| Year |
Citation |
Score |
| 2024 |
Pherwani S, Connolly D, Sun Q, Karwi QG, Carr M, Ho KL, Wagg CS, Zhang L, Levasseur J, Silver H, Dyck JRB, Lopaschuk GD. Ketones provide an extra source of fuel for the failing heart without impairing glucose oxidation. Metabolism: Clinical and Experimental. 154: 155818. PMID 38369056 DOI: 10.1016/j.metabol.2024.155818 |
0.512 |
|
| 2024 |
Sun Q, Güven B, Wagg CS, de Oliveira AA, Silver H, Zhang L, Chen B, Wei K, Ketema E, Karwi QG, Persad KL, Vu J, Wang F, Dyck JRB, Oudit GY, ... Lopaschuk GD, et al. Mitochondrial fatty acid oxidation is the major source of cardiac ATP production in heart failure with preserved ejection fraction. Cardiovascular Research. PMID 38193548 DOI: 10.1093/cvr/cvae006 |
0.465 |
|
| 2024 |
Cho S, Dadson K, Sung HK, Ayansola O, Mirzaesmaeili A, Noskovicova N, Zhao Y, Cheung K, Radisic M, Hinz B, Sater AAA, Hsu HH, Lopaschuk GD, Sweeney G. Cardioprotection by the adiponectin receptor agonist ALY688 in a preclinical mouse model of heart failure with reduced ejection fraction (HFrEF). Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 171: 116119. PMID 38181714 DOI: 10.1016/j.biopha.2023.116119 |
0.31 |
|
| 2024 |
Güven B, Sun Q, Wagg CS, Almeida de Oliveira A, Silver H, Persad KL, Onay-Besikci A, Vu J, Oudit GY, Lopaschuk GD. Obesity Is a Major Determinant of Impaired Cardiac Energy Metabolism in Heart Failure with Preserved Ejection Fraction. The Journal of Pharmacology and Experimental Therapeutics. 388: 145-155. PMID 37977817 DOI: 10.1124/jpet.123.001791 |
0.774 |
|
| 2023 |
Sun Q, Wagg CS, Güven B, Wei K, de Oliveira AA, Silver H, Zhang L, Vergara A, Chen B, Wong N, Wang F, Dyck JRB, Oudit GY, Lopaschuk GD. Stimulating cardiac glucose oxidation lessens the severity of heart failure in aged female mice. Basic Research in Cardiology. PMID 38148348 DOI: 10.1007/s00395-023-01020-2 |
0.543 |
|
| 2023 |
Lopaschuk GD, Karwi QG. Jump Starting the Heart: Ketone Esters Improve Cardiac Function in Patients With Cardiogenic Shock. Jacc. Heart Failure. 11: 1348-1350. PMID 37452807 DOI: 10.1016/j.jchf.2023.06.006 |
0.343 |
|
| 2023 |
Lopaschuk GD, Persad KL. Failure to Launch: Impaired Cardiac Mitochondrial Metabolic Development in Newborns With Single Ventricle Heart Failure. Jacc. Basic to Translational Science. 8: 280-282. PMID 37034282 DOI: 10.1016/j.jacbts.2023.01.017 |
0.366 |
|
| 2023 |
Gopal K, Karwi QG, Tabatabaei Dakhili SA, Wagg CS, Zhang L, Sun Q, Saed CT, Panidarapu S, Perfetti R, Ramasamy R, Ussher JR, Lopaschuk GD. Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation. Cardiovascular Diabetology. 22: 73. PMID 36978133 DOI: 10.1186/s12933-023-01811-w |
0.368 |
|
| 2022 |
Hall AR, Karwi QG, Kumar S, Dongworth R, Aksentijević D, Altamimi TR, Fridianto KT, Chinda K, Hernandez-Resendiz S, Mahmood MU, Michelakis E, Ramachandra CJ, Ching J, Vicencio JM, Shattock MJ, ... ... Lopaschuk G, et al. Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation. Scientific Reports. 12: 20551. PMID 36446868 DOI: 10.1038/s41598-022-23847-w |
0.774 |
|
| 2022 |
Persad KL, Lopaschuk GD. Energy Metabolism on Mitochondrial Maturation and Its Effects on Cardiomyocyte Cell Fate. Frontiers in Cell and Developmental Biology. 10: 886393. PMID 35865630 DOI: 10.3389/fcell.2022.886393 |
0.349 |
|
| 2022 |
Lopaschuk GD, Hess DA, Verma S. Ketones regulate endothelial homeostasis. Cell Metabolism. 34: 513-515. PMID 35385704 DOI: 10.1016/j.cmet.2022.03.008 |
0.309 |
|
| 2022 |
Karwi QG, Lopaschuk GD. Branched-Chain Amino Acid Metabolism in the Failing Heart. Cardiovascular Drugs and Therapy. PMID 35150384 DOI: 10.1007/s10557-022-07320-4 |
0.531 |
|
| 2022 |
Ho KL, Karwi QG, Connolly D, Pherwani S, Ketema EB, Ussher JR, Lopaschuk GD. Metabolic, structural and biochemical changes in diabetes and the development of heart failure. Diabetologia. 65: 411-423. PMID 34994805 DOI: 10.1007/s00125-021-05637-7 |
0.39 |
|
| 2021 |
Karwi QG, Sun Q, Lopaschuk GD. The Contribution of Cardiac Fatty Acid Oxidation to Diabetic Cardiomyopathy Severity. Cells. 10. PMID 34831481 DOI: 10.3390/cells10113259 |
0.444 |
|
| 2021 |
Uddin GM, Karwi QG, Pherwani S, Gopal K, Wagg CS, Biswas D, Atnasious M, Wu Y, Wu G, Zhang L, Ho KL, Pulinilkunnil T, Ussher JR, Lopaschuk GD. Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart. Metabolism: Clinical and Experimental. 154871. PMID 34478752 DOI: 10.1016/j.metabol.2021.154871 |
0.452 |
|
| 2021 |
Ketema EB, Lopaschuk GD. Post-translational Acetylation Control of Cardiac Energy Metabolism. Frontiers in Cardiovascular Medicine. 8: 723996. PMID 34409084 DOI: 10.3389/fcvm.2021.723996 |
0.344 |
|
| 2021 |
Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED. Cardiac Energy Metabolism in Heart Failure. Circulation Research. 128: 1487-1513. PMID 33983836 DOI: 10.1161/CIRCRESAHA.121.318241 |
0.547 |
|
| 2021 |
Greenwell AA, Gopal K, Altamimi T, Saed CT, Wang F, Tabatabaei-Dakhili SA, Ho KL, Zhang L, Eaton F, Kruger JL, Al Batran R, Lopaschuk GD, Oudit GY, Ussher JR. Barth Syndrome-Related Cardiomyopathy is Associated with a Reduction in Myocardial Glucose Oxidation. American Journal of Physiology. Heart and Circulatory Physiology. PMID 33929899 DOI: 10.1152/ajpheart.00873.2020 |
0.537 |
|
| 2021 |
Cai Y, Liu H, Song E, Wang L, Xu J, He Y, Zhang D, Zhang L, Cheng KK, Jin L, Wu M, Liu S, Qi D, Zhang L, Lopaschuk GD, et al. Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice p53/PPARα signaling. Theranostics. 11: 4710-4727. PMID 33754023 DOI: 10.7150/thno.51739 |
0.37 |
|
| 2020 |
Karwi QG, Wagg CS, Altamimi TR, Uddin GM, Ho KL, Darwesh AM, Seubert JM, Lopaschuk GD. Insulin directly stimulates mitochondrial glucose oxidation in the heart. Cardiovascular Diabetology. 19: 207. PMID 33287820 DOI: 10.1186/s12933-020-01177-3 |
0.351 |
|
| 2020 |
Lopaschuk GD, Karwi QG, Ho KL, Pherwani S, Ketema EB. KETONE METABOLISM IN THE FAILING HEART. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 158813. PMID 32920139 DOI: 10.1016/j.bbalip.2020.158813 |
0.521 |
|
| 2020 |
Groenendyk J, Wang Q, Wagg C, Lee D, Robinson A, Barr A, Light PE, Lopaschuk GD, Agellon LB, Michalak M. Selective enhancement of cardiomyocyte efficiency results in a pernicious heart condition. Plos One. 15: e0236457. PMID 32790682 DOI: 10.1371/Journal.Pone.0236457 |
0.459 |
|
| 2020 |
Lopaschuk GD, Verma S. Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: A State-of-the-Art Review. Jacc. Basic to Translational Science. 5: 632-644. PMID 32613148 DOI: 10.1016/j.jacbts.2020.02.004 |
0.395 |
|
| 2020 |
Karwi QG, Biswas D, Pulinilkunnil T, Lopaschuk GD. Myocardial Ketones Metabolism in Heart Failure: Karwi et al. Role of ketone in heart failure. Journal of Cardiac Failure. PMID 32442517 DOI: 10.1016/j.cardfail.2020.04.005 |
0.407 |
|
| 2020 |
Ho KL, Karwi QG, Wagg C, Zhang L, Vo K, Altamimi T, Uddin GM, Ussher JR, Lopaschuk GD. Ketones can become the major fuel source for the heart but do not increase cardiac efficiency. Cardiovascular Research. PMID 32402081 DOI: 10.1093/cvr/cvaa143 |
0.428 |
|
| 2020 |
Karwi Q, Uddin GM, Wagg CS, Lopaschuk GD. Abstract MP125: Branched-chain Keto Acids, Not Branched-chain Amino Acids, Impairs Cardiac Insulin Sensitivity by Disrupting Insulin Signaling in the Mitochondria Circulation Research. 127. DOI: 10.1161/res.127.suppl_1.mp125 |
0.453 |
|
| 2019 |
Wang W, Zhang L, Battiprolu PK, Fukushima A, Nguyen K, Milner K, Gupta A, Altamimi T, Byrne N, Mori J, Alrob OA, Wagg C, Fillmore N, Wang SH, Liu DM, ... ... Lopaschuk GD, et al. Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction. Jacc. Basic to Translational Science. 4: 385-400. PMID 31312761 DOI: 10.1016/j.jacbts.2019.02.003 |
0.549 |
|
| 2019 |
Uddin GM, Zhang L, Shah S, Fukushima A, Wagg CS, Gopal K, Al Batran R, Pherwani S, Ho KL, Boisvenue J, Karwi QG, Altamimi T, Wishart DS, Dyck JRB, Ussher JR, ... ... Lopaschuk GD, et al. Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure. Cardiovascular Diabetology. 18: 86. PMID 31277657 DOI: 10.1186/s12933-019-0892-3 |
0.469 |
|
| 2019 |
Karwi QG, Jörg AR, Lopaschuk GD. Allosteric, transcriptional and post-translational control of mitochondrial energy metabolism. The Biochemical Journal. 476: 1695-1712. PMID 31217327 DOI: 10.1042/BCJ20180617 |
0.425 |
|
| 2019 |
Altamimi TR, Gao S, Karwi QG, Fukushima A, Rawat S, Wagg CS, Zhang L, Lopaschuk GD. Adropin Regulates Cardiac Energy Metabolism and Improves Cardiac Function and Efficiency. Metabolism: Clinical and Experimental. PMID 31202835 DOI: 10.1016/J.Metabol.2019.06.005 |
0.436 |
|
| 2019 |
Marzilli M, Vineareanu D, Lopaschuk G, Chen Y, Dalal JJ, Danchin N, Etriby E, Ferrari R, Gowdak LH, Lopatin Y, Milicic D, Parkhomenko A, Pinto F, Ponikowski P, Seferovic P, et al. Trimetazidine in cardiovascular medicine. International Journal of Cardiology. PMID 31178223 DOI: 10.1016/J.Ijcard.2019.05.063 |
0.556 |
|
| 2019 |
Karwi QG, Zhang L, Altamimi TR, Wagg CS, Patel V, Uddin GM, Joerg AR, Padwal RS, Johnstone DE, Sharma A, Oudit GY, Lopaschuk GD. Weight Loss Enhances Cardiac Energy Metabolism and Function in Heart Failure Associated with Obesity. Diabetes, Obesity & Metabolism. PMID 31050157 DOI: 10.1111/dom.13762 |
0.43 |
|
| 2019 |
Ho KL, Zhang L, Wagg C, Batran RA, Gopal K, Levasseur J, Leone T, Dyck JRB, Ussher JR, Muoio DM, Kelly DP, Lopaschuk GD. Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency. Cardiovascular Research. PMID 30778524 DOI: 10.1093/Cvr/Cvz045 |
0.448 |
|
| 2019 |
Karwi QG, Zhang L, Wagg CS, Wang W, Ghandi M, Thai D, Yan H, Ussher JR, Oudit GY, Lopaschuk GD. Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction. Cardiovascular Diabetology. 18: 1. PMID 30626440 DOI: 10.1186/s12933-019-0806-4 |
0.396 |
|
| 2019 |
Altamimi TR, Karwi QG, Uddin GM, Fukushima A, Kwong JQ, Molkentin JD, Lopaschuk GD. Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve. Journal of Molecular and Cellular Cardiology. 127: 223-231. PMID 30615880 DOI: 10.1016/J.Yjmcc.2018.12.019 |
0.528 |
|
| 2019 |
Uddin GM, Pherwani S, Wagg CS, Gopal K, Batran RA, Zhang L, Wu Y, Hussaini N, Rawat S, Ussher JR, Lopaschuk GD. Abstract 868: A Cardiac Specific Branched Chain Aminotransferase Deletion Increases Insulin Stimulated Glucose Oxidation in the Mouse Heart Circulation Research. 125. DOI: 10.1161/res.125.suppl_1.868 |
0.446 |
|
| 2019 |
Karwi QG, Wagg CS, Altamimi TR, Lopaschuk GD. Abstract 856: Mitochondrial Protein Kinase B (akt) Translocation Mediates Insulin-stimulated Cardiac Glucose Oxidation Circulation Research. 125. DOI: 10.1161/res.125.suppl_1.856 |
0.33 |
|
| 2018 |
Verma S, Rawat S, Ho KL, Wagg CS, Zhang L, Teoh H, Dyck JE, Uddin GM, Oudit GY, Mayoux E, Lehrke M, Marx N, Lopaschuk GD. Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors. Jacc. Basic to Translational Science. 3: 575-587. PMID 30456329 DOI: 10.1016/j.jacbts.2018.07.006 |
0.52 |
|
| 2018 |
Altamimi TR, Chowdhury B, Singh KK, Zhang L, Mahmood MU, Pan Y, Quan A, Teoh H, Verma S, Lopaschuk GD. A novel role of endothelial autophagy as a regulator of myocardial fatty acid oxidation. The Journal of Thoracic and Cardiovascular Surgery. PMID 30195591 DOI: 10.1016/j.jtcvs.2018.07.047 |
0.39 |
|
| 2018 |
Fillmore N, Levasseur JL, Fukushima A, Wagg CS, Wang W, Dyck JRB, Lopaschuk GD. Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction. Molecular Medicine (Cambridge, Mass.). 24: 3. PMID 30134787 DOI: 10.1186/s10020-018-0005-x |
0.467 |
|
| 2018 |
Fillmore N, Wagg CS, Zhang L, Fukushima A, Lopaschuk GD. Cardiac Branched-Chain Amino Acid Oxidation is Reduced During Insulin Resistance in the Heart. American Journal of Physiology. Endocrinology and Metabolism. PMID 30106622 DOI: 10.1152/ajpendo.00097.2018 |
0.493 |
|
| 2018 |
Karwi QG, Uddin GM, Ho KL, Lopaschuk GD. Loss of Metabolic Flexibility in the Failing Heart. Frontiers in Cardiovascular Medicine. 5: 68. PMID 29928647 DOI: 10.3389/fcvm.2018.00068 |
0.559 |
|
| 2018 |
Fukushima A, Zhang L, Huqi A, Lam VH, Rawat S, Altamimi T, Wagg CS, Dhaliwal KK, Hornberger LK, Kantor PF, Rebeyka IM, Lopaschuk GD. Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism. Jci Insight. 3. PMID 29769443 DOI: 10.1172/jci.insight.99239 |
0.524 |
|
| 2018 |
De Jong KA, Barrand S, Wood-Bradley RJ, de Almeida DL, Czeczor JK, Lopaschuk GD, Armitage JA, McGee SL. Maternal high fat diet induces early cardiac hypertrophy and alters cardiac metabolism in Sprague Dawley rat offspring. Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd. PMID 29691147 DOI: 10.1016/j.numecd.2018.02.019 |
0.392 |
|
| 2018 |
van Weeghel M, Abdurrachim D, Nederlof R, Argmann CA, Houtkooper RH, Hagen J, Nabben M, Denis S, Ciapaite J, Kolwicz SC, Lopaschuk GD, Auwerx J, Nicolay K, Des Rosiers C, Wanders RJ, et al. Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B. Cardiovascular Research. PMID 29635338 DOI: 10.1093/cvr/cvy089 |
0.497 |
|
| 2018 |
Uddin GM, Ho KL, Lopaschuk GD. Treading slowly through hypoxic waters - dichloroacetate to the rescue! The Journal of Physiology. PMID 29451305 DOI: 10.1113/JP275898 |
0.302 |
|
| 2018 |
Altamimi TR, Thomas PD, Darwesh AM, Fillmore N, Mahmoud MU, Zhang L, Gupta A, Batran RA, Seubert JM, Lopaschuk G. Cytosolic Carnitine Acetyltransferase as a Source of Cytosolic Acetyl-CoA: A Possible Mechanism for Regulation of Cardiac Energy Metabolism. The Biochemical Journal. PMID 29438065 DOI: 10.1042/BCJ20170823 |
0.49 |
|
| 2018 |
Verma S, Rawat S, Ho K, Wagg C, Zhang L, Oudit G, Marx N, Mayoux E, Lopaschuk GD. P1267Empagliflozin prevention of heart failure development in diabetes is associated with an improvement in cardiac energy producition European Heart Journal. 39. DOI: 10.1093/EURHEARTJ/EHY565.P1267 |
0.316 |
|
| 2018 |
Moellmann J, Haj-Yehia E, Maxeiner S, Schuett K, Lopaschuk GD, Verma S, Mayoux E, Lehrke M, Marx N. P1266Empagliflozin improves left ventricular diastolic function in db/db mice without altering cardiac expression of enzymes relevant for ketone body or branched chain amino acid catabolism European Heart Journal. 39. DOI: 10.1093/EURHEARTJ/EHY565.P1266 |
0.322 |
|
| 2018 |
Ho K, Zhang L, Wagg C, Gopal K, Levasseur J, Leone T, Dyck J, Ussher J, Muoio D, Kelly D, Lopaschuk G. Increasing fatty acid oxidation in the failing heart does not improve cardiac function Journal of Molecular and Cellular Cardiology. 124: 113-114. DOI: 10.1016/J.Yjmcc.2018.07.091 |
0.593 |
|
| 2018 |
Karwi QG, Zhang L, Gupta A, Fukushima A, Patel V, Alrob OA, Altamimi T, Wagg CS, Padwal RS, Johnstone DE, Sharma AM, Oudit GY, Lopaschuk GD. Caloric restriction limits fatty acid oxidation and improves cardiac function in heart failure associated with obesity Journal of Molecular and Cellular Cardiology. 124: 99. DOI: 10.1016/J.YJMCC.2018.07.053 |
0.456 |
|
| 2018 |
Rawat S, Fukushima A, Zhang L, Huqi A, Lam V, Altamimi T, Wagg C, Petinelli R, Dhaliwal K, Hornberger L, Kantor P, Rebeyka I, Lopaschuk G. Control of cardiac fatty acid metabolism in infants with hypoplastic left heart syndrome Journal of Molecular and Cellular Cardiology. 124: 91-92. DOI: 10.1016/J.Yjmcc.2018.07.032 |
0.497 |
|
| 2017 |
Ussher JR, Lopaschuk GD. Decreased Maternal Cardiac Glucose Oxidation: Taking One for the Fetus. Circulation Research. 121: 1299-1301. PMID 29217705 DOI: 10.1161/CIRCRESAHA.117.312098 |
0.44 |
|
| 2017 |
De Jong KA, Lopaschuk GD. Complex Energy Metabolic Changes in Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction. The Canadian Journal of Cardiology. PMID 28579160 DOI: 10.1016/j.cjca.2017.03.009 |
0.552 |
|
| 2017 |
Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, et al. Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nature Communications. 8: 14095. PMID 28117339 DOI: 10.1038/Ncomms14095 |
0.437 |
|
| 2017 |
Ho K, Wagg C, Zhang L, Ussher J, Lopaschuk G. The contribution of fatty acid and ketone body oxidation to energy production increases in the failing heart and is associated with a decrease in cardiac efficiency Journal of Molecular and Cellular Cardiology. 112: 143. DOI: 10.1016/J.Yjmcc.2017.07.041 |
0.561 |
|
| 2017 |
Rawat S, Fukushima A, Zhang L, Huqi A, Altamimi T, Wagg C, Hornberger L, Kantor P, Rebeyka I, Lopaschuk G. Cardiac hypertrophy suppresses glucose oxidation in newborns with congenital heart defects Journal of Molecular and Cellular Cardiology. 112: 138. DOI: 10.1016/J.Yjmcc.2017.07.026 |
0.572 |
|
| 2017 |
Ahmadi A, Renaud J, Petryk J, Hadizad T, Ruddy T, Dyck J, Beanlands R, deKemp R, Lopaschuk G, Mielniczuk L. INHIBITION OF FATTY ACID OXIDATION IS ASSOCIATED WITH IMPROVED RIGHT VENTRICULAR FUNCTION AND METABOLISM IN TWO RAT MODELS OF PULMONARY ARTERIAL HYPERTENSION Canadian Journal of Cardiology. 33: S167-S168. DOI: 10.1016/J.Cjca.2017.07.326 |
0.408 |
|
| 2016 |
Lopaschuk GD. Metabolic Modulators in Heart Disease: Past, Present, and Future. The Canadian Journal of Cardiology. PMID 28279520 DOI: 10.1016/j.cjca.2016.12.013 |
0.301 |
|
| 2016 |
Lopaschuk GD. Fatty Acid Oxidation and Its Relation with Insulin Resistance and Associated Disorders. Annals of Nutrition & Metabolism. 68: 15-20. PMID 27931032 DOI: 10.1159/000448357 |
0.481 |
|
| 2016 |
Fukushima A, Lopaschuk GD. Acetylation control of cardiac fatty acid β-oxidation and energy metabolism in obesity, diabetes, and heart failure. Biochimica Et Biophysica Acta. PMID 27479696 DOI: 10.1016/j.bbadis.2016.07.020 |
0.494 |
|
| 2016 |
Groenendyk J, Lee D, Jung J, Dyck JR, Lopaschuk GD, Agellon LB, Michalak M. Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. Plos One. 11: e0159682. PMID 27441395 DOI: 10.1371/Journal.Pone.0159682 |
0.313 |
|
| 2016 |
Fukushima A, Alrob OA, Zhang L, Wagg CS, Altamimi T, Rawat S, Rebeyka IM, Kantor PF, Lopaschuk GD. Acetylation and Succinylation Contribute to Maturational Alterations in Energy Metabolism in the Newborn Heart. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00900.2015. PMID 27261364 DOI: 10.1152/ajpheart.00900.2015 |
0.503 |
|
| 2016 |
Lopaschuk GD. Preface to the BBA special issue "heart lipid metabolism". Biochimica Et Biophysica Acta. PMID 27208401 DOI: 10.1016/j.bbalip.2016.05.007 |
0.343 |
|
| 2016 |
Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, et al. Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circulation Research. 118: 1659-701. PMID 27012580 DOI: 10.1161/Res.0000000000000097 |
0.336 |
|
| 2016 |
Fukushima A, Lopaschuk GD. Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes. Biochimica Et Biophysica Acta. PMID 26996746 DOI: 10.1016/j.bbalip.2016.03.020 |
0.511 |
|
| 2016 |
Lopatin YM, Rosano GM, Fragasso G, Lopaschuk GD, Seferovic PM, Gowdak LH, Vinereanu D, Hamid MA, Jourdain P, Ponikowski P. Rationale and benefits of trimetazidine by acting on cardiac metabolism in heart failure. International Journal of Cardiology. 203: 909-15. PMID 26618252 DOI: 10.1016/j.ijcard.2015.11.060 |
0.45 |
|
| 2016 |
Fukushima A, Huqi A, Zhang L, Lam VH, Altamimi T, Kinugawa S, Tsutsui H, Rebeyka IM, Kantor PF, Lopaschuk GD. Cardiac Hypertrophy in Neonates With Congenital Heart Disease Delays Maturational Alterations in Cardiac Energy Metabolism by Modifying Myocardial Acetylation Control Journal of Cardiac Failure. 22: S230-S231. DOI: 10.1016/J.CARDFAIL.2016.07.413 |
0.407 |
|
| 2016 |
Fukushima A, Alrob OA, Zhang L, Wagg CS, Altamimi T, Kinugawa S, Tsutsui H, Rebeyka IM, Kantor PF, Lopaschuk GD. Acetylation Control Contributes to Maturational Alterations in Cardiac Energy Metabolism in the Newborn Heart Journal of Cardiac Failure. 22: S199. DOI: 10.1016/J.CARDFAIL.2016.07.249 |
0.404 |
|
| 2015 |
Azam MA, Wagg CS, Massé S, Farid T, Lai PF, Kusha M, Asta J, Jaimes R, Kuzmiak-Glancy S, Kay MW, Lopaschuk GD, Nanthakumar K. Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF. American Journal of Physiology. Heart and Circulatory Physiology. 309: H1543-53. PMID 26342067 DOI: 10.1152/Ajpheart.00404.2015 |
0.523 |
|
| 2015 |
Patel VB, Mori J, McLean BA, Basu R, Das SK, Ramprasath T, Parajuli N, Penninger JM, Grant MB, Lopaschuk GD, Oudit GY. ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity. Diabetes. PMID 26224885 DOI: 10.2337/Db15-0399 |
0.344 |
|
| 2015 |
Fukushima A, Milner K, Gupta A, Lopaschuk GD. Myocardial Energy Substrate Metabolism in Heart Failure : from Pathways to Therapeutic Targets. Current Pharmaceutical Design. 21: 3654-64. PMID 26166604 |
0.575 |
|
| 2015 |
Masoud WG, Abo Al-Rob O, Yang Y, Lopaschuk GD, Clanachan AS. Tolerance to ischemic injury in remodeled mouse hearts: less ischemic glycogenolysis and preserved metabolic efficiency. Cardiovascular Research. PMID 26150203 DOI: 10.1093/cvr/cvv195 |
0.357 |
|
| 2015 |
Sankaralingam S, Lopaschuk GD. Cardiac energy metabolic alterations in pressure overload-induced left and right heart failure (2013 Grover Conference Series). Pulmonary Circulation. 5: 15-28. PMID 25992268 DOI: 10.1086/679608 |
0.478 |
|
| 2015 |
Lam VH, Zhang L, Huqi A, Fukushima A, Tanner BA, Onay-Besikci A, Keung W, Kantor PF, Jaswal JS, Rebeyka IM, Lopaschuk GD. Activating PPARα Prevents Post-Ischemic Contractile Dysfunction in Hypertrophied Neonatal Hearts. Circulation Research. 117: 41-51. PMID 25977309 DOI: 10.1161/Circresaha.117.306585 |
0.76 |
|
| 2015 |
Mohamed IA, Gadeau AP, Fliegel L, Lopaschuk G, Mlih M, Abdulrahman N, Fillmore N, Mraiche F. Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy. Plos One. 10: e0123318. PMID 25884410 DOI: 10.1371/Journal.Pone.0123318 |
0.317 |
|
| 2015 |
Gao S, McMillan RP, Zhu Q, Lopaschuk GD, Hulver MW, Butler AA. Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance. Molecular Metabolism. 4: 310-24. PMID 25830094 DOI: 10.1016/J.Molmet.2015.01.005 |
0.332 |
|
| 2015 |
Fillmore N, Huqi A, Jaswal JS, Mori J, Paulin R, Haromy A, Onay-Besikci A, Ionescu L, Thébaud B, Michelakis E, Lopaschuk GD. Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival. Plos One. 10: e0120257. PMID 25768019 DOI: 10.1371/journal.pone.0120257 |
0.713 |
|
| 2015 |
Sankaralingam S, Abo Alrob O, Zhang L, Jaswal JS, Wagg CS, Fukushima A, Padwal RS, Johnstone DE, Sharma AM, Lopaschuk GD. Lowering body weight in obese mice with diastolic heart failure improves cardiac insulin sensitivity and function: implications for the obesity paradox. Diabetes. 64: 1643-57. PMID 25524917 DOI: 10.2337/db14-1050 |
0.35 |
|
| 2015 |
Wang W, Zhang L, Wagg C, Alrob O, Fillmore N, Wang S, Dyck J, Lopaschuk G. OPTIMIZATION OF CARDIAC ENERGY METABOLISM BY MALONYL COA DECARBOXYLASE INHIBITOR IMPROVES CARDIAC FUNCTION POST MYOCARDIAL INFARCTION IN RATS Canadian Journal of Cardiology. 31: S303. DOI: 10.1016/j.cjca.2015.07.624 |
0.355 |
|
| 2015 |
Ahmadi A, Renaud J, Petryk J, Hadizad T, Ruddy T, Dyck J, Beanlands R, deKemp R, Lopaschuk G, Mielniczuk L. FATTY ACID OXIDATION INHIBITION AS A POTENTIAL NOVEL TREATMENT STRATEGY IN PULMONARY ARTERY HYPERTENSION AND RIGHT HEART FAILURE Canadian Journal of Cardiology. 31: S65. DOI: 10.1016/j.cjca.2015.07.150 |
0.341 |
|
| 2014 |
Wu R, Chang HC, Khechaduri A, Chawla K, Tran M, Chai X, Wagg C, Ghanefar M, Jiang X, Bayeva M, Gonzalez F, Lopaschuk G, Ardehali H. Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy. The Journal of Clinical Investigation. 124: 4795-806. PMID 25329697 DOI: 10.1172/Jci76737 |
0.506 |
|
| 2014 |
Fillmore N, Lopaschuk GD. The link between pediatric heart failure and mitochondrial lipids. Journal of Molecular and Cellular Cardiology. 76: 71-2. PMID 25123339 DOI: 10.1016/j.yjmcc.2014.08.002 |
0.302 |
|
| 2014 |
Abo Alrob O, Lopaschuk GD. Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation. Biochemical Society Transactions. 42: 1043-51. PMID 25110000 DOI: 10.1042/BST20140094 |
0.523 |
|
| 2014 |
Aksentijević D, McAndrew DJ, Karlstädt A, Zervou S, Sebag-Montefiore L, Cross R, Douglas G, Regitz-Zagrosek V, Lopaschuk GD, Neubauer S, Lygate CA. Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity. Journal of Molecular and Cellular Cardiology. 75: 76-87. PMID 25066696 DOI: 10.1016/J.Yjmcc.2014.07.008 |
0.756 |
|
| 2014 |
Ussher JR, Fillmore N, Keung W, Mori J, Beker DL, Wagg CS, Jaswal JS, Lopaschuk GD. Trimetazidine therapy prevents obesity-induced cardiomyopathy in mice. The Canadian Journal of Cardiology. 30: 940-4. PMID 25064584 DOI: 10.1016/j.cjca.2014.04.023 |
0.331 |
|
| 2014 |
Ezekowitz JA, Becher H, Belenkie I, Clark AM, Duff HJ, Friedrich MG, Haykowsky MJ, Howlett JG, Kassiri Z, Kaul P, Kim DH, Knudtson ML, Light PE, Lopaschuk GD, McAlister FA, et al. The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study. Bmc Cardiovascular Disorders. 14: 91. PMID 25063541 DOI: 10.1186/1471-2261-14-91 |
0.31 |
|
| 2014 |
Alrob OA, Sankaralingam S, Ma C, Wagg CS, Fillmore N, Jaswal JS, Sack MN, Lehner R, Gupta MP, Michelakis ED, Padwal RS, Johnstone DE, Sharma AM, Lopaschuk GD. Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling. Cardiovascular Research. 103: 485-97. PMID 24966184 DOI: 10.1093/cvr/cvu156 |
0.475 |
|
| 2014 |
Gao S, McMillan RP, Jacas J, Zhu Q, Li X, Kumar GK, Casals N, Hegardt FG, Robbins PD, Lopaschuk GD, Hulver MW, Butler AA. Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin. Diabetes. 63: 3242-52. PMID 24848071 DOI: 10.2337/Db14-0388 |
0.349 |
|
| 2014 |
Heusch G, Libby P, Gersh B, Yellon D, Böhm M, Lopaschuk G, Opie L. Cardiovascular remodelling in coronary artery disease and heart failure. Lancet (London, England). 383: 1933-43. PMID 24831770 DOI: 10.1016/S0140-6736(14)60107-0 |
0.314 |
|
| 2014 |
Lee CT, Ussher JR, Mohammad A, Lam A, Lopaschuk GD. 5'-AMP-activated protein kinase increases glucose uptake independent of GLUT4 translocation in cardiac myocytes. Canadian Journal of Physiology and Pharmacology. 92: 307-14. PMID 24708213 DOI: 10.1139/cjpp-2013-0107 |
0.364 |
|
| 2014 |
Ussher JR, Keung W, Fillmore N, Koves TR, Mori J, Zhang L, Lopaschuk DG, Ilkayeva OR, Wagg CS, Jaswal JS, Muoio DM, Lopaschuk GD. Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice. The Journal of Pharmacology and Experimental Therapeutics. 349: 487-96. PMID 24700885 DOI: 10.1124/Jpet.114.214197 |
0.385 |
|
| 2014 |
Fillmore N, Lopaschuk GD. Malonyl CoA: A promising target for the treatment of cardiac disease. Iubmb Life. PMID 24591219 DOI: 10.1002/iub.1253 |
0.504 |
|
| 2014 |
Fillmore N, Mori J, Lopaschuk GD. Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy. British Journal of Pharmacology. 171: 2080-90. PMID 24147975 DOI: 10.1111/bph.12475 |
0.566 |
|
| 2014 |
Masoud WG, Ussher JR, Wang W, Jaswal JS, Wagg CS, Dyck JR, Lygate CA, Neubauer S, Clanachan AS, Lopaschuk GD. Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation. Cardiovascular Research. 101: 30-8. PMID 24048945 DOI: 10.1093/cvr/cvt216 |
0.444 |
|
| 2014 |
Aksentijevic D, Medway DJ, Sebag-Montefiore L, Zervou S, Douglas G, Lopaschuk GD, Neubauer S, Lygate CA. Metabolic Inflexibility of Malonyl CoA Decarboxylase (MCD) Knockout Mice Leads to Cardiac Remodelling and High Mortality During Peri-Weaning Period Biophysical Journal. 106: 187a. DOI: 10.1016/J.Bpj.2013.11.1054 |
0.381 |
|
| 2013 |
Zhang L, Yu X, Cheypesh A, Rebeyka IM, Granoski D, Lopaschuk GD, Li J. Plasma fatty acid levels in children during extracorporeal membrane oxygenation support--a pilot study. The Journal of Extra-Corporeal Technology. 45: 242-7. PMID 24649572 |
0.318 |
|
| 2013 |
Mori J, Zhang L, Oudit GY, Lopaschuk GD. Impact of the renin-angiotensin system on cardiac energy metabolism in heart failure. Journal of Molecular and Cellular Cardiology. 63: 98-106. PMID 23886814 DOI: 10.1016/j.yjmcc.2013.07.010 |
0.379 |
|
| 2013 |
Zhang L, Jaswal JS, Ussher JR, Sankaralingam S, Wagg C, Zaugg M, Lopaschuk GD. Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy. Circulation. Heart Failure. 6: 1039-48. PMID 23861485 DOI: 10.1161/CIRCHEARTFAILURE.112.000228 |
0.415 |
|
| 2013 |
Gao S, Casals N, Keung W, Moran TH, Lopaschuk GD. Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei. Physiology & Behavior. 118: 165-70. PMID 23680429 DOI: 10.1016/J.Physbeh.2013.03.030 |
0.322 |
|
| 2013 |
Lee D, Oka T, Hunter B, Robinson A, Papp S, Nakamura K, Srisakuldee W, Nickel BE, Light PE, Dyck JR, Lopaschuk GD, Kardami E, Opas M, Michalak M. Calreticulin induces dilated cardiomyopathy. Plos One. 8: e56387. PMID 23437120 DOI: 10.1371/Journal.Pone.0056387 |
0.332 |
|
| 2013 |
Mori J, Alrob OA, Wagg CS, Harris RA, Lopaschuk GD, Oudit GY. ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4. American Journal of Physiology. Heart and Circulatory Physiology. 304: H1103-13. PMID 23396452 DOI: 10.1152/Ajpheart.00636.2012 |
0.371 |
|
| 2013 |
Gill RS, Lee TF, Manouchehri N, Liu JQ, Lopaschuk G, Bigam DL, Cheung PY. Postresuscitation cyclosporine treatment attenuates myocardial and cardiac mitochondrial injury in newborn piglets with asphyxia-reoxygenation. Critical Care Medicine. 41: 1069-74. PMID 23385100 DOI: 10.1097/Ccm.0B013E3182746704 |
0.406 |
|
| 2013 |
Singh KK, Shukla PC, Yanagawa B, Quan A, Lovren F, Pan Y, Wagg CS, Teoh H, Lopaschuk GD, Verma S. Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1. The Journal of Thoracic and Cardiovascular Surgery. 146: 702-9. PMID 23317938 DOI: 10.1016/J.Cjca.2013.07.344 |
0.443 |
|
| 2013 |
Zhabyeyev P, Gandhi M, Mori J, Basu R, Kassiri Z, Clanachan A, Lopaschuk GD, Oudit GY. Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload. Cardiovascular Research. 97: 676-85. PMID 23257023 DOI: 10.1093/cvr/cvs424 |
0.39 |
|
| 2013 |
Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, Morrow E, Kutty S, Lopaschuk GD, Archer SL. FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. Journal of Molecular Medicine (Berlin, Germany). 91: 333-46. PMID 23247844 DOI: 10.1007/S00109-012-0982-0 |
0.404 |
|
| 2013 |
Keung W, Ussher JR, Jaswal JS, Raubenheimer M, Lam VH, Wagg CS, Lopaschuk GD. Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice. Diabetes. 62: 711-20. PMID 23139350 DOI: 10.2337/db12-0259 |
0.318 |
|
| 2013 |
Lewandowski ED, Fischer SK, Fasano M, Banke NH, Walker LA, Huqi A, Wang X, Lopaschuk GD, O'Donnell JM. Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy. Circulation Research. 112: 57-65. PMID 22982985 DOI: 10.1161/CIRCRESAHA.112.274456 |
0.431 |
|
| 2013 |
Fillmore N, Lopaschuk GD. Targeting mitochondrial oxidative metabolism as an approach to treat heart failure. Biochimica Et Biophysica Acta. 1833: 857-65. PMID 22960640 DOI: 10.1016/j.bbamcr.2012.08.014 |
0.508 |
|
| 2013 |
Huqi A, Jaswal J, Perry R, Lam V, Jhangri GS, Rebeyka IM, Lopaschuk GD. Newborns with congenital heart disease and reactive myocardial hypertrophy display altered cardiac energy metabolism and reduced post-surgical functional recovery European Heart Journal. 34: P2140-P2140. DOI: 10.1093/EURHEARTJ/EHT308.P2140 |
0.415 |
|
| 2013 |
Huai A, Jaswal J, Lam V, Rebeyka IR, Lopaschuk GD. CARDIAC HYPERTROPHY IN HUMAN NEWBORNS WITH CONGENITAL HEART DISEASE MODIFIES MATURATIONAL CHANGES IN CARDIAC ENERGY METABOLISM AND NEGATIVELY AFFECTS POSTSURGICAL FUNCTIONAL RECOVERY. Journal of the American College of Cardiology. 61: E461. DOI: 10.1016/S0735-1097(13)60461-1 |
0.381 |
|
| 2012 |
Ussher JR, Jaswal JS, Lopaschuk GD. Pyridine nucleotide regulation of cardiac intermediary metabolism. Circulation Research. 111: 628-41. PMID 22904042 DOI: 10.1161/CIRCRESAHA.111.246371 |
0.526 |
|
| 2012 |
Wu G, Zhang L, Li T, Lopaschuk G, Vance DE, Jacobs RL. Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice. Journal of Obesity. 2012: 319172. PMID 22778916 DOI: 10.1155/2012/319172 |
0.348 |
|
| 2012 |
Mori J, Basu R, McLean BA, Das SK, Zhang L, Patel VB, Wagg CS, Kassiri Z, Lopaschuk GD, Oudit GY. Agonist-induced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: a metabolic contribution to heart failure with normal ejection fraction. Circulation. Heart Failure. 5: 493-503. PMID 22705769 DOI: 10.1161/CIRCHEARTFAILURE.112.966705 |
0.395 |
|
| 2012 |
Ussher JR, Folmes CD, Keung W, Fillmore N, Jaswal JS, Cadete VJ, Beker DL, Lam VH, Zhang L, Lopaschuk GD. Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance. Plos One. 7: e37703. PMID 22629445 DOI: 10.1371/journal.pone.0037703 |
0.361 |
|
| 2012 |
Zhang L, Mori J, Wagg C, Lopaschuk GD. Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding. Febs Letters. 586: 996-1003. PMID 22569253 DOI: 10.1016/j.febslet.2012.02.027 |
0.317 |
|
| 2012 |
Ussher JR, Wang W, Gandhi M, Keung W, Samokhvalov V, Oka T, Wagg CS, Jaswal JS, Harris RA, Clanachan AS, Dyck JR, Lopaschuk GD. Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury. Cardiovascular Research. 94: 359-69. PMID 22436846 DOI: 10.1093/Cvr/Cvs129 |
0.491 |
|
| 2012 |
Oka T, Lam VH, Zhang L, Keung W, Cadete VJ, Samokhvalov V, Tanner BA, Beker DL, Ussher JR, Huqi A, Jaswal JS, Rebeyka IM, Lopaschuk GD. Cardiac hypertrophy in the newborn delays the maturation of fatty acid β-oxidation and compromises postischemic functional recovery. American Journal of Physiology. Heart and Circulatory Physiology. 302: H1784-94. PMID 22408020 DOI: 10.1152/ajpheart.00804.2011 |
0.555 |
|
| 2012 |
Axelsen LN, Keung W, Pedersen HD, Meier E, Riber D, Kjølbye AL, Petersen JS, Proctor SD, Holstein-Rathlou NH, Lopaschuk GD. Glucagon and a glucagon-GLP-1 dual-agonist increases cardiac performance with different metabolic effects in insulin-resistant hearts. British Journal of Pharmacology. 165: 2736-48. PMID 22014161 DOI: 10.1111/j.1476-5381.2011.01714.x |
0.377 |
|
| 2012 |
Piao L, Sidhu VK, Fang Y, Thenappan T, Lopaschuk G, Archer S. CHRONIC INHIBITION OF PYRUVATE DEHYDROGENASE KINASE WITH DICHLOROACETATE, IMPROVES CARDIAC METABOLISM AND FUNCTION IN RIGHT VENTRICULAR HYPERTROPHY IN FAWN-HOODED RATS Journal of the American College of Cardiology. 59: E1604. DOI: 10.1016/S0735-1097(12)61605-2 |
0.413 |
|
| 2012 |
Azam M, Wagg C, Massé S, Farid T, Lai P, Kusha M, Asta J, Lopaschuk G, Nanthakumar K. 467 Metabolic Modulation for the Management of Cardiac Systolic Dysfunction Following Ventricular Fibrillation Resuscitation Canadian Journal of Cardiology. 28: S271. DOI: 10.1016/j.cjca.2012.07.429 |
0.318 |
|
| 2011 |
Nagoshi T, Yoshimura M, Rosano GM, Lopaschuk GD, Mochizuki S. Optimization of cardiac metabolism in heart failure. Current Pharmaceutical Design. 17: 3846-53. PMID 21933140 |
0.383 |
|
| 2011 |
Kudej RK, Fasano M, Zhao X, Lopaschuk GD, Fischer SK, Vatner DE, Vatner SF, Lewandowski ED. Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia. Cardiovascular Research. 92: 394-400. PMID 21835931 DOI: 10.1093/cvr/cvr215 |
0.38 |
|
| 2011 |
Lucchinetti E, Wang L, Ko KW, Troxler H, Hersberger M, Zhang L, Omar MA, Lopaschuk GD, Clanachan AS, Zaugg M. Enhanced glucose uptake via GLUT4 fuels recovery from calcium overload after ischaemia-reperfusion injury in sevoflurane- but not propofol-treated hearts. British Journal of Anaesthesia. 106: 792-800. PMID 21474475 DOI: 10.1093/bja/aer065 |
0.536 |
|
| 2011 |
Chambers KT, Leone TC, Sambandam N, Kovacs A, Wagg CS, Lopaschuk GD, Finck BN, Kelly DP. Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response. The Journal of Biological Chemistry. 286: 11155-62. PMID 21321124 DOI: 10.1074/Jbc.M110.217349 |
0.475 |
|
| 2011 |
Jaswal JS, Keung W, Wang W, Ussher JR, Lopaschuk GD. Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart. Biochimica Et Biophysica Acta. 1813: 1333-50. PMID 21256164 DOI: 10.1016/j.bbamcr.2011.01.015 |
0.592 |
|
| 2011 |
Rueda-Clausen CF, Morton JS, Lopaschuk GD, Davidge ST. Long-term effects of intrauterine growth restriction on cardiac metabolism and susceptibility to ischaemia/reperfusion. Cardiovascular Research. 90: 285-94. PMID 21097804 DOI: 10.1093/cvr/cvq363 |
0.314 |
|
| 2011 |
Keung W, Cadete VJ, Palaniyappan A, Jablonski A, Fischer M, Lopaschuk GD. Intracerebroventricular leptin administration differentially alters cardiac energy metabolism in mice fed a low-fat and high-fat diet. Journal of Cardiovascular Pharmacology. 57: 103-13. PMID 20980918 DOI: 10.1097/FJC.0b013e31820014f9 |
0.354 |
|
| 2011 |
Mraiche F, Wagg CS, Lopaschuk GD, Fliegel L. Elevated levels of activated NHE1 protect the myocardium and improve metabolism following ischemia/reperfusion injury. Journal of Molecular and Cellular Cardiology. 50: 157-64. PMID 20974148 DOI: 10.1016/j.yjmcc.2010.10.016 |
0.468 |
|
| 2011 |
Zhang L, Ussher JR, Oka T, Cadete VJ, Wagg C, Lopaschuk GD. Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation. Cardiovascular Research. 89: 148-56. PMID 20729341 DOI: 10.1093/cvr/cvq266 |
0.324 |
|
| 2010 |
Wang L, Ko KW, Lucchinetti E, Zhang L, Troxler H, Hersberger M, Omar MA, Posse de Chaves EI, Lopaschuk GD, Clanachan AS, Zaugg M. Metabolic profiling of hearts exposed to sevoflurane and propofol reveals distinct regulation of fatty acid and glucose oxidation: CD36 and pyruvate dehydrogenase as key regulators in anesthetic-induced fuel shift. Anesthesiology. 113: 541-51. PMID 20683255 DOI: 10.1097/ALN.0b013e3181e2c1a1 |
0.46 |
|
| 2010 |
Kandalam V, Basu R, Abraham T, Wang X, Awad A, Wang W, Lopaschuk GD, Maeda N, Oudit GY, Kassiri Z. Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction. American Journal of Physiology. Heart and Circulatory Physiology. 299: H1012-23. PMID 20675565 DOI: 10.1152/Ajpheart.00246.2010 |
0.306 |
|
| 2010 |
Folmes CD, Sawicki G, Cadete VJ, Masson G, Barr AJ, Lopaschuk GD. Novel O-palmitolylated beta-E1 subunit of pyruvate dehydrogenase is phosphorylated during ischemia/reperfusion injury. Proteome Science. 8: 38. PMID 20618950 DOI: 10.1186/1477-5956-8-38 |
0.449 |
|
| 2010 |
Lopaschuk GD, Jaswal JS. Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation. Journal of Cardiovascular Pharmacology. 56: 130-40. PMID 20505524 DOI: 10.1097/FJC.0b013e3181e74a14 |
0.442 |
|
| 2010 |
Jessen N, Koh HJ, Folmes CD, Wagg C, Fujii N, Løfgren B, Wolf CM, Berul CI, Hirshman MF, Lopaschuk GD, Goodyear LJ. Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function. Biochimica Et Biophysica Acta. 1802: 593-600. PMID 20441792 DOI: 10.1016/j.bbadis.2010.04.008 |
0.448 |
|
| 2010 |
Ito M, Jaswal JS, Lam VH, Oka T, Zhang L, Beker DL, Lopaschuk GD, Rebeyka IM. High levels of fatty acids increase contractile function of neonatal rabbit hearts during reperfusion following ischemia. American Journal of Physiology. Heart and Circulatory Physiology. 298: H1426-37. PMID 20154256 DOI: 10.1152/ajpheart.00284.2009 |
0.497 |
|
| 2010 |
Carvalho RA, Sousa RP, Cadete VJ, Lopaschuk GD, Palmeira CM, Bjork JA, Wallace KB. Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy. Toxicology. 270: 92-8. PMID 20132857 DOI: 10.1016/J.Tox.2010.01.019 |
0.519 |
|
| 2010 |
Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. Myocardial fatty acid metabolism in health and disease. Physiological Reviews. 90: 207-58. PMID 20086077 DOI: 10.1152/physrev.00015.2009 |
0.467 |
|
| 2010 |
Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, Toth PT, Marsboom G, Zhang HJ, Haber I, Rehman J, Lopaschuk GD, Archer SL. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle. Journal of Molecular Medicine (Berlin, Germany). 88: 47-60. PMID 19949938 DOI: 10.1007/S00109-009-0524-6 |
0.381 |
|
| 2010 |
Zhang L, Keung W, Samokhvalov V, Wang W, Lopaschuk GD. Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle. Biochimica Et Biophysica Acta. 1801: 1-22. PMID 19782765 DOI: 10.1016/j.bbalip.2009.09.014 |
0.394 |
|
| 2009 |
Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z. Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. American Journal of Physiology. Heart and Circulatory Physiology. 297: H2096-108. PMID 19801494 DOI: 10.1152/ajpheart.00452.2009 |
0.392 |
|
| 2009 |
Ussher JR, Koves TR, Jaswal JS, Zhang L, Ilkayeva O, Dyck JR, Muoio DM, Lopaschuk GD. Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. Diabetes. 58: 1766-75. PMID 19478144 DOI: 10.2337/Db09-0011 |
0.472 |
|
| 2009 |
Yan J, Young ME, Cui L, Lopaschuk GD, Liao R, Tian R. Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity. Circulation. 119: 2818-28. PMID 19451348 DOI: 10.1161/CIRCULATIONAHA.108.832915 |
0.492 |
|
| 2009 |
Folmes CD, Wagg CS, Shen M, Clanachan AS, Tian R, Lopaschuk GD. Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts. American Journal of Physiology. Heart and Circulatory Physiology. 297: H313-21. PMID 19429810 DOI: 10.1152/ajpheart.01298.2008 |
0.547 |
|
| 2009 |
Folmes CD, Sowah D, Clanachan AS, Lopaschuk GD. High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency. Journal of Molecular and Cellular Cardiology. 47: 142-8. PMID 19303418 DOI: 10.1016/j.yjmcc.2009.03.005 |
0.501 |
|
| 2009 |
Ussher JR, Lopaschuk GD. Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion. Basic Research in Cardiology. 104: 203-10. PMID 19242641 DOI: 10.1007/s00395-009-0003-9 |
0.551 |
|
| 2009 |
Lopaschuk GD. AMP-activated protein kinase control of energy metabolism in the ischemic heart. International Journal of Obesity (2005). S29-35. PMID 18719595 DOI: 10.1038/ijo.2008.120 |
0.528 |
|
| 2008 |
Yatscoff MA, Jaswal JS, Grant MR, Greenwood R, Lukat T, Beker DL, Rebeyka IM, Lopaschuk GD. Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart Pediatric Research. 64: 643-647. PMID 18614968 DOI: 10.1203/PDR.0b013e318184d281 |
0.475 |
|
| 2008 |
Fert-Bober J, Sawicki G, Lopaschuk GD, Cheung PY. Proteomic analysis of cardiac metabolic enzymes in asphyxiated newborn piglets. Molecular and Cellular Biochemistry. 318: 13-21. PMID 18607691 DOI: 10.1007/s11010-008-9852-z |
0.365 |
|
| 2008 |
Khairallah RJ, Khairallah M, Gélinas R, Bouchard B, Young ME, Allen BG, Lopaschuk GD, Deschepper CF, Des Rosiers C. Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation. Journal of Molecular and Cellular Cardiology. 45: 230-9. PMID 18590915 DOI: 10.1016/J.Yjmcc.2008.05.012 |
0.47 |
|
| 2008 |
Ussher JR, Lopaschuk GD. The malonyl CoA axis as a potential target for treating ischaemic heart disease. Cardiovascular Research. 79: 259-68. PMID 18499682 DOI: 10.1093/cvr/cvn130 |
0.503 |
|
| 2008 |
Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metabolism. 7: 45-56. PMID 18177724 DOI: 10.1016/J.Cmet.2007.10.013 |
0.32 |
|
| 2008 |
Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, Stanley WC. Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation. American Journal of Physiology. Heart and Circulatory Physiology. 294: H954-60. PMID 18083904 DOI: 10.1152/Ajpheart.00557.2007 |
0.494 |
|
| 2008 |
Wang W, Lopaschuk GD. Metabolic therapy for the treatment of ischemic heart disease: reality and expectations. Expert Review of Cardiovascular Therapy. 5: 1123-34. PMID 18035928 DOI: 10.1586/14779072.5.6.1123 |
0.51 |
|
| 2008 |
Taha M, Lopaschuk GD. Alterations in energy metabolism in cardiomyopathies. Annals of Medicine. 39: 594-607. PMID 17934906 DOI: 10.1080/07853890701618305 |
0.412 |
|
| 2007 |
Lopaschuk GD, Folmes CD, Stanley WC. Cardiac energy metabolism in obesity. Circulation Research. 101: 335-47. PMID 17702980 DOI: 10.1161/CIRCRESAHA.107.150417 |
0.339 |
|
| 2007 |
Carley AN, Atkinson LL, Bonen A, Harper ME, Kunnathu S, Lopaschuk GD, Severson DL. Mechanisms responsible for enhanced fatty acid utilization by perfused hearts from type 2 diabetic db/db mice. Archives of Physiology and Biochemistry. 113: 65-75. PMID 17558605 DOI: 10.1080/13813450701422617 |
0.409 |
|
| 2007 |
Onay-Besikci A, Wagg C, Lopaschuk TP, Keung W, Lopaschuk GD. Alpha-lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts. Basic Research in Cardiology. 102: 436-44. PMID 17530314 DOI: 10.1007/S00395-007-0661-4 |
0.775 |
|
| 2007 |
Lam A, Lopaschuk GD. Anti-anginal effects of partial fatty acid oxidation inhibitors. Current Opinion in Pharmacology. 7: 179-85. PMID 17307396 DOI: 10.1016/J.COPH.2006.10.008 |
0.455 |
|
| 2007 |
Lopaschuk GD. Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure. Seminars in Cardiothoracic and Vascular Anesthesia. 10: 228-30. PMID 16959756 DOI: 10.1177/1089253206291150 |
0.447 |
|
| 2006 |
Lopaschuk GD, Stanley WC. Malonyl-CoA decarboxylase inhibition as a novel approach to treat ischemic heart disease. Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy. 20: 433-9. PMID 17136490 DOI: 10.1007/s10557-006-0634-0 |
0.545 |
|
| 2006 |
Folmes CD, Lopaschuk GD. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovascular Research. 73: 278-87. PMID 17126822 DOI: 10.1016/J.CARDIORES.2006.10.008 |
0.408 |
|
| 2006 |
Dyck JR, Hopkins TA, Bonnet S, Michelakis ED, Young ME, Watanabe M, Kawase Y, Jishage K, Lopaschuk GD. Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury. Circulation. 114: 1721-8. PMID 17030679 DOI: 10.1161/CIRCULATIONAHA.106.642009 |
0.573 |
|
| 2006 |
Cheng JF, Huang Y, Penuliar R, Nishimoto M, Liu L, Arrhenius T, Yang G, O'leary E, Barbosa M, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM. Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. Journal of Medicinal Chemistry. 49: 4055-8. PMID 16821767 DOI: 10.1021/jm0605029 |
0.4 |
|
| 2006 |
Fragasso G, Montano C, Perseghin G, Palloshi A, Calori G, Lattuada G, Oggionni S, Bassanelli G, Locatelli M, Lopaschuk G, Margonato A. The anti-ischemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition. American Heart Journal. 151. PMID 16781225 DOI: 10.1016/J.Ahj.2006.01.006 |
0.309 |
|
| 2006 |
Folmes CD, Clanachan AS, Lopaschuk GD. Fatty acids attenuate insulin regulation of 5'-AMP-activated protein kinase and insulin cardioprotection after ischemia. Circulation Research. 99: 61-8. PMID 16741157 DOI: 10.1161/01.RES.0000229656.05244.11 |
0.407 |
|
| 2006 |
Dyck JR, Lopaschuk GD. AMPK alterations in cardiac physiology and pathology: enemy or ally? The Journal of Physiology. 574: 95-112. PMID 16690706 DOI: 10.1113/jphysiol.2006.109389 |
0.527 |
|
| 2006 |
Cheng JF, Mak CC, Huang Y, Penuliar R, Nishimoto M, Zhang L, Chen M, Wallace D, Arrhenius T, Chu D, Yang G, Barbosa M, Barr R, Dyck JR, Lopaschuk GD, et al. Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 3484-8. PMID 16644218 DOI: 10.1016/j.bmcl.2006.03.100 |
0.34 |
|
| 2006 |
Cheng JF, Chen M, Wallace D, Tith S, Haramura M, Liu B, Mak CC, Arrhenius T, Reily S, Brown S, Thorn V, Harmon C, Barr R, Dyck JR, Lopaschuk GD, et al. Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors. Journal of Medicinal Chemistry. 49: 1517-25. PMID 16509570 DOI: 10.1021/jm050109n |
0.414 |
|
| 2006 |
Collier CA, Bruce CR, Smith AC, Lopaschuk G, Dyck DJ. Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 291: E182-9. PMID 16478780 DOI: 10.1152/Ajpendo.00272.2005 |
0.466 |
|
| 2006 |
DeGrado TR, Kitapci MT, Wang S, Ying J, Lopaschuk GD. Validation of 18F-fluoro-4-thia-palmitate as a PET probe for myocardial fatty acid oxidation: effects of hypoxia and composition of exogenous fatty acids. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 47: 173-81. PMID 16391202 |
0.407 |
|
| 2006 |
Sambandam N, Morabito D, Wagg C, Finck BN, Kelly DP, Lopaschuk GD. Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia. American Journal of Physiology. Heart and Circulatory Physiology. 290: H87-95. PMID 16155108 DOI: 10.1152/Ajpheart.00285.2005 |
0.459 |
|
| 2005 |
Stanley WC, Morgan EE, Huang H, McElfresh TA, Sterk JP, Okere IC, Chandler MP, Cheng J, Dyck JR, Lopaschuk GD. Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia. American Journal of Physiology. Heart and Circulatory Physiology. 289: H2304-9. PMID 16100246 DOI: 10.1152/Ajpheart.00599.2005 |
0.477 |
|
| 2005 |
Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiological Reviews. 85: 1093-129. PMID 15987803 DOI: 10.1152/physrev.00006.2004 |
0.483 |
|
| 2005 |
King KL, Okere IC, Sharma N, Dyck JR, Reszko AE, McElfresh TA, Kerner J, Chandler MP, Lopaschuk GD, Stanley WC. Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power. American Journal of Physiology. Heart and Circulatory Physiology. 289: H1033-7. PMID 15821035 DOI: 10.1152/Ajpheart.00210.2005 |
0.441 |
|
| 2005 |
Folmes CD, Clanachan AS, Lopaschuk GD. Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis. Current Atherosclerosis Reports. 7: 63-70. PMID 15683605 DOI: 10.1007/S11883-005-0077-2 |
0.577 |
|
| 2004 |
Altarejos JY, Taniguchi M, Clanachan AS, Lopaschuk GD. Myocardial ischemia differentially regulates LKB1 and an alternate 5'-AMP-activated protein kinase kinase. The Journal of Biological Chemistry. 280: 183-90. PMID 15507450 DOI: 10.1074/JBC.M411810200 |
0.365 |
|
| 2004 |
Leon H, Atkinson LL, Sawicka J, Strynadka K, Lopaschuk GD, Schulz R. Pyruvate prevents cardiac dysfunction and AMP-activated protein kinase activation by hydrogen peroxide in isolated rat hearts. Canadian Journal of Physiology and Pharmacology. 82: 409-16. PMID 15381965 DOI: 10.1139/y04-050 |
0.389 |
|
| 2004 |
Onay-Besikci A, Altarejos JY, Lopaschuk GD. gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts. The Journal of Biological Chemistry. 279: 44320-6. PMID 15269215 DOI: 10.1074/jbc.M400347200 |
0.769 |
|
| 2004 |
Dyck JR, Cheng JF, Stanley WC, Barr R, Chandler MP, Brown S, Wallace D, Arrhenius T, Harmon C, Yang G, Nadzan AM, Lopaschuk GD. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circulation Research. 94: e78-84. PMID 15105298 DOI: 10.1161/01.Res.0000129255.19569.8F |
0.596 |
|
| 2004 |
Lopaschuk GD. Targets for modulation of fatty acid oxidation in the heart. Current Opinion in Investigational Drugs (London, England : 2000). 5: 290-4. PMID 15083595 |
0.536 |
|
| 2004 |
Kuang M, Febbraio M, Wagg C, Lopaschuk GD, Dyck JR. Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia. Circulation. 109: 1550-7. PMID 15023869 DOI: 10.1161/01.CIR.0000121730.41801.12 |
0.381 |
|
| 2004 |
Fragasso G, Piatti Md PM, Monti L, Palloshi A, Setola E, Puccetti P, Calori G, Lopaschuk GD, Margonato A. Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy. American Heart Journal. 146: E18. PMID 14597947 DOI: 10.1016/S0002-8703(03)00415-0 |
0.323 |
|
| 2003 |
Stanley WC, Meadows SR, Kivilo KM, Roth BA, Lopaschuk GD. beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content. American Journal of Physiology. Heart and Circulatory Physiology. 285: H1626-31. PMID 12969881 DOI: 10.1152/ajpheart.00332.2003 |
0.37 |
|
| 2003 |
Lopaschuk GD, Barr R, Thomas PD, Dyck JR. Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase. Circulation Research. 93: e33-7. PMID 12869392 DOI: 10.1161/01.RES.0000086964.07404.A5 |
0.496 |
|
| 2003 |
Sambandam N, Lopaschuk GD. AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart. Progress in Lipid Research. 42: 238-56. PMID 12689619 DOI: 10.1016/S0163-7827(02)00065-6 |
0.538 |
|
| 2003 |
Hopkins TA, Sugden MC, Holness MJ, Kozak R, Dyck JR, Lopaschuk GD. Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice. American Journal of Physiology. Heart and Circulatory Physiology. 285: H270-6. PMID 12663261 DOI: 10.1152/ajpheart.00852.2002 |
0.375 |
|
| 2003 |
Hopkins TA, Dyck JR, Lopaschuk GD. AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart. Biochemical Society Transactions. 31: 207-12. PMID 12546686 DOI: 10.1042/bst0310207 |
0.535 |
|
| 2003 |
Dyck JR, Lopaschuk GD. Malonyl CoA control of fatty acid oxidation in the ischemic heart. Journal of Molecular and Cellular Cardiology. 34: 1099-109. PMID 12392882 DOI: 10.1006/jmcc.2002.2060 |
0.539 |
|
| 2003 |
Onay-Besikci A, Campbell FM, Hopkins TA, Dyck JR, Lopaschuk GD, Onay Besikci A. Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart. American Journal of Physiology. Heart and Circulatory Physiology. 284: H283-9. PMID 12388233 DOI: 10.1152/ajpheart.00461.2002 |
0.75 |
|
| 2002 |
Osorio JC, Stanley WC, Linke A, Castellari M, Diep QN, Panchal AR, Hintze TH, Lopaschuk GD, Recchia FA. Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure. Circulation. 106: 606-12. PMID 12147544 DOI: 10.1161/01.CIR.0000023531.22727.C1 |
0.338 |
|
| 2002 |
Atkinson LL, Fischer MA, Lopaschuk GD. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. The Journal of Biological Chemistry. 277: 29424-30. PMID 12058043 DOI: 10.1074/jbc.M203813200 |
0.57 |
|
| 2002 |
Sambandam N, Lopaschuk GD, Brownsey RW, Allard MF. Energy metabolism in the hypertrophied heart. Heart Failure Reviews. 7: 161-73. PMID 11988640 DOI: 10.1023/A:1015380609464 |
0.609 |
|
| 2002 |
Lopaschuk GD. Metabolic abnormalities in the diabetic heart. Heart Failure Reviews. 7: 149-59. PMID 11988639 DOI: 10.1023/A:1015328625394 |
0.396 |
|
| 2002 |
Leong HS, Grist M, Parsons H, Wambolt RB, Lopaschuk GD, Brownsey R, Allard MF. Accelerated rates of glycolysis in the hypertrophied heart: are they a methodological artifact? American Journal of Physiology. Endocrinology and Metabolism. 282: E1039-45. PMID 11934668 DOI: 10.1152/Ajpendo.00507.2001 |
0.431 |
|
| 2002 |
Lopaschuk GD. Malonyl CoA control of fatty acid oxidation in the diabetic rat heart. Advances in Experimental Medicine and Biology. 498: 155-65. PMID 11900364 DOI: 10.1007/978-1-4615-1321-6_21 |
0.483 |
|
| 2002 |
Liu Q, Docherty JC, Rendell JC, Clanachan AS, Lopaschuk GD. High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. Journal of the American College of Cardiology. 39: 718-25. PMID 11849874 DOI: 10.1016/S0735-1097(01)01803-4 |
0.784 |
|
| 2002 |
Lopaschuk GD, Rebeyka IM, Allard MF. Metabolic modulation: a means to mend a broken heart. Circulation. 105: 140-2. PMID 11790689 |
0.342 |
|
| 2002 |
Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, Han X, Gross RW, Kozak R, Lopaschuk GD, Kelly DP. The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. The Journal of Clinical Investigation. 109: 121-30. PMID 11781357 DOI: 10.1172/Jci14080 |
0.494 |
|
| 2002 |
Recchia FA, Osorio JC, Chandler MP, Xu X, Panchal AR, Lopaschuk GD, Hintze TH, Stanley WC. Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs. American Journal of Physiology. Endocrinology and Metabolism. 282: E197-206. PMID 11739101 DOI: 10.1152/Ajpendo.2002.282.1.E197 |
0.431 |
|
| 2002 |
Campbell FM, Kozak R, Wagner A, Altarejos JY, Dyck JR, Belke DD, Severson DL, Kelly DP, Lopaschuk GD. A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. The Journal of Biological Chemistry. 277: 4098-103. PMID 11734553 DOI: 10.1074/jbc.M106054200 |
0.562 |
|
| 2001 |
Longnus SL, Wambolt RB, Barr RL, Lopaschuk GD, Allard MF. Regulation of myocardial fatty acid oxidation by substrate supply. American Journal of Physiology. Heart and Circulatory Physiology. 281: H1561-7. PMID 11557544 DOI: 10.1152/AJPHEART.2001.281.4.H1561 |
0.431 |
|
| 2001 |
Taniguchi M, Wilson C, Hunter CA, Pehowich DJ, Clanachan AS, Lopaschuk GD. Dichloroacetate improves cardiac efficiency after ischemia independent of changes in mitochondrial proton leak. American Journal of Physiology. Heart and Circulatory Physiology. 280: H1762-9. PMID 11247790 DOI: 10.1152/AJPHEART.2001.280.4.H1762 |
0.445 |
|
| 2001 |
Custalow CB, Watts JA, Thornton L, O'Malley P, Barbee RW, Grattan RM, Lopaschuk GD, Kline JA. Role of fatty acids in the recovery of cardiac function during resuscitation from hemorrhagic shock Shock. 15: 231-238. PMID 11236908 DOI: 10.1097/00024382-200115030-00012 |
0.518 |
|
| 2001 |
Barr RL, Lopaschuk GD. Methodology for measuring in vitro/ex vivo cardiac energy metabolism. Journal of Pharmacological and Toxicological Methods. 43: 141-52. PMID 11150742 DOI: 10.1016/S1056-8719(00)00096-4 |
0.381 |
|
| 2001 |
Ford WR, Jugdutt BI, Lopaschuk GD, Schulz R, Clanachan AS. Influence of beta-adrenoceptor tone on the cardioprotective efficacy of adenosine A(1) receptor activation in isolated working rat hearts. British Journal of Pharmacology. 131: 537-45. PMID 11015305 DOI: 10.1038/sj.bjp.0703597 |
0.421 |
|
| 2001 |
Lopaschuk GD. Alterations in malonyl CoA control of fatty acid oxidation in the ischemic heart Biochemical Society Transactions. 29: A2-A2. DOI: 10.1042/BST029A002 |
0.487 |
|
| 2001 |
Salki Y, Panas DL, Lopaschuk GD, Rebeyka IM. Effect of pyruvate in cold cardioplegia on cardiac performance after prolonged ischemia in immature rabbit heart Journal of Molecular and Cellular Cardiology. 33: A177. DOI: 10.1016/S0022-2828(01)90681-9 |
0.404 |
|
| 2001 |
Hopkins TA, Dyck JR, Lopaschuk GD. Developmental changes of cardiac glucose metabolism, and pyruvate dehydrogenase activity Journal of Molecular and Cellular Cardiology. 33: A169. DOI: 10.1016/S0022-2828(01)90647-9 |
0.386 |
|
| 2001 |
Campbell FM, Kozak R, Wagner A, Altarelos JY, Dyck JR, Belke DD, Severson DL, Weinheimer CJ, Courtois MR, Kelly DP, Lopaschuk GD. PPARα regulates cardiac energy metabolism by controlling malonyl COA concentrations in the heart Journal of Molecular and Cellular Cardiology. 33: A164. DOI: 10.1016/S0022-2828(01)90627-3 |
0.386 |
|
| 2001 |
Lopaschuk GD. Improvement of energy metabolism in the ischemic heart Journal of Molecular and Cellular Cardiology. 33: A154. DOI: 10.1016/S0022-2828(01)90594-2 |
0.368 |
|
| 2001 |
Dyck JR, Lopaschuk GD. How important is malonyl-CoA decarboxylase as a regulator of fatty acid oxidation in the heart? Journal of Molecular and Cellular Cardiology. 33: A150. DOI: 10.1016/S0022-2828(01)90576-0 |
0.483 |
|
| 2000 |
Wambolt RB, Lopaschuk GD, Brownsey RW, Allard MF. Dichloroacetate improves postischemic function of hypertrophied rat hearts. Journal of the American College of Cardiology. 36: 1378-85. PMID 11028498 DOI: 10.1016/S0735-1097(00)00856-1 |
0.495 |
|
| 2000 |
Kline JA, Thornton LR, Lopaschuk GD, Barbee RW, Watts JA. Lactate improves cardiac efficiency after hemorrhagic shock Shock. 14: 215-221. PMID 10947169 DOI: 10.1097/00024382-200014020-00023 |
0.495 |
|
| 2000 |
Sakamoto J, Barr RL, Kavanagh KM, Lopaschuk GD. Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart. American Journal of Physiology. Heart and Circulatory Physiology. 278: H1196-204. PMID 10749714 DOI: 10.1152/AJPHEART.2000.278.4.H1196 |
0.477 |
|
| 2000 |
Kantor PF, Lucien A, Kozak R, Lopaschuk GD. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circulation Research. 86: 580-8. PMID 10720420 DOI: 10.1161/01.RES.86.5.580 |
0.529 |
|
| 2000 |
Lopaschuk G. Regulation of carbohydrate metabolism in ischemia and reperfusion. American Heart Journal. 139: S115-9. PMID 10650324 DOI: 10.1067/Mhj.2000.103919 |
0.59 |
|
| 1999 |
Kline JA, Thornton LR, Lopaschuk GD, Barbee RW, Watts JA. Heart function after severe hemorrhagic shock Shock. 12: 454-461. PMID 10588514 DOI: 10.1097/00024382-199912000-00007 |
0.376 |
|
| 1999 |
Belke DD, Larsen TS, Lopaschuk GD, Severson DL. Glucose and fatty acid metabolism in the isolated working mouse heart. The American Journal of Physiology. 277: R1210-7. PMID 10516264 DOI: 10.1152/ajpregu.1999.277.4.R1210 |
0.582 |
|
| 1999 |
Fraser H, Lopaschuk GD, Clanachan AS. Alteration of glycogen and glucose metabolism in ischaemic and post-ischaemic working rat hearts by adenosine A1 receptor stimulation. British Journal of Pharmacology. 128: 197-205. PMID 10498852 DOI: 10.1038/sj.bjp.0702765 |
0.455 |
|
| 1999 |
Larsen TS, Belke DD, Sas R, Giles WR, Severson DL, Lopaschuk GD, Tyberg JV. The isolated working mouse heart: Methodological considerations Pflugers Archiv European Journal of Physiology. 437: 979-985. PMID 10370078 DOI: 10.1007/S004240050870 |
0.355 |
|
| 1999 |
Kantor PF, Robertson MA, Coe JY, Lopaschuk GD. Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation of fatty acid metabolism Journal of the American College of Cardiology. 33: 1724-1734. PMID 10334449 DOI: 10.1016/S0735-1097(99)00063-7 |
0.475 |
|
| 1999 |
Dyck JR, Kudo N, Barr AJ, Davies SP, Hardie DG, Lopaschuk GD. Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinase. European Journal of Biochemistry. 262: 184-90. PMID 10231380 DOI: 10.1046/j.1432-1327.1999.00371.x |
0.341 |
|
| 1999 |
Wambolt RB, Henning SL, English DR, Dyachkova Y, Lopaschuk GD, Allard MF. Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia. Journal of Molecular and Cellular Cardiology. 31: 493-502. PMID 10198181 DOI: 10.1006/JMCC.1998.0804 |
0.482 |
|
| 1999 |
Kantor PF, Dyck JR, Lopaschuk GD. Fatty Acid Oxidation in the Reperfused Ischemic Heart The American Journal of the Medical Sciences. 318: 3-14. DOI: 10.1016/S0002-9629(15)40566-X |
0.508 |
|
| 1998 |
Fraser H, Lopaschuk GD, Clanachan AS. Assessment of glycogen turnover in aerobic, ischemic, and reperfused working rat hearts. American Journal of Physiology. Heart and Circulatory Physiology. 275: H1533-H1541. PMID 29592216 DOI: 10.1152/ajpheart.1998.275.5.H1533 |
0.311 |
|
| 1998 |
Dyck JRB, Barr AJ, Barr RL, Kolattukudy PE, Lopaschuk GD. Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation. American Journal of Physiology. Heart and Circulatory Physiology. 275: H2122-H2129. PMID 29586793 DOI: 10.1152/ajpheart.1998.275.6.H2122 |
0.512 |
|
| 1998 |
Liu Q, Clanachan AS, Lopaschuk GD. Acute effects of triiodothyronine on glucose and fatty acid metabolism during reperfusion of ischemic rat hearts. American Journal of Physiology. Endocrinology and Metabolism. 275: E392-E399. PMID 29585551 DOI: 10.1152/ajpendo.1998.275.3.E392 |
0.802 |
|
| 1998 |
Makinde AO, Kantor PF, Lopaschuk GD. Maturation of fatty acid and carbohydrate metabolism in the newborn heart Molecular and Cellular Biochemistry. 188: 49-56. PMID 9823010 DOI: 10.1023/A:1006860104840 |
0.508 |
|
| 1998 |
Saiki Y, Lopaschuk GD, Dodge K, Yamaya K, Morgan C, Rebeyka IM. Pyruvate augments mechanical function via activation of the pyruvate dehydrogenase complex in reperfused ischemic immature rabbit hearts. The Journal of Surgical Research. 79: 164-9. PMID 9758733 DOI: 10.1006/JSRE.1998.5397 |
0.504 |
|
| 1998 |
Lopaschuk GD. Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism. The American Journal of Cardiology. 82: 14K-17K. PMID 9737481 DOI: 10.1016/S0002-9149(98)00532-3 |
0.531 |
|
| 1998 |
Liu Q, Clanachan AS, Lopaschuk GD. Acute effects of triiodothyronine on glucose and fatty acid metabolism during reperfusion of ischemic rat hearts. The American Journal of Physiology. 275: E392-9. PMID 9725804 DOI: 10.1152/Ajpendo.1998.275.3.E392 |
0.799 |
|
| 1998 |
Ford WR, Lopaschuk GD, Schulz R, Clanachan AS. K(ATP)-channel activation: effects on myocardial recovery from ischaemia and role in the cardioprotective response to adenosine A1-receptor stimulation. British Journal of Pharmacology. 124: 639-46. PMID 9690854 DOI: 10.1038/sj.bjp.0701872 |
0.431 |
|
| 1998 |
Belke DD, Wang LC, Lopaschuk GD. Acetyl-CoA carboxylase control of fatty acid oxidation in hearts from hibernating Richardson's ground squirrels. Biochimica Et Biophysica Acta. 1391: 25-36. PMID 9518540 DOI: 10.1016/S0005-2760(97)00199-9 |
0.553 |
|
| 1997 |
Gamble J, Lopaschuk GD. Insulin inhibition of 5' adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation. Metabolism: Clinical and Experimental. 46: 1270-4. PMID 9361684 DOI: 10.1016/S0026-0495(97)90229-8 |
0.477 |
|
| 1997 |
Barr RL, Lopaschuk GD. Direct measurement of energy metabolism in the isolated working rat heart. Journal of Pharmacological and Toxicological Methods. 38: 11-7. PMID 9339411 DOI: 10.1016/S1056-8719(97)86574-4 |
0.5 |
|
| 1997 |
Schönekess BO, Allard MF, Henning SL, Wambolt RB, Lopaschuk GD. Contribution of glycogen and exogenous glucose to glucose metabolism during ischemia in the hypertrophied rat heart. Circulation Research. 81: 540-9. PMID 9314835 DOI: 10.1161/01.RES.81.4.540 |
0.465 |
|
| 1997 |
Lopaschuk GD. Alterations in fatty acid oxidation during reperfusion of the heart after myocardial ischemia. The American Journal of Cardiology. 80: 11A-16A. PMID 9293951 DOI: 10.1016/S0002-9149(97)00453-0 |
0.55 |
|
| 1997 |
Lopaschuk GD. Advantages and limitations of experimental techniques used to measure cardiac energy metabolism. Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology. 4: 316-28. PMID 9278879 DOI: 10.1016/S1071-3581(97)90110-0 |
0.39 |
|
| 1997 |
Allard MF, Henning SL, Wambolt RB, Granleese SR, English DR, Lopaschuk GD. Glycogen metabolism in the aerobic hypertrophied rat heart. Circulation. 96: 676-82. PMID 9244242 DOI: 10.1161/01.CIR.96.2.676 |
0.469 |
|
| 1997 |
Feuvray D, Lopaschuk GD. Controversies on the sensitivity of the diabetic heart to ischemic injury: the sensitivity of the diabetic heart to ischemic injury is decreased. Cardiovascular Research. 34: 113-20. PMID 9217880 DOI: 10.1016/S0008-6363(97)00037-0 |
0.308 |
|
| 1997 |
Stanley WC, Lopaschuk GD, McCormack JG. Regulation of energy substrate metabolism in the diabetic heart. Cardiovascular Research. 34: 25-33. PMID 9217869 DOI: 10.1016/S0008-6363(97)00047-3 |
0.495 |
|
| 1997 |
Makinde AO, Gamble J, Lopaschuk GD. Upregulation of 5'-AMP-activated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit. Circulation Research. 80: 482-9. PMID 9118478 DOI: 10.1161/01.RES.80.4.482 |
0.48 |
|
| 1997 |
Belke DD, Wang LC, Lopaschuk GD. Effects of hypothermia on energy metabolism in rat and Richardson's ground squirrel hearts. Journal of Applied Physiology (Bethesda, Md. : 1985). 82: 1210-8. PMID 9104858 DOI: 10.1152/JAPPL.1997.82.4.1210 |
0.444 |
|
| 1997 |
Schulz R, Dodge KL, Lopaschuk GD, Clanachan AS. Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency. The American Journal of Physiology. 272: H1212-9. PMID 9087595 DOI: 10.1152/AJPHEART.1997.272.3.H1212 |
0.423 |
|
| 1997 |
Stanley WC, Lopaschuk GD, Hall JL, McCormack JG. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovascular Research. 33: 243-57. PMID 9074687 DOI: 10.1016/S0008-6363(96)00245-3 |
0.512 |
|
| 1997 |
Lopaschuk GD, Stanley WC. Glucose metabolism in the ischemic heart. Circulation. 95: 313-5. PMID 9008441 DOI: 10.1161/01.CIR.95.2.313 |
0.441 |
|
| 1997 |
McCormack JG, Baracos VE, Barr R, Lopaschuk GD. Effects of ranolazine on oxidative substrate preference in epitrochlearis muscle. Journal of Applied Physiology (Bethesda, Md. : 1985). 81: 905-10. PMID 8872662 DOI: 10.1152/JAPPL.1996.81.2.905 |
0.404 |
|
| 1997 |
Schönekess BO, Brindley PG, Lopaschuk GD. Calcium regulation of glycolysis, glucose oxidation, and fatty acid oxidation in the aerobic and ischemic heart. Canadian Journal of Physiology and Pharmacology. 73: 1632-40. PMID 8789418 DOI: 10.1139/Y95-725 |
0.477 |
|
| 1996 |
Hall JL, Stanley WC, Lopaschuk GD, Wisneski JA, Pizzurro RD, Hamilton CD, McCormack JG. Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work. The American Journal of Physiology. 271: H2320-9. PMID 8997289 DOI: 10.1152/AJPHEART.1996.271.6.H2320 |
0.353 |
|
| 1996 |
Hall JL, Lopaschuk GD, Barr A, Bringas J, Pizzurro RD, Stanley WC. Increased cardiac fatty acid uptake with dobutamine infusion in swine is accompanied by a decrease in malonyl CoA levels. Cardiovascular Research. 32: 879-85. PMID 8944819 DOI: 10.1016/0008-6363(96)00153-8 |
0.486 |
|
| 1996 |
Sidossis LS, Stuart CA, Shulman GI, Lopaschuk GD, Wolfe RR. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. The Journal of Clinical Investigation. 98: 2244-50. PMID 8941640 DOI: 10.1172/Jci119034 |
0.391 |
|
| 1996 |
Liu B, Clanachan AS, Schulz R, Lopaschuk GD. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circulation Research. 79: 940-8. PMID 8888686 DOI: 10.1161/01.RES.79.5.940 |
0.467 |
|
| 1996 |
Olley PM, Kasserra J, Kozak R, Lopaschuk GD. Synergism between prostaglandin E2 and isoproterenol in stimulating glucose oxidation in the heart. Canadian Journal of Physiology and Pharmacology. 74: 590-7. PMID 8884025 DOI: 10.1139/CJPP-74-5-586 |
0.459 |
|
| 1996 |
Itoi T, Lopaschuk GD. Calcium improves mechanical function and carbohydrate metabolism following ischemia in isolated Bi-ventricular working hearts from immature rabbits. Journal of Molecular and Cellular Cardiology. 28: 1501-14. PMID 8841937 DOI: 10.1006/JMCC.1996.0140 |
0.331 |
|
| 1996 |
Allard MF, Lopaschuk GD. Ischemia and reperfusion injury in the hypertrophied heart Exs. 76: 423-441. PMID 8805809 DOI: 10.1007/978-3-0348-8988-9_25 |
0.302 |
|
| 1996 |
Schönekess BO, Allard MF, Lopaschuk GD. Recovery of glycolysis and oxidative metabolism during postischemic reperfusion of hypertrophied rat hearts. The American Journal of Physiology. 271: H798-805. PMID 8770125 DOI: 10.1152/AJPHEART.1996.271.2.H798 |
0.526 |
|
| 1996 |
Liu B, el Alaoui-Talibi Z, Clanachan AS, Schulz R, Lopaschuk GD. Uncoupling of contractile function from mitochondrial TCA cycle activity and MVO2 during reperfusion of ischemic hearts. The American Journal of Physiology. 270: H72-80. PMID 8769736 DOI: 10.1152/AJPHEART.1996.270.1.H72 |
0.509 |
|
| 1996 |
Finegan BA, Lopaschuk GD, Gandhi M, Clanachan AS. Inhibition of glycolysis and enhanced mechanical function of working rat hearts as a result of adenosine A1 receptor stimulation during reperfusion following ischaemia. British Journal of Pharmacology. 118: 355-63. PMID 8735638 DOI: 10.1111/j.1476-5381.1996.tb15410.x |
0.386 |
|
| 1996 |
Kudo N, Gillespie JG, Kung L, Witters LA, Schulz R, Clanachan AS, Lopaschuk GD. Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia. Biochimica Et Biophysica Acta. 1301: 67-75. PMID 8652652 DOI: 10.1016/0005-2760(96)00013-6 |
0.4 |
|
| 1996 |
McCormack JG, Barr RL, Wolff AA, Lopaschuk GD. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation. 93: 135-42. PMID 8616920 DOI: 10.1161/01.CIR.93.1.135 |
0.552 |
|
| 1996 |
Henning SL, Wambolt RB, Schönekess BO, Lopaschuk GD, Allard MF. Contribution of glycogen to aerobic myocardial glucose utilization. Circulation. 93: 1549-55. PMID 8608624 DOI: 10.1161/01.CIR.93.8.1549 |
0.415 |
|
| 1996 |
Schönekess BO, Allard MF, Lopaschuk GD. Propionyl L-carnitine improvement of hypertrophied rat heart function is associated with an increase in cardiac efficiency. European Journal of Pharmacology. 286: 155-66. PMID 8605952 DOI: 10.1016/0014-2999(95)00442-N |
0.513 |
|
| 1996 |
Finegan BA, Lopaschuk GD, Gandhi M, Clanachan AS. Ischemic preconditioning inhibits glycolysis and proton production in isolated working rat hearts. The American Journal of Physiology. 269: H1767-75. PMID 7503276 DOI: 10.1152/AJPHEART.1995.269.5.H1767 |
0.458 |
|
| 1996 |
Olley PM, Kasserra J, Kozak R, Lopaschuk GD. Synergism between prostaglandin E2 and isoproterenol in stimulating glucose oxidation in the heart Canadian Journal of Physiology and Pharmacology. 74: 586-589. DOI: 10.1139/y96-053 |
0.414 |
|
| 1996 |
Hall JL, Lopaschuk GD, Barr A, Bringas J, Pizzurro RD, Stanley WC. Increased cardiac fatty acid uptake with dobutamine infusion in swine is accompanied by a decrease in malonyl CoA levels Cardiovascular Research. 32: 879-885. DOI: 10.1016/s0008-6363(96)00153-8 |
0.398 |
|
| 1995 |
Saddik M, Lopaschuk GD. Triacylglycerol turnover in isolated working hearts of acutely diabetic rats. Canadian Journal of Physiology and Pharmacology. 72: 1110-9. PMID 7882174 DOI: 10.1139/Y94-157 |
0.483 |
|
| 1995 |
Lopaschuk GD, Gamble J. The 1993 Merck Frosst Award. Acetyl-CoA carboxylase: an important regulator of fatty acid oxidation in the heart. Canadian Journal of Physiology and Pharmacology. 72: 1101-9. PMID 7882173 DOI: 10.1139/Y94-156 |
0.507 |
|
| 1995 |
Kudo N, Barr AJ, Barr RL, Desai S, Lopaschuk GD. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. The Journal of Biological Chemistry. 270: 17513-20. PMID 7615556 DOI: 10.1074/JBC.270.29.17513 |
0.484 |
|
| 1995 |
Schönekess BO, Allard MF, Lopaschuk GD. Propionyl L-carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation. Circulation Research. 77: 726-34. PMID 7554119 DOI: 10.1161/01.RES.77.4.726 |
0.501 |
|
| 1995 |
Broderick TL, Quinney HA, Lopaschuk GD. L-carnitine increases glucose metabolism and mechanical function following ischaemia in diabetic rat heart Cardiovascular Research. 29: 373-378. DOI: 10.1016/S0008-6363(96)88594-4 |
0.348 |
|
| 1995 |
Broderick TL, Panagakis G, DiDomenico D, Gamble J, Lopaschuk GD, Shug AL, Paulson DJ. L-Carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts Cardiovascular Research. 30: 815-820. DOI: 10.1016/S0008-6363(95)00111-5 |
0.491 |
|
| 1994 |
Gamble J, Lopaschuk GD. Glycolysis and glucose oxidation during reperfusion of ischemic hearts from diabetic rats. Biochimica Et Biophysica Acta. 1225: 191-9. PMID 8280788 DOI: 10.1016/0925-4439(94)90078-7 |
0.428 |
|
| 1994 |
Lopaschuk GD, Lakey JR, Barr R, Wambolt R, Thomson AB, Clandinin MT, Rajotte RV. Islet transplantation improves glucose oxidation and mechanical function in diabetic rat hearts. Canadian Journal of Physiology and Pharmacology. 71: 896-903. PMID 8180885 DOI: 10.1139/Y93-136 |
0.359 |
|
| 1994 |
Itoi T, Lopaschuk GD. The contribution of glycolysis, glucose oxidation, lactate oxidation, and fatty acid oxidation to ATP production in isolated biventricular working hearts from 2-week-old rabbits. Pediatric Research. 34: 735-41. PMID 8108185 DOI: 10.1203/00006450-199312000-00008 |
0.531 |
|
| 1994 |
Allard MF, Schönekess BO, Henning SL, English DR, Lopaschuk GD. Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts. The American Journal of Physiology. 267: H742-50. PMID 8067430 DOI: 10.1152/AJPHEART.1994.267.2.H742 |
0.518 |
|
| 1994 |
Lopaschuk GD, Belke DD, Gamble J, Itoi T, Schönekess BO. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochimica Et Biophysica Acta. 1213: 263-76. PMID 8049240 DOI: 10.1016/0005-2760(94)00082-4 |
0.407 |
|
| 1994 |
Lopaschuk GD, Collins-Nakai R, Olley PM, Montague TJ, McNeil G, Gayle M, Penkoske P, Finegan BA. Plasma fatty acid levels in infants and adults after myocardial ischemia. American Heart Journal. 128: 61-7. PMID 8017285 DOI: 10.1016/0002-8703(94)90010-8 |
0.372 |
|
| 1994 |
Collins-Nakai RL, Noseworthy D, Lopaschuk GD. Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism. The American Journal of Physiology. 267: H1862-71. PMID 7977816 DOI: 10.1152/AJPHEART.1994.267.5.H1862 |
0.543 |
|
| 1994 |
Lopaschuk GD, Witters LA, Itoi T, Barr R, Barr A. Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart. Journal of Biological Chemistry. 269: 25871-25878. DOI: 10.1016/s0021-9258(18)47327-9 |
0.488 |
|
| 1993 |
Broderick TL, Quinney HA, Barker CC, Lopaschuk GD. Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. Circulation. 87: 972-81. PMID 8443916 DOI: 10.1161/01.CIR.87.3.972 |
0.563 |
|
| 1993 |
Finegan BA, Lopaschuk GD, Coulson CS, Clanachan AS. Adenosine alters glucose use during ischemia and reperfusion in isolated rat hearts. Circulation. 87: 900-8. PMID 8443910 DOI: 10.1161/01.CIR.87.3.900 |
0.43 |
|
| 1993 |
Itoi T, Huang L, Lopaschuk GD. Glucose use in neonatal rabbit hearts reperfused after global ischemia. The American Journal of Physiology. 265: H427-33. PMID 8368344 DOI: 10.1152/AJPHEART.1993.265.2.H427 |
0.504 |
|
| 1993 |
Schulz R, Strynadka KD, Panas DL, Olley PM, Lopaschuk GD. Analysis of myocardial plasmalogen and diacyl phospholipids and their arachidonic acid content using high-performance liquid chromatography. Analytical Biochemistry. 213: 140-6. PMID 8238866 DOI: 10.1006/ABIO.1993.1397 |
0.324 |
|
| 1993 |
Lopaschuk GD, Spafford MA. Differences in myocardial ischemic tolerance between 1- and 7-day-old rabbits. Canadian Journal of Physiology and Pharmacology. 70: 1315-23. PMID 1490250 DOI: 10.1139/Y92-184 |
0.471 |
|
| 1993 |
Lopaschuk GD, Saddik M. The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia. Molecular and Cellular Biochemistry. 116: 111-6. PMID 1480139 DOI: 10.1007/BF01270577 |
0.591 |
|
| 1993 |
Lopaschuk GD, Saddik M, Barr R, Huang L, Barker CC, Muzyka RA. Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats. The American Journal of Physiology. 263: E1046-53. PMID 1476176 DOI: 10.1152/ajpendo.2006.263.6.E1046 |
0.372 |
|
| 1993 |
Lopaschuk GD, Collins-Nakai RL, Itoi T. Developmental changes in energy substrate use by the heart. Cardiovascular Research. 26: 1172-80. PMID 1288863 DOI: 10.1093/CVR/26.12.1172 |
0.434 |
|
| 1992 |
Davies NJ, McVeigh JJ, Lopaschuk GD. Effects of TA-3090, a new calcium channel blocker, on myocardial substrate utilization in ischemic and nonischemic isolated working fatty acid-perfused rat hearts. Circulation Research. 68: 807-17. PMID 1742868 DOI: 10.1161/01.RES.68.3.807 |
0.468 |
|
| 1992 |
Davies NJ, Lovlin RE, Lopaschuk GD. Effect of exogenous fatty acids on reperfusion arrhythmias in isolated working perfused hearts. The American Journal of Physiology. 262: H1796-801. PMID 1621838 DOI: 10.1152/AJPHEART.1992.262.6.H1796 |
0.495 |
|
| 1992 |
Finegan BA, Clanachan AS, Coulson CS, Lopaschuk GD. Adenosine modification of energy substrate use in isolated hearts perfused with fatty acids. The American Journal of Physiology. 262: H1501-7. PMID 1590454 DOI: 10.1152/AJPHEART.1992.262.5.H1501 |
0.513 |
|
| 1992 |
Davies NJ, Schulz R, Olley PM, Strynadka KD, Panas DL, Lopaschuk GD. Lysoplasmenylethanolamine accumulation in ischemic/reperfused isolated fatty acid-perfused hearts. Circulation Research. 70: 1161-8. PMID 1576737 DOI: 10.1161/01.RES.70.6.1161 |
0.494 |
|
| 1992 |
Broderick TL, Barr RL, Quinney HA, Lopaschuk GD. Acute insulin withdrawal from diabetic BB rats decreases myocardial glycolysis during low-flow ischemia. Metabolism: Clinical and Experimental. 41: 332-8. PMID 1542273 DOI: 10.1016/0026-0495(92)90280-N |
0.322 |
|
| 1992 |
Saddik M, Lopaschuk G. Myocardial triglyceride turnover during reperfusion of isolated rat hearts subjected to a transient period of global ischemia. Journal of Biological Chemistry. 267: 3825-3831. DOI: 10.1016/s0021-9258(19)50600-7 |
0.316 |
|
| 1992 |
Broderick T, Quinney H, Lopaschuk G. Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart. Journal of Biological Chemistry. 267: 3758-3763. DOI: 10.1016/s0021-9258(19)50590-7 |
0.488 |
|
| 1991 |
Nicholl TA, Lopaschuk GD, McNeill JH. Effects of free fatty acids and dichloroacetate on isolated working diabetic rat heart. The American Journal of Physiology. 261: H1053-9. PMID 1928388 DOI: 10.1152/AJPHEART.1991.261.4.H1053 |
0.392 |
|
| 1991 |
Lopaschuk GD, Russell JC. Myocardial function and energy substrate metabolism in the insulin-resistant JCR:LA corpulent rat Journal of Applied Physiology. 71: 1302-1308. PMID 1757353 DOI: 10.1152/JAPPL.1991.71.4.1302 |
0.308 |
|
| 1991 |
Lopaschuk GD, Spafford MA, Marsh DR. Glycolysis is predominant source of myocardial ATP production immediately after birth American Journal of Physiology - Heart and Circulatory Physiology. 261. PMID 1750528 DOI: 10.1152/AJPHEART.1991.261.6.H1698 |
0.437 |
|
| 1991 |
Saddik M, Lopaschuk G. Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts Journal of Biological Chemistry. 266: 8162-8170. DOI: 10.1016/s0021-9258(18)92956-x |
0.337 |
|
| 1990 |
Lopaschuk GD, Spafford MA. Energy substrate utilization by isolated working hearts from newborn rabbits. The American Journal of Physiology. 258: H1274-80. PMID 2337162 DOI: 10.1152/AJPHEART.1990.258.5.H1274 |
0.465 |
|
| 1990 |
Lopaschuk GD, Spafford MA, Davies NJ, Wall SR. Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia Circulation Research. 66: 546-553. PMID 2297817 DOI: 10.1161/01.RES.66.2.546 |
0.51 |
|
| 1990 |
McVeigh JJ, Lopaschuk GD. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. The American Journal of Physiology. 259: H1079-85. PMID 2221115 DOI: 10.1152/AJPHEART.1990.259.4.H1079 |
0.55 |
|
| 1990 |
Lopaschuk GD, Spafford MA. Acute insulin withdrawal contributes to ischemic heart failure in spontaneously diabetic BB Wistar rats. Canadian Journal of Physiology and Pharmacology. 68: 462-6. PMID 2182188 DOI: 10.1139/Y90-065 |
0.386 |
|
| 1990 |
LOPASCHUK G. Differential effects of fatty acids on reperfusion recovery of ischemic hearts from control and diabetic rats Journal of Molecular and Cellular Cardiology. 22: S42. DOI: 10.1016/0022-2828(90)91434-9 |
0.344 |
|
| 1989 |
Wall SR, Lopaschuk GD. Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 1006: 97-103. PMID 2804076 DOI: 10.1016/0005-2760(89)90328-7 |
0.49 |
|
| 1989 |
Lopaschuk GD, McNeil GF, McVeigh JJ. Glucose oxidation is stimulated in reperfused ischemic hearts with the carnitine palmitoyltransferase 1 inhibitor, Etomoxir. Molecular and Cellular Biochemistry. 88: 175-9. PMID 2779537 DOI: 10.1007/BF00223440 |
0.502 |
|
| 1989 |
Lopaschuk GD, Spafford M. Response of isolated working hearts to fatty acids and carnitine palmitoyltransferase I inhibition during reduction of coronary flow in acutely and chronically diabetic rats. Circulation Research. 65: 378-87. PMID 2526694 DOI: 10.1161/01.RES.65.2.378 |
0.396 |
|
| 1988 |
Lopaschuk GD, Wall SR, Olley PM, Davies NJ. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine Circulation Research. 63: 1036-1043. PMID 3197271 DOI: 10.1161/01.RES.63.6.1036 |
0.446 |
|
| 1988 |
Lopaschuk GD. Insulin effects on pantothenic acid uptake in isolated perfused working hearts from diabetic rats. Diabetes. 37: 1335-9. PMID 3046966 DOI: 10.2337/diab.37.10.1335 |
0.375 |
|
| 1987 |
Lopaschuk GD, Neely JR. Stimulation of myocardial coenzyme A degradation by fatty acids. The American Journal of Physiology. 253: H41-6. PMID 3605370 DOI: 10.1152/AJPHEART.1987.253.1.H41 |
0.379 |
|
| 1987 |
Lopaschuk GD, Neely JR. Coenzyme A degradation in the heart: effects of diabetes and insulin. Journal of Molecular and Cellular Cardiology. 19: 281-8. PMID 3298661 DOI: 10.1016/S0022-2828(87)80595-3 |
0.362 |
|
| 1987 |
LOPASCHUK G, TSANG H. Fatty acid metabolism in isolated working hearts from spontaneously diabetic “BB”wistar rats* Journal of Molecular and Cellular Cardiology. 19: S54-S54. DOI: 10.1016/S0022-2828(87)80169-4 |
0.353 |
|
| 1987 |
Lopaschuk G, Michalak M, Tsang H. Regulation of pantothenic acid transport in the heart. Involvement of a Na+-cotransport system. Journal of Biological Chemistry. 262: 3615-3619. DOI: 10.1016/s0021-9258(18)61397-3 |
0.301 |
|
| 1986 |
Lopaschuk GD, Hansen CA, Neely JR. Fatty acid metabolism in hearts containing elevated levels of CoA. The American Journal of Physiology. 250: H351-9. PMID 3953832 DOI: 10.1152/AJPHEART.1986.250.3.H351 |
0.437 |
|
| 1984 |
LOPASCHUK G, BERKICH D, NEELY J. Stimulation of myocardial CoA degradation by fatty acids* Journal of Molecular and Cellular Cardiology. 16: 47-47. DOI: 10.1016/S0022-2828(84)80498-8 |
0.314 |
|
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