Arnim Pause - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Manteghi S, Gingras MC, Kharitidi D, Galarneau L, Marques M, Yan M, Cencic R, Robert F, Paquet M, Witcher M, Pelletier J, Pause A. Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer. Cell Reports. PMID 27210750 DOI: 10.1016/J.Celrep.2016.04.076  0.56
2016 Yan M, Audet-Walsh É, Manteghi S, Rosa Dufour C, Walker B, Baba M, St-Pierre J, Giguère V, Pause A. Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα. Genes & Development. 30: 1034-46. PMID 27151976 DOI: 10.1101/Gad.281410.116  0.56
2015 Vincent EE, Sergushichev A, Griss T, Gingras MC, Samborska B, Ntimbane T, Coelho PP, Blagih J, Raissi TC, Choinière L, Bridon G, Loginicheva E, Flynn BR, Thomas EC, Tavaré JM, ... ... Pause A, et al. Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. Molecular Cell. 60: 195-207. PMID 26474064 DOI: 10.1016/J.Molcel.2015.08.013  0.56
2015 Kharitidi D, Apaja PM, Manteghi S, Suzuki K, Malitskaya E, Roldan A, Gingras MC, Takagi J, Lukacs GL, Pause A. Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration. Cell Reports. 13: 599-609. PMID 26456826 DOI: 10.1016/J.Celrep.2015.09.024  0.56
2015 Possik E, Ajisebutu A, Manteghi S, Gingras MC, Vijayaraghavan T, Flamand M, Coull B, Schmeisser K, Duchaine T, van Steensel M, Hall DH, Pause A. FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores. Plos Genetics. 11: e1005520. PMID 26439621 DOI: 10.1371/Journal.Pgen.1005520  0.68
2015 Possik E, Pause A. Measuring oxidative stress resistance of Caenorhabditis elegans in 96-well microtiter plates. Journal of Visualized Experiments : Jove. e52746. PMID 25993260 DOI: 10.3791/52746  0.56
2014 Fonseca BD, Smith EM, Yelle N, Alain T, Bushell M, Pause A. The ever-evolving role of mTOR in translation. Seminars in Cell & Developmental Biology. 36: 102-12. PMID 25263010 DOI: 10.1016/J.Semcdb.2014.09.014  0.56
2014 Possik E, Jalali Z, Nouët Y, Yan M, Gingras MC, Schmeisser K, Panaite L, Dupuy F, Kharitidi D, Chotard L, Jones RG, Hall DH, Pause A. Folliculin regulates ampk-dependent autophagy and metabolic stress survival. Plos Genetics. 10: e1004273. PMID 24763318 DOI: 10.1371/Journal.Pgen.1004273  0.56
2014 Yan M, Gingras MC, Dunlop EA, Nouët Y, Dupuy F, Jalali Z, Possik E, Coull BJ, Kharitidi D, Dydensborg AB, Faubert B, Kamps M, Sabourin S, Preston RS, Davies DM, ... ... Pause A, et al. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. The Journal of Clinical Investigation. 124: 2640-50. PMID 24762438 DOI: 10.1172/Jci71749  0.56
2014 Kharitidi D, Manteghi S, Pause A. Pseudophosphatases: methods of analysis and physiological functions. Methods (San Diego, Calif.). 65: 207-18. PMID 24064037 DOI: 10.1016/J.Ymeth.2013.09.009  0.56
2014 MacParland SA, Bilodeau M, Grebely J, Bruneau J, Cooper C, Klein M, Sagan SM, Choucha N, Balfour L, Bialystok F, Krajden M, Raven J, Roberts E, Russell R, Houghton M, ... ... Pause A, et al. The 3rd Canadian symposium on Hepatitis c Virus: Expanding care in the interferon-free era Canadian Journal of Gastroenterology and Hepatology. 28: 481-487.  0.56
2013 Reaume MN, Graham GE, Tomiak E, Kamel-Reid S, Jewett MA, Bjarnason GA, Blais N, Care M, Drachenberg D, Gedye C, Grant R, Heng DY, Kapoor A, Kollmannsberger C, Lattouf JB, ... ... Pause A, et al. Canadian guideline on genetic screening for hereditary renal cell cancers. Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada. 7: 319-23. PMID 24319509 DOI: 10.5489/Cuaj.1496  0.56
2013 Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, et al. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metabolism. 18: 698-711. PMID 24206664 DOI: 10.1016/J.Cmet.2013.10.001  0.56
2013 Tee AR, Pause A. Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin. Familial Cancer. 12: 367-72. PMID 23096221 DOI: 10.1007/S10689-012-9576-9  0.56
2012 Uniacke J, Holterman CE, Lachance G, Franovic A, Jacob MD, Fabian MR, Payette J, Holcik M, Pause A, Lee S. An oxygen-regulated switch in the protein synthesis machinery. Nature. 486: 126-9. PMID 22678294 DOI: 10.1038/Nature11055  0.56
2012 Jonasch E, Futreal PA, Davis IJ, Bailey ST, Kim WY, Brugarolas J, Giaccia AJ, Kurban G, Pause A, Frydman J, Zurita AJ, Rini BI, Sharma P, Atkins MB, Walker CL, et al. State of the science: an update on renal cell carcinoma. Molecular Cancer Research : McR. 10: 859-80. PMID 22638109 DOI: 10.1158/1541-7786.Mcr-12-0117  0.56
2011 Tedbury P, Welbourn S, Pause A, King B, Griffin S, Harris M. The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein. The Journal of General Virology. 92: 819-30. PMID 21177929 DOI: 10.1099/Vir.0.027441-0  0.56
2011 Preston RS, Philp A, Claessens T, Gijezen L, Dydensborg AB, Dunlop EA, Harper KT, Brinkhuizen T, Menko FH, Davies DM, Land SC, Pause A, Baar K, van Steensel MA, Tee AR. Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene. 30: 1159-73. PMID 21057536 DOI: 10.1038/Onc.2010.497  0.56
2010 De Schutter JW, Zaretsky S, Welbourn S, Pause A, Tsantrizos YS. Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase. Bioorganic & Medicinal Chemistry Letters. 20: 5781-6. PMID 20801032 DOI: 10.1016/J.Bmcl.2010.07.133  0.56
2010 Hudon V, Sabourin S, Dydensborg AB, Kottis V, Ghazi A, Paquet M, Crosby K, Pomerleau V, Uetani N, Pause A. Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin. Journal of Medical Genetics. 47: 182-9. PMID 19843504 DOI: 10.1136/Jmg.2009.072009  0.56
2009 Gingras MC, Kharitidi D, Chénard V, Uetani N, Bouchard M, Tremblay ML, Pause A. Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP). The International Journal of Developmental Biology. 53: 1069-74. PMID 19378249 DOI: 10.1387/Ijdb.082820Mg  0.56
2009 Gingras MC, Zhang YL, Kharitidi D, Barr AJ, Knapp S, Tremblay ML, Pause A. HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. Plos One. 4: e5105. PMID 19340315 DOI: 10.1371/Journal.Pone.0005105  0.56
2009 Welbourn S, Jirasko V, Breton V, Reiss S, Penin F, Bartenschlager R, Pause A. Investigation of a role for lysine residues in non-structural proteins 2 and 2/3 of the hepatitis C virus for their degradation and virus assembly. The Journal of General Virology. 90: 1071-80. PMID 19264595 DOI: 10.1099/Vir.0.009944-0  0.56
2009 Welbourn S, Pause A. HCV NS2/3 protease: A future antiviral drug target? Future Virology. 4: 463-472. DOI: 10.2217/Fvl.09.29  0.56
2008 Khacho M, Mekhail K, Pilon-Larose K, Pause A, Côté J, Lee S. eEF1A is a novel component of the mammalian nuclear protein export machinery. Molecular Biology of the Cell. 19: 5296-308. PMID 18799616 DOI: 10.1091/Mbc.E08-06-0562  0.56
2008 Kurban G, Duplan E, Ramlal N, Hudon V, Sado Y, Ninomiya Y, Pause A. Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2. Oncogene. 27: 1004-12. PMID 17700531 DOI: 10.1038/Sj.Onc.1210709  0.56
2007 Dormoy-Raclet V, Ménard I, Clair E, Kurban G, Mazroui R, Di Marco S, von Roretz C, Pause A, Gallouzi IE. The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner. Molecular and Cellular Biology. 27: 5365-80. PMID 17548472 DOI: 10.1128/Mcb.00113-07  0.56
2007 Welbourn S, Pause A. The hepatitis C virus NS2/3 protease. Current Issues in Molecular Biology. 9: 63-9. PMID 17263146  0.56
2006 Sonenberg N, Pause A. Signal transduction. Protein synthesis and oncogenesis meet again. Science (New York, N.Y.). 314: 428-9. PMID 17053135 DOI: 10.1126/Science.1134031  0.56
2006 Franovic A, Robert I, Smith K, Kurban G, Pause A, Gunaratnam L, Lee S. Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Cancer Research. 66: 8083-90. PMID 16912185 DOI: 10.1158/0008-5472.Can-06-1595  0.56
2006 Kurban G, Hudon V, Duplan E, Ohh M, Pause A. Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Research. 66: 1313-9. PMID 16452184 DOI: 10.1158/0008-5472.Can-05-2560  0.56
2005 Welbourn S, Green R, Gamache I, Dandache S, Lohmann V, Bartenschlager R, Meerovitch K, Pause A. Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication. The Journal of Biological Chemistry. 280: 29604-11. PMID 15980068 DOI: 10.1074/Jbc.M505019200  0.56
2005 Svitkin YV, Pause A, Lopez-Lastra M, Perreault S, Sonenberg N. Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3. Journal of Virology. 79: 6868-81. PMID 15890926 DOI: 10.1128/Jvi.79.11.6868-6881.2005  0.56
2003 Pause A, Kukolj G, Bailey M, Brault M, Dô F, Halmos T, Lagacé L, Maurice R, Marquis M, McKercher G, Pellerin C, Pilote L, Thibeault D, Lamarre D. An NS3 serine protease inhibitor abrogates replication of subgenomic hepatitis C virus RNA. The Journal of Biological Chemistry. 278: 20374-80. PMID 12646587 DOI: 10.1074/jbc.M210785200  0.56
2002 Tan SL, Pause A, Shi Y, Sonenberg N. Hepatitis C therapeutics: current status and emerging strategies. Nature Reviews. Drug Discovery. 1: 867-81. PMID 12415247 DOI: 10.1038/Nrd937  0.56
2002 Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proceedings of the National Academy of Sciences of the United States of America. 99: 10353-8. PMID 12149480 DOI: 10.1073/Pnas.162424199  0.56
2001 Thibeault D, Maurice R, Pilote L, Lamarre D, Pause A. In vitro characterization of a purified NS2/3 protease variant of hepatitis C virus. The Journal of Biological Chemistry. 276: 46678-84. PMID 11591719 DOI: 10.1074/jbc.M108266200  0.56
2001 Svitkin YV, Pause A, Haghighat A, Pyronnet S, Witherell G, Belsham GJ, Sonenberg N. The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. Rna (New York, N.Y.). 7: 382-94. PMID 11333019 DOI: 10.1017/S135583820100108X  0.56
2001 de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A, Lee S. Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 1387-92. PMID 11171960 DOI: 10.1073/Pnas.031587498  0.56
2000 Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. The Embo Journal. 19: 3142-56. PMID 10856257 DOI: 10.1093/Emboj/19.12.3142  0.56
1999 Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A. Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences of the United States of America. 96: 12436-41. PMID 10535940 DOI: 10.1073/Pnas.96.22.12436  0.56
1999 Pause A, Peterson B, Schaffar G, Stearman R, Klausner RD. Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein. Proceedings of the National Academy of Sciences of the United States of America. 96: 9533-8. PMID 10449727 DOI: 10.1073/Pnas.96.17.9533  0.56
1999 Liakopoulos D, Büsgen T, Brychzy A, Jentsch S, Pause A. Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function. Proceedings of the National Academy of Sciences of the United States of America. 96: 5510-5. PMID 10318914 DOI: 10.1073/Pnas.96.10.5510  0.56
1999 Lee S, Neumann M, Stearman R, Stauber R, Pause A, Pavlakis GN, Klausner RD. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Molecular and Cellular Biology. 19: 1486-97. PMID 9891082 DOI: 10.1128/Mcb.19.2.1486  0.56
1998 Pause A, Lee S, Lonergan KM, Klausner RD. The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proceedings of the National Academy of Sciences of the United States of America. 95: 993-8. PMID 9448273 DOI: 10.1073/Pnas.95.3.993  0.56
1997 Takagi Y, Pause A, Conaway RC, Conaway JW. Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein. The Journal of Biological Chemistry. 272: 27444-9. PMID 9341197 DOI: 10.1074/Jbc.272.43.27444  0.56
1997 Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proceedings of the National Academy of Sciences of the United States of America. 94: 2156-61. PMID 9122164 DOI: 10.1073/Pnas.94.6.2156  0.56
1996 Rousseau D, Gingras AC, Pause A, Sonenberg N. The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth. Oncogene. 13: 2415-20. PMID 8957083  0.56
1996 Pause A, Aso T, Linehan WM, Conaway JW, Conaway RC, Klausner RD. Interaction of von Hippel-Lindau tumor suppressor gene product with elongin. Methods in Enzymology. 274: 436-41. PMID 8902823 DOI: 10.1016/S0076-6879(96)74035-1  0.56
1996 Gingras AC, Svitkin Y, Belsham GJ, Pause A, Sonenberg N. Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proceedings of the National Academy of Sciences of the United States of America. 93: 5578-83. PMID 8643618 DOI: 10.1073/Pnas.93.11.5578  0.56
1996 Gnarra JR, Duan DR, Weng Y, Humphrey JS, Chen DY, Lee S, Pause A, Dudley CF, Latif F, Kuzmin I, Schmidt L, Duh FM, Stackhouse T, Chen F, Kishida T, et al. Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma. Biochimica Et Biophysica Acta. 1242: 201-10. PMID 8603073 DOI: 10.1016/0304-419X(95)00012-5  0.56
1995 Haghighat A, Mader S, Pause A, Sonenberg N. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. The Embo Journal. 14: 5701-9. PMID 8521827 DOI: 10.1002/J.1460-2075.1995.Tb00257.X  0.56
1995 Duan DR, Pause A, Burgess WH, Aso T, Chen DY, Garrett KP, Conaway RC, Conaway JW, Linehan WM, Klausner RD. Inhibition of transcription elongation by the VHL tumor suppressor protein. Science (New York, N.Y.). 269: 1402-6. PMID 7660122 DOI: 10.1126/Science.7660122  0.56
1995 Mader S, Lee H, Pause A, Sonenberg N. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Molecular and Cellular Biology. 15: 4990-7. PMID 7651417 DOI: 10.1128/Mcb.15.9.4990  0.56
1994 Méthot N, Pause A, Hershey JW, Sonenberg N. The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence. Molecular and Cellular Biology. 14: 2307-16. PMID 8139536 DOI: 10.1128/Mcb.14.4.2307  0.56
1994 Pause A, Méthot N, Svitkin Y, Merrick WC, Sonenberg N. Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation. The Embo Journal. 13: 1205-15. PMID 8131750 DOI: 10.1002/J.1460-2075.1994.Tb06370.X  0.56
1994 Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N, Lawrence JC. PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science (New York, N.Y.). 266: 653-6. PMID 7939721 DOI: 10.1126/Science.7939721  0.56
1994 Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature. 371: 762-7. PMID 7935836 DOI: 10.1038/371762A0  0.56
1994 Svitkin YV, Pause A, Sonenberg N. La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA. Journal of Virology. 68: 7001-7. PMID 7933082 DOI: 10.1128/Jvi.68.11.7001-7007.1994  0.56
1993 Yoder-Hill J, Pause A, Sonenberg N, Merrick WC. The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A. The Journal of Biological Chemistry. 268: 5566-73. PMID 8449919  0.56
1993 Pause A, Méthot N, Sonenberg N. The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Molecular and Cellular Biology. 13: 6789-98. PMID 8413273 DOI: 10.1128/Mcb.13.11.6789  0.56
1993 Pause A, Sonenberg N. Helicases and RNA unwinding in translation. Current opinion in structural biology 1993, 3: 953-959 Current Opinion in Structural Biology. 3: 953-959. DOI: 10.1016/0959-440X(93)90161-D  0.56
1992 Blum S, Schmid SR, Pause A, Buser P, Linder P, Sonenberg N, Trachsel H. ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 89: 7664-8. PMID 1502180  0.56
1992 Pause A, Sonenberg N. Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. The Embo Journal. 11: 2643-54. PMID 1378397 DOI: 10.1002/J.1460-2075.1992.Tb05330.X  0.56
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