| Year |
Citation |
Score |
| 2020 |
Pabona JMP, Burnett AF, Brown DM, Quick CM, Simmen FA, Montales MTE, Liu SJ, Rose T, Alhallak I, Siegel ER, Simmen RC. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reproductive Sciences (Thousand Oaks, Calif.). PMID 32046384 DOI: 10.1007/S43032-019-00019-2 |
0.423 |
|
| 2018 |
Saguyod SJU, Kelley AS, Velarde MC, Simmen RC. Diet and endometriosis-revisiting the linkages to inflammation Journal of Endometriosis and Pelvic Pain Disorders. 10: 51-58. DOI: 10.1177/2284026518769022 |
0.63 |
|
| 2016 |
Simmen RC, Kelley AS. Reversal of fortune: estrogen receptor-beta in endometriosis. Journal of Molecular Endocrinology. PMID 27272520 DOI: 10.1530/JME-16-0080 |
0.331 |
|
| 2016 |
Heard ME, Melnyk SB, Simmen FA, Yang Y, Pabona JM, Simmen RC. High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated with Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status. Endocrinology. en20161092. PMID 27175969 DOI: 10.1210/En.2016-1092 |
0.781 |
|
| 2015 |
Brown AR, Simmen RC, Raj VR, Van TT, MacLeod SL, Simmen FA. Krüppel-like Factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling. Carcinogenesis. PMID 26210742 DOI: 10.1093/Carcin/Bgv104 |
0.31 |
|
| 2015 |
Heard ME, Velarde MC, Giudice LC, Simmen FA, Simmen RC. Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis. Biology of Reproduction. 92: 140. PMID 25904015 DOI: 10.1095/Biolreprod.115.130260 |
0.793 |
|
| 2015 |
Simmen RC, Heard ME, Simmen AM, Montales MT, Marji M, Scanlon S, Pabona JM. The Krüppel-like factors in female reproductive system pathologies. Journal of Molecular Endocrinology. 54: R89-R101. PMID 25654975 DOI: 10.1530/Jme-14-0310 |
0.792 |
|
| 2014 |
Montales MT, Melnyk SB, Simmen FA, Simmen RC. Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes. Carcinogenesis. 35: 2102-12. PMID 24832086 DOI: 10.1093/Carcin/Bgu106 |
0.311 |
|
| 2014 |
Heard ME, Simmons CD, Simmen FA, Simmen RC. Krüppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis. Endocrinology. 155: 1532-46. PMID 24476135 DOI: 10.1210/En.2013-1947 |
0.785 |
|
| 2013 |
Rahal OM, Machado HL, Montales MT, Pabona JM, Heard ME, Nagarajan S, Simmen RC. Dietary suppression of the mammary CD29(hi)CD24(+) epithelial subpopulation and its cytokine/chemokine transcriptional signatures modifies mammary tumor risk in MMTV-Wnt1 transgenic mice. Stem Cell Research. 11: 1149-62. PMID 24012543 DOI: 10.1016/J.Scr.2013.08.006 |
0.762 |
|
| 2013 |
Montales MT, Rahal OM, Nakatani H, Matsuda T, Simmen RC. Repression of mammary adipogenesis by genistein limits mammosphere formation of human MCF-7 cells. The Journal of Endocrinology. 218: 135-49. PMID 23645249 DOI: 10.1530/Joe-12-0520 |
0.781 |
|
| 2013 |
Meyer M, Kesic MJ, Clarke J, Ho E, Simmen RC, Diaz-Sanchez D, Noah TL, Jaspers I. Sulforaphane induces SLPI secretion in the nasal mucosa. Respiratory Medicine. 107: 472-5. PMID 23195333 DOI: 10.1016/J.Rmed.2012.11.006 |
0.304 |
|
| 2013 |
Rahal OM, Pabona JM, Kelly T, Huang Y, Hennings LJ, Prior RL, Al-Dwairi A, Simmen FA, Simmen RC. Suppression of Wnt1-induced mammary tumor growth and lower serum insulin in offspring exposed to maternal blueberry diet suggest early dietary influence on developmental programming. Carcinogenesis. 34: 464-74. PMID 23144318 DOI: 10.1093/Carcin/Bgs353 |
0.745 |
|
| 2013 |
Pabona JM, Dave B, Su Y, Montales MT, de Lumen BO, de Mejia EG, Rahal OM, Simmen RC. The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein. Genes & Nutrition. 8: 79-90. PMID 22864686 DOI: 10.1007/S12263-012-0307-5 |
0.765 |
|
| 2012 |
Heard ME, Pabona JM, Clayberger C, Krensky AM, Simmen FA, Simmen RC. The reproductive phenotype of mice null for transcription factor Krüppel-like factor 13 suggests compensatory function of family member Krüppel-like factor 9 in the peri-implantation uterus. Biology of Reproduction. 87: 115. PMID 22993382 DOI: 10.1095/Biolreprod.112.102251 |
0.812 |
|
| 2012 |
Pabona JM, Simmen FA, Nikiforov MA, Zhuang D, Shankar K, Velarde MC, Zelenko Z, Giudice LC, Simmen RC. Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis. The Journal of Clinical Endocrinology and Metabolism. 97: E376-92. PMID 22259059 DOI: 10.1210/Jc.2011-2562 |
0.757 |
|
| 2012 |
Montales MT, Rahal OM, Kang J, Rogers TJ, Prior RL, Wu X, Simmen RC. Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells. Carcinogenesis. 33: 652-60. PMID 22219179 DOI: 10.1093/Carcin/Bgr317 |
0.766 |
|
| 2011 |
Rahal OM, Simmen RC. Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen receptor β signaling. Endocrinology. 152: 3409-21. PMID 21712365 DOI: 10.1210/En.2011-1085 |
0.783 |
|
| 2011 |
Simmons CD, Pabona JM, Heard ME, Friedman TM, Spataro MT, Godley AL, Simmen FA, Burnett AF, Simmen RC. Krüppel-like factor 9 loss-of-expression in human endometrial carcinoma links altered expression of growth-regulatory genes with aberrant proliferative response to estrogen. Biology of Reproduction. 85: 378-85. PMID 21543766 DOI: 10.1095/Biolreprod.110.090654 |
0.809 |
|
| 2011 |
Su Y, Shankar K, Rahal O, Simmen RC. Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer--preventive actions of dietary factors. The Journal of Nutritional Biochemistry. 22: 605-11. PMID 21292471 DOI: 10.1016/J.Jnutbio.2010.09.008 |
0.772 |
|
| 2011 |
Brown AR, Simmen RC, Simmen FA. Abstract A44: Suppression of insulin-induced fatty acid synthase gene expression and colon cancer cell proliferation by members of the Krüppel-like family of transcription factors Cancer Prevention Research. 4. DOI: 10.1158/1940-6207.Prev-11-A44 |
0.426 |
|
| 2011 |
Al-Dwairi A, Brown AR, Simmen RC, Simmen FA. Abstract 4072: Insulin and NADPH-generating enzymes as molecular targets to repress colon cancer cell proliferation Cancer Research. 71: 4072-4072. DOI: 10.1158/1538-7445.Am2011-4072 |
0.361 |
|
| 2011 |
Heard M, Pabona JM, Clayberger C, Krensky AM, Simmen FA, Simmen RC. The Reproductive Phenotype of Mice Null for Transcription Factor Krüppel-Like Factor 13 (KLF13) Reveals Functions Distinct from Its Family Member KLF9 in Normal Female Fertility. Biology of Reproduction. 85: 464-464. DOI: 10.1093/Biolreprod/85.S1.464 |
0.767 |
|
| 2010 |
Dave B, Wynne R, Su Y, Korourian S, Chang JC, Simmen RC. Enhanced mammary progesterone receptor-A isoform activity in the promotion of mammary tumor progression by dietary soy in rats. Nutrition and Cancer. 62: 774-82. PMID 20661826 DOI: 10.1080/01635581.2010.494334 |
0.375 |
|
| 2010 |
Rahal OM, Simmen RC. PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation. Carcinogenesis. 31: 1491-500. PMID 20554748 DOI: 10.1093/Carcin/Bgq123 |
0.769 |
|
| 2010 |
Pabona JM, Zeng Z, Simmen FA, Simmen RC. Functional differentiation of uterine stromal cells involves cross-regulation between bone morphogenetic protein 2 and Kruppel-like factor (KLF) family members KLF9 and KLF13. Endocrinology. 151: 3396-406. PMID 20410205 DOI: 10.1210/En.2009-1370 |
0.368 |
|
| 2010 |
Simmons CD, Pabona JM, Zeng Z, Velarde MC, Gaddy D, Simmen FA, Simmen RC. Response of adult mouse uterus to early disruption of estrogen receptor-alpha signaling is influenced by Krüppel-like factor 9. The Journal of Endocrinology. 205: 147-57. PMID 20164373 DOI: 10.1677/Joe-09-0474 |
0.824 |
|
| 2010 |
Simmen RC, Pabona JM, Velarde MC, Simmons C, Rahal O, Simmen FA. The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues. The Journal of Endocrinology. 204: 223-31. PMID 19833720 DOI: 10.1677/Joe-09-0329 |
0.794 |
|
| 2009 |
Wu X, Rahal O, Kang J, Till SR, Prior RL, Simmen RC. In utero and lactational exposure to blueberry via maternal diet promotes mammary epithelial differentiation in prepubescent female rats. Nutrition Research (New York, N.Y.). 29: 802-11. PMID 19932869 DOI: 10.1016/J.Nutres.2009.10.015 |
0.753 |
|
| 2009 |
Su Y, Shankar K, Simmen RC. Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes. The Journal of Nutrition. 139: 945-51. PMID 19321580 DOI: 10.3945/jn.108.103820 |
0.367 |
|
| 2009 |
Su Y, Simmen RC. Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells. Carcinogenesis. 30: 331-9. PMID 19073877 DOI: 10.1093/carcin/bgn279 |
0.325 |
|
| 2009 |
Pabona JM, Velarde MC, Zeng Z, Simmen FA, Simmen RC. Nuclear receptor co-regulator Krüppel-like factor 9 and prohibitin 2 expression in estrogen-induced epithelial cell proliferation in the mouse uterus. The Journal of Endocrinology. 200: 63-73. PMID 18835980 DOI: 10.1677/Joe-08-0383 |
0.747 |
|
| 2009 |
Su Y, Shankar K, Simmen F, Simmen R. Regulation of adipocyte lipid homeostasis by genistein alters mammary epithelial cell differentiation: a paracrine mechanism for mammary tumor protection. Cancer Research. 69: 5082. DOI: 10.1158/0008-5472.Sabcs-5082 |
0.494 |
|
| 2009 |
Rahal O, Simmen R. Tumor suppressor PTEN signaling is up-regulated in mammary epithelial cells by soy isoflavone genistein: implications for breast cancer protection. Cancer Research. 69: 4069. DOI: 10.1158/0008-5472.Sabcs-4069 |
0.793 |
|
| 2009 |
Rahal O, Simmen R. Induction of PTEN-p53 Crosstalk in Mammary Epithelial Cells: A Novel Mechanism of Breast Cancer Prevention by the Dietary Factor Genistein. Cancer Research. 69: 3149-3149. DOI: 10.1158/0008-5472.Sabcs-09-3149 |
0.785 |
|
| 2008 |
Simmen FA, Su Y, Xiao R, Zeng Z, Simmen RC. The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression. Reproductive Biology and Endocrinology : Rb&E. 6: 41. PMID 18783612 DOI: 10.1186/1477-7827-6-41 |
0.355 |
|
| 2008 |
Zeng Z, Velarde MC, Simmen FA, Simmen RC. Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Krüppel-like factor 9. Biology of Reproduction. 78: 1029-37. PMID 18305227 DOI: 10.1095/Biolreprod.107.065821 |
0.721 |
|
| 2007 |
Velarde MC, Zeng Z, McQuown JR, Simmen FA, Simmen RC. Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells. Molecular Endocrinology (Baltimore, Md.). 21: 2988-3001. PMID 17717078 DOI: 10.1210/Me.2007-0242 |
0.72 |
|
| 2007 |
Simmen FA, Xiao R, Velarde MC, Nicholson RD, Bowman MT, Fujii-Kuriyama Y, Oh SP, Simmen RC. Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9. American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G1757-69. PMID 17379758 DOI: 10.1152/Ajpgi.00013.2007 |
0.675 |
|
| 2007 |
Su Y, Simmen FA, Xiao R, Simmen RC. Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors. Physiological Genomics. 30: 8-16. PMID 17341692 DOI: 10.1152/Physiolgenomics.00023.2007 |
0.366 |
|
| 2007 |
Wu X, Till SR, Badger TM, Prior RL, Simmen RC. Early Effects of Blueberry and Concord Grape Intake on Rat Mammary Gland Development Suggest Potential Protective Mechanisms for Mammary Tumorigenesis The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A366-D |
0.326 |
|
| 2007 |
Simmen R, Velarde M, Zeng Z, Simmen F, de Evsikova. C. ALTERED GESTATION LENGTH IN MICE NULL FOR THE KRUPPEL-LIKE FACTOR 9 GENE OR HETEROZYGOUS FOR THE LEPTIN RECEPTOR MUTATION: USEFUL MODELS FOR PARTURITION DEFECTS? Biology of Reproduction. 77: 231-232. DOI: 10.1093/Biolreprod/77.S1.231C |
0.678 |
|
| 2007 |
Velarde M, Simmen F, Simmen R. KRUPPEL-LIKE FACTOR 9 REGULATES CELL PROLIFERATION AND COMPARTMENTAL EXPRESSION OF ESTROGEN AND PROGESTERONE RECEPTORS IN THE MOUSE UTERINE ENDOMETRIUM Biology of Reproduction. 77: 182-183. DOI: 10.1093/Biolreprod/77.S1.182B |
0.751 |
|
| 2006 |
Kwak I, Song S, Blum JL, Simmen RC, Simmen FA. Enhancer- and silencer-like sequences that mediate insulin-like growth factor-binding protein-2 gene expression in uterine cells of pregnancy. Dna and Cell Biology. 25: 6-18. PMID 16405396 DOI: 10.1089/Dna.2006.25.6 |
0.31 |
|
| 2006 |
Velarde MC, Iruthayanathan M, Eason RR, Zhang D, Simmen FA, Simmen RC. Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1. Endocrinology. 147: 1969-78. PMID 16384861 DOI: 10.1210/En.2005-1419 |
0.713 |
|
| 2005 |
Eason RR, Till SR, Velarde MC, Geng Y, Chatman L, Gu L, Badger TM, Simmen FA, Simmen RC. Uterine phenotype of young adult rats exposed to dietary soy or genistein during development. The Journal of Nutritional Biochemistry. 16: 625-32. PMID 16081271 DOI: 10.1016/J.Jnutbio.2005.03.005 |
0.684 |
|
| 2005 |
Velarde MC, Geng Y, Eason RR, Simmen FA, Simmen RC. Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice. Biology of Reproduction. 73: 472-81. PMID 15917344 DOI: 10.1095/Biolreprod.105.041855 |
0.711 |
|
| 2005 |
Simmen RC, Eason RR, Till SR, Chatman L, Velarde MC, Geng Y, Korourian S, Badger TM. Inhibition of NMU-induced mammary tumorigenesis by dietary soy. Cancer Letters. 224: 45-52. PMID 15911100 DOI: 10.1016/J.Canlet.2004.11.009 |
0.67 |
|
| 2005 |
Dave B, Eason RR, Till SR, Geng Y, Velarde MC, Badger TM, Simmen RC. The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis. 26: 1793-803. PMID 15905199 DOI: 10.1093/Carcin/Bgi131 |
0.701 |
|
| 2005 |
Velarde MC, Parisek SI, Eason RR, Simmen FA, Simmen RC. The secretory leukocyte protease inhibitor gene is a target of epidermal growth factor receptor action in endometrial epithelial cells. The Journal of Endocrinology. 184: 141-51. PMID 15642791 DOI: 10.1677/Joe.1.05800 |
0.713 |
|
| 2004 |
Eason RR, Velarde MC, Chatman L, Till SR, Geng Y, Ferguson M, Badger TM, Simmen RC. Dietary exposure to whey proteins alters rat mammary gland proliferation, apoptosis, and gene expression during postnatal development. The Journal of Nutrition. 134: 3370-7. PMID 15570039 DOI: 10.1093/Jn/134.12.3370 |
0.68 |
|
| 2004 |
Simmen RC, Eason RR, McQuown JR, Linz AL, Kang TJ, Chatman L, Till SR, Fujii-Kuriyama Y, Simmen FA, Oh SP. Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene. The Journal of Biological Chemistry. 279: 29286-94. PMID 15117941 DOI: 10.1074/Jbc.M403139200 |
0.394 |
|
| 2004 |
Kowalski AA, Vale-Cruz DS, Simmen FA, Simmen RC. Uterine androgen receptors: roles in estrogen-mediated gene expressionand DNA synthesis. Biology of Reproduction. 70: 1349-57. PMID 14711790 DOI: 10.1095/Biolreprod.103.024786 |
0.784 |
|
| 2003 |
Zhang XL, Zhang D, Michel FJ, Blum JL, Simmen FA, Simmen RC. Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells. The Journal of Biological Chemistry. 278: 21474-82. PMID 12672823 DOI: 10.1074/Jbc.M212098200 |
0.326 |
|
| 2002 |
Simmen RC, Simmen FA. Progesterone receptors and Sp/Krüppel-like family members in the uterine endometrium . Frontiers in Bioscience : a Journal and Virtual Library. 7: d1556-65. PMID 12045021 DOI: 10.2741/Simmen |
0.308 |
|
| 2002 |
Zhang D, Simmen RC, Michel FJ, Zhao G, Vale-Cruz D, Simmen FA. Secretory leukocyte protease inhibitor mediates proliferation of human endometrial epithelial cells by positive and negative regulation of growth-associated genes. The Journal of Biological Chemistry. 277: 29999-30009. PMID 12023969 DOI: 10.1074/Jbc.M203503200 |
0.33 |
|
| 2002 |
Simmen RC, Zhang XL, Michel FJ, Min SH, Zhao G, Simmen FA. Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Krüppel-like factor BTEB1. Dna and Cell Biology. 21: 115-28. PMID 11953011 DOI: 10.1089/104454902753604998 |
0.33 |
|
| 2002 |
Kowalski AA, Graddy LG, Vale-Cruz DS, Choi I, Katzenellenbogen BS, Simmen FA, Simmen RC. Molecular cloning of porcine estrogen receptor-beta complementary DNAs and developmental expression in periimplantation embryos. Biology of Reproduction. 66: 760-9. PMID 11870084 DOI: 10.1095/Biolreprod66.3.760 |
0.78 |
|
| 2000 |
Modric T, Kowalski AA, Green ML, Simmen RC, Simmen FA. Pregnancy-dependent expression of leukaemia inhibitory factor (LIF), LIF receptor-beta and interleukin-6 (IL-6) messenger ribonucleic acids in the porcine female reproductive tract. Placenta. 21: 345-53. PMID 10833369 DOI: 10.1053/Plac.1999.0493 |
0.76 |
|
| 1991 |
Fliss AE, Michel FJ, Chen CL, Hofig A, Bazer FW, Chou JY, Simmen RC. Regulation of the uteroferrin gene promoter in endometrial cells: interactions among estrogen, progesterone, and prolactin. Endocrinology. 129: 697-704. PMID 1855467 DOI: 10.1210/Endo-129-2-697 |
0.309 |
|
| 1989 |
Simmen RC, Simmen FA, Ko Y, Bazer FW. Differential growth factor content of uterine luminal fluids from large white and prolific Meishan pigs during the estrous cycle and early pregnancy Journal of Animal Science. 67: 1538-1545. PMID 2768111 DOI: 10.2527/Jas1989.6761538X |
0.305 |
|
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