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Megan H. Powdrill, Ph.D. - Publications

Affiliations: 
2011 Department of Microbiology & Immunology McGill University, Montreal, QC, Canada 
Area:
Immunology, Virology Biology
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Shaw TA, Powdrill MH, Sherratt AR, Garland K, Li BJ, Beauchemin AM, Pezacki JP. Reactivity of -acyl hydrazone probes with the mammalian proteome. Rsc Medicinal Chemistry. 12: 797-803. PMID 34124678 DOI: 10.1039/d1md00027f  0.772
2020 Shaw T, Ablenas C, Desrochers GF, Powdrill M, Bilodeau DA, Vincent-Rocan JF, Niu M, Monette A, Mouland A, Beauchemin AM, Pezacki JP. A bifunctional nucleoside probe for the inhibition of the human immunodeficiency virus-type 1 reverse transcriptase. Bioconjugate Chemistry. PMID 32259429 DOI: 10.1021/Acs.Bioconjchem.0C00191  0.676
2019 Ablenas C, Gidi Y, Powdrill M, Ahmed N, Shaw T, Mesko M, Götte M, Cosa G, Pezacki JP. Hepatitis C virus helicase binding and activity monitored through site-specific labeling using an expanded genetic code. Acs Infectious Diseases. PMID 31640339 DOI: 10.1021/Acsinfecdis.9B00220  0.737
2019 Ahmed N, Foss DV, Powdrill MH, Pezacki JP. Site-Specific Cross-Linking of a p19 Viral Suppressor of RNA Silencing Protein and Its RNA Targets Using an Expanded Genetic Code. Biochemistry. PMID 31329415 DOI: 10.1021/Acs.Biochem.9B00428  0.611
2018 Shaw TA, Singaravelu R, Powdrill MH, Nhan J, Ahmed N, Özcelik D, Pezacki JP. MicroRNA-124 Regulates Fatty Acid and Triglyceride Homeostasis. Iscience. 10: 149-157. PMID 30528902 DOI: 10.1016/J.Isci.2018.11.028  0.567
2018 Singaravelu R, Quan C, Powdrill MH, Shaw TA, Srinivasan P, Lyn RK, Alonzi RC, Jones DM, Filip R, Russell RS, Pezacki JP. MicroRNA-7 mediates cross-talk between metabolic signaling pathways in the liver. Scientific Reports. 8: 361. PMID 29321595 DOI: 10.1038/S41598-017-18529-X  0.744
2018 Ablenas C, Powdrill M, Shaw T, Cosa G, Gotte M. A169 FLUORESCENT LABELING OF THE HCV HELICASE TO MONITOR NUCLEIC ACID UNWINDING BY FRET Journal of the Canadian Association of Gastroenterology. 1: 293-294. DOI: 10.1093/jcag/gwy008.170  0.753
2016 Strmiskova M, Desrochers GF, Shaw TA, Powdrill MH, Lafreniere MA, Pezacki JP. Chemical Methods for Probing Virus-Host Proteomic Interactions. Acs Infectious Diseases. 2: 773-786. PMID 27933785 DOI: 10.1021/Acsinfecdis.6B00084  0.712
2016 Lafreniere MA, Powdrill M, Singaravelu R, Pezacki JP. 6-hydroxydopamine inhibits the hepatitis C virus through alkylation of host and viral proteins and the induction of oxidative stress. Acs Infectious Diseases. PMID 27682680 DOI: 10.1021/Acsinfecdis.6B00098  0.765
2016 Powdrill MH, Desrochers GF, Singaravelu R, Pezacki JP. The role of microRNAs in metabolic interactions between viruses and their hosts. Current Opinion in Virology. 19: 71-76. PMID 27475325 DOI: 10.1016/J.Coviro.2016.07.005  0.766
2015 Danielson DC, Filip R, Powdrill MH, O'Hara S, Pezacki JP. Suppressing RNA silencing with small molecules and the viral suppressor of RNA silencing protein p19. Biochemical and Biophysical Research Communications. 463: 1135-40. PMID 26079891 DOI: 10.1016/J.Bbrc.2015.06.071  0.763
2014 Nasheri N, McKay CS, Fulton K, Twine S, Powdrill MH, Sherratt AR, Pezacki JP. Hydrophobic triaryl-substituted β-lactams as activity-based probes for profiling eukaryotic enzymes and host-pathogen interactions. Chembiochem : a European Journal of Chemical Biology. 15: 2195-200. PMID 25179744 DOI: 10.1002/Cbic.201402097  0.763
2014 Karam P, Powdrill MH, Liu HW, Vasquez C, Mah W, Bernatchez J, Götte M, Cosa G. Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNA. The Journal of Biological Chemistry. 289: 14399-411. PMID 24692556 DOI: 10.1074/Jbc.M113.529743  0.621
2014 Nasheri N, McKay CS, Fulton K, Twine S, Powdrill MH, Sherratt AR, Pezacki JP. Back Cover: Hydrophobic Triaryl-Substituted β-Lactams as Activity-Based Probes for Profiling Eukaryotic Enzymes and Host-Pathogen Interactions (ChemBioChem 15/2014) Chembiochem. 15: 2316-2316. DOI: 10.1002/Cbic.201490054  0.763
2011 Powdrill MH, Tchesnokov EP, Kozak RA, Russell RS, Martin R, Svarovskaia ES, Mo H, Kouyos RD, Götte M. Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance. Proceedings of the National Academy of Sciences of the United States of America. 108: 20509-13. PMID 22135458 DOI: 10.1073/Pnas.1105797108  0.573
2011 Berke JM, Vijgen L, Lachau-Durand S, Powdrill MH, Rawe S, Sjuvarsson E, Eriksson S, Götte M, Fransen E, Dehertogh P, Van den Eynde C, Leclercq L, Jonckers TH, Raboisson P, Nilsson M, et al. Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase. Antimicrobial Agents and Chemotherapy. 55: 3812-20. PMID 21576430 DOI: 10.1128/Aac.00214-11  0.304
2011 Karam P, Vasquez C, Mah W, Powdrill M, Aboukhalil R, Götte M, Cosa G. Single Molecule Studies Reveal Sliding Dynamics of Hcv NS5B in Complex with RNA Biophysical Journal. 100: 192a. DOI: 10.1016/J.Bpj.2010.12.1267  0.604
2010 Powdrill MH, Bernatchez JA, Götte M. Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B. Viruses. 2: 2169-95. PMID 21994615 DOI: 10.3390/V2102169  0.618
2010 Powdrill MH, Deval J, Narjes F, De Francesco R, Götte M. Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines. Antimicrobial Agents and Chemotherapy. 54: 977-83. PMID 20028820 DOI: 10.1128/Aac.01216-09  0.621
2010 Karam P, Vasquez C, Mah W, Powdrill M, Götte M, Cosa G. Single Molecule Studies on Hcv RNA Polymerase Activity Biophysical Journal. 98: 73a-74a. DOI: 10.1016/J.Bpj.2009.12.416  0.606
2010 Karam P, Vasquez C, Mah W, Powdrill M, Götte M, Cosa G. Mechanistic Studies at the Single Molecule Level Reveal the Dynamics of HCV Polymerase Protein in Complex with RNA Biophysical Journal. 98: 268a. DOI: 10.1016/J.Bpj.2009.12.1460  0.633
2007 Deval J, Powdrill MH, D'Abramo CM, Cellai L, Götte M. Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase. Antimicrobial Agents and Chemotherapy. 51: 2920-8. PMID 17502402 DOI: 10.1128/Aac.00186-07  0.601
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