| Year |
Citation |
Score |
| 2023 |
Jbara A, Lin KT, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL, Yaron TM, Ovadia O, Jang GH, Danan-Gotthold M, Cantley LC, ... ... Krainer AR, et al. RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Nature. PMID 36949200 DOI: 10.1038/s41586-023-05820-3 |
0.327 |
|
| 2023 |
Hastings ML, Krainer AR. RNA therapeutics. Rna (New York, N.Y.). 29: 393-395. PMID 36928165 DOI: 10.1261/rna.079626.123 |
0.65 |
|
| 2022 |
Kim YJ, Nomakuchi T, Papaleonidopoulou F, Yang L, Zhang Q, Krainer AR. Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy. Nature Communications. 13: 2978. PMID 35624092 DOI: 10.1038/s41467-022-30668-y |
0.323 |
|
| 2022 |
Gao Y, Lin KT, Jiang T, Yang Y, Rahman MA, Gong S, Bai J, Wang L, Sun J, Sheng L, Krainer AR, Hua Y. Systematic characterization of short intronic splicing-regulatory elements in SMN2 pre-mRNA. Nucleic Acids Research. PMID 35018432 DOI: 10.1093/nar/gkab1280 |
0.438 |
|
| 2022 |
Kim YJ, Sivetz N, Layne J, Voss DM, Yang L, Zhang Q, Krainer AR. Exon-skipping antisense oligonucleotides for cystic fibrosis therapy. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35017301 DOI: 10.1073/pnas.2114858118 |
0.344 |
|
| 2021 |
Ajiro M, Awaya T, Kim YJ, Iida K, Denawa M, Tanaka N, Kurosawa R, Matsushima S, Shibata S, Sakamoto T, Studer R, Krainer AR, Hagiwara M. Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. Nature Communications. 12: 4507. PMID 34301951 DOI: 10.1038/s41467-021-24705-5 |
0.328 |
|
| 2020 |
Frederiksen SB, Holm LL, Larsen MR, Doktor TK, Andersen HS, Hastings ML, Hua Y, Krainer AR, Andresen BS. Identification of SRSF10 as a regulator of SMN2 ISS-N1. Human Mutation. PMID 33300159 DOI: 10.1002/humu.24149 |
0.703 |
|
| 2020 |
Sheng L, Rigo F, Bennett CF, Krainer AR, Hua Y. Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model. Nucleic Acids Research. PMID 32103257 DOI: 10.1093/Nar/Gkaa126 |
0.314 |
|
| 2020 |
Rahman MA, Lin KT, Bradley RK, Abdel-Wahab O, Krainer AR. Recurrent SRSF2 mutations in MDS affect both splicing and NMD. Genes & Development. PMID 32001512 DOI: 10.1101/Gad.332270.119 |
0.519 |
|
| 2020 |
Rahman MA, Krainer AR, Abdel-Wahab O. SnapShot: Splicing Alterations in Cancer. Cell. 180: 208-208.e1. PMID 31951519 DOI: 10.1016/J.Cell.2019.12.011 |
0.49 |
|
| 2019 |
Scharner J, Ma WK, Zhang Q, Lin KT, Rigo F, Bennett CF, Krainer AR. Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides. Nucleic Acids Research. PMID 31802121 DOI: 10.1093/Nar/Gkz1132 |
0.418 |
|
| 2019 |
Park S, Brugiolo M, Akerman M, Das S, Urbanski L, Geier A, Kesarwani AK, Fan M, Leclair N, Lin KT, Hu L, Hua I, George J, Muthuswamy SK, Krainer AR, et al. Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis. Cell Reports. 29: 2672-2688.e7. PMID 31775037 DOI: 10.1016/J.Celrep.2019.10.110 |
0.352 |
|
| 2019 |
Yoshimi A, Lin KT, Wiseman DH, Rahman MA, Pastore A, Wang B, Lee SC, Micol JB, Zhang XJ, de Botton S, Penard-Lacronique V, Stein EM, Cho H, Miles RE, Inoue D, ... ... Krainer AR, et al. Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis. Nature. PMID 31578525 DOI: 10.1038/S41586-019-1618-0 |
0.466 |
|
| 2019 |
Feng H, Bao S, Rahman MA, Weyn-Vanhentenryck SM, Khan A, Wong J, Shah A, Flynn ED, Krainer AR, Zhang C. Modeling RNA-Binding Protein Specificity In Vivo by Precisely Registering Protein-RNA Crosslink Sites. Molecular Cell. 74: 1189-1204.e6. PMID 31226278 DOI: 10.1016/J.Molcel.2019.02.002 |
0.505 |
|
| 2019 |
Lin KT, Krainer AR. PSI-Sigma: a comprehensive splicing-detection method for short-read and long-read RNA-seq analysis. Bioinformatics (Oxford, England). PMID 31135034 DOI: 10.1093/Bioinformatics/Btz438 |
0.421 |
|
| 2019 |
Wang E, Lu SX, Pastore A, Chen X, Imig J, Chun-Wei Lee S, Hockemeyer K, Ghebrechristos YE, Yoshimi A, Inoue D, Ki M, Cho H, Bitner L, Kloetgen A, Lin KT, ... ... Krainer AR, et al. Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia. Cancer Cell. PMID 30799057 DOI: 10.1016/J.Ccell.2019.01.010 |
0.48 |
|
| 2019 |
Lin K, Krainer AR. PSI-Sigma: a comprehensive splicing-detection method for short-read and long-read RNA-seq analysis F1000research. 8. DOI: 10.7490/F1000Research.1117603.1 |
0.368 |
|
| 2019 |
Li J, Lin X, Tang C, Lu Y, Hu X, Zuo E, Li H, Ying W, Sun Y, Lai L, Chen H, Guo X, Zhang Q, Wu S, Zhou C, ... ... Krainer AR, et al. Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice National Science Review. 7: 92-101. DOI: 10.1093/Nsr/Nwz131 |
0.379 |
|
| 2018 |
Wong MS, Kinney JB, Krainer AR. Quantitative Activity Profile and Context Dependence of All Human 5' Splice Sites. Molecular Cell. PMID 30174293 DOI: 10.1016/J.Molcel.2018.07.033 |
0.465 |
|
| 2018 |
Aznarez I, Nomakuchi TT, Tetenbaum-Novatt J, Rahman MA, Fregoso O, Rees H, Krainer AR. Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1. Cell Reports. 23: 2186-2198. PMID 29768215 DOI: 10.1016/J.Celrep.2018.04.039 |
0.8 |
|
| 2018 |
Sinha R, Kim YJ, Nomakuchi T, Sahashi K, Hua Y, Rigo F, Bennett CF, Krainer AR. Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice. Nucleic Acids Research. PMID 29672717 DOI: 10.1093/nar/gky249 |
0.378 |
|
| 2018 |
Lin KT, Ma WK, Scharner J, Liu YR, Krainer AR. A human-specific switch of alternatively splicedisoforms contributes tomutations and tumor recurrence in hepatocellular carcinoma. Genome Research. PMID 29449409 DOI: 10.1101/Gr.227181.117 |
0.331 |
|
| 2018 |
Lu SX, Wang E, Pastore A, Xufeng C, Imig J, Lee SC, Ghebrechristos Y, Yoshimi A, Bitner LE, Ki M, Kloetgen A, Lin K, Tibes R, Krainer AR, Uehara T, et al. Therapeutic Targeting of an RNA Splicing Factor Network for the Treatment of Myeloid Neoplasms Blood. 132: 427-427. DOI: 10.1182/Blood-2018-99-111430 |
0.489 |
|
| 2017 |
Sivaramakrishnan M, McCarthy KD, Campagne S, Huber S, Meier S, Augustin A, Heckel T, Meistermann H, Hug MN, Birrer P, Moursy A, Khawaja S, Schmucki R, Berntenis N, Giroud N, ... ... Krainer AR, et al. Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers. Nature Communications. 8: 1476. PMID 29133793 DOI: 10.1038/S41467-017-01559-4 |
0.443 |
|
| 2017 |
Wu X, Wang SH, Sun J, Krainer AR, Hua Y, Prior TW. A-44G transition in SMN2 intron 6 protects patients with spinal muscular atrophy. Human Molecular Genetics. PMID 28460014 DOI: 10.1093/Hmg/Ddx166 |
0.404 |
|
| 2017 |
Jangi M, Fleet C, Cullen P, Gupta SV, Mekhoubad S, Chiao E, Allaire N, Bennett CF, Rigo F, Krainer AR, Hurt JA, Carulli JP, Staropoli JF. SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage. Proceedings of the National Academy of Sciences of the United States of America. PMID 28270613 DOI: 10.1073/Pnas.1613181114 |
0.322 |
|
| 2017 |
Sivaramakrishnan M, McCarthy KD, Huber S, Campagne S, Meier S, Augustin A, Heckel T, Meistermann H, Hug M, Birrer P, Moursy A, Khawaja S, Schmucki R, Berntenis N, Giroud N, ... ... Krainer AR, et al. Binding to a novel RNA-protein complex creates specificity for small molecule splicing modifiers to treat SMA Neuromuscular Disorders. 27. DOI: 10.1016/S0960-8966(17)30315-2 |
0.433 |
|
| 2016 |
Allemand E, Myers MP, Garcia-Bernardo J, Harel-Bellan A, Krainer AR, Muchardt C. A Broad Set of Chromatin Factors Influences Splicing. Plos Genetics. 12: e1006318. PMID 27662573 DOI: 10.1371/Journal.Pgen.1006318 |
0.434 |
|
| 2016 |
Doktor TK, Hua Y, Andersen HS, Brøner S, Liu YH, Wieckowska A, Dembic M, Bruun GH, Krainer AR, Andresen BS. RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns. Nucleic Acids Research. PMID 27557711 DOI: 10.1093/Nar/Gkw731 |
0.436 |
|
| 2016 |
Anczuków O, Krainer AR. Splicing-factor alterations in cancers. Rna (New York, N.Y.). 22: 1285-301. PMID 27530828 DOI: 10.1261/Rna.057919.116 |
0.437 |
|
| 2016 |
Bruun GH, Doktor TK, Borch-Jensen J, Masuda A, Krainer AR, Ohno K, Andresen BS. Global identification of hnRNP A1 binding sites for SSO-based splicing modulation. Bmc Biology. 14: 54. PMID 27380775 DOI: 10.1186/S12915-016-0279-9 |
0.48 |
|
| 2016 |
Krainer A. Spliceosome: Physiology and Disease Pathogenesis Blood. 128: SCI-17-SCI-17. DOI: 10.1182/Blood.V128.22.Sci-17.Sci-17 |
0.522 |
|
| 2016 |
Anczuków O, Das S, Lin K, Wu J, Akerman M, Muthuswamy SK, Krainer AR. Abstract A50: Nonredundant functions of splicing factors in breast-cancer initiation and metastasis Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-A50 |
0.393 |
|
| 2016 |
Arun G, Diermeier S, Akerman M, Chang K, Wilkinson JE, Hearn S, Kim Y, MacLeod AR, Krainer AR, Norton L, Brogi E, Egeblad M, Spector DL. Abstract PR11: Differentiation of mammary tumors and reduction in metastasis upon Malat1 LncRNA loss Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-Pr11 |
0.338 |
|
| 2015 |
Arun G, Diermeier S, Akerman M, Chang KC, Wilkinson JE, Hearn S, Kim Y, MacLeod AR, Krainer AR, Norton L, Brogi E, Egeblad M, Spector DL. Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes & Development. PMID 26701265 DOI: 10.1101/Gad.270959.115 |
0.34 |
|
| 2015 |
Nomakuchi TT, Rigo F, Aznarez I, Krainer AR. Antisense oligonucleotide-directed inhibition of nonsense-mediated mRNA decay. Nature Biotechnology. PMID 26655495 DOI: 10.1038/Nbt.3427 |
0.44 |
|
| 2015 |
Anczuków O, Krainer AR. The spliceosome, a potential Achilles heel of MYC-driven tumors. Genome Medicine. 7: 107. PMID 26490253 DOI: 10.1186/S13073-015-0234-3 |
0.407 |
|
| 2015 |
Anczuków O, Akerman M, Cléry A, Wu J, Shen C, Shirole NH, Raimer A, Sun S, Jensen MA, Hua Y, Allain FH, Krainer AR. SRSF1-Regulated Alternative Splicing in Breast Cancer. Molecular Cell. 60: 105-17. PMID 26431027 DOI: 10.1016/J.Molcel.2015.09.005 |
0.45 |
|
| 2015 |
Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y, Lu Y, Wu Y, Jia Z, Li W, Zhang MQ, ... ... Krainer AR, et al. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell. 162: 900-10. PMID 26276636 DOI: 10.1016/J.Cell.2015.07.038 |
0.726 |
|
| 2015 |
Akerman M, Fregoso OI, Das S, Ruse C, Jensen MA, Pappin DJ, Zhang MQ, Krainer AR. Differential connectivity of splicing activators and repressors to the human spliceosome. Genome Biology. 16: 119. PMID 26047612 DOI: 10.1186/S13059-015-0682-5 |
0.789 |
|
| 2015 |
Krainer AR. Splicing: still so much to learn. Rna (New York, N.Y.). 21: 500-1. PMID 25780112 DOI: 10.1261/Rna.050641.115 |
0.534 |
|
| 2015 |
Staropoli JF, Li H, Chun SJ, Allaire N, Cullen P, Thai A, Fleet CM, Hua Y, Bennett CF, Krainer AR, Kerr D, McCampbell A, Rigo F, Carulli JP. Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7. Genomics. 105: 220-8. PMID 25645699 DOI: 10.1016/J.Ygeno.2015.01.007 |
0.372 |
|
| 2015 |
Xiong HY, Alipanahi B, Lee LJ, Bretschneider H, Merico D, Yuen RK, Hua Y, Gueroussov S, Najafabadi HS, Hughes TR, Morris Q, Barash Y, Krainer AR, Jojic N, Scherer SW, et al. RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease. Science (New York, N.Y.). 347: 1254806. PMID 25525159 DOI: 10.1126/Science.1254806 |
0.422 |
|
| 2014 |
Chen HH, Welling M, Bloch DB, Muñoz J, Mientjes E, Chen X, Tramp C, Wu J, Yabuuchi A, Chou YF, Buecker C, Krainer A, Willemsen R, Heck AJ, Geijsen N. DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells. Stem Cell Reports. 3: 892-904. PMID 25418731 DOI: 10.1016/J.Stemcr.2014.09.003 |
0.42 |
|
| 2014 |
Paz S, Krainer AR, Caputi M. HIV-1 transcription is regulated by splicing factor SRSF1. Nucleic Acids Research. 42: 13812-23. PMID 25416801 DOI: 10.1093/Nar/Gku1170 |
0.456 |
|
| 2014 |
Senturk S, Yao Z, Camiolo M, Stiles B, Rathod T, Walsh AM, Nemajerova A, Lazzara MJ, Altorki NK, Krainer A, Moll UM, Lowe SW, Cartegni L, Sordella R. p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proceedings of the National Academy of Sciences of the United States of America. 111: E3287-96. PMID 25074920 DOI: 10.1073/Pnas.1321640111 |
0.379 |
|
| 2014 |
Das S, Krainer AR. Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer. Molecular Cancer Research : McR. 12: 1195-204. PMID 24807918 DOI: 10.1158/1541-7786.Mcr-14-0131 |
0.481 |
|
| 2014 |
Rigo F, Chun SJ, Norris DA, Hung G, Lee S, Matson J, Fey RA, Gaus H, Hua Y, Grundy JS, Krainer AR, Henry SP, Bennett CF. Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates. The Journal of Pharmacology and Experimental Therapeutics. 350: 46-55. PMID 24784568 DOI: 10.1124/Jpet.113.212407 |
0.322 |
|
| 2014 |
Weyn-Vanhentenryck SM, Mele A, Yan Q, Sun S, Farny N, Zhang Z, Xue C, Herre M, Silver PA, Zhang MQ, Krainer AR, Darnell RB, Zhang C. HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Reports. 6: 1139-52. PMID 24613350 DOI: 10.1016/J.Celrep.2014.02.005 |
0.435 |
|
| 2014 |
Jensen MA, Wilkinson JE, Krainer AR. Splicing factor SRSF6 promotes hyperplasia of sensitized skin. Nature Structural & Molecular Biology. 21: 189-97. PMID 24440982 DOI: 10.1038/Nsmb.2756 |
0.378 |
|
| 2013 |
Cléry A, Sinha R, Anczuków O, Corrionero A, Moursy A, Daubner GM, Valcárcel J, Krainer AR, Allain FH. Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition. Proceedings of the National Academy of Sciences of the United States of America. 110: E2802-11. PMID 23836656 DOI: 10.1073/Pnas.1303445110 |
0.476 |
|
| 2013 |
Das S, Fregoso OI, Krainer AR. A new path to oncogene-induced senescence: at the crossroads of splicing and translation. Cell Cycle (Georgetown, Tex.). 12: 1477-9. PMID 23624837 DOI: 10.4161/Cc.24749 |
0.779 |
|
| 2013 |
Wu J, Anczuków O, Krainer AR, Zhang MQ, Zhang C. OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds. Nucleic Acids Research. 41: 5149-63. PMID 23571760 DOI: 10.1093/Nar/Gkt216 |
0.336 |
|
| 2013 |
Fregoso OI, Das S, Akerman M, Krainer AR. Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence. Molecular Cell. 50: 56-66. PMID 23478443 DOI: 10.1016/J.Molcel.2013.02.001 |
0.782 |
|
| 2013 |
Roca X, Krainer AR, Eperon IC. Pick one, but be quick: 5' splice sites and the problems of too many choices. Genes & Development. 27: 129-44. PMID 23348838 DOI: 10.1101/Gad.209759.112 |
0.472 |
|
| 2013 |
Ben-Hur V, Denichenko P, Siegfried Z, Maimon A, Krainer A, Davidson B, Karni R. S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1 Cell Reports. 3: 103-115. PMID 23273915 DOI: 10.1016/J.Celrep.2012.11.020 |
0.363 |
|
| 2013 |
Clery A, Sinha R, Anczukow O, Corrionero A, Moursy A, Daubner G, Valcarcel J, Krainer A, Allain F. Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3' Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2M8D/Pdb |
0.349 |
|
| 2013 |
Anczukow O, Lin K, Das S, Wu J, Akerman M, Muthuswamy SK, Krainer AR. Abstract A078: Differential functions of splicing factors in breast cancer initiation and metastasis Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A078 |
0.401 |
|
| 2013 |
Anczukow O, Lin K, Akerman M, Das S, Muthuswamy SK, Krainer A. Abstract B53: Differential functions of splicing factors in breast-cancer initiation and metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-B53 |
0.399 |
|
| 2012 |
Wang Z, Jeon HY, Rigo F, Bennett CF, Krainer AR. Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides. Open Biology. 2: 120133. PMID 23155487 DOI: 10.1098/Rsob.120133 |
0.342 |
|
| 2012 |
Sahashi K, Hua Y, Ling KK, Hung G, Rigo F, Horev G, Katsuno M, Sobue G, Ko CP, Bennett CF, Krainer AR. TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals. Genes & Development. 26: 1874-84. PMID 22895255 DOI: 10.1101/Gad.197418.112 |
0.371 |
|
| 2012 |
Roca X, Akerman M, Gaus H, Berdeja A, Bennett CF, Krainer AR. Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides. Genes & Development. 26: 1098-109. PMID 22588721 DOI: 10.1101/Gad.190173.112 |
0.47 |
|
| 2012 |
Das S, Anczuków O, Akerman M, Krainer AR. Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC. Cell Reports. 1: 110-7. PMID 22545246 DOI: 10.1016/J.Celrep.2011.12.001 |
0.458 |
|
| 2012 |
Rigo F, Hua Y, Chun SJ, Prakash TP, Krainer AR, Bennett CF. Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing. Nature Chemical Biology. 8: 555-61. PMID 22504300 DOI: 10.1038/Nchembio.939 |
0.504 |
|
| 2012 |
Hua Y, Krainer AR. Antisense-mediated exon inclusion. Methods in Molecular Biology (Clifton, N.J.). 867: 307-23. PMID 22454070 DOI: 10.1007/978-1-61779-767-5_20 |
0.456 |
|
| 2012 |
Kole R, Krainer AR, Altman S. RNA therapeutics: beyond RNA interference and antisense oligonucleotides. Nature Reviews. Drug Discovery. 11: 125-40. PMID 22262036 DOI: 10.1038/Nrd3625 |
0.46 |
|
| 2012 |
Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nature Structural & Molecular Biology. 19: 220-8. PMID 22245967 DOI: 10.1038/Nsmb.2207 |
0.367 |
|
| 2012 |
Sun S, Zhang Z, Fregoso O, Krainer AR. Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2. Rna (New York, N.Y.). 18: 274-83. PMID 22184459 DOI: 10.1261/Rna.030486.111 |
0.804 |
|
| 2012 |
Wang Z, Chatterjee D, Jeon HY, Akerman M, Vander Heiden MG, Cantley LC, Krainer AR. Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. Journal of Molecular Cell Biology. 4: 79-87. PMID 22044881 DOI: 10.1093/Jmcb/Mjr030 |
0.415 |
|
| 2012 |
Krainer A. Pre-mRNA Splicing Mechanisms, Misregulation in Disease, and Therapeutic Strategies Blood. 120: SCI-13-SCI-13. DOI: 10.1182/Blood.V120.21.Sci-13.Sci-13 |
0.516 |
|
| 2011 |
Hua Y, Sahashi K, Rigo F, Hung G, Horev G, Bennett CF, Krainer AR. Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model. Nature. 478: 123-6. PMID 21979052 DOI: 10.1038/Nature10485 |
0.323 |
|
| 2011 |
Wu J, Akerman M, Sun S, McCombie WR, Krainer AR, Zhang MQ. SpliceTrap: a method to quantify alternative splicing under single cellular conditions. Bioinformatics (Oxford, England). 27: 3010-6. PMID 21896509 DOI: 10.1093/Bioinformatics/Btr508 |
0.48 |
|
| 2011 |
Cho S, Hoang A, Sinha R, Zhong XY, Fu XD, Krainer AR, Ghosh G. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proceedings of the National Academy of Sciences of the United States of America. 108: 8233-8. PMID 21536904 DOI: 10.1073/Pnas.1017700108 |
0.618 |
|
| 2011 |
Kubota T, Roca X, Kimura T, Kokunai Y, Nishino I, Sakoda S, Krainer AR, Takahashi MP. A mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia. Human Mutation. 32: 773-82. PMID 21412952 DOI: 10.1002/Humu.21501 |
0.386 |
|
| 2011 |
Passini MA, Bu J, Richards AM, Kinnecom C, Sardi SP, Stanek LM, Hua Y, Rigo F, Matson J, Hung G, Kaye EM, Shihabuddin LS, Krainer AR, Bennett CF, Cheng SH. Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy. Science Translational Medicine. 3: 72ra18. PMID 21368223 DOI: 10.1126/Scitranslmed.3001777 |
0.304 |
|
| 2011 |
Thorsen K, Mansilla F, Schepeler T, Øster B, Rasmussen MH, Dyrskjøt L, Karni R, Akerman M, Krainer AR, Laurberg S, Andersen CL, Ørntoft TF. Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway. Molecular & Cellular Proteomics : McP. 10: M110.002998. PMID 20938052 DOI: 10.1074/Mcp.M110.002998 |
0.389 |
|
| 2010 |
Hua Y, Sahashi K, Hung G, Rigo F, Passini MA, Bennett CF, Krainer AR. Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model. Genes & Development. 24: 1634-44. PMID 20624852 DOI: 10.1101/Gad.1941310 |
0.343 |
|
| 2010 |
Manley JL, Krainer AR. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes & Development. 24: 1073-4. PMID 20516191 DOI: 10.1101/Gad.1934910 |
0.492 |
|
| 2010 |
Sinha R, Allemand E, Zhang Z, Karni R, Myers MP, Krainer AR. Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF. Molecular and Cellular Biology. 30: 2762-74. PMID 20308322 DOI: 10.1128/Mcb.01270-09 |
0.414 |
|
| 2010 |
Sun S, Zhang Z, Sinha R, Karni R, Krainer AR. SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control. Nature Structural & Molecular Biology. 17: 306-12. PMID 20139984 DOI: 10.1038/Nsmb.1750 |
0.528 |
|
| 2010 |
Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 1894-9. PMID 20133837 DOI: 10.1073/Pnas.0914845107 |
0.371 |
|
| 2010 |
Anczukow O, Rosenberg A, Muthuswamy SK, Krainer AR. Abstract 1: Role of the splicing factor SF2/ASF in mammary epithelial cell transformation Cancer Research. 70: 1-1. DOI: 10.1158/1538-7445.Am10-1 |
0.415 |
|
| 2009 |
Hastings ML, Berniac J, Liu YH, Abato P, Jodelka FM, Barthel L, Kumar S, Dudley C, Nelson M, Larson K, Edmonds J, Bowser T, Draper M, Higgins P, Krainer AR. Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Science Translational Medicine. 1: 5ra12. PMID 20161659 DOI: 10.1126/Scitranslmed.3000208 |
0.679 |
|
| 2009 |
Prior TW, Krainer AR, Hua Y, Swoboda KJ, Snyder PC, Bridgeman SJ, Burghes AH, Kissel JT. A positive modifier of spinal muscular atrophy in the SMN2 gene. American Journal of Human Genetics. 85: 408-13. PMID 19716110 DOI: 10.1016/J.Ajhg.2009.08.002 |
0.328 |
|
| 2009 |
Okunola HL, Krainer AR. Cooperative-binding and splicing-repressive properties of hnRNP A1. Molecular and Cellular Biology. 29: 5620-31. PMID 19667073 DOI: 10.1128/Mcb.01678-08 |
0.443 |
|
| 2009 |
Khoo B, Krainer AR. Splicing therapeutics in SMN2 and APOB. Current Opinion in Molecular Therapeutics. 11: 108-15. PMID 19330716 |
0.36 |
|
| 2009 |
Roca X, Krainer AR. A splicing component adapted to gene silencing. Nature Biotechnology. 27: 250-1. PMID 19270672 DOI: 10.1038/Nbt0309-250 |
0.368 |
|
| 2009 |
Martins de Araújo M, Bonnal S, Hastings ML, Krainer AR, Valcárcel J. Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP. Rna (New York, N.Y.). 15: 515-23. PMID 19244360 DOI: 10.1261/rna.1273209 |
0.745 |
|
| 2009 |
Roca X, Krainer AR. Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA. Nature Structural & Molecular Biology. 16: 176-82. PMID 19169258 DOI: 10.1038/Nsmb.1546 |
0.452 |
|
| 2008 |
Karni R, Hippo Y, Lowe SW, Krainer AR. The splicing-factor oncoprotein SF2/ASF activates mTORC1. Proceedings of the National Academy of Sciences of the United States of America. 105: 15323-7. PMID 18832178 DOI: 10.1073/Pnas.0801376105 |
0.314 |
|
| 2008 |
Zhang C, Zhang Z, Castle J, Sun S, Johnson J, Krainer AR, Zhang MQ. Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes & Development. 22: 2550-63. PMID 18794351 DOI: 10.1101/Gad.1703108 |
0.452 |
|
| 2008 |
Steitz JA, Dreyfuss G, Krainer AR, Lamond AI, Matera AG, Padgett RA. Where in the cell is the minor spliceosome? Proceedings of the National Academy of Sciences of the United States of America. 105: 8485-6. PMID 18562285 DOI: 10.1073/Pnas.0804024105 |
0.416 |
|
| 2008 |
Chen G, Li W, Zhang QS, Regulski M, Sinha N, Barditch J, Tully T, Krainer AR, Zhang MQ, Dubnau J. Identification of synaptic targets of Drosophila pumilio. Plos Computational Biology. 4: e1000026. PMID 18463699 DOI: 10.1371/Journal.Pcbi.1000026 |
0.412 |
|
| 2008 |
Zhang C, Li WH, Krainer AR, Zhang MQ. RNA landscape of evolution for optimal exon and intron discrimination. Proceedings of the National Academy of Sciences of the United States of America. 105: 5797-802. PMID 18391195 DOI: 10.1073/Pnas.0801692105 |
0.513 |
|
| 2008 |
Hua Y, Vickers TA, Okunola HL, Bennett CF, Krainer AR. Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice. American Journal of Human Genetics. 82: 834-48. PMID 18371932 DOI: 10.1016/J.Ajhg.2008.01.014 |
0.43 |
|
| 2008 |
Thorsen K, Sørensen KD, Brems-Eskildsen AS, Modin C, Gaustadnes M, Hein AM, Kruhøffer M, Laurberg S, Borre M, Wang K, Brunak S, Krainer AR, Tørring N, Dyrskjøt L, Andersen CL, et al. Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. Molecular & Cellular Proteomics : McP. 7: 1214-24. PMID 18353764 DOI: 10.1074/Mcp.M700590-Mcp200 |
0.328 |
|
| 2008 |
Majerciak V, Yamanegi K, Allemand E, Kruhlak M, Krainer AR, Zheng ZM. Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing. Journal of Virology. 82: 2792-801. PMID 18184716 DOI: 10.1128/Jvi.01856-07 |
0.472 |
|
| 2008 |
Roca X, Olson AJ, Rao AR, Enerly E, Kristensen VN, Børresen-Dale AL, Andresen BS, Krainer AR, Sachidanandam R. Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics. Genome Research. 18: 77-87. PMID 18032726 DOI: 10.1101/Gr.6859308 |
0.365 |
|
| 2007 |
Zhang C, Hastings ML, Krainer AR, Zhang MQ. Dual-specificity splice sites function alternatively as 5' and 3' splice sites. Proceedings of the National Academy of Sciences of the United States of America. 104: 15028-33. PMID 17848517 DOI: 10.1073/Pnas.0703773104 |
0.722 |
|
| 2007 |
Shaw SD, Chakrabarti S, Ghosh G, Krainer AR. Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. Plos One. 2: e854. PMID 17786225 DOI: 10.1371/Journal.Pone.0000854 |
0.436 |
|
| 2007 |
Zhang C, Krainer AR, Zhang MQ. Evolutionary impact of limited splicing fidelity in mammalian genes. Trends in Genetics : Tig. 23: 484-8. PMID 17719121 DOI: 10.1016/J.Tig.2007.08.001 |
0.332 |
|
| 2007 |
Caceres JF, Krainer AR, Kornblihtt AR. The pathology of pre-mRNA splicing: a meeting in the Italian Alps. Workshop on pre-mRNA processing and disease. Embo Reports. 8: 730-4. PMID 17668002 DOI: 10.1038/Sj.Embor.7401032 |
0.674 |
|
| 2007 |
Zhang Z, Krainer AR. Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components. Proceedings of the National Academy of Sciences of the United States of America. 104: 11574-9. PMID 17606899 DOI: 10.1073/Pnas.0704946104 |
0.487 |
|
| 2007 |
Das R, Yu J, Zhang Z, Gygi MP, Krainer AR, Gygi SP, Reed R. SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. Molecular Cell. 26: 867-81. PMID 17588520 DOI: 10.1016/J.Molcel.2007.05.036 |
0.612 |
|
| 2007 |
Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR. Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65). Plos One. 2: e538. PMID 17579712 DOI: 10.1371/Journal.Pone.0000538 |
0.76 |
|
| 2007 |
Allemand E, Hastings ML, Murray MV, Myers MP, Krainer AR. Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1. Nature Structural & Molecular Biology. 14: 630-8. PMID 17572683 DOI: 10.1038/Nsmb1257 |
0.733 |
|
| 2007 |
Hua Y, Vickers TA, Baker BF, Bennett CF, Krainer AR. Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon. Plos Biology. 5: e73. PMID 17355180 DOI: 10.1371/Journal.Pbio.0050073 |
0.491 |
|
| 2007 |
Wimmer K, Roca X, Beiglböck H, Callens T, Etzler J, Rao AR, Krainer AR, Fonatsch C, Messiaen L. Extensive in silico analysis of NF1 splicing defects uncovers determinants for splicing outcome upon 5' splice-site disruption. Human Mutation. 28: 599-612. PMID 17311297 DOI: 10.1002/Humu.20493 |
0.439 |
|
| 2007 |
Karni R, de Stanchina E, Lowe SW, Sinha R, Mu D, Krainer AR. The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nature Structural & Molecular Biology. 14: 185-93. PMID 17310252 DOI: 10.1038/Nsmb1209 |
0.376 |
|
| 2007 |
Nielsen KB, Sørensen S, Cartegni L, Corydon TJ, Doktor TK, Schroeder LD, Reinert LS, Elpeleg O, Krainer AR, Gregersen N, Kjems J, Andresen BS. Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer. American Journal of Human Genetics. 80: 416-32. PMID 17273963 DOI: 10.1086/511992 |
0.413 |
|
| 2007 |
Khoo B, Roca X, Chew SL, Krainer AR. Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB. Bmc Molecular Biology. 8: 3. PMID 17233885 DOI: 10.1186/1471-2199-8-3 |
0.483 |
|
| 2006 |
Sheth N, Roca X, Hastings ML, Roeder T, Krainer AR, Sachidanandam R. Comprehensive splice-site analysis using comparative genomics. Nucleic Acids Research. 34: 3955-67. PMID 16914448 DOI: 10.1093/Nar/Gkl556 |
0.698 |
|
| 2006 |
Smith PJ, Zhang C, Wang J, Chew SL, Zhang MQ, Krainer AR. An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers. Human Molecular Genetics. 15: 2490-508. PMID 16825284 DOI: 10.1093/Hmg/Ddl171 |
0.403 |
|
| 2006 |
Zhang QS, Manche L, Xu RM, Krainer AR. hnRNP A1 associates with telomere ends and stimulates telomerase activity. Rna (New York, N.Y.). 12: 1116-28. PMID 16603717 DOI: 10.1261/Rna.58806 |
0.356 |
|
| 2006 |
Cartegni L, Hastings ML, Calarco JA, de Stanchina E, Krainer AR. Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2. American Journal of Human Genetics. 78: 63-77. PMID 16385450 DOI: 10.1086/498853 |
0.736 |
|
| 2006 |
Madsen PP, Kibaek M, Roca X, Sachidanandam R, Krainer AR, Christensen E, Steiner RD, Gibson KM, Corydon TJ, Knudsen I, Wanders RJ, Ruiter JP, Gregersen N, Andresen BS. Short/branched-chain acyl-CoA dehydrogenase deficiency due to an IVS3+3A>G mutation that causes exon skipping. Human Genetics. 118: 680-90. PMID 16317551 DOI: 10.1007/S00439-005-0070-4 |
0.356 |
|
| 2005 |
Wang J, Smith PJ, Krainer AR, Zhang MQ. Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes. Nucleic Acids Research. 33: 5053-62. PMID 16147989 DOI: 10.1093/Nar/Gki810 |
0.485 |
|
| 2005 |
Tyson-Capper AJ, Bailey J, Krainer AR, Robson SC, Europe-Finner GN. The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40. The Journal of Biological Chemistry. 280: 34521-9. PMID 16103121 DOI: 10.1074/Jbc.M505344200 |
0.447 |
|
| 2005 |
Roca X, Sachidanandam R, Krainer AR. Determinants of the inherent strength of human 5' splice sites. Rna (New York, N.Y.). 11: 683-98. PMID 15840817 DOI: 10.1261/Rna.2040605 |
0.385 |
|
| 2005 |
Allemand E, Guil S, Myers M, Moscat J, Cáceres JF, Krainer AR. Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. Proceedings of the National Academy of Sciences of the United States of America. 102: 3605-10. PMID 15738418 DOI: 10.1073/Pnas.0409889102 |
0.612 |
|
| 2005 |
Coutinho G, Xie J, Du L, Brusco A, Krainer AR, Gatti RA. Functional significance of a deep intronic mutation in the ATM gene and evidence for an alternative exon 28a. Human Mutation. 25: 118-24. PMID 15643608 DOI: 10.1002/Humu.20170 |
0.372 |
|
| 2005 |
Hastings ML, Resta N, Traum D, Stella A, Guanti G, Krainer AR. An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites. Nature Structural & Molecular Biology. 12: 54-9. PMID 15608654 DOI: 10.1038/Nsmb873 |
0.723 |
|
| 2004 |
Zhang Z, Krainer AR. Involvement of SR proteins in mRNA surveillance. Molecular Cell. 16: 597-607. PMID 15546619 DOI: 10.1016/J.Molcel.2004.10.031 |
0.527 |
|
| 2004 |
Zatkova A, Messiaen L, Vandenbroucke I, Wieser R, Fonatsch C, Krainer AR, Wimmer K. Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1. Human Mutation. 24: 491-501. PMID 15523642 DOI: 10.1002/Humu.20103 |
0.387 |
|
| 2004 |
Muraki M, Ohkawara B, Hosoya T, Onogi H, Koizumi J, Koizumi T, Sumi K, Yomoda J, Murray MV, Kimura H, Furuichi K, Shibuya H, Krainer AR, Suzuki M, Hagiwara M. Manipulation of alternative splicing by a newly developed inhibitor of Clks. The Journal of Biological Chemistry. 279: 24246-54. PMID 15010457 DOI: 10.1074/Jbc.M314298200 |
0.476 |
|
| 2003 |
Domsic JK, Wang Y, Mayeda A, Krainer AR, Stoltzfus CM. Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts. Molecular and Cellular Biology. 23: 8762-72. PMID 14612416 DOI: 10.1128/Mcb.23.23.8762-8772.2003 |
0.45 |
|
| 2003 |
Roca X, Sachidanandam R, Krainer AR. Intrinsic differences between authentic and cryptic 5' splice sites. Nucleic Acids Research. 31: 6321-33. PMID 14576320 DOI: 10.1093/Nar/Gkg830 |
0.403 |
|
| 2003 |
Cartegni L, Wang J, Zhu Z, Zhang MQ, Krainer AR. ESEfinder: A web resource to identify exonic splicing enhancers. Nucleic Acids Research. 31: 3568-71. PMID 12824367 DOI: 10.1093/Nar/Gkg616 |
0.423 |
|
| 2003 |
Cartegni L, Krainer AR. Correction of disease-associated exon skipping by synthetic exon-specific activators. Nature Structural Biology. 10: 120-5. PMID 12524529 DOI: 10.1038/Nsb887 |
0.534 |
|
| 2002 |
Hou VC, Lersch R, Gee SL, Ponthier JL, Lo AJ, Wu M, Turck CW, Koury M, Krainer AR, Mayeda A, Conboy JG. Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch. The Embo Journal. 21: 6195-204. PMID 12426391 DOI: 10.1093/Emboj/Cdf625 |
0.463 |
|
| 2002 |
Cazalla D, Zhu J, Manche L, Huber E, Krainer AR, Cáceres JF. Nuclear export and retention signals in the RS domain of SR proteins. Molecular and Cellular Biology. 22: 6871-82. PMID 12215544 DOI: 10.1128/Mcb.22.19.6871-6882.2002 |
0.641 |
|
| 2002 |
Fackenthal JD, Cartegni L, Krainer AR, Olopade OI. BRCA2 T2722R is a deleterious allele that causes exon skipping. American Journal of Human Genetics. 71: 625-31. PMID 12145750 DOI: 10.1086/342192 |
0.338 |
|
| 2002 |
Cartegni L, Chew SL, Krainer AR. Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nature Reviews. Genetics. 3: 285-98. PMID 11967553 DOI: 10.1038/Nrg775 |
0.408 |
|
| 2002 |
Cartegni L, Krainer AR. Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1. Nature Genetics. 30: 377-84. PMID 11925564 DOI: 10.1038/Ng854 |
0.405 |
|
| 2002 |
Vitali J, Ding J, Jiang J, Zhang Y, Krainer AR, Xu RM. Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Research. 30: 1531-8. PMID 11917013 DOI: 10.1093/Nar/30.7.1531 |
0.421 |
|
| 2002 |
Pollard AJ, Krainer AR, Robson SC, Europe-Finner GN. Alternative splicing of the adenylyl cyclase stimulatory G-protein G alpha(s) is regulated by SF2/ASF and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and involves the use of an unusual TG 3'-splice Site. The Journal of Biological Chemistry. 277: 15241-51. PMID 11825891 DOI: 10.1074/Jbc.M109046200 |
0.353 |
|
| 2002 |
Dance GS, Sowden MP, Cartegni L, Cooper E, Krainer AR, Smith HC. Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. The Journal of Biological Chemistry. 277: 12703-9. PMID 11815617 DOI: 10.1074/Jbc.M111337200 |
0.531 |
|
| 2002 |
Smith PJ, Spurrell EL, Coakley J, Hinds CJ, Ross RJ, Krainer AR, Chew SL. An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor. Endocrinology. 143: 146-54. PMID 11751603 DOI: 10.1210/Endo.143.1.8598 |
0.538 |
|
| 2001 |
Zhu J, Mayeda A, Krainer AR. Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. Molecular Cell. 8: 1351-61. PMID 11779509 DOI: 10.1016/S1097-2765(01)00409-9 |
0.461 |
|
| 2001 |
Bilodeau PS, Domsic JK, Mayeda A, Krainer AR, Stoltzfus CM. RNA splicing at human immunodeficiency virus type 1 3' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element. Journal of Virology. 75: 8487-97. PMID 11507194 DOI: 10.1128/Jvi.75.18.8487-8497.2001 |
0.528 |
|
| 2001 |
Hastings ML, Krainer AR. Pre-mRNA splicing in the new millennium. Current Opinion in Cell Biology. 13: 302-9. PMID 11343900 DOI: 10.1016/S0955-0674(00)00212-X |
0.72 |
|
| 2001 |
Hastings ML, Krainer AR. Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. Rna (New York, N.Y.). 7: 471-82. PMID 11333026 DOI: 10.1017/S1355838201002552 |
0.742 |
|
| 2001 |
Estmer Nilsson C, Petersen-Mahrt S, Durot C, Shtrichman R, Krainer AR, Kleinberger T, Akusjärvi G. The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins. The Embo Journal. 20: 864-71. PMID 11179230 DOI: 10.1093/Emboj/20.4.864 |
0.407 |
|
| 2001 |
Liu HX, Cartegni L, Zhang MQ, Krainer AR. A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. Nature Genetics. 27: 55-8. PMID 11137998 DOI: 10.1038/83762 |
0.425 |
|
| 2000 |
Zhu J, Krainer AR. Pre-mRNA splicing in the absence of an SR protein RS domain. Genes & Development. 14: 3166-78. PMID 11124808 DOI: 10.1101/Gad.189500 |
0.466 |
|
| 2000 |
Eperon IC, Makarova OV, Mayeda A, Munroe SH, Cáceres JF, Hayward DG, Krainer AR. Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Molecular and Cellular Biology. 20: 8303-18. PMID 11046128 DOI: 10.1128/Mcb.20.22.8303-8318.2000 |
0.68 |
|
| 2000 |
Van Scoy S, Watakabe I, Krainer AR, Hearing J. Human p32: a coactivator for Epstein-Barr virus nuclear antigen-1-mediated transcriptional activation and possible role in viral latent cycle DNA replication. Virology. 275: 145-57. PMID 11017796 DOI: 10.1006/Viro.2000.0508 |
0.325 |
|
| 2000 |
Dirksen WP, Li X, Mayeda A, Krainer AR, Rottman FM. Mapping the SF2/ASF binding sites in the bovine growth hormone exonic splicing enhancer. The Journal of Biological Chemistry. 275: 29170-7. PMID 10880506 DOI: 10.1074/Jbc.M001126200 |
0.444 |
|
| 2000 |
Pollard AJ, Sparey C, Robson SC, Krainer AR, Europe-Finner GN. Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1B in the myometrium of the pregnant human uterus: a molecular mechanism for regulating regional protein isoform expression in vivo. The Journal of Clinical Endocrinology and Metabolism. 85: 1928-36. PMID 10843177 DOI: 10.1210/Jcem.85.5.6537 |
0.401 |
|
| 2000 |
Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M. NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. The Journal of Biological Chemistry. 275: 25411-7. PMID 10827081 DOI: 10.1074/Jbc.M001676200 |
0.447 |
|
| 2000 |
van der Houven van Oordt W, Diaz-Meco MT, Lozano J, Krainer AR, Moscat J, Cáceres JF. The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. The Journal of Cell Biology. 149: 307-16. PMID 10769024 DOI: 10.1083/Jcb.149.2.307 |
0.691 |
|
| 2000 |
Liu HX, Chew SL, Cartegni L, Zhang MQ, Krainer AR. Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Molecular and Cellular Biology. 20: 1063-71. PMID 10629063 DOI: 10.1128/Mcb.20.3.1063-1071.2000 |
0.414 |
|
| 1999 |
Burns CG, Ohi R, Krainer AR, Gould KL. Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 96: 13789-94. PMID 10570151 DOI: 10.1073/Pnas.96.24.13789 |
0.5 |
|
| 1999 |
Mayeda A, Krainer AR. Mammalian in vitro splicing assays. Methods in Molecular Biology (Clifton, N.J.). 118: 315-21. PMID 10549534 DOI: 10.1385/1-59259-676-2:315 |
0.361 |
|
| 1999 |
Mayeda A, Krainer AR. Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods in Molecular Biology (Clifton, N.J.). 118: 309-14. PMID 10549533 DOI: 10.1385/1-59259-676-2:309 |
0.432 |
|
| 1999 |
Chew SL, Liu HX, Mayeda A, Krainer AR. Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 96: 10655-60. PMID 10485881 DOI: 10.1073/Pnas.96.19.10655 |
0.515 |
|
| 1999 |
Ismaïli N, Pérez-Morga D, Walsh P, Mayeda A, Pays A, Tebabi P, Krainer AR, Pays E. Characterization of a SR protein from Trypanosoma brucei with homology to RNA-binding cis-splicing proteins. Molecular and Biochemical Parasitology. 102: 103-15. PMID 10477180 DOI: 10.1016/S0166-6851(99)00091-2 |
0.5 |
|
| 1999 |
Mayeda A, Badolato J, Kobayashi R, Zhang MQ, Gardiner EM, Krainer AR. Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. The Embo Journal. 18: 4560-70. PMID 10449421 DOI: 10.1093/Emboj/18.16.4560 |
0.546 |
|
| 1999 |
Caputi M, Mayeda A, Krainer AR, Zahler AM. hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing. The Embo Journal. 18: 4060-7. PMID 10406810 DOI: 10.1093/Emboj/18.14.4060 |
0.429 |
|
| 1999 |
Ding J, Hayashi MK, Zhang Y, Manche L, Krainer AR, Xu RM. Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes & Development. 13: 1102-15. PMID 10323862 DOI: 10.1101/Gad.13.9.1102 |
0.397 |
|
| 1999 |
Lopato S, Kalyna M, Dorner S, Kobayashi R, Krainer AR, Barta A. atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes. Genes & Development. 13: 987-1001. PMID 10215626 DOI: 10.1101/Gad.13.8.987 |
0.448 |
|
| 1999 |
Wu Q, Krainer AR. AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Molecular and Cellular Biology. 19: 3225-36. PMID 10207048 DOI: 10.1128/Mcb.19.5.3225 |
0.628 |
|
| 1999 |
Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). The Journal of Biological Chemistry. 274: 11125-31. PMID 10196197 DOI: 10.1074/Jbc.274.16.11125 |
0.398 |
|
| 1999 |
Mayeda A, Screaton GR, Chandler SD, Fu XD, Krainer AR. Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements. Molecular and Cellular Biology. 19: 1853-63. PMID 10022872 DOI: 10.1128/Mcb.19.3.1853 |
0.529 |
|
| 1999 |
Murray MV, Kobayashi R, Krainer AR. The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. Genes & Development. 13: 87-97. PMID 9887102 DOI: 10.1101/Gad.13.1.87 |
0.466 |
|
| 1999 |
Krainer AR, Liu H, Chew S, Mayeda A. Finding exons in a sea of introns: the nature and function of exonic splicing enhancers Biochemistry and Cell Biology. 77: 398-399. DOI: 10.1139/O99-903R |
0.41 |
|
| 1998 |
Wu Q, Krainer AR. Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP. Rna (New York, N.Y.). 4: 1664-73. PMID 9848661 DOI: 10.1017/S1355838298981432 |
0.456 |
|
| 1998 |
Misteli T, Cáceres JF, Clement JQ, Krainer AR, Wilkinson MF, Spector DL. Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. The Journal of Cell Biology. 143: 297-307. PMID 9786943 DOI: 10.1083/Jcb.143.2.297 |
0.746 |
|
| 1998 |
Mayeda A, Munroe SH, Xu RM, Krainer AR. Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1. Rna (New York, N.Y.). 4: 1111-23. PMID 9740129 DOI: 10.1017/S135583829898089X |
0.478 |
|
| 1998 |
Liu HX, Zhang M, Krainer AR. Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes & Development. 12: 1998-2012. PMID 9649504 DOI: 10.1101/Gad.12.13.1998 |
0.461 |
|
| 1998 |
Hanamura A, Cáceres JF, Mayeda A, Franza BR, Krainer AR. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. Rna (New York, N.Y.). 4: 430-44. PMID 9630249 |
0.706 |
|
| 1998 |
Cáceres JF, Screaton GR, Krainer AR. A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes & Development. 12: 55-66. PMID 9420331 DOI: 10.1101/Gad.12.1.55 |
0.716 |
|
| 1997 |
Jokan L, Dong AP, Mayeda A, Krainer AR, Xu RM. Crystallization and preliminary X-ray diffraction studies of UP1, the two-RRM domain of hnRNP A1. Acta Crystallographica. Section D, Biological Crystallography. 53: 615-8. PMID 15299896 DOI: 10.1107/S0907444997003326 |
0.37 |
|
| 1997 |
Cáceres JF, Misteli T, Screaton GR, Spector DL, Krainer AR. Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. The Journal of Cell Biology. 138: 225-38. PMID 9230067 DOI: 10.1083/Jcb.138.2.225 |
0.687 |
|
| 1997 |
Huang S, Mayeda A, Krainer AR, Spector DL. RCC1 and nuclear organization. Molecular Biology of the Cell. 8: 1143-57. PMID 9201722 DOI: 10.1091/Mbc.8.6.1143 |
0.418 |
|
| 1997 |
Wu Q, Krainer AR. Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs. Rna (New York, N.Y.). 3: 586-601. PMID 9174094 |
0.31 |
|
| 1997 |
Xu RM, Jokhan L, Cheng X, Mayeda A, Krainer AR. Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure (London, England : 1993). 5: 559-70. PMID 9115444 DOI: 10.1016/S0969-2126(97)00211-6 |
0.483 |
|
| 1997 |
Chandler SD, Mayeda A, Yeakley JM, Krainer AR, Fu XD. RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. Proceedings of the National Academy of Sciences of the United States of America. 94: 3596-601. PMID 9108022 DOI: 10.1073/Pnas.94.8.3596 |
0.645 |
|
| 1997 |
Basu A, Dong B, Krainer AR, Howe CC. The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO. Molecular and Cellular Biology. 17: 677-86. PMID 9001221 DOI: 10.1128/Mcb.17.2.677 |
0.441 |
|
| 1997 |
Horowitz DS, Krainer AR. A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. Genes & Development. 11: 139-51. PMID 9000057 DOI: 10.1101/Gad.11.1.139 |
0.51 |
|
| 1996 |
Wu Q, Krainer AR. U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science (New York, N.Y.). 274: 1005-8. PMID 8875927 DOI: 10.1126/Science.274.5289.1005 |
0.629 |
|
| 1996 |
Lopato S, Mayeda A, Krainer AR, Barta A. Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors. Proceedings of the National Academy of Sciences of the United States of America. 93: 3074-9. PMID 8610170 DOI: 10.1073/Pnas.93.7.3074 |
0.414 |
|
| 1995 |
Screaton GR, Cáceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. The Embo Journal. 14: 4336-49. PMID 7556075 DOI: 10.1002/J.1460-2075.1995.Tb00108.X |
0.715 |
|
| 1994 |
O'Keefe RT, Mayeda A, Sadowski CL, Krainer AR, Spector DL. Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. The Journal of Cell Biology. 124: 249-60. PMID 8294510 DOI: 10.1083/Jcb.124.3.249 |
0.453 |
|
| 1994 |
Huang M, Rech JE, Northington SJ, Flicker PF, Mayeda A, Krainer AR, LeStourgeon WM. The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles. Molecular and Cellular Biology. 14: 518-33. PMID 8264621 DOI: 10.1128/Mcb.14.1.518 |
0.465 |
|
| 1994 |
Horowitz DS, Krainer AR. Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing. Trends in Genetics : Tig. 10: 100-6. PMID 8178363 DOI: 10.1016/0168-9525(94)90233-X |
0.478 |
|
| 1994 |
Cáceres JF, Stamm S, Helfman DM, Krainer AR. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (New York, N.Y.). 265: 1706-9. PMID 8085156 DOI: 10.1126/Science.8085156 |
0.699 |
|
| 1994 |
Mayeda A, Munroe SH, Cáceres JF, Krainer AR. Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. The Embo Journal. 13: 5483-95. PMID 7957114 DOI: 10.1002/J.1460-2075.1994.Tb06883.X |
0.717 |
|
| 1993 |
Mayeda A, Helfman DM, Krainer AR. Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Molecular and Cellular Biology. 13: 2993-3001. PMID 8474457 DOI: 10.1128/Mcb.13.5.2993 |
0.467 |
|
| 1993 |
Dong B, Horowitz DS, Kobayashi R, Krainer AR. Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids Research. 21: 4085-92. PMID 8371983 DOI: 10.1093/Nar/21.17.4085 |
0.515 |
|
| 1993 |
Birney E, Kumar S, Krainer AR. Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Research. 21: 5803-16. PMID 8290338 DOI: 10.1093/Nar/21.25.5803 |
0.531 |
|
| 1993 |
Sun Q, Mayeda A, Hampson RK, Krainer AR, Rottman FM. General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes & Development. 7: 2598-608. PMID 8276242 DOI: 10.1101/Gad.7.12B.2598 |
0.488 |
|
| 1993 |
Eperon IC, Ireland DC, Smith RA, Mayeda A, Krainer AR. Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. The Embo Journal. 12: 3607-17. PMID 8253084 DOI: 10.1002/J.1460-2075.1993.Tb06034.X |
0.425 |
|
| 1993 |
Cáceres JF, Krainer AR. Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. The Embo Journal. 12: 4715-26. PMID 8223480 DOI: 10.1002/J.1460-2075.1993.Tb06160.X |
0.74 |
|
| 1992 |
Mayeda A, Zahler AM, Krainer AR, Roth MB. Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 89: 1301-4. PMID 1741384 DOI: 10.1073/Pnas.89.4.1301 |
0.501 |
|
| 1992 |
Mayeda A, Krainer AR. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell. 68: 365-75. PMID 1531115 DOI: 10.1016/0092-8674(92)90477-T |
0.52 |
|
| 1992 |
Fu XD, Mayeda A, Maniatis T, Krainer AR. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proceedings of the National Academy of Sciences of the United States of America. 89: 11224-8. PMID 1454802 DOI: 10.1073/Pnas.89.23.11224 |
0.781 |
|
| 1992 |
Amero SA, Raychaudhuri G, Cass CL, van Venrooij WJ, Habets WJ, Krainer AR, Beyer AL. Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. Proceedings of the National Academy of Sciences of the United States of America. 89: 8409-13. PMID 1388268 DOI: 10.1073/Pnas.89.18.8409 |
0.44 |
|
| 1991 |
Krainer AR, Mayeda A, Kozak D, Binns G. Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell. 66: 383-94. PMID 1830244 DOI: 10.1016/0092-8674(91)90627-B |
0.534 |
|
| 1990 |
Krainer AR, Conway GC, Kozak D. The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites. Cell. 62: 35-42. PMID 2364434 DOI: 10.1016/0092-8674(90)90237-9 |
0.506 |
|
| 1990 |
Krainer AR, Conway GC, Kozak D. Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Genes & Development. 4: 1158-71. PMID 2145194 DOI: 10.1101/Gad.4.7.1158 |
0.528 |
|
| 1989 |
Conway GC, Krainer AR, Spector DL, Roberts RJ. Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing. Molecular and Cellular Biology. 9: 5273-80. PMID 2531283 DOI: 10.1128/mcb.9.12.5273-5280.1989 |
0.427 |
|
| 1988 |
Krainer AR. Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPs. Nucleic Acids Research. 16: 9415-29. PMID 3141901 DOI: 10.1093/Nar/16.20.9415 |
0.397 |
|
| 1988 |
Tschudi C, Krainer AR, Ullu E. The U6 small nuclear RNA from Trypanosoma brucei. Nucleic Acids Research. 16: 11375. PMID 3060859 DOI: 10.1093/Nar/16.23.11375 |
0.38 |
|
| 1985 |
Krainer AR, Maniatis T. Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell. 42: 725-36. PMID 2996774 DOI: 10.1016/0092-8674(85)90269-7 |
0.699 |
|
| 1984 |
Krainer AR, Maniatis T, Ruskin B, Green MR. Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell. 36: 993-1005. PMID 6323033 DOI: 10.1016/0092-8674(84)90049-7 |
0.721 |
|
| 1984 |
Ruskin B, Krainer AR, Maniatis T, Green MR. Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell. 38: 317-31. PMID 6088074 DOI: 10.1016/0092-8674(84)90553-1 |
0.702 |
|
| 1982 |
Squires C, Krainer A, Barry G, Shen WF, Squires CL. Nucleotide sequence at the end of the gene for the RNA polymerase beta' subunit (rpoC). Nucleic Acids Research. 9: 6827-40. PMID 6278450 DOI: 10.1093/Nar/9.24.6827 |
0.448 |
|
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