| Year |
Citation |
Score |
| 2018 |
Wang X, Kastanenka KV, Arbel-Ornath M, Commins C, Kuzuya A, Lariviere AJ, Krafft GA, Hefti F, Jerecic J, Bacskai BJ. An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging. Scientific Reports. 8: 4634. PMID 29545579 DOI: 10.1038/S41598-018-22979-2 |
0.313 |
|
| 2004 |
Grimm J, Mueller A, Hefti F, Rosenthal A. Molecular basis for catecholaminergic neuron diversity. Proceedings of the National Academy of Sciences of the United States of America. 101: 13891-6. PMID 15353588 DOI: 10.1073/pnas.0405340101 |
0.423 |
|
| 2000 |
Harper SJ, Saporito MS, Hewson L, Young L, Smith D, Rigby M, Jackson P, Curtis N, Swain C, Hefti F, Vaught JL, Sirinathsinghji D. CEP-1347 increases ChAT activity in culture and promotes cholinergic neurone survival following fimbria-fornix lesion. Neuroreport. 11: 2271-6. PMID 10923684 DOI: 10.1097/00001756-200007140-00041 |
0.425 |
|
| 1999 |
Harper S, Bilsland J, Young L, Bristow L, Boyce S, Mason G, Rigby M, Hewson L, Smith D, O'Donnell R, O'Connor D, Hill RG, Evans D, Swain C, Williams B, ... Hefti F, et al. Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo. Neuroscience. 88: 257-67. PMID 10051205 DOI: 10.1016/S0306-4522(98)00221-8 |
0.322 |
|
| 1998 |
Venero JL, Hefti F. Regionally specific induction of BDNF and truncated trkB.T1 receptors in the hippocampal formation after intraseptal injection of kainic acid. Brain Research. 790: 270-7. PMID 9593933 DOI: 10.1016/S0006-8993(98)00071-7 |
0.346 |
|
| 1997 |
Hughes PE, Alexi T, Hefti F, Knusel B. Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun. Neuroscience. 78: 1037-49. PMID 9174072 DOI: 10.1016/S0306-4522(96)00623-9 |
0.333 |
|
| 1997 |
Knusel B, Gao H, Okazaki T, Yoshida T, Mori N, Hefti F, Kaplan DR. Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons. Neuroscience. 78: 851-62. PMID 9153663 DOI: 10.1016/S0306-4522(96)00616-1 |
0.421 |
|
| 1997 |
Alexi T, Venero JL, Hefti F. Protective effects of neurotrophin-4/5 and transforming growth factor-alpha on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acid. Neuroscience. 78: 73-86. PMID 9135090 DOI: 10.1016/S0306-4522(97)83046-1 |
0.439 |
|
| 1996 |
Beck KD, Irwin I, Valverde J, Brennan TJ, Langston JW, Hefti F. GDNF induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesis. Neuron. 16: 665-73. PMID 8785063 DOI: 10.1016/S0896-6273(00)80085-9 |
0.48 |
|
| 1996 |
Alexi T, Hefti F. Neurotrophin-4/5 selectively protects nigral calbindin-containing neurons in rats with medial forebrain bundle transections. Neuroscience. 72: 911-21. PMID 8735219 DOI: 10.1016/0306-4522(95)00607-9 |
0.471 |
|
| 1996 |
Qiao X, Hughes PE, Venero JL, Dugich-Djordjevic MM, Nichols NR, Hefti F, Knusel B. NT-4/5 protects against adrenalectomy-induced apoptosis of rat hippocampal granule cells. Neuroreport. 7: 682-6. PMID 8730856 DOI: 10.1097/00001756-199601310-00071 |
0.377 |
|
| 1996 |
Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, Hefti F. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and Cellular Neurosciences. 7: 222-38. PMID 8726105 DOI: 10.1006/Mcne.1996.0017 |
0.378 |
|
| 1996 |
Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, et al. Characterization of a multicomponent receptor for GDNF. Nature. 382: 80-3. PMID 8657309 DOI: 10.1038/382080A0 |
0.547 |
|
| 1996 |
Knusel B, Kaplan DR, Hefti F. Intraparenchymal NGF injections in adult and aged rats induce long-lasting Trk tyrosine phosphorylation. Experimental Neurology. 139: 121-30. PMID 8635559 DOI: 10.1006/exnr.1996.0087 |
0.386 |
|
| 1996 |
Venero JL, Hefti F, Knusel B. Trophic effect of exogenous nerve growth factor on rat striatal cholinergic neurons: comparison between intraparenchymal and intraventricular administration. Molecular Pharmacology. 49: 303-10. PMID 8632763 |
0.32 |
|
| 1996 |
Qiao X, Hefti F, Knusel B, Noebels JL. Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 640-8. PMID 8551348 DOI: 10.1523/Jneurosci.16-02-00640.1996 |
0.335 |
|
| 1995 |
Dugich-Djordjevic MM, Peterson C, Isono F, Ohsawa F, Widmer HR, Denton TL, Bennett GL, Hefti F. Immunohistochemical visualization of brain-derived neurotrophic factor in the rat brain. The European Journal of Neuroscience. 7: 1831-9. PMID 8528456 DOI: 10.1111/j.1460-9568.1995.tb00703.x |
0.367 |
|
| 1995 |
Beck KD, Valverde J, Alexi T, Poulsen K, Moffat B, Vandlen RA, Rosenthal A, Hefti F. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature. 373: 339-41. PMID 7830767 DOI: 10.1038/373339a0 |
0.465 |
|
| 1995 |
Venero JL, Hefti F, Beck KD. Retrograde transport of nerve growth factor from hippocampus and amygdala to trkA messenger RNA expressing neurons in paraventricular and reuniens nuclei of the thalamus. Neuroscience. 64: 855-60. PMID 7753386 DOI: 10.1016/0306-4522(94)00533-B |
0.378 |
|
| 1995 |
Winslow JW, Moran P, Valverde J, Shih A, Yuan JQ, Wong SC, Tsai SP, Goddard A, Henzel WJ, Hefti F. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron. 14: 973-81. PMID 7748564 DOI: 10.1016/0896-6273(95)90335-6 |
0.322 |
|
| 1995 |
Beck KD, Powell-Braxton L, Widmer HR, Valverde J, Hefti F. Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron. 14: 717-30. PMID 7718235 DOI: 10.1016/0896-6273(95)90216-3 |
0.357 |
|
| 1995 |
Dugich-Djordjevic MM, Ohsawa F, Okazaki T, Mori N, Day JR, Beck KD, Hefti F. Differential regulation of catalytic and non-catalytic trkB messenger RNAs in the rat hippocampus following seizures induced by systemic administration of kainate. Neuroscience. 66: 861-77. PMID 7651614 DOI: 10.1016/0306-4522(94)00631-E |
0.323 |
|
| 1995 |
Gao WQ, Dybdal N, Shinsky N, Murnane A, Schmelzer C, Siegel M, Keller G, Hefti F, Phillips HS, Winslow JW. Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy. Annals of Neurology. 38: 30-7. PMID 7611721 DOI: 10.1002/ana.410380108 |
0.334 |
|
| 1995 |
Beck KD, Hefti F. Induction of non-catalytic TrkB neurotrophin receptors during lesion-induced synaptic rearrangement in the adult rat hippocampus. Progress in Brain Research. 105: 197-210. PMID 7568878 DOI: 10.1016/S0079-6123(08)63296-3 |
0.397 |
|
| 1995 |
Treanor JJ, Schmelzer C, Knusel B, Winslow JW, Shelton DL, Hefti F, Nikolics K, Burton LE. Heterodimeric neurotrophins induce phosphorylation of Trk receptors and promote neuronal differentiation in PC12 cells. The Journal of Biological Chemistry. 270: 23104-10. PMID 7559453 DOI: 10.1074/jbc.270.39.23104 |
0.581 |
|
| 1994 |
Lapchak PA, Araujo DM, Hefti F. Effects of chronic nerve growth factor treatment on hippocampal [3H]cytisine/nicotinic binding sites and presynaptic nicotinic receptor function following fimbrial transections. Neuroscience. 60: 293-8. PMID 8072684 DOI: 10.1016/0306-4522(94)90243-7 |
0.419 |
|
| 1994 |
Venero JL, Knüsel B, Beck KD, Hefti F. Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration. Neuroscience. 59: 797-815. PMID 8058122 DOI: 10.1016/0306-4522(94)90285-2 |
0.413 |
|
| 1994 |
Venero JL, Beck KD, Hefti F. 6-Hydroxydopamine lesions reduce BDNF mRNA levels in adult rat brain substantia nigra. Neuroreport. 5: 429-32. PMID 8003668 DOI: 10.1097/00001756-199401120-00014 |
0.418 |
|
| 1994 |
Venero JL, Beck KD, Hefti F. Intrastriatal infusion of nerve growth factor after quinolinic acid prevents reduction of cellular expression of choline acetyltransferase messenger RNA and trkA messenger RNA, but not glutamate decarboxylase messenger RNA. Neuroscience. 61: 257-68. PMID 7969907 DOI: 10.1016/0306-4522(94)90229-1 |
0.399 |
|
| 1994 |
Widmer HR, Hefti F. Stimulation of GABAergic neuron differentiation by NT-4/5 in cultures of rat cerebral cortex. Brain Research. Developmental Brain Research. 80: 279-84. PMID 7955354 DOI: 10.1016/0165-3806(94)90114-7 |
0.424 |
|
| 1994 |
Widmer HR, Hefti F. Neurotrophin-4/5 promotes survival and differentiation of rat striatal neurons developing in culture. The European Journal of Neuroscience. 6: 1669-79. PMID 7874306 DOI: 10.1111/j.1460-9568.1994.tb00559.x |
0.441 |
|
| 1994 |
Beck KD, Hefti F, Widmer HR. Deafferentation removes calretinin immunopositive terminals, but does not induce degeneration of calbindin D-28k and parvalbumin expressing neurons in the hippocampus of adult rats. Journal of Neuroscience Research. 39: 298-304. PMID 7869422 DOI: 10.1002/jnr.490390307 |
0.381 |
|
| 1994 |
Hefti F. Neurotrophic factor therapy for nervous system degenerative diseases. Journal of Neurobiology. 25: 1418-35. PMID 7852995 DOI: 10.1002/neu.480251109 |
0.4 |
|
| 1994 |
Hefti F. Development of effective therapy for Alzheimer's disease based on neurotrophic factors. Neurobiology of Aging. 15: S193-4. PMID 7700452 DOI: 10.1016/0197-4580(94)90204-6 |
0.385 |
|
| 1993 |
Efange SM, Michelson RH, Knusel B, Hefti F, Boudreau RJ, Thomas JR, Tennison JR. Synthesis and biological evaluation of radioiodinated N-2-(4-piperidyl)ethyl benzamides. Nuclear Medicine and Biology. 20: 527-38. PMID 8504292 DOI: 10.1016/0969-8051(93)90083-7 |
0.309 |
|
| 1993 |
Hefti F, Lapchak PA. Pharmacology of nerve growth factor in the brain. Advances in Pharmacology (San Diego, Calif.). 24: 239-73. PMID 8504065 DOI: 10.1016/S1054-3589(08)60939-4 |
0.439 |
|
| 1993 |
Widmer HR, Alexi T, Valverde J, Knüsel B, Hefti F. TGF alpha stimulation of phosphatidylinositol hydrolysis in mesencephalic cultures requires neuron-glia interactions. Neuroreport. 4: 407-10. PMID 8499599 DOI: 10.1097/00001756-199304000-00017 |
0.37 |
|
| 1993 |
Widmer HR, Knüsel B, Hefti F. BDNF protection of basal forebrain cholinergic neurons after axotomy: complete protection of p75NGFR-positive cells. Neuroreport. 4: 363-6. PMID 8499589 DOI: 10.1097/00001756-199304000-00005 |
0.45 |
|
| 1993 |
Lapchak PA, Araujo DM, Hefti F. Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation. Neuroscience. 53: 297-301. PMID 8492907 DOI: 10.1016/0306-4522(93)90196-M |
0.427 |
|
| 1993 |
Widmer HR, Kaplan DR, Rabin SJ, Beck KD, Hefti F, Knüsel B. Rapid phosphorylation of phospholipase C gamma 1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat cortical neurons. Journal of Neurochemistry. 60: 2111-23. PMID 8492120 DOI: 10.1111/J.1471-4159.1993.Tb03496.X |
0.39 |
|
| 1993 |
Lapchak PA, Araujo DM, Beck KD, Finch CE, Johnson SA, Hefti F. BDNF and trkB mRNA expression in the hippocampal formation of aging rats. Neurobiology of Aging. 14: 121-6. PMID 8487914 DOI: 10.1016/0197-4580(93)90087-R |
0.311 |
|
| 1993 |
Lapchak PA, Araujo DM, Hefti F. BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions. Neuroreport. 4: 191-4. PMID 8453058 DOI: 10.1097/00001756-199302000-00019 |
0.358 |
|
| 1993 |
Lapchak PA, Araujo DM, Hefti F. Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: evidence from lesion and chronic cholinergic drug treatment studies. Neuroscience. 52: 575-85. PMID 8450959 DOI: 10.1016/0306-4522(93)90407-7 |
0.365 |
|
| 1993 |
Beck KD, Lamballe F, Klein R, Barbacid M, Schauwecker PE, McNeill TH, Finch CE, Hefti F, Day JR. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 4001-14. PMID 8396171 DOI: 10.1523/Jneurosci.13-09-04001.1993 |
0.393 |
|
| 1993 |
Lapchak PA, Araujo DM, Hefti F. Regulation of hippocampal muscarinic receptor function by chronic nerve growth factor treatment in adult rats with fimbrial transections. Neuroscience. 53: 379-94. PMID 8388084 DOI: 10.1016/0306-4522(93)90202-Q |
0.374 |
|
| 1993 |
Venero JL, Hefti F. TrkA NGF receptor expression by non-cholinergic thalamic neurons. Neuroreport. 4: 959-62. PMID 8369489 DOI: 10.1097/00001756-199307000-00031 |
0.37 |
|
| 1993 |
Araujo DM, Lapchak PA, Hefti F. Effects of chronic basic fibroblast growth factor administration to rats with partial fimbrial transections on presynaptic cholinergic parameters and muscarinic receptors in the hippocampus: comparison with nerve growth factor. Journal of Neurochemistry. 61: 899-910. PMID 8360689 DOI: 10.1111/J.1471-4159.1993.Tb03601.X |
0.406 |
|
| 1993 |
Widmer HR, Ohsawa F, Knüsel B, Hefti F. Down-regulation of phosphatidylinositol response to BDNF and NT-3 in cultures of cortical neurons. Brain Research. 614: 325-34. PMID 8348325 DOI: 10.1016/0006-8993(93)91051-S |
0.414 |
|
| 1993 |
Lapchak PA, Araujo DM, Carswell S, Hefti F. Distribution of [125I]nerve growth factor in the rat brain following a single intraventricular injection: correlation with the topographical distribution of trkA messenger RNA-expressing cells. Neuroscience. 54: 445-60. PMID 8336831 DOI: 10.1016/0306-4522(93)90265-H |
0.356 |
|
| 1993 |
Hefti F, Knusel B, Lapchak PA. Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections. Progress in Brain Research. 98: 257-63. PMID 8248515 DOI: 10.1016/S0079-6123(08)62407-3 |
0.443 |
|
| 1993 |
Lapchak PA, Araujo DM, Pasinetti G, Hefti F. Differential alterations of cortical cholinergic and neurotensin markers following ibotenic acid lesions of the nucleus basalis magnocellularis. Brain Research. 613: 239-46. PMID 8186970 DOI: 10.1016/0006-8993(93)90904-2 |
0.371 |
|
| 1993 |
Lapchak PA, Beck KD, Araujo DM, Irwin I, Langston JW, Hefti F. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience. 53: 639-50. PMID 8098137 DOI: 10.1016/0306-4522(93)90612-J |
0.46 |
|
| 1993 |
Beck KD, Knüsel B, Hefti F. The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth factor-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture. Neuroscience. 52: 855-66. PMID 8095710 DOI: 10.1016/0306-4522(93)90534-M |
0.393 |
|
| 1993 |
Ohsawa F, Widmer HR, Knusel B, Denton TL, Hefti F. Response of embryonic rat hippocampal neurons in culture to neurotrophin-3, brain-derived neurotrophic factor and basic fibroblast growth factor. Neuroscience. 57: 67-77. PMID 8074745 DOI: 10.1016/0306-4522(93)90112-S |
0.427 |
|
| 1993 |
Pallage V, Knusel B, Hefti F, Will B. Functional consequences of a single nerve growth factor administration following septal damage in rats. The European Journal of Neuroscience. 5: 669-79. PMID 7903189 DOI: 10.1111/J.1460-9568.1993.Tb00532.X |
0.397 |
|
| 1993 |
Alexi T, Hefti F. Trophic actions of transforming growth factor alpha on mesencephalic dopaminergic neurons developing in culture. Neuroscience. 55: 903-18. PMID 7901801 DOI: 10.1016/0306-4522(93)90307-2 |
0.354 |
|
| 1993 |
Knüsel B, Hefti F. Multiple and interactive responses of central neurons to neurotrophic factors Seminars in Neuroscience. 5: 259-267. DOI: 10.1016/S1044-5765(05)80031-4 |
0.406 |
|
| 1993 |
Araujo D, Lapchak P, Hefti F. Chronic NGF treatment alters hippocampal muscarinic receptor function in rats with fimbrial transections Life Sciences. 52: 588. DOI: 10.1016/0024-3205(93)90393-H |
0.331 |
|
| 1993 |
Lapchak P, Araujo D, Hefti F. Muscarinic receptor-mediated control of hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression Life Sciences. 52: 585. DOI: 10.1016/0024-3205(93)90387-I |
0.315 |
|
| 1992 |
Dugich-Djordjevic MM, Tocco G, Lapchak PA, Pasinetti GM, Najm I, Baudry M, Hefti F. Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid. Neuroscience. 47: 303-15. PMID 1641125 DOI: 10.1016/0306-4522(92)90246-X |
0.315 |
|
| 1992 |
Lapchak PA, Hefti F. BDNF and NGF treatment in lesioned rats: effects on cholinergic function and weight gain. Neuroreport. 3: 405-8. PMID 1633277 DOI: 10.1097/00001756-199205000-00007 |
0.439 |
|
| 1992 |
Knüsel B, Kaplan DR, Winslow JW, Rosenthal A, Burton LE, Beck KD, Rabin S, Nikolics K, Hefti F. K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3. Journal of Neurochemistry. 59: 715-22. PMID 1629741 DOI: 10.1111/j.1471-4159.1992.tb09427.x |
0.375 |
|
| 1992 |
Dugich-Djordjevic MM, Tocco G, Willoughby DA, Najm I, Pasinetti G, Thompson RF, Baudry M, Lapchak PA, Hefti F. BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity. Neuron. 8: 1127-38. PMID 1610567 DOI: 10.1016/0896-6273(92)90133-X |
0.318 |
|
| 1992 |
Lapchak PA, Jenden DJ, Hefti F. Pharmacological stimulation reveals recombinant human nerve growth factor-induced increases of in vivo hippocampal cholinergic function measured in rats with partial fimbrial transections. Neuroscience. 50: 847-56. PMID 1448201 DOI: 10.1016/0306-4522(92)90208-J |
0.407 |
|
| 1992 |
Knüsel B, Beck KD, Winslow JW, Rosenthal A, Burton LE, Widmer HR, Nikolics K, Hefti F. Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4391-402. PMID 1432101 DOI: 10.1523/Jneurosci.12-11-04391.1992 |
0.485 |
|
| 1992 |
Widmer HR, Knüsel B, Hefti F. Stimulation of phosphatidylinositol hydrolysis by brain-derived neurotrophic factor and neurotrophin-3 in rat cerebral cortical neurons developing in culture. Journal of Neurochemistry. 59: 2113-24. PMID 1431896 DOI: 10.1111/J.1471-4159.1992.Tb10102.X |
0.424 |
|
| 1992 |
Knüsel B, Hefti F. K-252 compounds: modulators of neurotrophin signal transduction. Journal of Neurochemistry. 59: 1987-96. PMID 1431889 DOI: 10.1111/J.1471-4159.1992.Tb10085.X |
0.309 |
|
| 1992 |
Knüsel B, Rabin S, Widmer HR, Hefti F, Kaplan DR. Neurotrophin-induced trk receptor phosphorylation and cholinergic neuron response in primary cultures of embryonic rat brain neurons. Neuroreport. 3: 885-8. PMID 1421094 DOI: 10.1097/00001756-199210000-00016 |
0.445 |
|
| 1992 |
Lorenzi MV, Knusel B, Hefti F, Strauss WL. Nerve growth factor regulation of choline acetyltransferase gene expression in rat embryo basal forebrain cultures. Neuroscience Letters. 140: 185-8. PMID 1380145 DOI: 10.1016/0304-3940(92)90098-R |
0.404 |
|
| 1991 |
Koliatsos VE, Applegate MD, Knüsel B, Junard EO, Burton LE, Mobley WC, Hefti FF, Price DL. Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat. Experimental Neurology. 112: 161-73. PMID 2037030 DOI: 10.1016/0014-4886(91)90066-L |
0.388 |
|
| 1991 |
Knüsel B, Winslow JW, Rosenthal A, Burton LE, Seid DP, Nikolics K, Hefti F. Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. Proceedings of the National Academy of Sciences of the United States of America. 88: 961-5. PMID 1992488 DOI: 10.1073/Pnas.88.3.961 |
0.485 |
|
| 1991 |
Lapchak PA, Hefti F. Effect of recombinant human nerve growth factor on presynaptic cholinergic function in rat hippocampal slices following partial septohippocampal lesions: measures of [3H]acetylcholine synthesis, [3H]acetylcholine release and choline acetyltransferase activity. Neuroscience. 42: 639-49. PMID 1956513 DOI: 10.1016/0306-4522(91)90033-K |
0.391 |
|
| 1991 |
Hefti F, Schneider LS. Nerve growth factor and Alzheimer's disease. Clinical Neuropharmacology. 14: S62-76. PMID 1913710 DOI: 10.1097/00002826-199114001-00008 |
0.409 |
|
| 1991 |
Lapchak PA, Jenden DJ, Hefti F. Compensatory elevation of acetylcholine synthesis in vivo by cholinergic neurons surviving partial lesions of the septohippocampal pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 2821-8. PMID 1880551 DOI: 10.1523/Jneurosci.11-09-02821.1991 |
0.403 |
|
| 1991 |
Knüsel B, Hefti F. K-252b is a selective and nontoxic inhibitor of nerve growth factor action on cultured brain neurons. Journal of Neurochemistry. 57: 955-62. PMID 1861160 DOI: 10.1111/J.1471-4159.1991.Tb08243.X |
0.366 |
|
| 1991 |
Koliatsos VE, Clatterbuck RE, Nauta HJ, Knüsel B, Burton LE, Hefti FF, Mobley WC, Price DL. Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. Annals of Neurology. 30: 831-40. PMID 1789695 DOI: 10.1002/Ana.410300613 |
0.378 |
|
| 1991 |
Knusel B, Hefti F. Trophic actions of IGF-I, IGF-II and insulin on cholinergic and dopaminergic brain neurons. Advances in Experimental Medicine and Biology. 293: 351-60. PMID 1767736 DOI: 10.1007/978-1-4684-5949-4_31 |
0.304 |
|
| 1991 |
Lapchak PA, Hefti F. Emerging pharmacology of nerve growth factor. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 15: 851-60. PMID 1763196 DOI: 10.1016/0278-5846(91)90013-Q |
0.372 |
|
| 1991 |
Hefti F, Junard EO, Knüsel B, Strauss WL, Strang PF, Przybylski A, Vaughan G, Fox SW. Promotion of neuronal survival in vitro by thermal proteins and poly(dicarboxylic)amino acids. Brain Research. 541: 273-83. PMID 1711399 DOI: 10.1016/0006-8993(91)91028-Y |
0.361 |
|
| 1991 |
Beck KD, Knusel B, Pasinetti G, Michel PP, Zawadzka H, Goldstein M, Hefti F. Tyrosine hydroxylase mRNA expression by dopaminergic neurons in culture: effect of 1-methyl-4-phenylpyridinium treatment. Journal of Neurochemistry. 57: 527-32. PMID 1677030 DOI: 10.1111/J.1471-4159.1991.Tb03782.X |
0.433 |
|
| 1991 |
Schwaber JS, Due BR, Rogers WT, Junard EO, Sharma A, Hefti F. Use of a digital brain atlas to compare the distribution of NGF- and bFGF-protected cholinergic neurons. The Journal of Comparative Neurology. 309: 27-39. PMID 1654343 DOI: 10.1002/cne.903090104 |
0.446 |
|
| 1990 |
Knusel B, Michel PP, Schwaber JS, Hefti F. Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 558-70. PMID 2406380 DOI: 10.1523/Jneurosci.10-02-00558.1990 |
0.373 |
|
| 1990 |
Michel PP, Dandapani BK, Efange SM, Hefti F. Potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium: selective toxicity of 1-methyl-4-(4'-acetamidophenyl)-pyridinium and 1-methyl-4-cyclohexylpyridinium for dopaminergic neurons in culture. Experimental Neurology. 108: 141-50. PMID 2335192 DOI: 10.1016/0014-4886(90)90021-J |
0.37 |
|
| 1990 |
Knüsel B, Burton LE, Longo FM, Mobley WC, Koliatsos VE, Price DL, Hefti F. Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells. Experimental Neurology. 110: 274-83. PMID 2249737 DOI: 10.1016/0014-4886(90)90039-U |
0.448 |
|
| 1990 |
Junard EO, Montero CN, Hefti F. Long-term administration of mouse nerve growth factor to adult rats with partial lesions of the cholinergic septohippocampal pathway. Experimental Neurology. 110: 25-38. PMID 2170164 DOI: 10.1016/0014-4886(90)90048-W |
0.439 |
|
| 1990 |
Hefti F, Knusel B, Michel PP. Selective and non-selective trophic actions on central cholinergic and dopaminergic neurons in vitro. Progress in Brain Research. 86: 145-55. PMID 2087555 DOI: 10.1016/S0079-6123(08)63173-8 |
0.448 |
|
| 1990 |
Michel PP, Hefti F. Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture. Journal of Neuroscience Research. 26: 428-35. PMID 1977925 DOI: 10.1002/jnr.490260405 |
0.445 |
|
| 1990 |
Michel PP, Dandapani BK, Knusel B, Sanchez-Ramos J, Hefti F. Toxicity of 1-methyl-4-phenylpyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility. Journal of Neurochemistry. 54: 1102-9. PMID 1968953 DOI: 10.1111/J.1471-4159.1990.Tb01935.X |
0.416 |
|
| 1989 |
Efange SM, Mash D, Hefti F, Kung HF, Billings J. Selective visualization of rodent locus ceruleus by a radiolabeled N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analog. Journal of Neurochemistry. 53: 459-64. PMID 2787390 DOI: 10.1111/J.1471-4159.1989.Tb07356.X |
0.366 |
|
| 1989 |
Hefti F, Hartikka J, Knusel B. Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases. Neurobiology of Aging. 10: 515-33. PMID 2682327 DOI: 10.1016/0197-4580(89)90118-8 |
0.321 |
|
| 1989 |
Phelps CH, Gage FH, Growdon JH, Hefti F, Harbaugh R, Johnston MV, Khachaturian ZS, Mobley WC, Price DL, Raskind M. Potential use of nerve growth factor to treat Alzheimer's disease. Neurobiology of Aging. 10: 205-7. PMID 2657468 DOI: 10.1016/0197-4580(89)90032-8 |
0.501 |
|
| 1989 |
Montero CN, Hefti F. Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats. Neurobiology of Aging. 10: 739-43. PMID 2628784 DOI: 10.1016/0197-4580(89)90011-0 |
0.448 |
|
| 1989 |
Hefti F, Mash DC. Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease. Neurobiology of Aging. 10: 75-87. PMID 2547172 DOI: 10.1016/S0197-4580(89)80014-4 |
0.423 |
|
| 1988 |
Knusel B, Hefti F. Development of cholinergic pedunculopontine neurons in vitro: comparison with cholinergic septal cells and response to nerve growth factor, ciliary neuronotrophic factor, and retinoic acid. Journal of Neuroscience Research. 21: 365-75. PMID 3216429 DOI: 10.1002/jnr.490210228 |
0.465 |
|
| 1988 |
Hartikka J, Hefti F. Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro. Journal of Neuroscience Research. 21: 352-64. PMID 3216428 DOI: 10.1002/jnr.490210227 |
0.458 |
|
| 1988 |
Hefti F, Knusel B. Chronic administration of nerve growth factor and other neurotrophic factors to the brain. Neurobiology of Aging. 9: 689-90. PMID 3211267 DOI: 10.1016/S0197-4580(88)80133-7 |
0.379 |
|
| 1988 |
Sanchez-Ramos JR, Michel P, Weiner WJ, Hefti F. Selective destruction of cultured dopaminergic neurons from fetal rat mesencephalon by 1-methyl-4-phenylpyridinium: cytochemical and morphological evidence. Journal of Neurochemistry. 50: 1934-44. PMID 2897430 DOI: 10.1111/J.1471-4159.1988.Tb02500.X |
0.415 |
|
| 1988 |
Montero CN, Hefti F. Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2986-99. PMID 2842469 DOI: 10.1523/Jneurosci.08-08-02986.1988 |
0.457 |
|
| 1988 |
Hartikka J, Hefti F. Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2967-85. PMID 2842468 DOI: 10.1523/Jneurosci.08-08-02967.1988 |
0.417 |
|
| 1987 |
Fox SW, Hefti F, Hartikka J, Junard E, Przybylski AT, Vaughan G. Pharmacological activities in thermal proteins: relationships in molecular evolution. International Journal of Quantum Chemistry. Quantum Biology Symposium : Proceedings of the International Symposium On Quantum Biology and Quantum Pharmacology. International Symposium On Quantum Biology and Quantum Pharmacology. 14: 347-9. PMID 11542106 DOI: 10.1002/Qua.560320832 |
0.35 |
|
| 1987 |
Vibulsreth S, Hefti F, Ginsberg MD, Dietrich WD, Busto R. Astrocytes protect cultured neurons from degeneration induced by anoxia. Brain Research. 422: 303-11. PMID 3676791 DOI: 10.1016/0006-8993(87)90937-1 |
0.382 |
|
| 1987 |
Gähwiler BH, Enz A, Hefti F. Nerve growth factor promotes development of the rat septo-hippocampal cholinergic projection in vitro. Neuroscience Letters. 75: 6-10. PMID 3574769 DOI: 10.1016/0304-3940(87)90066-8 |
0.367 |
|
| 1987 |
Hefti F. (1S,2R)-5-methoxy-1-methyl-2-(n-propylamino)tetralin ([+]-AJ-76) elevates transmitter synthesis in dopaminergic neurons surviving a partial nigrostriatal lesion. Neuropharmacology. 26: 1239-41. PMID 2889167 DOI: 10.1016/0028-3908(87)90276-0 |
0.459 |
|
| 1987 |
Hefti F, Will B. Nerve growth factor is a neurotrophic factor for forebrain cholinergic neurons; implications for Alzheimer's disease. Journal of Neural Transmission. Supplementum. 24: 309-15. PMID 2824691 |
0.384 |
|
| 1986 |
Pallage V, Toniolo G, Will B, Hefti F. Long-term effects of nerve growth factor and neural transplants on behavior of rats with medial septal lesions. Brain Research. 386: 197-208. PMID 3779409 DOI: 10.1016/0006-8993(86)90156-3 |
0.376 |
|
| 1986 |
Hefti F, Hartikka J, Bolger MB. Effect of thyroid hormone analogs on the activity of choline acetyltransferase in cultures of dissociated septal cells. Brain Research. 375: 413-6. PMID 3730832 DOI: 10.1016/0006-8993(86)90769-9 |
0.41 |
|
| 1986 |
Korsching S, Heumann R, Thoenen H, Hefti F. Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content. Neuroscience Letters. 66: 175-80. PMID 3725184 DOI: 10.1016/0304-3940(86)90186-2 |
0.412 |
|
| 1986 |
Hefti F, Weiner WJ. Nerve growth factor and Alzheimer's disease. Annals of Neurology. 20: 275-81. PMID 3532929 DOI: 10.1002/Ana.410200302 |
0.444 |
|
| 1986 |
Hefti F, Hartikka J, Salvatierra A, Weiner WJ, Mash DC. Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain. Neuroscience Letters. 69: 37-41. PMID 3018635 DOI: 10.1016/0304-3940(86)90410-6 |
0.442 |
|
| 1986 |
Sanchez-Ramos J, Barrett JN, Goldstein M, Weiner WJ, Hefti F. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in cultures of dissociated rat mesencephalic neurons. Neuroscience Letters. 72: 215-20. PMID 2880321 DOI: 10.1016/0304-3940(86)90083-2 |
0.45 |
|
| 1986 |
Toniolo G, Dunnett S, Hefti F, Will B. Influence of endogenous and exogenous growth factors on choline-acetyltransferase (ChAT) activity in rats with fimbria-fornix lesions and acetylcholine-rich transplants in the hippocampus Behavioural Brain Research. 20: 152. DOI: 10.1016/0166-4328(86)90217-2 |
0.374 |
|
| 1985 |
Hefti F, Hartikka J, Schlumpf M. Implantation of PC12 cells into the corpus striatum of rats with lesions of the dopaminergic nigrostriatal neurons. Brain Research. 348: 283-8. PMID 4075086 DOI: 10.1016/0006-8993(85)90446-9 |
0.45 |
|
| 1985 |
Toniolo G, Dunnett SB, Hefti F, Will B. Acetylcholine-rich transplants in the hippocampus: influence of intrinsic growth factors and application of nerve growth factor on choline acetyltransferase activity. Brain Research. 345: 141-6. PMID 4063798 DOI: 10.1016/0006-8993(85)90844-3 |
0.393 |
|
| 1985 |
Melamed E, Hefti F. Altered pharmacokinetics of L-dopa metabolism. Neurology. 35: 939-41. PMID 4000502 DOI: 10.1212/Wnl.35.6.939-A |
0.465 |
|
| 1985 |
Hefti F, Hartikka J, Eckenstein F, Gnahn H, Heumann R, Schwab M. Nerve growth factor increases choline acetyltransferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons. Neuroscience. 14: 55-68. PMID 3974885 DOI: 10.1016/0306-4522(85)90163-0 |
0.418 |
|
| 1985 |
Hefti F, Enz A, Melamed E. Partial lesions of the nigrostriatal pathway in the rat. Acceleration of transmitter synthesis and release of surviving dopaminergic neurones by drugs. Neuropharmacology. 24: 19-23. PMID 2858830 DOI: 10.1016/0028-3908(85)90090-5 |
0.597 |
|
| 1984 |
Hefti F, Dravid A, Hartikka J. Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions. Brain Research. 293: 305-11. PMID 6697222 |
0.312 |
|
| 1984 |
Melamed E, Hefti F, Bitton V, Globus M. Suppression of L-dopa-induced circling in rats with nigral lesions by blockade of central dopa-decarboxylase: implications for mechanism of action of L-dopa in parkinsonism. Neurology. 34: 1566-70. PMID 6504328 DOI: 10.1212/WNL.34.12.1566 |
0.595 |
|
| 1984 |
Enz A, Hefti F, Frick W. Acute administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces dopamine and serotonin but accelerates norepinephrine metabolism in the rat brain. Effect of chronic pretreatment with MPTP. European Journal of Pharmacology. 101: 37-44. PMID 6086364 |
0.347 |
|
| 1983 |
Gnahn H, Hefti F, Heumann R, Schwab ME, Thoenen H. NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain? Brain Research. 285: 45-52. PMID 6136314 DOI: 10.1016/0165-3806(83)90107-4 |
0.431 |
|
| 1983 |
Harper GP, Barde YA, Edgar D, Ganten D, Hefti F, Heumann R, Naujoks KW, Rohrer H, Turner JE, Thoenen H. Biological and immunological properties of the nerve growth factor from bovine seminal plasma: comparison with the properties of mouse nerve growth factor. Neuroscience. 8: 375-87. PMID 6133237 DOI: 10.1016/0306-4522(83)90073-8 |
0.376 |
|
| 1982 |
Lichtensteiger W, Hefti F, Felix D, Huwyler T, Melamed E, Schlumpf M. Stimulation of nigrostriatal dopamine neurones by nicotine. Neuropharmacology. 21: 963-8. PMID 7145035 DOI: 10.1016/0028-3908(82)90107-1 |
0.57 |
|
| 1982 |
Melamed E, Hefti F, Bird ED. Huntington chorea is not associated with hyperactivity of nigrostriatal dopaminergic neurons: studies in postmortem tissues and in rats with kainic acid lesions. Neurology. 32: 640-4. PMID 6211637 DOI: 10.1212/WNL.32.6.640 |
0.592 |
|
| 1982 |
Growdon JH, Melamed E, Logue M, Hefti F, Wurtman RJ. Effects of oral L-tyrosine administration on CSF tyrosine and homovanillic acid levels in patients with Parkinson's disease. Life Sciences. 30: 827-32. PMID 6175872 DOI: 10.1016/0024-3205(82)90596-3 |
0.686 |
|
| 1982 |
Hefti F, Gnahn H, Schwab ME, Thoenen H. Induction of tyrosine hydroxylase by nerve growth factor and by elevated K+ concentrations in cultures of dissociated sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 2: 1554-66. PMID 6128379 DOI: 10.1523/Jneurosci.02-11-01554.1982 |
0.377 |
|
| 1982 |
Melamed E, Hefti F, Wurtman RJ. Compensatory mechanisms in the nigrostriatal dopaminergic system in Parkinson's disease: studies in an animal model. Israel Journal of Medical Sciences. 18: 159-63. PMID 6121770 |
0.589 |
|
| 1982 |
Hefti F, Melamed E. Chronic dopa feeding of mice Neurology. 32: 685-685. DOI: 10.1212/WNL.32.6.685 |
0.433 |
|
| 1981 |
Hefti F, Melamed E. Dopamine release in rat striatum after administration of L-dope as studied with in vivo electrochemistry. Brain Research. 225: 333-46. PMID 7306794 DOI: 10.1016/0006-8993(81)90840-4 |
0.569 |
|
| 1981 |
Hefti F, Melamed E, Wurtman RJ. The site of dopamine formation in rat striatum after L-dopa administration. The Journal of Pharmacology and Experimental Therapeutics. 217: 189-97. PMID 7205652 |
0.58 |
|
| 1981 |
Melamed E, Hefti F, Pettibone DJ, Liebman J, Wurtman RJ. Aromatic L-amino acid decarboxylase in rat corpus striatum: implications for action of L-dopa in parkinsonism. Neurology. 31: 651-5. PMID 7195482 DOI: 10.1212/WNL.31.6.651 |
0.759 |
|
| 1981 |
Hefti F, Melamed E, Bhawan J, Wurtman RJ. Long-term administration of L-DOPA does not damage dopaminergic neurons in the mouse Neurology. 31: 1194-1194. DOI: 10.1212/WNL.31.9.1194 |
0.657 |
|
| 1981 |
Hefti F, Melamed E. Reply from Hefti and Melamed Trends in Neurosciences. 4: 150. DOI: 10.1016/0166-2236(81)90050-3 |
0.404 |
|
| 1980 |
Morre MC, Hefti F, Wurtman RJ. Regional tyrosine levels in rat brain after tyrosine administration. Journal of Neural Transmission. 49: 45-50. PMID 7441238 DOI: 10.1007/BF01249188 |
0.495 |
|
| 1980 |
Melamed E, Hefti F, Wurtman RJ. Decarboxylation of exogenous L-DOPA in rat striatum after lesions of the dopaminergic nigrostriatal neurons: the role of striatal capillaries. Brain Research. 198: 244-8. PMID 7407592 DOI: 10.1016/0006-8993(80)90363-7 |
0.68 |
|
| 1980 |
Melamed E, Hefti F, Wurtman RJ. Diminished decarboxylation of L-DOPA in rat striatum after intrastriatal injections of kainic acid. Neuropharmacology. 19: 409-11. PMID 7383284 DOI: 10.1016/0028-3908(80)90194-X |
0.682 |
|
| 1980 |
Melamed E, Hefti F, Wurtman RJ. L-3,4-Dihydroxyphenylalanine and L-5-hydroxytryptophan decarboxylase activities in rat striatum: effect of selective destruction of dopaminergic or serotoninergic input. Journal of Neurochemistry. 34: 1753-6. PMID 7381499 DOI: 10.1111/j.1471-4159.1980.tb11270.x |
0.615 |
|
| 1980 |
Hefti F, Melamed E, Sahakian BJ, Wurtman RJ. Circling behavior in rats with partial, unilateral nigro-striatal lesions: effect of amphetamine, apomorphine, and DOPA. Pharmacology, Biochemistry, and Behavior. 12: 185-8. PMID 7189592 DOI: 10.1016/0091-3057(80)90353-6 |
0.703 |
|
| 1980 |
Hefti F, Melamed E, Wurtman RJ. The decarboxylation of DOPA in the parkinsonian brain: in vivo studies on an animal model. Journal of Neural Transmission. Supplementum. 95-101. PMID 6776238 DOI: 10.1007/978-3-7091-8582-7_10 |
0.661 |
|
| 1980 |
Melamed E, Hefti F, Wurtman RJ. Nonaminergic striatal neurons convert exogenous L-dopa to dopamine in parkinsonism. Annals of Neurology. 8: 558-63. PMID 6260009 DOI: 10.1002/ana.410080603 |
0.683 |
|
| 1980 |
Melamed E, Hefti F, Wurtman RJ. Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions. Proceedings of the National Academy of Sciences of the United States of America. 77: 4305-9. PMID 6254020 DOI: 10.1073/PNAS.77.7.4305 |
0.678 |
|
| 1980 |
Wurtman RJ, Hefti F, Melamed E. Precursor control of neurotransmitter synthesis. Pharmacological Reviews. 32: 315-35. PMID 6115400 |
0.506 |
|
| 1980 |
Hefti F, Melamed E, Wurtman RJ. Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization. Brain Research. 195: 123-37. PMID 6105003 DOI: 10.1016/0006-8993(80)90871-9 |
0.703 |
|
| 1980 |
Melamed E, Hefti F, Liebman J, Schlosberg AJ, Wurtman RJ. Serotonergic neurones are not involved in action of L-dopa in Parkinson's disease. Nature. 283: 772-4. PMID 6101905 DOI: 10.1038/283772A0 |
0.688 |
|
| 1980 |
Hefti F, Melamed E. l-DOPA's mechanism of action in Parkinson's disease Trends in Neurosciences. 3: 229-231. DOI: 10.1016/S0166-2236(80)80070-1 |
0.502 |
|
| 1977 |
Lichtensteiger W, Felix D, Lienhart R, Hefti F. A quantitative correlation between single unit activity and fluorescence intensity of dopamine neurones in zona compacta of substantia nigra, as demonstrated under the influence of nicotine and physostigmine. Brain Research. 117: 85-103. PMID 990937 DOI: 10.1016/0006-8993(76)90558-8 |
0.303 |
|
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