Matthew D. Hirschey, Ph.D. - Publications

Affiliations: 
University of California, Santa Barbara, Santa Barbara, CA, United States 
Area:
bioinorganic chemistry and metallobiochemistry

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Bhatt DP, Mills CA, Anderson KA, Henriques BJ, Lucas TG, Francisco S, Liu J, Ilkayeva OR, Adams AE, Kulkarni SR, Backos DS, Major MB, Grimsrud PA, Gomes CM, Hirschey MD. Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice. The Journal of Biological Chemistry. 101723. PMID 35157847 DOI: 10.1016/j.jbc.2022.101723  0.336
2020 Gonzalez-Hunt CP, Luz AL, Ryde IT, Turner EA, Ilkayeva OR, Bhatt DP, Hirschey MD, Meyer JN. Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone. Toxicology. 152630. PMID 33188857 DOI: 10.1016/j.tox.2020.152630  0.312
2019 Naiman S, Huynh FK, Gil R, Glick Y, Shahar Y, Touitou N, Nahum L, Avivi MY, Roichman A, Kanfi Y, Gertler AA, Doniger T, Ilkayeva OR, Abramovich I, Yaron O, ... ... Hirschey MD, et al. SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell Reports. 29: 4127-4143.e8. PMID 31851938 DOI: 10.1016/J.Celrep.2019.11.067  0.41
2019 Assiri MA, Ali HR, Marentette JO, Yun Y, Liu J, Hirschey MD, Saba LM, Harris PS, Fritz KS. Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease. Human Genomics. 13: 65. PMID 31823815 DOI: 10.1186/S40246-019-0251-1  0.316
2019 Ali HR, Assiri MA, Harris PS, Michel CR, Yun Y, Marentette JO, Huynh FK, Orlicky DJ, Shearn CT, Saba LM, Reisdorph R, Reisdorph N, Hirschey MD, Fritz KS. Quantifying competition among mitochondrial protein acylation events induced by ethanol metabolism. Journal of Proteome Research. PMID 30644754 DOI: 10.1021/Acs.Jproteome.8B00800  0.44
2018 Mills CA, Trub AG, Hirschey MD. Sensing Mitochondrial Acetyl-CoA to Tune Respiration. Trends in Endocrinology and Metabolism: Tem. PMID 30442533 DOI: 10.1016/J.Tem.2018.10.003  0.403
2018 Peterson BS, Campbell JE, Ilkayeva O, Grimsrud PA, Hirschey MD, Newgard CB. Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition. Cell Reports. 24: 209-223.e6. PMID 29972782 DOI: 10.1016/J.Celrep.2018.05.088  0.447
2018 Hershberger KA, Abraham DM, Liu J, Locasale JW, Grimsrud PA, Hirschey MD. Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload. The Journal of Biological Chemistry. PMID 29769314 DOI: 10.1074/Jbc.Ra118.002187  0.381
2018 Trub AG, Hirschey MD. Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress. Trends in Biochemical Sciences. PMID 29478872 DOI: 10.1016/J.Tibs.2018.02.002  0.435
2017 Hu Y, Semova I, Sun X, Kang H, Chahar S, Hollenberg AN, Masson D, Hirschey MD, Miao J, Biddinger SB. Fructose and glucose regulate mammalian target of rapamycin complex 1 and can activate lipogenic gene expression via distinct pathways. The Journal of Biological Chemistry. PMID 29222328 DOI: 10.1074/Jbc.M117.782557  0.305
2017 Weir HJ, Yao P, Huynh FK, Escoubas CC, Goncalves RL, Burkewitz K, Laboy R, Hirschey MD, Mair WB. Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. Cell Metabolism. PMID 29107506 DOI: 10.1016/J.Cmet.2017.09.024  0.398
2017 Hibshman JD, Doan AE, Moore BT, Kaplan RE, Hung A, Webster AK, Bhatt DP, Chitrakar R, Hirschey MD, Baugh LR. daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival. Elife. 6. PMID 29063832 DOI: 10.7554/Elife.30057  0.373
2017 Hershberger KA, Abraham DM, Martin AS, Mao L, Liu J, Gu H, Locasale JW, Hirschey MD. Sirtuin 5 is required for mouse survival in response to cardiac pressure overload. The Journal of Biological Chemistry. PMID 28972174 DOI: 10.1074/Jbc.M117.809897  0.436
2017 Anderson KA, Madsen AS, Olsen CA, Hirschey MD. Metabolic control by sirtuins and other enzymes that sense NAD(+), NADH, or their ratio. Biochimica Et Biophysica Acta. PMID 28947253 DOI: 10.1016/J.Bbabio.2017.09.005  0.347
2017 Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS. Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. Alcoholism, Clinical and Experimental Research. PMID 28804911 DOI: 10.1111/Acer.13473  0.383
2017 Huynh FK, Hu X, Lin Z, Johnson JD, Hirschey MD. Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. Journal of Inherited Metabolic Disease. PMID 28726069 DOI: 10.1007/S10545-017-0069-8  0.403
2017 Martin AS, Abraham DM, Hershberger KA, Bhatt DP, Mao L, Cui H, Liu J, Liu X, Muehlbauer MJ, Grimsrud PA, Locasale JW, Payne RM, Hirschey MD. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model. Jci Insight. 2. PMID 28724806 DOI: 10.1172/Jci.Insight.93885  0.4
2017 Stram AR, Wagner GR, Fogler BD, Pride PM, Hirschey MD, Payne RM. Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy. Plos One. 12: e0178354. PMID 28542596 DOI: 10.1371/Journal.Pone.0178354  0.359
2017 Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, ... ... Hirschey MD, et al. SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell Metabolism. 25: 838-855.e15. PMID 28380376 DOI: 10.1016/J.Cmet.2017.03.003  0.435
2017 Wagner GR, Bhatt DP, O'Connell TM, Thompson JW, Dubois LG, Backos DS, Yang H, Mitchell GA, Ilkayeva OR, Stevens RD, Grimsrud PA, Hirschey MD. A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation. Cell Metabolism. 25: 823-837.e8. PMID 28380375 DOI: 10.1016/J.Cmet.2017.03.006  0.42
2017 Wagner GR, Hirschey MD. A Prob(e)able Route to Lysine Acylation. Cell Chemical Biology. 24: 126-128. PMID 28212757 DOI: 10.1016/J.Chembiol.2017.01.011  0.374
2017 Hershberger KA, Martin AS, Hirschey MD. Role of NAD(+) and mitochondrial sirtuins in cardiac and renal diseases. Nature Reviews. Nephrology. PMID 28163307 DOI: 10.1038/Nrneph.2017.5  0.396
2016 McDonnell E, Crown SB, Fox DB, Kitir B, Ilkayeva OR, Olsen CA, Grimsrud PA, Hirschey MD. Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation. Cell Reports. 17: 1463-1472. PMID 27806287 DOI: 10.1016/J.Celrep.2016.10.012  0.389
2016 Luz AT, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN. Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans. Toxicological Sciences : An Official Journal of the Society of Toxicology. 154: 195. PMID 27794142 DOI: 10.1093/Toxsci/Kfw185  0.37
2016 Luz AL, Lagido C, Hirschey MD, Meyer JN. In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. 69: 25.8.1-25.8.22. PMID 27479364 DOI: 10.1002/Cptx.10  0.417
2016 Luz AL, Godebo T, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN. Arsenite uncouples mitochondrial respiration and induces a Warburg-like effect in Caenorhabditis elegans. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27208080 DOI: 10.1093/Toxsci/Kfw093  0.431
2016 Madsen AS, Andersen C, Daoud M, Anderson KA, Laursen JS, Chakladar S, Huynh FK, Colaço AR, Backos DS, Fristrup P, Hirschey MD, Olsen CA. Investigating the Sensitivity of NAD+-Dependent Sirtuin Deacylation Activities to NADH. The Journal of Biological Chemistry. PMID 26861872 DOI: 10.1074/Jbc.M115.668699  0.32
2015 Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002  0.303
2015 Huynh FK, Muoio DM, Hirschey MD. SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control. Diabetes. 64: 3058-60. PMID 26294425 DOI: 10.2337/Db15-0709  0.457
2015 Otsubo C, Bharathi S, Uppala R, Ilkayeva OR, Wang D, McHugh K, Zou Y, Wang J, Alcorn JF, Zuo YY, Hirschey MD, Goetzman ES. Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant. The Journal of Biological Chemistry. PMID 26240137 DOI: 10.1074/Jbc.M115.655837  0.32
2015 McDonnell E, Peterson BS, Bomze HM, Hirschey MD. SIRT3 regulates progression and development of diseases of aging. Trends in Endocrinology and Metabolism: Tem. PMID 26138757 DOI: 10.1016/J.Tem.2015.06.001  0.413
2015 Liu X, Sadhukhan S, Sun S, Wagner GR, Hirschey MD, Qi L, Lin H, Locasale JW. High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet. Molecular & Cellular Proteomics : McP. 14: 1489-500. PMID 25795660 DOI: 10.1074/Mcp.M114.044859  0.415
2015 Burkewitz K, Morantte I, Weir HJ, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB. Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell. 160: 842-55. PMID 25723162 DOI: 10.1016/J.Cell.2015.02.004  0.447
2015 Hirschey MD, Zhao Y. Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. Molecular & Cellular Proteomics : McP. 14: 2308-15. PMID 25717114 DOI: 10.1074/Mcp.R114.046664  0.429
2014 Anderson KA, Green MF, Huynh FK, Wagner GR, Hirschey MD. SnapShot: Mammalian Sirtuins. Cell. 159: 956-956.e1. PMID 25417168 DOI: 10.1016/J.Cell.2014.10.045  0.358
2014 Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, et al. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environmental Health Perspectives. 122: 1271-8. PMID 25127496 DOI: 10.1289/Ehp.1408418  0.4
2014 Moffat C, Bhatia L, Nguyen T, Lynch P, Wang M, Wang D, Ilkayeva OR, Han X, Hirschey MD, Claypool SM, Seifert EL. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver. Journal of Lipid Research. 55: 2458-70. PMID 25114170 DOI: 10.1194/Jlr.M046961  0.399
2014 Huynh FK, Green MF, Koves TR, Hirschey MD. Measurement of fatty acid oxidation rates in animal tissues and cell lines. Methods in Enzymology. 542: 391-405. PMID 24862277 DOI: 10.1016/B978-0-12-416618-9.00020-0  0.339
2014 Wagner GR, Hirschey MD. Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases. Molecular Cell. 54: 5-16. PMID 24725594 DOI: 10.1016/J.Molcel.2014.03.027  0.377
2014 Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, ... ... Hirschey MD, et al. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metabolism. 19: 605-17. PMID 24703693 DOI: 10.1016/J.Cmet.2014.03.014  0.43
2014 McDonnell E, Ilkayeva OR, Stevens RD, Muehlbauer MJ, Bain JR, Becker TC, Hirschey MD. Loss of SIRT3 leads to a compensatory shift in cellular metabolism promoting cancer cell growth Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-O18  0.493
2014 Hirschey M. Protein Acylation Regulates Metabolism Biophysical Journal. 106: 4a. DOI: 10.1016/J.Bpj.2013.11.053  0.461
2013 Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES. Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. The Journal of Biological Chemistry. 288: 33837-47. PMID 24121500 DOI: 10.1074/Jbc.M113.510354  0.384
2013 Fritz KS, Green MF, Petersen DR, Hirschey MD. Ethanol metabolism modifies hepatic protein acylation in mice. Plos One. 8: e75868. PMID 24073283 DOI: 10.1371/Journal.Pone.0075868  0.48
2013 Wang D, Green MF, McDonnell E, Hirschey MD. Oxygen flux analysis to understand the biological function of sirtuins. Methods in Molecular Biology (Clifton, N.J.). 1077: 241-58. PMID 24014411 DOI: 10.1007/978-1-62703-637-5_16  0.454
2013 Hershberger KA, Motley J, Hirschey MD, Anderson KA. Generating mammalian sirtuin tools for protein-interaction analysis. Methods in Molecular Biology (Clifton, N.J.). 1077: 69-78. PMID 24014400 DOI: 10.1007/978-1-62703-637-5_5  0.346
2013 Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, N.Y.). 339: 211-4. PMID 23223453 DOI: 10.1126/Science.1227166  0.334
2013 Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nature Chemical Biology. 9: 97-104. PMID 23201900 DOI: 10.1038/Nchembio.1136  0.385
2013 Anderson KA, Wang D, Hirschey MD. HINT2 and fatty liver disease: mitochondrial protein hyperacetylation gives a hint? Hepatology (Baltimore, Md.). 57: 1681-3. PMID 22991239 DOI: 10.1002/Hep.26085  0.495
2013 Green MF, Hirschey MD. SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 105-7. PMID 22562958 DOI: 10.1093/Gerona/Gls132  0.46
2012 Anderson KA, Hirschey MD. Mitochondrial protein acetylation regulates metabolism. Essays in Biochemistry. 52: 23-35. PMID 22708561 DOI: 10.1042/Bse0520023  0.469
2012 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR. Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. Journal of Proteome Research. 11: 1633-43. PMID 22309199 DOI: 10.1016/J.Freeradbiomed.2011.10.044  0.468
2011 Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E. SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harbor Symposia On Quantitative Biology. 76: 267-77. PMID 22114326 DOI: 10.1101/Sqb.2011.76.010850  0.49
2011 Hirschey MD. Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases. Cell Metabolism. 14: 718-9. PMID 22100408 DOI: 10.1016/J.Cmet.2011.10.006  0.318
2011 Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proceedings of the National Academy of Sciences of the United States of America. 108: 14608-13. PMID 21873205 DOI: 10.1073/Pnas.1111308108  0.39
2011 Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Molecular Cell. 44: 177-90. PMID 21856199 DOI: 10.1016/J.Molcel.2011.07.019  0.473
2010 Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metabolism. 12: 662-7. PMID 21109198 DOI: 10.1016/J.Cmet.2010.11.015  0.348
2010 Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metabolism. 12: 654-61. PMID 21109197 DOI: 10.1016/J.Cmet.2010.11.003  0.461
2010 Verdin E, Hirschey MD, Finley LW, Haigis MC. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends in Biochemical Sciences. 35: 669-75. PMID 20863707 DOI: 10.1016/J.Tibs.2010.07.003  0.459
2010 Shimazu T, Hirschey MD, Huang JY, Ho LT, Verdin E. Acetate metabolism and aging: An emerging connection. Mechanisms of Ageing and Development. 131: 511-6. PMID 20478325 DOI: 10.1016/J.Mad.2010.05.001  0.461
2010 Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/Nature08778  0.479
2010 Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E. Mitochondrial sirtuins. Biochimica Et Biophysica Acta. 1804: 1645-51. PMID 20060508 DOI: 10.1016/j.bbapap.2009.12.021  0.393
2009 Hirschey MD, Shimazu T, Huang JY, Verdin E. Acetylation of mitochondrial proteins. Methods in Enzymology. 457: 137-47. PMID 19426866 DOI: 10.1016/S0076-6879(09)05008-3  0.487
2007 Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/Mcb.01636-07  0.482
2006 Hirschey MD, Han YJ, Stucky GD, Butler A. Imaging Escherichia coli using functionalized core/shell CdSe/CdS quantum dots. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 11: 663-9. PMID 16724226 DOI: 10.1007/S00775-006-0116-7  0.55
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