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William Gregory Scott - Publications

Affiliations: 
Chemistry & Biochemistry University of California, Santa Cruz, Santa Cruz, CA, United States 
Area:
RNA structure, catalysis and the origin of life
Website:
http://www.chemistry.ucsc.edu/faculty/singleton.php?&singleton=true&cruz_id=wgscott
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69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lulla V, Wandel MP, Bandyra KJ, Ulferts R, Wu M, Dendooven T, Yang X, Doyle N, Oerum S, Beale R, O'Rourke SM, Randow F, Maier HJ, Scott W, Ding Y, et al. Targeting the conserved stem loop 2 motif in the SARS-CoV-2 genome. Journal of Virology. PMID 33963053 DOI: 10.1128/JVI.00663-21  0.305
2018 Scott WG, Nagai K. Recruiting more proteins to the RNA world. Science (New York, N.Y.). 362: 644-645. PMID 30409874 DOI: 10.1126/Science.Aav4743  0.438
2018 O'Rourke SM, Scott WG. Structural Simplicity and Mechanistic Complexity in the Hammerhead Ribozyme. Progress in Molecular Biology and Translational Science. 159: 177-202. PMID 30340787 DOI: 10.1016/Bs.Pmbts.2018.07.006  0.502
2015 O'Rourke SM, Estell W, Scott WG. Minimal Hammerhead Ribozymes with Uncompromised Catalytic Activity. Journal of Molecular Biology. 427: 2340-7. PMID 25981451 DOI: 10.1016/J.Jmb.2015.05.005  0.793
2015 Fyfe AC, Dunten PW, Martick MM, Scott WG. Structural Variations and Solvent Structure of r(UGGGGU) Quadruplexes Stabilized by Sr(2+) Ions. Journal of Molecular Biology. 427: 2205-19. PMID 25861762 DOI: 10.1016/J.Jmb.2015.03.022  0.812
2015 O'Rourke SM, Estell W, Scott WG. Minimal Hammerhead Ribozymes with Uncompromised Catalytic Activity Journal of Molecular Biology. DOI: 10.1016/j.jmb.2015.05.005  0.756
2015 Fyfe AC, Dunten PW, Martick MM, Scott WG. Structural variations and solvent structure of r(UGGGGU) quadruplexes stabilized by Sr2+ ions Journal of Molecular Biology. 427: 2205-2219. DOI: 10.1016/j.jmb.2015.03.022  0.768
2014 Scott WG, Szöke A, Blaustein J, O'Rourke SM, Robertson MP. RNA catalysis, thermodynamics and the origin of life. Life (Basel, Switzerland). 4: 131-41. PMID 25370189 DOI: 10.3390/Life4020131  0.74
2014 Schultz EP, Vasquez EE, Scott WG. Structural and catalytic effects of an invariant purine substitution in the hammerhead ribozyme: implications for the mechanism of acid-base catalysis. Acta Crystallographica. Section D, Biological Crystallography. 70: 2256-63. PMID 25195740 DOI: 10.1107/S1399004714010608  0.502
2014 Scott WG. Structural biology: How fluorescent RNA gets its glow. Nature. 513: 42-43. PMID 25186897 DOI: 10.1038/513042A  0.449
2013 Scott WG, Horan LH, Martick M. The hammerhead ribozyme: structure, catalysis, and gene regulation. Progress in Molecular Biology and Translational Science. 120: 1-23. PMID 24156940 DOI: 10.1016/B978-0-12-381286-5.00001-9  0.811
2013 Anderson M, Schultz EP, Martick M, Scott WG. Active-site monovalent cations revealed in a 1.55-Ã…-resolution hammerhead ribozyme structure. Journal of Molecular Biology. 425: 3790-8. PMID 23711504 DOI: 10.1016/J.Jmb.2013.05.017  0.775
2012 GiambaÅŸu GM, Lee TS, Scott WG, York DM. Mapping L1 ligase ribozyme conformational switch. Journal of Molecular Biology. 423: 106-22. PMID 22771572 DOI: 10.1016/J.Jmb.2012.06.035  0.47
2012 Scott WG. Challenges and surprises that arise with nucleic acids during model building and refinement. Acta Crystallographica. Section D, Biological Crystallography. 68: 441-5. PMID 22505264 DOI: 10.1107/S0907444912001084  0.353
2010 Ferré-D'Amaré AR, Scott WG. Small self-cleaving ribozymes. Cold Spring Harbor Perspectives in Biology. 2: a003574. PMID 20843979 DOI: 10.1101/Cshperspect.A003574  0.54
2010 Robertson MP, Chi YI, Scott WG. Solving novel RNA structures using only secondary structural fragments. Methods (San Diego, Calif.). 52: 168-72. PMID 20541014 DOI: 10.1016/J.Ymeth.2010.06.011  0.659
2010 Giambasu GM, Lee TS, Sosa CP, Robertson MP, Scott WG, York DM. Identification of dynamical hinge points of the L1 ligase molecular switch. Rna (New York, N.Y.). 16: 769-80. PMID 20167653 DOI: 10.1261/Rna.1897810  0.786
2009 Scott WG, Martick M, Chi YI. Structure and function of regulatory RNA elements: ribozymes that regulate gene expression. Biochimica Et Biophysica Acta. 1789: 634-41. PMID 19781673 DOI: 10.1016/J.Bbagrm.2009.09.006  0.803
2009 Lee TS, Giamba?u GM, Sosa CP, Martick M, Scott WG, York DM. Threshold occupancy and specific cation binding modes in the hammerhead ribozyme active site are required for active conformation. Journal of Molecular Biology. 388: 195-206. PMID 19265710 DOI: 10.1016/J.Jmb.2009.02.054  0.775
2008 Korostelev A, Asahara H, Lancaster L, Laurberg M, Hirschi A, Zhu J, Trakhanov S, Scott WG, Noller HF. Crystal structure of a translation termination complex formed with release factor RF2 Proceedings of the National Academy of Sciences of the United States of America. 105: 19684-19689. PMID 19064930 DOI: 10.1073/Pnas.0810953105  0.375
2008 Daub J, Gardner PP, Tate J, Ramsköld D, Manske M, Scott WG, Weinberg Z, Griffiths-Jones S, Bateman A. The RNA WikiProject: community annotation of RNA families. Rna (New York, N.Y.). 14: 2462-4. PMID 18945806 DOI: 10.1261/Rna.1200508  0.449
2008 Chi YI, Martick M, Lares M, Kim R, Scott WG, Kim SH. Capturing hammerhead ribozyme structures in action by modulating general base catalysis. Plos Biology. 6: e234. PMID 18834200 DOI: 10.1371/Journal.Pbio.0060234  0.824
2008 Koslover DJ, Callaghan AJ, Marcaida MJ, Garman EF, Martick M, Scott WG, Luisi BF. The crystal structure of the Escherichia coli RNase E apoprotein and a mechanism for RNA degradation. Structure (London, England : 1993). 16: 1238-44. PMID 18682225 DOI: 10.1016/J.Str.2008.04.017  0.816
2008 Martick M, Horan LH, Noller HF, Scott WG. A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA Nature. 454: 899-902. PMID 18615019 DOI: 10.1038/Nature07117  0.792
2008 Robertson MP, Scott WG. A general method for phasing novel complex RNA crystal structures without heavy-atom derivatives. Acta Crystallographica. Section D, Biological Crystallography. 738-44. PMID 18566509 DOI: 10.1107/S0907444908011578  0.671
2008 Martick M, Lee TS, York DM, Scott WG. Solvent structure and hammerhead ribozyme catalysis. Chemistry & Biology. 15: 332-42. PMID 18420140 DOI: 10.1016/J.Chembiol.2008.03.010  0.785
2008 Lee TS, Silva López C, Giambasu GM, Martick M, Scott WG, York DM. Role of Mg2+ in hammerhead ribozyme catalysis from molecular simulation. Journal of the American Chemical Society. 130: 3053-64. PMID 18271579 DOI: 10.1021/Ja076529E  0.781
2007 Lee TS, López CS, Martick M, Scott WG, York DM. Insight into the role of Mg in hammerhead ribozyme catalysis from X-ray crystallography and molecular dynamics simulation. Journal of Chemical Theory and Computation. 3: 325-327. PMID 19079784 DOI: 10.1021/Ct6003142  0.766
2007 Robertson MP, Scott WG. Biochemistry: designer enzymes. Nature. 448: 757-8. PMID 17700683 DOI: 10.1038/448757A  0.546
2007 Scott WG. Ribozymes. Current Opinion in Structural Biology. 17: 280-6. PMID 17572081 DOI: 10.1016/j.sbi.2007.05.003  0.32
2007 Scott WG. Morphing the minimal and full-length hammerhead ribozymes: implications for the cleavage mechanism. Biological Chemistry. 388: 727-35. PMID 17570825 DOI: 10.1515/Bc.2007.087  0.556
2007 Robertson MP, Scott WG. The structural basis of ribozyme-catalyzed RNA assembly. Science (New York, N.Y.). 315: 1549-53. PMID 17363667 DOI: 10.1126/Science.1136231  0.728
2006 Martick M, Scott WG. Tertiary contacts distant from the active site prime a ribozyme for catalysis. Cell. 126: 309-20. PMID 16859740 DOI: 10.1016/J.Cell.2006.06.036  0.798
2005 Callaghan AJ, Marcaida MJ, Stead JA, McDowall KJ, Scott WG, Luisi BF. Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover. Nature. 437: 1187-91. PMID 16237448 DOI: 10.1038/Nature04084  0.53
2005 Robertson MP, Igel H, Baertsch R, Haussler D, Ares M, Scott WG. The structure of a rigorously conserved RNA element within the SARS virus genome. Plos Biology. 3: e5. PMID 15630477 DOI: 10.1371/Journal.Pbio.0030005  0.689
2005 Callaghan AJ, Marcaida MJ, Stead JA, Mcdowall KJ, Scott WG, Luisi BF. Structure of E. Coli Rnase E Catalytic Domain and Implications for RNA Processing and Turnover Nature. 437: 1187. DOI: 10.2210/Pdb2Bx2/Pdb  0.407
2005 Marcaida MJ, Callaghan A, Scott W, Symmons M, Chandran V, McDowall K, Stead J, Luisi B. Structure and function of RNase E and the RNA degradosome assembly Acta Crystallographica Section a Foundations of Crystallography. 61: c92-c92. DOI: 10.1107/S0108767305096108  0.463
2003 Dunham CM, Murray JB, Scott WG. A helical twist-induced conformational switch activates cleavage in the hammerhead ribozyme. Journal of Molecular Biology. 332: 327-36. PMID 12948485 DOI: 10.1016/S0022-2836(03)00843-X  0.672
2003 Dunham CM, Dioum EM, Tuckerman JR, Gonzalez G, Scott WG, Gilles-Gonzalez MA. A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure. Biochemistry. 42: 7701-8. PMID 12820879 DOI: 10.1021/Bi0343370  0.591
2002 Scott WG. Visualizing the structure and mechanism of a small nucleolytic ribozyme. Methods (San Diego, Calif.). 28: 302-6. PMID 12431434 DOI: 10.1016/S1046-2023(02)00237-2  0.417
2002 Burns CS, Aronoff-Spencer E, Dunham CM, Lario P, Avdievich NI, Antholine WE, Olmstead MM, Vrielink A, Gerfen GJ, Peisach J, Scott WG, Millhauser GL. Molecular features of the copper binding sites in the octarepeat domain of the prion protein. Biochemistry. 41: 3991-4001. PMID 11900542 DOI: 10.1021/Bi011922X  0.596
2002 Murray JB, Dunham CM, Scott WG. A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction. Journal of Molecular Biology. 315: 121-30. PMID 11779233 DOI: 10.1006/Jmbi.2001.5145  0.625
2001 Scott WG. Ribozyme catalysis via orbital steering. Journal of Molecular Biology. 311: 989-99. PMID 11531334 DOI: 10.1006/Jmbi.2001.4886  0.323
2000 Murray JB, Szöke H, Szöke A, Scott WG. Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction. Molecular Cell. 5: 279-87. PMID 10882069 DOI: 10.1016/S1097-2765(00)80423-2  0.444
2000 Scott WG, Murray JB. Conventional and time-resolved ribozyme X-ray crystallography. Methods in Enzymology. 317: 180-98. PMID 10829281 DOI: 10.1016/S0076-6879(00)17015-6  0.369
2000 Jovine L, Hainzl T, Oubridge C, Scott WG, Li J, Sixma TK, Wonacott A, Skarzynski T, Nagai K. Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA. Structure (London, England : 1993). 8: 527-40. PMID 10801497 DOI: 10.1016/S0969-2126(00)00137-4  0.529
2000 Murray JB, Scott WG. Does a single metal ion bridge the A-9 and scissile phosphate groups in the catalytically active hammerhead ribozyme structure? Journal of Molecular Biology. 296: 33-41. PMID 10656816 DOI: 10.1006/Jmbi.1999.3428  0.426
1999 Scott WG. Biophysical and biochemical investigations of RNA catalysis in the hammerhead ribozyme. Quarterly Reviews of Biophysics. 32: 241-84. PMID 11194566 DOI: 10.1017/S003358350000353X  0.572
1999 Scott WG. RNA structure, metal ions, and catalysis. Current Opinion in Chemical Biology. 3: 705-9. PMID 10600729 DOI: 10.1016/S1367-5931(99)00029-0  0.49
1998 Scott WG. RNA catalysis. Current Opinion in Structural Biology. 8: 720-6. PMID 9914252 DOI: 10.1016/S0959-440X(98)80091-2  0.424
1998 Murray JB, Seyhan AA, Walter NG, Burke JM, Scott WG. The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone. Chemistry & Biology. 5: 587-95. PMID 9818150 DOI: 10.1016/S1074-5521(98)90116-8  0.478
1998 Murray JB, Terwey DP, Maloney L, Karpeisky A, Usman N, Beigelman L, Scott WG. The structural basis of hammerhead ribozyme self-cleavage. Cell. 92: 665-73. PMID 9506521 DOI: 10.1016/S0092-8674(00)81134-4  0.493
1998 Feig AL, Scott WG, Uhlenbeck OC. Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb. Science (New York, N.Y.). 279: 81-4. PMID 9417029 DOI: 10.1126/Science.279.5347.81  0.371
1998 Stoddard BL, Bolduc JM, Dyer DH, Scott WG, Sweet RM. Visualizing enzyme and ribozyme intermediates using fast diffraction and reaction trapping methods Pure and Applied Chemistry. 70: 17-23. DOI: 10.1351/Pac199870010017  0.373
1997 Hermann T, Auffinger P, Scott WG, Westhof E. Evidence for a hydroxide ion bridging two magnesium ions at the active site of the hammerhead ribozyme. Nucleic Acids Research. 25: 3421-7. PMID 9254698 DOI: 10.1093/Nar/25.17.3421  0.461
1997 Scott WG. Crystallographic analyses of chemically synthesized modified hammerhead RNA sequences as a general approach toward understanding ribozyme structure and function. Methods in Molecular Biology (Clifton, N.J.). 74: 387-91. PMID 9204454 DOI: 10.1385/0-89603-389-9:387  0.481
1996 Scott WG, Murray JB, Arnold JR, Stoddard BL, Klug A. Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme. Science (New York, N.Y.). 274: 2065-9. PMID 8953035 DOI: 10.1126/Science.274.5295.2065  0.695
1996 Scott WG. Molecular palaeontology: understanding catalytic mechanisms in the RNA world by excavating clues from a ribozyme three-dimensional structure. Biochemical Society Transactions. 24: 604-8. PMID 8878812 DOI: 10.1042/Bst0240604  0.455
1996 Scott WG, Klug A. Ribozymes: structure and mechanism in RNA catalysis. Trends in Biochemical Sciences. 21: 220-4. PMID 8744356 DOI: 10.1016/S0968-0004(96)80019-3  0.667
1996 Scott WG, Finch JT, Klug A. The three-dimensional structure of an all-RNA hammerhead ribozyme Acta Crystallographica Section a Foundations of Crystallography. 52: C148-C148. DOI: 10.1107/S0108767396093336  0.658
1995 Scott WG, Finch JT, Klug A. The crystal structure of an all-RNA hammerhead ribozyme. Nucleic Acids Symposium Series. 214-6. PMID 8841628  0.646
1995 Bolduc JM, Dyer DH, Scott WG, Singer P, Sweet RM, Koshland DE, Stoddard BL. Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase. Science (New York, N.Y.). 268: 1312-8. PMID 7761851 DOI: 10.1126/Science.7761851  0.366
1995 Scott WG, Finch JT, Grenfell R, Fogg J, Smith T, Gait MJ, Klug A. Rapid crystallization of chemically synthesized hammerhead RNAs using a double screening procedure. Journal of Molecular Biology. 250: 327-32. PMID 7608978 DOI: 10.1006/Jmbi.1995.0380  0.602
1995 Scott WG, Finch JT, Klug A. The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage. Cell. 81: 991-1002. PMID 7541315 DOI: 10.1016/S0092-8674(05)80004-2  0.696
1994 Scott WG, Stoddard BL. Transmembrane signalling and the aspartate receptor Structure. 2: 877-887. PMID 7812719 DOI: 10.1016/S0969-2126(94)00088-3  0.309
1993 Scott WG, Milligan DL, Milburn MV, Privé GG, Yeh J, Koshland DE, Kim SH. Refined structures of the ligand-binding domain of the aspartate receptor from Salmonella typhimurium Journal of Molecular Biology. 232: 555-573. PMID 8345523 DOI: 10.1006/Jmbi.1993.1411  0.702
1992 Kim SH, Prive GG, Yeh J, Scott WG, Milburn MV. A model for transmembrane signaling in a bacterial chemotaxis receptor Cold Spring Harbor Symposia On Quantitative Biology. 57: 17-24. PMID 1339657 DOI: 10.1101/Sqb.1992.057.01.004  0.643
1991 Milburn MV, Privé GG, Milligan DL, Scott WG, Yeh J, Jancarik J, Koshland DE, Kim SH. Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand Science. 254: 1342-1347. PMID 1660187 DOI: 10.1126/Science.1660187  0.711
1991 Jancarik J, Scott WG, Milligan DL, Koshland DE, Kim SH. Crystallization and preliminary X-ray diffraction study of the ligand-binding domain of the bacterial chemotaxis-mediating aspartate receptor of Salmonella typhimurium Journal of Molecular Biology. 221: 31-34. PMID 1656050 DOI: 10.1016/0022-2836(91)80198-4  0.54
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