| Year |
Citation |
Score |
| 2022 |
Wu H, Bierbach U. Chemosensitivity-Gene Expression Correlations and Functional Enrichment Analysis Provide Insight into the Mechanism of Action of a Platinum-Acridine Anticancer Agent. Chemmedchem. PMID 35902361 DOI: 10.1002/cmdc.202200331 |
0.327 |
|
| 2022 |
Green AT, Pickard AJ, Li R, MacKerell AD, Bierbach U, Cho SS. Computational and Experimental Characterization of rDNA and rRNA G-Quadruplexes. The Journal of Physical Chemistry. B. PMID 35026949 DOI: 10.1021/acs.jpcb.1c08340 |
0.694 |
|
| 2021 |
Yao X, Bierbach U. DNA Adduct Detection after Post-Labeling Technique with PCR Amplification (DNA-ADAPT-qPCR) Identifies the Pre-Ribosomal RNA Gene as a Direct Target of Platinum-Acridine Anticancer Agents. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34375484 DOI: 10.1002/chem.202102263 |
0.415 |
|
| 2020 |
Bierbach U, Zhang S, Yao X, Watkins N, Rose P, Caruso S, Day C. Discovery of a Chiral DNA-Targeted Platinum-Acridine Agent with Potent Enantioselective Anticancer Activity. Angewandte Chemie (International Ed. in English). PMID 32835419 DOI: 10.1002/anie.202009983 |
0.35 |
|
| 2019 |
Rose PK, Watkins NH, Yao X, Zhang S, Mancera-Ortiz IY, Sloop JT, Donati GL, Day CS, Bierbach U. Effect of the nonleaving groups on the cellular uptake and cytotoxicity of platinum-acridine anticancer agents Inorganica Chimica Acta. 492: 150-155. DOI: 10.1016/J.Ica.2019.04.030 |
0.316 |
|
| 2018 |
Yang M, Wu H, Chu J, Gabriel LA, Kim Y, Anderson KS, Furdui CM, Bierbach U. Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent. Chemical Communications (Cambridge, England). PMID 29915817 DOI: 10.1039/C8Cc04251A |
0.485 |
|
| 2017 |
Dean TC, Yang M, Liu M, Grayson JM, DeMartino AW, Day CS, Lee J, Furdui CM, Bierbach U. Human Serum Albumin-Delivered [Au(PEt3)](+) Is a Potent Inhibitor of T Cell Proliferation. Acs Medicinal Chemistry Letters. 8: 572-576. PMID 28523113 DOI: 10.1021/Acsmedchemlett.7B00142 |
0.514 |
|
| 2016 |
Fahrenholtz CD, Ding S, Bernish BW, Wright ML, Zheng Y, Yang M, Yao X, Donati GL, Gross MD, Bierbach U, Singh R. Design and cellular studies of a carbon nanotube-based delivery system for a hybrid platinum-acridine anticancer agent. Journal of Inorganic Biochemistry. PMID 27496614 DOI: 10.1016/J.Jinorgbio.2016.07.016 |
0.487 |
|
| 2016 |
Ding S, Bierbach U. Linker design for the modular assembly of multifunctional and targeted platinum(ii)-containing anticancer agents. Dalton Transactions (Cambridge, England : 2003). PMID 27251881 DOI: 10.1039/c6dt01399f |
0.315 |
|
| 2016 |
Yang M, Bierbach U. Metal-Containing Pharmacophores in Molecularly Targeted Anticancer Therapies and Diagnostics European Journal of Inorganic Chemistry. 2017: 1561-1572. DOI: 10.1002/EJIC.201601149 |
0.44 |
|
| 2015 |
Liu F, Suryadi J, Bierbach U. Cellular Recognition and Repair of Monofunctional-Intercalative Platinum-DNA Adducts. Chemical Research in Toxicology. PMID 26457537 DOI: 10.1021/acs.chemrestox.5b00327 |
0.409 |
|
| 2015 |
Langston PK, Yang M, Bierbach U, Parsonage D, Poole LB, Price MJ, Grayson JM. Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function. Journal of Immunology (Baltimore, Md. : 1950). 195: 1984-94. PMID 26209624 DOI: 10.4049/Jimmunol.1400391 |
0.456 |
|
| 2015 |
Yang M, Pickard AJ, Qiao X, Gueble MJ, Day CS, Kucera GL, Bierbach U. Synthesis, reactivity, and biological activity of gold(I) complexes modified with thiourea-functionalized tyrosine kinase inhibitors. Inorganic Chemistry. 54: 3316-24. PMID 25793564 DOI: 10.1021/Ic502998A |
0.748 |
|
| 2014 |
Ding S, Pickard AJ, Kucera GL, Bierbach U. Design of enzymatically cleavable prodrugs of a potent platinum-containing anticancer agent. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 16164-73. PMID 25303639 DOI: 10.1002/Chem.201404675 |
0.716 |
|
| 2014 |
Pickard AJ, Liu F, Bartenstein TF, Haines LG, Levine KE, Kucera GL, Bierbach U. Redesigning the DNA-targeted chromophore in platinum-acridine anticancer agents: a structure-activity relationship study. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 16174-87. PMID 25302716 DOI: 10.1002/Chem.201404845 |
0.758 |
|
| 2014 |
Qiao X, Ding S, Liu F, Kucera GL, Bierbach U. Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 19: 415-26. PMID 24407462 DOI: 10.1007/S00775-013-1086-1 |
0.377 |
|
| 2013 |
Pickard AJ, Bierbach U. The cell's nucleolus: an emerging target for chemotherapeutic intervention. Chemmedchem. 8: 1441-9. PMID 23881648 DOI: 10.1002/Cmdc.201300262 |
0.695 |
|
| 2013 |
Dutta S, Snyder MJ, Rosile D, Binz KL, Roll EH, Suryadi J, Bierbach U, Guthold M. PT-ACRAMTU, a platinum-acridine anticancer agent, lengthens and aggregates, but does not stiffen or soften DNA. Cell Biochemistry and Biophysics. 67: 1103-13. PMID 23636685 DOI: 10.1007/S12013-013-9614-8 |
0.42 |
|
| 2013 |
Ding S, Qiao X, Suryadi J, Marrs GS, Kucera GL, Bierbach U. Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents. Angewandte Chemie (International Ed. in English). 52: 3350-4. PMID 23427109 DOI: 10.1002/Anie.201210079 |
0.332 |
|
| 2012 |
Ding S, Qiao X, Kucera GL, Bierbach U. Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents. Journal of Medicinal Chemistry. 55: 10198-203. PMID 23074987 DOI: 10.1021/Jm301278C |
0.368 |
|
| 2012 |
Suryadi J, Bierbach U. DNA metalating-intercalating hybrid agents for the treatment of chemoresistant cancers. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 12926-34. PMID 22987397 DOI: 10.1002/chem.201202050 |
0.379 |
|
| 2012 |
Cheung-Ong K, Song KT, Ma Z, Shabtai D, Lee AY, Gallo D, Heisler LE, Brown GW, Bierbach U, Giaever G, Nislow C. Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents. Acs Chemical Biology. 7: 1892-901. PMID 22928710 DOI: 10.1021/Cb300320D |
0.64 |
|
| 2012 |
Graham LA, Suryadi J, West TK, Kucera GL, Bierbach U. Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents. Journal of Medicinal Chemistry. 55: 7817-27. PMID 22871158 DOI: 10.1021/Jm300879K |
0.604 |
|
| 2012 |
Qiao X, Zeitany AE, Wright MW, Essader AS, Levine KE, Kucera GL, Bierbach U. Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells. Metallomics : Integrated Biometal Science. 4: 645-52. PMID 22456976 DOI: 10.1039/C2Mt20031G |
0.422 |
|
| 2011 |
Smyre CL, Saluta G, Kute TE, Kucera GL, Bierbach U. Inhibition of DNA Synthesis by a Platinum-Acridine Hybrid Agent Leads to Potent Cell Kill in Non-Small Cell Lung Cancer. Acs Medicinal Chemistry Letters. 2: 870-874. PMID 22328962 DOI: 10.1021/Ml2001888 |
0.365 |
|
| 2011 |
Rao L, Dworkin JD, Nell WE, Bierbach U. Interactions of a platinum-modified perylene derivative with the human telomeric G-quadruplex. The Journal of Physical Chemistry. B. 115: 13701-12. PMID 21999566 DOI: 10.1021/Jp207265S |
0.636 |
|
| 2011 |
Graham LA, Wilson GM, West TK, Day CS, Kucera GL, Bierbach U. Unusual Reactivity of a Potent Platinum-Acridine Hybrid Antitumor Agent. Acs Medicinal Chemistry Letters. 2: 687-691. PMID 21927647 DOI: 10.1021/Ml200104H |
0.636 |
|
| 2011 |
Kostrhunova H, Malina J, Pickard AJ, Stepankova J, Vojtiskova M, Kasparkova J, Muchova T, Rohlfing ML, Bierbach U, Brabec V. Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair. Molecular Pharmaceutics. 8: 1941-54. PMID 21806015 DOI: 10.1021/Mp200309X |
0.76 |
|
| 2011 |
Choudhury JR, Rao L, Bierbach U. Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 16: 373-80. PMID 21086002 DOI: 10.1007/S00775-010-0733-Z |
0.759 |
|
| 2010 |
Rao L, West TK, Saluta G, Kucera GL, Bierbach U. Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agents. Chemical Research in Toxicology. 23: 1148-50. PMID 20578739 DOI: 10.1021/Tx100170P |
0.694 |
|
| 2009 |
Eiter LC, Hall NW, Day CS, Saluta G, Kucera GL, Bierbach U. Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis. Journal of Medicinal Chemistry. 52: 6519-22. PMID 19803526 DOI: 10.1021/Jm9012856 |
0.364 |
|
| 2009 |
Kheradi AR, Saluta G, Kucera GL, Day CS, Bierbach U. Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups. Bioorganic & Medicinal Chemistry Letters. 19: 3423-5. PMID 19477643 DOI: 10.1016/J.Bmcl.2009.05.046 |
0.31 |
|
| 2009 |
Ma Z, Rao L, Bierbach U. Replacement of a thiourea-S with an amidine-NH donor group in a platinum-acridine antitumor compound reduces the metal's reactivity with cysteine sulfur. Journal of Medicinal Chemistry. 52: 3424-7. PMID 19397321 DOI: 10.1021/Jm900451Y |
0.72 |
|
| 2008 |
Ma Z, Choudhury JR, Wright MW, Day CS, Saluta G, Kucera GL, Bierbach U. A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer. Journal of Medicinal Chemistry. 51: 7574-80. PMID 19012390 DOI: 10.1021/Jm800900G |
0.792 |
|
| 2008 |
Ma Z, Saluta G, Kucera GL, Bierbach U. Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines. Bioorganic & Medicinal Chemistry Letters. 18: 3799-801. PMID 18515101 DOI: 10.1016/J.Bmcl.2008.05.043 |
0.62 |
|
| 2008 |
Choudhury JR, Guddneppanavar R, Saluta G, Kucera GL, Bierbach U. Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups. Journal of Medicinal Chemistry. 51: 3069-72. PMID 18457380 DOI: 10.1021/Jm8003569 |
0.768 |
|
| 2007 |
Rao L, Bierbach U. Kinetically favored platination of adenine in the g-rich human telomeric repeat. Journal of the American Chemical Society. 129: 15764-5. PMID 18047349 DOI: 10.1021/Ja077390A |
0.668 |
|
| 2007 |
Ma Z, Day CS, Bierbach U. Unexpected reactivity of the 9-aminoacridine chromophore in guanidylation reactions. The Journal of Organic Chemistry. 72: 5387-90. PMID 17552568 DOI: 10.1021/Jo0705972 |
0.599 |
|
| 2007 |
Guddneppanavar R, Choudhury JR, Kheradi AR, Steen BD, Saluta G, Kucera GL, Day CS, Bierbach U. Effect of the diamine nonleaving group in platinum-acridinylthiourea conjugates on DNA damage and cytotoxicity. Journal of Medicinal Chemistry. 50: 2259-63. PMID 17408248 DOI: 10.1021/Jm0614376 |
0.736 |
|
| 2007 |
Guddneppanavar R, Bierbach U. Adenine-N3 in the DNA minor groove - an emerging target for platinum containing anticancer pharmacophores. Anti-Cancer Agents in Medicinal Chemistry. 7: 125-38. PMID 17266509 DOI: 10.2174/187152007779313991 |
0.422 |
|
| 2006 |
Guddneppanavar R, Saluta G, Kucera GL, Bierbach U. Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine. Journal of Medicinal Chemistry. 49: 3204-14. PMID 16722638 DOI: 10.1021/Jm060035V |
0.468 |
|
| 2006 |
Farrell N, Qu Y, Bierbach U, Valsecchi M, Mentab E. Structure-Activity Relationships Within Di- and Trinuclear Platinum Phase-I Clinical Anticancer Agents Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug. 477-496. DOI: 10.1002/9783906390420.ch19 |
0.378 |
|
| 2005 |
Choudhury JR, Bierbach U. Characterization of the bisintercalative DNA binding mode of a bifunctional platinum-acridine agent. Nucleic Acids Research. 33: 5622-32. PMID 16192574 DOI: 10.1093/Nar/Gki869 |
0.786 |
|
| 2005 |
Budiman ME, Bierbach U, Alexander RW. DNA minor groove adducts formed by a platinum-acridine conjugate inhibit association of tata-binding protein with its cognate sequence. Biochemistry. 44: 11262-8. PMID 16101310 DOI: 10.1021/bi050745n |
0.386 |
|
| 2005 |
Ma Y, Day CS, Bierbach U. Synthesis, structure, and reactivity of monofunctional platinum(II) and palladium(II) complexes containing the sterically hindered ligand 6-(methylpyridin-2-yl)acetate. Journal of Inorganic Biochemistry. 99: 2013-23. PMID 16087242 DOI: 10.1016/j.jinorgbio.2005.06.021 |
0.348 |
|
| 2005 |
Hess SM, Mounce AM, Sequeira RC, Augustus TM, Ackley MC, Bierbach U. Platinum-acridinylthiourea conjugates show cell line-specific cytotoxic enhancement in H460 lung carcinoma cells compared to cisplatin. Cancer Chemotherapy and Pharmacology. 56: 337-43. PMID 15895232 DOI: 10.1007/s00280-004-0987-7 |
0.344 |
|
| 2005 |
Baruah H, Wright MW, Bierbach U. Solution structural study of a DNA duplex containing the guanine-N7 adduct formed by a cytotoxic platinum-acridine hybrid agent. Biochemistry. 44: 6059-70. PMID 15835895 DOI: 10.1021/Bi050021B |
0.729 |
|
| 2005 |
Barry CG, Day CS, Bierbach U. Duplex-promoted platination of adenine-N3 in the minor groove of DNA: challenging a longstanding bioinorganic paradigm. Journal of the American Chemical Society. 127: 1160-9. PMID 15669855 DOI: 10.1021/ja0451620 |
0.358 |
|
| 2004 |
Baruah H, Barry CG, Bierbach U. Platinum-intercalator conjugates: from DNA-targeted cisplatin derivatives to adenine binding complexes as potential modulators of gene regulation. Current Topics in Medicinal Chemistry. 4: 1537-49. PMID 15579095 DOI: 10.2174/1568026043387313 |
0.741 |
|
| 2004 |
Budiman ME, Alexander RW, Bierbach U. Unique base-step recognition by a platinum-acridinylthiourea conjugate leads to a DNA damage profile complementary to that of the anticancer drug cisplatin. Biochemistry. 43: 8560-7. PMID 15222767 DOI: 10.1021/bi049415d |
0.373 |
|
| 2004 |
Baruah H, Day CS, Wright MW, Bierbach U. Metal-intercalator-mediated self-association and one-dimensional aggregation in the structure of the excised major DNA adduct of a platinum-acridine agent. Journal of the American Chemical Society. 126: 4492-3. PMID 15070347 DOI: 10.1021/Ja038592J |
0.734 |
|
| 2004 |
Ackley MC, Barry CG, Mounce AM, Farmer MC, Springer BE, Day CS, Wright MW, Berners-Price SJ, Hess SM, Bierbach U. Structure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 453-61. PMID 15067524 DOI: 10.1007/s00775-004-0541-4 |
0.367 |
|
| 2004 |
Baruah H, Bierbach U. Biophysical characterization and molecular modeling of the coordinative-intercalative DNA monoadduct of a platinum-acridinylthiourea agent in a site-specifically modified dodecamer. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 335-44. PMID 15024635 DOI: 10.1007/S00775-004-0534-3 |
0.698 |
|
| 2003 |
Barry CG, Baruah H, Bierbach U. Unprecedented monofunctional metalation of adenine nucleobase in guanine- and thymine-containing dinucleotide sequences by a cytotoxic platinum-acridine hybrid agent. Journal of the American Chemical Society. 125: 9629-37. PMID 12904029 DOI: 10.1021/Ja0351443 |
0.728 |
|
| 2003 |
Baruah H, Bierbach U. Unusual intercalation of acridin-9-ylthiourea into the 5'-GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugate. Nucleic Acids Research. 31: 4138-46. PMID 12853631 DOI: 10.1093/Nar/Gkg465 |
0.693 |
|
| 2003 |
Augustus TM, Anderson J, Hess SM, Bierbach U. Bis(acridinylthiourea)platinum(II) complexes: synthesis, DNA affinity, and biological activity in glioblastoma cells. Bioorganic & Medicinal Chemistry Letters. 13: 855-8. PMID 12617907 DOI: 10.1016/S0960-894X(02)01078-8 |
0.373 |
|
| 2002 |
Barry CG, Turney EC, Day CS, Saluta G, Kucera GL, Bierbach U. Thermally inert metal ammines as light-inducible DNA-targeted agents. Synthesis, photochemistry, and photobiology of a prototypical rhodium(III)-intercalator conjugate. Inorganic Chemistry. 41: 7159-69. PMID 12495358 DOI: 10.1021/Ic025744N |
0.441 |
|
| 2002 |
Brow JM, Pleatman CR, Bierbach U. Cytotoxic acridinylthiourea and its platinum conjugate produce enzyme-mediated DNA strand breaks. Bioorganic & Medicinal Chemistry Letters. 12: 2953-5. PMID 12270182 DOI: 10.1016/S0960-894X(02)00620-0 |
0.368 |
|
| 2002 |
Baruah H, Rector CL, Monnier SM, Bierbach U. Mechanism of action of non-cisplatin type DNA-targeted platinum anticancer agents: DNA interactions of novel acridinylthioureas and their platinum conjugates. Biochemical Pharmacology. 64: 191-200. PMID 12123739 DOI: 10.1016/S0006-2952(02)01107-3 |
0.737 |
|
| 2001 |
Martins ET, Baruah H, Kramarczyk J, Saluta G, Day CS, Kucera GL, Bierbach U. Design, synthesis, and biological activity of a novel non-cisplatin-type platinum-acridine pharmacophore. Journal of Medicinal Chemistry. 44: 4492-6. PMID 11728195 DOI: 10.1021/Jm010293M |
0.674 |
|
| 2000 |
Bierbach U, Sabat M, Farrell N. Inversion of the cis geometry requirement for cytotoxicity in structurally novel platinum(II) complexes containing the bidentate N,O-donor pyridin-2-yl-acetate. Inorganic Chemistry. 39: 1882-90. PMID 11428108 DOI: 10.1021/Ic991259P |
0.305 |
|
| 1998 |
Žákovská A, Nováková O, Balcarová Z, Bierbach U, Farrell N, Brabec V. DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)] European Journal of Biochemistry. 254: 547-557. PMID 9688265 DOI: 10.1046/J.1432-1327.1998.2540547.X |
0.446 |
|
| 1997 |
Bierbach U, Farrell N. Modulation of Nucleotide Binding of trans Platinum(II) Complexes by Planar Ligands. A Combined Proton NMR and Molecular Mechanics Study. Inorganic Chemistry. 36: 3657-3665. PMID 11670057 DOI: 10.1021/Ic970154O |
0.314 |
|
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