| Year |
Citation |
Score |
| 2023 |
Ruis C, Weimann A, Tonkin-Hill G, Pandurangan AP, Matuszewska M, Murray GGR, Lévesque RC, Blundell TL, Floto RA, Parkhill J. Mutational spectra are associated with bacterial niche. Nature Communications. 14: 7091. PMID 37925514 DOI: 10.1038/s41467-023-42916-w |
0.718 |
|
| 2023 |
Satti AT, Siddiqi AR, Maryam A, Chaitanya Vedithi S, Blundell TL. Structure-guided computational insecticide discovery targeting -N-acetyl-D-hexosaminidase of . Journal of Biomolecular Structure & Dynamics. 1-14. PMID 37814544 DOI: 10.1080/07391102.2023.2264394 |
0.764 |
|
| 2023 |
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, et al. PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Science Advances. 9: eadg2834. PMID 37256950 DOI: 10.1126/sciadv.adg2834 |
0.811 |
|
| 2023 |
Dasoondi RS, Blundell TL, Pandurangan AP. analyses of isoniazid and streptomycin resistance-associated mutations in . Computational and Structural Biotechnology Journal. 21: 1874-1884. PMID 36915381 DOI: 10.1016/j.csbj.2023.02.035 |
0.748 |
|
| 2023 |
El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C. Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference. Angewandte Chemie (International Ed. in English). PMID 36757665 DOI: 10.1002/anie.202300221 |
0.692 |
|
| 2023 |
Liang S, Blundell TL. Human DNA-dependent protein kinase activation mechanism. Nature Structural & Molecular Biology. PMID 36604499 DOI: 10.1038/s41594-022-00881-w |
0.796 |
|
| 2022 |
Goff NJ, Brenière M, Buehl CJ, de Melo AJ, Huskova H, Ochi T, Blundell TL, Mao W, Yu K, Modesti M, Meek K. Catalytically inactive DNA ligase IV promotes DNA repair in living cells. Nucleic Acids Research. PMID 36263813 DOI: 10.1093/nar/gkac913 |
0.619 |
|
| 2022 |
Boeck L, Burbaud S, Skwark M, Pearson WH, Sangen J, Wuest AW, Marshall EKP, Weimann A, Everall I, Bryant JM, Malhotra S, Bannerman BP, Kierdorf K, Blundell TL, Dionne MS, et al. Mycobacterium abscessus pathogenesis identified by phenogenomic analyses. Nature Microbiology. 7: 1431-1441. PMID 36008617 DOI: 10.1038/s41564-022-01204-x |
0.792 |
|
| 2022 |
Thomas SE, McCarthy WJ, El Bakali J, Brown KP, Kim SY, Blaszczyk M, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Structural Characterization of Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design. Frontiers in Molecular Biosciences. 9: 880432. PMID 35712348 DOI: 10.3389/fmolb.2022.880432 |
0.752 |
|
| 2022 |
Rodrigues CHM, Pires DEV, Blundell TL, Ascher DB. Structural landscapes of PPI interfaces. Briefings in Bioinformatics. PMID 35656714 DOI: 10.1093/bib/bbac165 |
0.596 |
|
| 2022 |
Beaudoin CA, Pandurangan AP, Kim SY, Hamaia SW, Huang CL, Blundell TL, Vedithi SC, Jackson AP. In silico analysis of mutations near S1/S2 cleavage site in SARS-CoV-2 spike protein reveals increased propensity of glycosylation in Omicron strain. Journal of Medical Virology. PMID 35575289 DOI: 10.1002/jmv.27845 |
0.743 |
|
| 2022 |
Charoensutthivarakul S, Thomas SE, Curran A, Brown KP, Belardinelli JM, Whitehouse AJ, Acebrón-García-de-Eulate M, Sangan J, Gramani SG, Jackson M, Mendes V, Floto RA, Blundell TL, Coyne AG, Abell C. Development of Inhibitors of SAICAR Synthetase (PurC) from Using a Fragment-Based Approach. Acs Infectious Diseases. PMID 35037462 DOI: 10.1021/acsinfecdis.1c00432 |
0.726 |
|
| 2022 |
Liang S, Thomas SE, Chaplin AK, Hardwick SW, Chirgadze DY, Blundell TL. Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Nature. PMID 34987222 DOI: 10.1038/s41586-021-04274-9 |
0.814 |
|
| 2021 |
Chaplin AK, Hardwick SW, Stavridi AK, Buehl CJ, Goff NJ, Ropars V, Liang S, De Oliveira TM, Chirgadze DY, Meek K, Charbonnier JB, Blundell TL. Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Molecular Cell. PMID 34352203 DOI: 10.1016/j.molcel.2021.07.005 |
0.813 |
|
| 2021 |
Jamasb AR, Day B, Cangea C, Liò P, Blundell TL. Deep Learning for Protein-Protein Interaction Site Prediction. Methods in Molecular Biology (Clifton, N.J.). 2361: 263-288. PMID 34236667 DOI: 10.1007/978-1-0716-1641-3_16 |
0.8 |
|
| 2021 |
Beaudoin CA, Jamasb AR, Alsulami AF, Copoiu L, van Tonder AJ, Hala S, Bannerman BP, Thomas SE, Vedithi SC, Torres PHM, Blundell TL. Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses. Computational and Structural Biotechnology Journal. PMID 34234921 DOI: 10.1016/j.csbj.2021.06.041 |
0.811 |
|
| 2021 |
Gupta P, Thomas SE, Zaidan SA, Pasillas MA, Cory-Wright J, Sebastián-Pérez V, Burgess A, Cattermole E, Meghir C, Abell C, Coyne AG, Jacobs WR, Blundell TL, Tiwari S, Mendes V. A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of . Computational and Structural Biotechnology Journal. 19: 3491-3506. PMID 34194673 DOI: 10.1016/j.csbj.2021.06.006 |
0.708 |
|
| 2021 |
Alsulami AF, Torres PHM, Moghul I, Arif SM, Chaplin AK, Vedithi SC, Blundell TL. COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets. Briefings in Bioinformatics. PMID 34137435 DOI: 10.1093/bib/bbab220 |
0.759 |
|
| 2021 |
Vedithi SC, Malhotra S, Acebrón-García-de-Eulate M, Matusevicius M, Torres PHM, Blundell TL. Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of . Frontiers in Molecular Biosciences. 8: 663301. PMID 34026836 DOI: 10.3389/fmolb.2021.663301 |
0.805 |
|
| 2021 |
Torres PHM, Rossi AD, Blundell TL. ProtCHOIR: a tool for proteome-scale generation of homo-oligomers. Briefings in Bioinformatics. PMID 34015821 DOI: 10.1093/bib/bbab182 |
0.806 |
|
| 2021 |
Gaudelet T, Day B, Jamasb AR, Soman J, Regep C, Liu G, Hayter JBR, Vickers R, Roberts C, Tang J, Roblin D, Blundell TL, Bronstein MM, Taylor-King JP. Utilizing graph machine learning within drug discovery and development. Briefings in Bioinformatics. PMID 34013350 DOI: 10.1093/bib/bbab159 |
0.788 |
|
| 2021 |
Bryant JM, Brown KP, Burbaud S, Everall I, Belardinelli JM, Rodriguez-Rincon D, Grogono DM, Peterson CM, Verma D, Evans IE, Ruis C, Weimann A, Arora D, Malhotra S, Bannerman B, ... ... Blundell TL, et al. Stepwise pathogenic evolution of . Science (New York, N.Y.). 372. PMID 33926925 DOI: 10.1126/science.abb8699 |
0.654 |
|
| 2021 |
Acebrón-García-de-Eulate M, Blundell TL, Vedithi SC. Strategies for drug target identification in Mycobacterium leprae. Drug Discovery Today. PMID 33798649 DOI: 10.1016/j.drudis.2021.03.026 |
0.747 |
|
| 2021 |
Scott DE, Francis-Newton NJ, Marsh ME, Coyne AG, Fischer G, Moschetti T, Bayly AR, Sharpe TD, Haas KT, Barber L, Valenzano CR, Srinivasan R, Huggins DJ, Lee M, Emery A, ... ... Blundell TL, et al. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chemical Biology. PMID 33662256 DOI: 10.1016/j.chembiol.2021.02.006 |
0.637 |
|
| 2021 |
Hnízda A, Tesina P, Nguyen TB, Kukačka Z, Kater L, Chaplin A, Beckmann R, Ascher DB, Novák P, Blundell TL. SAP domain forms a flexible part of DNA aperture in Ku70/80. The Febs Journal. PMID 33511782 DOI: 10.1111/febs.15732 |
0.675 |
|
| 2021 |
Munir A, Wilson MT, Hardwick SW, Chirgadze DY, Worrall JAR, Blundell TL, Chaplin AK. Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis. Structure (London, England : 1993). PMID 33444527 DOI: 10.1016/j.str.2020.12.008 |
0.789 |
|
| 2021 |
Alsulami AF, Thomas SE, Jamasb AR, Beaudoin CA, Moghul I, Bannerman B, Copoiu L, Vedithi SC, Torres P, Blundell TL. SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets. Briefings in Bioinformatics. PMID 33416848 DOI: 10.1093/bib/bbaa404 |
0.812 |
|
| 2020 |
Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, et al. Mechanism of efficient double-strand break repair by a long non-coding RNA. Nucleic Acids Research. PMID 33337499 DOI: 10.1093/nar/gkaa1233 |
0.761 |
|
| 2020 |
Vedithi SC, Malhotra S, Skwark MJ, Munir A, Acebrón-García-De-Eulate M, Waman VP, Alsulami A, Ascher DB, Blundell TL. HARP: a database of structural impacts of systematic missense mutations in drug targets of . Computational and Structural Biotechnology Journal. 18: 3692-3704. PMID 33304465 DOI: 10.1016/j.csbj.2020.11.013 |
0.821 |
|
| 2020 |
Liang S, Chaplin AK, Stavridi AK, Appleby R, Hnizda A, Blundell TL. Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM. Progress in Biophysics and Molecular Biology. PMID 33285184 DOI: 10.1016/j.pbiomolbio.2020.11.008 |
0.788 |
|
| 2020 |
Munir A, Vedithi SC, Chaplin AK, Blundell TL. Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance. Frontiers in Genetics. 11: 965. PMID 33101362 DOI: 10.3389/Fgene.2020.00965 |
0.799 |
|
| 2020 |
Chaplin AK, Hardwick SW, Liang S, Kefala Stavridi A, Hnizda A, Cooper LR, De Oliveira TM, Chirgadze DY, Blundell TL. Dimers of DNA-PK create a stage for DNA double-strand break repair. Nature Structural & Molecular Biology. PMID 33077952 DOI: 10.1038/s41594-020-00517-x |
0.798 |
|
| 2020 |
Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, et al. Mechanism of efficient double-strand break repair by a long non-coding RNA. Nucleic Acids Research. PMID 33045735 DOI: 10.1093/nar/gkaa784 |
0.802 |
|
| 2020 |
Sabbah M, Mendes V, Vistal RG, Dias DMG, Záhorszká M, Mikušová K, Korduláková J, Coyne AG, Blundell TL, Abell C. Correction to Fragment-Based Design of InhA Inhibitors. Journal of Medicinal Chemistry. PMID 32697583 DOI: 10.1021/Acs.Jmedchem.0C01187 |
0.4 |
|
| 2020 |
Maryam A, Khalid RR, Vedithi SC, Ece A, Çınaroğlu SS, Siddiqi AR, Blundell TL. Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations. Computational and Structural Biotechnology Journal. 18: 1625-1638. PMID 32670503 DOI: 10.1016/J.Csbj.2020.06.016 |
0.813 |
|
| 2020 |
Waman VP, Blundell TL, Buchan DWA, Gough J, Jones D, Kelley L, Murzin A, Pandurangan AP, Sillitoe I, Sternberg M, Torres P, Orengo C. The Genome3D Consortium for Structural Annotations of Selected Model Organisms. Methods in Molecular Biology (Clifton, N.J.). 2165: 27-67. PMID 32621218 DOI: 10.1007/978-1-0716-0708-4_3 |
0.809 |
|
| 2020 |
Ribeiro JA, Hammer AJS, Libreros-Z Uacute Ntilde Iga GAES, Chavez-Pacheco SM, Tyrakis P, de Oliveira GS, Kirkman T, El Bakali J, Rocco SA, Sforça ML, Parise Filho R, Coyne AG, Blundell TL, Abell C, Dias MVB. Using a fragment-based approach to identify alternative chemical scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 32603583 DOI: 10.1021/Acsinfecdis.0C00263 |
0.802 |
|
| 2020 |
Thomas SE, Whitehouse AJ, Brown K, Burbaud S, Belardinelli JM, Sangen J, Lahiri R, Libardo MDJ, Gupta P, Malhotra S, Boshoff HIM, Jackson M, Abell C, Coyne AG, Blundell TL, et al. Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Research. PMID 32602532 DOI: 10.1093/Nar/Gkaa539 |
0.811 |
|
| 2020 |
Kefala Stavridi A, Appleby R, Liang S, Blundell TL, Chaplin AK. Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining. Essays in Biochemistry. PMID 32579168 DOI: 10.1042/EBC20190092 |
0.816 |
|
| 2020 |
Ochi T, Quarantotti V, Lin H, Jullien J, Rosa E Silva I, Boselli F, Barnabas DD, Johnson CM, McLaughlin SH, Freund SMV, Blackford AN, Kimata Y, Goldstein RE, Jackson SP, Blundell TL, et al. CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions. Structure (London, England : 1993). PMID 32375023 DOI: 10.1016/J.Str.2020.04.010 |
0.664 |
|
| 2020 |
Sabbah M, Mendes V, Vistal RG, Dias DM, Záhorszká M, Mikušová K, Korduláková J, Coyne AG, Blundell TL, Abell C. Fragment-based design of Mycobacterium tuberculosis InhA inhibitors. Journal of Medicinal Chemistry. PMID 32240584 DOI: 10.1021/Acs.Jmedchem.0C00007 |
0.483 |
|
| 2020 |
Curran PR, Radoux C, Smilova MD, Sykes R, Higueruelo A, Bradley A, Marsden BD, Spring DR, Blundell TL, Leach AR, Pitt WR, Cole JC. Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design. Journal of Chemical Information and Modeling. PMID 32207937 DOI: 10.1021/acs.jcim.9b00996 |
0.778 |
|
| 2020 |
Vedithi SC, Rodrigues CHM, Portelli S, Skwark MJ, Das M, Ascher DB, Blundell TL, Malhotra S. Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in . Computational and Structural Biotechnology Journal. 18: 271-286. PMID 32042379 DOI: 10.1016/J.Csbj.2020.01.002 |
0.801 |
|
| 2019 |
Mendes V, Acebrón-García-de-Eulate M, Verma N, Blaszczyk M, Dias MVB, Blundell TL. Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate. Mbio. 10. PMID 31772052 DOI: 10.1128/mBio.02272-19 |
0.691 |
|
| 2019 |
Trapero A, Pacitto A, Chan DS, Abell C, Blundell TL, Ascher DB, Coyne AG. Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH). Bioorganic & Medicinal Chemistry Letters. 126792. PMID 31757668 DOI: 10.1016/J.Bmcl.2019.126792 |
0.792 |
|
| 2019 |
Sillitoe I, Andreeva A, Blundell TL, Buchan DWA, Finn RD, Gough J, Jones D, Kelley LA, Paysan-Lafosse T, Lam SD, Murzin AG, Pandurangan AP, Salazar GA, Skwark MJ, Sternberg MJE, et al. Genome3D: integrating a collaborative data pipeline to expand the depth and breadth of consensus protein structure annotation. Nucleic Acids Research. PMID 31733063 DOI: 10.1093/Nar/Gkz967 |
0.801 |
|
| 2019 |
Pandurangan AP, Blundell TL. Prediction of impacts of mutations on protein structure and interactions: SDM, a statistical approach, and mCSM, using machine learning. Protein Science : a Publication of the Protein Society. PMID 31693276 DOI: 10.1002/pro.3774 |
0.764 |
|
| 2019 |
Skwark MJ, Torres PHM, Copoiu L, Bannerman B, Floto RA, Blundell TL. Mabellini: a genome-wide database for understanding the structural proteome and evaluating prospective antimicrobial targets of the emerging pathogen Mycobacterium abscessus. Database : the Journal of Biological Databases and Curation. 2019. PMID 31681953 DOI: 10.1093/Database/Baz113 |
0.749 |
|
| 2019 |
Copoiu L, Torres PHM, Ascher DB, Blundell TL, Malhotra S. ProCarbDB: a database of carbohydrate-binding proteins. Nucleic Acids Research. PMID 31598690 DOI: 10.1093/Nar/Gkz860 |
0.788 |
|
| 2019 |
Saltzberg DJ, Hepburn M, Pilla KB, Schriemer DC, Lees-Miller SP, Blundell TL, Sali A. SSEThread: Integrative threading of the DNA-PKcs sequence based on data from chemical cross-linking and hydrogen deuterium exchange. Progress in Biophysics and Molecular Biology. PMID 31570166 DOI: 10.1016/J.Pbiomolbio.2019.09.003 |
0.456 |
|
| 2019 |
Chan DS, Hess J, Shaw E, Spry C, Starley R, Dagostin C, Dias MV, Kale R, Mendes V, Blundell TL, Coyne AG, Abell C. Structural Insights into Phosphopantothenoylcysteine Synthetase by Native Ion Mobility-Mass Spectrometry. The Biochemical Journal. PMID 31488574 DOI: 10.1042/Bcj20190318 |
0.796 |
|
| 2019 |
Malhotra S, Alsulami AF, Heiyun Y, Ochoa BM, Jubb H, Forbes S, Blundell TL. Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census. Plos One. 14: e0219935. PMID 31323058 DOI: 10.1371/journal.pone.0219935 |
0.815 |
|
| 2019 |
Munir A, Kumar N, Ramalingam SB, Tamilzhalagan S, Shanmugam SK, Palaniappan AN, Nair D, Priyadarshini P, Natarajan M, Tripathy S, Ranganathan UD, Peacock SJ, Parkhill J, Blundell TL, Malhotra S. Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India. Scientific Reports. 9: 10283. PMID 31311987 DOI: 10.1038/s41598-019-46756-x |
0.815 |
|
| 2019 |
Whitehouse A, Thomas SE, Brown KP, Fanourakis A, Chan D, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG. Development of inhibitors against Mycobacterium abscessus tRNA (m1G37) methyltransferase (TrmD) using fragment-based approaches. Journal of Medicinal Chemistry. PMID 31282680 DOI: 10.1021/Acs.Jmedchem.9B00809 |
0.757 |
|
| 2019 |
Singh V, Pacitto A, Donini S, Ferraris DM, Boros S, Illyés E, Szokol B, Rizzi M, Blundell TL, Ascher DB, Pato J, Mizrahi V. Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH. European Journal of Medicinal Chemistry. 174: 309-329. PMID 31055147 DOI: 10.1016/j.ejmech.2019.04.027 |
0.794 |
|
| 2019 |
Thomas SE, Collins P, James RH, Mendes V, Charoensutthivarakul S, Radoux C, Abell C, Coyne AG, Floto RA, von Delft F, Blundell TL. Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 377: 20180422. PMID 31030650 DOI: 10.1098/Rsta.2018.0422 |
0.78 |
|
| 2019 |
Wu Q, Liang S, Ochi T, Chirgadze DY, Huiskonen JT, Blundell TL. Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways. Progress in Biophysics and Molecular Biology. PMID 31014919 DOI: 10.1016/J.Pbiomolbio.2019.03.007 |
0.787 |
|
| 2019 |
Maryam A, Vedithi SC, Khalid RR, Alsulami AF, Torres PHM, Siddiqi AR, Blundell TL. The Molecular Organization of Human cGMP Specific Phosphodiesterase 6 (PDE6): Structural Implications of Somatic Mutations in Cancer and Retinitis Pigmentosa. Computational and Structural Biotechnology Journal. 17: 378-389. PMID 30962868 DOI: 10.1016/J.Csbj.2019.03.004 |
0.803 |
|
| 2019 |
Waman VP, Vedithi SC, Thomas SE, Bannerman BP, Munir A, Skwark MJ, Malhotra S, Blundell TL. Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery. Emerging Microbes & Infections. 8: 109-118. PMID 30866765 DOI: 10.1080/22221751.2018.1561158 |
0.791 |
|
| 2019 |
Curran P, Radoux C, Smilova M, Higueruelo A, Sykes R, Bradley A, Pitt W, Spring D, Blundell T, Cole J. Hotspots API: a toolkit for the application of fragment hotspot mapping to structure-based drug discovery Acta Crystallographica Section a Foundations and Advances. 75: a225-a225. DOI: 10.1107/S0108767319097782 |
0.322 |
|
| 2018 |
Nishi R, Wijnhoven PWG, Kimura Y, Matsui M, Konietzny R, Wu Q, Nakamura K, Blundell TL, Kessler BM. The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage. Scientific Reports. 8: 17891. PMID 30559450 DOI: 10.1038/s41598-018-36235-0 |
0.339 |
|
| 2018 |
Tiwari S, van Tonder AJ, Vilchèze C, Mendes V, Thomas SE, Malek A, Chen B, Chen M, Kim J, Blundell TL, Parkhill J, Weinrick B, Berney M, Jacobs WR. Arginine-deprivation-induced oxidative damage sterilizes . Proceedings of the National Academy of Sciences of the United States of America. PMID 30143580 DOI: 10.1073/Pnas.1808874115 |
0.7 |
|
| 2018 |
Roca C, Requena C, Sebastián-Pérez V, Malhotra S, Radoux C, Pérez C, Martinez A, Antonio Páez J, Blundell TL, Campillo NE. Identification of new allosteric sites and modulators of AChE through computational and experimental tools. Journal of Enzyme Inhibition and Medicinal Chemistry. 33: 1034-1047. PMID 29873262 DOI: 10.1080/14756366.2018.1476502 |
0.685 |
|
| 2018 |
Vedithi SC, Malhotra S, Das M, Daniel S, Kishore N, George A, Arumugam S, Rajan L, Ebenezer M, Ascher DB, Arnold E, Blundell TL. Publisher Correction: Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae. Scientific Reports. 8: 8250. PMID 29789675 DOI: 10.1038/S41598-018-26451-Z |
0.779 |
|
| 2018 |
Wang JL, Duboc C, Wu Q, Ochi T, Liang S, Tsutakawa SE, Lees-Miller SP, Nadal M, Tainer JA, Blundell TL, Strick TR. Dissection of DNA double-strand-break repair using novel single-molecule forceps. Nature Structural & Molecular Biology. PMID 29786079 DOI: 10.1038/S41594-018-0065-1 |
0.786 |
|
| 2018 |
Vedithi SC, Malhotra S, Das M, Daniel S, Kishore N, George A, Arumugam S, Rajan L, Ebenezer M, Ascher DB, Arnold E, Blundell TL. Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae. Scientific Reports. 8: 5016. PMID 29567948 DOI: 10.1038/S41598-018-23423-1 |
0.799 |
|
| 2018 |
Trapero A, Pacitto A, Singh V, Sabbah M, Coyne AG, Mizrahi V, Blundell TL, Ascher DB, Abell C. A fragment-based approach to targeting inosine-5´-monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 29547284 DOI: 10.1021/Acs.Jmedchem.7B01622 |
0.808 |
|
| 2017 |
Malhotra S, Mugumbate G, Blundell TL, Higueruelo AP. TIBLE: a web-based, freely accessible resource for small-molecule binding data for mycobacterial species. Database : the Journal of Biological Databases and Curation. 2017. PMID 29220433 DOI: 10.1093/database/bax041 |
0.778 |
|
| 2017 |
Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP. Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach. Frontiers in Pharmacology. 8: 681. PMID 29018348 DOI: 10.3389/Fphar.2017.00681 |
0.691 |
|
| 2017 |
Malhotra S, Vedithi SC, Blundell TL. Decoding the similarities and differences among mycobacterial species. Plos Neglected Tropical Diseases. 11: e0005883. PMID 28854187 DOI: 10.1371/Journal.Pntd.0005883 |
0.785 |
|
| 2017 |
Chirgadze DY, Ascher DB, Blundell TL, Sibanda BL. DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage. Methods in Enzymology. 592: 145-157. PMID 28668119 DOI: 10.1016/bs.mie.2017.04.001 |
0.564 |
|
| 2017 |
Thomas SE, Mendes V, Kim SY, Malhotra S, Ochoa-Montaño B, Blaszczyk M, Blundell TL. Structural biology and the design of new therapeutics: from HIV and cancer to mycobacterial infections. Journal of Molecular Biology. PMID 28648615 DOI: 10.1016/j.jmb.2017.06.014 |
0.825 |
|
| 2017 |
Pandurangan AP, Ochoa-Montaño B, Ascher DB, Blundell TL. SDM: a server for predicting effects of mutations on protein stability. Nucleic Acids Research. PMID 28525590 DOI: 10.1093/nar/gkx439 |
0.803 |
|
| 2017 |
Chan DS, Mendes V, Thomas SE, McConnell BN, Matak-Vinković D, Coyne AG, Blundell TL, Abell C. Fragment screening against the EthR-DNA interaction by native mass spectrometry. Angewandte Chemie (International Ed. in English). PMID 28513917 DOI: 10.1002/Anie.201702888 |
0.757 |
|
| 2017 |
Pandurangan AP, Ascher DB, Thomas SE, Blundell TL. Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance. Biochemical Society Transactions. 45: 303-311. PMID 28408471 DOI: 10.1042/BST20160422 |
0.806 |
|
| 2017 |
Nikiforov PO, Blaszczyk M, Surade S, Boshoff HI, Sajid A, Delorme V, Deboosere N, Brodin P, Baulard AR, Barry Rd CE, Blundell TL, Abell C. Fragment-sized EthR inhibitors exhibit exceptionally strong ethionamide boosting effect in whole cell Mycobacterium tuberculosis assays. Acs Chemical Biology. PMID 28314097 DOI: 10.1021/Acschembio.7B00091 |
0.469 |
|
| 2017 |
Shiu-Hin Chan D, Seetoh WG, McConnell BN, Matak-Vinković D, Thomas SE, Mendes V, Blaszczyk M, Coyne AG, Blundell TL, Abell C. Structural insights into the EthR-DNA interaction using native mass spectrometry. Chemical Communications (Cambridge, England). PMID 28287239 DOI: 10.1039/C7Cc00804J |
0.761 |
|
| 2017 |
Sibanda BL, Chirgadze DY, Ascher DB, Blundell TL. DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair. Science (New York, N.Y.). 355: 520-524. PMID 28154079 DOI: 10.1126/science.aak9654 |
0.565 |
|
| 2016 |
Malhotra S, Thomas SE, Ochoa Montano B, Blundell TL. Structure-guided, target-based drug discovery - exploiting genome information from HIV to mycobacterial infections. Postepy Biochemii. 62: 262-272. PMID 28132480 |
0.82 |
|
| 2016 |
Jubb HC, Higueruelo AP, Ochoa-Montaño B, Pitt WR, Ascher DB, Blundell TL. Arpeggio: A web server for calculating and visualising interatomic interactions in protein structures. Journal of Molecular Biology. PMID 27964945 DOI: 10.1016/j.jmb.2016.12.004 |
0.808 |
|
| 2016 |
Jubb HC, Pandurangan AP, Turner MA, Ochoa-Montaño B, Blundell TL, Ascher DB. Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health. Progress in Biophysics and Molecular Biology. PMID 27913149 DOI: 10.1016/j.pbiomolbio.2016.10.002 |
0.818 |
|
| 2016 |
Singh V, Donini S, Pacitto A, Sala C, Hartkoorn RC, Dhar N, Keri G, Ascher DB, Mondésert G, Vocat A, Lupien A, Sommer R, Vermet H, Lagrange S, Buechler J, ... ... Blundell TL, et al. The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis. Acs Infectious Diseases. PMID 27726334 DOI: 10.1021/Acsinfecdis.6B00102 |
0.81 |
|
| 2016 |
Moschetti T, Sharpe T, Fischer G, Marsh ME, Ng H, Morgan M, Scott D, Blundell TL, Venkitaraman A, Skidmore J, Abell C, Hyvönen M. Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51. Journal of Molecular Biology. PMID 27725183 DOI: 10.1016/J.Jmb.2016.10.009 |
0.75 |
|
| 2016 |
Park Y, Pacitto A, Bayliss T, Cleghorn LA, Wang Z, Hartman T, Arora K, Ioerger TR, Sacchettini J, Rizzi M, Donini S, Blundell TL, Ascher DB, Rhee KY, Breda A, et al. Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 27704782 DOI: 10.1021/Acsinfecdis.6B00103 |
0.802 |
|
| 2016 |
Chang HH, Watanabe G, Gerodimos CA, Ochi T, Blundell TL, Jackson SP, Lieber MR. Different DNA End Configurations Dictate Which NHEJ Components are Most Important for Joining Efficiency. The Journal of Biological Chemistry. PMID 27703001 DOI: 10.1074/Jbc.M116.752329 |
0.639 |
|
| 2016 |
Marsh ME, Scott DE, Ehebauer MT, Abell C, Blundell TL, Hyvönen M. ATP half-sites in RadA and RAD51 recombinases bind nucleotides. Febs Open Bio. 6: 372-85. PMID 27419043 DOI: 10.1002/2211-5463.12052 |
0.702 |
|
| 2016 |
Pires DE, Blundell TL, Ascher DB. mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance. Scientific Reports. 6: 29575. PMID 27384129 DOI: 10.1038/srep29575 |
0.813 |
|
| 2016 |
Scott DE, Marsh M, Blundell TL, Abell C, Hyvönen M. Structure Activity Relationship of the Peptide Binding Motif Mediating the RAD51:BRCA2 Protein-Protein Interaction. Febs Letters. PMID 26992456 DOI: 10.1002/1873-3468.12139 |
0.726 |
|
| 2016 |
Nikiforov PO, Surade S, Blaszczyk M, Delorme V, Brodin P, Baulard AR, Blundell TL, Abell C. A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Organic & Biomolecular Chemistry. PMID 26806381 DOI: 10.1039/C5Ob02630J |
0.513 |
|
| 2016 |
Pires DE, Chen J, Blundell TL, Ascher DB. In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity. Scientific Reports. 6: 19848. PMID 26797105 DOI: 10.1038/srep19848 |
0.8 |
|
| 2016 |
Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B, Blundell TL. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Molecular Cell. PMID 26778126 DOI: 10.1016/J.Molcel.2015.12.017 |
0.692 |
|
| 2016 |
Liang S, Esswein SR, Ochi T, Wu Q, Ascher DB, Chirgadze D, Sibanda BL, Blundell TL. Achieving selectivity in space and time with DNA double-strand-break response and repair: molecular stages and scaffolds come with strings attached Structural Chemistry. 28: 161-171. DOI: 10.1007/S11224-016-0841-7 |
0.689 |
|
| 2015 |
Pacitto A, Ascher DB, Wong LH, Blaszczyk BK, Nookala RK, Zhang N, Dokudovskaya S, Levine TP, Blundell TL. Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein. Open Biology. 5. PMID 26631379 DOI: 10.1098/rsob.150174 |
0.794 |
|
| 2015 |
Hung AW, Silvestre HL, Wen S, George GP, Boland J, Blundell TL, Ciulli A, Abell C. Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. Chemmedchem. PMID 26486566 DOI: 10.1002/Cmdc.201500414 |
0.666 |
|
| 2015 |
Metri R, Hariharaputran S, Ramakrishnan G, Anand P, Raghavender US, Ochoa-Montaño B, Higueruelo AP, Sowdhamini R, Chandra NR, Blundell TL, Srinivasan N. SInCRe-structural interactome computational resource for Mycobacterium tuberculosis. Database : the Journal of Biological Databases and Curation. 2015. PMID 26130660 DOI: 10.1093/Database/Bav060 |
0.832 |
|
| 2015 |
Blaszczyk M, Harmer NJ, Chirgadze DY, Ascher DB, Blundell TL. Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors. Progress in Biophysics and Molecular Biology. PMID 25957048 DOI: 10.1016/j.pbiomolbio.2015.04.007 |
0.696 |
|
| 2015 |
Jafri M, Wake NC, Ascher DB, Pires DE, Gentle D, Morris MR, Rattenberry E, Simpson MA, Trembath RC, Weber A, Woodward ER, Donaldson A, Blundell TL, Latif F, Maher ER. Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma. Cancer Discovery. 5: 723-9. PMID 25873077 DOI: 10.1158/2159-8290.CD-14-1096 |
0.766 |
|
| 2015 |
Pires DE, Blundell TL, Ascher DB. pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures. Journal of Medicinal Chemistry. 58: 4066-72. PMID 25860834 DOI: 10.1021/acs.jmedchem.5b00104 |
0.778 |
|
| 2015 |
Ochoa-Montaño B, Mohan N, Blundell TL. CHOPIN: a web resource for the structural and functional proteome of Mycobacterium tuberculosis. Database : the Journal of Biological Databases and Curation. 2015. PMID 25833954 DOI: 10.1093/database/bav026 |
0.348 |
|
| 2015 |
Nemethova M, Radvanszky J, Kadasi L, Ascher DB, Pires DE, Blundell TL, Porfirio B, Mannoni A, Santucci A, Milucci L, Sestini S, Biolcati G, Sorge F, Aurizi C, Aquaron R, et al. Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy. European Journal of Human Genetics : Ejhg. PMID 25804398 DOI: 10.1038/Ejhg.2015.60 |
0.76 |
|
| 2015 |
Murray JE, van der Burg M, IJspeert H, Carroll P, Wu Q, Ochi T, Leitch A, Miller ES, Kysela B, Jawad A, Bottani A, Brancati F, Cappa M, Cormier-Daire V, Deshpande C, ... ... Blundell TL, et al. Mutations in the NHEJ component XRCC4 cause primordial dwarfism. American Journal of Human Genetics. 96: 412-24. PMID 25728776 DOI: 10.1016/J.Ajhg.2015.01.013 |
0.681 |
|
| 2015 |
Wu Q, Jubb H, Blundell TL. Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif. Progress in Biophysics and Molecular Biology. 117: 143-8. PMID 25701377 DOI: 10.1016/J.Pbiomolbio.2015.02.003 |
0.807 |
|
| 2015 |
Usher JL, Ascher DB, Pires DE, Milan AM, Blundell TL, Ranganath LR. Analysis of HGD Gene Mutations in Patients with Alkaptonuria from the United Kingdom: Identification of Novel Mutations. Jimd Reports. PMID 25681086 DOI: 10.1007/8904_2014_380 |
0.781 |
|
| 2015 |
Jubb H, Blundell TL, Ascher DB. Flexibility and small pockets at protein-protein interfaces: New insights into druggability. Progress in Biophysics and Molecular Biology. PMID 25662442 DOI: 10.1016/j.pbiomolbio.2015.01.009 |
0.822 |
|
| 2015 |
Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL, Jackson SP. DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science (New York, N.Y.). 347: 185-8. PMID 25574025 DOI: 10.1126/Science.1261971 |
0.676 |
|
| 2015 |
Scott DE, Coyne AG, Venkitaraman A, Blundell TL, Abell C, Hyvönen M. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases. Chemmedchem. 10: 296-303. PMID 25470112 DOI: 10.1002/Cmdc.201402428 |
0.737 |
|
| 2015 |
Ramakrishnan G, Ochoa-Montaño B, Raghavender US, Mudgal R, Joshi AG, Chandra NR, Sowdhamini R, Blundell TL, Srinivasan N. Enriching the annotation of Mycobacterium tuberculosis H37Rv proteome using remote homology detection approaches: insights into structure and function. Tuberculosis (Edinburgh, Scotland). 95: 14-25. PMID 25467293 DOI: 10.1016/J.Tube.2014.10.009 |
0.798 |
|
| 2015 |
Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DW, Chothia C, Cozzetto D, Dana JM, Filippis I, Gough J, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, Mistry J, et al. Genome3D: exploiting structure to help users understand their sequences. Nucleic Acids Research. 43: D382-6. PMID 25348407 DOI: 10.1093/Nar/Gku973 |
0.571 |
|
| 2015 |
Pires DE, Blundell TL, Ascher DB. Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes. Nucleic Acids Research. 43: D387-91. PMID 25324307 DOI: 10.1093/nar/gku966 |
0.814 |
|
| 2015 |
Howard NI, Dias MV, Peyrot F, Chen L, Schmidt MF, Blundell TL, Abell C. Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis. Chemmedchem. 10: 116-33. PMID 25234229 DOI: 10.1002/Cmdc.201402298 |
0.798 |
|
| 2015 |
Ascher DB, Jubb HC, Pires DEV, Ochi T, Higueruelo A, Blundell TL. Protein-protein interactions: Structures and druggability Nato Science For Peace and Security Series a: Chemistry and Biology. 38: 141-163. DOI: 10.1007/978-94-017-9719-1_12 |
0.811 |
|
| 2014 |
Pitt WR, Montalvão RW, Blundell TL. Polyphony: superposition independent methods for ensemble-based drug discovery. Bmc Bioinformatics. 15: 324. PMID 25265915 DOI: 10.1186/1471-2105-15-324 |
0.814 |
|
| 2014 |
Mageed SN, Cunningham F, Hung AW, Silvestre HL, Wen S, Blundell TL, Abell C, McConkey GA. Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy. Antimicrobial Agents and Chemotherapy. 58: 6345-53. PMID 25049241 DOI: 10.1128/Aac.02640-14 |
0.437 |
|
| 2014 |
Gossage L, Pires DE, Olivera-Nappa Á, Asenjo J, Bycroft M, Blundell TL, Eisen T. An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma. Human Molecular Genetics. 23: 5976-88. PMID 24969085 DOI: 10.1093/Hmg/Ddu321 |
0.74 |
|
| 2014 |
Pires DE, Ascher DB, Blundell TL. DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach. Nucleic Acids Research. 42: W314-9. PMID 24829462 DOI: 10.1093/nar/gku411 |
0.795 |
|
| 2014 |
Webb ME, Yorke BA, Kershaw T, Lovelock S, Lobley CM, Kilkenny ML, Smith AG, Blundell TL, Pearson AR, Abell C. Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase. Acta Crystallographica. Section D, Biological Crystallography. 70: 1166-72. PMID 24699660 DOI: 10.1107/S1399004713034275 |
0.461 |
|
| 2014 |
Ochi T, Wu Q, Blundell TL. The spatial organization of non-homologous end joining: from bridging to end joining. Dna Repair. 17: 98-109. PMID 24636752 DOI: 10.1016/J.Dnarep.2014.02.010 |
0.676 |
|
| 2014 |
Surade S, Ty N, Hengrung N, Lechartier B, Cole ST, Abell C, Blundell TL. A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR. The Biochemical Journal. 458: 387-94. PMID 24313835 DOI: 10.1042/Bj20131127 |
0.498 |
|
| 2014 |
Pires DE, Ascher DB, Blundell TL. mCSM: predicting the effects of mutations in proteins using graph-based signatures. Bioinformatics (Oxford, England). 30: 335-42. PMID 24281696 DOI: 10.1093/bioinformatics/btt691 |
0.8 |
|
| 2014 |
Dias MV, Tyrakis P, Domingues RR, Paes Leme AF, Blundell TL. Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs. Structure (London, England : 1993). 22: 94-103. PMID 24210757 DOI: 10.1016/j.str.2013.09.022 |
0.815 |
|
| 2013 |
Tófoli de Araújo F, Bolanos-Garcia VM, Pereira CT, Sanches M, Oshiro EE, Ferreira RC, Chigardze DY, Barbosa JA, de Souza Ferreira LC, Benedetti CE, Blundell TL, Balan A. Structural and physiological analyses of the alkanesulphonate-binding protein (SsuA) of the citrus pathogen Xanthomonas citri. Plos One. 8: e80083. PMID 24282519 DOI: 10.1371/journal.pone.0080083 |
0.808 |
|
| 2013 |
Silvestre HL, Blundell TL, Abell C, Ciulli A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proceedings of the National Academy of Sciences of the United States of America. 110: 12984-9. PMID 23872845 DOI: 10.1073/Pnas.1304045110 |
0.666 |
|
| 2013 |
Higueruelo AP, Jubb H, Blundell TL. TIMBAL v2: update of a database holding small molecules modulating protein-protein interactions. Database : the Journal of Biological Databases and Curation. 2013: bat039. PMID 23766369 DOI: 10.1093/database/bat039 |
0.809 |
|
| 2013 |
Higueruelo AP, Jubb H, Blundell TL. Protein-protein interactions as druggable targets: recent technological advances. Current Opinion in Pharmacology. 13: 791-6. PMID 23735579 DOI: 10.1016/j.coph.2013.05.009 |
0.808 |
|
| 2013 |
Ochi T, Gu X, Blundell TL. Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair. Structure (London, England : 1993). 21: 672-9. PMID 23523427 DOI: 10.1016/J.Str.2013.02.014 |
0.656 |
|
| 2013 |
Scott DE, Ehebauer MT, Pukala T, Marsh M, Blundell TL, Venkitaraman AR, Abell C, Hyvönen M. Using a fragment-based approach to target protein-protein interactions. Chembiochem : a European Journal of Chemical Biology. 14: 332-42. PMID 23344974 DOI: 10.1002/Cbic.201200521 |
0.745 |
|
| 2013 |
Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DW, Chothia C, Cuff A, Dana JM, Filippis I, Gough J, Hunter S, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, et al. Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains. Nucleic Acids Research. 41: D499-507. PMID 23203986 DOI: 10.1093/Nar/Gks1266 |
0.647 |
|
| 2013 |
Schmidt MF, Korb O, Howard NI, Dias MV, Blundell TL, Abell C. Discovery of Schaeffer's acid analogues as lead structures of mycobacterium tuberculosis type II dehydroquinase using a rational drug design approach. Chemmedchem. 8: 54-8. PMID 23169689 DOI: 10.1002/Cmdc.201200508 |
0.802 |
|
| 2012 |
Higueruelo AP, Schreyer A, Bickerton GR, Blundell TL, Pitt WR. What can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics? Plos One. 7: e51742. PMID 23240060 DOI: 10.1371/journal.pone.0051742 |
0.771 |
|
| 2012 |
Thebault P, Chirgadze DY, Dou Z, Blundell TL, Elowe S, Bolanos-Garcia VM. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). The Biochemical Journal. 448: 321-8. PMID 23067341 DOI: 10.1042/BJ20121448 |
0.665 |
|
| 2012 |
Nookala RK, Langemeyer L, Pacitto A, Ochoa-Montaño B, Donaldson JC, Blaszczyk BK, Chirgadze DY, Barr FA, Bazan JF, Blundell TL. Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Open Biology. 2: 120071. PMID 22977732 DOI: 10.1098/rsob.120071 |
0.795 |
|
| 2012 |
Winter A, Higueruelo AP, Marsh M, Sigurdardottir A, Pitt WR, Blundell TL. Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery. Quarterly Reviews of Biophysics. 45: 383-426. PMID 22971516 DOI: 10.1017/S0033583512000108 |
0.802 |
|
| 2012 |
Bolanos-Garcia VM, Nilsson J, Blundell TL. The architecture of the BubR1 tetratricopeptide tandem repeat defines a protein motif underlying mitotic checkpoint-kinetochore communication. Bioarchitecture. 2: 23-27. PMID 22754625 |
0.656 |
|
| 2012 |
Ochi T, Wu Q, Chirgadze DY, Grossmann JG, Bolanos-Garcia VM, Blundell TL. Structural insights into the role of domain flexibility in human DNA ligase IV. Structure (London, England : 1993). 20: 1212-22. PMID 22658747 DOI: 10.1016/J.Str.2012.04.012 |
0.801 |
|
| 2012 |
Bolanos-Garcia VM, Wu Q, Ochi T, Chirgadze DY, Sibanda BL, Blundell TL. Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 370: 3023-39. PMID 22615474 DOI: 10.1098/Rsta.2011.0268 |
0.779 |
|
| 2012 |
Webb ME, Lobley CM, Soliman F, Kilkenny ML, Smith AG, Blundell TL, Abell C. Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 414-7. PMID 22505409 DOI: 10.1107/S1744309112009487 |
0.484 |
|
| 2012 |
Jubb H, Higueruelo AP, Winter A, Blundell TL. Structural biology and drug discovery for protein-protein interactions. Trends in Pharmacological Sciences. 33: 241-8. PMID 22503442 DOI: 10.1016/j.tips.2012.03.006 |
0.822 |
|
| 2012 |
Surade S, Blundell TL. Structural biology and drug discovery of difficult targets: the limits of ligandability. Chemistry & Biology. 19: 42-50. PMID 22284353 DOI: 10.1016/j.chembiol.2011.12.013 |
0.316 |
|
| 2012 |
Lee S, Thebault P, Freschi L, Beaufils S, Blundell TL, Landry CR, Bolanos-Garcia VM, Elowe S. Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases. The Journal of Biological Chemistry. 287: 5988-6001. PMID 22187426 DOI: 10.1074/Jbc.M111.307355 |
0.753 |
|
| 2012 |
Wu Q, Sibanda L, Ochi T, Bolanos-Garcia VM, Blundell TL, Chirgadze DY. Spatial and temporal organisation of multiprotein systems of cell regulation and signalling: What can we learn from NHEJ system of double-strand break repair? Nato Science For Peace and Security Series a: Chemistry and Biology. 1-31. DOI: 10.1007/978-94-007-2530-0_1 |
0.575 |
|
| 2011 |
Bolanos-Garcia VM, Lischetti T, Matak-Vinković D, Cota E, Simpson PJ, Chirgadze DY, Spring DR, Robinson CV, Nilsson J, Blundell TL. Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site. Structure (London, England : 1993). 19: 1691-700. PMID 22000412 DOI: 10.1016/j.str.2011.09.017 |
0.675 |
|
| 2011 |
Wu Q, Ochi T, Matak-Vinkovic D, Robinson CV, Chirgadze DY, Blundell TL. Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions. Biochemical Society Transactions. 39: 1387-92, suppl 2 p f. PMID 21936820 DOI: 10.1042/Bst0391387 |
0.717 |
|
| 2011 |
Abdel-Rahman N, Martinez-Arias A, Blundell TL. Probing the druggability of protein-protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach. Biochemical Society Transactions. 39: 1327-33. PMID 21936810 DOI: 10.1042/BST0391327 |
0.324 |
|
| 2011 |
Bickerton GR, Higueruelo AP, Blundell TL. Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database. Bmc Bioinformatics. 12: 313. PMID 21801404 DOI: 10.1186/1471-2105-12-313 |
0.78 |
|
| 2011 |
Dias MV, Snee WC, Bromfield KM, Payne RJ, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. The Biochemical Journal. 436: 729-39. PMID 21410435 DOI: 10.1042/Bj20110002 |
0.814 |
|
| 2011 |
Bolanos-Garcia VM, Blundell TL. BUB1 and BUBR1: multifaceted kinases of the cell cycle. Trends in Biochemical Sciences. 36: 141-50. PMID 20888775 DOI: 10.1016/j.tibs.2010.08.004 |
0.646 |
|
| 2010 |
Ochi T, Sibanda BL, Wu Q, Chirgadze DY, Bolanos-Garcia VM, Blundell TL. Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining. Journal of Nucleic Acids. 2010. PMID 20862368 DOI: 10.4061/2010/621695 |
0.78 |
|
| 2010 |
Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL. Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. The Journal of Biological Chemistry. 285: 22495-504. PMID 20430898 DOI: 10.1074/Jbc.M110.107177 |
0.795 |
|
| 2010 |
Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C. Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. Journal of the American Chemical Society. 132: 4544-5. PMID 20232910 DOI: 10.1021/Ja100595U |
0.705 |
|
| 2010 |
D'Arcy S, Davies OR, Blundell TL, Bolanos-Garcia VM. Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition. The Journal of Biological Chemistry. 285: 14764-76. PMID 20220147 DOI: 10.1074/Jbc.M109.082016 |
0.703 |
|
| 2010 |
Sridharan S, Howard N, Kerbarh O, B?aszczyk M, Abell C, Blundell TL. Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes. Journal of Molecular Biology. 397: 290-300. PMID 20079748 DOI: 10.1016/J.Jmb.2010.01.019 |
0.47 |
|
| 2009 |
Blundell TL, Bolanos-Garcia VM. Targeting protein interactions of p53 for therapeutic intervention: success in a frustrated landscape. Cell Cycle (Georgetown, Tex.). 8: 3631-2. PMID 19875920 |
0.639 |
|
| 2009 |
Higueruelo AP, Schreyer A, Bickerton GR, Pitt WR, Groom CR, Blundell TL. Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database. Chemical Biology & Drug Design. 74: 457-67. PMID 19811506 DOI: 10.1111/j.1747-0285.2009.00889.x |
0.78 |
|
| 2009 |
Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angewandte Chemie (International Ed. in English). 48: 8452-6. PMID 19780086 DOI: 10.1002/Anie.200903821 |
0.658 |
|
| 2009 |
Lee S, Brown A, Pitt WR, Higueruelo AP, Gong S, Bickerton GR, Schreyer A, Tanramluk D, Baylay A, Blundell TL. Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics. Molecular Biosystems. 5: 1456-72. PMID 19763326 DOI: 10.1039/B906402H |
0.808 |
|
| 2009 |
Gong S, Worth CL, Bickerton GR, Lee S, Tanramluk D, Blundell TL. Structural and functional restraints in the evolution of protein families and superfamilies. Biochemical Society Transactions. 37: 727-33. PMID 19614584 DOI: 10.1042/Bst0370727 |
0.806 |
|
| 2009 |
Truman AW, Dias MV, Wu S, Blundell TL, Huang F, Spencer JB. Chimeric glycosyltransferases for the generation of hybrid glycopeptides. Chemistry & Biology. 16: 676-85. PMID 19549605 DOI: 10.1016/J.Chembiol.2009.04.013 |
0.789 |
|
| 2009 |
Tanramluk D, Schreyer A, Pitt WR, Blundell TL. On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine. Chemical Biology & Drug Design. 74: 16-24. PMID 19519740 DOI: 10.1111/J.1747-0285.2009.00832.X |
0.783 |
|
| 2009 |
Appert A, Nam CH, Lobato N, Priego E, Miguel RN, Blundell T, Drynan L, Sewell H, Tanaka T, Rabbitts T. Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia. Cancer Research. 69: 4784-90. PMID 19487290 DOI: 10.1158/0008-5472.Can-08-4774 |
0.321 |
|
| 2009 |
Lee S, Blundell TL. Ulla: a program for calculating environment-specific amino acid substitution tables. Bioinformatics (Oxford, England). 25: 1976-7. PMID 19417059 DOI: 10.1093/bioinformatics/btp300 |
0.567 |
|
| 2009 |
Lee S, Blundell TL. BIPA: a database for protein-nucleic acid interaction in 3D structures. Bioinformatics (Oxford, England). 25: 1559-60. PMID 19357098 DOI: 10.1093/bioinformatics/btp243 |
0.646 |
|
| 2009 |
Schreyer A, Blundell T. CREDO: a protein-ligand interaction database for drug discovery. Chemical Biology & Drug Design. 73: 157-67. PMID 19207418 DOI: 10.1111/J.1747-0285.2008.00762.X |
0.439 |
|
| 2009 |
Bolanos-Garcia VM, Kiyomitsu T, D'Arcy S, Chirgadze DY, Grossmann JG, Matak-Vinkovic D, Venkitaraman AR, Yanagida M, Robinson CV, Blundell TL. The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores. Structure (London, England : 1993). 17: 105-16. PMID 19141287 DOI: 10.1016/J.Str.2008.10.015 |
0.676 |
|
| 2009 |
Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen S, Wei AH, Osborne D, Abell C, Blundell TL. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme Nato Science For Peace and Security Series a: Chemistry and Biology. 21-36. DOI: 10.1007/978-90-481-2339-1-3 |
0.442 |
|
| 2009 |
Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen S, Wei AH, Osborne D, Abell C, Blundell TL. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme Nato Science For Peace and Security Series a: Chemistry and Biology. 21-36. |
0.442 |
|
| 2008 |
Montalvao RW, Cavalli A, Salvatella X, Blundell TL, Vendruscolo M. Structure determination of protein-protein complexes using NMR chemical shifts: case of an endonuclease colicin-immunity protein complex. Journal of the American Chemical Society. 130: 15990-6. PMID 18980319 DOI: 10.1021/Ja805258Z |
0.801 |
|
| 2008 |
Cheng TM, Blundell TL, Fernandez-Recio J. Structural assembly of two-domain proteins by rigid-body docking. Bmc Bioinformatics. 9: 441. PMID 18925951 DOI: 10.1186/1471-2105-9-441 |
0.581 |
|
| 2008 |
Ciulli A, Scott DE, Ando M, Reyes F, Saldanha SA, Tuck KL, Chirgadze DY, Blundell TL, Abell C. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem : a European Journal of Chemical Biology. 9: 2606-11. PMID 18821554 DOI: 10.1002/Cbic.200800437 |
0.678 |
|
| 2008 |
Goodger SJ, Robinson CJ, Murphy KJ, Gasiunas N, Harmer NJ, Blundell TL, Pye DA, Gallagher JT. Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms. The Journal of Biological Chemistry. 283: 13001-8. PMID 18281281 DOI: 10.1074/jbc.M704531200 |
0.642 |
|
| 2008 |
Li Y, Chirgadze DY, Bolanos-Garcia VM, Sibanda BL, Davies OR, Ahnesorg P, Jackson SP, Blundell TL. Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ Embo Journal. 27: 290-300. PMID 18046455 DOI: 10.1038/Sj.Emboj.7601942 |
0.695 |
|
| 2008 |
Gore S, Blundell T. Optimal side-chain packing in proteins and crystallographic refinement Journal of Applied Crystallography. 41: 319-328. DOI: 10.1107/S0021889808001672 |
0.316 |
|
| 2007 |
Worth CL, Bickerton GR, Schreyer A, Forman JR, Cheng TM, Lee S, Gong S, Burke DF, Blundell TL. A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease. Journal of Bioinformatics and Computational Biology. 5: 1297-318. PMID 18172930 DOI: 10.1142/S0219720007003120 |
0.647 |
|
| 2007 |
Blundell T. New Dimensions of Structural Proteomics: Exploring Chemical and Biological Space Structure. 15: 1342-1343. PMID 17997956 DOI: 10.1016/J.Str.2007.10.008 |
0.38 |
|
| 2007 |
King JD, Harmer NJ, Preston A, Palmer CM, Rejzek M, Field RA, Blundell TL, Maskell DJ. Predicting Protein Function from Structure-The Roles of Short-chain Dehydrogenase/Reductase Enzymes in Bordetella O-antigen Biosynthesis Journal of Molecular Biology. 374: 749-763. PMID 17950751 DOI: 10.1016/J.Jmb.2007.09.055 |
0.681 |
|
| 2007 |
Harmer NJ, King JD, Palmer CM, Preston A, Maskell DJ, Blundell TL. Cloning, expression, purification and preliminary crystallographic analysis of the short-chain dehydrogenase enzymes WbmF, WbmG and WbmH from Bordetella bronchiseptica Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63: 711-715. PMID 17671375 DOI: 10.1107/S174430910703477X |
0.64 |
|
| 2007 |
Cheng TMK, Blundell TL, Fernandez-Recio J. PyDock: Electrostatics and desolvation for effective scoring of rigid-body protein-protein docking Proteins: Structure, Function and Genetics. 68: 503-515. PMID 17444519 DOI: 10.1002/prot.21419 |
0.588 |
|
| 2007 |
Smith RE, Lovell SC, Burke DF, Montalvao RW, Blundell TL. Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities. Bioinformatics (Oxford, England). 23: 1099-105. PMID 17341496 DOI: 10.1093/bioinformatics/btm073 |
0.772 |
|
| 2007 |
Kerbarh O, Ciulli A, Chirgadze DY, Blundell TL, Abell C. Nucleophile selectivity of chorismate-utilizing enzymes. Chembiochem : a European Journal of Chemical Biology. 8: 622-4. PMID 17335098 DOI: 10.1002/Cbic.200700019 |
0.659 |
|
| 2007 |
Ciulli A, Lobley CM, Tuck KL, Smith AG, Blundell TL, Abell C. pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study. Acta Crystallographica. Section D, Biological Crystallography. 63: 171-8. PMID 17242510 DOI: 10.1107/S0907444906044465 |
0.665 |
|
| 2007 |
Ciulli A, Chirgadze DY, Smith AG, Blundell TL, Abell C. Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: Substrate recognition, conformational change, and cooperativity Journal of Biological Chemistry. 282: 8487-8497. PMID 17229734 DOI: 10.1074/Jbc.M611171200 |
0.683 |
|
| 2007 |
Ciulli A, Blundell TL, Abell C. Discovery and extrapolation of fragment structures towards drug design Rsc Biomolecular Sciences. 293-318. |
0.472 |
|
| 2006 |
Bolanos-Garcia VM, Fernandez-Recio J, Allende JE, Blundell TL. Identifying interaction motifs in CK2beta--a ubiquitous kinase regulatory subunit. Trends in Biochemical Sciences. 31: 654-61. PMID 17084631 DOI: 10.1016/J.Tibs.2006.10.005 |
0.76 |
|
| 2006 |
Blundell TL, Fernández-Recio J. Cell biology: Brief encounters bolster contacts Nature. 444: 279-280. PMID 17051147 DOI: 10.1038/nature05306 |
0.499 |
|
| 2006 |
Ciulli A, Williams G, Smith AG, Blundell TL, Abell C. Probing hot spots at protein-ligand binding sites: A fragment-based approach using biophysical methods Journal of Medicinal Chemistry. 49: 4992-5000. PMID 16884311 DOI: 10.1021/Jm060490R |
0.677 |
|
| 2006 |
Ryu EK, Cho KJ, Kim JK, Harmer NJ, Blundell TL, Kim KH. Expression and purification of recombinant human fibroblast growth factor receptor in Escherichia coli Protein Expression and Purification. 49: 15-22. PMID 16750394 DOI: 10.1016/j.pep.2006.04.008 |
0.619 |
|
| 2006 |
Blundell TL, Sibanda BL, Montalvão RW, Brewerton S, Chelliah V, Worth CL, Harmer NJ, Davies O, Burke D. Structural biology and bioinformatics in drug design: Opportunities and challenges for target identification and lead discovery Philosophical Transactions of the Royal Society B: Biological Sciences. 361: 413-423. PMID 16524830 DOI: 10.1098/Rstb.2005.1800 |
0.825 |
|
| 2006 |
Chelliah V, Blundell TL, Fernández-Recio J. Efficient restraints for protein-protein docking by comparison of observed amino acid substitution patterns with those predicted from local environment Journal of Molecular Biology. 357: 1669-1682. PMID 16488431 DOI: 10.1016/j.jmb.2006.01.001 |
0.609 |
|
| 2006 |
Kerbarh O, Chirgadze DY, Blundell TL, Abell C. Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate Journal of Molecular Biology. 357: 524-534. PMID 16434053 DOI: 10.1016/J.Jmb.2005.12.078 |
0.477 |
|
| 2006 |
Harmer NJ, Robinson CJ, Adam LE, Ilag LL, Robinson CV, Gallagher JT, Blundell TL. Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin. The Biochemical Journal. 393: 741-8. PMID 16223363 DOI: 10.1042/BJ20050985 |
0.629 |
|
| 2005 |
Robinson CJ, Harmer NJ, Goodger SJ, Blundell TL, Gallagher JT. Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes. The Journal of Biological Chemistry. 280: 42274-82. PMID 16219767 DOI: 10.1074/jbc.M505720200 |
0.636 |
|
| 2005 |
Chelliah V, Blundell T, Mizuguchi K. Functional restraints on the patterns of amino acid substitutions: Application to sequence-structure homology recognition Proteins: Structure, Function and Genetics. 61: 722-731. PMID 16193489 DOI: 10.1002/Prot.20617 |
0.336 |
|
| 2005 |
Montalvão RW, Smith RE, Lovell SC, Blundell TL. CHORAL: a differential geometry approach to the prediction of the cores of protein structures. Bioinformatics (Oxford, England). 21: 3719-25. PMID 16046494 DOI: 10.1093/bioinformatics/bti595 |
0.799 |
|
| 2005 |
Lobley CM, Ciulli A, Whitney HM, Williams G, Smith AG, Abell C, Blundell TL. The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. Biochemistry. 44: 8930-9. PMID 15966718 DOI: 10.1021/Bi0502036 |
0.687 |
|
| 2005 |
Messenger NJ, Kabitschke C, Andrews R, Grimmer D, Núñez Miguel R, Blundell TL, Smith JC, Wardle FC. Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1. Developmental Cell. 8: 599-610. PMID 15809041 DOI: 10.1016/J.Devcel.2005.03.001 |
0.344 |
|
| 2005 |
Harmer NJ, Sivak JM, Amaya E, Blundell TL. 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family. Febs Letters. 579: 1161-6. PMID 15710406 DOI: 10.1016/j.febslet.2004.11.114 |
0.68 |
|
| 2005 |
Baker EN, Blundell TL, Vijayan M, Dodson E, Gilliland GL, Sussman JL. Deposition of macromolecular data. Acta Crystallographica. Section D, Biological Crystallography. 52: 609. PMID 15299695 DOI: 10.1107/S0907444996000388 |
0.376 |
|
| 2004 |
Bertrand L, Sayed MF, Pei XY, Parisini E, Dhanaraj V, Bolanos-Garcia VM, Allende JE, Blundell TL. Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop. Acta Crystallographica. Section D, Biological Crystallography. 60: 1698-704. PMID 15388915 DOI: 10.1107/S0907444904016750 |
0.81 |
|
| 2004 |
Chelliah V, Chen L, Blundell TL, Lovell SC. Distinguishing structural and functional restraints in evolution in order to identify interaction sites Journal of Molecular Biology. 342: 1487-1504. PMID 15364576 DOI: 10.1016/j.jmb.2004.08.022 |
0.306 |
|
| 2004 |
Harmer NJ, Ilag LL, Mulloy B, Pellegrini L, Robinson CV, Blundell TL. Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex Journal of Molecular Biology. 339: 821-834. PMID 15165853 DOI: 10.1016/j.jmb.2004.04.031 |
0.659 |
|
| 2004 |
Harmer NJ, Pellegrini L, Chirgadze D, Fernandez-Recio J, Blundell TL. The Crystal Structure of Fibroblast Growth Factor (FGF) 19 Reveals Novel Features of the FGF Family and Offers a Structural Basis for Its Unusual Receptor Affinity Biochemistry. 43: 629-640. PMID 14730967 DOI: 10.1021/bi035320k |
0.788 |
|
| 2004 |
Ottenhof HH, Ashurst JL, Whitney HM, Saldanha SA, Schmitzberger F, Gweon HS, Blundell TL, Abell C, Smith AG. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. The Plant Journal : For Cell and Molecular Biology. 37: 61-72. PMID 14675432 DOI: 10.1046/J.1365-313X.2003.01940.X |
0.459 |
|
| 2003 |
Gherardi E, Youles ME, Miguel RN, Blundell TL, Iamele L, Gough J, Bandyopadhyay A, Hartmann G, Butler PJG. Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor Proceedings of the National Academy of Sciences of the United States of America. 100: 12039-12044. PMID 14528000 DOI: 10.1073/pnas.2034936100 |
0.584 |
|
| 2003 |
Shin DS, Pellegrini L, Daniels DS, Yelent B, Craig L, Bates D, Yu DS, Shivji MK, Hitomi C, Arvai AS, Volkmann N, Tsuruta H, Blundell TL, Venkitaraman AR, Tainer JA. Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. The Embo Journal. 22: 4566-76. PMID 12941707 DOI: 10.1093/Emboj/Cdg429 |
0.307 |
|
| 2003 |
Von Delft F, Inoue T, Saldanha SA, Ottenhof HH, Schmitzberger F, Birch LM, Dhanaraj V, Witty M, Smith AG, Blundell TL, Abell C. Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites Structure. 11: 985-996. PMID 12906829 DOI: 10.1016/S0969-2126(03)00158-8 |
0.491 |
|
| 2003 |
Schmitzberger F, Smith AG, Abell C, Blundell TL. Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms that it is a member of the (βα)8 phosphoenolpyruvate/pyruvate superfamily Journal of Bacteriology. 185: 4163-4171. PMID 12837791 DOI: 10.1128/Jb.185.14.4163-4171.2003 |
0.471 |
|
| 2003 |
Lobley CM, Schmitzberger F, Kilkenny ML, Whitney H, Ottenhof HH, Chakauya E, Webb ME, Birch LM, Tuck KL, Abell C, Smith AG, Blundell TL. Structural insights into the evolution of the pantothenate-biosynthesis pathway. Biochemical Society Transactions. 31: 563-71. PMID 12773157 DOI: 10.1042/Bst0310563 |
0.457 |
|
| 2003 |
Harmer NJ, Chirgadze D, Hyun Kim K, Pellegrini L, Blundell TL. The structural biology of growth factor receptor activation. Biophysical Chemistry. 100: 545-53. PMID 12646390 DOI: 10.1016/S0301-4622(02)00305-8 |
0.775 |
|
| 2002 |
Blundell TL, Jhoti H, Abell C. High-throughput crystallography for lead discovery in drug design. Nature Reviews. Drug Discovery. 1: 45-54. PMID 12119609 DOI: 10.1038/Nrd706 |
0.515 |
|
| 2002 |
Matak-Vinković D, Vinković M, Saldanha SA, Ashurst JL, von Delft F, Inoue T, Miguel RN, Smith AG, Blundell TL, Abell C. Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism. Biochemistry. 40: 14493-500. PMID 11724562 DOI: 10.1021/Bi011020W |
0.495 |
|
| 2001 |
Himpel S, Panzer P, Eirmbter K, Czajkowska H, Sayed M, Packman LC, Blundell T, Kentrup H, Grötzinger J, Joost H, Becker W. Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A. Biochemical Journal. 359: 497-505. PMID 11672423 DOI: 10.1042/0264-6021:3590497 |
0.317 |
|
| 2001 |
von Delft F, Lewendon A, Dhanaraj V, Blundell TL, Abell C, Smith AG. The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily. Structure (London, England : 1993). 9: 439-50. PMID 11377204 DOI: 10.1016/S0969-2126(01)00604-9 |
0.411 |
|
| 1999 |
Nagarajaram HA, Reddy BV, Blundell TL. Analysis and prediction of inter-strand packing distances between beta-sheets of globular proteins. Protein Engineering. 12: 1055-62. PMID 10611399 DOI: 10.1093/Protein/12.12.1055 |
0.605 |
|
| 1999 |
Burke DF, Deane CM, Nagarajaram HA, Campillo N, Martin-Martinez M, Mendes J, Molina F, Perry J, Reddy BV, Soares CM, Steward RE, Williams M, Carrondo MA, Blundell TL, Mizuguchi K. An iterative structure-assisted approach to sequence alignment and comparative modeling. Proteins. 55-60. PMID 10526352 DOI: 10.1002/(Sici)1097-0134(1999)37:3+<55::Aid-Prot8>3.0.Co;2-B |
0.63 |
|
| 1999 |
Walker AR, Davison PA, Bolognesi-Winfield AC, James CM, Srinivasan N, Blundell TL, Esch JJ, Marks MD, Gray JC. The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein. The Plant Cell. 11: 1337-50. PMID 10402433 DOI: 10.1105/Tpc.11.7.1337 |
0.5 |
|
| 1999 |
Srinivasan N, Antonelli M, Jacob G, Korn I, Romero F, Jedlicki A, Dhanaraj V, Sayed MF, Blundell TL, Allende CC, Allende JE. Structural interpretation of site-directed mutagenesis and specificity of the catalytic subunit of protein kinase CK2 using comparative modelling. Protein Engineering. 12: 119-27. PMID 10195283 DOI: 10.1093/Protein/12.2.119 |
0.506 |
|
| 1999 |
Reddy BV, Nagarajaram HA, Blundell TL. Analysis of interactive packing of secondary structural elements in alpha/beta units in proteins. Protein Science : a Publication of the Protein Society. 8: 573-86. PMID 10091660 DOI: 10.1110/ps.8.3.573 |
0.586 |
|
| 1998 |
Sowdhamini R, Burke DF, Deane C, Huang JF, Mizuguchi K, Nagarajaram HA, Overington JP, Srinivasan N, Steward RE, Blundell TL. Protein three-dimensional structural databases: domains, structurally aligned homologues and superfamilies. Acta Crystallographica. Section D, Biological Crystallography. 54: 1168-77. PMID 10089493 DOI: 10.1107/S0907444998007148 |
0.717 |
|
| 1998 |
Mizuguchi K, Deane CM, Blundell TL, Overington JP. HOMSTRAD: a database of protein structure alignments for homologous families. Protein Science : a Publication of the Protein Society. 7: 2469-71. PMID 9828015 DOI: 10.1002/pro.5560071126 |
0.608 |
|
| 1998 |
Sowdhamini R, Burke DF, Huang JF, Mizuguchi K, Nagarajaram HA, Srinivasan N, Steward RE, Blundell TL. CAMPASS: a database of structurally aligned protein superfamilies. Structure (London, England : 1993). 6: 1087-94. PMID 9753697 DOI: 10.1016/S0969-2126(98)00110-5 |
0.468 |
|
| 1998 |
Mizuguchi K, Deane CM, Blundell TL, Johnson MS, Overington JP. JOY: protein sequence-structure representation and analysis. Bioinformatics (Oxford, England). 14: 617-23. PMID 9730927 DOI: 10.1093/bioinformatics/14.7.617 |
0.594 |
|
| 1997 |
Bax B, Blundell TL, Murray-Rust J, McDonald NQ. Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure (London, England : 1993). 5: 1275-85. PMID 9351801 DOI: 10.1016/S0969-2126(97)00280-3 |
0.515 |
|
| 1997 |
Topham CM, Srinivasan N, Blundell TL. Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables. Protein Engineering. 10: 7-21. PMID 9051729 DOI: 10.1093/Protein/10.1.7 |
0.516 |
|
| 1996 |
Blundell TL, Srinivasan N. Symmetry, stability, and dynamics of multidomain and multicomponent protein systems Proceedings of the National Academy of Sciences of the United States of America. 93: 14243-14248. PMID 8962033 DOI: 10.1073/Pnas.93.25.14243 |
0.512 |
|
| 1996 |
Srinivasan N, Bax B, Blundell TL, Parker PJ. Structural aspects of the functional modules in human protein kinase- Cα deduced from comparative analyses Proteins: Structure, Function and Genetics. 26: 217-235. PMID 8916229 DOI: 10.1002/(Sici)1097-0134(199610)26:2<217::Aid-Prot11>3.0.Co;2-S |
0.541 |
|
| 1996 |
Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GL, Sussman JL. Archival journal requirements of macromolecular crystallographic data Journal of Biomolecular Structure & Dynamics. 13: 583. PMID 8906878 DOI: 10.1080/07391102.1996.10508870 |
0.37 |
|
| 1996 |
Baker EN, Blundell TL, Dodson E, Dodson G, Gilliland GL, Sussman JL, Vijayan M. Diffraction data deposition Structure (London, England : 1993). 4: 217. PMID 8805528 DOI: 10.1016/S0969-2126(96)00024-X |
0.434 |
|
| 1996 |
Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GL, Sussman JL. Archival journal requirements for data deposition. Biophysical Journal. 70: 2994. PMID 8744337 DOI: 10.1016/S0006-3495(96)79869-7 |
0.337 |
|
| 1996 |
Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GI, Sussman JL. Crystallographic data deposition Nature. 379: 202. PMID 8538780 DOI: 10.1038/379202A0 |
0.335 |
|
| 1996 |
Introna M, Alles V, Castellano M, Picardi G, De Gioia L, Bottazzai B, Peri G, Breviario F, Salmona M, De Gregorio L, Dragani T, Srinivasan N, Blundell T, Hamilton T, Mantovani A. Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites Blood. 87: 1862-1872. DOI: 10.1182/Blood.V87.5.1862.Bloodjournal8751862 |
0.543 |
|
| 1995 |
Srinivasan N, White HE, Emsley J, Wood SP, Pepys MB, Blundell TL. Comparative analyses of pentraxins: implications for protomer assembly and ligand binding. Structure (London, England : 1993). 2: 1017-27. PMID 7881902 DOI: 10.1016/S0969-2126(94)00105-7 |
0.483 |
|
| 1995 |
May AC, Johnson MS, Rufino SD, Wako H, Zhu ZY, Sowdhamini R, Srinivasan N, Rodionov MA, Blundell TL. The recognition of protein structure and function from sequence: adding value to genome data. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 344: 373-81. PMID 7800707 DOI: 10.1098/Rstb.1994.0076 |
0.537 |
|
| 1995 |
McDonald NQ, Murray-Rust J, Blundell TL. The first structure of a receptor tyrosine kinase domain: a further step in understanding the molecular basis of insulin action. Structure (London, England : 1993). 3: 1-6. PMID 7743124 DOI: 10.1016/S0969-2126(01)00129-0 |
0.554 |
|
| 1995 |
Rao-Naik C, Guruprasad K, Batley B, Rapundalo S, Hill J, Blundell T, Kay J, Dunn BM. Exploring the binding preferences/specificity in the active site of human cathepsin E Proteins: Structure, Function and Genetics. 22: 168-181. PMID 7567964 DOI: 10.1002/Prot.340220209 |
0.319 |
|
| 1995 |
Sowdhamini R, Srinivasan N, Guruprasad K, Rufino S, Dhanaraj V, Wood S, Emsley J, White H, Blundell T. Protein three-dimensional structure and molecular recognition: a story of soft locks and keys Pharmaceutica Acta Helvetiae. 69: 185-192. DOI: 10.1016/0031-6865(95)00002-Q |
0.608 |
|
| 1994 |
Sali A, Blundell TL. Comparative protein modelling by satisfaction of spatial restraints. Journal of Molecular Biology. 234: 779-815. PMID 8254673 DOI: 10.1006/Jmbi.1993.1626 |
0.473 |
|
| 1994 |
Johnson MS, Srinivasan N, Sowdhamini R, Blundell TL. Knowledge-based protein modeling. Critical Reviews in Biochemistry and Molecular Biology. 29: 1-68. PMID 8143488 DOI: 10.3109/10409239409086797 |
0.543 |
|
| 1994 |
Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP. Structure of pentameric human serum amyloid P component. Nature. 367: 338-45. PMID 8114934 DOI: 10.1038/367338A0 |
0.49 |
|
| 1994 |
Donnelly D, Overington JP, Blundell TL. The prediction and orientation of alpha-helices from sequence alignments: the combined use of environment-dependent substitution tables, Fourier transform methods and helix capping rules. Protein Engineering. 7: 645-53. PMID 8073034 |
0.569 |
|
| 1994 |
Narasimhan L, Singh J, Humblet C, Guruprasad K, Blundell T. Snail and spider toxins share a similar tertiary structure and 'cystine motif'. Nature Structural & Molecular Biology. 1: 850-852. PMID 7773771 DOI: 10.1038/Nsb1294-850 |
0.349 |
|
| 1994 |
Bradshaw RA, Murray-Rust J, Ibáñez CF, McDonald NQ, Lapatto R, Blundell TL. Nerve growth factor: structure/function relationships. Protein Science : a Publication of the Protein Society. 3: 1901-13. PMID 7703837 DOI: 10.1002/Pro.5560031102 |
0.569 |
|
| 1994 |
Timm D, Salim K, Gout I, Guruprasad L, Waterfield M, Blundell T. Crystal structure of the pleckstrin homology domain from dynamin. Nature Structural & Molecular Biology. 1: 782-788. PMID 7634088 DOI: 10.1038/Nsb1194-782 |
0.326 |
|
| 1993 |
Johnson MS, Overington JP, Blundell TL. Alignment and searching for common protein folds using a data bank of structural templates. Journal of Molecular Biology. 231: 735-52. PMID 8515448 DOI: 10.1006/jmbi.1993.1323 |
0.618 |
|
| 1993 |
Bradshaw RA, Blundell TL, Lapatto R, McDonald NQ, Murray-Rust J. Nerve growth factor revisited. Trends in Biochemical Sciences. 18: 48-52. PMID 8488558 DOI: 10.1016/0968-0004(93)90052-O |
0.517 |
|
| 1993 |
Donnelly D, Overington JP, Ruffle SV, Nugent JH, Blundell TL. Modeling alpha-helical transmembrane domains: the calculation and use of substitution tables for lipid-facing residues. Protein Science : a Publication of the Protein Society. 2: 55-70. PMID 8443590 DOI: 10.1002/pro.5560020106 |
0.575 |
|
| 1993 |
Topham CM, McLeod A, Eisenmenger F, Overington JP, Johnson MS, Blundell TL. Fragment ranking in modelling of protein structure. Conformationally constrained environmental amino acid substitution tables. Journal of Molecular Biology. 229: 194-220. PMID 8421300 DOI: 10.1006/jmbi.1993.1018 |
0.601 |
|
| 1993 |
Srinivasan N, Blundell TL. An evaluation of the performance of an automated procedure for comparative modelling of protein tertiary structure Protein Engineering, Design and Selection. 6: 501-512. PMID 8415577 DOI: 10.1093/Protein/6.5.501 |
0.527 |
|
| 1993 |
Reddy BV, Blundell TL. Packing of secondary structural elements in proteins. Analysis and prediction of inter-helix distances. Journal of Molecular Biology. 233: 464-79. PMID 8411156 DOI: 10.1006/Jmbi.1993.1524 |
0.626 |
|
| 1993 |
Hoffrén AM, Saloheimo M, Thomas P, Overington JP, Johnson MS, Knowles JK, Blundell TL. Modelling of the lignin peroxidase LIII of Phlebia radiata: use of a sequence template generated from a 3-D structure. Protein Engineering. 6: 177-82. PMID 8386362 |
0.591 |
|
| 1993 |
Overington JP, Zhu ZY, Sali A, Johnson MS, Sowdhamini R, Louie GV, Blundell TL. Molecular recognition in protein families: a database of aligned three-dimensional structures of related proteins. Biochemical Society Transactions. 21: 597-604. PMID 8224474 DOI: 10.1042/Bst0210597 |
0.677 |
|
| 1993 |
Murray-Rust J, McDonald NQ, Blundell TL, Hosang M, Oefner C, Winkler F, Bradshaw RA. Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors. Structure (London, England : 1993). 1: 153-9. PMID 8069627 DOI: 10.1016/0969-2126(93)90029-G |
0.547 |
|
| 1993 |
Blundell T, Hubbard R, Weiss MA. Structural biology and diabetes mellitus: molecular pathogenesis and rational drug design. Diabetologia. S69-76. PMID 1335936 DOI: 10.1007/Bf00586281 |
0.317 |
|
| 1992 |
Zhu ZY, Sali A, Blundell TL. A variable gap penalty function and feature weights for protein 3-D structure comparisons. Protein Engineering. 5: 43-51. PMID 1631045 DOI: 10.1093/Protein/5.1.43 |
0.47 |
|
| 1992 |
Sali A, Veerapandian B, Cooper JB, Moss DS, Hofmann T, Blundell TL. Domain flexibility in aspartic proteinases. Proteins. 12: 158-70. PMID 1603805 DOI: 10.1002/Prot.340120209 |
0.471 |
|
| 1992 |
Overington J, Donnelly D, Johnson MS, Sali A, Blundell TL. Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds. Protein Science : a Publication of the Protein Society. 1: 216-26. PMID 1304904 DOI: 10.1002/Pro.5560010203 |
0.691 |
|
| 1992 |
Blundell T. Macromolecules and medicine Nature. 360: 218-219. DOI: 10.1038/360218A0 |
0.313 |
|
| 1991 |
Pearl L, Blundell T. The active site of aspartic proteinases Febs Letters. 174: 96-101. PMID 6381096 DOI: 10.1016/0014-5793(84)81085-6 |
0.323 |
|
| 1991 |
McDonald NQ, Blundell TL. Crystallization and characterization of the high molecular weight form of nerve growth factor (7 S NGF). Journal of Molecular Biology. 219: 595-601. PMID 2056528 DOI: 10.1016/0022-2836(91)90655-P |
0.507 |
|
| 1991 |
McDonald NQ, Lapatto R, Murray-Rust J, Gunning J, Wlodawer A, Blundell TL. New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature. 354: 411-4. PMID 1956407 DOI: 10.1038/354411A0 |
0.563 |
|
| 1991 |
Hoffrén A, Saloheimo M, Thomas P, Overington J, Johnson M, Blundell T. Modelling the lignin peroxidase LIII of Phlebia radiata using a knowledge-based approach Journal De Chimie Physique. 88: 2659-2662. DOI: 10.1063/1.41321 |
0.623 |
|
| 1990 |
McDonald N, Murray-Rust J, Blundell T. Structure-function relationships of growth factors and their receptors. British Medical Bulletin. 45: 554-69. PMID 2557120 DOI: 10.1093/Oxfordjournals.Bmb.A072342 |
0.3 |
|
| 1990 |
Sali A, Overington JP, Johnson MS, Blundell TL. From comparisons of protein sequences and structures to protein modelling and design. Trends in Biochemical Sciences. 15: 235-40. PMID 2200167 DOI: 10.1016/0968-0004(90)90036-B |
0.688 |
|
| 1990 |
Johnson MS, Sali A, Blundell TL. Phylogenetic relationships from three-dimensional protein structures. Methods in Enzymology. 183: 670-90. PMID 2156133 DOI: 10.1016/0076-6879(90)83044-A |
0.492 |
|
| 1990 |
Topham CM, Thomas P, Overington JP, Johnson MS, Eisenmenger F, Blundell TL. An assessment of COMPOSER: a rule-based approach to modelling protein structure. Biochemical Society Symposium. 57: 1-9. PMID 2099735 |
0.587 |
|
| 1990 |
McDonald NQ, Lapatto R, Murray-Rust J, Blundell TL. X-ray crystallographic studies on murine nerve growth factor. Journal of Cell Science. Supplement. 13: 19-30. PMID 2084116 |
0.538 |
|
| 1990 |
Overington J, Johnson MS, Sali A, Blundell TL. Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction. Proceedings. Biological Sciences / the Royal Society. 241: 132-45. PMID 1978340 DOI: 10.1098/Rspb.1990.0077 |
0.687 |
|
| 1989 |
Sutcliffe MJ, Haneef I, Carney D, Blundell TL. Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures. Protein Engineering. 1: 377-84. PMID 3508286 DOI: 10.1093/PROTEIN/1.5.377 |
0.318 |
|
| 1989 |
Lapatto R, Blundell T, Hemmings A, Overington J, Wilderspin A, Wood S, Merson JR, Whittle PJ, Danley DE, Geoghegan KF. X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes. Nature. 342: 299-302. PMID 2682266 DOI: 10.1038/342299A0 |
0.596 |
|
| 1989 |
Blundell TL, Elliott G, Gardner SP, Hubbard T, Islam S, Johnson M, Mantafounis D, Murray-Rust P, Overington J, Pitts JE. Protein engineering and design. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 324: 447-60. PMID 2573083 DOI: 10.1098/Rstb.1989.0059 |
0.6 |
|
| 1989 |
Sibanda BL, Blundell TL, Thornton JM. Conformation of beta-hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering. Journal of Molecular Biology. 206: 759-77. PMID 2500530 DOI: 10.1016/0022-2836(89)90583-4 |
0.405 |
|
| 1989 |
Greenfield C, Hiles I, Waterfield M, Federwisch M, Wollmer A, Blundell T, McDonald N. Epidermal growth factor binding induces a conformational change in the external domain of its receptor. The Embo Journal. 8: 4115-4123. DOI: 10.1002/J.1460-2075.1989.Tb08596.X |
0.544 |
|
| 1989 |
Sali A, Veerapandian B, Cooper J, Foundling S, Hoover D, Blundell T. High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme. The Embo Journal. 8: 2179-2188. DOI: 10.1002/J.1460-2075.1989.Tb08340.X |
0.45 |
|
| 1988 |
Blundell T, Carney D, Gardner S, Hayes F, Howlin B, Hubbard T, Overington J, Singh DA, Sibanda BL, Sutcliffe M. 18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design. European Journal of Biochemistry / Febs. 172: 513-20. PMID 3280310 DOI: 10.1111/J.1432-1033.1988.Tb13917.X |
0.667 |
|
| 1988 |
Thornton JM, Singh J, Campbell S, Blundell TL. Protein-protein recognition via side-chain interactions. Biochemical Society Transactions. 16: 927-30. PMID 3224756 DOI: 10.1042/Bst0160927 |
0.448 |
|
| 1988 |
Baudys̆ M, Foundling S, Pavlík M, Blundell T, Kostka V. Protein chemical characterization of Mucor pusillus aspartic proteinase. Amino acid sequence homology with the other aspartic proteinases, disulfide bond arrangement and site of carbohydrate attachment. Febs Letters. 235: 271-274. PMID 3042459 DOI: 10.1016/0014-5793(88)81277-8 |
0.339 |
|
| 1988 |
Blundell T. Protein structure, folding and design 2 Febs Letters. 238: 216-217. DOI: 10.1016/0014-5793(88)80261-8 |
0.367 |
|
| 1987 |
Bajaj M, Waterfield MD, Schlessinger J, Taylor WR, Blundell T. On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 916: 220-226. PMID 3676333 DOI: 10.1016/0167-4838(87)90112-9 |
0.324 |
|
| 1987 |
Blundell TL, Sibanda BL, Sternberg MJ, Thornton JM. Knowledge-based prediction of protein structures and the design of novel molecules. Nature. 326: 347-52. PMID 3550471 DOI: 10.1038/326347A0 |
0.516 |
|
| 1987 |
Blundell T, Cooper J, Foundling S, Jones D, Atrash B, Szelke M. On the rational design of renin inhibitors: X-ray studies of aspartic proteinases complexed with transition-state analogues. Biochemistry. 26: 5585-5590. PMID 3314991 DOI: 10.1021/Bi00392A001 |
0.32 |
|
| 1987 |
Cooper J, Foundling S, Hemmings A, Blundell T, Jones DM, Hallett A, Szelke M. The structure of a synthetic pepsin inhibitor complexed with endothiapepsin Febs Journal. 169: 215-221. PMID 3119339 DOI: 10.1111/J.1432-1033.1987.Tb13600.X |
0.326 |
|
| 1985 |
Wistow G, Slingsby C, Blundell T, Driessen H, De Jong W, Bloemendal H. Eye-lens proteins: the three-dimensional structure of beta-crystallin predicted from monomeric gamma-crystallin. Febs Letters. 133: 9-16. PMID 6927387 DOI: 10.1016/0014-5793(81)80460-7 |
0.399 |
|
| 1985 |
Wistow G, Summers L, Blundell T. Myxococcus xanthus spore coat protein S may have a similar structure to vertebrate lens βγ-crystallins Nature. 315: 771-773. PMID 3925350 DOI: 10.1038/315771A0 |
0.38 |
|
| 1985 |
Blundell T, Sternberg MJ. Computer-aided design in protein engineering Trends in Biotechnology. 3: 228-235. DOI: 10.1016/0167-7799(85)90013-7 |
0.421 |
|
| 1984 |
Glover I, Haneef I, Pitts J, Wood S, Moss D, Tickle I, Blundell T. Conformational flexibility in a small globular hormone: x-ray analysis of avian pancreatic polypeptide at 0.98-A resolution. Biopolymers. 22: 293-304. PMID 6673760 DOI: 10.1002/Bip.360220138 |
0.31 |
|
| 1984 |
Blundell T, Barlow D, Borkakoti N, Thornton J. Solvent-induced distortions and the curvature of alpha-helices. Nature. 306: 281-3. PMID 6646210 DOI: 10.1038/306281A0 |
0.469 |
|
| 1984 |
Sibanda BL, Blundell T, Hobart PM, Fogliano M, Bindra JS, Dominy BW, Chirgwin JM. Computer graphics modelling of human renin. Specificity, catalytic activity and intron-exon junctions Febs Letters. 174: 102-111. PMID 6432579 DOI: 10.1016/0014-5793(84)81086-8 |
0.356 |
|
| 1984 |
Pearl LH, Tickle IJ, Honegger A, Taylor GL, Barlow DJ, Thornton JM, Haneef I, Taylor WR, Blundell TL, Busetta B. The applications of computer calligraphics in protein engineering and drug design Acta Crystallographica Section a Foundations of Crystallography. 40: C42-C42. DOI: 10.1107/S0108767384098512 |
0.421 |
|
| 1983 |
Wistow G, Turnell B, Summers L, Slingsby C, Moss D, Miller L, Lindley P, Blundell T. X-ray analysis of the eye lens protein gamma-II crystallin at 1.9 A resolution. Journal of Molecular Biology. 170: 175-202. PMID 6631960 DOI: 10.1016/S0022-2836(83)80232-0 |
0.346 |
|
| 1983 |
Blundell T, Sibanda BL, Pearl L. Three-dimensional structure, specificity and catalytic mechanism of renin. Nature. 304: 273-275. PMID 6346109 DOI: 10.1038/304273A0 |
0.349 |
|
| 1982 |
Bedarkar S, Blundell T, Gowan LK, McDonald JK, Schwabe C. On the three-dimensional structure of relaxin. Annals of the New York Academy of Sciences. 380: 22-33. PMID 7044234 DOI: 10.1111/J.1749-6632.1982.Tb18025.X |
0.309 |
|
| 1981 |
Blundell T, Lindley P, Miller L, Moss D, Slingsby C, Tickle I, Turnell B, Wistow G. The molecular structure and stability of the eye lens: X-ray analysis of γ -crystallin II Nature. 289: 771-777. PMID 7464942 DOI: 10.1038/289771A0 |
0.362 |
|
| 1979 |
Blundell T. Conformation and molecular biology of polypeptide hormones II. Glucagon Trends in Biochemical Sciences. 4: 80-83. DOI: 10.1016/0968-0004(79)90187-7 |
0.304 |
|
| 1978 |
Tang J, James MN, Hsu IN, Jenkins JA, Blundell TL. Structural evidence for gene duplication in the evolution of the acid proteases. Nature. 271: 618-21. PMID 24179 DOI: 10.1038/271618A0 |
0.449 |
|
| 1977 |
Jenkins J, Tickle I, Sewell T, Ungaretti L, Wollmer A, Blundell T. X-ray analysis and circular dichroism of the acid protease from Endothia parasitica and chymosin Advances in Experimental Medicine and Biology. 95: 43-60. PMID 339693 DOI: 10.1007/978-1-4757-0719-9_4 |
0.335 |
|
| 1975 |
Sasaki K, Dockerill S, Adamiak DA, Tickle IJ, Blundell T. X-ray analysis of glucagon and its relationship to receptor binding Nature. 257: 751-757. PMID 171582 DOI: 10.1038/257751A0 |
0.326 |
|
| 1972 |
Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DC, Mercola DA. Three-dimensional atomic structure of insulin and its relationship to activity. Diabetes. 21: 492-505. PMID 5054329 DOI: 10.2337/Diab.21.2.S492 |
0.67 |
|
| 1972 |
Blundell TL, Cutfield JF, Dodson EJ, Dodson GG, Hodgkin DC, Mercola DA. The crystal structure of rhombohedral 2 zinc insulin. Cold Spring Harbor Symposia On Quantitative Biology. 36: 233-41. PMID 4508138 DOI: 10.1101/Sqb.1972.036.01.031 |
0.647 |
|
| 1972 |
Blundell T, Dodson G, Hodgkin D, Mercola D. Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by Advances in Protein Chemistry. 26. DOI: 10.1016/S0065-3233(08)60143-6 |
0.767 |
|
| 1971 |
Blundell TL, Cutfield JF, Dodson GG, Dodson E, Hodgkin DC, Mercola D. The structure and biology of insulin. The Biochemical Journal. 125: 50P-51P. PMID 5169433 DOI: 10.1042/Bj1250050P |
0.647 |
|
| 1971 |
Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DC, Mercola DA, Vijayan M. Atomic positions in rhombohedral 2-zinc insulin crystals. Nature. 231: 506-11. PMID 4932997 DOI: 10.1038/231506A0 |
0.63 |
|
| 1971 |
Blundell TL, Powell HM. Stereochemistry of cobalt complexes with heteronuclear metal-metal bonds: The crystal and molecular structure of tetracarbonyl(triphenylphosphineaurio) cobalt, and of tetracarbonyl{[bis-(o-dimethylarsinophenyl)methylarsine]argentio} cobalt Journal of the Chemical Society a: Inorganic, Physical, and Theoretical Chemistry. 1685-1690. DOI: 10.1039/J19710001685 |
0.624 |
|
| 1967 |
Blundell TL, Powell HM. The crystal and molecular structure of [Pd(TPAS)Cl]ClO3,C 6H6 [TPAS = o-phenylenebis-(o- dimethylarsinophenylmethylarsine)]: The stereochemistry of a pentaco-ordinate palladium complex ion Journal of the Chemical Society a: Inorganic, Physical, and Theoretical Chemistry. 1650-1657. DOI: 10.1039/J19670001650 |
0.618 |
|
| 1967 |
Blundell TL, Powell HM, Venanzi LM. A distorted trigonal bipyramidal co-ordination of cobalt in tris-(o-diphenylphosphinophenyl)phosphinochlorocobalt(II) tetraphenylborate Chemical Communications (London). 763-764. DOI: 10.1039/C19670000763 |
0.594 |
|
| 1967 |
Blundell TL, Powell HM. An unusual co-ordination of thallium in the crystal structure of dimethyl-1,10-phenanthrolinethallium perchlorate Chemical Communications (London). 54-55. DOI: 10.1039/C19670000054 |
0.646 |
|
| 1965 |
Kilbourn BT, Blundell TL, Powell HM. The molecular structures of bis-(o-dimethylarsinophenyl)methylarsinecopper- managanese pentacarbonyl, triphenylgermanium-manganese pentacarbonyl, and triphenylphosphinegold-cobalt tetracarbonyl Chemical Communications (London). 444-445. DOI: 10.1039/C19650000444 |
0.635 |
|
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