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David A. Agard - Publications

Affiliations: 
Biochemistry and Biophysics University of California, San Francisco, San Francisco, CA 
Area:
Structure, function, and folding of proteins, chromosomes, and centrosomes
Website:
http://www.msg.ucsf.edu/agard/people/Agard/david.html
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268 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Nieweglowska ES, Brilot AF, Méndez-Moran M, Kokontis C, Baek M, Li J, Cheng Y, Baker D, Bondy-Denomy J, Agard DA. The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice. Nature Communications. 14: 927. PMID 36807264 DOI: 10.1038/s41467-023-36526-9  0.367
2023 Chen Z, Greenan GA, Shiozaki M, Liu Y, Skinner WM, Zhao X, Zhao S, Yan R, Yu Z, Lishko PV, Agard DA, Vale RD. In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes. Nature Structural & Molecular Biology. PMID 36593309 DOI: 10.1038/s41594-022-00861-0  0.407
2022 Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N. Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface. Nature. PMID 35132240 DOI: 10.1038/s41586-021-04299-0  0.782
2022 Wang RY, Noddings CM, Kirschke E, Myasnikov AG, Johnson JL, Agard DA. Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature. 601: 460-464. PMID 34937942 DOI: 10.1038/s41586-021-04252-1  0.787
2022 Noddings CM, Wang RY, Johnson JL, Agard DA. Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism. Nature. 601: 465-469. PMID 34937936 DOI: 10.1038/s41586-021-04236-1  0.577
2021 Croxford M, Elbaum M, Arigovindan M, Kam Z, Agard D, Villa E, Sedat J. Entropy-regularized deconvolution of cellular cryotransmission electron tomograms. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34876518 DOI: 10.1073/pnas.2108738118  0.493
2021 Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N. Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface. Nature. PMID 34759323 DOI: 10.1038/s41586-021-04084-z  0.789
2021 Verba K, Gupta M, Azumaya C, Moritz M, Pourmal S, Diallo A, Merz G, Jang G, Bouhaddou M, Fossati A, Brilot A, Diwanji D, Hernandez E, Herrera N, Kratochvil H, ... ... Agard D, et al. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Research Square. PMID 34031651 DOI: 10.21203/rs.3.rs-515215/v1  0.784
2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, ... ... Agard DA, et al. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Biorxiv : the Preprint Server For Biology. PMID 34013269 DOI: 10.1101/2021.05.10.443524  0.784
2021 Sun M, Azumaya C, Tse E, Frost A, Southworth D, Verba KA, Cheng Y, Agard DA. Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. Journal of Structural Biology. 107745. PMID 33984504 DOI: 10.1016/j.jsb.2021.107745  0.726
2021 Rice LM, Moritz M, Agard DA. Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation. The Journal of Cell Biology. 220. PMID 33734292 DOI: 10.1083/jcb.202012079  0.624
2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, ... ... Agard DA, et al. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.). PMID 33060197 DOI: 10.1126/science.abe9403  0.753
2020 Wang F, Liu Y, Yu Z, Li S, Feng S, Cheng Y, Agard DA. General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM. Proceedings of the National Academy of Sciences of the United States of America. PMID 32913054 DOI: 10.1073/Pnas.2009707117  0.42
2020 Wolff G, Limpens RWAL, Zevenhoven-Dobbe JC, Laugks U, Zheng S, de Jong AWM, Koning RI, Agard DA, Grünewald K, Koster AJ, Snijder EJ, Bárcena M. A molecular pore spans the double membrane of the coronavirus replication organelle. Science (New York, N.Y.). PMID 32763915 DOI: 10.1126/Science.Abd3629  0.303
2020 King BR, Moritz M, Kim H, Agard DA, Asbury CL, Davis TN. XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions. Molecular Biology of the Cell. mbcE20020160. PMID 32726183 DOI: 10.1091/Mbc.E20-02-0160  0.31
2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, ... ... Agard D, et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. Biorxiv : the Preprint Server For Biology. PMID 32511329 DOI: 10.1101/2020.03.22.002386  0.55
2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, ... ... Agard DA, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. PMID 32353859 DOI: 10.1038/S41586-020-2286-9  0.781
2020 Joshi A, Dai L, Liu Y, Lee J, Ghahhari NM, Segala G, Beebe K, Jenkins LM, Lyons GC, Bernasconi L, Tsai FTF, Agard DA, Neckers L, Picard D. The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis. Bmc Biology. 18: 10. PMID 31987035 DOI: 10.1186/S12915-020-0740-7  0.376
2020 Greenan GA, Vale RD, Agard DA. Electron cryotomography of intact motile cilia defines the basal body to axoneme transition. The Journal of Cell Biology. 219. PMID 31874113 DOI: 10.1083/Jcb.201907060  0.361
2019 Wolff G, Limpens RWAL, Zheng S, Snijder EJ, Agard DA, Koster AJ, Bárcena M. Mind the gap: micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae. Journal of Structural Biology. PMID 31536774 DOI: 10.1016/J.Jsb.2019.09.006  0.32
2019 Chaikeeratisak V, Khanna K, Nguyen KT, Sugie J, Egan ME, Erb ML, Vavilina A, Nonejuie P, Nieweglowska E, Pogliano K, Agard DA, Villa E, Pogliano J. Viral Capsid Trafficking along Treadmilling Tubulin Filaments in Bacteria. Cell. 177: 1771-1780.e12. PMID 31199917 DOI: 10.1016/J.Cell.2019.05.032  0.309
2019 Li S, Fernandez JJ, Marshall WF, Agard DA. Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism. Elife. 8. PMID 30741631 DOI: 10.7554/Elife.43434  0.572
2019 Li S, Fernandez J, Marshall WF, Agard DA. Author response: Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism Elife. DOI: 10.7554/Elife.43434.060  0.511
2018 Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE. Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau. Nature Communications. 9: 4563. PMID 30385828 DOI: 10.1038/S41467-018-07012-4  0.33
2018 Greenan GA, Keszthelyi B, Vale RD, Agard DA. Insights into centriole geometry revealed by cryoTomography of doublet and triplet centrioles. Elife. 7. PMID 30080137 DOI: 10.7554/Elife.36851  0.364
2018 Elnatan D, Agard DA. Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. The Journal of Biological Chemistry. PMID 29991590 DOI: 10.1074/Jbc.Ra118.003562  0.303
2018 Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature. PMID 29899447 DOI: 10.1038/S41586-018-0211-2  0.606
2018 Moroni E, Agard DA, Colombo G. The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics. Journal of Chemical Theory and Computation. PMID 29320629 DOI: 10.1021/Acs.Jctc.7B00766  0.383
2018 Citron YR, Fagerstrom CJ, Keszthelyi B, Huang B, Rusan NM, Kelly MJS, Agard DA. The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles. Plos One. 13: e0190530. PMID 29315319 DOI: 10.1371/Journal.Pone.0190530  0.392
2018 Liu Y, Agard DA. Structural Insights into the Regulation Mechanism of HSP90 by Co-chaperone AHA1 Biophysical Journal. 114: 162a. DOI: 10.1016/J.Bpj.2017.11.907  0.455
2017 Verba KA, Agard DA. Protein Expression and Purification of the Hsp90-Cdc37-Cdk4 Kinase Complex from Saccharomyces cerevisiae. Bio-Protocol. 7. PMID 29104897 DOI: 10.21769/BioProtoc.2563  0.739
2017 Verba KA, Agard DA. How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches. Trends in Biochemical Sciences. PMID 28784328 DOI: 10.1016/J.Tibs.2017.07.002  0.74
2017 Elnatan D, Betegon M, Liu Y, Ramelot T, Kennedy MA, Agard DA. Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1. Elife. 6. PMID 28742020 DOI: 10.7554/Elife.25235  0.464
2017 Pederson K, Chalmers GR, Gao Q, Elnatan D, Ramelot TA, Ma LC, Montelione GT, Kennedy MA, Agard DA, Prestegard JH. NMR characterization of HtpG, the E. coli Hsp90, using sparse labeling with (13)C-methyl alanine. Journal of Biomolecular Nmr. PMID 28653216 DOI: 10.1007/S10858-017-0123-8  0.344
2017 Larson AG, Elnatan D, Keenen MM, Trnka MJ, Johnston JB, Burlingame AL, Agard DA, Redding S, Narlikar GJ. Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. Nature. PMID 28636604 DOI: 10.1038/Nature22822  0.32
2017 Zheng SQ, Palovcak E, Armache JP, Verba KA, Cheng Y, Agard DA. MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy. Nature Methods. PMID 28250466 DOI: 10.1038/Nmeth.4193  0.72
2017 Chaikeeratisak V, Nguyen K, Khanna K, Brilot AF, Erb ML, Coker JK, Vavilina A, Newton GL, Buschauer R, Pogliano K, Villa E, Agard DA, Pogliano J. Assembly of a nucleus-like structure during viral replication in bacteria. Science (New York, N.Y.). 355: 194-197. PMID 28082593 DOI: 10.1126/Science.Aal2130  0.358
2017 Elnatan D, Betegon M, Liu Y, Ramelot T, Kennedy MA, Agard DA. Author response: Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1 Elife. DOI: 10.7554/Elife.25235.016  0.38
2017 Verba KA, Agard DA. Kinase Regulation Through Dramatic Unfolding, as Told by Hsp90:Cdc37:Cdk4 Atomic Cryoem Structure Biophysical Journal. 112: 14a. DOI: 10.1016/J.Bpj.2016.11.108  0.313
2016 Duan D, Torosyan H, Elnatan D, McLaughlin CK, Logie J, Shoichet MS, Agard DA, Shoichet BK. Internal Structure and Preferential Protein Binding of Colloidal Aggregates. Acs Chemical Biology. PMID 27983786 DOI: 10.1021/Acschembio.6B00791  0.796
2016 Verba KA, Wang RY, Arakawa A, Liu Y, Shirouzu M, Yokoyama S, Agard DA. Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase. Science (New York, N.Y.). 352: 1542-7. PMID 27339980 DOI: 10.1126/Science.Aaf5023  0.787
2016 Lyon AS, Morin G, Moritz M, Yabut KC, Vojnar T, Zelter A, Muller E, Davis TN, Agard DA. Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly. Molecular Biology of the Cell. 27: 2245-58. PMID 27226487 DOI: 10.1091/Mbc.E16-02-0072  0.331
2016 Vettoretti G, Moroni E, Sattin S, Tao J, Agard DA, Bernardi A, Colombo G. Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands. Scientific Reports. 6: 23830. PMID 27032695 DOI: 10.1038/Srep23830  0.346
2016 Greenberg CH, Kollman J, Zelter A, Johnson R, MacCoss MJ, Davis TN, Agard DA, Sali A. Structure of γ-tubulin small complex based on a cryo-EM map, chemical cross-links, and a remotely related structure. Journal of Structural Biology. PMID 26968363 DOI: 10.1016/J.Jsb.2016.03.006  0.669
2016 Sattin S, Panza M, Vasile F, Berni F, Goti G, Tao J, Moroni E, Agard D, Colombo G, Bernardi A. Synthesis of Functionalized 2-(4-Hydroxyphenyl)-3-methylbenzofuran Allosteric Modulators of Hsp90 Activity European Journal of Organic Chemistry. 2016: 3349-3364. DOI: 10.1002/Ejoc.201600420  0.356
2015 Pimentel-Elardo SM, Sørensen D, Ho L, Ziko M, Bueler SA, Lu S, Tao J, Moser A, Lee R, Agard D, Fairn G, Rubinstein JL, Shoichet BK, Nodwell JR. Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference. Acs Chemical Biology. PMID 26352211 DOI: 10.1021/Acschembio.5B00612  0.544
2015 Chiu PL, Li X, Li Z, Beckett B, Brilot AF, Grigorieff N, Agard DA, Cheng Y, Walz T. Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0. Journal of Structural Biology. PMID 26318383 DOI: 10.1016/J.Jsb.2015.08.015  0.576
2015 Sattin S, Tao J, Vettoretti G, Moroni E, Pennati M, Lopergolo A, Morelli L, Bugatti A, Zuehlke A, Moses M, Prince T, Kijima T, Beebe K, Rusnati M, Neckers L, ... ... Agard DA, et al. Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 13598-608. PMID 26286886 DOI: 10.1002/Chem.201502211  0.327
2015 Peng Y, Moritz M, Han X, Giddings TH, Lyon A, Kollman J, Winey M, Yates J, Agard DA, Drubin DG, Barnes G. Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning. Molecular Biology of the Cell. 26: 2505-18. PMID 25971801 DOI: 10.1091/Mbc.E14-12-1627  0.649
2015 Morgner N, Schmidt C, Beilsten-Edmands V, Ebong IO, Patel NA, Clerico EM, Kirschke E, Daturpalli S, Jackson SE, Agard D, Robinson CV. Hsp70 forms antiparallel dimers stabilized by post-translational modifications to position clients for transfer to Hsp90. Cell Reports. 11: 759-69. PMID 25921532 DOI: 10.1016/J.Celrep.2015.03.063  0.782
2015 Cheng A, Henderson R, Mastronarde D, Ludtke SJ, Schoenmakers RH, Short J, Marabini R, Dallakyan S, Agard D, Winn M. MRC2014: Extensions to the MRC format header for electron cryo-microscopy and tomography. Journal of Structural Biology. PMID 25882513 DOI: 10.1016/J.Jsb.2015.04.002  0.505
2015 Kollman JM, Greenberg CH, Li S, Moritz M, Zelter A, Fong KK, Fernandez JJ, Sali A, Kilmartin J, Davis TN, Agard DA. Ring closure activates yeast γTuRC for species-specific microtubule nucleation. Nature Structural & Molecular Biology. 22: 132-7. PMID 25599398 DOI: 10.1038/Nsmb.2953  0.649
2014 Partridge JR, Lavery LA, Elnatan D, Naber N, Cooke R, Agard DA. A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity. Elife. 3. PMID 25531069 DOI: 10.7554/Elife.03487  0.584
2014 Erb ML, Kraemer JA, Coker JK, Chaikeeratisak V, Nonejuie P, Agard DA, Pogliano J. A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells. Elife. 3. PMID 25429514 DOI: 10.7554/Elife.03197  0.792
2014 Kirschke E, Goswami D, Southworth D, Griffin PR, Agard DA. Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles. Cell. 157: 1685-97. PMID 24949977 DOI: 10.1016/J.Cell.2014.04.038  0.781
2014 Street TO, Zeng X, Pellarin R, Bonomi M, Sali A, Kelly MJ, Chu F, Agard DA. Elucidating the mechanism of substrate recognition by the bacterial Hsp90 molecular chaperone. Journal of Molecular Biology. 426: 2393-404. PMID 24726919 DOI: 10.1016/J.Jmb.2014.04.001  0.377
2014 Schax E, Walter JG, Märzhäuser H, Stahl F, Scheper T, Agard DA, Eichner S, Kirschning A, Zeilinger C. Microarray-based screening of heat shock protein inhibitors. Journal of Biotechnology. 180: 1-9. PMID 24667540 DOI: 10.1016/J.Jbiotec.2014.03.006  0.33
2014 Prestegard JH, Agard DA, Moremen KW, Lavery LA, Morris LC, Pederson K. Sparse labeling of proteins: structural characterization from long range constraints. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 241: 32-40. PMID 24656078 DOI: 10.1016/J.Jmr.2013.12.012  0.585
2014 Zehr EA, Kraemer JA, Erb ML, Coker JK, Montabana EA, Pogliano J, Agard DA. The structure and assembly mechanism of a novel three-stranded tubulin filament that centers phage DNA. Structure (London, England : 1993). 22: 539-48. PMID 24631461 DOI: 10.1016/J.Str.2014.02.006  0.805
2014 Montabana EA, Agard DA. Bacterial tubulin TubZ-Bt transitions between a two-stranded intermediate and a four-stranded filament upon GTP hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. 111: 3407-12. PMID 24550513 DOI: 10.1073/Pnas.1318339111  0.791
2014 Peng LX, Hsu MT, Bonomi M, Agard DA, Jacobson MP. The free energy profile of tubulin straight-bent conformational changes, with implications for microtubule assembly and drug discovery. Plos Computational Biology. 10: e1003464. PMID 24516374 DOI: 10.1371/Journal.Pcbi.1003464  0.342
2014 Lavery LA, Partridge JR, Ramelot TA, Elnatan D, Kennedy MA, Agard DA. Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Molecular Cell. 53: 330-43. PMID 24462206 DOI: 10.1016/J.Molcel.2013.12.023  0.603
2014 Mennella V, Agard DA, Huang B, Pelletier L. Amorphous no more: subdiffraction view of the pericentriolar material architecture. Trends in Cell Biology. 24: 188-97. PMID 24268653 DOI: 10.1016/J.Tcb.2013.10.001  0.346
2014 Partridge JR, Lavery LA, Elnatan D, Naber N, Cooke R, Agard DA. Author response: A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity Elife. DOI: 10.7554/Elife.03487.021  0.515
2014 Erb ML, Kraemer JA, Coker JKC, Chaikeeratisak V, Nonejuie P, Agard DA, Pogliano J. Author response: A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells Elife. DOI: 10.7554/Elife.03197.021  0.762
2013 Miao Y, Wong CC, Mennella V, Michelot A, Agard DA, Holt LJ, Yates JR, Drubin DG. Cell-cycle regulation of formin-mediated actin cable assembly. Proceedings of the National Academy of Sciences of the United States of America. 110: E4446-55. PMID 24133141 DOI: 10.1073/Pnas.1314000110  0.318
2013 Arigovindan M, Fung JC, Elnatan D, Mennella V, Chan YH, Pollard M, Branlund E, Sedat JW, Agard DA. High-resolution restoration of 3D structures from widefield images with extreme low signal-to-noise-ratio. Proceedings of the National Academy of Sciences of the United States of America. 110: 17344-9. PMID 24106307 DOI: 10.1073/Pnas.1315675110  0.581
2013 Li X, Mooney P, Zheng S, Booth CR, Braunfeld MB, Gubbens S, Agard DA, Cheng Y. Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nature Methods. 10: 584-90. PMID 23644547 DOI: 10.1038/Nmeth.2472  0.339
2013 Genest O, Reidy M, Street TO, Hoskins JR, Camberg JL, Agard DA, Masison DC, Wickner S. Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast. Molecular Cell. 49: 464-73. PMID 23260660 DOI: 10.1016/J.Molcel.2012.11.017  0.33
2013 Abrahamsson S, Chen J, Hajj B, Stallinga S, Katsov AY, Wisniewski J, Mizuguchi G, Soule P, Mueller F, Dugast Darzacq C, Darzacq X, Wu C, Bargmann CI, Agard DA, Dahan M, et al. Fast multicolor 3D imaging using aberration-corrected multifocus microscopy. Nature Methods. 10: 60-3. PMID 23223154 DOI: 10.1038/Nmeth.2277  0.723
2013 Ozyamak E, Kollman J, Agard DA, Komeili A. The bacterial actin MamK: in vitro assembly behavior and filament architecture. The Journal of Biological Chemistry. 288: 4265-77. PMID 23204522 DOI: 10.1074/Jbc.M112.417030  0.659
2013 Jaswal SS, Fuhrmann CN, Ota N, Rader SD, Agard DA. α-Lytic Protease Handbook of Proteolytic Enzymes. 3: 2558-2565. DOI: 10.1016/B978-0-12-382219-2.00567-6  0.484
2012 Schneidman-Duhovny D, Rossi A, Avila-Sakar A, Kim SJ, Velázquez-Muriel J, Strop P, Liang H, Krukenberg KA, Liao M, Kim HM, Sobhanifar S, Dötsch V, Rajpal A, Pons J, Agard DA, et al. A method for integrative structure determination of protein-protein complexes. Bioinformatics (Oxford, England). 28: 3282-9. PMID 23093611 DOI: 10.1093/Bioinformatics/Bts628  0.767
2012 Mennella V, Keszthelyi B, McDonald KL, Chhun B, Kan F, Rogers GC, Huang B, Agard DA. Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization. Nature Cell Biology. 14: 1159-68. PMID 23086239 DOI: 10.1038/Ncb2597  0.36
2012 Kraemer JA, Erb ML, Waddling CA, Montabana EA, Zehr EA, Wang H, Nguyen K, Pham DS, Agard DA, Pogliano J. A phage tubulin assembles dynamic filaments by an atypical mechanism to center viral DNA within the host cell. Cell. 149: 1488-99. PMID 22726436 DOI: 10.1016/J.Cell.2012.04.034  0.798
2012 Cunningham CN, Southworth DR, Krukenberg KA, Agard DA. The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis. Protein Science : a Publication of the Protein Society. 21: 1162-71. PMID 22653663 DOI: 10.1002/Pro.2103  0.807
2012 Kelch BA, Salimi NL, Agard DA. Functional modulation of a protein folding landscape via side-chain distortion. Proceedings of the National Academy of Sciences of the United States of America. 109: 9414-9. PMID 22635267 DOI: 10.1073/Pnas.1119274109  0.786
2012 Shao L, Winoto L, Agard DA, Gustafsson MG, Sedat JW. Interferometer-based structured-illumination microscopy utilizing complementary phase relationship through constructive and destructive image detection by two cameras. Journal of Microscopy. 246: 229-36. PMID 22472010 DOI: 10.1111/J.1365-2818.2012.03604.X  0.663
2012 Arigovindan M, Sedat JW, Agard DA. Effect of depth dependent spherical aberrations in 3D structured illumination microscopy. Optics Express. 20: 6527-41. PMID 22418536 DOI: 10.1364/Oe.20.006527  0.563
2012 Li S, Fernandez JJ, Marshall WF, Agard DA. Three-dimensional structure of basal body triplet revealed by electron cryo-tomography. The Embo Journal. 31: 552-62. PMID 22157822 DOI: 10.1038/Emboj.2011.460  0.564
2012 Street TO, Lavery LA, Verba KA, Lee CT, Mayer MP, Agard DA. Cross-monomer substrate contacts reposition the Hsp90 N-terminal domain and prime the chaperone activity. Journal of Molecular Biology. 415: 3-15. PMID 22063096 DOI: 10.1016/J.Jmb.2011.10.038  0.8
2012 Agard D. Conformational Dynamics, Structure & Substrate Protein Interactions of Hsp90 Chaperones Biophysical Journal. 102: 428a. DOI: 10.1016/J.Bpj.2011.11.2341  0.363
2011 Alexander LD, Partridge JR, Agard DA, McAlpine SR. A small molecule that preferentially binds the closed conformation of Hsp90. Bioorganic & Medicinal Chemistry Letters. 21: 7068-71. PMID 22014826 DOI: 10.1016/J.Bmcl.2011.09.096  0.302
2011 Kollman JM, Merdes A, Mourey L, Agard DA. Microtubule nucleation by γ-tubulin complexes. Nature Reviews. Molecular Cell Biology. 12: 709-21. PMID 21993292 DOI: 10.1038/Nrm3209  0.673
2011 Zheng SQ, Branlund E, Kesthelyi B, Braunfeld MB, Cheng Y, Sedat JW, Agard DA. A distributed multi-GPU system for high speed electron microscopic tomographic reconstruction. Ultramicroscopy. 111: 1137-43. PMID 21741915 DOI: 10.1016/J.Ultramic.2011.03.015  0.544
2011 Guillet V, Knibiehler M, Gregory-Pauron L, Remy MH, Chemin C, Raynaud-Messina B, Bon C, Kollman JM, Agard DA, Merdes A, Mourey L. Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation. Nature Structural & Molecular Biology. 18: 915-9. PMID 21725292 DOI: 10.1038/Nsmb.2083  0.686
2011 Southworth DR, Agard DA. Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex. Molecular Cell. 42: 771-81. PMID 21700222 DOI: 10.1016/J.Molcel.2011.04.023  0.37
2011 Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP, Agard DA, Avidor-Reiss T. Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nature Communications. 2: 359. PMID 21694707 DOI: 10.1038/Ncomms1367  0.339
2011 Street TO, Lavery LA, Agard DA. Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone. Molecular Cell. 42: 96-105. PMID 21474071 DOI: 10.1016/J.Molcel.2011.01.029  0.605
2011 Krukenberg KA, Street TO, Lavery LA, Agard DA. Conformational dynamics of the molecular chaperone Hsp90. Quarterly Reviews of Biophysics. 44: 229-55. PMID 21414251 DOI: 10.1017/S0033583510000314  0.803
2011 Rivera CR, Kollman JM, Polka JK, Agard DA, Mullins RD. Architecture and assembly of a divergent member of the ParM family of bacterial actin-like proteins. The Journal of Biological Chemistry. 286: 14282-90. PMID 21339292 DOI: 10.1074/Jbc.M110.203828  0.652
2011 Kner P, Kam Z, Agard D, Sedat J. Adaptive optics in wide-field microscopy Proceedings of Spie - the International Society For Optical Engineering. 7931. DOI: 10.1117/12.876500  0.688
2011 Street TO, Lavery L, Agard DA. Elucidating the Mechanism of Protein Remodeling by the Hsp90 Molecular Chaperone Biophysical Journal. 100: 390a. DOI: 10.1016/J.Bpj.2010.12.2318  0.615
2010 Kner P, Winoto L, Agard DA, Sedat JW. Closed loop adaptive optics for microscopy without a wavefront sensor. Proceedings of Spie--the International Society For Optical Engineering. 7570. PMID 24392198 DOI: 10.1117/12.840943  0.731
2010 Zheng SQ, Sedat JW, Agard DA. Automated data collection for electron microscopic tomography. Methods in Enzymology. 481: 283-315. PMID 20887862 DOI: 10.1016/S0076-6879(10)81012-2  0.551
2010 Matsuda A, Shao L, Boulanger J, Kervrann C, Carlton PM, Kner P, Agard D, Sedat JW. Condensed mitotic chromosome structure at nanometer resolution using PALM and EGFP- histones. Plos One. 5: e12768. PMID 20856676 DOI: 10.1371/Journal.Pone.0012768  0.782
2010 Vasko RC, Rodriguez RA, Cunningham CN, Ardi VC, Agard DA, McAlpine SR. Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90. Acs Medicinal Chemistry Letters. 1: 4-8. PMID 20730035 DOI: 10.1021/Ml900003T  0.751
2010 Carlton PM, Boulanger J, Kervrann C, Sibarita JB, Salamero J, Gordon-Messer S, Bressan D, Haber JE, Haase S, Shao L, Winoto L, Matsuda A, Kner P, Uzawa S, Gustafsson M, ... ... Agard DA, et al. Fast live simultaneous multiwavelength four-dimensional optical microscopy. Proceedings of the National Academy of Sciences of the United States of America. 107: 16016-22. PMID 20705899 DOI: 10.1073/Pnas.1004037107  0.795
2010 Kollman JM, Polka JK, Zelter A, Davis TN, Agard DA. Microtubule nucleating gamma-TuSC assembles structures with 13-fold microtubule-like symmetry. Nature. 466: 879-82. PMID 20631709 DOI: 10.1038/Nature09207  0.667
2010 Arigovindan M, Shaevitz J, McGowan J, Sedat JW, Agard DA. A Parallel Product-Convolution approach for representing the depth varying Point Spread Functions in 3D widefield microscopy based on principal component analysis. Optics Express. 18: 6461-76. PMID 20389670 DOI: 10.1364/Oe.18.006461  0.568
2010 Xu W, Xu F, Jones M, Keszthelyi B, Sedat J, Agard D, Mueller K. High-performance iterative electron tomography reconstruction with long-object compensation using graphics processing units (GPUs). Journal of Structural Biology. 171: 142-53. PMID 20371381 DOI: 10.1016/J.Jsb.2010.03.018  0.533
2010 Salimi NL, Ho B, Agard DA. Unfolding simulations reveal the mechanism of extreme unfolding cooperativity in the kinetically stable alpha-lytic protease. Plos Computational Biology. 6: e1000689. PMID 20195497 DOI: 10.1371/Journal.Pcbi.1000689  0.794
2010 Kner P, Sedat JW, Agard DA, Kam Z. High-resolution wide-field microscopy with adaptive optics for spherical aberration correction and motionless focusing. Journal of Microscopy. 237: 136-47. PMID 20096044 DOI: 10.1111/J.1365-2818.2009.03315.X  0.74
2010 Gopalakrishnan J, Guichard P, Smith AH, Schwarz H, Agard DA, Marco S, Avidor-Reiss T. Self-assembling SAS-6 multimer is a core centriole building block. The Journal of Biological Chemistry. 285: 8759-70. PMID 20083610 DOI: 10.1074/Jbc.M109.092627  0.342
2010 Ho BK, Agard DA. Conserved tertiary couplings stabilize elements in the PDZ fold, leading to characteristic patterns of domain conformational flexibility. Protein Science : a Publication of the Protein Society. 19: 398-411. PMID 20052683 DOI: 10.1002/Pro.318  0.334
2010 Street TO, Krukenberg KA, Rosgen J, Bolen DW, Agard DA. Osmolyte-induced conformational changes in the Hsp90 molecular chaperone. Protein Science : a Publication of the Protein Society. 19: 57-65. PMID 19890989 DOI: 10.1002/Pro.282  0.765
2010 Xu F, Xu W, Jones M, Keszthelyi B, Sedat J, Agard D, Mueller K. On the efficiency of iterative ordered subset reconstruction algorithms for acceleration on GPUs. Computer Methods and Programs in Biomedicine. 98: 261-70. PMID 19850372 DOI: 10.1016/J.Cmpb.2009.09.003  0.527
2009 Choy RM, Kollman JM, Zelter A, Davis TN, Agard DA. Localization and orientation of the gamma-tubulin small complex components using protein tags as labels for single particle EM. Journal of Structural Biology. 168: 571-4. PMID 19723581 DOI: 10.1016/J.Jsb.2009.08.012  0.795
2009 Polka JK, Kollman JM, Agard DA, Mullins RD. The structure and assembly dynamics of plasmid actin AlfA imply a novel mechanism of DNA segregation. Journal of Bacteriology. 191: 6219-30. PMID 19666709 DOI: 10.1128/Jb.00676-09  0.665
2009 Krukenberg KA, Böttcher UM, Southworth DR, Agard DA. Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide. Protein Science : a Publication of the Protein Society. 18: 1815-27. PMID 19554567 DOI: 10.1002/Pro.191  0.758
2009 Zheng SQ, Matsuda A, Braunfeld MB, Sedat JW, Agard DA. Dual-axis target mapping and automated sequential acquisition of dual-axis EM tomographic data. Journal of Structural Biology. 168: 323-31. PMID 19545637 DOI: 10.1016/J.Jsb.2009.06.010  0.547
2009 Krukenberg KA, Southworth DR, Street TO, Agard DA. pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation. Journal of Molecular Biology. 390: 278-91. PMID 19427321 DOI: 10.1016/J.Jmb.2009.04.080  0.753
2009 Ho BK, Agard DA. Probing the flexibility of large conformational changes in protein structures through local perturbations. Plos Computational Biology. 5: e1000343. PMID 19343225 DOI: 10.1371/Journal.Pcbi.1000343  0.366
2009 Sedat J, Agard D, Kam Z, Boulange J, Carlton P, Shao L, Kner P, Matsuda A. S09-04 OMX, a new microscope platform for increased time and spatial resolution Mechanisms of Development. 126: S36. DOI: 10.1016/J.Mod.2009.06.1036  0.748
2008 Southworth DR, Agard DA. Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle. Molecular Cell. 32: 631-40. PMID 19061638 DOI: 10.1016/J.Molcel.2008.10.024  0.347
2008 Förster F, Webb B, Krukenberg KA, Tsuruta H, Agard DA, Sali A. Integration of small-angle X-ray scattering data into structural modeling of proteins and their assemblies. Journal of Molecular Biology. 382: 1089-106. PMID 18694757 DOI: 10.1016/J.Jmb.2008.07.074  0.765
2008 Schermelleh L, Carlton PM, Haase S, Shao L, Winoto L, Kner P, Burke B, Cardoso MC, Agard DA, Gustafsson MG, Leonhardt H, Sedat JW. Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science (New York, N.Y.). 320: 1332-6. PMID 18535242 DOI: 10.1126/Science.1156947  0.797
2008 Nölting B, Agard DA. How general is the nucleation-condensation mechanism? Proteins. 73: 754-64. PMID 18498109 DOI: 10.1002/Prot.22099  0.391
2008 Cunningham CN, Krukenberg KA, Agard DA. Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90. The Journal of Biological Chemistry. 283: 21170-8. PMID 18492664 DOI: 10.1074/Jbc.M800046200  0.806
2008 Krukenberg KA, Förster F, Rice LM, Sali A, Agard DA. Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90. Structure (London, England : 1993). 16: 755-65. PMID 18462680 DOI: 10.1016/J.Str.2008.01.021  0.8
2008 Trammell MA, Mahoney NM, Agard DA, Vale RD. Mob4 plays a role in spindle focusing in Drosophila S2 cells. Journal of Cell Science. 121: 1284-92. PMID 18388316 DOI: 10.1242/Jcs.017210  0.79
2008 Rice LM, Montabana EA, Agard DA. The lattice as allosteric effector: structural studies of alphabeta- and gamma-tubulin clarify the role of GTP in microtubule assembly. Proceedings of the National Academy of Sciences of the United States of America. 105: 5378-83. PMID 18388201 DOI: 10.1073/Pnas.0801155105  0.806
2008 Gustafsson MG, Shao L, Carlton PM, Wang CJ, Golubovskaya IN, Cande WZ, Agard DA, Sedat JW. Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination. Biophysical Journal. 94: 4957-70. PMID 18326650 DOI: 10.1529/Biophysj.107.120345  0.759
2008 Shao L, Isaac B, Uzawa S, Agard DA, Sedat JW, Gustafsson MG. I5S: wide-field light microscopy with 100-nm-scale resolution in three dimensions. Biophysical Journal. 94: 4971-83. PMID 18326649 DOI: 10.1529/Biophysj.107.120352  0.746
2008 Kollman JM, Zelter A, Muller EG, Fox B, Rice LM, Davis TN, Agard DA. The structure of the gamma-tubulin small complex: implications of its architecture and flexibility for microtubule nucleation. Molecular Biology of the Cell. 19: 207-15. PMID 17978090 DOI: 10.1091/Mbc.E07-09-0879  0.768
2008 Kner P, Sedat J, Agard D, Kam Z. Applying adaptive optics to three-dimensional wide-field microscopy Proceedings of Spie - the International Society For Optical Engineering. 6888. DOI: 10.1117/12.773731  0.695
2008 Zheng SQ, Braunfeld MB, Sedat JW, Agard DA. Serial acquisition of dual axis EM tomographic data Microscopy and Microanalysis. 14: 1320-1321. DOI: 10.1017/S1431927608083530  0.526
2007 Kelch BA, Agard DA. Mesophile versus thermophile: insights into the structural mechanisms of kinetic stability. Journal of Molecular Biology. 370: 784-95. PMID 17543987 DOI: 10.1016/J.Jmb.2007.04.078  0.735
2007 Hom EF, Marchis F, Lee TK, Haase S, Agard DA, Sedat JW. AIDA: an adaptive image deconvolution algorithm with application to multi-frame and three-dimensional data. Journal of the Optical Society of America. a, Optics, Image Science, and Vision. 24: 1580-600. PMID 17491626 DOI: 10.1364/Josaa.24.001580  0.776
2007 Kelch BA, Eagen KP, Erciyas FP, Humphris EL, Thomason AR, Mitsuiki S, Agard DA. Structural and mechanistic exploration of acid resistance: kinetic stability facilitates evolution of extremophilic behavior. Journal of Molecular Biology. 368: 870-83. PMID 17382344 DOI: 10.1016/J.Jmb.2007.02.032  0.716
2007 Kam Z, Kner P, Agard D, Sedat JW. Modelling the application of adaptive optics to wide-field microscope live imaging. Journal of Microscopy. 226: 33-42. PMID 17381707 DOI: 10.1111/J.1365-2818.2007.01751.X  0.732
2007 König P, Braunfeld MB, Sedat JW, Agard DA. The three-dimensional structure of in vitro reconstituted Xenopus laevis chromosomes by EM tomography. Chromosoma. 116: 349-72. PMID 17333236 DOI: 10.1007/S00412-007-0101-0  0.565
2007 Zheng SQ, Kollman JM, Braunfeld MB, Sedat JW, Agard DA. Automated acquisition of electron microscopic random conical tilt sets. Journal of Structural Biology. 157: 148-55. PMID 17169745 DOI: 10.1016/J.Jsb.2006.10.026  0.725
2007 Zheng SQ, Keszthelyi B, Branlund E, Lyle JM, Braunfeld MB, Sedat JW, Agard DA. UCSF tomography: an integrated software suite for real-time electron microscopic tomographic data collection, alignment, and reconstruction. Journal of Structural Biology. 157: 138-47. PMID 16904341 DOI: 10.1016/J.Jsb.2006.06.005  0.555
2007 Moss WC, Haase S, Lyle JM, Agard DA, Sedat JW. Reply to letter to the editor Journal of Microscopy. 225: 108. DOI: 10.1111/j.1365-2818.2007.01734.x  0.418
2006 Shiau AK, Harris SF, Southworth DR, Agard DA. Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell. 127: 329-40. PMID 17055434 DOI: 10.1016/J.Cell.2006.09.027  0.387
2006 Zheng SQ, Braunfeld MB, Keszthelyi B, Branlund E, Kollman JM, Sedat JW, Agard DA. Automated acquisition of tomographic and random conical tilt series and real-time reconstruction using UCSF tmography Microscopy and Microanalysis. 12: 88-89. DOI: 10.1017/S1431927606065871  0.691
2005 Moss WC, Haase S, Lyle JM, Agard DA, Sedat JW. A novel 3D wavelet-based filter for visualizing features in noisy biological data. Journal of Microscopy. 219: 43-9. PMID 16159339 DOI: 10.1111/J.1365-2818.2005.01492.X  0.533
2005 Truhlar SM, Agard DA. The folding landscape of an alpha-lytic protease variant reveals the role of a conserved beta-hairpin in the development of kinetic stability. Proteins. 61: 105-14. PMID 16044461 DOI: 10.1002/Prot.20525  0.783
2005 Ota N, Agard DA. Intramolecular signaling pathways revealed by modeling anisotropic thermal diffusion. Journal of Molecular Biology. 351: 345-54. PMID 16005893 DOI: 10.1016/J.Jmb.2005.05.043  0.303
2005 Aldaz H, Rice LM, Stearns T, Agard DA. Insights into microtubule nucleation from the crystal structure of human gamma-tubulin. Nature. 435: 523-7. PMID 15917813 DOI: 10.1038/Nature03586  0.789
2005 Jaswal SS, Truhlar SM, Dill KA, Agard DA. Comprehensive analysis of protein folding activation thermodynamics reveals a universal behavior violated by kinetically stable proteases. Journal of Molecular Biology. 347: 355-66. PMID 15740746 DOI: 10.1016/J.Jmb.2005.01.032  0.786
2004 Hanser BM, Gustafsson MG, Agard DA, Sedat JW. Phase-retrieved pupil functions in wide-field fluorescence microscopy. Journal of Microscopy. 216: 32-48. PMID 15369481 DOI: 10.1111/J.0022-2720.2004.01393.X  0.78
2004 Harris SF, Shiau AK, Agard DA. The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site. Structure (London, England : 1993). 12: 1087-97. PMID 15274928 DOI: 10.1016/J.Str.2004.03.020  0.385
2004 Zheng QS, Braunfeld MB, Sedat JW, Agard DA. An improved strategy for automated electron microscopic tomography. Journal of Structural Biology. 147: 91-101. PMID 15193638 DOI: 10.1016/J.Jsb.2004.02.005  0.561
2004 Fuhrmann CN, Kelch BA, Ota N, Agard DA. The 0.83 A resolution crystal structure of alpha-lytic protease reveals the detailed structure of the active site and identifies a source of conformational strain. Journal of Molecular Biology. 338: 999-1013. PMID 15111063 DOI: 10.1016/J.Jmb.2004.03.018  0.725
2004 Cunningham EL, Agard DA. Disabling the folding catalyst is the last critical step in alpha-lytic protease folding. Protein Science : a Publication of the Protein Society. 13: 325-31. PMID 14739318 DOI: 10.1110/Ps.03389704  0.725
2004 Truhlar SM, Cunningham EL, Agard DA. The folding landscape of Streptomyces griseus protease B reveals the energetic costs and benefits associated with evolving kinetic stability. Protein Science : a Publication of the Protein Society. 13: 381-90. PMID 14718653 DOI: 10.1110/Ps.03336804  0.781
2004 Bailey B, Agard DA, Sedat JW, Barfels M, Chao H, Mooney PE. Performance evaluation of a transmission scintillator-based lens-coupled 4K CCD camera for use in low-dose electron cryo-microscopy Microscopy and Microanalysis. 10: 1204-1205. DOI: 10.1017/S1431927604886458  0.525
2004 Gustafsson MGL, Shao L, Agard DA, Sedat JW. Fluorescence microscopy without resolution limit Leos Summer Topical Meeting. 25-26.  0.492
2003 Cunningham EL, Agard DA. Interdependent folding of the N- and C-terminal domains defines the cooperative folding of alpha-lytic protease. Biochemistry. 42: 13212-9. PMID 14609332 DOI: 10.1021/Bi035409Q  0.73
2003 Hanser BM, Gustafsson MG, Agard DA, Sedat JW. Phase retrieval for high-numerical-aperture optical systems. Optics Letters. 28: 801-3. PMID 12779151 DOI: 10.1364/Ol.28.000801  0.775
2002 Chen CY, Reese ML, Hwang PK, Ota N, Agard D, Brodsky FM. Clathrin light and heavy chain interface: alpha-helix binding superhelix loops via critical tryptophans. The Embo Journal. 21: 6072-82. PMID 12426379 DOI: 10.1093/Emboj/Cdf594  0.352
2002 Rice LM, Agard DA. Centriole duplication: centrin in on answers? Current Biology : Cb. 12: R618-9. PMID 12372266 DOI: 10.1016/S0960-9822(02)01133-8  0.636
2002 Cunningham EL, Mau T, Truhlar SM, Agard DA. The pro region N-terminal domain provides specific interactions required for catalysis of alpha-lytic protease folding. Biochemistry. 41: 8860-7. PMID 12102628 DOI: 10.1021/Bi020214O  0.78
2002 Wille H, Michelitsch MD, Guenebaut V, Supattapone S, Serban A, Cohen FE, Agard DA, Prusiner SB. Structural studies of the scrapie prion protein by electron crystallography. Proceedings of the National Academy of Sciences of the United States of America. 99: 3563-8. PMID 11891310 DOI: 10.1073/Pnas.052703499  0.366
2002 Jaswal SS, Sohl JL, Davis JH, Agard DA. Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability. Nature. 415: 343-6. PMID 11797014 DOI: 10.1038/415343A  0.609
2002 Hanser BM, Gustafsson MGL, Agard DA, Sedat JW. Application of phase retrieved pupil functions in wide-field fluorescence microscopy Proceedings of Spie - the International Society For Optical Engineering. 4621: 40-46. DOI: 10.1117/12.467844  0.77
2001 Ota N, Agard DA. Binding mode prediction for a flexible ligand in a flexible pocket using multi-conformation simulated annealing pseudo crystallographic refinement. Journal of Molecular Biology. 314: 607-17. PMID 11846570 DOI: 10.1006/Jmbi.2001.5147  0.314
2001 Tonelli M, Peters RJ, James TL, Agard DA. The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus. Febs Letters. 509: 161-8. PMID 11768384 DOI: 10.1016/S0014-5793(01)03086-1  0.314
2001 Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T. GCP5 and GCP6: two new members of the human gamma-tubulin complex. Molecular Biology of the Cell. 12: 3340-52. PMID 11694571 DOI: 10.1091/Mbc.12.11.3340  0.313
2001 Moritz M, Braunfeld MB, Alberts BM, Agard DA. Reconstitution of centrosome microtubule nucleation in Drosophila. Methods in Cell Biology. 67: 141-8. PMID 11550465 DOI: 10.1016/S0091-679X(01)67010-9  0.357
2001 Ota N, Agard DA. Enzyme specificity under dynamic control II: Principal component analysis of alpha-lytic protease using global and local solvent boundary conditions. Protein Science : a Publication of the Protein Society. 10: 1403-14. PMID 11420442 DOI: 10.1110/Ps.800101  0.311
2001 Marshall WF, Marko JF, Agard DA, Sedat JW. Chromosome elasticity and mitotic polar ejection force measured in living Drosophila embryos by four-dimensional microscopy-based motion analysis. Current Biology : Cb. 11: 569-78. PMID 11369201 DOI: 10.1016/S0960-9822(01)00180-4  0.667
2001 Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Current Opinion in Structural Biology. 11: 174-81. PMID 11297925 DOI: 10.1016/S0959-440X(00)00187-1  0.32
2001 Kam Z, Hanser B, Gustafsson MG, Agard DA, Sedat JW. Computational adaptive optics for live three-dimensional biological imaging. Proceedings of the National Academy of Sciences of the United States of America. 98: 3790-5. PMID 11274396 DOI: 10.1073/Pnas.071275698  0.785
2001 Hanser BM, Gustafsson MGL, Agard DA, Sedat JW. Phase retrieval of widefield microscopy point spread functions Proceedings of Spie - the International Society For Optical Engineering. 4261: 60-68. DOI: 10.1117/12.424520  0.768
2000 Moritz M, Braunfeld MB, Guénebaut V, Heuser J, Agard DA. Structure of the gamma-tubulin ring complex: a template for microtubule nucleation. Nature Cell Biology. 2: 365-70. PMID 10854328 DOI: 10.1038/35014058  0.347
2000 Bass HW, Riera-Lizarazu O, Ananiev EV, Bordoli SJ, Rines HW, Phillips RL, Sedat JW, Agard DA, Cande WZ. Evidence for the coincident initiation of homolog pairing and synapsis during the telomere-clustering (bouquet) stage of meiotic prophase. Journal of Cell Science. 113: 1033-42. PMID 10683151  0.521
2000 Gustafsson MGL, Agard DA, Sedat JW. Doubling the lateral resolution of wide-field fluorescence microscopy using structured illumination Proceedings of Spie - the International Society For Optical Engineering. 3919: 141-150.  0.691
1999 Cunningham EL, Jaswal SS, Sohl JL, Agard DA. Kinetic stability as a mechanism for protease longevity. Proceedings of the National Academy of Sciences of the United States of America. 96: 11008-14. PMID 10500115 DOI: 10.1073/Pnas.96.20.11008  0.79
1999 Gustafsson MG, Agard DA, Sedat JW. I5M: 3D widefield light microscopy with better than 100 nm axial resolution. Journal of Microscopy. 195: 10-6. PMID 10444297 DOI: 10.1046/J.1365-2818.1999.00576.X  0.554
1998 Sauter NK, Mau T, Rader SD, Agard DA. Structure of alpha-lytic protease complexed with its pro region. Nature Structural Biology. 5: 945-50. PMID 9808037 DOI: 10.1038/2919  0.348
1998 Sohl JL, Jaswal SS, Agard DA. Unfolded conformations of alpha-lytic protease are more stable than its native state. Nature. 395: 817-9. PMID 9796818 DOI: 10.1038/27470  0.596
1998 Davis JH, Agard DA. Relationship between enzyme specificity and the backbone dynamics of free and inhibited alpha-lytic protease. Biochemistry. 37: 7696-707. PMID 9601029 DOI: 10.1021/Bi972963P  0.31
1998 Fung JC, Marshall WF, Dernburg A, Agard DA, Sedat JW. Homologous chromosome pairing in Drosophila melanogaster proceeds through multiple independent initiations. The Journal of Cell Biology. 141: 5-20. PMID 9531544 DOI: 10.1083/Jcb.141.1.5  0.664
1997 Han KF, Sedat JW, Agard DA. Practical image restoration of thick biological specimens using multiple focus levels in transmission electron microscopy. Journal of Structural Biology. 120: 237-44. PMID 9441929 DOI: 10.1006/Jsbi.1997.3914  0.576
1997 Marshall WF, Straight A, Marko JF, Swedlow J, Dernburg A, Belmont A, Murray AW, Agard DA, Sedat JW. Interphase chromosomes undergo constrained diffusional motion in living cells. Current Biology : Cb. 7: 930-9. PMID 9382846 DOI: 10.1016/S0960-9822(06)00412-X  0.785
1997 Davis JH, Agard DA, Handel TM, Basus VJ. Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to alpha-lytic protease. Journal of Biomolecular Nmr. 10: 21-7. PMID 9335113 DOI: 10.1023/A:1018314808361  0.338
1997 Rader SD, Agard DA. Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution. Protein Science : a Publication of the Protein Society. 6: 1375-86. PMID 9232638 DOI: 10.1002/Pro.5560060701  0.329
1997 Bass HW, Marshall WF, Sedat JW, Agard DA, Cande WZ. Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. The Journal of Cell Biology. 137: 5-18. PMID 9105032 DOI: 10.1083/Jcb.137.1.5  0.773
1997 Fung JC, Kane L, Smith SD, Sedat JW, Agard DA, Spontak RJ. Phase behavior of complex diblock copolymer blends: A transmission electron microscopy study Materials Science Forum. 239: 179-184. DOI: 10.4028/Www.Scientific.Net/Msf.239-241.179  0.538
1997 Laurer JH, Hajduk DA, Fung JC, Sedat JW, Smith SD, Gruner SM, Agard DA, Spontak RJ. Microstructural analysis of a cubic bicontinuous morphology in a neat SIS triblock copolymer Macromolecules. 30: 3938-3941. DOI: 10.1021/Ma970449L  0.498
1997 Laurer JH, Fung JC, Sedat JW, Smith SD, Samseth J, Mortensen K, Agard DA, Spontak RJ. From micelles to randomly connected, bilayered membranes in dilute block copolymer blends Langmuir. 13: 2177-2180. DOI: 10.1021/La9608876  0.547
1997 Agard DA, Braunfeld MB, Chen H, McQuitty R, Sedat J. Approaches for High Resolution Cryo-Electron Tomography of Biological Specimens Microscopy and Microanalysis. 3: 1111-1112. DOI: 10.1017/S1431927600012447  0.541
1997 Gustafsson MGL, Agard DA, Sedat JW. Sub-100nm Axial Resolution in 3D Widefield Optical Microscopy Using Two Opposing Objective Lenses Microscopy and Microanalysis. 3: 801-802. DOI: 10.1017/S1431927600010898  0.528
1997 Agard DA, Guenbaut V, Moritz M, Braunfeld MB, Zhang G, Sedat JW. Structure of Centrosomes and Chromosomes Through IVEM Tomography Microscopy and Microanalysis. 3: 223-224. DOI: 10.1017/S143192760000800X  0.554
1997 Sedat J, Marshall W, Dernburg A, Fung J, Agard D. New Insights Into the Three-Dimensional Structure of the Nucleus and Chromosomes Microscopy and Microanalysis. 3: 213-214. DOI: 10.1017/S1431927600007959  0.562
1997 Hiraoka Y, Agard DA, Sedat JW. Spatial arrangement of homologous chromosomes during anaphase in early embryos of Drosophila melanogaster studied by three-dimensional fluorescence microscopy Bioimaging. 5: 183-193. DOI: 10.1002/1361-6374(199712)5:4<183::Aid-Bio2>3.3.Co;2-1  0.553
1997 Kam Z, Agard DA, Sedat JW. Three-dimensional microscopy in thick biological samples: A fresh approach for adjusting focus and correcting spherical aberration Bioimaging. 5: 40-49. DOI: 10.1002/1361-6374(199703)5:1<40::Aid-Bio4>3.3.Co;2-N  0.564
1996 Paddy MR, Saumweber H, Agard DA, Sedat JW. Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos. Journal of Cell Science. 109: 591-607. PMID 8907705  0.553
1996 Han KF, Gubbens AJ, Sedat JW, Agard DA. Optimal strategies for imaging thick biological specimens: exit wavefront reconstruction and energy-filtered imaging. Journal of Microscopy. 183: 124-32. PMID 8805824 DOI: 10.1046/J.1365-2818.1996.810640.X  0.556
1996 Marshall WF, Dernburg AF, Harmon B, Agard DA, Sedat JW. Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster. Molecular Biology of the Cell. 7: 825-42. PMID 8744953 DOI: 10.1091/Mbc.7.5.825  0.787
1996 Fung JC, Liu W, de Ruijter WJ, Chen H, Abbey CK, Sedat JW, Agard DA. Toward fully automated high-resolution electron tomography. Journal of Structural Biology. 116: 181-9. PMID 8742742 DOI: 10.1006/Jsbi.1996.0029  0.552
1996 Chen H, Hughes DD, Chan TA, Sedat JW, Agard DA. IVE (Image Visualization Environment): a software platform for all three-dimensional microscopy applications. Journal of Structural Biology. 116: 56-60. PMID 8742723 DOI: 10.1006/Jsbi.1996.0010  0.542
1996 Dernburg AF, Broman KW, Fung JC, Marshall WF, Philips J, Agard DA, Sedat JW. Perturbation of nuclear architecture by long-distance chromosome interactions. Cell. 85: 745-59. PMID 8646782 DOI: 10.1016/S0092-8674(00)81240-4  0.657
1996 Scalettar BA, Swedlow JR, Sedat JW, Agard DA. Dispersion, aberration and deconvolution in multi-wavelength fluorescence images. Journal of Microscopy. 182: 50-60. PMID 8632447 DOI: 10.1046/J.1365-2818.1996.122402.X  0.576
1996 Spontak RJ, Fung JC, Braunfeld MB, Sedat JW, Agard DA, Ashraf A, Smith SD. Architecture-induced phase immiscibility in a diblock/multiblock copolymer blend Macromolecules. 29: 2850-2856. DOI: 10.1021/Ma9515691  0.52
1996 Spontak RJ, Fung JC, Braunfeld MB, Sedat JW, Agard DA, Kane L, Smith SD, Satkowski MM, Ashraf A, Hajduk DA, Grüner SM. Phase behavior of ordered diblock copolymer blends: Effect of compositional heterogeneity Macromolecules. 29: 4494-4507. DOI: 10.1021/Ma9515689  0.548
1996 Gustafsson MG, Agard DA, Sedat JW. 3D widefield microscopy with two objective lenses: experimental verification of improved axial resolution Proceedings of Spie - the International Society For Optical Engineering. 2655: 62-66.  0.665
1996 Marshall WF, Agard DA, Sedat JW. Chromosome mechanics in vivo: quantitative analysis of nonrigid 3D chromosome motion in Drosophila embryos Proceedings of Spie - the International Society For Optical Engineering. 2678: 142-150.  0.611
1995 Moritz M, Braunfeld MB, Sedat JW, Alberts B, Agard DA. Microtubule nucleation by gamma-tubulin-containing rings in the centrosome. Nature. 378: 638-40. PMID 8524401 DOI: 10.1038/378638A0  0.579
1995 Han KF, Sedat JW, Agard DA. Mechanism of image formation for thick biological specimens: exit wavefront reconstruction and electron energy-loss spectroscopic imaging. Journal of Microscopy. 178: 107-19. PMID 7783184 DOI: 10.1111/J.1365-2818.1995.Tb03586.X  0.565
1995 Moritz M, Braunfeld MB, Fung JC, Sedat JW, Alberts BM, Agard DA. Three-dimensional structural characterization of centrosomes from early Drosophila embryos. The Journal of Cell Biology. 130: 1149-59. PMID 7657699 DOI: 10.1083/Jcb.130.5.1149  0.59
1995 Mace JE, Wilk BJ, Agard DA. Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity. Journal of Molecular Biology. 251: 116-34. PMID 7643381 DOI: 10.1006/Jmbi.1995.0420  0.304
1995 Urata Y, Parmelee SJ, Agard DA, Sedat JW. A three-dimensional structural dissection of Drosophila polytene chromosomes. The Journal of Cell Biology. 131: 279-95. PMID 7593159 DOI: 10.1083/Jcb.131.2.279  0.547
1995 Mace JE, Agard DA. Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity. Journal of Molecular Biology. 254: 720-36. PMID 7500345 DOI: 10.1006/Jmbi.1995.0650  0.302
1995 Gustafsson MG, Agard DA, Sedat JW. Sevenfold improvement of axial resolution in 3D wide-field microscopy using two objective-lenses Proceedings of Spie - the International Society For Optical Engineering. 2412: 147-156.  0.665
1995 Marshall WF, Agard DA, Sedat JW. Quantitative analysis of chromosome motion in Drosophila melanogaster Proceedings of Spie - the International Society For Optical Engineering. 2412: 33-42.  0.602
1994 Horowitz RA, Agard DA, Sedat JW, Woodcock CL. The three-dimensional architecture of chromatin in situ: electron tomography reveals fibers composed of a continuously variable zig-zag nucleosomal ribbon. The Journal of Cell Biology. 125: 1-10. PMID 8138564 DOI: 10.1083/Jcb.125.1.1  0.558
1994 Dawe RK, Sedat JW, Agard DA, Cande WZ. Meiotic chromosome pairing in maize is associated with a novel chromatin organization. Cell. 76: 901-12. PMID 8124724 DOI: 10.1016/0092-8674(94)90364-6  0.543
1994 Braunfeld MB, Koster AJ, Sedat JW, Agard DA. Cryo automated electron tomography: towards high-resolution reconstructions of plastic-embedded structures. Journal of Microscopy. 174: 75-84. PMID 8051698 DOI: 10.1111/J.1365-2818.1994.Tb03451.X  0.548
1994 Baker D, Agard DA. Kinetics versus thermodynamics in protein folding. Biochemistry. 33: 7505-9. PMID 8011615 DOI: 10.1021/Bi00190A002  0.441
1994 Baker D, Agard DA. Influenza hemagglutinin: kinetic control of protein function. Structure (London, England : 1993). 2: 907-10. PMID 7866741 DOI: 10.1016/S0969-2126(94)00091-3  0.377
1994 Braunfeld MB, Moritz M, Alberts BM, Sedat JW, Agard DA. Three-dimensional reconstruction of isolated centrosomes by automated electron tomography Proceedings - Annual Meeting, Microscopy Society of America. 310-311.  0.477
1993 Baker D, Krukowski AE, Agard DA. Uniqueness and the ab initio phase problem in macromolecular crystallography. Acta Crystallographica. Section D, Biological Crystallography. 49: 186-92. PMID 15299560 DOI: 10.1107/S0907444992008801  0.374
1993 Bystroff C, Baker D, Fletterick RJ, Agard DA. PRISM: application to the solution of two protein structures. Acta Crystallographica. Section D, Biological Crystallography. 49: 440-8. PMID 15299503 DOI: 10.1107/S0907444993004020  0.687
1993 Baker D, Bystroff C, Fletterick RJ, Agard DA. PRISM: topologically constrained phased refinement for macromolecular crystallography. Acta Crystallographica. Section D, Biological Crystallography. 49: 429-39. PMID 15299502 DOI: 10.1107/S0907444993004032  0.665
1993 Wilson C, Gregoret LM, Agard DA. Modeling side-chain conformation for homologous proteins using an energy-based rotamer search. Journal of Molecular Biology. 229: 996-1006. PMID 8445659 DOI: 10.1006/Jmbi.1993.1100  0.334
1993 Hiraoka Y, Dernburg AF, Parmelee SJ, Rykowski MC, Agard DA, Sedat JW. The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis. The Journal of Cell Biology. 120: 591-600. PMID 8425892 DOI: 10.1083/Jcb.120.3.591  0.557
1993 Swedlow JR, Sedat JW, Agard DA. Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy. Cell. 73: 97-108. PMID 8384932 DOI: 10.1016/0092-8674(93)90163-K  0.555
1993 Swedlow JR, Agard DA, Sedat JW. Chromosome structure inside the nucleus. Current Opinion in Cell Biology. 5: 412-6. PMID 8352957 DOI: 10.1016/0955-0674(93)90005-B  0.584
1993 Baker D, Shiau AK, Agard DA. The role of pro regions in protein folding. Current Opinion in Cell Biology. 5: 966-70. PMID 8129949 DOI: 10.1016/0955-0674(93)90078-5  0.421
1993 Baker D, Bystroff C, Krukowski A, Wilson C, Agard D. Connectivity and the phase problem in macromolecular crystallography Acta Crystallographica Section a Foundations of Crystallography. 49: c50-c50. DOI: 10.1107/S0108767378098566  0.623
1993 Kam Z, Jones MO, Chen H, Agard DA, Sedat JW. Design and construction of an optimal illumination system for quantitative wide‐field multi‐dimensional microscopy Bioimaging. 1: 71-81. DOI: 10.1002/1361-6374(199306)1:2<71::Aid-Bio2>3.3.Co;2-R  0.513
1993 Braunfeld MB, Koster AJ, Sedat JW, Agard DA. Properties and dose dependence of embedding media for cryo-automated electron tomography Proceedings - Annual Meeting, Microscopy Society of America. 436-437.  0.466
1993 Koster AJ, Chen H, Clyborne W, Sedat JW, Agard DA. Design and performance of instrumentation for automated single-tilt-axis electron tomography Proceedings - Annual Meeting, Microscopy Society of America. 448-449.  0.471
1992 Baker D, Silen JL, Agard DA. Protease pro region required for folding is a potent inhibitor of the mature enzyme. Proteins. 12: 339-44. PMID 1579568 DOI: 10.1002/Prot.340120406  0.431
1992 Baker D, Sohl JL, Agard DA. A protein-folding reaction under kinetic control. Nature. 356: 263-5. PMID 1552947 DOI: 10.1038/356263A0  0.408
1992 Koster AJ, Chen H, Sedat JW, Agard DA. Automated microscopy for electron tomography. Ultramicroscopy. 46: 207-27. PMID 1481272 DOI: 10.1016/0304-3991(92)90016-D  0.554
1992 Paddy MR, Agard DA, Sedat JW. An extended view of nuclear lamin structure, function, and dynamics. Seminars in Cell Biology. 3: 255-66. PMID 1421171 DOI: 10.1016/1043-4682(92)90027-S  0.577
1991 Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science (New York, N.Y.). 252: 1817-22. PMID 2063194 DOI: 10.1126/Science.2063194  0.313
1991 Bone R, Fujishige A, Kettner CA, Agard DA. Structural basis for broad specificity in alpha-lytic protease mutants. Biochemistry. 30: 10388-98. PMID 1931963 DOI: 10.1021/Bi00107A005  0.346
1991 Kam Z, Minden JS, Agard DA, Sedat JW, Leptin M. Drosophila gastrulation: analysis of cell shape changes in living embryos by three-dimensional fluorescence microscopy. Development (Cambridge, England). 112: 365-70. PMID 1794308  0.496
1991 Bone R, Agard DA. Mutational remodeling of enzyme specificity. Methods in Enzymology. 202: 643-71. PMID 1784192 DOI: 10.1016/0076-6879(91)02030-D  0.341
1991 Hiraoka Y, Swedlow JR, Paddy MR, Agard DA, Sedat JW. Three-dimensional multiple-wavelength fluorescence microscopy for the structural analysis of biological phenomena. Seminars in Cell Biology. 2: 153-65. PMID 1720334  0.569
1991 HIRAOKA Y, CHEN H, SEDAT JW, AGARD DA. Three-dimensional fluorescence microscopy for the analysis of spatial arrangement of chromosomes. Acta Histochemica Et Cytochemica. 24: 357-365. DOI: 10.1267/Ahc.24.357  0.566
1991 Paddy MR, Swedlow JR, Hiraoka Y, Sedat JW, Agard DA. Time-resolved, multi-wavelength 3-D fluorescence microscopy of nuclear structures Scanning. 13: I2.  0.51
1990 Hiraoka Y, Sedat JW, Agard DA. Determination of three-dimensional imaging properties of a light microscope system. Partial confocal behavior in epifluorescence microscopy. Biophysical Journal. 57: 325-33. PMID 2317554 DOI: 10.1016/S0006-3495(90)82534-0  0.572
1990 Paddy MR, Belmont AS, Saumweber H, Agard DA, Sedat JW. Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery. Cell. 62: 89-106. PMID 2194675 DOI: 10.1016/0092-8674(90)90243-8  0.683
1990 Hiraoka Y, Agard DA, Sedat JW. Temporal and spatial coordination of chromosome movement, spindle formation, and nuclear envelope breakdown during prometaphase in Drosophila melanogaster embryos. The Journal of Cell Biology. 111: 2815-28. PMID 2125300 DOI: 10.1083/Jcb.111.6.2815  0.568
1990 Koshy M, Agard DA, Sedat JW. Solution of Toeplitz systems for the restoration of 3-D optical sectioning microscopy data Proceedings of Spie - the International Society For Optical Engineering. 1205: 64-71.  0.467
1989 Bone R, Silen JL, Agard DA. Structural plasticity broadens the specificity of an engineered protease. Nature. 339: 191-5. PMID 2716847 DOI: 10.1038/339191A0  0.307
1989 Aikens RS, Agard DA, Sedat JW. Solid-state imagers for microscopy. Methods in Cell Biology. 29: 291-313. PMID 2643764 DOI: 10.1016/S0091-679X(08)60199-5  0.551
1989 Hiraoka Y, Minden JS, Swedlow JR, Sedat JW, Agard DA. Focal points for chromosome condensation and decondensation revealed by three-dimensional in vivo time-lapse microscopy. Nature. 342: 293-6. PMID 2509947 DOI: 10.1038/342293A0  0.565
1989 Silen JL, Agard DA. The alpha-lytic protease pro-region does not require a physical linkage to activate the protease domain in vivo. Nature. 341: 462-4. PMID 2507926 DOI: 10.1038/341462A0  0.319
1989 Minden JS, Agard DA, Sedat JW, Alberts BM. Direct cell lineage analysis in Drosophila melanogaster by time-lapse, three-dimensional optical microscopy of living embryos. The Journal of Cell Biology. 109: 505-16. PMID 2503522 DOI: 10.1083/Jcb.109.2.505  0.554
1989 Shaw PJ, Agard DA, Hiraoka Y, Sedat JW. Tilted view reconstruction in optical microscopy. Three-dimensional reconstruction of Drosophila melanogaster embryo nuclei. Biophysical Journal. 55: 101-10. PMID 2495031 DOI: 10.1016/S0006-3495(89)82783-3  0.574
1989 Agard DA, Hiraoka Y, Shaw P, Sedat JW. Fluorescence microscopy in three dimensions. Methods in Cell Biology. 30: 353-77. PMID 2494418 DOI: 10.1016/S0091-679X(08)60986-3  0.578
1989 Belmont AS, Braunfeld MB, Sedat JW, Agard DA. Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro. Chromosoma. 98: 129-43. PMID 2476279 DOI: 10.1007/Bf00291049  0.694
1989 Chen H, Sedat JW, Agard DA. Software and hardware for 3-d gray level image analysis and quantization Proceedings of Spie - the International Society For Optical Engineering. 1161: 31-41. DOI: 10.1117/12.962685  0.476
1989 Agard DA, Hiraoka Y, Sedat JW. Three-dimensional microscopy: Image processing for high resolution subcellular imaging Proceedings of Spie - the International Society For Optical Engineering. 1161: 24-30. DOI: 10.1117/12.962684  0.503
1989 Agard DA, Hiraoka Y, Shaw P, Sedat JW. Chapter 13 Fluorescence Microscopy in Three Dimensions Methods in Cell Biology. 30: 353-374,374a,375-377. DOI: 10.1016/S0091-679X(08)60986-3  0.477
1989 Agard D, Belmont A, Hiroka Y, Paddy M, Sedat J. Structure and function relationships—The diploid nucleus of Cell Differentiation and Development. 27: 107. DOI: 10.1016/0922-3371(89)90339-0  0.689
1988 Agard DA, Hiraoka Y, Sedat JW. Three-dimensional light microscopy of diploid Drosophila chromosomes. Cell Motility and the Cytoskeleton. 10: 18-27. PMID 3141069 DOI: 10.1002/Cm.970100106  0.589
1988 Rykowski MC, Parmelee SJ, Agard DA, Sedat JW. Precise determination of the molecular limits of a polytene chromosome band: regulatory sequences for the Notch gene are in the interband. Cell. 54: 461-72. PMID 3135939 DOI: 10.1016/0092-8674(88)90067-0  0.554
1988 Spontak RJ, Williams MC, Agard DA. Three-dimensional study of cylindrical morphology in a styrene-butadiene-styrene block copolymer Polymer. 29: 387-395. DOI: 10.1016/0032-3861(88)90354-0  0.306
1987 Hiraoka Y, Sedat JW, Agard DA. The use of a charge-coupled device for quantitative optical microscopy of biological structures. Science (New York, N.Y.). 238: 36-41. PMID 3116667 DOI: 10.1126/Science.3116667  0.598
1987 Belmont AS, Sedat JW, Agard DA. A three-dimensional approach to mitotic chromosome structure: evidence for a complex hierarchical organization. The Journal of Cell Biology. 105: 77-92. PMID 3112167 DOI: 10.1083/Jcb.105.1.77  0.707
1985 Thomas GJ, Agard DA. Quantitative analysis of nucleic acids, proteins, and viruses by Raman band deconvolution. Biophysical Journal. 46: 763-8. PMID 6083811 DOI: 10.1016/S0006-3495(84)84074-6  0.311
1984 Gruenbaum Y, Hochstrasser M, Mathog D, Saumweber H, Agard DA, Sedat JW. Spatial organization of the Drosophila nucleus: a three-dimensional cytogenetic study. Journal of Cell Science. Supplement. 1: 223-34. PMID 6442295 DOI: 10.1242/Jcs.1984.Supplement_1.14  0.689
1983 Agard DA, Sedat JW. Three-dimensional architecture of a polytene nucleus. Nature. 302: 676-81. PMID 6403872 DOI: 10.1038/302676A0  0.571
1982 Agard DA, Stroud RM. Linking regions between helices in bacteriorhodopsin revealed. Biophysical Journal. 37: 589-602. PMID 7074187  0.458
1982 Agard DA, Stroud RM. α-Bungaratoxin structure revealed by a rapid method for averaging electron density of non-crystallographically translationally related molecules Acta Crystallographica Section A. 38: 186-194. DOI: 10.1107/S0567739482000436  0.504
1981 Agard DA, Steinberg RA, Stroud RM. Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution. Analytical Biochemistry. 111: 257-68. PMID 7247021 DOI: 10.1016/0003-2697(81)90562-5  0.438
1980 Agard DA, Sedat JW. Three-dimensional analysis of biological specimens utilizing image processing techniques Proceedings of Spie - the International Society For Optical Engineering. 264: 110-117. DOI: 10.1117/12.959792  0.491
1979 Stroud RM, Agard DA. Structure determination of asymmetric membrane profiles using an iterative Fourier method. Biophysical Journal. 25: 495-512. PMID 318062 DOI: 10.1016/S0006-3495(79)85319-9  0.446
1977 Ross MJ, Klymkowsky MW, Agard DA, Stroud RM. Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. Journal of Molecular Biology. 116: 635-59. PMID 563472 DOI: 10.1016/0022-2836(77)90264-9  0.646
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