Vincent Giguere - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
Area:
Molecular Biology

149 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tripathi M, Gauthier K, Sandireddy R, Zhou J, Gupta P, Sakthivel S, Jiemin N, Arul K, Tikno K, Park SH, Wang L, Ho L, Giguere V, Ghosh S, McDonnell DP, et al. Estrogen receptor-related receptor (Esrra) induces ribosomal protein Rplp1-mediated adaptive hepatic translation during prolonged starvation. Biorxiv : the Preprint Server For Biology. PMID 38260502 DOI: 10.1101/2024.01.09.574937  0.301
2023 Chen Y, Han L, Dufour CR, Alfonso A, Giguere V. Canonical and nuclear mTOR specify distinct transcriptional programs in androgen-dependent prostate cancer cells. Molecular Cancer Research : McR. PMID 37889103 DOI: 10.1158/1541-7786.MCR-23-0087  0.301
2022 Rahbani JF, Scholtes C, Lagarde DM, Hussain MF, Roesler A, Dykstra CB, Bunk J, Samborska B, O'Brien SL, Tripp E, Pacis A, Angueira AR, Johansen OS, Cinkornpumin J, Hossain I, et al. ADRA1A-Gα signalling potentiates adipocyte thermogenesis through CKB and TNAP. Nature Metabolism. PMID 36344764 DOI: 10.1038/s42255-022-00667-w  0.304
2022 Giguere V, Evans RM. Chronicle of a discovery: the retinoic acid receptor. Journal of Molecular Endocrinology. PMID 35900848 DOI: 10.1530/JME-22-0117  0.336
2022 Scholtes C, Giguère V. Transcriptional control of energy metabolism by nuclear receptors. Nature Reviews. Molecular Cell Biology. PMID 35577989 DOI: 10.1038/s41580-022-00486-7  0.384
2020 Vernier M, McGuirk S, Dufour CR, Wan L, Audet-Walsh E, St-Pierre J, Giguère V. Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4. Oncogene. PMID 32855526 DOI: 10.1038/S41388-020-01438-1  0.382
2020 Giguère V. DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer. Trends in Cancer. 6: 337-347. PMID 32209447 DOI: 10.1016/J.Trecan.2020.01.015  0.349
2020 Vernier M, Dufour CR, McGuirk S, Scholtes C, Li X, Bourmeau G, Kuasne H, Park M, St-Pierre J, Audet-Walsh E, Giguère V. Estrogen-related receptors are targetable ROS sensors. Genes & Development. PMID 32079653 DOI: 10.1101/Gad.330746.119  0.363
2019 Smith HW, Hirukawa A, Sanguin-Gendreau V, Nandi I, Dufour CR, Zuo D, Tandoc K, Leibovitch M, Singh S, Rennhack JP, Swiatnicki M, Lavoie C, Papavasiliou V, Temps C, Carragher NO, et al. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Nature Communications. 10: 2901. PMID 31263101 DOI: 10.1038/S41467-019-10681-4  0.345
2019 Xia H, Dufour CR, Giguère V. ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease. Frontiers in Endocrinology. 10: 206. PMID 31024446 DOI: 10.3389/Fendo.2019.00206  0.454
2019 Ghanbari F, Hebert-Losier A, Barry J, Poirier D, Giguere V, Mader S, Philip A. Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine. The Journal of Steroid Biochemistry and Molecular Biology. PMID 30954508 DOI: 10.1016/J.Jsbmb.2019.04.001  0.463
2019 Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, et al. Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30926667 DOI: 10.1073/Pnas.1816023116  0.339
2019 Likhite N, Yadav V, Milliman EJ, Sopariwala DH, Lorca S, Narayana NP, Sheth M, Reineke EL, Giguère V, Narkar V. Loss of estrogen-related receptor alpha facilitates angiogenesis in endothelial cells. Molecular and Cellular Biology. PMID 30602497 DOI: 10.1128/Mcb.00411-18  0.382
2019 Shatnawi AA, Giguere V. Abstract 5253: Regulation of estrogen related receptor α by ING4 and its potential role in breast cancer pathogenesis Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-5253  0.398
2018 Hirukawa A, Smith HW, Zuo D, Dufour CR, Savage P, Bertos N, Johnson RM, Bui T, Bourque G, Basik M, Giguère V, Park M, Muller WJ. Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program. Nature Communications. 9: 2547. PMID 29959321 DOI: 10.1038/S41467-018-04864-8  0.31
2018 Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, et al. Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. Science Signaling. 11. PMID 29945885 DOI: 10.1126/Scisignal.Aam5855  0.401
2018 Audet-Walsh E, Vernier M, Yee T, Laflamme CE, Li S, Chen Y, Giguere V. SREBF1 Activity is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer. Molecular Cancer Research : McR. PMID 29784665 DOI: 10.1158/1541-7786.Mcr-17-0410  0.429
2018 B'chir W, Dufour CR, Ouellet C, Yan M, Tam IS, Andrzejewski S, Xia H, Nabata K, St-Pierre J, Giguère V. Divergent Role of Estrogen-Related Receptor α in Lipid- and Fasting-induced Hepatic Steatosis in Mice. Endocrinology. PMID 29635284 DOI: 10.1210/En.2018-00115  0.363
2018 Giguère V. Canonical signaling and nuclear activity of mTOR: a teamwork effort to regulate metabolism and cell growth. The Febs Journal. PMID 29337437 DOI: 10.1111/Febs.14384  0.383
2018 Hirukawa A, Smith H, Zou D, Savage P, Johnson R, Bourque G, Giguere V, Basik M, Dufour C, Park M, Muller W. Abstract B46: Targeting EZH2 reactivates a breast cancer subtype-specific antimetastatic transcriptional program Molecular Cancer Research. 16. DOI: 10.1158/1557-3125.Advbc17-B46  0.303
2017 Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Giguère V, Jo EK. ESRRA (estrogen related receptor, alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Autophagy. 0. PMID 28841353 DOI: 10.1080/15548627.2017.1339001  0.433
2017 Audet-Walsh É, Dufour CR, Yee T, Zouanat FZ, Yan M, Kalloghlian G, Vernier M, Caron M, Bourque G, Scarlata E, Hamel L, Brimo F, Aprikian AG, Lapointe J, Chevalier S, et al. Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer. Genes & Development. PMID 28724614 DOI: 10.1101/Gad.299958.117  0.396
2017 Bae S, Lee MJ, Mun SH, Giannopoulou EG, Yong-Gonzalez V, Cross JR, Murata K, Giguère V, van der Meulen M, Park-Min KH. MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα. The Journal of Clinical Investigation. PMID 28530645 DOI: 10.1172/Jci89935  0.375
2017 Audet-Walsh É, Yee T, Tam IS, Giguère V. Inverse regulation of DHT synthesis enzymes 5α Reductase Types 1 and 2 by the androgen receptor in prostate cancer. Endocrinology. PMID 28324044 DOI: 10.1210/En.2016-1926  0.377
2016 Audet-Walsh E, Yee T, McGuirk S, Vernier M, Ouellet C, St-Pierre J, Giguere V. Androgen-dependent repression of ERRγ reprograms metabolism in prostate cancer. Cancer Research. PMID 27821488 DOI: 10.1158/0008-5472.Can-16-1204  0.382
2016 Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, et al. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791185 DOI: 10.1073/Pnas.1615540113  0.393
2016 Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V. ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nature Communications. 7: 12156. PMID 27402251 DOI: 10.1038/Ncomms12156  0.346
2016 Yan M, Audet-Walsh É, Manteghi S, Rosa Dufour C, Walker B, Baba M, St-Pierre J, Giguère V, Pause A. Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα. Genes & Development. 30: 1034-46. PMID 27151976 DOI: 10.1101/Gad.281410.116  0.392
2016 Audet-Walsh É, Papadopoli DJ, Gravel SP, Yee T, Bridon G, Caron M, Bourque G, Giguère V, St-Pierre J. The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell Reports. PMID 26804918 DOI: 10.1016/J.Celrep.2015.12.086  0.378
2016 Tam IS, Giguère V. There and back again: The journey of the estrogen-related receptors in the cancer realm. The Journal of Steroid Biochemistry and Molecular Biology. 157: 13-9. PMID 26151739 DOI: 10.1016/J.Jsbmb.2015.06.009  0.459
2016 Vernier M, Audet-Walsh E, Tam I, Deblois G, Giguère V. Abstract 4445: The estrogen related receptor alpha regulates one carbon metabolism and DNA methylation Cancer Research. 76: 4445-4445. DOI: 10.1158/1538-7445.Am2016-4445  0.392
2015 Yuk JM, Kim TS, Kim SY, Lee HM, Han J, Dufour CR, Kim JK, Jin HS, Yang CS, Park KS, Lee CH, Kim JM, Kweon GR, Choi HS, Vanacker JM, et al. Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation. Immunity. 43: 80-91. PMID 26200012 DOI: 10.1016/J.Immuni.2015.07.003  0.425
2015 Giguère V. Editorial: What's in a Name, or the Impact of Misnomers in Endocrine Research. Molecular Endocrinology (Baltimore, Md.). 29: 789-90. PMID 26030126 DOI: 10.1210/Me.2015-1119  0.409
2015 Wang T, McDonald C, Petrenko NB, Leblanc M, Wang T, Giguere V, Evans RM, Patel VV, Pei L. Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function. Molecular and Cellular Biology. 35: 1281-98. PMID 25624346 DOI: 10.1128/Mcb.01156-14  0.384
2015 Audet-Walsh É, Giguére V. The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases. Acta Pharmacologica Sinica. 36: 51-61. PMID 25500872 DOI: 10.1038/Aps.2014.121  0.418
2014 Liu X, Giguère V. Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transitions. Nuclear Receptor Signaling. 12: e004. PMID 25422594 DOI: 10.1621/Nrs.12004  0.34
2014 Perry MC, Dufour CR, Tam IS, B'chir W, Giguère V. Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness. Molecular Endocrinology (Baltimore, Md.). 28: 2060-71. PMID 25361393 DOI: 10.1210/Me.2014-1281  0.341
2014 Sailland J, Tribollet V, Forcet C, Billon C, Barenton B, Carnesecchi J, Bachmann A, Gauthier KC, Yu S, Giguère V, Chan FL, Vanacker JM. Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration. Proceedings of the National Academy of Sciences of the United States of America. 111: 15108-13. PMID 25288732 DOI: 10.1073/Pnas.1402094111  0.435
2014 Perry MC, Dufour CR, Eichner LJ, Tsang DW, Deblois G, Muller WJ, Giguère V. ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction. Molecular and Cellular Biology. 34: 4232-43. PMID 25246633 DOI: 10.1128/Mcb.00895-14  0.327
2014 Giguère V. Estrogen receptor mutations in breast cancer-an anticipated "rediscovery?". Molecular Endocrinology (Baltimore, Md.). 28: 427-8. PMID 24684382 DOI: 10.1210/Me.2014-1071  0.38
2014 Labbé DP, Nowak DG, Deblois G, Lessard L, Giguère V, Trotman LC, Tremblay ML. Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors. Molecular Cancer Research : McR. 12: 184-9. PMID 24379448 DOI: 10.1158/1541-7786.Mcr-13-0477  0.328
2014 Shatnawi A, Norris JD, Chaveroux C, Jasper JS, Sherk AB, McDonnell DP, Giguère V. ELF3 is a repressor of androgen receptor action in prostate cancer cells. Oncogene. 33: 862-71. PMID 23435425 DOI: 10.1038/Onc.2013.15  0.426
2014 Audet-Walsh É, Papadopoli D, St-Pierre J, Giguère V. Abstract 2436: Regulation of breast cancer cell metabolism by the AMPK/ERR/PGC pathway Cancer Research. 74: 2436-2436. DOI: 10.1158/1538-7445.Am2014-2436  0.431
2013 McGuirk S, Gravel SP, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J. PGC-1α supports glutamine metabolism in breast cancer. Cancer & Metabolism. 1: 22. PMID 24304688 DOI: 10.1186/2049-3002-1-22  0.314
2013 Hong EJ, Levasseur MP, Dufour CR, Perry MC, Giguère V. Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances. Proceedings of the National Academy of Sciences of the United States of America. 110: 17975-80. PMID 24127579 DOI: 10.1073/Pnas.1315319110  0.415
2013 Deblois G, St-Pierre J, Giguère V. The PGC-1/ERR signaling axis in cancer Oncogene. 32: 3483-3490. PMID 23208510 DOI: 10.1038/Onc.2012.529  0.421
2013 Deblois G, Giguère V. Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond. Nature Reviews. Cancer. 13: 27-36. PMID 23192231 DOI: 10.1038/Nrc3396  0.417
2012 Lessard L, Labbé DP, Deblois G, Bégin LR, Hardy S, Mes-Masson AM, Saad F, Trotman LC, Giguère V, Tremblay ML. PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Cancer Research. 72: 1529-37. PMID 22282656 DOI: 10.1158/0008-5472.Can-11-2602  0.369
2012 Deblois G, Giguère V. Cancer: Reprogramming clinical outcome. Nature. 481: 275-6. PMID 22258604 DOI: 10.1038/481275A  0.4
2012 Giguère V. Application of the firefly luciferase reporter gene. Methods in Molecular Biology (Clifton, N.J.). 7: 237-41. PMID 21416359 DOI: 10.1385/0-89603-178-0:237  0.318
2011 Giguère V, Dufour CR, Eichner LJ, Deblois G, Cermakian N. Estrogen-Related Receptor α, the Molecular Clock, and Transcriptional Control of Metabolic Outputs Cold Spring Harbor Symposia On Quantitative Biology. 76: 57-61. PMID 22179984 DOI: 10.1101/Sqb.2011.76.011031  0.419
2011 Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, et al. Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 108: 18348-53. PMID 22042850 DOI: 10.1073/Pnas.1108856108  0.373
2011 Dufour CR, Levasseur MP, Pham NH, Eichner LJ, Wilson BJ, Charest-Marcotte A, Duguay D, Poirier-Héon JF, Cermakian N, Giguère V. Genomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputs. Plos Genetics. 7: e1002143. PMID 21731503 DOI: 10.1371/Journal.Pgen.1002143  0.415
2011 Marquis JF, Kapoustina O, Langlais D, Ruddy R, Dufour CR, Kim BH, MacMicking JD, Giguère V, Gros P. Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis. Plos Genetics. 7: e1002097. PMID 21731497 DOI: 10.1371/Journal.Pgen.1002097  0.353
2011 Eichner LJ, Giguère V. Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks. Mitochondrion. 11: 544-52. PMID 21497207 DOI: 10.1016/J.Mito.2011.03.121  0.415
2011 Deblois G, Giguère V. Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease. Biochimica Et Biophysica Acta. 1812: 1032-40. PMID 21172432 DOI: 10.1016/J.Bbadis.2010.12.009  0.48
2010 Deblois G, Chahrour G, Perry MC, Sylvain-Drolet G, Muller WJ, Giguère V. Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis. Cancer Research. 70: 10277-87. PMID 20961995 DOI: 10.1158/0008-5472.Can-10-2840  0.412
2010 Eichner LJ, Perry MC, Dufour CR, Bertos N, Park M, St-Pierre J, Giguère V. miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway. Cell Metabolism. 12: 352-61. PMID 20889127 DOI: 10.1016/J.Cmet.2010.09.002  0.314
2010 Wilson BJ, Tremblay AM, Deblois G, Sylvain-Drolet G, Giguère V. An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha. Molecular Endocrinology (Baltimore, Md.). 24: 1349-58. PMID 20484414 DOI: 10.1210/Me.2009-0441  0.459
2010 Charest-Marcotte A, Dufour CR, Wilson BJ, Tremblay AM, Eichner LJ, Arlow DH, Mootha VK, Giguère V. The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions. Genes & Development. 24: 537-42. PMID 20194433 DOI: 10.1101/Gad.1871610  0.366
2010 Tremblay AM, Dufour CR, Ghahremani M, Reudelhuber TL, Giguère V. Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway. Molecular Endocrinology (Baltimore, Md.). 24: 22-32. PMID 19901197 DOI: 10.1210/Me.2009-0254  0.389
2010 Giguère V, Eichner LJ, Deblois G. 4 Control of cancer cell metabolism by nuclear receptor-based transcriptional pathways Ejc Supplements. 8: 1-2. DOI: 10.1016/S1359-6349(10)70813-2  0.436
2009 Teyssier C, Gallet M, Rabier B, Monfoulet L, Dine J, Macari C, Espallergues J, Horard B, Giguère V, Cohen-Solal M, Chassande O, Vanacker JM. Absence of ERRalpha in female mice confers resistance to bone loss induced by age or estrogen-deficiency. Plos One. 4: e7942. PMID 19936213 DOI: 10.1371/Journal.Pone.0007942  0.326
2008 Giguère V. Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocrine Reviews. 29: 677-96. PMID 18664618 DOI: 10.1210/Er.2008-0017  0.494
2008 Wilson BJ, Giguère V. Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway. Molecular Cancer. 7: 49. PMID 18533032 DOI: 10.1186/1476-4598-7-49  0.459
2008 Deblois G, Giguère V. Nuclear receptor location analyses in mammalian genomes: from gene regulation to regulatory networks. Molecular Endocrinology (Baltimore, Md.). 22: 1999-2011. PMID 18292239 DOI: 10.1210/Me.2007-0546  0.469
2008 Tremblay AM, Wilson BJ, Yang XJ, Giguère V. Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif. Molecular Endocrinology (Baltimore, Md.). 22: 570-84. PMID 18063693 DOI: 10.1210/Me.2007-0357  0.431
2007 Tremblay AM, Giguère V. The NR3B subgroup: an ovERRview. Nuclear Receptor Signaling. 5: e009. PMID 18174917 DOI: 10.1621/Nrs.05009  0.44
2007 Huss JM, Imahashi K, Dufour CR, Weinheimer CJ, Courtois M, Kovacs A, Giguère V, Murphy E, Kelly DP. The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metabolism. 6: 25-37. PMID 17618854 DOI: 10.1016/J.Cmet.2007.06.005  0.327
2007 Villena JA, Hock MB, Chang WY, Barcas JE, Giguère V, Kralli A. Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 1418-23. PMID 17229846 DOI: 10.1073/Pnas.0607696104  0.44
2006 Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. International union of pharmacology. LXVI. Orphan nuclear receptors Pharmacological Reviews. 58: 798-836. PMID 17132856 DOI: 10.1124/Pr.58.4.10  0.455
2006 Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacological Reviews. 58: 782-97. PMID 17132855 DOI: 10.1124/Pr.58.4.9  0.44
2006 Laganière J, Giguère V. [Decoding the mode of action of the estrogen receptor through functional genomics]. Bulletin Du Cancer. 93: 883-7. PMID 16980231  0.391
2006 Liu D, Hinshelwood MM, Giguère V, Mendelson CR. Estrogen related receptor-alpha enhances surfactant protein-A gene expression in fetal lung type II cells. Endocrinology. 147: 5187-95. PMID 16916954 DOI: 10.1210/En.2006-0664  0.376
2006 Blanchette M, Bataille AR, Chen X, Poitras C, Laganière J, Lefèbvre C, Deblois G, Giguère V, Ferretti V, Bergeron D, Coulombe B, Robert F. Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression. Genome Research. 16: 656-68. PMID 16606704 DOI: 10.1101/Gr.4866006  0.339
2006 Grégoire S, Tremblay AM, Xiao L, Yang Q, Ma K, Nie J, Mao Z, Wu Z, Giguère V, Yang XJ. Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. The Journal of Biological Chemistry. 281: 4423-33. PMID 16356933 DOI: 10.1074/Jbc.M509471200  0.325
2006 Herzog B, Cardenas J, Hall RK, Villena JA, Budge PJ, Giguère V, Granner DK, Kralli A. Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription. The Journal of Biological Chemistry. 281: 99-106. PMID 16267049 DOI: 10.1074/Jbc.M509276200  0.41
2006 Barry JB, Laganière J, Giguère V. A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters. Molecular Endocrinology (Baltimore, Md.). 20: 302-10. PMID 16150865 DOI: 10.1210/Me.2005-0313  0.422
2005 Wende AR, Huss JM, Schaeffer PJ, Giguère V, Kelly DP. PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Molecular and Cellular Biology. 25: 10684-94. PMID 16314495 DOI: 10.1128/Mcb.25.24.10684-10694.2005  0.353
2005 Guillaumond F, Dardente H, Giguère V, Cermakian N. Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. Journal of Biological Rhythms. 20: 391-403. PMID 16267379 DOI: 10.1177/0748730405277232  0.422
2005 Laganière J, Deblois G, Lefebvre C, Bataille AR, Robert F, Giguère V. From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proceedings of the National Academy of Sciences of the United States of America. 102: 11651-6. PMID 16087863 DOI: 10.1073/Pnas.0505575102  0.497
2005 Barry JB, Giguère V. Epidermal growth factor-induced signaling in breast cancer cells results in selective target gene activation by orphan nuclear receptor estrogen-related receptor alpha. Cancer Research. 65: 6120-9. PMID 16024613 DOI: 10.1158/0008-5472.Can-05-0922  0.49
2005 Seely J, Amigh KS, Suzuki T, Mayhew B, Sasano H, Giguere V, Laganière J, Carr BR, Rainey WE. Transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha. Endocrinology. 146: 3605-13. PMID 15878968 DOI: 10.1210/En.2004-1619  0.448
2005 Laganière J, Deblois G, Giguère V. Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 19: 1584-92. PMID 15831516 DOI: 10.1210/Me.2005-0040  0.491
2005 Snyder JM, Jenkins-Moore M, Jackson SK, Goss KL, Dai HH, Bangsund PJ, Giguere V, McGowan SE. Alveolarization in retinoic acid receptor-beta-deficient mice. Pediatric Research. 57: 384-91. PMID 15635054 DOI: 10.1203/01.Pdr.0000151315.81106.D3  0.334
2004 Carrier JC, Deblois G, Champigny C, Levy E, Giguère V. Estrogen-related receptor alpha (ERRalpha) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestine. The Journal of Biological Chemistry. 279: 52052-8. PMID 15466464 DOI: 10.1074/Jbc.M410337200  0.418
2004 Huss JM, Torra IP, Staels B, Giguère V, Kelly DP. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Molecular and Cellular Biology. 24: 9079-91. PMID 15456881 DOI: 10.1128/Mcb.24.20.9079-9091.2004  0.445
2004 Dzhagalov I, Giguère V, He YW. Lymphocyte development and function in the absence of retinoic acid-related orphan receptor alpha. Journal of Immunology (Baltimore, Md. : 1950). 173: 2952-9. PMID 15322153 DOI: 10.4049/Jimmunol.173.5.2952  0.342
2003 Laganière J, Deblois G, Giguère V. Nuclear receptor target gene discovery using high-throughput chromatin immunoprecipitation. Methods in Enzymology. 364: 339-50. PMID 14631854 DOI: 10.1016/S0076-6879(03)64019-X  0.49
2003 Moraitis AN, Giguère V. The co-repressor hairless protects RORalpha orphan nuclear receptor from proteasome-mediated degradation. The Journal of Biological Chemistry. 278: 52511-8. PMID 14570920 DOI: 10.1074/Jbc.M308152200  0.739
2003 Deblois G, Giguère V. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. The Journal of Steroid Biochemistry and Molecular Biology. 85: 123-31. PMID 12943696 DOI: 10.1016/S0960-0760(03)00225-5  0.458
2003 Bai Y, Giguére V. Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells. Molecular Endocrinology (Baltimore, Md.). 17: 589-99. PMID 12554772 DOI: 10.1210/Me.2002-0351  0.406
2002 Tremblay GB, Giguère V. Coregulators of estrogen receptor action. Critical Reviews in Eukaryotic Gene Expression. 12: 1-22. PMID 12433063 DOI: 10.1615/Critreveukaryotgeneexpr.V12.I1.10  0.487
2002 Giguère V. To ERR in the estrogen pathway. Trends in Endocrinology and Metabolism: Tem. 13: 220-5. PMID 12185669 DOI: 10.1016/S1043-2760(02)00592-1  0.438
2001 Tremblay GB, Bergeron D, Giguere V. 4-Hydroxytamoxifen Is an Isoform-Specific Inhibitor of Orphan Estrogen-Receptor-Related (ERR) Nuclear Receptors β and γ. Endocrinology. 142: 4572-4575. PMID 28201271 DOI: 10.1210/Endo.142.10.8528  0.501
2001 Labrie F, Labrie C, Bélanger A, Simard J, Giguère V, Tremblay A, Tremblay G. EM-652 (SCH57068), a pure SERM having complete antiestrogenic activity in the mammary gland and endometrium. The Journal of Steroid Biochemistry and Molecular Biology. 79: 213-225. PMID 11850228 DOI: 10.1016/S0960-0760(01)00139-X  0.347
2001 Tremblay A, Giguère V. Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor β Journal of Steroid Biochemistry and Molecular Biology. 77: 19-27. PMID 11358671 DOI: 10.1016/S0960-0760(01)00031-0  0.497
2001 Labrie F, Labrie C, Bélanger A, Giguere V, Simard J, Mérand Y, Gauthier S, Luu-The V, Candas B, Martel C, Luo S. Pure selective estrogen receptor modulators, new molecules having absolute cell specificity ranging from pure antiestrogenic to complete estrogen-like activities. Advances in Protein Chemistry. 56: 293-368. PMID 11329857 DOI: 10.1016/S0065-3233(01)56009-X  0.426
2001 Tremblay GB, Kunath T, Bergeron D, Lapointe L, Champigny C, Bader JA, Rossant J, Giguère V. Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. Genes & Development. 15: 833-8. PMID 11297507 DOI: 10.1101/Gad.873401  0.361
2001 Sauvé F, McBroom LD, Gallant J, Moraitis AN, Labrie F, Giguère V. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. Molecular and Cellular Biology. 21: 343-53. PMID 11113208 DOI: 10.1128/Mcb.21.1.343-353.2001  0.724
2000 Bois-Joyeux B, Chauvet C, Nacer-Chérif H, Bergeret W, Mazure N, Giguère V, Laudet V, Danan J. Modulation of the Far-Upstream Enhancer of the Rat α-Fetoprotein Gene by Members of the RORα, Rev-erbα, and Rev-erbβ Groups of Monomeric Orphan Nuclear Receptors Dna and Cell Biology. 19: 589-599. PMID 11058961 DOI: 10.1089/104454900750019344  0.386
1999 Sladek R, Giguère V. Orphan Nuclear Receptors: An Emerging Family of Metabolic Regulators Advances in Pharmacology (San Diego). 47: 23-87. PMID 10582084 DOI: 10.1016/S1054-3589(08)60109-X  0.515
1999 Giguère V. Orphan nuclear receptors: from gene to function. Endocrine Reviews. 20: 689-725. PMID 10529899 DOI: 10.1210/Edrv.20.5.0378  0.429
1999 Labrie F, Labrie C, Bélanger A, Simard J, Gauthier S, Luu-The V, Mérand Y, Giguere V, Candas B, Luo S, Martel C, Singh SM, Fournier M, Coquet A, Richard V, et al. EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium. The Journal of Steroid Biochemistry and Molecular Biology. 69: 51-84. PMID 10418981 DOI: 10.1016/S0960-0760(99)00065-5  0.422
1999 Folberg A, Nagy Kovács E, Luo J, Giguère V, Featherstone MS. RARβ mediates the response of Hoxd4 and Hoxb4 to exogenous retinoic acid Developmental Dynamics. 215: 96-107. PMID 10373014 DOI: 10.1002/(Sici)1097-0177(199906)215:2<96::Aid-Dvdy2>3.0.Co;2-T  0.342
1999 Tremblay A, Tremblay GB, Labrie F, Giguère V. Ligand-Independent recruitment of SRC-1 to estrogen receptor β through phosphorylation of activation function AF-1 Molecular Cell. 3: 513-519. PMID 10230404 DOI: 10.1016/S1097-2765(00)80479-7  0.445
1999 Auwerx J, Baulieu E, Beato M, Becker-Andre M, Burbach PH, Camerino G, Chambon P, Cooney A, Dejean A, Dreyer C, Evans RM, Gannon F, Giguere V, Gronemeyer H, Gustafsson JA, et al. A unified nomenclature system for the nuclear receptor superfamily Cell. 97: 161-163. PMID 10219237 DOI: 10.1016/S0092-8674(00)80726-6  0.437
1999 Moraitis AN, Giguère V. Transition from monomeric to homodimeric DNA binding by nuclear receptors: identification of RevErbAalpha determinants required for RORalpha homodimer complex formation. Molecular Endocrinology (Baltimore, Md.). 13: 431-9. PMID 10077000 DOI: 10.1210/Mend.13.3.0250  0.711
1999 Tremblay GB, Tremblay A, Labrie F, Giguère V. Dominant activity of activation function 1 (AF-1) and differential stoichiometric requirements for AF-1 and -2 in the estrogen receptor α-β heterodimeric complex Molecular and Cellular Biology. 19: 1919-1927. PMID 10022879 DOI: 10.1128/Mcb.19.3.1919  0.461
1998 Giguère V, Tremblay A, Tremblay GB. Estrogen receptor β: Re-evaluation of estrogen and antiestrogen signaling Steroids. 63: 335-339. PMID 9618797 DOI: 10.1016/S0039-128X(98)00024-5  0.483
1998 Dussault I, Fawcett D, Matthyssen A, Bader J, Giguère V. Orphan nuclear receptor RORα-deficient mice display the cerebellar defects of staggerer Mechanisms of Development. 70: 147-153. PMID 9510031 DOI: 10.1016/S0925-4773(97)00187-1  0.383
1998 Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V. Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene. Genomics. 45: 320-6. PMID 9344655 DOI: 10.1006/Geno.1997.4939  0.351
1997 Luo J, Sladek R, Bader J, Matthyssen A, Rossant J, Giguère V. Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta Nature. 388: 778-782. PMID 9285590 DOI: 10.1038/42022  0.39
1997 Sladek R, Bader J, Giguere V. The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene Molecular and Cellular Biology. 17: 5400-5409. PMID 9271417 DOI: 10.1128/Mcb.17.9.5400  0.402
1997 Lee RY, Luo J, Evans RM, Giguere V, Sucov HM. Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations Circulation Research. 80: 757-764. PMID 9168777 DOI: 10.1161/01.Res.80.6.757  0.368
1997 Dussault I, Giguère V. Differential regulation of the N-myc proto-oncogene by ROR alpha and RVR, two orphan members of the superfamily of nuclear hormone receptors. Molecular and Cellular Biology. 17: 1860-1867. PMID 9121434 DOI: 10.1128/Mcb.17.4.1860  0.377
1997 Tremblay GB, Tremblay A, Copeland NG, Gilbert DJ, Jenkins NA, Labrie F, Giguère V. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Molecular Endocrinology (Baltimore, Md.). 11: 353-65. PMID 9058381 DOI: 10.1210/Mend.11.3.9902  0.375
1996 Medvedev A, Yan Z, Hirose T, Giguère V, Jetten AM. Cloning of a cDNA encoding the murine orphan receptor RZR/RORγ and characterization of its response element Gene. 181: 199-206. PMID 8973331 DOI: 10.1016/S0378-1119(96)00504-5  0.433
1996 Burke L, Downes M, Carozzi A, Giguère V, Muscat GEO. Transcriptional Repression by the Orphan Steroid Receptor RVR/Rev-erbβ Is Dependent on the Signature Motif and Helix 5 in the E Region: Functional Evidence for a Biological Role of RVR in Myogenesis Nucleic Acids Research. 24: 3481-3489. PMID 8836172 DOI: 10.1093/Nar/24.18.3481  0.435
1996 Shago M, Giguére V. Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA. Molecular and Cellular Biology. 16: 4337-4348. PMID 8754834 DOI: 10.1128/Mcb.16.8.4337  0.41
1996 Luo J, Sucov HM, Bader JA, Evans RM, Giguère V. Compound mutants for retinoic acid receptor (RAR) β and RARα1 reveal developmental functions for multiple RARβ isoforms Mechanisms of Development. 55: 33-44. PMID 8734497 DOI: 10.1016/0925-4773(95)00488-2  0.312
1996 Giguère V, Beatty B, Squire J, Copeland NG, Jenkins NA. The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9. Genomics. 28: 596-8. PMID 7490103 DOI: 10.1006/Geno.1995.1197  0.303
1996 Sucov HM, LaMorte V, Luo J, Giguere V, Evans RM. The pharmaco-genetics of congenital cardiac defects in retinoic acid receptor deficient mouse embryos Journal of the American College of Cardiology. 27: 2. DOI: 10.1016/S0735-1097(96)80200-2  0.328
1995 Tini M, Tsui LC, Giguère V. Heterodimeric interaction of the retinoic acid and thyroid hormone receptors in transcriptional regulation on the gamma F-crystallin everted retinoic acid response element. Molecular Endocrinology (Baltimore, Md.). 8: 1494-506. PMID 7877618 DOI: 10.1210/MEND.8.11.7877618  0.304
1995 Tini M, Fraser RA, Giguère V. Functional Interactions between Retinoic Acid Receptor-related Orphan Nuclear Receptor (RORα) and the Retinoic Acid Receptors in the Regulation of the γF-Crystallin Promoter Journal of Biological Chemistry. 270: 20156-20161. PMID 7650034 DOI: 10.1074/Jbc.270.34.20156  0.496
1994 Giguère V. Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling. Endocrine Reviews. 15: 61-79. PMID 8156940 DOI: 10.1210/Edrv-15-1-61  0.377
1994 Predki PF, Zamble D, Sarkar B, Giguère V. Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain Molecular Endocrinology. 8: 31-39. PMID 8152429 DOI: 10.1210/Mend.8.1.8152429  0.4
1994 Norris AW, Cheng L, Giguère V, Rosenberger M, Li E. Measurement of subnanomolar retinoic acid binding affinities for cellular retinoic acid binding proteins by fluorometric titration Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 1209: 10-18. PMID 7947970 DOI: 10.1016/0167-4838(94)90130-9  0.309
1993 Tini M, Otulakowski G, Breitman ML, Tsui LC, Giguère V. An everted repeat mediates retinoic acid induction of the gamma F-crystallin gene: evidence of a direct role for retinoids in lens development. Genes & Development. 7: 295-307. PMID 8436299 DOI: 10.1101/Gad.7.2.295  0.353
1993 Sarkar B, Predki P, Zamble D, Giguère V. Non-zinc finger residues specify retinoic acid and retinoid X receptor heterodimer interfaces Journal of Inorganic Biochemistry. 51: 590. DOI: 10.1016/0162-0134(93)85612-C  0.348
1992 Nadeau JH, Compton JG, Giguère V, Rossant J, Varmuza S. Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse chromosomes 11 and 15. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 3: 202-8. PMID 1377062 DOI: 10.1007/Bf00355720  0.419
1991 Giguère V, Evans RM. Identification of receptors for retinoids as members of the steroid and thyroid hormone receptor family. Methods in Enzymology. 189: 223-32. PMID 1963457 DOI: 10.1016/0076-6879(90)89293-Q  0.476
1991 Rossant J, Zirngibl R, Cado D, Shago M, Giguère V. Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes & Development. 5: 1333-1344. PMID 1907940 DOI: 10.1101/Gad.5.8.1333  0.308
1991 Spanopoulou E, Giguere V, Grosveld F. The functional domains of the murine Thy-1 gene promoter. Molecular and Cellular Biology. 11: 2216-28. PMID 1672442 DOI: 10.1128/Mcb.11.4.2216  0.36
1991 Evans R, Ong E, Segui P, Thompson C, Umesono K, Giguere V. 4981784 Retinoic acid receptor method International Journal of Biochemistry. 23. DOI: 10.1016/0020-711X(91)90258-O  0.366
1990 Giguere V, Lyn S, Yip P, Siu C, Amin S. Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 87: 6233-6237. PMID 2166951 DOI: 10.1073/Pnas.87.16.6233  0.405
1990 Giguère V, Shago M, Zirngibl R, Tate P, Rossant J, Varmuza S. Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo. Molecular and Cellular Biology. 10: 2335-2340. PMID 2157970 DOI: 10.1128/Mcb.10.5.2335  0.387
1990 Giguère V. Structure and function of the nuclear receptor superfamily for steroid, thyroid hormone and retinoic acid. Genetic Engineering. 12: 183-200. PMID 1369275 DOI: 10.1007/978-1-4613-0641-2_10  0.502
1989 Giguere V, Ong ES, Evans RM, Tabin CJ. Spatial and temporal expression of the retinoic acid receptor in the regenerating amphibian limb Nature. 337: 566-569. PMID 2536901 DOI: 10.1038/337566A0  0.407
1988 Giguère V, Yang N, Segui P, Evans RM. Identification of a new class of steroid hormone receptors. Nature. 331: 91-4. PMID 3267207 DOI: 10.1038/331091A0  0.471
1988 Spanopoulou E, Giguere V, Grosveld F. Transcriptional unit of the murine Thy-1 gene: different distribution of transcription initiation sites in brain. Molecular and Cellular Biology. 8: 3847-56. PMID 2906111 DOI: 10.1128/Mcb.8.9.3847  0.319
1988 Umesono K, Giguere V, Glass CK, Rosenfeld MG, Evans RM. Retinoic acid and thyroid hormone induce gene expression through a common responsive element Nature. 336: 262-265. PMID 2848197 DOI: 10.1038/336262A0  0.474
1987 Hollenberg SM, Giguere V, Segui P, Evans RM. Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. Cell. 49: 39-46. PMID 3829127 DOI: 10.1016/0092-8674(87)90753-7  0.446
1987 Weinberger C, Giguere V, Hollenberg S, Rosenfeld MG, Evans RM. Human steroid receptors and erbA proto-oncogene products: members of a new superfamily of enhancer binding proteins. Cold Spring Harbor Symposia On Quantitative Biology. 759-72. PMID 3034496 DOI: 10.1101/Sqb.1986.051.01.089  0.396
1987 Giguere V, Ong ES, Segui P, Evans RM. Identification of a receptor for the morphogen retinoic acid. Nature. 330: 624-629. PMID 2825036 DOI: 10.1038/330624A0  0.475
1986 Giguère V, Hollenberg SM, Rosenfeld MG, Evans RM. Functional domains of the human glucocorticoid receptor. Cell. 46: 645-52. PMID 3742595 DOI: 10.1016/0092-8674(86)90339-9  0.457
1984 Labrie F, Giguere V, Proulx L, Lefevre G. Interactions between CRF, epinephrine, vasopressin and glucocorticoids in the control of acth secretion Journal of Steroid Biochemistry. 20: 153-160. PMID 6323861 DOI: 10.1016/0022-4731(84)90202-4  0.3
1983 Labrie F, Giguère V, Raymond V, Pelletier G, Veilleux R, Cote J, Antakly T. Anterior Pituitary Cells in Culture: A Precise Assay System for Hypothalamic and Peripheral Hormones Advances in Cell Biology. 4: 381-406. DOI: 10.1016/B978-0-12-008304-6.50018-X  0.307
1981 Giguere V, Cote J, Labrie F. Characteristics of the α-Adrenergic Stimulation of Adrenocorticotropin Secretion in Rat Anterior Pituitary Cells Endocrinology. 109: 757-762. PMID 6114856 DOI: 10.1210/Endo-109-3-757  0.319
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