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Roderick MacKinnon - Publications

Affiliations: 
Rockefeller University, New York, NY, United States 
Area:
Ion channels
Website:
https://www.rockefeller.edu/our-scientists/heads-of-laboratories/872-roderick-mackinnon/
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176 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Mandala VS, MacKinnon R. The membrane electric field regulates the PIP-binding site to gate the KCNQ1 channel. Proceedings of the National Academy of Sciences of the United States of America. 120: e2301985120. PMID 37192161 DOI: 10.1073/pnas.2301985120  0.524
2023 Tao X, Zhao C, MacKinnon R. Membrane protein isolation and structure determination in cell-derived membrane vesicles. Proceedings of the National Academy of Sciences of the United States of America. 120: e2302325120. PMID 37098056 DOI: 10.1073/pnas.2302325120  0.32
2023 Pérez-Mitta G, MacKinnon R. Freestanding lipid bilayer tensiometer for the study of mechanosensitive ion channels. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221541120. PMID 36913590 DOI: 10.1073/pnas.2221541120  0.838
2022 Mandala VS, MacKinnon R. Voltage-sensor movements in the Eag Kv channel under an applied electric field. Proceedings of the National Academy of Sciences of the United States of America. 119: e2214151119. PMID 36331999 DOI: 10.1073/pnas.2214151119  0.547
2022 Zhao C, MacKinnon R. Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron. PMID 36283409 DOI: 10.1016/j.neuron.2022.10.002  0.421
2022 Zhang Y, Tao X, MacKinnon R. Correlation between structure and function in phosphatidylinositol lipid-dependent Kir2.2 gating. Proceedings of the National Academy of Sciences of the United States of America. 119: e2114046119. PMID 35286194 DOI: 10.1073/pnas.2114046119  0.482
2021 Zhao C, MacKinnon R. Molecular structure of an open human K channel. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34815345 DOI: 10.1073/pnas.2112267118  0.562
2021 Niu Y, Tao X, Vaisey G, Olinares PDB, Alwaseem H, Chait BT, MacKinnon R. Analysis of the mechanosensor channel functionality of TACAN. Elife. 10. PMID 34374644 DOI: 10.7554/eLife.71188  0.536
2020 Niu Y, Tao X, Touhara KK, MacKinnon R. Cryo-EM analysis of PIP regulation in mammalian GIRK channels. Elife. 9. PMID 32844743 DOI: 10.7554/eLife.60552  0.568
2020 Niu Y, Tao X, Touhara KK, MacKinnon R. Author response: Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels Elife. DOI: 10.7554/Elife.60552.Sa2  0.543
2019 Sun J, MacKinnon R. Structural Basis of Human KCNQ1 Modulation and Gating. Cell. PMID 31883792 DOI: 10.1016/J.Cell.2019.12.003  0.709
2019 Tao X, MacKinnon R. Molecular structures of the human Slo1 K channel in complex with β4. Elife. 8. PMID 31815672 DOI: 10.7554/eLife.51409  0.348
2019 Lee CH, MacKinnon R. Voltage Sensor Movements during Hyperpolarization in the HCN Channel. Cell. 179: 1582-1589.e7. PMID 31787376 DOI: 10.1016/j.cell.2019.11.006  0.652
2019 Tao X, MacKinnon R. Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology. Elife. 8. PMID 31755864 DOI: 10.7554/eLife.52164  0.566
2019 Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R. The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier. Elife. 8. PMID 31674909 DOI: 10.7554/Elife.50403  0.796
2019 Whicher JR, MacKinnon R. Regulation of Eag1 gating by its intracellular domains. Elife. 8. PMID 31490124 DOI: 10.7554/eLife.49188  0.591
2019 Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S. Force-induced conformational changes in PIEZO1. Nature. PMID 31435018 DOI: 10.1038/s41586-019-1499-2  0.414
2019 Tao X, MacKinnon R. Author response: Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology Elife. DOI: 10.7554/Elife.52164.Sa2  0.541
2019 MacKinnon R, Sukharev S. Decision letter: Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS Elife. DOI: 10.7554/Elife.50486.Sa1  0.49
2019 Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R. Author response: The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier Elife. DOI: 10.7554/Elife.50403.022  0.812
2019 Whicher JR, MacKinnon R. Author response: Regulation of Eag1 gating by its intracellular domains Elife. DOI: 10.7554/Elife.49188.026  0.339
2019 Tao X, MacKinnon R. Molecular structures of the human Slo1 K+channel in complex with beta 4. Elife. 8. DOI: 10.2210/Pdb6V22/Pdb  0.456
2019 Lin Y, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S. Structural Response of the Piezo Channel Upon Application of Force Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1633  0.506
2018 Touhara KK, MacKinnon R. Molecular basis of signaling specificity between GIRK channels and GPCRs. Elife. 7. PMID 30526853 DOI: 10.7554/eLife.42908  0.376
2018 Haselwandter CA, MacKinnon R. Piezo's membrane footprint and its contribution to mechanosensitivity. Elife. 7. PMID 30480546 DOI: 10.7554/eLife.41968  0.548
2018 Del Mármol JI, Touhara KK, Croft G, MacKinnon R. Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells. Elife. 7. PMID 30132757 DOI: 10.7554/eLife.33149  0.355
2018 Park E, MacKinnon R. Structure of the CLC-1 chloride channel from . Elife. 7. PMID 29809153 DOI: 10.7554/Elife.36629  0.681
2018 Lee CH, MacKinnon R. Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. Science (New York, N.Y.). 360: 508-513. PMID 29724949 DOI: 10.1126/science.aas9466  0.622
2018 Touhara KK, MacKinnon R. Author response: Molecular basis of signaling specificity between GIRK channels and GPCRs Elife. DOI: 10.7554/Elife.42908.021  0.493
2018 MacKinnon R. Decision letter: Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs Elife. DOI: 10.7554/Elife.42636.047  0.497
2018 Haselwandter CA, MacKinnon R. Author response: Piezo’s membrane footprint and its contribution to mechanosensitivity Elife. DOI: 10.7554/Elife.41968.019  0.3
2018 Park E, MacKinnon R. Author response: Structure of the CLC-1 chloride channel from Homo sapiens Elife. DOI: 10.7554/Elife.36629.031  0.715
2018 Mármol JId, Touhara KK, Croft G, MacKinnon R. Author response: Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells Elife. DOI: 10.7554/Elife.33149.015  0.473
2017 Lee KPK, Chen J, MacKinnon R. Molecular structure of human KATP in complex with ATP and ADP. Elife. 6. PMID 29286281 DOI: 10.7554/Elife.32481  0.481
2017 Guo YR, MacKinnon R. Structure-based membrane dome mechanism for Piezo mechanosensitivity. Elife. 6. PMID 29231809 DOI: 10.7554/eLife.33660  0.617
2017 Sun J, MacKinnon R. Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome. Cell. 169: 1042-1050.e9. PMID 28575668 DOI: 10.1016/J.Cell.2017.05.019  0.586
2017 Wang W, MacKinnon R. Cryo-EM Structure of the Open Human Ether-à-go-go-Related K(+) Channel hERG. Cell. 169: 422-430.e10. PMID 28431243 DOI: 10.1016/j.cell.2017.03.048  0.561
2017 Hite RK, MacKinnon R. Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel. Cell. 168: 390-399.e11. PMID 28111072 DOI: 10.1016/J.Cell.2016.12.030  0.816
2017 Lee CH, MacKinnon R. Structures of the Human HCN1 Hyperpolarization-Activated Channel. Cell. 168: 111-120.e11. PMID 28086084 DOI: 10.1016/j.cell.2016.12.023  0.672
2017 MacKinnon R. Ligand-Dependent Structural States of a K+Channel Analyzed by Cryo-EM Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.111  0.61
2016 Park E, Campbell EB, MacKinnon R. Structure of a CLC chloride ion channel by cryo-electron microscopy. Nature. PMID 28002411 DOI: 10.1038/Nature20812  0.706
2016 Hite RK, Tao X, MacKinnon R. Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel. Nature. PMID 27974801 DOI: 10.1038/Nature20775  0.786
2016 Tao X, Hite RK, MacKinnon R. Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel. Nature. PMID 27974795 DOI: 10.1038/Nature20608  0.793
2016 Whicher JR, MacKinnon R. Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism. Science (New York, N.Y.). 353: 664-9. PMID 27516594 DOI: 10.1126/science.aaf8070  0.632
2016 Su Z, Brown EC, Wang W, MacKinnon R. Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 27091997 DOI: 10.1073/pnas.1602815113  0.571
2016 Touhara KK, Wang W, MacKinnon R. The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers. Elife. 5. PMID 27074664 DOI: 10.7554/eLife.15750  0.502
2016 Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R. Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels. Elife. 5. PMID 27074662 DOI: 10.7554/Elife.15751  0.664
2016 Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R. Author response: Cooperative regulation by G proteins and Na+ of neuronal GIRK2 K+ channels Elife. DOI: 10.7554/Elife.15751.016  0.698
2015 Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R. Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel. Nature. PMID 26436452 DOI: 10.1038/Nature14958  0.858
2014 Brohawn SG, Campbell EB, MacKinnon R. Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature. 516: 126-30. PMID 25471887 DOI: 10.1038/Nature14013  0.833
2014 Hite RK, Butterwick JA, MacKinnon R. Phosphatidic acid modulation of Kv channel voltage sensor function. Elife. 3. PMID 25285449 DOI: 10.7554/Elife.04366  0.783
2014 Wang W, Whorton MR, MacKinnon R. Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system. Elife. 3: e03671. PMID 25049222 DOI: 10.7554/Elife.03671  0.562
2014 Brohawn SG, Su Z, MacKinnon R. Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 111: 3614-9. PMID 24550493 DOI: 10.1073/Pnas.1320768111  0.833
2014 Hite RK, Butterwick JA, MacKinnon R. Author response: Phosphatidic acid modulation of Kv channel voltage sensor function Elife. DOI: 10.7554/Elife.04366.017  0.775
2014 Wang W, Whorton MR, MacKinnon R. Author response: Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system Elife. DOI: 10.7554/Elife.03671.011  0.493
2013 Whorton MR, MacKinnon R. X-ray structure of the mammalian GIRK2-βγ G-protein complex. Nature. 498: 190-7. PMID 23739333 DOI: 10.1038/Nature12241  0.588
2013 Banerjee A, Lee A, Campbell E, Mackinnon R. Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife. 2: e00594. PMID 23705070 DOI: 10.7554/Elife.00594  0.612
2013 Brohawn SG, Campbell EB, MacKinnon R. Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 110: 2129-34. PMID 23341632 DOI: 10.1073/Pnas.1218950110  0.839
2013 Banerjee A, Lee A, Campbell E, MacKinnon R. Author response: Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel Elife. DOI: 10.7554/Elife.00594.018  0.603
2013 MacKinnon R, Butterwick J, Letts JL. Biophysical Studies of the Voltage-Dependent Proton Channel Biophysical Journal. 104: 34a. DOI: 10.1016/j.bpj.2012.11.226  0.647
2012 Leonetti MD, Yuan P, Hsiung Y, Mackinnon R. Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 109: 19274-9. PMID 23129643 DOI: 10.1073/pnas.1215078109  0.569
2012 Feng L, Campbell EB, MacKinnon R. Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters. Proceedings of the National Academy of Sciences of the United States of America. 109: 11699-704. PMID 22753511 DOI: 10.1073/Pnas.1205764109  0.505
2012 Schmidt D, del Mármol J, MacKinnon R. Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 109: 10352-7. PMID 22675122 DOI: 10.1073/pnas.1204700109  0.667
2012 Brohawn SG, del Mármol J, MacKinnon R. Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science (New York, N.Y.). 335: 436-41. PMID 22282805 DOI: 10.1126/Science.1213808  0.843
2012 Yuan P, Leonetti MD, Hsiung Y, MacKinnon R. Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel. Nature. 481: 94-7. PMID 22139424 DOI: 10.1038/nature10670  0.528
2011 Whorton MR, MacKinnon R. Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. Cell. 147: 199-208. PMID 21962516 DOI: 10.1016/J.Cell.2011.07.046  0.595
2011 Hansen SB, Tao X, MacKinnon R. Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature. 477: 495-8. PMID 21874019 DOI: 10.1038/Nature10370  0.636
2010 Feng L, Campbell EB, Hsiung Y, MacKinnon R. Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle. Science (New York, N.Y.). 330: 635-41. PMID 20929736 DOI: 10.1126/Science.1195230  0.568
2010 Butterwick JA, MacKinnon R. Solution structure and phospholipid interactions of the isolated voltage-sensor domain from KvAP. Journal of Molecular Biology. 403: 591-606. PMID 20851706 DOI: 10.1016/j.jmb.2010.09.012  0.524
2010 Love J, Mancia F, Shapiro L, Punta M, Rost B, Girvin M, Wang DN, Zhou M, Hunt JF, Szyperski T, Gouaux E, MacKinnon R, McDermott A, Honig B, Inouye M, et al. The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins. Journal of Structural and Functional Genomics. 11: 191-9. PMID 20690043 DOI: 10.1007/S10969-010-9094-7  0.404
2010 Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R. Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science (New York, N.Y.). 329: 182-6. PMID 20508092 DOI: 10.1126/Science.1190414  0.722
2010 Tao X, Lee A, Limapichat W, Dougherty DA, MacKinnon R. A gating charge transfer center in voltage sensors. Science (New York, N.Y.). 328: 67-73. PMID 20360102 DOI: 10.1126/Science.1185954  0.481
2010 MacKinnon R. The Structural Basis of Voltage Sensing Biophysical Journal. 98: 754a. DOI: 10.1016/j.bpj.2009.12.4137  0.376
2009 Tao X, Avalos JL, Chen J, MacKinnon R. Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution. Science (New York, N.Y.). 326: 1668-74. PMID 20019282 DOI: 10.1126/Science.1180310  0.64
2009 Endeward B, Butterwick JA, MacKinnon R, Prisner TF. Pulsed electron-electron double-resonance determination of spin-label distances and orientations on the tetrameric potassium ion channel KcsA. Journal of the American Chemical Society. 131: 15246-50. PMID 19919160 DOI: 10.1021/Ja904808N  0.376
2009 Schmidt D, Cross SR, MacKinnon R. A gating model for the archeal voltage-dependent K(+) channel KvAP in DPhPC and POPE:POPG decane lipid bilayers. Journal of Molecular Biology. 390: 902-12. PMID 19481093 DOI: 10.1016/j.jmb.2009.05.062  0.653
2009 Lee SY, Banerjee A, MacKinnon R. Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. Plos Biology. 7: e47. PMID 19260762 DOI: 10.1371/Journal.Pbio.1000047  0.682
2009 Lee SY, Letts JA, MacKinnon R. Functional reconstitution of purified human Hv1 H+ channels. Journal of Molecular Biology. 387: 1055-60. PMID 19233200 DOI: 10.1016/J.Jmb.2009.02.034  0.736
2009 Lee SY, Banerjee A, Mackinnon R. Two separate interfaces between the Voltage sensor and pore are required for the function of Voltage-dependent K+ channels Plos Biology. 7: 0676-0686. DOI: 10.1371/journal.pbio.1000047-S.pdf  0.646
2008 Schmidt D, MacKinnon R. Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America. 105: 19276-81. PMID 19050073 DOI: 10.1073/pnas.0810187105  0.639
2008 Tao X, MacKinnon R. Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers. Journal of Molecular Biology. 382: 24-33. PMID 18638484 DOI: 10.1016/j.jmb.2008.06.085  0.672
2008 Banerjee A, MacKinnon R. Inferred motions of the S3a helix during voltage-dependent K+ channel gating. Journal of Molecular Biology. 381: 569-80. PMID 18632115 DOI: 10.1016/J.Jmb.2008.06.010  0.537
2008 Lee SY, Letts JA, Mackinnon R. Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. Proceedings of the National Academy of Sciences of the United States of America. 105: 7692-5. PMID 18509058 DOI: 10.1073/Pnas.0803277105  0.69
2007 Long SB, Tao X, Campbell EB, MacKinnon R. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature. 450: 376-82. PMID 18004376 DOI: 10.1038/Nature06265  0.782
2007 Nishida M, Cadene M, Chait BT, MacKinnon R. Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. The Embo Journal. 26: 4005-15. PMID 17703190 DOI: 10.1038/Sj.Emboj.7601828  0.635
2007 Lockless SW, Zhou M, MacKinnon R. Structural and thermodynamic properties of selective ion binding in a K+ channel. Plos Biology. 5: e121. PMID 17472437 DOI: 10.1371/Journal.Pbio.0050121  0.808
2006 Schmidt D, Jiang QX, MacKinnon R. Phospholipids and the origin of cationic gating charges in voltage sensors. Nature. 444: 775-9. PMID 17136096 DOI: 10.1038/nature05416  0.71
2006 Valiyaveetil FI, Leonetti M, Muir TW, Mackinnon R. Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Science (New York, N.Y.). 314: 1004-7. PMID 17095703 DOI: 10.1126/Science.1133415  0.571
2006 Valiyaveetil FI, Sekedat M, MacKinnon R, Muir TW. Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel. Journal of the American Chemical Society. 128: 11591-9. PMID 16939283 DOI: 10.1021/Ja0631955  0.502
2005 Gouaux E, Mackinnon R. Principles of selective ion transport in channels and pumps. Science (New York, N.Y.). 310: 1461-5. PMID 16322449 DOI: 10.1126/science.1113666  0.456
2005 Ruta V, Chen J, MacKinnon R. Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel. Cell. 123: 463-75. PMID 16269337 DOI: 10.1016/j.cell.2005.08.041  0.852
2005 Lee SY, Lee A, Chen J, MacKinnon R. Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America. 102: 15441-6. PMID 16223877 DOI: 10.1073/Pnas.0507651102  0.695
2005 Long SB, Campbell EB, Mackinnon R. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science (New York, N.Y.). 309: 897-903. PMID 16002581 DOI: 10.1126/Science.1116269  0.803
2005 Long SB, Campbell EB, Mackinnon R. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science (New York, N.Y.). 309: 903-8. PMID 16002579 DOI: 10.1126/Science.1116270  0.785
2005 Ohndorf UM, MacKinnon R. Construction of a cyclic nucleotide-gated KcsA K+ channel. Journal of Molecular Biology. 350: 857-65. PMID 15979092 DOI: 10.1016/j.jmb.2005.05.050  0.664
2005 Mackinnon R. Structural biology. Membrane protein insertion and stability. Science (New York, N.Y.). 307: 1425-6. PMID 15746418 DOI: 10.1126/science.1110525  0.328
2004 MacKinnon R. Nobel Lecture. Potassium channels and the atomic basis of selective ion conduction. Bioscience Reports. 24: 75-100. PMID 15628664 DOI: 10.1007/s10540-004-7190-2  0.501
2004 Valiyaveetil FI, Sekedat M, Mackinnon R, Muir TW. Glycine as a D-amino acid surrogate in the K(+)-selectivity filter. Proceedings of the National Academy of Sciences of the United States of America. 101: 17045-9. PMID 15563591 DOI: 10.1073/Pnas.0407820101  0.363
2004 Mackinnon R. Structural biology. Voltage sensor meets lipid membrane. Science (New York, N.Y.). 306: 1304-5. PMID 15550651 DOI: 10.1126/science.1105528  0.51
2004 MacKinnon R. Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angewandte Chemie (International Ed. in English). 43: 4265-77. PMID 15368373 DOI: 10.1002/anie.200400662  0.45
2004 Jiang QX, Wang DN, MacKinnon R. Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation. Nature. 430: 806-10. PMID 15306816 DOI: 10.1038/Nature02735  0.773
2004 Ruta V, MacKinnon R. Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry. 43: 10071-9. PMID 15287735 DOI: 10.1021/bi049463y  0.816
2004 Lee SY, MacKinnon R. A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature. 430: 232-5. PMID 15241419 DOI: 10.1038/Nature02632  0.675
2004 Valiyaveetil FI, Sekedat M, Muir TW, MacKinnon R. Semisynthesis of a functional K+ channel. Angewandte Chemie (International Ed. in English). 43: 2504-7. PMID 15127436 DOI: 10.1002/Anie.200453849  0.588
2004 Zhou Y, MacKinnon R. Ion binding affinity in the cavity of the KcsA potassium channel. Biochemistry. 43: 4978-82. PMID 15109256 DOI: 10.1021/bi049876z  0.54
2004 Zhou M, MacKinnon R. A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. Journal of Molecular Biology. 338: 839-46. PMID 15099749 DOI: 10.1016/J.Jmb.2004.03.020  0.523
2003 MacKinnon R. Potassium channels. Febs Letters. 555: 62-5. PMID 14630320 DOI: 10.1016/S0014-5793(03)01104-9  0.594
2003 Zhou Y, MacKinnon R. The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. Journal of Molecular Biology. 333: 965-75. PMID 14583193 DOI: 10.1016/j.jmb.2003.09.022  0.446
2003 Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R. The principle of gating charge movement in a voltage-dependent K+ channel. Nature. 423: 42-8. PMID 12721619 DOI: 10.1038/Nature01581  0.867
2003 Jiang Y, Lee A, Chen J, Ruta V, Cadene M, Chait BT, MacKinnon R. X-ray structure of a voltage-dependent K+ channel. Nature. 423: 33-41. PMID 12721618 DOI: 10.1038/Nature01580  0.878
2003 Dutzler R, Campbell EB, MacKinnon R. Gating the selectivity filter in ClC chloride channels. Science (New York, N.Y.). 300: 108-12. PMID 12649487 DOI: 10.1126/science.1082708  0.617
2003 Ruta V, Jiang Y, Lee A, Chen J, MacKinnon R. Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature. 422: 180-5. PMID 12629550 DOI: 10.1038/Nature01473  0.879
2002 Nishida M, MacKinnon R. Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution. Cell. 111: 957-65. PMID 12507423 DOI: 10.1016/S0092-8674(02)01227-8  0.647
2002 Yifrach O, MacKinnon R. Energetics of pore opening in a voltage-gated K(+) channel. Cell. 111: 231-9. PMID 12408867 DOI: 10.1016/S0092-8674(02)01013-9  0.638
2002 Valiyaveetil FI, Zhou Y, MacKinnon R. Lipids in the structure, folding, and function of the KcsA K+ channel. Biochemistry. 41: 10771-7. PMID 12196015 DOI: 10.1021/bi026215y  0.552
2002 Valiyaveetil FI, MacKinnon R, Muir TW. Semisynthesis and folding of the potassium channel KcsA. Journal of the American Chemical Society. 124: 9113-20. PMID 12149015 DOI: 10.1021/Ja0266722  0.353
2002 Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. The open pore conformation of potassium channels. Nature. 417: 523-6. PMID 12037560 DOI: 10.1038/417523A  0.82
2002 Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. Crystal structure and mechanism of a calcium-gated potassium channel. Nature. 417: 515-22. PMID 12037559 DOI: 10.1038/417515A  0.823
2002 MacKinnon R. Nothing automatic about ion-channel structures. Nature. 416: 261-2. PMID 11907549 DOI: 10.1038/416261b  0.586
2002 Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R. X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature. 415: 287-94. PMID 11796999 DOI: 10.1038/415287A  0.58
2002 Cadene M, Dutzler R, MacKinnon R, Chait BT. Mass spectrometry for the crystallization of the chloride channel Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 107.  0.365
2001 Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R. Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature. 414: 43-8. PMID 11689936 DOI: 10.1038/35102009  0.545
2001 Morais-Cabral JH, Zhou Y, MacKinnon R. Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature. 414: 37-42. PMID 11689935 DOI: 10.1038/35102000  0.422
2001 Zhou M, Morais-Cabral JH, Mann S, MacKinnon R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature. 411: 657-61. PMID 11395760 DOI: 10.1038/35079500  0.712
2001 Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron. 29: 593-601. PMID 11301020 DOI: 10.1016/S0896-6273(01)00236-7  0.822
2000 Gulbis JM, Zhou M, Mann S, MacKinnon R. Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science (New York, N.Y.). 289: 123-7. PMID 10884227 DOI: 10.1126/Science.289.5476.123  0.544
2000 Imredy JP, MacKinnon R. Energetic and structural interactions between delta-dendrotoxin and a voltage-gated potassium channel. Journal of Molecular Biology. 296: 1283-94. PMID 10698633 DOI: 10.1006/jmbi.2000.3522  0.648
2000 Jiang Y, MacKinnon R. The barium site in a potassium channel by x-ray crystallography. The Journal of General Physiology. 115: 269-72. PMID 10694255 DOI: 10.1085/Jgp.115.3.269  0.74
1999 Hille B, Armstrong CM, MacKinnon R. Ion channels: from idea to reality. Nature Medicine. 5: 1105-9. PMID 10502800 DOI: 10.1038/13415  0.584
1999 Gulbis JM, Mann S, MacKinnon R. Structure of a voltage-dependent K+ channel beta subunit. Cell. 97: 943-52. PMID 10399921 DOI: 10.1016/S0092-8674(00)80805-3  0.574
1999 Morrill JA, MacKinnon R. Isolation of a single carboxyl-carboxylate proton binding site in the pore of a cyclic nucleotide-gated channel. The Journal of General Physiology. 114: 71-83. PMID 10398693 DOI: 10.1085/jgp.114.1.71  0.538
1999 Roux B, MacKinnon R. The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations. Science (New York, N.Y.). 285: 100-2. PMID 10390357 DOI: 10.1126/Science.285.5424.100  0.6
1998 Morais Cabral JH, Lee A, Cohen SL, Chait BT, Li M, Mackinnon R. Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell. 95: 649-55. PMID 9845367 DOI: 10.1016/S0092-8674(00)81635-9  0.543
1998 Imredy JP, Chen C, MacKinnon R. A snake toxin inhibitor of inward rectifier potassium channel ROMK1. Biochemistry. 37: 14867-74. PMID 9778362 DOI: 10.1021/bi980929k  0.647
1998 Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (New York, N.Y.). 280: 69-77. PMID 9525859 DOI: 10.1126/Science.280.5360.69  0.763
1998 MacKinnon R, Cohen SL, Kuo A, Lee A, Chait BT. Structural conservation in prokaryotic and eukaryotic potassium channels. Science (New York, N.Y.). 280: 106-9. PMID 9525854 DOI: 10.1126/Science.280.5360.106  0.643
1997 MacKinnon R, Doyle DA. Prokaryotes offer hope for potassium channel structural studies. Nature Structural Biology. 4: 877-9. PMID 9360597 DOI: 10.1038/Nsb1197-877  0.798
1997 Lu Z, MacKinnon R. Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom. Biochemistry. 36: 6936-40. PMID 9188688 DOI: 10.1021/bi9702849  0.624
1997 Swartz KJ, MacKinnon R. Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron. 18: 675-82. PMID 9136775 DOI: 10.1016/S0896-6273(00)80307-4  0.607
1997 Swartz KJ, MacKinnon R. Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites. Neuron. 18: 665-73. PMID 9136774 DOI: 10.1016/S0896-6273(00)80306-2  0.668
1996 Gross A, MacKinnon R. Agitoxin footprinting the shaker potassium channel pore. Neuron. 16: 399-406. PMID 8789954 DOI: 10.1016/S0896-6273(00)80057-4  0.517
1996 Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell. 85: 1067-76. PMID 8674113 DOI: 10.1016/S0092-8674(00)81307-0  0.662
1996 Aggarwal SK, MacKinnon R. Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron. 16: 1169-77. PMID 8663993 DOI: 10.1016/S0896-6273(00)80143-9  0.588
1996 Ranganathan R, Lewis JH, MacKinnon R. Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron. 16: 131-9. PMID 8562077 DOI: 10.1016/S0896-6273(00)80030-6  0.753
1995 Krezel AM, Kasibhatla C, Hidalgo P, MacKinnon R, Wagner G. Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry. Protein Science : a Publication of the Protein Society. 4: 1478-89. PMID 8520473 DOI: 10.1002/pro.5560040805  0.617
1995 Hidalgo P, MacKinnon R. Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science (New York, N.Y.). 268: 307-10. PMID 7716527 DOI: 10.1126/Science.7716527  0.567
1995 Park CS, MacKinnon R. Divalent cation selectivity in a cyclic nucleotide-gated ion channel. Biochemistry. 34: 13328-33. PMID 7577917 DOI: 10.1021/Bi00041A008  0.555
1995 Swartz KJ, MacKinnon R. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron. 15: 941-9. PMID 7576642 DOI: 10.1016/0896-6273(95)90184-1  0.606
1995 Lu Z, MacKinnon R. Probing a potassium channel pore with an engineered protonatable site. Biochemistry. 34: 13133-8. PMID 7548074 DOI: 10.1021/Bi00040A026  0.634
1995 MacKinnon R. Pore loops: an emerging theme in ion channel structure. Neuron. 14: 889-92. PMID 7538310 DOI: 10.1016/0896-6273(95)90327-5  0.587
1994 Garcia ML, Garcia-Calvo M, Hidalgo P, Lee A, MacKinnon R. Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry. 33: 6834-9. PMID 8204618 DOI: 10.1021/Bi00188A012  0.576
1994 Heginbotham L, Lu Z, Abramson T, MacKinnon R. Mutations in the K+ channel signature sequence. Biophysical Journal. 66: 1061-7. PMID 8038378 DOI: 10.1016/S0006-3495(94)80887-2  0.569
1994 Gross A, Abramson T, MacKinnon R. Transfer of the scorpion toxin receptor to an insensitive potassium channel. Neuron. 13: 961-6. PMID 7946339 DOI: 10.1016/0896-6273(94)90261-5  0.634
1994 Lu Z, MacKinnon R. Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel. Nature. 371: 243-6. PMID 7915826 DOI: 10.1038/371243a0  0.627
1994 Lu Z, MacKinnon R. A conductance maximum observed in an inward-rectifier potassium channel. The Journal of General Physiology. 104: 477-86. PMID 7807057 DOI: 10.1085/Jgp.104.3.477  0.611
1994 Root MJ, MacKinnon R. Two identical noninteracting sites in an ion channel revealed by proton transfer. Science (New York, N.Y.). 265: 1852-6. PMID 7522344 DOI: 10.1126/Science.7522344  0.578
1993 Perozo E, MacKinnon R, Bezanilla F, Stefani E. Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels. Neuron. 11: 353-8. PMID 8352943 DOI: 10.1016/0896-6273(93)90190-3  0.669
1993 Heginbotham L, MacKinnon R. Conduction properties of the cloned Shaker K+ channel. Biophysical Journal. 65: 2089-96. PMID 8298038 DOI: 10.1016/S0006-3495(93)81244-X  0.59
1993 MacKinnon R, Aldrich RW, Lee AW. Functional stoichiometry of Shaker potassium channel inactivation. Science (New York, N.Y.). 262: 757-9. PMID 7694359 DOI: 10.1126/Science.7694359  0.591
1993 Root MJ, MacKinnon R. Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel. Neuron. 11: 459-66. PMID 7691102 DOI: 10.1016/0896-6273(93)90150-P  0.624
1993 Escobar L, Root MJ, MacKinnon R. Influence of protein surface charge on the bimolecular kinetics of a potassium channel peptide inhibitor. Biochemistry. 32: 6982-7. PMID 7687466 DOI: 10.1021/Bi00078A024  0.527
1992 Heginbotham L, MacKinnon R. The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron. 8: 483-91. PMID 1550673 DOI: 10.1016/0896-6273(92)90276-J  0.597
1992 Heginbotham L, Abramson T, MacKinnon R. A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels. Science (New York, N.Y.). 258: 1152-5. PMID 1279807 DOI: 10.1126/Science.1279807  0.674
1991 Yellen G, Jurman ME, Abramson T, MacKinnon R. Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science (New York, N.Y.). 251: 939-42. PMID 2000494 DOI: 10.1126/Science.2000494  0.835
1991 MacKinnon R. Using mutagenesis to study potassium channel mechanisms. Journal of Bioenergetics and Biomembranes. 23: 647-63. PMID 1917912 DOI: 10.1007/BF00785815  0.683
1991 MacKinnon R. New insights into the structure and function of potassium channels. Current Opinion in Neurobiology. 1: 14-9. PMID 1822292 DOI: 10.1016/0959-4388(91)90005-R  0.61
1991 MacKinnon R. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature. 350: 232-5. PMID 1706481 DOI: 10.1038/350232a0  0.665
1990 MacKinnon R, Yellen G. Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science (New York, N.Y.). 250: 276-9. PMID 2218530 DOI: 10.1126/Science.2218530  0.852
1990 MacKinnon R, Heginbotham L, Abramson T. Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron. 5: 767-71. PMID 1702643 DOI: 10.1016/0896-6273(90)90335-D  0.65
1990 Schumaker MF, MacKinnon R. A simple model for multi-ion permeation. Single-vacancy conduction in a simple pore model. Biophysical Journal. 58: 975-84. PMID 1701102 DOI: 10.1016/S0006-3495(90)82442-5  0.539
1989 MacKinnon R, Latorre R, Miller C. Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel. Biochemistry. 28: 8092-9. PMID 2605175 DOI: 10.1021/Bi00446A020  0.696
1989 MacKinnon R, Miller C. Functional modification of a Ca2+-activated K+ channel by trimethyloxonium. Biochemistry. 28: 8087-92. PMID 2481495 DOI: 10.1021/Bi00446A019  0.72
1989 MacKinnon R, Miller C. Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science (New York, N.Y.). 245: 1382-5. PMID 2476850 DOI: 10.1126/Science.2476850  0.615
1988 MacKinnon R, Reinhart PH, White MM. Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features. Neuron. 1: 997-1001. PMID 2483094 DOI: 10.1016/0896-6273(88)90156-0  0.723
1988 MacKinnon R, Miller C. Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel. The Journal of General Physiology. 91: 335-49. PMID 2454283 DOI: 10.1085/Jgp.91.3.335  0.561
1988 Anderson CS, MacKinnon R, Smith C, Miller C. Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength. The Journal of General Physiology. 91: 317-33. PMID 2454282 DOI: 10.1085/Jgp.91.3.317  0.659
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