Year |
Citation |
Score |
2021 |
Grieve AG, Yeh YC, Chang YF, Huang HY, Zarcone L, Breuning J, Johnson N, Stříšovský K, Brown MH, Parekh AB, Freeman M. Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation. Molecular Cell. PMID 34800360 DOI: 10.1016/j.molcel.2021.10.025 |
0.667 |
|
2020 |
Muliyil S, Levet C, Düsterhöft S, Dulloo I, Cowley SA, Freeman M. ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration. The Embo Journal. e104415. PMID 32715522 DOI: 10.15252/embj.2020104415 |
0.316 |
|
2020 |
Liu G, Beaton SE, Grieve AG, Evans R, Rogers M, Strisovsky K, Armstrong FA, Freeman M, Exley RM, Tang CM. Bacterial rhomboid proteases mediate quality control of orphan membrane proteins. The Embo Journal. e102922. PMID 32337752 DOI: 10.15252/Embj.2019102922 |
0.703 |
|
2020 |
Freeman M. Rhomboid Proteins in Cell Signaling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00127 |
0.344 |
|
2019 |
Ikeda KN, Freeman M. Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4. The Journal of Biological Chemistry. PMID 31177093 DOI: 10.1074/jbc.RA118.007074 |
0.375 |
|
2019 |
Dulloo I, Muliyil S, Freeman M. The molecular, cellular and pathophysiological roles of iRhom pseudoproteases. Open Biology. 9: 190003. PMID 30890028 DOI: 10.1098/rsob.190003 |
0.39 |
|
2018 |
Künzel U, Grieve AG, Meng Y, Sieber B, Cowley SA, Freeman M. FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. Elife. 7. PMID 29897336 DOI: 10.7554/eLife.35012 |
0.399 |
|
2017 |
Johnson N, Březinová J, Stephens E, Burbridge E, Freeman M, Adrain C, Strisovsky K. Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis. Scientific Reports. 7: 7283. PMID 28779096 DOI: 10.1038/s41598-017-07556-3 |
0.727 |
|
2017 |
Düsterhöft S, Künzel U, Freeman M. Rhomboid proteases in human disease: Mechanisms and future prospects. Biochimica Et Biophysica Acta. PMID 28460881 DOI: 10.1016/j.bbamcr.2017.04.016 |
0.349 |
|
2017 |
Grieve AG, Xu H, Künzel U, Bambrough P, Sieber B, Freeman M. Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling. Elife. 6. PMID 28432785 DOI: 10.7554/eLife.23968 |
0.389 |
|
2016 |
Lorenzen I, Lokau J, Korpys Y, Oldefest M, Flynn CM, Künzel U, Garbers C, Freeman M, Grötzinger J, Düsterhöft S. Control of ADAM17 activity by regulation of its cellular localisation. Scientific Reports. 6: 35067. PMID 27731361 DOI: 10.1038/srep35067 |
0.404 |
|
2016 |
Lastun VL, Grieve A, Freeman M. Substrates and physiological functions of secretase rhomboid proteases. Seminars in Cell & Developmental Biology. PMID 27497690 DOI: 10.1016/j.semcdb.2016.07.033 |
0.348 |
|
2016 |
Freeman M. Rhomboids, signalling and cell biology. Biochemical Society Transactions. 44: 945-50. PMID 27284064 DOI: 10.1042/BST20160035 |
0.369 |
|
2016 |
Wunderle L, Knopf JD, Kühnle N, Morlé A, Hehn B, Adrain C, Strisovsky K, Freeman M, Lemberg MK. Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα. Scientific Reports. 6: 27342. PMID 27264103 DOI: 10.1038/srep27342 |
0.724 |
|
2014 |
Siggs OM, Grieve A, Xu H, Bambrough P, Christova Y, Freeman M. Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice. Biology Open. 3: 1151-7. PMID 25395669 DOI: 10.1242/bio.201410116 |
0.412 |
|
2014 |
Freeman M. The rhomboid-like superfamily: molecular mechanisms and biological roles. Annual Review of Cell and Developmental Biology. 30: 235-54. PMID 25062361 DOI: 10.1146/annurev-cellbio-100913-012944 |
0.403 |
|
2014 |
Strisovsky K, Freeman M. Sharpening rhomboid specificity by dimerisation and allostery. The Embo Journal. 33: 1847-8. PMID 25027763 DOI: 10.15252/embj.201489373 |
0.683 |
|
2014 |
Adrain C, Freeman M. Regulation of receptor tyrosine kinase ligand processing. Cold Spring Harbor Perspectives in Biology. 6. PMID 24384567 DOI: 10.1101/cshperspect.a008995 |
0.37 |
|
2013 |
Christova Y, Adrain C, Bambrough P, Ibrahim A, Freeman M. Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation. Embo Reports. 14: 884-90. PMID 23969955 DOI: 10.1038/embor.2013.128 |
0.344 |
|
2013 |
Vinothkumar KR, Freeman M. Intramembrane proteolysis by rhomboids: catalytic mechanisms and regulatory principles. Current Opinion in Structural Biology. 23: 851-8. PMID 23937901 DOI: 10.1016/j.sbi.2013.07.014 |
0.391 |
|
2013 |
Vinothkumar KR, Pierrat OA, Large JM, Freeman M. Structure of rhomboid protease in complex with β-lactam inhibitors defines the S2' cavity. Structure (London, England : 1993). 21: 1051-8. PMID 23665170 DOI: 10.1016/j.str.2013.03.013 |
0.323 |
|
2013 |
Aldaz S, Escudero LM, Freeman M. Dual role of myosin II during Drosophila imaginal disc metamorphosis. Nature Communications. 4: 1761. PMID 23612302 DOI: 10.1038/Ncomms2763 |
0.672 |
|
2012 |
Adrain C, Freeman M. New lives for old: evolution of pseudoenzyme function illustrated by iRhoms. Nature Reviews. Molecular Cell Biology. 13: 489-98. PMID 22781900 DOI: 10.1038/nrm3392 |
0.347 |
|
2012 |
Adrain C, Zettl M, Christova Y, Taylor N, Freeman M. Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science (New York, N.Y.). 335: 225-8. PMID 22246777 DOI: 10.1126/science.1214400 |
0.335 |
|
2011 |
Escudero LM, Costa Lda F, Kicheva A, Briscoe J, Freeman M, Babu MM. Epithelial organisation revealed by a network of cellular contacts. Nature Communications. 2: 526. PMID 22068593 DOI: 10.1038/Ncomms1536 |
0.676 |
|
2011 |
Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M. Mammalian EGF receptor activation by the rhomboid protease RHBDL2. Embo Reports. 12: 421-7. PMID 21494248 DOI: 10.1038/embor.2011.50 |
0.709 |
|
2011 |
Zettl M, Adrain C, Strisovsky K, Lastun V, Freeman M. Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Cell. 145: 79-91. PMID 21439629 DOI: 10.1016/j.cell.2011.02.047 |
0.728 |
|
2011 |
Pierrat OA, Strisovsky K, Christova Y, Large J, Ansell K, Bouloc N, Smiljanic E, Freeman M. Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases. Acs Chemical Biology. 6: 325-35. PMID 21175222 DOI: 10.1021/cb100314y |
0.682 |
|
2010 |
Vinothkumar KR, Strisovsky K, Andreeva A, Christova Y, Verhelst S, Freeman M. The structural basis for catalysis and substrate specificity of a rhomboid protease. The Embo Journal. 29: 3797-809. PMID 20890268 DOI: 10.1038/emboj.2010.243 |
0.697 |
|
2010 |
Aldaz S, Escudero LM, Freeman M. Live imaging of Drosophila imaginal disc development. Proceedings of the National Academy of Sciences of the United States of America. 107: 14217-22. PMID 20660765 DOI: 10.1073/Pnas.1008623107 |
0.66 |
|
2009 |
Strisovsky K, Sharpe HJ, Freeman M. Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates. Molecular Cell. 36: 1048-59. PMID 20064469 DOI: 10.1016/j.molcel.2009.11.006 |
0.701 |
|
2009 |
Mao Y, Freeman M. Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling. Development (Cambridge, England). 136: 473-81. PMID 19141676 DOI: 10.1242/dev.026054 |
0.416 |
|
2009 |
Blobel CP, Carpenter G, Freeman M. The role of protease activity in ErbB biology. Experimental Cell Research. 315: 671-82. PMID 19013149 DOI: 10.1016/J.Yexcr.2008.10.011 |
0.356 |
|
2008 |
Freeman M. Rhomboid proteases and their biological functions. Annual Review of Genetics. 42: 191-210. PMID 18605900 DOI: 10.1146/annurev.genet.42.110807.091628 |
0.405 |
|
2008 |
Mao Y, Kerr M, Freeman M. Modulation of Drosophila retinal epithelial integrity by the adhesion proteins capricious and tartan. Plos One. 3: e1827. PMID 18350163 DOI: 10.1371/journal.pone.0001827 |
0.374 |
|
2007 |
Lemberg MK, Freeman M. Cutting proteins within lipid bilayers: rhomboid structure and mechanism. Molecular Cell. 28: 930-40. PMID 18158892 DOI: 10.1016/j.molcel.2007.12.003 |
0.315 |
|
2007 |
Escudero LM, Bischoff M, Freeman M. Myosin II regulates complex cellular arrangement and epithelial architecture in Drosophila. Developmental Cell. 13: 717-29. PMID 17981139 DOI: 10.1016/J.Devcel.2007.09.002 |
0.701 |
|
2007 |
Lemberg MK, Freeman M. Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases. Genome Research. 17: 1634-46. PMID 17938163 DOI: 10.1101/gr.6425307 |
0.396 |
|
2007 |
Brown KE, Kerr M, Freeman M. The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye. Developmental Biology. 307: 105-13. PMID 17512517 DOI: 10.1016/j.ydbio.2007.04.025 |
0.397 |
|
2007 |
Escudero LM, Freeman M. Mechanism of G1 arrest in the Drosophila eye imaginal disc. Bmc Developmental Biology. 7: 13. PMID 17335573 DOI: 10.1186/1471-213X-7-13 |
0.675 |
|
2007 |
Stevenson LG, Strisovsky K, Clemmer KM, Bhatt S, Freeman M, Rather PN. Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase. Proceedings of the National Academy of Sciences of the United States of America. 104: 1003-8. PMID 17215357 DOI: 10.1073/Pnas.0608140104 |
0.71 |
|
2006 |
Brown KE, Baonza A, Freeman M. Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway. Developmental Biology. 300: 710-21. PMID 16963016 DOI: 10.1016/j.ydbio.2006.08.003 |
0.392 |
|
2006 |
McQuibban GA, Lee JR, Zheng L, Juusola M, Freeman M. Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. Current Biology : Cb. 16: 982-9. PMID 16713954 DOI: 10.1016/J.Cub.2006.03.062 |
0.701 |
|
2006 |
Charroux B, Freeman M, Kerridge S, Baonza A. Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila. Developmental Biology. 291: 278-90. PMID 16445904 DOI: 10.1016/j.ydbio.2005.12.012 |
0.41 |
|
2005 |
Kanaoka MM, Urban S, Freeman M, Okada K. An Arabidopsis Rhomboid homolog is an intramembrane protease in plants. Febs Letters. 579: 5723-8. PMID 16223493 DOI: 10.1016/j.febslet.2005.09.049 |
0.396 |
|
2005 |
Baonza A, Freeman M. Control of cell proliferation in the Drosophila eye by Notch signaling. Developmental Cell. 8: 529-39. PMID 15809035 DOI: 10.1016/j.devcel.2005.01.019 |
0.408 |
|
2005 |
Lemberg MK, Menendez J, Misik A, Garcia M, Koth CM, Freeman M. Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. The Embo Journal. 24: 464-72. PMID 15616571 DOI: 10.1038/Sj.Emboj.7600537 |
0.371 |
|
2004 |
Urban S, Brown G, Freeman M. EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development (Cambridge, England). 131: 1835-45. PMID 15084467 DOI: 10.1242/dev.01058 |
0.386 |
|
2004 |
Freeman M. Proteolysis within the membrane: rhomboids revealed. Nature Reviews. Molecular Cell Biology. 5: 188-97. PMID 14990999 DOI: 10.1038/nrm1334 |
0.361 |
|
2004 |
Lohi O, Urban S, Freeman M. Diverse substrate recognition mechanisms for rhomboids; thrombomodulin is cleaved by Mammalian rhomboids. Current Biology : Cb. 14: 236-41. PMID 14761657 DOI: 10.1016/j.cub.2004.01.025 |
0.434 |
|
2003 |
Brown KE, Freeman M. Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye. Development (Cambridge, England). 130: 5401-12. PMID 14507785 DOI: 10.1242/dev.00773 |
0.361 |
|
2003 |
Urban S, Freeman M. Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Molecular Cell. 11: 1425-34. PMID 12820957 DOI: 10.1016/S1097-2765(03)00181-3 |
0.394 |
|
2003 |
McQuibban GA, Saurya S, Freeman M. Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature. 423: 537-41. PMID 12774122 DOI: 10.1038/Nature01633 |
0.726 |
|
2002 |
Baonza A, Murawsky CM, Travers AA, Freeman M. Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis. Nature Cell Biology. 4: 976-80. PMID 12447387 DOI: 10.1038/ncb887 |
0.409 |
|
2002 |
Baonza A, Freeman M. Control of Drosophila eye specification by Wingless signalling. Development (Cambridge, England). 129: 5313-22. PMID 12403704 DOI: 10.1242/dev.00096 |
0.335 |
|
2002 |
Urban S, Schlieper D, Freeman M. Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids Current Biology. 12: 1507-1512. PMID 12225666 DOI: 10.1016/S0960-9822(02)01092-8 |
0.421 |
|
2002 |
Urban S, Freeman M. Intramembrane proteolysis controls diverse signalling pathways throughout evolution Current Opinion in Genetics and Development. 12: 512-518. PMID 12200155 DOI: 10.1016/S0959-437X(02)00334-9 |
0.375 |
|
2002 |
Urban S, Lee JR, Freeman M. A family of rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands Embo Journal. 21: 4277-4286. PMID 12169630 DOI: 10.1093/emboj/cdf434 |
0.391 |
|
2001 |
Urban S, Lee JR, Freeman M. Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases Cell. 107: 173-182. PMID 11672525 DOI: 10.1016/S0092-8674(01)00525-6 |
0.39 |
|
2001 |
Lee JR, Urban S, Garvey CF, Freeman M. Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila Cell. 107: 161-171. PMID 11672524 DOI: 10.1016/S0092-8674(01)00526-8 |
0.404 |
|
2001 |
Freeman M. Pin-pointing MAPK signalling Nature Cell Biology. 3: E136-E137. PMID 11389451 DOI: 10.1038/35078599 |
0.352 |
|
2001 |
Baonza A, Casci T, Freeman M. A primary role for the epidermal growth factor receptor in ommatidial spacing in the Drosophila eye. Current Biology : Cb. 11: 396-404. PMID 11301250 DOI: 10.1016/S0960-9822(01)00125-7 |
0.377 |
|
2001 |
Freeman M, Bienz M. EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye. Embo Reports. 2: 157-62. PMID 11258709 DOI: 10.1093/Embo-Reports/Kve019 |
0.371 |
|
2000 |
Freeman M. Feedback control of intercellular signalling in development Nature. 408: 313-319. PMID 11099031 DOI: 10.1038/35042500 |
0.325 |
|
2000 |
Vinós J, Freeman M. Evidence that Argos is an antagonistic ligand of the EGF receptor. Oncogene. 19: 3560-2. PMID 10918615 DOI: 10.1038/sj.onc.1203702 |
0.353 |
|
2000 |
Munro S, Freeman M. The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. Current Biology : Cb. 10: 813-20. PMID 10899003 DOI: 10.1016/S0960-9822(00)00578-9 |
0.429 |
|
2000 |
Wasserman JD, Urban S, Freeman M. A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling Genes and Development. 14: 1651-1663. PMID 10887159 DOI: 10.1101/Gad.14.13.1651 |
0.439 |
|
1999 |
Casci T, Freeman M. Control of EGF receptor signalling: Lessons from fruitflies Cancer and Metastasis Reviews. 18: 181-201. PMID 10728983 DOI: 10.1023/A:1006313122373 |
0.349 |
|
1999 |
Casci T, Vinós J, Freeman M. Sprouty, an intracellular inhibitor of Ras signaling. Cell. 96: 655-65. PMID 10089881 DOI: 10.1016/S0092-8674(00)80576-0 |
0.373 |
|
1999 |
Nagaraj R, Pickup AT, Howes R, Moses K, Freeman M, Banerjee U. Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial. Development (Cambridge, England). 126: 975-85. PMID 9927598 |
0.569 |
|
1998 |
Wasserman JD, Freeman M. An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg Cell. 95: 355-364. PMID 9814706 DOI: 10.1016/S0092-8674(00)81767-5 |
0.383 |
|
1998 |
Domínguez M, Wasserman JD, Freeman M. Multiple functions of the EGF receptor in Drosophila eye development Current Biology. 8: 1039-1048. PMID 9768358 DOI: 10.1016/S0960-9822(98)70441-5 |
0.393 |
|
1998 |
Freeman M. Complexity of EGF receptor signalling revealed in Drosophila Current Opinion in Genetics and Development. 8: 407-411. PMID 9729715 DOI: 10.1016/S0959-437X(98)80110-X |
0.383 |
|
1998 |
Howes R, Wasserman JD, Freeman M. In vivo analysis of Argos structure-function. Sequence requirements for inhibition of the Drosophila epidermal growth factor receptor Journal of Biological Chemistry. 273: 4275-4281. PMID 9461626 DOI: 10.1074/jbc.273.7.4275 |
0.372 |
|
1997 |
Wasserman JD, Freeman M. Control of EGF receptor activation in Drosophila Trends in Cell Biology. 7: 431-436. DOI: 10.1016/S0962-8924(97)01143-4 |
0.36 |
|
1996 |
Freeman M. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye Cell. 87: 651-660. PMID 8929534 DOI: 10.1016/S0092-8674(00)81385-9 |
0.367 |
|
1995 |
Schweitzer R, Howes R, Smith R, Shilo BZ, Freeman M. Inhibition of Drosophila EGF receptor activation by the secreted protein Argos Nature. 376: 699-702. PMID 7651519 DOI: 10.1038/376699a0 |
0.411 |
|
1994 |
Freeman M. The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor Mechanisms of Development. 48: 25-33. PMID 7833286 DOI: 10.1016/0925-4773(94)90003-5 |
0.363 |
|
1992 |
Freeman M, Klämbt C, Goodman CS, Rubin GM. The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye. Cell. 69: 963-75. PMID 1606617 DOI: 10.1016/0092-8674(92)90615-J |
0.546 |
|
1992 |
Freeman M, Kimmel BE, Rubin GM. Identifying targets of the rough homeobox gene of Drosophila: evidence that rhomboid functions in eye development. Development (Cambridge, England). 116: 335-46. PMID 1363086 |
0.673 |
|
1991 |
Lee KJ, Freeman M, Steller H. Expression of the disconnected gene during development of Drosophila melanogaster. The Embo Journal. 10: 817-26. PMID 1901263 DOI: 10.1002/J.1460-2075.1991.Tb08014.X |
0.594 |
|
1991 |
Heilig JS, Freeman M, Laverty T, Lee KJ, Campos AR, Rubin GM, Steller H. Isolation and characterization of the disconnected gene of Drosophila melanogaster. The Embo Journal. 10: 809-15. PMID 1901262 DOI: 10.1002/J.1460-2075.1991.Tb08013.X |
0.743 |
|
1989 |
Dynlacht BD, Attardi LD, Admon A, Freeman M, Tjian R. Functional analysis of NTF-1, a developmentally regulated Drosophila transcription factor that binds neuronal cis elements. Genes & Development. 3: 1677-88. PMID 2606344 DOI: 10.1101/Gad.3.11.1677 |
0.346 |
|
1989 |
Glover DM, Alphey L, Axton JM, Cheshire A, Dalby B, Freeman M, Girdham C, Gonzalez C, Karess RE, Leibowitz MH. Mitosis in Drosophila development. Journal of Cell Science. Supplement. 12: 277-91. PMID 2534556 DOI: 10.1242/Jcs.1989.Supplement_12.22 |
0.749 |
|
1987 |
Freeman M, Glover DM. The gnu mutation of Drosophila causes inappropriate DNA synthesis in unfertilized and fertilized eggs. Genes & Development. 1: 924-30. PMID 12465624 |
0.42 |
|
1987 |
Millar SE, Freeman M, Glover DM. The distribution of a 'mitosis-specific' antigen during Drosophila development. Journal of Cell Science. 87: 95-104. PMID 3312250 |
0.463 |
|
1986 |
Freeman M, Nüsslein-Volhard C, Glover DM. The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila. Cell. 46: 457-68. PMID 3089628 DOI: 10.1016/0092-8674(86)90666-5 |
0.513 |
|
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