PMID 32573439 DOI: 10.7554/Elife.55279 |
0.832 |
|
| 2020 |
Lopez KE, Rizo AN, Tse E, Lin J, Scull NW, Thwin AC, Lucius AL, Shorter J, Southworth DR. Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nature Structural & Molecular Biology. PMID 32313240 DOI: 10.1038/S41594-020-0409-5 |
0.802 |
|
| 2020 |
Gitler AD, Shorter J, Ha T, Myong S. Just Took a DNA Test, Turns Out 100% Not That Phase. Molecular Cell. 78: 193-194. PMID 32302539 DOI: 10.1016/J.Molcel.2020.03.029 |
0.57 |
|
| 2020 |
Ye X, Lin J, Mayne L, Shorter J, Englander SW. Structural and kinetic basis for the regulation and potentiation of Hsp104 function. Proceedings of the National Academy of Sciences of the United States of America. PMID 32277033 DOI: 10.1073/Pnas.1921968117 |
0.776 |
|
| 2020 |
Odeh HM, Shorter J. The Sense of Targeting Nonsense-Mediated Decay in C9-ALS/FTD. Neuron. 106: 6-9. PMID 32272067 DOI: 10.1016/J.Neuron.2020.03.017 |
0.732 |
|
| 2020 |
Wobst HJ, Mack KL, Brown DG, Brandon NJ, Shorter J. The clinical trial landscape in amyotrophic lateral sclerosis-Past, present, and future. Medicinal Research Reviews. PMID 32043626 DOI: 10.1002/Med.21661 |
0.76 |
|
| 2020 |
Cupo RR, Shorter J. Author response: Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations Elife. DOI: 10.7554/Elife.55279.Sa2 |
0.79 |
|
| 2019 |
Brown DG, Shorter J, Wobst HJ. Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia. Bioorganic & Medicinal Chemistry Letters. 126942. PMID 31926785 DOI: 10.1016/J.Bmcl.2019.126942 |
0.38 |
|
| 2019 |
Sweeny EA, Tariq A, Gurpinar E, Go MS, Sochor MA, Kan ZY, Mayne L, Englander SW, Shorter J. Structural and mechanistic insights into Hsp104 function revealed by synchrotron x-ray footprinting. The Journal of Biological Chemistry. PMID 31882541 DOI: 10.1074/Jbc.Ra119.011577 |
0.793 |
|
| 2019 |
Jones RD, Enam C, Ibarra R, Borror HR, Mostoller KE, Fredrickson EK, Lin J, Chuang E, March Z, Shorter J, Ravid T, Kleiger G, Gardner RG. The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate. Molecular Biology of the Cell. mbcE18020121. PMID 31825716 DOI: 10.1091/Mbc.E18-02-0121 |
0.831 |
|
| 2019 |
Portz B, Shorter J. Switching Condensates: The CTD Code Goes Liquid. Trends in Biochemical Sciences. PMID 31734037 DOI: 10.1016/J.Tibs.2019.10.009 |
0.759 |
|
| 2019 |
Ryan JJ, Sprunger ML, Holthaus K, Shorter J, Jackrel ME. Correction: Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma. The Journal of Biological Chemistry. 294: 17707. PMID 31732685 DOI: 10.1074/jbc.AAC119.011523 |
0.805 |
|
| 2019 |
Niaki AG, Sarkar J, Cai X, Rhine K, Vidaurre V, Guy B, Hurst M, Lee JC, Koh HR, Guo L, Fare CM, Shorter J, Myong S. Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations. Molecular Cell. PMID 31630970 DOI: 10.1016/J.Molcel.2019.09.022 |
0.806 |
|
| 2019 |
Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, ... ... Shorter J, et al. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation. Neuron. PMID 31587919 DOI: 10.1016/J.Neuron.2019.09.003 |
0.788 |
|
| 2019 |
Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, ... ... Shorter J, et al. Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity. Cell Reports. 28: 2080-2095.e6. PMID 31433984 DOI: 10.1016/J.Celrep.2019.07.069 |
0.818 |
|
| 2019 |
Ryan JJ, Sprunger ML, Holthaus K, Shorter J, Jackrel ME. Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma. The Journal of Biological Chemistry. PMID 31171724 DOI: 10.1074/Jbc.Ra119.009494 |
0.842 |
|
| 2019 |
Rizo AN, Lin J, Gates SN, Tse E, Bart SM, Castellano LM, DiMaio F, Shorter J, Southworth DR. Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase. Nature Communications. 10: 2393. PMID 31160557 DOI: 10.1038/S41467-019-10150-Y |
0.821 |
|
| 2019 |
Durie CL, Lin J, Scull NW, Mack KL, Jackrel ME, Sweeny EA, Castellano LM, Shorter J, Lucius AL. Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases. Biophysical Journal. PMID 31027887 DOI: 10.1016/J.Bpj.2019.03.035 |
0.833 |
|
| 2019 |
March ZM, Mack KL, Shorter J. AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease. Biophysical Journal. PMID 30952364 DOI: 10.1016/J.Bpj.2019.03.007 |
0.834 |
|
| 2019 |
Shorter J. Phase separation of RNA-binding proteins in physiology and disease: An introduction to the JBC Reviews thematic series. The Journal of Biological Chemistry. PMID 30948513 DOI: 10.1074/Jbc.Rev119.007944 |
0.409 |
|
| 2019 |
Ye X, Lin J, Mayne L, Shorter J, Englander SW. Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution. Proceedings of the National Academy of Sciences of the United States of America. PMID 30918129 DOI: 10.1073/Pnas.1816184116 |
0.784 |
|
| 2019 |
Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. PMID 30853299 DOI: 10.1016/J.Neuron.2019.02.038 |
0.477 |
|
| 2019 |
Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, ... ... Shorter J, et al. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron. PMID 30826182 DOI: 10.1016/J.Neuron.2019.01.048 |
0.806 |
|
| 2019 |
Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, ... ... Shorter J, et al. Heterochromatin anomalies and double-stranded RNA accumulation underlie poly(PR) toxicity. Science (New York, N.Y.). 363. PMID 30765536 DOI: 10.1126/Science.Aav2606 |
0.503 |
|
| 2019 |
Shorter J, Southworth DR. Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase. Cold Spring Harbor Perspectives in Biology. PMID 30745294 DOI: 10.1101/Cshperspect.A034033 |
0.47 |
|
| 2019 |
Guo L, Fare CM, Shorter J. Therapeutic Dissolution of Aberrant Phases by Nuclear-Import Receptors. Trends in Cell Biology. PMID 30660504 DOI: 10.1016/J.Tcb.2018.12.004 |
0.818 |
|
| 2019 |
Barbieri EM, Shorter J. TDP-43 shapeshifts to encipher FTD severity. Nature Neuroscience. 22: 3-5. PMID 30559481 DOI: 10.1038/S41593-018-0299-6 |
0.624 |
|
| 2019 |
Ye X, Lin J, Mayne LC, Shorter J, Englander SW. Mechanism of Hsp104 Function Potentiation Studied by Hydrogen-Deuterium Exchange Detected by Mass Spectrometry (HX-Ms) Biophysical Journal. 116: 484a. DOI: 10.1016/J.Bpj.2018.11.2612 |
0.719 |
|
| 2018 |
Michalska K, Zhang K, March ZM, Hatzos-Skintges C, Pintilie G, Bigelow L, Castellano LM, Miles LJ, Jackrel ME, Chuang E, Jedrzejczak R, Shorter J, Chiu W, Joachimiak A. Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events. Structure (London, England : 1993). PMID 30595457 DOI: 10.1016/J.Str.2018.11.001 |
0.829 |
|
| 2018 |
McGurk L, Gomes E, Guo L, Shorter J, Bonini N. Poly(ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation. Biochemistry. PMID 30540446 DOI: 10.1021/Acs.Biochem.8B00910 |
0.687 |
|
| 2018 |
Portz B, Shorter J. 3' UTRs in the Eye of the TIGER. Developmental Cell. 47: 544-546. PMID 30513300 DOI: 10.1016/J.Devcel.2018.11.022 |
0.781 |
|
| 2018 |
Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, et al. TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature. 563: 508-513. PMID 30464263 DOI: 10.1038/S41586-018-0665-2 |
0.436 |
|
| 2018 |
Shorter J, Houry WA. Editorial: The Role of AAA+ Proteins in Protein Repair and Degradation. Frontiers in Molecular Biosciences. 5: 85. PMID 30333982 DOI: 10.3389/Fmolb.2018.00085 |
0.373 |
|
| 2018 |
McGurk L, Mojsilovic-Petrovic J, Van Deerlin VM, Shorter J, Kalb RG, Lee VM, Trojanowski JQ, Lee EB, Bonini NM. Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 6: 84. PMID 30157956 DOI: 10.1186/S40478-018-0586-1 |
0.604 |
|
| 2018 |
McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM. Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization. Molecular Cell. PMID 30100264 DOI: 10.1016/J.Molcel.2018.07.002 |
0.651 |
|
| 2018 |
Gomes E, Shorter J. The molecular language of membraneless organelles. The Journal of Biological Chemistry. PMID 30045872 DOI: 10.1074/Jbc.Tm118.001192 |
0.303 |
|
| 2018 |
Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, et al. Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity. Cell Reports. 24: 529-537.e4. PMID 30021151 DOI: 10.1016/J.Celrep.2018.06.070 |
0.559 |
|
| 2018 |
Tariq A, Lin J, Noll MM, Torrente MP, Mack KL, Murillo OH, Jackrel ME, Shorter J. Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain. Fems Yeast Research. 18. PMID 29788207 DOI: 10.1093/Femsyr/Foy042 |
0.82 |
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| 2018 |
Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, ... ... Shorter J, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173: 677-692.e20. PMID 29677512 DOI: 10.1016/J.Cell.2018.03.002 |
0.816 |
|
| 2018 |
Chuang E, Hori AM, Hesketh CD, Shorter J. Amyloid assembly and disassembly. Journal of Cell Science. 131. PMID 29654159 DOI: 10.1242/Jcs.189928 |
0.687 |
|
| 2018 |
Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M. Protein Phase Separation: A New Phase in Cell Biology. Trends in Cell Biology. PMID 29602697 DOI: 10.1016/J.Tcb.2018.02.004 |
0.379 |
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| 2018 |
Subudhi I, Shorter J. Ubiquilin 2: Shuttling Clients Out of Phase? Molecular Cell. 69: 919-921. PMID 29547719 DOI: 10.1016/J.Molcel.2018.02.030 |
0.367 |
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| 2018 |
Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, ... ... Shorter J, et al. FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Molecular Cell. 69: 787-801.e8. PMID 29499134 DOI: 10.1016/J.Molcel.2018.02.001 |
0.479 |
|
| 2018 |
Cupo RR, Augustine E, Shorter J. Exploring and Enhancing Compartment-Specific Protein Disaggregases to Combat Neurodegenerative Diseases Biophysical Journal. 114: 578a-579a. DOI: 10.1016/J.Bpj.2017.11.3165 |
0.822 |
|
| 2018 |
Weaver CL, Jackrel ME, Lin J, Mack KL, Sweeny E, Duran EC, Shorter J, Lucius AL. Kinetic Mechanism of ATP-Dependent Disaggregating Motor Saccharomyces cerevisiae Hsp104 Biophysical Journal. 114: 553a. DOI: 10.1016/J.Bpj.2017.11.3021 |
0.782 |
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| 2017 |
Shorter J. Liquidizing FUS via prion-like domain phosphorylation. The Embo Journal. PMID 28963393 DOI: 10.15252/Embj.201798078 |
0.39 |
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| 2017 |
Shorter J. Prion-like Domains Program Ewing's Sarcoma. Cell. 171: 30-31. PMID 28938120 DOI: 10.1016/J.Cell.2017.09.010 |
0.366 |
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| 2017 |
Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science (New York, N.Y.). PMID 28619716 DOI: 10.1126/Science.Aan1052 |
0.816 |
|
| 2017 |
Gitler AD, Dhillon P, Shorter J. Neurodegenerative disease: models, mechanisms, and a new hope. Disease Models & Mechanisms. 10: 499-502. PMID 28468935 DOI: 10.1242/Dmm.030205 |
0.577 |
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| 2017 |
Harrison AF, Shorter J. RNA-binding proteins with prion-like domains in health and disease. The Biochemical Journal. 474: 1417-1438. PMID 28389532 DOI: 10.1042/Bcj20160499 |
0.489 |
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| 2017 |
Weaver CL, Duran EC, Mack KL, Lin J, Jackrel ME, Sweeny EA, Shorter J, Lucius AL. Avidity for polypeptide binding by nucleotide-bound Hsp104 structures. Biochemistry. PMID 28379007 DOI: 10.1021/Acs.Biochem.7B00225 |
0.806 |
|
| 2017 |
Yasuda K, Clatterbuck-Soper SF, Jackrel ME, Shorter J, Mili S. FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination. The Journal of Cell Biology. PMID 28298410 DOI: 10.1083/Jcb.201608022 |
0.73 |
|
| 2017 |
Jackrel ME, Shorter J. Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease. Frontiers in Neuroscience. 11: 99. PMID 28293166 DOI: 10.3389/Fnins.2017.00099 |
0.776 |
|
| 2017 |
Shorter J. Designer protein disaggregases to counter neurodegenerative disease. Current Opinion in Genetics & Development. 44: 1-8. PMID 28208059 DOI: 10.1016/J.Gde.2017.01.008 |
0.5 |
|
| 2017 |
Shorter J. Susan Lee Lindquist (1949–2016) Trends in Biochemical Sciences. 42: 169-170. DOI: 10.1016/J.Tibs.2016.12.002 |
0.387 |
|
| 2016 |
Guo L, Shorter J. Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies. Cold Spring Harbor Perspectives in Medicine. PMID 27920024 DOI: 10.1101/Cshperspect.A024554 |
0.596 |
|
| 2016 |
Shorter J, Gitler AD. Susan Lee Lindquist (1949-2016). Nature. 540: 40. PMID 27905439 DOI: 10.1038/540040A |
0.494 |
|
| 2016 |
Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR. Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nature Structural & Molecular Biology. PMID 27478928 DOI: 10.1038/Nsmb.3277 |
0.831 |
|
| 2016 |
Shorter J. Engineering therapeutic protein disaggregases. Molecular Biology of the Cell. 27: 1556-60. PMID 27255695 DOI: 10.1091/Mbc.E15-10-0693 |
0.484 |
|
| 2016 |
Shorter J. Membraneless organelles: Phasing in and out. Nature Chemistry. 8: 528-30. PMID 27219695 DOI: 10.1038/Nchem.2534 |
0.303 |
|
| 2016 |
Mack KL, Shorter J. Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity. Frontiers in Molecular Biosciences. 3: 8. PMID 27014702 DOI: 10.3389/Fmolb.2016.00008 |
0.825 |
|
| 2016 |
March ZM, King OD, Shorter J. Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease. Brain Research. PMID 26996412 DOI: 10.1016/J.Brainres.2016.02.037 |
0.831 |
|
| 2016 |
Torrente MP, Chuang E, Noll MM, Jackrel ME, Go MS, Shorter J. Mechanistic Insights Into Hsp104 Potentiation. The Journal of Biological Chemistry. PMID 26747608 DOI: 10.1074/Jbc.M115.707976 |
0.836 |
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| 2016 |
Sweeny EA, Shorter J. Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104. Journal of Molecular Biology. 428: 1870-85. PMID 26608812 DOI: 10.1016/J.Jmb.2015.11.016 |
0.785 |
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| 2016 |
Shorter J. Engineering therapeutic protein disaggregases Molecular Biology of the Cell. 27: 1556-1560. DOI: 10.1091/mbc.E15-10-0693 |
0.381 |
|
| 2016 |
Sweeny EA, Shorter J. Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104 Journal of Molecular Biology. 428: 1870-1885. DOI: 10.1016/j.jmb.2015.11.016 |
0.768 |
|
| 2015 |
Guo L, Shorter J. It's Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles. Molecular Cell. 60: 189-92. PMID 26474062 DOI: 10.1016/J.Molcel.2015.10.006 |
0.464 |
|
| 2015 |
Lindberg I, Shorter J, Wiseman RL, Chiti F, Dickey CA, McLean PJ. Chaperones in Neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13853-9. PMID 26468185 DOI: 10.1523/Jneurosci.2600-15.2015 |
0.439 |
|
| 2015 |
Ford AF, Shorter J. Fleeting Amyloid-like Forms of Rim4 Ensure Meiotic Fidelity. Cell. 163: 275-6. PMID 26451477 DOI: 10.1016/J.Cell.2015.09.049 |
0.822 |
|
| 2015 |
Jackrel ME, Yee K, Tariq A, Chen AI, Shorter J. Disparate Mutations Confer Therapeutic Gain of Hsp104 Function. Acs Chemical Biology. PMID 26441009 DOI: 10.1021/Acschembio.5B00765 |
0.759 |
|
| 2015 |
Castellano LM, Hammond RM, Holmes VM, Weissman D, Shorter J. Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils. Biology Open. 4: 1206-12. PMID 26319581 DOI: 10.1242/Bio.010215 |
0.69 |
|
| 2015 |
Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, ... ... Shorter J, et al. A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife. 4. PMID 26284498 DOI: 10.7554/Elife.05397 |
0.687 |
|
| 2015 |
Castellano LM, Bart SM, Holmes VM, Weissman D, Shorter J. Repurposing Hsp104 to Antagonize Seminal Amyloid and Counter HIV Infection. Chemistry & Biology. 22: 1074-86. PMID 26256479 DOI: 10.1016/J.Chembiol.2015.07.007 |
0.72 |
|
| 2015 |
Jackrel ME, Shorter J. Engineering enhanced protein disaggregases for neurodegenerative disease. Prion. 9: 90-109. PMID 25738979 DOI: 10.1080/19336896.2015.1020277 |
0.793 |
|
| 2015 |
Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J. The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Molecular Cell. 57: 836-49. PMID 25620563 DOI: 10.1016/J.Molcel.2014.12.021 |
0.828 |
|
| 2015 |
Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, Von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, ... ... Shorter J, et al. A molecular tweezer antagonizes seminal amyloids and HIV infection Elife. 4. DOI: 10.7554/eLife.05397 |
0.646 |
|
| 2014 |
Jackrel ME, Tariq A, Yee K, Weitzman R, Shorter J. Isolating potentiated Hsp104 variants using yeast proteinopathy models. Journal of Visualized Experiments : Jove. e52089. PMID 25407485 DOI: 10.3791/52089 |
0.78 |
|
| 2014 |
Torrente MP, Castellano LM, Shorter J. Suramin inhibits Hsp104 ATPase and disaggregase activity Plos One. 9. PMID 25299406 DOI: 10.1371/Journal.Pone.0110115 |
0.828 |
|
| 2014 |
Seither KM, McMahon HA, Singh N, Wang H, Cushman-Nick M, Montalvo GL, DeGrado WF, Shorter J. Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly. The Biochemical Journal. 464: 85-98. PMID 25142005 DOI: 10.1042/Bj20131609 |
0.802 |
|
| 2014 |
Jackrel ME, Shorter J. Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins. Disease Models & Mechanisms. 7: 1175-84. PMID 25062688 DOI: 10.1242/Dmm.016113 |
0.797 |
|
| 2014 |
Guo L, Giasson BI, Glavis-Bloom A, Brewer MD, Shorter J, Gitler AD, Yang X. A cellular system that degrades misfolded proteins and protects against neurodegeneration. Molecular Cell. 55: 15-30. PMID 24882209 DOI: 10.1016/J.Molcel.2014.04.030 |
0.713 |
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| 2014 |
Jackrel ME, Shorter J. Reversing deleterious protein aggregation with re-engineered protein disaggregases. Cell Cycle (Georgetown, Tex.). 13: 1379-83. PMID 24694655 DOI: 10.4161/Cc.28709 |
0.772 |
|
| 2014 |
Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, et al. ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. The Journal of Clinical Investigation. 124: 981-99. PMID 24509083 DOI: 10.1172/Jci72723 |
0.336 |
|
| 2014 |
Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J. Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 156: 170-82. PMID 24439375 DOI: 10.1016/J.Cell.2013.11.047 |
0.847 |
|
| 2014 |
Desantis ME, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. The Journal of Biological Chemistry. 289: 848-67. PMID 24280225 DOI: 10.1074/Jbc.M113.520759 |
0.84 |
|
| 2013 |
Torrente MP, Shorter J. The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins Prion. 7: 457-463. PMID 24401655 DOI: 10.4161/Pri.27531 |
0.82 |
|
| 2013 |
Cushman-Nick M, Bonini NM, Shorter J. Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model. Plos Genetics. 9: e1003781. PMID 24039611 DOI: 10.1371/Journal.Pgen.1003781 |
0.835 |
|
| 2013 |
Coelho M, Dereli A, Haese A, Kühn S, Malinovska L, DeSantis ME, Shorter J, Alberti S, Gross T, Tolić-Nørrelykke IM. Fission yeast does not age under favorable conditions, but does so after stress. Current Biology : Cb. 23: 1844-52. PMID 24035542 DOI: 10.1016/J.Cub.2013.07.084 |
0.68 |
|
| 2013 |
Li YR, King OD, Shorter J, Gitler AD. Stress granules as crucibles of ALS pathogenesis. The Journal of Cell Biology. 201: 361-72. PMID 23629963 DOI: 10.1083/Jcb.201302044 |
0.668 |
|
| 2013 |
Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, ... ... Shorter J, et al. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature. 495: 467-73. PMID 23455423 DOI: 10.1038/Nature11922 |
0.821 |
|
| 2013 |
Weihl C, Benatar M, Kimonis V, Shorter J, Taylor J. P.14.12 Mutations in prion domains of RNA binding proteins hnRNPA2/B and A1 cause IBM associated with Paget’s disease, dementia and ALS Neuromuscular Disorders. 23: 817. DOI: 10.1016/J.Nmd.2013.06.620 |
0.435 |
|
| 2013 |
DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J. Inter-Subunit Coordination in Hsp104, a Protein Disaggregase Biophysical Journal. 104: 571a. DOI: 10.1016/J.Bpj.2012.11.3173 |
0.813 |
|
| 2013 |
Jackrel ME, DeSantis ME, Castellano LM, Shorter J. Potentiated Hsp104 Variants Antagonize Diverse Protein Misfolding Events Biophysical Journal. 104: 570a. DOI: 10.1016/j.bpj.2012.11.3167 |
0.82 |
|
| 2013 |
Sweeny EA, Gupta K, Shorter J. Conformational Changes of Hsp104 Revealed through Small Angle X-Ray Scattering (SAXS) Biophysical Journal. 104: 182a. DOI: 10.1016/J.Bpj.2012.11.1026 |
0.793 |
|
| 2012 |
Castellano LM, Shorter J. The Surprising Role of Amyloid Fibrils in HIV Infection. Biology. 1: 58-80. PMID 24832047 DOI: 10.3390/Biology1010058 |
0.682 |
|
| 2012 |
Desantis ME, Shorter J. Hsp104 drives "protein-only" positive selection of sup35 prion strains encoding strong [PSI+] Chemistry and Biology. 19: 1400-1410. PMID 23177195 DOI: 10.1016/J.Chembiol.2012.09.013 |
0.724 |
|
| 2012 |
DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J. Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. Cell. 151: 778-93. PMID 23141537 DOI: 10.1016/J.Cell.2012.09.038 |
0.817 |
|
| 2012 |
Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nature Genetics. 44: 1302-9. PMID 23104007 DOI: 10.1038/Ng.2434 |
0.629 |
|
| 2012 |
Ugras SE, Shorter J. RNA-Binding Proteins in Amyotrophic Lateral Sclerosis and Neurodegeneration. Neurology Research International. 2012: 432780. PMID 22919483 DOI: 10.1155/2012/432780 |
0.418 |
|
| 2012 |
Duennwald ML, Echeverria A, Shorter J. Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans. Plos Biology. 10: e1001346. PMID 22723742 DOI: 10.1371/Journal.Pbio.1001346 |
0.757 |
|
| 2012 |
Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, ... ... Shorter J, et al. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics. 21: 2899-911. PMID 22454397 DOI: 10.1093/Hmg/Dds116 |
0.746 |
|
| 2012 |
King OD, Gitler AD, Shorter J. The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Research. 1462: 61-80. PMID 22445064 DOI: 10.1016/J.Brainres.2012.01.016 |
0.668 |
|
| 2012 |
DeSantis ME, Shorter J. The elusive middle domain of Hsp104 and ClpB: Location and function Biochimica Et Biophysica Acta - Molecular Cell Research. 1823: 29-39. PMID 21843558 DOI: 10.1016/J.Bbamcr.2011.07.014 |
0.78 |
|
| 2012 |
Castellano LM, Shorter J. The surprising role of amyloid fibrils in HIV infection Biology. 1: 58-80. DOI: 10.3390/biology1010058 |
0.658 |
|
| 2012 |
Ugras SE, Shorter J. RNA-binding proteins in amyotrophic lateral sclerosis and neurodegeneration Neurology Research International. 2012. DOI: 10.1155/2012/432780 |
0.301 |
|
| 2012 |
Shorter J. Operational Plasticity of Hsp104, a Prion Disaggregase Biophysical Journal. 102: 60a. DOI: 10.1016/J.Bpj.2011.11.356 |
0.461 |
|
| 2011 |
Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, et al. A yeast functional screen predicts new candidate ALS disease genes. Proceedings of the National Academy of Sciences of the United States of America. 108: 20881-90. PMID 22065782 DOI: 10.1073/Pnas.1109434108 |
0.732 |
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| 2011 |
Shorter J. The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system. Plos One. 6: e26319. PMID 22022600 DOI: 10.1371/Journal.Pone.0026319 |
0.498 |
|
| 2011 |
Sweeny EA, DeSantis ME, Shorter J. Purification of hsp104, a protein disaggregase Journal of Visualized Experiments : Jove. PMID 21989490 DOI: 10.3791/3190 |
0.853 |
|
| 2011 |
Gitler AD, Shorter J. RNA-binding proteins with prion-like domains in ALS and FTLD-U. Prion. 5: 179-87. PMID 21847013 DOI: 10.4161/Pri.5.3.17230 |
0.679 |
|
| 2011 |
Jackrel ME, Shorter J. Shock and awe: unleashing the heat shock response to treat Huntington disease. The Journal of Clinical Investigation. 121: 2972-5. PMID 21785212 DOI: 10.1172/Jci59190 |
0.763 |
|
| 2011 |
Sun Z, Diaz Z, Fang X, Hart MP, Chesi A, Shorter J, Gitler AD. Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. Plos Biology. 9: e1000614. PMID 21541367 DOI: 10.1371/Journal.Pbio.1000614 |
0.673 |
|
| 2011 |
Shorter J. The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system Plos One. 6. DOI: 10.1371/journal.pone.0026319 |
0.399 |
|
| 2010 |
Duennwald ML, Shorter J. Countering amyloid polymorphism and drug resistance with minimal drug cocktails. Prion. 4: 244-51. PMID 20935457 DOI: 10.4161/Pri.4.4.13597 |
0.708 |
|
| 2010 |
Shorter J. Emergence and natural selection of drug-resistant prions Molecular Biosystems. 6: 1115-1130. PMID 20422111 DOI: 10.1039/C004550K |
0.348 |
|
| 2010 |
Cushman M, Johnson BS, King OD, Gitler AD, Shorter J. Prion-like disorders: blurring the divide between transmissibility and infectivity. Journal of Cell Science. 123: 1191-201. PMID 20356930 DOI: 10.1242/Jcs.051672 |
0.671 |
|
| 2010 |
Vashist S, Cushman M, Shorter J. Applying Hsp104 to protein-misfolding disorders Biochemistry and Cell Biology. 88: 1-13. PMID 20130674 DOI: 10.1139/O09-121 |
0.849 |
|
| 2009 |
Roberts BE, Duennwald ML, Wang H, Chung C, Lopreiato NP, Sweeny EA, Knight MN, Shorter J. A synergistic small-molecule combination directly eradicates diverse prion strain structures. Nature Chemical Biology. 5: 936-46. PMID 19915541 DOI: 10.1038/Nchembio.246 |
0.784 |
|
| 2009 |
Watt B, van Niel G, Fowler DM, Hurbain I, Luk KC, Stayrook SE, Lemmon MA, Raposo G, Shorter J, Kelly JW, Marks MS. N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. The Journal of Biological Chemistry. 284: 35543-55. PMID 19840945 DOI: 10.1074/Jbc.M109.047449 |
0.388 |
|
| 2009 |
Johnson BS, Snead D, Lee JJ, McCaffery JM, Shorter J, Gitler AD. TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. The Journal of Biological Chemistry. 284: 20329-39. PMID 19465477 DOI: 10.1074/Jbc.M109.010264 |
0.637 |
|
| 2009 |
Wendler P, Shorter J, Snead D, Plisson C, Clare DK, Lindquist S, Saibil HR. Motor Mechanism for Protein Threading through Hsp104 Molecular Cell. 34: 81-92. PMID 19362537 DOI: 10.1016/J.Molcel.2009.02.026 |
0.617 |
|
| 2008 |
Sweeny EA, Shorter J. Prion proteostasis: Hsp104 meets its supporting cast Prion. 2: 135-140. PMID 19242125 DOI: 10.4161/Pri.2.4.7952 |
0.786 |
|
| 2008 |
Skinner JJ, Wood S, Shorter J, Englander SW, Black BE. The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching. The Journal of Cell Biology. 183: 761-8. PMID 19029339 DOI: 10.1083/Jcb.200808122 |
0.32 |
|
| 2008 |
Shorter J, Lindquist S. Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions Embo Journal. 27: 2712-2724. PMID 18833196 DOI: 10.1038/Emboj.2008.194 |
0.603 |
|
| 2008 |
Maday S, Anderson E, Chang HC, Shorter J, Satoh A, Sfakianos J, Fölsch H, Anderson JM, Walther Z, Mellman I. A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells. Traffic (Copenhagen, Denmark). 9: 1915-24. PMID 18764819 DOI: 10.1111/J.1600-0854.2008.00805.X |
0.331 |
|
| 2008 |
Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. The Journal of Clinical Investigation. 118: 3087-97. PMID 18704197 DOI: 10.1172/Jci35781 |
0.576 |
|
| 2008 |
Roberts BE, Shorter J. Escaping amyloid fate Nature Structural and Molecular Biology. 15: 544-546. PMID 18523464 DOI: 10.1038/Nsmb0608-544 |
0.344 |
|
| 2008 |
Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, Steele AD, Krishnan R, Su LJ, Griffin D, Mukhopadhyay S, Hennessy EJ, Weigele P, Blanchard BJ, King J, Deniz AA, ... ... Shorter J, et al. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proceedings of the National Academy of Sciences of the United States of America. 105: 7159-64. PMID 18480256 DOI: 10.1073/Pnas.0801934105 |
0.804 |
|
| 2008 |
Sadlish H, Rampelt H, Shorter J, Wegrzyn RD, Andréasson C, Lindquist S, Bukau B. Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities. Plos One. 3: e1763. PMID 18335038 DOI: 10.1371/Journal.Pone.0001763 |
0.603 |
|
| 2008 |
Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 105: 145-50. PMID 18162536 DOI: 10.1073/Pnas.0710685105 |
0.651 |
|
| 2007 |
Wendler P, Shorter J, Plisson C, Cashikar AG, Lindquist S, Saibil HR. Atypical AAA+ Subunit Packing Creates an Expanded Cavity for Disaggregation by the Protein-Remodeling Factor Hsp104 Cell. 131: 1366-1377. PMID 18160044 DOI: 10.1016/J.Cell.2007.10.047 |
0.625 |
|
| 2007 |
Shorter J. Hsp104: A weapon to combat diverse neurodegenerative disorders Neurosignals. 16: 63-74. PMID 18097161 DOI: 10.1159/000109760 |
0.515 |
|
| 2007 |
Gitler AD, Shorter J. Prime time for alpha-synuclein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2433-4. PMID 17344380 DOI: 10.1523/Jneurosci.0094-07.2007 |
0.506 |
|
| 2007 |
Doyle SM, Shorter J, Zolkiewski M, Hoskins JR, Lindquist S, Wickner S. Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity Nature Structural and Molecular Biology. 14: 114-122. PMID 17259993 DOI: 10.1038/Nsmb1198 |
0.644 |
|
| 2006 |
Shorter J, Lindquist S. Destruction or Potentiation of Different Prions Catalyzed by Similar Hsp104 Remodeling Activities Molecular Cell. 23: 425-438. PMID 16885031 DOI: 10.1016/J.Molcel.2006.05.042 |
0.62 |
|
| 2005 |
Shorter J, Lindquist S. Prions as adaptive conduits of memory and inheritance Nature Reviews Genetics. 6: 435-450. PMID 15931169 DOI: 10.1038/Nrg1616 |
0.516 |
|
| 2005 |
Beard M, Satoh A, Shorter J, Warren G. A cryptic Rab1-binding site in the p115 tethering protein. The Journal of Biological Chemistry. 280: 25840-8. PMID 15878873 DOI: 10.1074/Jbc.M503925200 |
0.555 |
|
| 2005 |
Shorter J, Lindquist S. Navigating the CIpB channel to solution Nature Structural and Molecular Biology. 12: 4-6. PMID 15689967 DOI: 10.1038/Nsmb0105-4 |
0.578 |
|
| 2004 |
Shorter J, Lindquist S. Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers Science. 304: 1793-1797. PMID 15155912 DOI: 10.1126/Science.1098007 |
0.6 |
|
| 2003 |
Wang Y, Seemann J, Pypaert M, Shorter J, Warren G. A direct role for GRASP65 as a mitotically regulated Golgi stacking factor. The Embo Journal. 22: 3279-90. PMID 12839990 DOI: 10.1093/Emboj/Cdg317 |
0.685 |
|
| 2003 |
Wang Y, Seemann J, Pypaert M, Shorter J, Warren G. Erratum: A direct role for GRASP65 as a mitotically regulated golgi stacking factor (EMBO Journal (22) (3279-3290)) The Embo Journal. 22. DOI: 10.1093/Emboj/Cdg422 |
0.648 |
|
| 2002 |
Shorter J, Warren G. Golgi architecture and inheritance Annual Review of Cell and Developmental Biology. 18: 379-420. PMID 12142281 DOI: 10.1146/Annurev.Cellbio.18.030602.133733 |
0.525 |
|
| 2002 |
Muller JM, Shorter J, Newman R, Deinhardt K, Sagiv Y, Elazar Z, Warren G, Shima DT. Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. The Journal of Cell Biology. 157: 1161-73. PMID 12070132 DOI: 10.1083/Jcb.200202082 |
0.543 |
|
| 2002 |
Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G. Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. The Journal of Cell Biology. 157: 45-62. PMID 11927603 DOI: 10.1083/Jcb.200112127 |
0.518 |
|
| 2000 |
Dirac-Svejstrup AB, Shorter J, Waters MG, Warren G. Phosphorylation of the vesicle-tethering protein p115 by a casein kinase II-like enzyme is required for Golgi reassembly from isolated mitotic fragments. The Journal of Cell Biology. 150: 475-88. PMID 10931861 DOI: 10.1083/Jcb.150.3.475 |
0.547 |
|
| 2000 |
Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. The Embo Journal. 19: 2181-92. PMID 10811609 DOI: 10.1093/Emboj/19.10.2181 |
0.488 |
|
| 2000 |
Lesa GM, Seemann J, Shorter J, Vandekerckhove J, Warren G. The amino-terminal domain of the golgi protein giantin interacts directly with the vesicle-tethering protein p115. The Journal of Biological Chemistry. 275: 2831-6. PMID 10644749 DOI: 10.1074/Jbc.275.4.2831 |
0.571 |
|
| 1999 |
Müller JM, Rabouille C, Newman R, Shorter J, Freemont P, Schiavo G, Warren G, Shima DT. An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion. Nature Cell Biology. 1: 335-40. PMID 10559959 DOI: 10.1038/14025 |
0.535 |
|
| 1999 |
Shorter J, Watson R, Giannakou ME, Clarke M, Warren G, Barr FA. GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system. The Embo Journal. 18: 4949-60. PMID 10487747 DOI: 10.1093/Emboj/18.18.4949 |
0.593 |
|
| 1999 |
Shorter J, Warren G. A role for the vesicle tethering protein, p115, in the post-mitotic stacking of reassembling Golgi cisternae in a cell-free system Journal of Cell Biology. 146: 57-70. PMID 10402460 DOI: 10.1083/Jcb.146.1.57 |
0.529 |
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