| Year |
Citation |
Score |
| 2023 |
Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, ... ... Lee E, et al. The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling. Nature Communications. 14: 6173. PMID 37798301 DOI: 10.1038/s41467-023-41836-z |
0.382 |
|
| 2023 |
Spencer ZT, Ng VH, Benchabane H, Siddiqui GS, Duwadi D, Maines B, Bryant JM, Schwarzkopf A, Yuan K, Kassel SN, Mishra A, Pimentel A, Lebensohn AM, Rohatgi R, Gerber SA, ... ... Lee E, et al. The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Nature Communications. 14: 6174. PMID 37798281 DOI: 10.1038/s41467-023-41843-0 |
0.381 |
|
| 2023 |
Pilat JM, Brown RE, Chen Z, Berle NJ, Othon AP, Washington M, Anant SA, Kurokawa S, Ng VH, Thompson JJ, Jacobse J, Goettel JA, Lee E, Choksi YA, Lau KS, et al. SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. The Journal of Clinical Investigation. PMID 37166989 DOI: 10.1172/JCI165988 |
0.337 |
|
| 2023 |
Kassel S, Hanson AJ, Benchabane H, Saito-Diaz K, Cabel CR, Goldsmith L, Taha M, Kanuganti A, Ng VH, Xu G, Ye F, Picker J, Port F, Boutros M, Weiss VL, ... ... Lee E, et al. USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling. Science Signaling. 16: eabn8372. PMID 36749823 DOI: 10.1126/scisignal.abn8372 |
0.426 |
|
| 2022 |
Shen C, Nayak A, Neitzel LR, Yang F, Li B, Williams CH, Hong CC, Ahmed Y, Lee E, Robbins DJ. The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon. The Journal of Biological Chemistry. 102227. PMID 35780831 DOI: 10.1016/j.jbc.2022.102227 |
0.391 |
|
| 2022 |
Peng X, Lai KS, She P, Kang J, Wang T, Li G, Zhou Y, Sun J, Jin D, Xu X, Liao L, Liu J, Lee E, Poss KD, Zhong TP. Corrigendum to 'Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration'. Journal of Molecular Cell Biology. 13: 921. PMID 35092682 DOI: 10.1093/jmcb/mjab064 |
0.305 |
|
| 2021 |
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, ... ... Lee E, et al. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Nature Communications. 12: 5263. PMID 34489457 DOI: 10.1038/s41467-021-25634-z |
0.459 |
|
| 2020 |
Peng X, Lai KS, She P, Kang J, Wang T, Li G, Zhou Y, Sun J, Jin D, Xu X, Liao L, Liu J, Lee E, Poss KD, Zhong TP. Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Journal of Molecular Cell Biology. PMID 33582796 DOI: 10.1093/jmcb/mjaa046 |
0.306 |
|
| 2020 |
Shen C, Nayak A, Melendez RA, Wynn DT, Jackson J, Lee E, Ahmed Y, Robbins DJ. Casein Kinase 1α as a Regulator of Wnt-Driven Cancer. International Journal of Molecular Sciences. 21. PMID 32824859 DOI: 10.3390/Ijms21165940 |
0.52 |
|
| 2020 |
Anthony CC, Robbins DJ, Ahmed Y, Lee E. Nuclear Regulation of Wnt/β-Catenin Signaling: It's a Complex Situation. Genes. 11. PMID 32759724 DOI: 10.3390/Genes11080886 |
0.494 |
|
| 2020 |
Nlandu-Khodo S, Osaki Y, Scarfe L, Yang HC, Phillips-Mignemi M, Tonello J, Saito-Diaz K, Neelisetty S, Ivanova AV, Huffstater T, McMahon RS, Taketo MM, deCaestecker M, Kasinath BS, Harris RC, ... Lee E, et al. Tubular beta-catenin and FoxO3 interactions protect in chronic kidney disease. Jci Insight. PMID 32369448 DOI: 10.1172/Jci.Insight.135454 |
0.483 |
|
| 2019 |
Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α. Biochemistry. PMID 31820934 DOI: 10.1021/Acs.Biochem.9B00891 |
0.465 |
|
| 2019 |
Cabel CR, Alizadeh E, Robbins DJ, Ahmed Y, Lee E, Thorne CA. Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt Signaling in APC-Deficient Cells. Developmental Cell. 49: 827-828. PMID 31211991 DOI: 10.1016/J.Devcel.2019.05.039 |
0.421 |
|
| 2019 |
Xie S, Fu W, Yu G, Hu X, Lai KS, Peng X, Zhou Y, Zhu X, Christov P, Sawyer L, Ni TT, Sulikowski GA, Yang Z, Lee E, Zeng C, et al. Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair. Journal of Molecular Cell Biology. PMID 30925593 DOI: 10.1093/Jmcb/Mjz023 |
0.332 |
|
| 2019 |
Neitzel LR, Spencer ZT, Nayak A, Cselenyi CS, Benchabane H, Youngblood CQ, Zouaoui A, Ng V, Stephens L, Hann T, Patton JG, Robbins D, Ahmed Y, Lee E. Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway. Mechanisms of Development. PMID 30904594 DOI: 10.1016/J.Mod.2019.03.002 |
0.777 |
|
| 2019 |
Thompson JJ, Short SP, Parang B, Brown RE, Li C, Ng VH, Saito-Diaz K, Choksi YA, Washington MK, Smith JJ, Fingleton B, Brand T, Lee E, Coffey RJ, Williams CS. Blood vessel epicardial substance (BVES) reduces LRP6 receptor and cytoplasmic -catenin levels to modulate Wnt signaling and intestinal homeostasis. Carcinogenesis. PMID 30689807 DOI: 10.1093/Carcin/Bgz007 |
0.497 |
|
| 2018 |
Neitzel LR, Broadus MR, Zhang N, Sawyer L, Wallace HA, Merkle JA, Jodoin JN, Sitaram P, Crispi EE, Rork W, Lee LA, Pan D, Gould KL, Page-McCaw A, Lee E. Characterization of a null allele in . Biology Open. PMID 29945873 DOI: 10.1242/Bio.035394 |
0.306 |
|
| 2018 |
Ng VH, Hang BI, Sawyer LM, Neitzel LR, Crispi EE, Rose KL, Popay TM, Zhong A, Lee LA, Tansey WP, Huppert S, Lee E. Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling. Journal of Cell Science. PMID 29678905 DOI: 10.1242/Jcs.210575 |
0.511 |
|
| 2018 |
Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, ... ... Lee E, et al. APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Developmental Cell. 44: 566-581.e8. PMID 29533772 DOI: 10.1016/J.Devcel.2018.02.013 |
0.495 |
|
| 2018 |
Broadus MR, Lee E. Chemical Screening Using Cell-FreeEgg Extract. Cold Spring Harbor Protocols. PMID 29475996 DOI: 10.1101/Pdb.Prot098277 |
0.324 |
|
| 2018 |
Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss W, Rodriguez C, Mehrdad N, Nguyen D, Ayad N, Rai P, Capobianco A, Robbins D. MBRS-64. SURPRISING ROLE FOR WNT SIGNALING IN SONIC HEDGEHOG DRIVEN MEDULLOBLASTOMA Neuro-Oncology. 20: i142-i142. DOI: 10.1093/Neuonc/Noy059.508 |
0.469 |
|
| 2018 |
Thompson JJ, Choksi YA, Brown RE, Short SP, Brand T, Lee E, Williams CS. 829 - Blood Vessel Epicardial Substance (BVES) Coordinately Reduces LRP6 Receptor and Cytoplasmic β-Catenin Levels to Modulate WNT Signaling and Intestinal Homeostasis Gastroenterology. 154: S-172. DOI: 10.1016/S0016-5085(18)30987-9 |
0.391 |
|
| 2017 |
Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ. Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma. Oncogene. PMID 28714964 DOI: 10.1038/Onc.2017.232 |
0.361 |
|
| 2017 |
Nlandu-Khodo S, Neelisetty S, Phillips M, Manolopoulou M, Bhave G, May L, Clark PE, Yang H, Fogo AB, Harris RC, Taketo MM, Lee E, Gewin LS. Blocking TGF-β and β-Catenin Epithelial Crosstalk Exacerbates CKD. Journal of the American Society of Nephrology : Jasn. PMID 28701516 DOI: 10.1681/Asn.2016121351 |
0.353 |
|
| 2017 |
Polosukhina D, Love H, Moses H, Lee E, Zent R, Clark P. Pharmacologic Inhibition of ß-catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor. Oncology Research. PMID 28695795 DOI: 10.3727/096504017X14992942781895 |
0.361 |
|
| 2017 |
Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, ... ... Lee E, et al. Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Science Signaling. 10. PMID 28655862 DOI: 10.1126/Scisignal.Aak9916 |
0.429 |
|
| 2017 |
Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss W, Rodriguez C, Merhdad N, Nguyen D, Ayad N, Rai P, Capobianco A, Robbins DJ. PDTM-03. SURPRISING ROLE FOR WNT SIGNALING IN Trp53-MUTANT SHH MEDULLOBLASTOMA Neuro-Oncology. 19: vi190-vi190. DOI: 10.1093/Neuonc/Nox168.768 |
0.448 |
|
| 2016 |
Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R. Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. Elife. 5. PMID 27996937 DOI: 10.7554/Elife.21459 |
0.522 |
|
| 2016 |
Ma Y, Wang L, Neitzel LR, Loganathan S, Tang N, Qin L, Emily CE, Guo Y, Knapp S, Beauchamp RD, Lee E, Wang J. The MAPK pathway regulates intrinsic resistance to BET inhibitors in colorectal cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27678457 DOI: 10.1158/1078-0432.Ccr-16-0453 |
0.337 |
|
| 2016 |
Hyde AS, Hang BI, Lee E. Reconstitution of the Cytoplasmic Regulation of the Wnt Signaling Pathway Using Xenopus Egg Extracts. Methods in Molecular Biology (Clifton, N.J.). 1481: 101-9. PMID 27590156 DOI: 10.1007/978-1-4939-6393-5_11 |
0.49 |
|
| 2016 |
Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert SS, Lee E. Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Cell Reports. PMID 27210761 DOI: 10.1016/J.Celrep.2016.04.070 |
0.424 |
|
| 2016 |
Astudillo L, da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver KL, Oashi T, Lopes PE, Orton D, Neitzel LR, Lee E, Landgraf R, Robbins DJ, et al. The small molecule IMR-1 inhibits the Notch transcriptional activation complex to suppress tumorigenesis. Cancer Research. PMID 27197169 DOI: 10.1158/0008-5472.Can-16-0061 |
0.411 |
|
| 2016 |
Yang E, Tacchelly-Benites O, Wang Z, Randall MP, Tian A, Benchabane H, Freemantle S, Pikielny C, Tolwinski NS, Lee E, Ahmed Y. Wnt pathway activation by ADP-ribosylation. Nature Communications. 7: 11430. PMID 27138857 DOI: 10.1038/Ncomms11430 |
0.51 |
|
| 2016 |
Wang Z, Tacchelly-Benites O, Yang E, Thorne CA, Nojima H, Lee E, Ahmed Y. Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase. Genetics. PMID 26975665 DOI: 10.1534/Genetics.115.183244 |
0.501 |
|
| 2016 |
Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R. Author response: Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling Elife. DOI: 10.7554/Elife.21459.025 |
0.399 |
|
| 2016 |
Lebensohn AM, Dubey R, Neitzel LR, Tacchelly O, Marceau CD, Bahrami Z, Hansen AG, Ahmed Y, Lee E, Carette J, Rohatgi R. Abstract PR05: Systematic forward genetic screens in haploid human cells reveal new players and regulatory mechanisms in Wnt signaling Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Pr05 |
0.521 |
|
| 2015 |
Bastakoty D, Saraswati S, Cates J, Lee E, Nanney LB, Young PP. Inhibition of Wnt/β-catenin pathway promotes regenerative repair of cutaneous and cartilage injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 4881-92. PMID 26268926 DOI: 10.1096/Fj.15-275941 |
0.356 |
|
| 2015 |
Broadus MR, Yew PR, Hann SR, Lee E. Small-molecule high-throughput screening utilizing Xenopus egg extract. Methods in Molecular Biology (Clifton, N.J.). 1263: 63-73. PMID 25618336 DOI: 10.1007/978-1-4939-2269-7_5 |
0.369 |
|
| 2015 |
Wang L, Ma Y, Lee E, Wang J. Abstract 3529: BET bromodomain proteins regulate the canonical WNT signaling and drug resistance in colorectal cancer Cancer Research. 75: 3529-3529. DOI: 10.1158/1538-7445.Am2015-3529 |
0.514 |
|
| 2014 |
Li B, Flaveny CA, Giambelli C, Fei DL, Han L, Hang BI, Bai F, Pei XH, Nose V, Burlingame O, Capobianco AJ, Orton D, Lee E, Robbins DJ. Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis. Plos One. 9: e101969. PMID 25003333 DOI: 10.1371/Journal.Pone.0101969 |
0.409 |
|
| 2014 |
Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, et al. Pyrvinium attenuates Hedgehog signaling downstream of smoothened. Cancer Research. 74: 4811-21. PMID 24994715 DOI: 10.1158/0008-5472.Can-14-0317 |
0.509 |
|
| 2014 |
Hainline SG, Rickmyre JL, Neitzel LR, Lee LA, Lee E. The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex. Biology Open. 3: 669-76. PMID 24972868 DOI: 10.1242/Bio.20148318 |
0.38 |
|
| 2014 |
Chen TW, Broadus MR, Huppert SS, Lee E. Reconstitution Of β-catenin degradation in Xenopus egg extract. Journal of Visualized Experiments : Jove. PMID 24962160 DOI: 10.3791/51425 |
0.421 |
|
| 2014 |
Wallace HA, Merkle JA, Yu MC, Berg TG, Lee E, Bosco G, Lee LA. TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η. Development (Cambridge, England). 141: 1332-41. PMID 24553286 DOI: 10.1242/Dev.101196 |
0.372 |
|
| 2014 |
Murphy AJ, Pierce J, de Caestecker C, Ayers GD, Zhao A, Krebs JR, Saito-Diaz VK, Lee E, Perantoni AO, de Caestecker MP, Lovvorn HN. CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus. Oncotarget. 5: 386-402. PMID 24481423 DOI: 10.18632/Oncotarget.1566 |
0.357 |
|
| 2014 |
Rodriguez-Blanco J, Bin L, Martin V, Lee E, Rodriguez C, Capobianco A, Robbins DJ. SC-28 * NOVEL INHIBITORS ON HEDGEHOG PATHWAY TO PREVENT MEDULLOBLASTOMA RELAPSE Neuro-Oncology. 16: v203-v203. DOI: 10.1093/Neuonc/Nou275.28 |
0.355 |
|
| 2014 |
Chen TW, Wallace HA, Ahmed Y, Lee E. Wnt Signal Transduction in the Cytoplasm: An Introduction to the Destruction Complex Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. 33-49. DOI: 10.1002/9781118444122.ch3 |
0.341 |
|
| 2013 |
Jodoin JN, Shboul M, Albrecht TR, Lee E, Wagner EJ, Reversade B, Lee LA. The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms. Biology Open. 2: 1390-6. PMID 24285713 DOI: 10.1242/Bio.20136981 |
0.338 |
|
| 2013 |
Tacchelly-Benites O, Wang Z, Yang E, Lee E, Ahmed Y. Toggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexes. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 35: 1063-70. PMID 24105937 DOI: 10.1002/Bies.201300101 |
0.515 |
|
| 2013 |
Xu W, Lacerda L, Debeb BG, Atkinson RL, Solley TN, Li L, Orton D, McMurray JS, Hang BI, Lee E, Klopp AH, Ueno NT, Reuben JM, Krishnamurthy S, Woodward WA. The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer. Plos One. 8: e71508. PMID 24013655 DOI: 10.1371/Journal.Pone.0071508 |
0.36 |
|
| 2013 |
Hao J, Ao A, Zhou L, Murphy CK, Frist AY, Keel JJ, Thorne CA, Kim K, Lee E, Hong CC. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell Reports. 4: 898-904. PMID 24012757 DOI: 10.1016/J.Celrep.2013.07.047 |
0.455 |
|
| 2013 |
Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE. Targeting the Wnt pathway in synovial sarcoma models. Cancer Discovery. 3: 1286-301. PMID 23921231 DOI: 10.1158/2159-8290.Cd-13-0138 |
0.428 |
|
| 2013 |
Jodoin JN, Sitaram P, Albrecht TR, May SB, Shboul M, Lee E, Reversade B, Wagner EJ, Lee LA. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Molecular Biology of the Cell. 24: 2954-65. PMID 23904267 DOI: 10.1091/Mbc.E13-05-0254 |
0.337 |
|
| 2013 |
Ferguson JL, Chao WC, Lee E, Friedman KL. The anaphase promoting complex contributes to the degradation of the S. cerevisiae telomerase recruitment subunit Est1p. Plos One. 8: e55055. PMID 23372810 DOI: 10.1371/Journal.Pone.0055055 |
0.402 |
|
| 2013 |
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E. The way Wnt works: components and mechanism. Growth Factors (Chur, Switzerland). 31: 1-31. PMID 23256519 DOI: 10.3109/08977194.2012.752737 |
0.503 |
|
| 2012 |
Jodoin JN, Shboul M, Sitaram P, Zein-Sabatto H, Reversade B, Lee E, Lee LA. Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Molecular Biology of the Cell. 23: 4713-24. PMID 23097494 DOI: 10.1091/Mbc.E12-07-0558 |
0.307 |
|
| 2012 |
Sitaram P, Anderson MA, Jodoin JN, Lee E, Lee LA. Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis. Development (Cambridge, England). 139: 2945-54. PMID 22764052 DOI: 10.1242/Dev.077511 |
0.345 |
|
| 2012 |
Hanson AJ, Wallace HA, Freeman TJ, Beauchamp RD, Lee LA, Lee E. XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Molecular Cell. 45: 619-28. PMID 22304967 DOI: 10.1016/J.Molcel.2011.12.032 |
0.53 |
|
| 2012 |
Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E. Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs. Bioorganic & Medicinal Chemistry. 20: 1869-77. PMID 22261025 DOI: 10.1016/J.Bmc.2011.12.044 |
0.419 |
|
| 2011 |
Ni TT, Rellinger EJ, Mukherjee A, Xie S, Stephens L, Thorne CA, Kim K, Hu J, Lee E, Marnett L, Hatzopoulos AK, Zhong TP. Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chemistry & Biology. 18: 1658-68. PMID 22195568 DOI: 10.1016/J.Chembiol.2011.09.015 |
0.422 |
|
| 2011 |
Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, ... ... Lee E, et al. A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts. Journal of Biomolecular Screening. 16: 995-1006. PMID 21859680 DOI: 10.1177/1087057111416657 |
0.774 |
|
| 2011 |
Singh S, Wang Z, Liang Fei D, Black KE, Goetz JA, Tokhunts R, Giambelli C, Rodriguez-Blanco J, Long J, Lee E, Briegel KJ, Bejarano PA, Dmitrovsky E, Capobianco AJ, Robbins DJ. Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity. Cancer Research. 71: 4454-63. PMID 21565978 DOI: 10.1158/0008-5472.Can-10-2313 |
0.382 |
|
| 2011 |
Bauer JA, Lehmann BD, Glick G, Cortez D, Lee E, Pietenpol JA. Abstract 951: Loss-of-function screening identifies therapeutic targets for triple negative breast cancer (TNBC) Cancer Research. 71: 951-951. DOI: 10.1158/1538-7445.Am2011-951 |
0.4 |
|
| 2010 |
Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E, Young PP. Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling. Plos One. 5: e15521. PMID 21170416 DOI: 10.1371/Journal.Pone.0015521 |
0.384 |
|
| 2010 |
Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, ... ... Lee E, et al. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nature Chemical Biology. 6: 829-36. PMID 20890287 DOI: 10.1038/Nchembio.453 |
0.79 |
|
| 2010 |
Alfaro MP, Vincent A, Saraswati S, Thorne CA, Hong CC, Lee E, Young PP. sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair. The Journal of Biological Chemistry. 285: 35645-53. PMID 20826809 DOI: 10.1074/Jbc.M110.135335 |
0.379 |
|
| 2010 |
Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E. Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Science Signaling. 3: ra37. PMID 20460648 DOI: 10.1126/Scisignal.2000647 |
0.757 |
|
| 2010 |
Speirs CK, Jernigan KK, Kim SH, Cha YI, Lin F, Sepich DS, DuBois RN, Lee E, Solnica-Krezel L. Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Development (Cambridge, England). 137: 1327-37. PMID 20332150 DOI: 10.1242/Dev.045971 |
0.44 |
|
| 2009 |
Anderson MA, Jodoin JN, Lee E, Hales KG, Hays TS, Lee LA. Asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis. Molecular Biology of the Cell. 20: 2709-21. PMID 19357193 DOI: 10.1091/Mbc.E08-12-1165 |
0.312 |
|
| 2009 |
Barton CE, Tahinci E, Barbieri CE, Johnson KN, Hanson AJ, Jernigan KK, Chen TW, Lee E, Pietenpol JA. DeltaNp63 antagonizes p53 to regulate mesoderm induction in Xenopus laevis. Developmental Biology. 329: 130-9. PMID 19272371 DOI: 10.1016/J.Ydbio.2009.02.036 |
0.323 |
|
| 2009 |
Merkle JA, Rickmyre JL, Garg A, Loggins EB, Jodoin JN, Lee E, Wu LP, Lee LA. no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila. Development (Cambridge, England). 136: 449-59. PMID 19141674 DOI: 10.1242/Dev.027599 |
0.308 |
|
| 2009 |
Smith JJ, Freeman TJ, Deane NG, Zi J, Poon S, Chen S, Kis C, Lee E, Dhawan P, Washington MK, Shyr Y, Beauchamp RD. Abstract B49: Smad4 suppresses Wnt signaling through downregulation of β-catenin Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-B49 |
0.414 |
|
| 2008 |
Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E. LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin. Proceedings of the National Academy of Sciences of the United States of America. 105: 8032-7. PMID 18509060 DOI: 10.1073/Pnas.0803025105 |
0.788 |
|
| 2008 |
Cselenyi CS, Lee E. Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen. Science Signaling. 1: pe10. PMID 18314504 DOI: 10.1126/Stke.18Pe10 |
0.798 |
|
| 2008 |
Moore AC, Amann JM, Williams CS, Tahinci E, Farmer TE, Martinez JA, Yang G, Luce KS, Lee E, Hiebert SW. Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription. Molecular and Cellular Biology. 28: 977-87. PMID 18039847 DOI: 10.1128/Mcb.01242-07 |
0.422 |
|
| 2007 |
Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E. Lrp6 is required for convergent extension during Xenopus gastrulation. Development (Cambridge, England). 134: 4095-106. PMID 17965054 DOI: 10.1242/Dev.010272 |
0.569 |
|
| 2007 |
Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, Waddell S, Lee LA. The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. Journal of Cell Science. 120: 3565-77. PMID 17895362 DOI: 10.1242/Jcs.016626 |
0.319 |
|
| 2005 |
Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW, Orr-Weaver TL. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Developmental Cell. 8: 435-42. PMID 15737938 DOI: 10.1016/J.Devcel.2004.12.008 |
0.355 |
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| 2004 |
Tahinci E, Lee E. The interface between cell and developmental biology. Current Opinion in Genetics & Development. 14: 361-6. PMID 15261651 DOI: 10.1016/J.Gde.2004.06.013 |
0.393 |
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| 2004 |
Ivanovska I, Lee E, Kwan KM, Fenger DD, Orr-Weaver TL. The Drosophila MOS ortholog is not essential for meiosis. Current Biology : Cb. 14: 75-80. PMID 14711418 DOI: 10.1016/J.Cub.2003.12.031 |
0.36 |
|
| 2004 |
Moore A, Tahinci E, Lee E, Hiebert S. RUNX1-ETO Stimulates Wnt Signaling by Inhibiting the Function of ETO Family Member Proteins. Blood. 104: 2554-2554. DOI: 10.1182/Blood.V104.11.2554.2554 |
0.477 |
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| 2003 |
Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. Plos Biology. 1: E10. PMID 14551908 DOI: 10.1371/Journal.Pbio.0000010 |
0.563 |
|
| 2001 |
Pfleger CM, Lee E, Kirschner MW. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes & Development. 15: 2396-407. PMID 11562349 DOI: 10.1101/Gad.918201 |
0.323 |
|
| 2001 |
Lee E, Salic A, Kirschner MW. Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. The Journal of Cell Biology. 154: 983-93. PMID 11524435 DOI: 10.1083/Jcb.200102074 |
0.498 |
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| 2001 |
Pfleger CM, Salic A, Lee E, Kirschner MW. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes & Development. 15: 1759-64. PMID 11459825 DOI: 10.1101/Gad.897901 |
0.402 |
|
| 2000 |
Salic A, Lee E, Mayer L, Kirschner MW. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Molecular Cell. 5: 523-32. PMID 10882137 DOI: 10.1016/S1097-2765(00)80446-3 |
0.496 |
|
| 1996 |
Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR. Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis. Structure (London, England : 1993). 4: 1277-90. PMID 8939752 DOI: 10.1016/S0969-2126(96)00136-0 |
0.574 |
|
| 1996 |
Sprang SR, Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG. The crystallographic structure of a G protein heterotrimer Acta Crystallographica Section a Foundations of Crystallography. 52: C175-C175. DOI: 10.1107/S0108767396092276 |
0.46 |
|
| 1995 |
Wall MA, Coleman DE, Lee E, Iñiguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR. The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell. 83: 1047-58. PMID 8521505 DOI: 10.1016/0092-8674(95)90220-1 |
0.599 |
|
| 1995 |
Mixon MB, Lee E, Coleman DE, Berghuis AM, Gilman AG, Sprang SR. Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science (New York, N.Y.). 270: 954-60. PMID 7481799 DOI: 10.1126/Science.270.5238.954 |
0.574 |
|
| 1994 |
Coleman DE, Lee E, Mixon MB, Linder ME, Berghuis AM, Gilman AG, Sprang SR. Crystallization and preliminary crystallographic studies of Gi alpha 1 and mutants of Gi alpha 1 in the GTP and GDP-bound states. Journal of Molecular Biology. 238: 630-4. PMID 8176751 DOI: 10.1006/Jmbi.1994.1320 |
0.628 |
|
| 1994 |
Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR. Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science (New York, N.Y.). 265: 1405-12. PMID 8073283 DOI: 10.1126/Science.8073283 |
0.658 |
|
| 1994 |
Kleuss C, Raw AS, Lee E, Sprang SR, Gilman AG. Mechanism of GTP hydrolysis by G-protein alpha subunits. Proceedings of the National Academy of Sciences of the United States of America. 91: 9828-31. PMID 7937899 DOI: 10.1073/Pnas.91.21.9828 |
0.579 |
|
| 1994 |
Lee E, Linder ME, Gilman AG. [12] Expression of G-protein α subunits in Escherichia coli Methods in Enzymology. 237: 146-154. PMID 7934993 DOI: 10.1016/S0076-6879(94)37059-1 |
0.651 |
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