| Year |
Citation |
Score |
| 2024 |
Goupil E, Lacroix L, Brière J, Guga S, Saba-El-Leil MK, Meloche S, Labbé JC. OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis. Proceedings of the National Academy of Sciences of the United States of America. 121: e2308570121. PMID 38442170 DOI: 10.1073/pnas.2308570121 |
0.317 |
|
| 2023 |
Serwe G, Kachaner D, Gagnon J, Plutoni C, Lajoie D, Duramé E, Sahmi M, Garrido D, Lefrançois M, Arseneault G, Saba-El-Leil MK, Meloche S, Emery G, Therrien M. CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling. Nature Communications. 14: 3560. PMID 37322019 DOI: 10.1038/s41467-023-39281-z |
0.419 |
|
| 2023 |
Pelletier B, Duhamel S, Tambutet G, Jarvis S, Cléroux P, David M, Tanguay PL, Voisin L, James C, Lavoie R, Gareau Y, Flynn-Robitaille J, Lorca T, Ruel R, Marinier A, ... Meloche S, et al. Discovery of Benzodiazepine-Based Inhibitors of the E2 Enzyme UBCH10 from a Cell-Based p21 Degradation Screen. Acs Chemical Biology. PMID 37097827 DOI: 10.1021/acschembio.2c00909 |
0.778 |
|
| 2022 |
Boudghene-Stambouli F, Soulez M, Ronkina N, Dörrie A, Kotlyarov A, Seternes OM, Gaestel M, Meloche S. On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer. Cancers. 15. PMID 36612022 DOI: 10.3390/cancers15010025 |
0.469 |
|
| 2022 |
Javary J, Goupil E, Soulez M, Kanshin E, Bouchard A, Seternes OM, Thibault P, Labbé JC, Meloche S. Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy. Journal of Cellular Physiology. PMID 36576983 DOI: 10.1002/jcp.30938 |
0.526 |
|
| 2022 |
Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean É, Guérin CM, Bouttier M, Grondin B, Lin S, Saba-El-Leil MK, Angers S, Meloche S, Roux PP. CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma. Nature Communications. 13: 6457. PMID 36309522 DOI: 10.1038/s41467-022-34179-8 |
0.41 |
|
| 2022 |
Soulez M, Tanguay PL, Dô F, Dort J, Crist C, Kotlyarov A, Gaestel M, Ferron M, Dumont NA, Meloche S. ERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation. Journal of Cellular Physiology. PMID 35141958 DOI: 10.1002/jcp.30695 |
0.834 |
|
| 2022 |
Guégan JP, Lapouge M, Voisin L, Saba-El-Leil MK, Tanguay PL, Lévesque K, Brégeon J, Mes-Masson AM, Lamarre D, Haibe-Kains B, Trinh VQ, Soucy G, Bilodeau M, Meloche S. Signaling by the tyrosine kinase Yes promotes liver cancer development. Science Signaling. 15: eabj4743. PMID 35041461 DOI: 10.1126/scisignal.abj4743 |
0.802 |
|
| 2021 |
Mathien S, Tesnière C, Meloche S. Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential. Pharmacological Reviews. 73: 263-296. PMID 34732541 DOI: 10.1124/pharmrev.120.000170 |
0.5 |
|
| 2020 |
Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, ... Meloche S, et al. Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer. Nature Communications. 11: 3701. PMID 32709883 DOI: 10.1038/S41467-020-17549-Y |
0.311 |
|
| 2019 |
Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P, Klinger S, Rousseau J, Lévesque K, Meloche S. Reevaluation of the Role of ERK3 in Perinatal Survival and Post-Natal Growth Using New Genetically-Engineered Mouse Models. Molecular and Cellular Biology. PMID 30642949 DOI: 10.1128/Mcb.00527-18 |
0.302 |
|
| 2017 |
Pyakurel A, Balmer D, Saba-El-Leil MK, Kizilyaprak C, Daraspe J, Humbel BM, Voisin L, Le YZ, von Lintig J, Meloche S, Roduit R. Loss of ERK1/2 in the retinal pigment epithelium leads to RPE65 decrease and retinal degeneration. Molecular and Cellular Biology. PMID 29038159 DOI: 10.1128/MCB.00295-17 |
0.363 |
|
| 2017 |
Sipthorp J, Lebraud H, Gilley R, Kidger A, Okkenhaug H, Saba-El-Leil MK, Meloche S, Caunt CJ, Cook S, Heightman TD. Visualisation of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe. Bioconjugate Chemistry. PMID 28449575 DOI: 10.1021/acs.bioconjchem.7b00152 |
0.33 |
|
| 2017 |
Mathien S, Déléris P, Soulez M, Voisin L, Meloche S. The Deubiquitinating Enzyme USP20 Regulates ERK3 Stability and Biological Activity. Molecular and Cellular Biology. PMID 28167606 DOI: 10.1128/Mcb.00432-16 |
0.508 |
|
| 2017 |
Saba-El-Leil MK, Frémin C, Meloche S. Isolation of Mouse Embryonic Stem Cell Lines in the Study of ERK1/2 MAP Kinase Signaling. Methods in Molecular Biology (Clifton, N.J.). 1487: 243-253. PMID 27924572 DOI: 10.1007/978-1-4939-6424-6_18 |
0.324 |
|
| 2016 |
Saba-El-Leil MK, Frémin C, Meloche S. Redundancy in the World of MAP Kinases: All for One. Frontiers in Cell and Developmental Biology. 4: 67. PMID 27446918 DOI: 10.3389/fcell.2016.00067 |
0.504 |
|
| 2016 |
Duhamel S, Girondel C, Dorn JF, Tanguay PL, Voisin L, Smits R, Maddox PS, Meloche S. Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway. Cell Cycle (Georgetown, Tex.). 0. PMID 27152455 DOI: 10.1080/15384101.2016.1183851 |
0.827 |
|
| 2016 |
Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G. Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors. Blood. PMID 27034432 DOI: 10.1182/Blood-2016-03-705053 |
0.328 |
|
| 2015 |
Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G. The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias. Nature Genetics. 47: 1030-7. PMID 26237430 DOI: 10.1038/Ng.3371 |
0.345 |
|
| 2015 |
Frémin C, Saba-El-Leil MK, Lévesque K, Ang SL, Meloche S. Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development. Cell Reports. 12: 913-21. PMID 26235619 DOI: 10.1016/J.Celrep.2015.07.011 |
0.586 |
|
| 2015 |
Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau G. E4F1 is a master regulator of CHK1-mediated functions. Cell Reports. 11: 210-9. PMID 25843717 DOI: 10.1016/J.Celrep.2015.03.019 |
0.773 |
|
| 2015 |
Sirois J, Daudelin JF, Boulet S, Marquis M, Meloche S, Labrecque N. The atypical MAPK ERK3 controls positive selection of thymocytes. Immunology. 145: 161-9. PMID 25521218 DOI: 10.1111/Imm.12433 |
0.477 |
|
| 2014 |
Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Blood. 124: 2362-9. PMID 25185265 DOI: 10.1182/Blood-2014-01-548651 |
0.37 |
|
| 2014 |
Redwan IN, Dyrager C, Solano C, Fernández de Trocóniz G, Voisin L, Bliman D, Meloche S, Grøtli M. Towards the development of chromone-based MEK1/2 modulators. European Journal of Medicinal Chemistry. 85: 127-38. PMID 25078316 DOI: 10.1016/J.Ejmech.2014.07.018 |
0.386 |
|
| 2014 |
Marquis M, Daudelin JF, Boulet S, Sirois J, Crain K, Mathien S, Turgeon B, Rousseau J, Meloche S, Labrecque N. The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival. Molecular and Cellular Biology. 34: 3374-87. PMID 25002529 DOI: 10.1128/Mcb.01701-13 |
0.553 |
|
| 2014 |
Marquis M, Boulet S, Mathien S, Rousseau J, Thébault P, Daudelin JF, Rooney J, Turgeon B, Beauchamp C, Meloche S, Labrecque N. The non-classical MAP kinase ERK3 controls T cell activation. Plos One. 9: e86681. PMID 24475167 DOI: 10.1371/Journal.Pone.0086681 |
0.498 |
|
| 2014 |
Deschênes-Simard X, Kottakis F, Meloche S, Ferbeyre G. ERKs in cancer: friends or foes? Cancer Research. 74: 412-9. PMID 24408923 DOI: 10.1158/0008-5472.Can-13-2381 |
0.478 |
|
| 2013 |
Courcelles M, Frémin C, Voisin L, Lemieux S, Meloche S, Thibault P. Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Molecular Systems Biology. 9: 669. PMID 23712012 DOI: 10.1038/Msb.2013.25 |
0.591 |
|
| 2013 |
Wang J, Kong G, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J. Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood. 121: 5203-7. PMID 23687087 DOI: 10.1182/Blood-2012-12-475863 |
0.41 |
|
| 2013 |
Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G. Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes & Development. 27: 900-15. PMID 23599344 DOI: 10.1101/Gad.203984.112 |
0.556 |
|
| 2013 |
Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden KLB, Meloche S, Roux PP. RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth Oncogene. 32: 2917-2926. PMID 22797077 DOI: 10.1038/Onc.2012.312 |
0.565 |
|
| 2012 |
Trost M, Sauvageau M, Hérault O, Deleris P, Pomiès C, Chagraoui J, Mayotte N, Meloche S, Sauvageau G, Thibault P. Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood. 120: e17-27. PMID 22802335 DOI: 10.1182/Blood-2011-12-397844 |
0.408 |
|
| 2012 |
van Zuylen WJ, Doyon P, Clément JF, Khan KA, D'Ambrosio LM, Dô F, St-Amant-Verret M, Wissanji T, Emery G, Gingras AC, Meloche S, Servant MJ. Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity. Plos Pathogens. 8: e1002747. PMID 22792062 DOI: 10.1371/Journal.Ppat.1002747 |
0.355 |
|
| 2012 |
Meloche S, Roux PP. F-box proteins elongate translation during stress recovery. Science Signaling. 5: pe25. PMID 22669843 DOI: 10.1126/Scisignal.2003163 |
0.443 |
|
| 2012 |
Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A. The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology. Molecular and Cellular Biology. 32: 2467-78. PMID 22508986 DOI: 10.1128/Mcb.06633-11 |
0.561 |
|
| 2012 |
Duhamel S, Hébert J, Gaboury L, Bouchard A, Simon R, Sauter G, Basik M, Meloche S. Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation. Cancer Research. 72: 626-35. PMID 22298595 DOI: 10.1158/0008-5472.Can-11-2126 |
0.809 |
|
| 2011 |
Courcelles M, Lemieux S, Voisin L, Meloche S, Thibault P. ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses. Proteomics. 11: 2654-71. PMID 21630457 DOI: 10.1002/Pmic.201000776 |
0.398 |
|
| 2011 |
Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden KL, Thibault P, Meloche S. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. The Journal of Biological Chemistry. 286: 6470-8. PMID 21177870 DOI: 10.1074/Jbc.M110.181529 |
0.854 |
|
| 2011 |
Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD. Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circulation Research. 108: 176-83. PMID 21127295 DOI: 10.1161/Circresaha.110.231514 |
0.361 |
|
| 2011 |
Galisson F, Mahrouche L, Courcelles M, Bonneil E, Meloche S, Chelbi-Alix MK, Thibault P. A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells. Molecular & Cellular Proteomics : McP. 10: M110.004796. PMID 21098080 DOI: 10.1074/Mcp.M110.004796 |
0.348 |
|
| 2011 |
Servant MJ, Clément J, Meloche S. The IKK-related kinases, unsuspected culprits in oncogenesis? Atlas of Genetics and Cytogenetics in Oncology and Haematology. DOI: 10.4267/2042/44696 |
0.493 |
|
| 2010 |
Rousseau J, Klinger S, Rachalski A, Turgeon B, Déléris P, Vigneault E, Poirier-Héon JF, Davoli MA, Mechawar N, El Mestikawy S, Cermakian N, Meloche S. Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases. Molecular and Cellular Biology. 30: 5752-63. PMID 20956558 DOI: 10.1128/Mcb.01147-10 |
0.534 |
|
| 2010 |
Voisin L, Saba-El-Leil MK, Julien C, Frémin C, Meloche S. Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Molecular and Cellular Biology. 30: 2918-32. PMID 20368360 DOI: 10.1128/Mcb.00131-10 |
0.845 |
|
| 2010 |
Tanguay PL, Rodier G, Meloche S. C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis. The Biochemical Journal. 428: 103-11. PMID 20236090 DOI: 10.1042/Bj20091604 |
0.849 |
|
| 2010 |
Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche S. Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2. Cell Cycle (Georgetown, Tex.). 9: 975-9. PMID 20160482 DOI: 10.4161/Cc.9.5.10915 |
0.819 |
|
| 2010 |
Frémin C, Meloche S. From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. Journal of Hematology & Oncology. 3: 8. PMID 20149254 DOI: 10.1186/1756-8722-3-8 |
0.518 |
|
| 2009 |
Klinger S, Turgeon B, Lévesque K, Wood GA, Aagaard-Tillery KM, Meloche S. Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. Proceedings of the National Academy of Sciences of the United States of America. 106: 16710-5. PMID 19805361 DOI: 10.1073/Pnas.0900919106 |
0.413 |
|
| 2009 |
White M, Ross H, Levesque S, Whittom L, Pelletier GB, Racine N, Meloche S, Voisin L. Effects of angiotensin-converting enzyme inhibitor versus valsartan on cellular signaling events in heart transplant. The Annals of Pharmacotherapy. 43: 831-9. PMID 19417110 DOI: 10.1345/Aph.1L602 |
0.301 |
|
| 2009 |
Granados DP, Tanguay PL, Hardy MP, Caron E, de Verteuil D, Meloche S, Perreault C. ER stress affects processing of MHC class I-associated peptides. Bmc Immunology. 10: 10. PMID 19220912 DOI: 10.1186/1471-2172-10-10 |
0.753 |
|
| 2009 |
Gharib M, Marcantonio M, Lehmann SG, Courcelles M, Meloche S, Verreault A, Thibault P. Artifactual sulfation of silver-stained proteins: implications for the assignment of phosphorylation and sulfation sites. Molecular & Cellular Proteomics : McP. 8: 506-18. PMID 18936056 DOI: 10.1074/Mcp.M800327-Mcp200 |
0.386 |
|
| 2008 |
Clément JF, Meloche S, Servant MJ. The IKK-related kinases: from innate immunity to oncogenesis. Cell Research. 18: 889-99. PMID 19160540 DOI: 10.1038/Cr.2008.273 |
0.548 |
|
| 2008 |
Voisin L, Julien C, Duhamel S, Gopalbhai K, Claveau I, Saba-El-Leil MK, Rodrigue-Gervais IG, Gaboury L, Lamarre D, Basik M, Meloche S. Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. Bmc Cancer. 8: 337. PMID 19014680 DOI: 10.1186/1471-2407-8-337 |
0.774 |
|
| 2008 |
Déléris P, Rousseau J, Coulombe P, Rodier G, Tanguay PL, Meloche S. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. Journal of Cellular Physiology. 217: 778-88. PMID 18720373 DOI: 10.1002/Jcp.21560 |
0.849 |
|
| 2008 |
Culjkovic B, Tan K, Orolicki S, Amri A, Meloche S, Borden KLB. The eIF4E RNA regulon promotes the Akt signaling pathway Journal of Cell Biology. 181: 51-63. PMID 18391071 DOI: 10.1083/Jcb.200707018 |
0.56 |
|
| 2008 |
Clément JF, Bibeau-Poirier A, Gravel SP, Grandvaux N, Bonneil E, Thibault P, Meloche S, Servant MJ. Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. Journal of Virology. 82: 3984-96. PMID 18272581 DOI: 10.1128/Jvi.02526-07 |
0.537 |
|
| 2008 |
Rodier G, Coulombe P, Tanguay PL, Boutonnet C, Meloche S. Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase. The Embo Journal. 27: 679-91. PMID 18239684 DOI: 10.1038/Emboj.2008.6 |
0.836 |
|
| 2007 |
Purcell NH, Wilkins BJ, York A, Saba-El-Leil MK, Meloche S, Robbins J, Molkentin JD. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 14074-9. PMID 17709754 DOI: 10.1073/Pnas.0610906104 |
0.427 |
|
| 2007 |
Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, Smith A. FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development (Cambridge, England). 134: 2895-902. PMID 17660198 DOI: 10.1242/Dev.02880 |
0.432 |
|
| 2007 |
Meloche S, Pouysségur J. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene. 26: 3227-39. PMID 17496918 DOI: 10.1038/Sj.Onc.1210414 |
0.622 |
|
| 2007 |
Coulombe P, Meloche S. Atypical mitogen-activated protein kinases: structure, regulation and functions. Biochimica Et Biophysica Acta. 1773: 1376-87. PMID 17161475 DOI: 10.1016/J.Bbamcr.2006.11.001 |
0.566 |
|
| 2006 |
Bibeau-Poirier A, Gravel SP, Clément JF, Rolland S, Rodier G, Coulombe P, Hiscott J, Grandvaux N, Meloche S, Servant MJ. Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. Journal of Immunology (Baltimore, Md. : 1950). 177: 5059-67. PMID 17015689 DOI: 10.4049/Jimmunol.177.8.5059 |
0.449 |
|
| 2006 |
Aberg E, Perander M, Johansen B, Julien C, Meloche S, Keyse SM, Seternes OM. Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4. The Journal of Biological Chemistry. 281: 35499-510. PMID 16971392 DOI: 10.1074/Jbc.M606225200 |
0.846 |
|
| 2006 |
Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau M, Meloche S, Sauvageau G. E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells. Genes & Development. 20: 2110-20. PMID 16882984 DOI: 10.1101/Gad.1453406 |
0.371 |
|
| 2005 |
Martin NL, Saba-El-Leil MK, Sadekova S, Meloche S, Sauvageau G. EN2 is a candidate oncogene in human breast cancer. Oncogene. 24: 6890-901. PMID 16007149 DOI: 10.1038/Sj.Onc.1208840 |
0.302 |
|
| 2005 |
Pelletier S, Julien C, Popoff MR, Lamarche-Vane N, Meloche S. Cyclic AMP induces morphological changes of vascular smooth muscle cells by inhibiting a Rac-dependent signaling pathway. Journal of Cellular Physiology. 204: 412-22. PMID 15706595 DOI: 10.1002/Jcp.20308 |
0.809 |
|
| 2005 |
Rodier G, Makris C, Coulombe P, Scime A, Nakayama K, Nakayama KI, Meloche S. p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. The Journal of Cell Biology. 168: 55-66. PMID 15631990 DOI: 10.1083/Jcb.200404146 |
0.401 |
|
| 2004 |
Seternes OM, Mikalsen T, Johansen B, Michaelsen E, Armstrong CG, Morrice NA, Turgeon B, Meloche S, Moens U, Keyse SM. Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. The Embo Journal. 23: 4780-91. PMID 15577943 DOI: 10.1038/Sj.Emboj.7600489 |
0.627 |
|
| 2004 |
Coulombe P, Rodier G, Bonneil E, Thibault P, Meloche S. N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Molecular and Cellular Biology. 24: 6140-50. PMID 15226418 DOI: 10.1128/Mcb.24.14.6140-6150.2004 |
0.415 |
|
| 2004 |
Lips DJ, Bueno OF, Wilkins BJ, Purcell NH, Kaiser RA, Lorenz JN, Voisin L, Saba-El-Leil MK, Meloche S, Pouysségur J, Pagès G, De Windt LJ, Doevendans PA, Molkentin JD. MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation. 109: 1938-41. PMID 15096454 DOI: 10.1161/01.Cir.0000127126.73759.23 |
0.452 |
|
| 2004 |
Zhang D, Bar-Eli M, Meloche S, Brodt P. Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals. The Journal of Biological Chemistry. 279: 19683-90. PMID 14993222 DOI: 10.1074/Jbc.M313145200 |
0.527 |
|
| 2004 |
Meloche S, Vella FD, Voisin L, Ang SL, Saba-El-Leil M. Erk2 signaling and early embryo stem cell self-renewal. Cell Cycle (Georgetown, Tex.). 3: 241-3. PMID 14726711 |
0.359 |
|
| 2004 |
Chagraoui J, Niessen S, Lessard J, Girard S, Coulombe P, Meloche S, Sauvageau G. p120E4F-1: A Novel Candidate Factor for Mediating Bmi-1 Function in Hematopoietic Stem Cells. Blood. 104: 370-370. DOI: 10.1182/Blood.V104.11.370.370 |
0.375 |
|
| 2003 |
Wu C, Arcand M, Jansen G, Zhong M, Iouk T, Thomas DY, Meloche S, Whiteway M. Phosphorylation of the MAPKKK regulator Ste50p in Saccharomyces cerevisiae: a casein kinase I phosphorylation site is required for proper mating function. Eukaryotic Cell. 2: 949-61. PMID 14555477 DOI: 10.1128/Ec.2.5.949-961.2003 |
0.522 |
|
| 2003 |
Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL, Meloche S. An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. Embo Reports. 4: 964-8. PMID 14502223 DOI: 10.1038/Sj.Embor.Embor939 |
0.544 |
|
| 2003 |
Julien C, Coulombe P, Meloche S. Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression. The Journal of Biological Chemistry. 278: 42615-24. PMID 12915405 DOI: 10.1074/Jbc.M302724200 |
0.846 |
|
| 2003 |
Coulombe P, Rodier G, Pelletier S, Pellerin J, Meloche S. Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. Molecular and Cellular Biology. 23: 4542-58. PMID 12808096 DOI: 10.1128/Mcb.23.13.4542-4558.2003 |
0.787 |
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| 2003 |
Gingras B, Rodier G, Giasson E, Coulombe P, Chassagne C, Meloche S. Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression. Oncogene. 22: 2633-42. PMID 12730677 DOI: 10.1038/Sj.Onc.1206346 |
0.41 |
|
| 2003 |
Gennaro G, Ménard C, Giasson E, Michaud SE, Palasis M, Meloche S, Rivard A. Role of p44/p42 MAP kinase in the age-dependent increase in vascular smooth muscle cell proliferation and neointimal formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 204-10. PMID 12588760 DOI: 10.1161/01.Atv.0000053182.58636.Be |
0.449 |
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| 2003 |
Pelletier S, Duhamel F, Coulombe P, Popoff MR, Meloche S. Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Molecular and Cellular Biology. 23: 1316-33. PMID 12556491 DOI: 10.1128/Mcb.23.4.1316-1333.2003 |
0.769 |
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| 2003 |
Gopalbhai K, Jansen G, Beauregard G, Whiteway M, Dumas F, Wu C, Meloche S. Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1. The Journal of Biological Chemistry. 278: 8118-25. PMID 12506122 DOI: 10.1074/Jbc.M211870200 |
0.826 |
|
| 2002 |
Turgeon B, Lang BF, Meloche S. The protein kinase ERK3 is encoded by a single functional gene: genomic analysis of the ERK3 gene family. Genomics. 80: 673-80. PMID 12504858 DOI: 10.1006/Geno.2002.7013 |
0.509 |
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| 2002 |
Coulombe P, Meloche S. Dual-tag prokaryotic vectors for enhanced expression of full-length recombinant proteins. Analytical Biochemistry. 310: 219-22. PMID 12423642 DOI: 10.1016/S0003-2697(02)00319-6 |
0.354 |
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| 2002 |
Makris C, Voisin L, Giasson E, Tudan C, Kaplan DR, Meloche S. The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism. Oncogene. 21: 7891-6. PMID 12420226 DOI: 10.1038/Sj.Onc.1205964 |
0.493 |
|
| 2002 |
Voisin L, Foisy S, Giasson E, Lambert C, Moreau P, Meloche S. EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors. American Journal of Physiology. Cell Physiology. 283: C446-55. PMID 12107054 DOI: 10.1152/Ajpcell.00261.2001 |
0.464 |
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| 2002 |
Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, Meloche S. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. The Embo Journal. 20: 6672-82. PMID 11726503 DOI: 10.1093/Emboj/20.23.6672 |
0.438 |
|
| 2001 |
Charron F, Tsimiklis G, Arcand M, Robitaille L, Liang Q, Molkentin JD, Meloche S, Nemer M. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes & Development. 15: 2702-19. PMID 11641276 DOI: 10.1101/Gad.915701 |
0.46 |
|
| 2001 |
Rouleau JL, Kapuku G, Pelletier S, Gosselin H, Adam A, Gagnon C, Lambert C, Meloche S. Cardioprotective effects of ramipril and losartan in right ventricular pressure overload in the rabbit: importance of kinins and influence on angiotensin II type 1 receptor signaling pathway. Circulation. 104: 939-44. PMID 11514383 DOI: 10.1161/Hc3401.093149 |
0.649 |
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| 2000 |
Meloche S, Pelletier S, Servant MJ. Functional cross-talk between the cyclic AMP and Jak/STAT signaling pathways in vascular smooth muscle cells. Molecular and Cellular Biochemistry. 212: 99-109. PMID 11108141 DOI: 10.1023/A:1007140606333 |
0.668 |
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| 2000 |
Meloche S, Landry J, Huot J, Houle F, Marceau F, Giasson E. p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle. American Journal of Physiology. Heart and Circulatory Physiology. 279: H741-51. PMID 10924074 DOI: 10.1152/Ajpheart.2000.279.2.H741 |
0.475 |
|
| 2000 |
Yen L, You XL, Al Moustafa AE, Batist G, Hynes NE, Mader S, Meloche S, Alaoui-Jamali MA. Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis Oncogene. 19: 3460-3469. PMID 10918604 DOI: 10.1038/Sj.Onc.1203685 |
0.358 |
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| 2000 |
Meloche S, Gopalbhai K, Beatty BG, Scherer SW, Pellerin J. Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32. Cytogenetics and Cell Genetics. 88: 249-52. PMID 10828601 DOI: 10.1159/000015530 |
0.809 |
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| 2000 |
Servant MJ, Coulombe P, Turgeon B, Meloche S. Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms. The Journal of Cell Biology. 148: 543-56. PMID 10662779 DOI: 10.1083/Jcb.148.3.543 |
0.433 |
|
| 2000 |
Turgeon B, Saba-El-Leil MK, Meloche S. Cloning and characterization of mouse extracellular-signal-regulated protein kinase 3 as a unique gene product of 100 kDa. The Biochemical Journal. 346: 169-75. PMID 10657254 DOI: 10.1042/Bj3460169 |
0.514 |
|
| 1999 |
VOISIN L, LAROSE L, MELOCHE S. Angiotensin II stimulates serine phosphorylation of the adaptor protein Nck: physical association with the serine/threonine kinases Pak1 and casein kinase I Biochemical Journal. 341: 217-223. DOI: 10.1042/Bj3410217 |
0.558 |
|
| 1998 |
Csank C, Schröppel K, Leberer E, Harcus D, Mohamed O, Meloche S, Thomas DY, Whiteway M. Roles of the Candida aibicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis Infection and Immunity. 66: 2713-2721. PMID 9596738 DOI: 10.1128/Iai.66.6.2713-2721.1998 |
0.489 |
|
| 1998 |
Gopalbhai K, Meloche S. Repression of mitogen-activated protein kinases ERK1/ERK2 activity by a protein tyrosine phosphatase in rat fibroblasts transformed by upstream oncoproteins. Journal of Cellular Physiology. 174: 35-47. PMID 9397154 DOI: 10.1002/(Sici)1097-4652(199801)174:1<35::Aid-Jcp5>3.0.Co;2-H |
0.834 |
|
| 1997 |
Blais C, Drapeau G, Meloche S, Morais R, Adam A. Digoxigenin-labeled peptides for the immunological quantification of intracellular signaling proteins: application to the MAP kinase kinase isoform MEK2. Biotechniques. 23: 1098-103. PMID 9421643 DOI: 10.2144/97236Rr01 |
0.39 |
|
| 1997 |
Csank C, Makris C, Meloche S, Schröppel K, Röllinghoff M, Dignard D, Thomas DY, Whiteway M. Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans Molecular Biology of the Cell. 8: 2539-2551. PMID 9398674 DOI: 10.1091/Mbc.8.12.2539 |
0.53 |
|
| 1997 |
Giasson E, Servant MJ, Meloche S. Cyclic AMP-mediated inhibition of angiotensin II-induced protein synthesis is associated with suppression of tyrosine phosphorylation signaling in vascular smooth muscle cells. The Journal of Biological Chemistry. 272: 26879-86. PMID 9341120 DOI: 10.1074/Jbc.272.43.26879 |
0.499 |
|
| 1997 |
Scimeca JC, Servant MJ, Dyer JO, Meloche S. Essential role of calcium in the regulation of MAP kinase phosphatase-1 expression Oncogene. 15: 717-725. PMID 9264412 DOI: 10.1038/Sj.Onc.1201231 |
0.491 |
|
| 1997 |
Saba-el-Leil MK, Malo D, Meloche S. Chromosomal localization of the mouse genes encoding the ERK1 and ERK2 isoforms of MAP kinases. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 8: 141-2. PMID 9060415 DOI: 10.1007/S003359900374 |
0.449 |
|
| 1997 |
Fleurent M, Gingras AC, Sonenberg N, Meloche S. Angiotensin II stimulates phosphorylation of the translational repressor 4E-binding protein 1 by a mitogen-activated protein kinase-independent mechanism. The Journal of Biological Chemistry. 272: 4006-12. PMID 9020107 DOI: 10.1074/Jbc.272.7.4006 |
0.517 |
|
| 1996 |
Rajotte D, Sadowski HB, Haman A, Gopalbhai K, Meloche S, Liu L, Krystal G, Hoang T. Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor. Blood. 88: 2906-16. PMID 8874187 DOI: 10.1182/Blood.V88.8.2906.Bloodjournal8882906 |
0.794 |
|
| 1996 |
Servant MJ, Giasson E, Meloche S. Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells. The Journal of Biological Chemistry. 271: 16047-52. PMID 8663242 DOI: 10.1074/Jbc.271.27.16047 |
0.546 |
|
| 1996 |
Lin R, Beauparlant P, Makris C, Meloche S, Hiscott J. Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Molecular and Cellular Biology. 16: 1401-9. PMID 8657113 DOI: 10.1128/Mcb.16.4.1401 |
0.473 |
|
| 1996 |
Chassagne C, Servant M, Méloche S. Récepteurs de l'angiotensine II MéDecine/Sciences. 12: 1351. DOI: 10.4267/10608/677 |
0.304 |
|
| 1995 |
Leduc I, Meloche S. Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells. The Journal of Biological Chemistry. 270: 4401-4. PMID 7876204 DOI: 10.1074/Jbc.270.9.4401 |
0.537 |
|
| 1995 |
Meloche S. Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of p44mapk and p42mapk isoforms in the G1 phase and their inactivation at the G1/S transition. Journal of Cellular Physiology. 163: 577-88. PMID 7775600 DOI: 10.1002/Jcp.1041630319 |
0.468 |
|
| 1995 |
Giasson E, Meloche S. Role of p70 S6 protein kinase in angiotensin II-induced protein synthesis in vascular smooth muscle cells. The Journal of Biological Chemistry. 270: 5225-31. PMID 7534292 DOI: 10.1074/Jbc.270.10.5225 |
0.532 |
|
| 1993 |
Pagès G, Lenormand P, L'Allemain G, Chambard JC, Meloche S, Pouysségur J. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proceedings of the National Academy of Sciences of the United States of America. 90: 8319-23. PMID 8397401 DOI: 10.1073/pnas.90.18.8319 |
0.502 |
|
| 1992 |
Meloche S, Seuwen K, Pagès G, Pouysségur J. Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. Molecular Endocrinology (Baltimore, Md.). 6: 845-54. PMID 1603090 DOI: 10.1210/mend.6.5.1603090 |
0.395 |
|
| 1992 |
Meloche S, Pagès G, Pouysségur J. Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk. Molecular Biology of the Cell. 3: 63-71. PMID 1372523 DOI: 10.1091/mbc.3.1.63 |
0.505 |
|
| 1991 |
Ansotegui IJ, Chow SC, Jeddi-Tehrani M, Meloche S, Pawson A, Sekaly RP, Mak TW, Wigzell H. Characterization of a monoclonal antibody directed against the phosphotyrosine kinase p56(lck), in human T cells Scandinavian Journal of Immunology. 33: 375-380. PMID 2017663 DOI: 10.1111/j.1365-3083.1991.tb01784.x |
0.318 |
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