Steven C. Leiser, Ph.D.

Affiliations: 
Synaptic Transmission Lundbeck Research USA 
Area:
Electrophysiology
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"Steven Leiser"
Cross-listing: Neurotree

Parents

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John K. Chapin research assistant 1999 Drexel (Neurotree)
Karen A. Moxon grad student 2005 Drexel Medical School (Neurotree)
 (Fundamental properties of rapidly and slowly adapting cells in the trigeminal ganglion of the awake freely moving rat.)
Rita J. Valentino post-doc Children’s Hospital of Philadelphia / University of Pennsylvania (Neurotree)
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Publications

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Dale E, Pehrson AL, Jeyarajah T, et al. (2015) Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function. Cns Spectrums. 1-19
Leiser SC, Iglesias-Bregna D, Westrich L, et al. (2015) Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism. Journal of Psychopharmacology (Oxford, England). 29: 1092-105
Leiser SC, Li Y, Pehrson AL, et al. (2015) Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine. Acs Chemical Neuroscience. 6: 970-86
Pehrson AL, Leiser SC, Gulinello M, et al. (2015) Treatment of cognitive dysfunction in major depressive disorder--a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine. European Journal of Pharmacology. 753: 19-31
Dale E, Zhang H, Leiser SC, et al. (2014) Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. Journal of Psychopharmacology (Oxford, England). 28: 891-902
Leiser SC, Pehrson AL, Robichaud PJ, et al. (2014) Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine--a quantitative EEG study in rats. British Journal of Pharmacology. 171: 4255-72
Wilson FJ, Leiser SC, Ivarsson M, et al. (2014) Can pharmaco-electroencephalography help improve survival of central nervous system drugs in early clinical development? Drug Discovery Today. 19: 282-8
Corbett BF, Leiser SC, Ling HP, et al. (2013) Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7020-6
Featherstone RE, Phillips JM, Thieu T, et al. (2012) Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials. Plos One. 7: e39775
Curtis AL, Leiser SC, Snyder K, et al. (2012) Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons. Neuropharmacology. 62: 1737-45
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