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Boxun Lu - Publications

Affiliations: 
biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
ion channel
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lu J, Pan Y, Feng X, Lu B. Phase transition and lysosomal degradation of expanded CAG repeat RNA suppress global protein synthesis. Autophagy. 1-3. PMID 37876230 DOI: 10.1080/15548627.2023.2274208  0.654
2023 Pan Y, Lu J, Feng X, Lu S, Yang Y, Yang G, Tan S, Wang L, Li P, Luo S, Lu B. Gelation of cytoplasmic expanded CAG RNA repeats suppresses global protein synthesis. Nature Chemical Biology. PMID 37592155 DOI: 10.1038/s41589-023-01384-5  0.656
2022 Long J, Luo X, Fang D, Song H, Fang W, Shan H, Liu P, Lu B, Yin XM, Hong L, Li M. Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington's disease-related phenotype. Cell & Bioscience. 12: 167. PMID 36209136 DOI: 10.1186/s13578-022-00906-3  0.327
2021 Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. Author Correction: A growth-factor-activated lysosomal K channel regulates Parkinson's pathology. Nature. PMID 33790472 DOI: 10.1038/s41586-021-03438-x  0.615
2021 Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. A growth-factor-activated lysosomal K channel regulates Parkinson's pathology. Nature. PMID 33505021 DOI: 10.1038/s41586-021-03185-z  0.658
2021 Li XJ, Zhang YY, Fu YH, Zhang H, Li HX, Li QF, Li HL, Tan RK, Jiang CX, Jiang W, Li ZX, Luo C, Lu BX, Dang YJ. Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex. Acta Pharmacologica Sinica. PMID 33495516 DOI: 10.1038/s41401-020-00605-0  0.311
2020 Ding Y, Fei Y, Lu B. Emerging New Concepts of Degrader Technologies. Trends in Pharmacological Sciences. PMID 32416934 DOI: 10.1016/J.Tips.2020.04.005  0.3
2019 Roberts SL, Evans T, Yang Y, Fu Y, Button RW, Sipthorpe RJ, Cowan K, Valionyte E, Anichtchik O, Li H, Lu B, Luo S. Bim contributes to the progression of Huntington's disease-associated phenotypes. Human Molecular Genetics. PMID 31813995 DOI: 10.1093/hmg/ddz275  0.308
2019 Valionyte E, Yang Y, Roberts SL, Kelly J, Lu B, Luo S. Lowering mutant huntingtin levels and toxicity: autophagy-endolysosome pathways in Huntington's disease. Journal of Molecular Biology. PMID 31786267 DOI: 10.1016/J.Jmb.2019.11.012  0.396
2019 Li Z, Zhu C, Ding Y, Fei Y, Lu B. ATTEC: a potential new approach to target proteinopathies. Autophagy. PMID 31690177 DOI: 10.1080/15548627.2019.1688556  0.415
2019 Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, ... ... Lu B, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. PMID 31666698 DOI: 10.1038/S41586-019-1722-1  0.563
2018 Feng X, Luo S, Lu B. Conformation Polymorphism of Polyglutamine Proteins. Trends in Biochemical Sciences. PMID 29636213 DOI: 10.1016/J.Tibs.2018.03.002  0.673
2018 Song H, Li H, Guo S, Pan Y, Fu Y, Zhou Z, Li Z, Wen X, Sun X, He B, Gu H, Zhao Q, Wang C, An P, Luo S, ... ... Lu B, et al. Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes. Brain : a Journal of Neurology. PMID 29608652 DOI: 10.1093/Brain/Awy081  0.389
2017 Yu M, Fu Y, Liang Y, Song H, Yao Y, Wu P, Yao Y, Pan Y, Wen X, Ma L, Hexige S, Ding Y, Luo S, Lu B. Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models. Cell Research. PMID 29151587 DOI: 10.1038/Cr.2017.113  0.393
2017 Fu Y, Sun X, Lu B. HIPK3 modulates autophagy and HTT protein levels in neuronal and mouse models of Huntington disease. Autophagy. 1-6. PMID 29130397 DOI: 10.1080/15548627.2017.1393130  0.411
2017 Sun X, Fu Y, Pan Y, Lu B. Conformation-dependent Recognition of Mutant HTT (huntingtin) Proteins by Selective Autophagy. Autophagy. 0. PMID 28976800 DOI: 10.1080/15548627.2017.1382783  0.381
2017 Fu Y, Wu P, Pan Y, Sun X, Yang H, Difiglia M, Lu B. A toxic mutant huntingtin species is resistant to selective autophagy. Nature Chemical Biology. PMID 28869595 DOI: 10.1038/Nchembio.2461  0.354
2016 Vodicka P, Chase K, Iuliano M, Valentine DT, Sapp E, Lu B, Kegel-Gleason KB, Sena-Esteves M, Aronin N, DiFiglia M. Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice. Journal of Huntington's Disease. PMID 27314618 DOI: 10.3233/Jhd-160195  0.387
2016 Wu P, Lu MX, Cui XT, Yang HQ, Yu SL, Zhu JB, Sun XL, Lu B. A high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteins. Acta Pharmacologica Sinica. PMID 27264314 DOI: 10.1038/Aps.2016.31  0.395
2015 Yao Y, Cui X, Al-Ramahi I, Sun X, Li B, Hou J, Difiglia M, Palacino J, Wu ZY, Ma L, Botas J, Lu B. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. Elife. 4. PMID 25738228 DOI: 10.7554/Elife.05449  0.419
2014 Cui X, Liang Q, Liang Y, Lu M, Ding Y, Lu B. TR-FRET assays of Huntingtin protein fragments reveal temperature and polyQ length-dependent conformational changes. Scientific Reports. 4: 5601. PMID 24998512 DOI: 10.1038/Srep05601  0.325
2014 Yu S, Liang Y, Palacino J, Difiglia M, Lu B. Drugging unconventional targets: insights from Huntington's disease. Trends in Pharmacological Sciences. 35: 53-62. PMID 24388390 DOI: 10.1016/J.Tips.2013.12.001  0.362
2013 Lu B, Al-Ramahi I, Valencia A, Wang Q, Berenshteyn F, Yang H, Gallego-Flores T, Ichcho S, Lacoste A, Hild M, Difiglia M, Botas J, Palacino J. Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Nature Neuroscience. 16: 562-70. PMID 23525043 DOI: 10.1038/Nn.3367  0.447
2013 Lu B, Palacino J. A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1820-9. PMID 23325320 DOI: 10.1096/Fj.12-219220  0.387
2010 Lu B, Zhang Q, Wang H, Wang Y, Nakayama M, Ren D. Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron. 68: 488-99. PMID 21040849 DOI: 10.1016/J.Neuron.2010.09.014  0.644
2009 Lu B, Su Y, Das S, Wang H, Wang Y, Liu J, Ren D. Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature. 457: 741-4. PMID 19092807 DOI: 10.1038/Nature07579  0.673
2009 Lu B, Su Y, Das S, Wang H, Wang Y, Liu J, Ren D. Regulation of the NALCN Sodium Leak Channel by Neuropeptides Biophysical Journal. 96: 561a. DOI: 10.1016/J.Bpj.2008.12.3682  0.667
2007 Lu B, Su Y, Das S, Liu J, Xia J, Ren D. The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell. 129: 371-83. PMID 17448995 DOI: 10.1016/J.Cell.2007.02.041  0.652
2005 Lu BX, Liu LY, Liao L, Zhang ZH, Mei YA. Inhibition of Na+ channel currents in rat myoblasts by 4-aminopyridine. Toxicology and Applied Pharmacology. 207: 275-82. PMID 16129120 DOI: 10.1016/J.Taap.2005.01.009  0.525
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