James E. Klaunig - Publications

Affiliations: 
Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Toxicology, Oncology, Molecular Biology

152 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Li X, Wang Z, Wu Q, Klaunig JE. Evaluating the mode of action of perfluorooctanoic acid-induced liver tumors in male Sprague-Dawley rats using a toxicogenomic approach. Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis. 1-25. PMID 38494990 DOI: 10.1080/26896583.2024.2327969  0.336
2020 Wang Z, Wu Q, Li X, Klaunig JE. Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse. Archives of Toxicology. PMID 32435917 DOI: 10.1007/S00204-020-02781-8  0.412
2020 Dunn KW, Martinez MM, Wang Z, Mang HE, Clendenon SG, Sluka JP, Glazier JA, Klaunig JE. Mitochondrial depolarization and repolarization in the early stages of acetaminophen hepatotoxicity in mice. Toxicology. 152464. PMID 32315716 DOI: 10.1016/J.Tox.2020.152464  0.328
2020 Chappell GA, Thompson CM, Wolf JC, Cullen JM, Klaunig JE, Haws LC. Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks. Toxicologic Pathology. 192623320905803. PMID 32138627 DOI: 10.1177/0192623320905803  0.37
2020 Klaunig JE, Melo L, Tilmant K. Mechanisms of hepatic cancer by persistent organic pollutants Current Opinion in Toxicology. 19: 105-111. DOI: 10.1016/J.Cotox.2020.02.001  0.328
2019 Nault R, Bals B, Teymouri F, Black MB, Andersen ME, McMullen PD, Krishnan S, Kuravadi N, Paul N, Kumar S, Kannan K, Jayachandra KC, Alagappan L, Patel BD, Bogen KT, ... ... Klaunig JE, et al. A toxicogenomic approach for the risk assessment of the food contaminant acetamide. Toxicology and Applied Pharmacology. 114872. PMID 31881176 DOI: 10.1016/J.Taap.2019.114872  0.358
2019 Zeng R, Wang X, Zhou Q, Fu X, Wu Q, Lu Y, Shi J, Klaunig JE, Zhou S. Icariin protects rotenone-induced neurotoxicity through induction of SIRT3. Toxicology and Applied Pharmacology. 114639. PMID 31251943 DOI: 10.1016/J.Taap.2019.114639  0.335
2019 Li X, Wang Z, Klaunig JE. The effects of perfluorooctanoate on high fat diet induced non-alcoholic fatty liver disease in mice. Toxicology. PMID 30711707 DOI: 10.1016/J.Tox.2019.01.017  0.388
2018 Fu X, Sluka JP, Clendenon SG, Dunn KW, Wang Z, Klaunig JE, Glazier JA. Modeling of xenobiotic transport and metabolism in virtual hepatic lobule models. Plos One. 13: e0198060. PMID 30212461 DOI: 10.1371/Journal.Pone.0198060  0.324
2018 Li X, Wang Z, Klaunig JE. Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease. Toxicology. PMID 30120929 DOI: 10.1016/J.Tox.2018.08.007  0.347
2018 Klaunig JE, Li X, Wang Z. Role of xenobiotics in the induction and progression of fatty liver disease. Toxicology Research. 7: 664-680. PMID 30090613 DOI: 10.1039/C7Tx00326A  0.356
2018 Chowdhury A, Arnold LL, Wang Z, Pennington KL, Dodmane P, Farragut-Cardoso AP, Klaunig JE, Cros D, Creppy EE, Cohen SM. Effect of Polyhexamethylene Biguanide on Rat Liver. Toxicology Letters. PMID 29305328 DOI: 10.1016/J.Toxlet.2017.12.032  0.369
2018 Klaunig JE, Wang Z. Oxidative stress in carcinogenesis Current Opinion in Toxicology. 7: 116-121. DOI: 10.1016/J.Cotox.2017.11.014  0.342
2017 Zhou Q, Fu X, Wang X, Wu Q, Lu Y, Shi J, Klaunig JE, Zhou S. Autophagy plays a protective role in Mn-induced toxicity in PC12 cells. Toxicology. 394: 45-53. PMID 29222055 DOI: 10.1016/J.Tox.2017.12.001  0.355
2017 Corton JC, Peters JM, Klaunig JE. The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions. Archives of Toxicology. PMID 29197930 DOI: 10.1007/S00204-017-2094-7  0.422
2017 Felter SP, Foreman JE, Boobis A, Corton JC, Doi AM, Flowers L, Goodman J, Haber LT, Jacobs A, Klaunig JE, Lynch AM, Moggs J, Pandiri A. Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action. Regulatory Toxicology and Pharmacology : Rtp. PMID 29113941 DOI: 10.1016/J.Yrtph.2017.11.003  0.326
2017 Coskran TM, Jiang Z, Klaunig JE, Mager DL, Obert L, Robertson A, Tsinoremas N, Wang Z, Gosink M. Induction of endogenous retroelements as a potential mechanism for mouse-specific drug-induced carcinogenicity. Plos One. 12: e0176768. PMID 28472135 DOI: 10.1371/Journal.Pone.0176768  0.346
2017 Wang Z, Li X, Klaunig JE. Investigation of the mechanism of triclosan induced liver tumors in mouse. Regulatory Toxicology and Pharmacology : Rtp. PMID 28267557 DOI: 10.1016/J.Yrtph.2017.03.001  0.411
2017 Wang Z, Li X, Wu Q, Lamb JC, Klaunig JE. Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor. Journal of Applied Toxicology : Jat. PMID 28218408 DOI: 10.1002/Jat.3445  0.37
2017 Dekant W, Scialli AR, Plotzke K, Klaunig JE. Biological relevance of effects following chronic administration of octamethylcyclotetrasiloxane (D4) in Fischer 344 rats. Toxicology Letters. PMID 28109826 DOI: 10.1016/J.Toxlet.2017.01.010  0.341
2016 Pu X, Wang Z, Klaunig JE. Cryopreservation of human blood for alkaline and Fpg-modified comet assay. Toxicology Mechanisms and Methods. 1-6. PMID 26982377 DOI: 10.3109/15376516.2016.1144126  0.304
2016 Klaunig JE, Dekant W, Plotzke K, Scialli AR. Biological relevance of decamethylcyclopentasiloxane (D5) induced rat uterine endometrial adenocarcinoma tumorigenesis: Mode of action and relevance to humans. Regulatory Toxicology and Pharmacology : Rtp. 74: S44-56. PMID 26148665 DOI: 10.1016/J.Yrtph.2015.06.021  0.304
2016 Dekant W, Klaunig JE. Toxicology of decamethylcyclopentasiloxane (D5). Regulatory Toxicology and Pharmacology : Rtp. 74: S67-76. PMID 26111607 DOI: 10.1016/J.Yrtph.2015.06.011  0.327
2015 Pu X, Wang Z, Zhou S, Klaunig JE. Protective effects of antioxidants on acrylonitrile-induced oxidative stress in female F344 rats. Environmental Toxicology. PMID 26332274 DOI: 10.1002/Tox.22182  0.388
2015 Wang Z, Neal BH, Lamb JC, Klaunig JE. Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors. Toxicological Sciences : An Official Journal of the Society of Toxicology. 147: 549-61. PMID 26187448 DOI: 10.1093/Toxsci/Kfv151  0.428
2015 Engström W, Darbre P, Eriksson S, Gulliver L, Hultman T, Karamouzis MV, Klaunig JE, Mehta R, Moorwood K, Sanderson T, Sone H, Vadgama P, Wagemaker G, Ward A, Singh N, et al. The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Carcinogenesis. 36: S38-60. PMID 26106143 DOI: 10.1093/Carcin/Bgv030  0.309
2015 Klaunig JE, Gehen SC, Wang Z, Klein PJ, Billington R. Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 143: 6-15. PMID 25354764 DOI: 10.1093/Toxsci/Kfu221  0.366
2014 Wang ZY, Burlak C, Klaunig JE, Kamendulis LM. Development of a cytokine-producing immortalized murine Kupffer cell line. Cytokine. 70: 165-72. PMID 25138015 DOI: 10.1016/J.Cyto.2014.07.251  0.353
2014 Hocevar BA, Kamendulis LM, Pu X, Perkins SM, Wang ZY, Johnston EL, DeWitt JM, Li L, Loehrer PJ, Klaunig JE, Chiorean EG. Contribution of environment and genetics to pancreatic cancer susceptibility. Plos One. 9: e90052. PMID 24651674 DOI: 10.1371/Journal.Pone.0090052  0.306
2014 Corton JC, Cunningham ML, Hummer BT, Lau C, Meek B, Peters JM, Popp JA, Rhomberg L, Seed J, Klaunig JE. Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study. Critical Reviews in Toxicology. 44: 1-49. PMID 24180432 DOI: 10.3109/10408444.2013.835784  0.389
2014 Owumi SE, Corthals SM, Uwaifo AO, Kamendulis LM, Klaunig JE. Depletion of Kupffer cells modulates ethanol-induced hepatocyte DNA synthesis in C57Bl/6 mice. Environmental Toxicology. 29: 867-75. PMID 22996800 DOI: 10.1002/Tox.21814  0.391
2012 Stagg NJ, LeBaron MJ, Eisenbrandt DL, Gollapudi BB, Klaunig JE. Assessment of possible carcinogenicity of oxyfluorfen to humans using mode of action analysis of rodent liver effects. Toxicological Sciences : An Official Journal of the Society of Toxicology. 128: 334-45. PMID 22539621 DOI: 10.1093/Toxsci/Kfs157  0.423
2012 Klaunig JE, Hocevar BA, Kamendulis LM. Mode of Action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and Human Relevance. Reproductive Toxicology (Elmsford, N.Y.). 33: 410-8. PMID 22120428 DOI: 10.1016/J.Reprotox.2011.10.014  0.332
2011 Hocevar BA, Chiorean EG, Kamendulis L, Perkins SM, Johnston EL, DeWitt J, Li L, Klaunig JE. Contribution of environment and genetics to oxidative stress in pancreatic cancer (PC) patients (pts). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 211. PMID 27985913 DOI: 10.1200/Jco.2011.29.4_Suppl.211  0.307
2011 Vuppalanchi R, Juluri R, Bell LN, Ghabril M, Kamendulis L, Klaunig JE, Saxena R, Agarwal D, Johnson MS, Chalasani N. Oxidative stress in chronic liver disease: relationship between peripheral and hepatic measurements. The American Journal of the Medical Sciences. 342: 314-7. PMID 21691193 DOI: 10.1097/Maj.0B013E31821D9905  0.332
2011 Kushida M, Kamendulis LM, Peat TJ, Klaunig JE. Dose-related induction of hepatic preneoplastic lesions by diethylnitrosamine in C57BL/6 mice. Toxicologic Pathology. 39: 776-86. PMID 21628716 DOI: 10.1177/0192623311409596  0.316
2011 Klaunig JE, Wang Z, Pu X, Zhou S. Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicology and Applied Pharmacology. 254: 86-99. PMID 21296097 DOI: 10.1016/J.Taap.2009.11.028  0.357
2011 Shanmugam R, Kusumanchi P, Appaiah H, Cheng L, Crooks P, Neelakantan S, Peat T, Klaunig J, Matthews W, Nakshatri H, Sweeney CJ. A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species. International Journal of Cancer. Journal International Du Cancer. 128: 2481-94. PMID 20669221 DOI: 10.1002/Ijc.25587  0.336
2010 Zhang XF, Tan X, Zeng G, Misse A, Singh S, Kim Y, Klaunig JE, Monga SP. Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Hepatology (Baltimore, Md.). 52: 954-65. PMID 20583210 DOI: 10.1002/Hep.23747  0.344
2010 Kamendulis LM, Corthals SM, Klaunig JE. Kupffer cells participate in 2-butoxyethanol-induced liver hemangiosarcomas. Toxicology. 270: 131-6. PMID 20153399 DOI: 10.1016/J.Tox.2010.02.006  0.412
2010 Meek ME, Klaunig JE. Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment. Chemico-Biological Interactions. 184: 279-85. PMID 20153303 DOI: 10.1016/J.Cbi.2010.02.006  0.325
2010 Klaunig JE, Kamendulis LM, Hocevar BA. Oxidative stress and oxidative damage in carcinogenesis. Toxicologic Pathology. 38: 96-109. PMID 20019356 DOI: 10.1177/0192623309356453  0.346
2009 Harvilchuck JA, Pu X, Klaunig JE, Carlson GP. Indicators of oxidative stress and apoptosis in mouse whole lung and Clara cells following exposure to styrene and its metabolites. Toxicology. 264: 171-8. PMID 19666080 DOI: 10.1016/J.Tox.2009.08.001  0.374
2009 Pu X, Kamendulis LM, Klaunig JE. Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 111: 64-71. PMID 19546159 DOI: 10.1093/Toxsci/Kfp133  0.375
2009 Cohen SM, Storer RD, Criswell KA, Doerrer NG, Dellarco VL, Pegg DG, Wojcinski ZW, Malarkey DE, Jacobs AC, Klaunig JE, Swenberg JA, Cook JC. Hemangiosarcoma in rodents: mode-of-action evaluation and human relevance. Toxicological Sciences : An Official Journal of the Society of Toxicology. 111: 4-18. PMID 19525443 DOI: 10.1093/Toxsci/Kfp131  0.342
2009 Klaunig J, Rice J. Genotoxicity and carcinogenicity of acrylamide Toxicology Letters. 189: S41. DOI: 10.1016/J.Toxlet.2009.06.130  0.329
2008 de Peyster A, Rodriguez Y, Shuto R, Goldberg B, Gonzales F, Pu X, Klaunig JE. Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver. Reproductive Toxicology (Elmsford, N.Y.). 26: 246-53. PMID 18824092 DOI: 10.1016/J.Reprotox.2008.08.009  0.372
2008 Novotny NM, Grosfeld JL, Turner KE, Rescorla FJ, Pu X, Klaunig JE, Hickey RJ, Malkas LH, Sandoval JA. Oxidative status in neuroblastoma: a source of stress? Journal of Pediatric Surgery. 43: 330-4. PMID 18280284 DOI: 10.1016/J.Jpedsurg.2007.10.040  0.395
2007 Roberts RA, Ganey PE, Ju C, Kamendulis LM, Rusyn I, Klaunig JE. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 96: 2-15. PMID 17122412 DOI: 10.1093/Toxsci/Kfl173  0.387
2007 Klaunig J. Kupffer cells and the hepatic response to toxicants Toxicology Letters. 172: S27-S28. DOI: 10.1016/J.Toxlet.2007.05.100  0.33
2006 Pu X, Kamendulis LM, Klaunig JE. Acrylonitrile-induced oxidative DNA damage in rat astrocytes. Environmental and Molecular Mutagenesis. 47: 631-8. PMID 16917936 DOI: 10.1002/Em.20249  0.358
2006 Corthals SM, Kamendulis LM, Klaunig JE. Mechanisms of 2-butoxyethanol-induced hemangiosarcomas. Toxicological Sciences : An Official Journal of the Society of Toxicology. 92: 378-86. PMID 16675516 DOI: 10.1093/Toxsci/Kfl007  0.379
2006 Holsapple MP, Pitot HC, Cohen SM, Cohen SH, Boobis AR, Klaunig JE, Pastoor T, Dellarco VL, Dragan YP. Mode of action in relevance of rodent liver tumors to human cancer risk. Toxicological Sciences : An Official Journal of the Society of Toxicology. 89: 51-6. PMID 16221960 DOI: 10.1093/Toxsci/Kfj001  0.35
2005 Klaunig JE, Kamendulis LM. Mechanisms of acrylamide induced rodent carcinogenesis. Advances in Experimental Medicine and Biology. 561: 49-62. PMID 16438288 DOI: 10.1007/0-387-24980-X_4  0.393
2005 Klaunig JE. Cancer biology and hormesis: commentary. Critical Reviews in Toxicology. 35: 593-4. PMID 16422395 DOI: 10.1080/10408440500246827  0.323
2005 Kirman CR, Gargas ML, Marsh GM, Strother DE, Klaunig JE, Collins JJ, Deskin R. Cancer dose--response assessment for acrylonitrile based upon rodent brain tumor incidence: use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity. Regulatory Toxicology and Pharmacology : Rtp. 43: 85-103. PMID 16099568 DOI: 10.1016/J.Yrtph.2005.06.007  0.34
2005 Kamendulis LM, Klaunig JE. Species differences in the induction of hepatocellular DNA synthesis by diethanolamine. Toxicological Sciences : An Official Journal of the Society of Toxicology. 87: 328-36. PMID 16014740 DOI: 10.1093/Toxsci/Kfi252  0.414
2005 Klaunig JE, Kamendulis LM. Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas. Toxicology Letters. 156: 107-15. PMID 15705491 DOI: 10.1016/J.Toxlet.2003.08.012  0.457
2004 Lafferty JS, Kamendulis LM, Kaster J, Jiang J, Klaunig JE. Subchronic acrylamide treatment induces a tissue-specific increase in DNA synthesis in the rat. Toxicology Letters. 154: 95-103. PMID 15475183 DOI: 10.1016/J.Toxlet.2004.07.008  0.367
2004 Boatman R, Corley R, Green T, Klaunig J, Udden M. Review of studies concerning the tumorigenicity of 2-butoxyethanol in B6C3F1 mice and its relevance for human risk assessment. Journal of Toxicology and Environmental Health. Part B, Critical Reviews. 7: 385-98. PMID 15371241 DOI: 10.1080/10937400490498084  0.418
2004 Rusyniak DE, Tandy SL, Kamendulis LM, Sprague JE, Klaunig JE. The effects of ecstasy (MDMA) on rat liver bioenergetics. Academic Emergency Medicine : Official Journal of the Society For Academic Emergency Medicine. 11: 723-9. PMID 15231458 DOI: 10.1197/J.Aem.2004.03.004  0.349
2004 Klaunig JE, Kamendulis LM. The role of oxidative stress in carcinogenesis. Annual Review of Pharmacology and Toxicology. 44: 239-67. PMID 14744246 DOI: 10.1146/Annurev.Pharmtox.44.101802.121851  0.341
2003 Klaunig JE, Babich MA, Baetcke KP, Cook JC, Corton JC, David RM, DeLuca JG, Lai DY, McKee RH, Peters JM, Roberts RA, Fenner-Crisp PA. PPARalpha agonist-induced rodent tumors: modes of action and human relevance. Critical Reviews in Toxicology. 33: 655-780. PMID 14727734 DOI: 10.1080/713608372  0.411
2002 Siesky AM, Kamendulis LM, Klaunig JE. Hepatic effects of 2-butoxyethanol in rodents. Toxicological Sciences : An Official Journal of the Society of Toxicology. 70: 252-60. PMID 12441370 DOI: 10.1093/Toxsci/70.2.252  0.439
2002 Kamendulis LM, Zhang H, Wang Y, Klaunig JE. Morphological transformation and oxidative stress induced by cyanide in Syrian hamster embryo (SHE) cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 68: 437-43. PMID 12151639 DOI: 10.1093/Toxsci/68.2.437  0.677
2002 Park J, Kamendulis LM, Klaunig JE. Mechanisms of 2-butoxyethanol carcinogenicity: studies on Syrian Hamster Embryo (SHE) cell transformation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 68: 43-50. PMID 12075109 DOI: 10.1093/Toxsci/68.1.43  0.442
2002 Zhang H, Kamendulis LM, Klaunig JE. Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile. Toxicological Sciences : An Official Journal of the Society of Toxicology. 67: 247-55. PMID 12011484 DOI: 10.1093/Toxsci/67.2.247  0.683
2002 Kamendulis LM, Isenberg JS, Smith JH, Pugh G, Lington AW, Klaunig JE. Comparative effects of phthalate monoesters on gap junctional intercellular communication and peroxisome proliferation in rodent and primate hepatocytes. Journal of Toxicology and Environmental Health. Part A. 65: 569-88. PMID 11995694 DOI: 10.1080/152873902317349736  0.407
2002 Park J, Kamendulis LM, Friedman MA, Klaunig JE. Acrylamide-induced cellular transformation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 65: 177-83. PMID 11812921 DOI: 10.1093/Toxsci/65.2.177  0.373
2002 Park J, Kamendulis LM, Klaunig JE. Effects of 2-butoxyethanol on hepatic oxidative damage. Toxicology Letters. 126: 19-29. PMID 11738267 DOI: 10.1016/S0378-4274(01)00434-9  0.439
2001 Isenberg JS, Kamendulis LM, Ackley DC, Smith JH, Pugh G, Lington AW, McKee RH, Klaunig JE. Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents. Toxicological Sciences : An Official Journal of the Society of Toxicology. 64: 192-9. PMID 11719701 DOI: 10.1093/Toxsci/64.2.192  0.43
2001 Gottschling BC, Maronpot RR, Hailey JR, Peddada S, Moomaw CR, Klaunig JE, Nyska A. The role of oxidative stress in indium phosphide-induced lung carcinogenesis in rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 64: 28-40. PMID 11606799 DOI: 10.1093/Toxsci/64.1.28  0.339
2001 Klaunig JE, Kamendulis LM, Xu Y. Epigenetic mechanisms of chemical carcinogenesis. Human & Experimental Toxicology. 19: 543-55. PMID 11211991 DOI: 10.1191/096032700701546442  0.357
2001 Kamendulis LM, Kolaja KL, Stevenson DE, Walborg EF, Klaunig JE. Comparative effects of dieldrin on hepatic ploidy, cell proliferation, and apoptosis in rodent liver. Journal of Toxicology and Environmental Health. Part A. 62: 127-41. PMID 11209821 DOI: 10.1080/009841001455535  0.435
2000 Zhang H, Xu Y, Kamendulis LM, Klaunig JE. Morphological transformation by 8-hydroxy-2'-deoxyguanosine in Syrian hamster embryo (SHE) cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 56: 303-12. PMID 10910988 DOI: 10.1093/Toxsci/56.2.303  0.667
2000 Pugh G, Isenberg JS, Kamendulis LM, Ackley DC, Clare LJ, Brown R, Lington AW, Smith JH, Klaunig JE. Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys. Toxicological Sciences : An Official Journal of the Society of Toxicology. 56: 181-8. PMID 10869467 DOI: 10.1093/Toxsci/56.1.181  0.399
2000 Isenberg JS, Kamendulis LM, Smith JH, Ackley DC, Pugh G, Lington AW, Klaunig JE. Effects of Di-2-ethylhexyl phthalate (DEHP) on gap-junctional intercellular communication (GJIC), DNA synthesis, and peroxisomal beta oxidation (PBOX) in rat, mouse, and hamster liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 56: 73-85. PMID 10869455 DOI: 10.1093/Toxsci/56.1.73  0.42
2000 Smith JH, Isenberg JS, Pugh G, Kamendulis LM, Ackley D, Lington AW, Klaunig JE. Comparative in vivo hepatic effects of Di-isononyl phthalate (DINP) and related C7-C11 dialkyl phthalates on gap junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX), and DNA synthesis in rat and mouse liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 54: 312-21. PMID 10774813 DOI: 10.1093/Toxsci/54.2.312  0.423
2000 Zhang H, Kamendulis LM, Jiang J, Xu Y, Klaunig JE. Acrylonitrile-induced morphological transformation in Syrian hamster embryo cells. Carcinogenesis. 21: 727-33. PMID 10753209 DOI: 10.1093/Carcin/21.4.727  0.684
2000 Isenberg JS, Klaunig JE. Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 53: 340-51. PMID 10696782 DOI: 10.1093/Toxsci/53.2.340  0.33
1999 Kamendulis LM, Jiang J, Zhang H, deFeijter-Rupp H, Trosko JE, Klaunig JE. The effect of acrylonitrile on gap junctional intercellular communication in rat astrocytes. Cell Biology and Toxicology. 15: 173-83. PMID 10580550 DOI: 10.1023/A:1007685504941  0.672
1999 Stevenson DE, Walborg EF, North DW, Sielken RL, Ross CE, Wright AS, Xu Y, Kamendulis LM, Klaunig JE. Monograph: reassessment of human cancer risk of aldrin/dieldrin. Toxicology Letters. 109: 123-86. PMID 10555138 DOI: 10.1016/S0378-4274(99)00132-0  0.378
1999 Kamendulis LM, Jiang J, Xu Y, Klaunig JE. Induction of oxidative stress and oxidative damage in rat glial cells by acrylonitrile. Carcinogenesis. 20: 1555-60. PMID 10426806 DOI: 10.1093/Carcin/20.8.1555  0.432
1999 Klaunig JE, Xu Y, Han C, Kamendulis LM, Chen J, Heiser C, Gordon MS, Mohler ER. The effect of tea consumption on oxidative stress in smokers and nonsmokers. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 220: 249-54. PMID 10202398 DOI: 10.1046/J.1525-1373.1999.D01-43.X  0.341
1999 Jiang J, Xu Y, Klaunig JE. Induction of oxidative stress in rat brain by acrylonitrile (ACN). Toxicological Sciences : An Official Journal of the Society of Toxicology. 46: 333-41. PMID 10048137 DOI: 10.1006/Toxs.1998.2524  0.416
1999 Klaunig J. Mechanisms of cancer chemoprevention in hepatic carcinogenesis: modulation of focal lesion growth in mice Toxicological Sciences. 52: 101-106. DOI: 10.1093/Toxsci/52.Suppl_1.101  0.401
1998 Bachowski S, Xu Y, Stevenson DE, Walborg EF, Klaunig JE. Role of oxidative stress in the selective toxicity of dieldrin in the mouse liver. Toxicology and Applied Pharmacology. 150: 301-9. PMID 9653061 DOI: 10.1006/Taap.1998.8372  0.414
1998 Klaunig JE, Xu Y, Isenberg JS, Bachowski S, Kolaja KL, Jiang J, Stevenson DE, Walborg EF. The role of oxidative stress in chemical carcinogenesis. Environmental Health Perspectives. 106: 289-95. PMID 9539021 DOI: 10.1289/Ehp.98106S1289  0.396
1998 Dragan Y, klaunig J, Moronpot R, Goldsworthy T. Meeting Overview: Mechanisms of Susceptibility to Mouse Liver Carcinogenesis Toxicological Sciences. 41: 3-7. DOI: 10.1093/Toxsci/41.1.3  0.339
1997 Isenberg JS, Kolaja KL, Ayoubi SA, Watkins JB, Klaunig JE. Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone. Carcinogenesis. 18: 1511-9. PMID 9276624 DOI: 10.1093/Carcin/18.8.1511  0.329
1997 Kolaja KL, Klaunig JE. Vitamin E modulation of hepatic focal lesion growth in mice. Toxicology and Applied Pharmacology. 143: 380-7. PMID 9144454 DOI: 10.1006/Taap.1996.8089  0.307
1996 Kolaja KL, Bunting KA, Klaunig JE. Inhibition of tumor promotion and hepatocellular growth by dietary restriction in mice. Carcinogenesis. 17: 1657-64. PMID 8761422 DOI: 10.1093/Carcin/17.8.1657  0.351
1996 Kolaja KL, Stevenson DE, Johnson JT, Walborg EF, Klaunig JE. Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 29: 219-28. PMID 8742319 DOI: 10.1006/Faat.1996.0025  0.414
1996 Kolaja KL, Stevenson DE, Walborg EF, Klaunig JE. Reversibility of promoter induced hepatic focal lesion growth in mice. Carcinogenesis. 17: 1403-9. PMID 8706241 DOI: 10.1093/Carcin/17.7.1403  0.301
1996 Kolaja KL, Stevenson DE, Walborg EF, Klaunig JE. Selective dieldrin promotion of hepatic focal lesions in mice. Carcinogenesis. 17: 1243-50. PMID 8681438 DOI: 10.1093/Carcin/17.6.1243  0.383
1996 Kolaja KL, Stevenson DE, Walborg EF, Klaunig JE. Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis. Carcinogenesis. 17: 947-54. PMID 8640942 DOI: 10.1093/Carcin/17.5.947  0.394
1996 CAO J, XU Y, CHEN J, KLAUNIG JE. Chemopreventive Effects of Green and Black Tea on Pulmonary and Hepatic Carcinogenesis Toxicological Sciences. 29: 244-250. DOI: 10.1093/Toxsci/29.2.244  0.355
1995 Klaunig JE, Xu Y, Bachowski S, Ketcham CA, Isenberg JS, Kolaja KL, Baker TK, Walborg EF, Stevenson DE. Oxidative stress in nongenotoxic carcinogenesis. Toxicology Letters. 82: 683-91. PMID 8597127 DOI: 10.1016/0378-4274(95)03514-1  0.448
1995 Stevenson DE, Kehrer JP, Kolaja KL, Walborg EF, Klaunig JE. Effect of dietary antioxidants on dieldrin-induced hepatotoxicity in mice. Toxicology Letters. 75: 177-83. PMID 7863524 DOI: 10.1016/0378-4274(94)03178-A  0.387
1995 Jou YS, Layhe B, Matesic DF, Chang CC, de Feijter AW, Lockwood L, Welsch CW, Klaunig JE, Trosko JE. Inhibition of gap junctional intercellular communication and malignant transformation of rat liver epithelial cells by neu oncogene. Carcinogenesis. 16: 311-7. PMID 7859363 DOI: 10.1093/Carcin/16.2.311  0.39
1995 Baker TK, Kwiatkowski AP, Madhukar BV, Klaunig JE. Inhibition of gap junctional intercellular communication by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat hepatocytes. Carcinogenesis. 16: 2321-6. PMID 7586129 DOI: 10.1093/Carcin/16.10.2321  0.374
1995 Siglin JC, Weghorst CM, Rodwell DE, Klaunig JE. Gender-dependent differences in hepatic tumor promotion in diethylnitrosamine initiated infant B6C3F, mice by alpha-hexachlorocyclohexane Journal of Toxicology and Environmental Health. 44: 235-244. PMID 7531777 DOI: 10.1080/15287399509531957  0.341
1994 Kwiatkowski AP, Baker TK, Klaunig JE. Comparison of glucocorticoid-mediated changes in the expression and function of rat hepatocyte gap junctional proteins. Carcinogenesis. 15: 1753-7. PMID 8055659 DOI: 10.1093/Carcin/15.8.1753  0.319
1994 Klaunig JE. Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital. Environmental Health Perspectives. 235-9. PMID 8013413 DOI: 10.1289/Ehp.93101S5235  0.367
1993 Ruch RJ, Madhukar BV, Trosko JE, Klaunig JE. Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation, and tumorigenesis by lovastatin. Molecular Carcinogenesis. 7: 50-9. PMID 8435109 DOI: 10.1002/Mc.2940070109  0.315
1992 Goodman JI, Ward JM, Popp JA, Klaunig JE, Fox TR. Mouse liver carcinogenesis: mechanisms and relevance. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 17: 651-65. PMID 1685715 DOI: 10.1016/0272-0590(91)90175-4  0.34
1992 Klaunig JE. Chemopreventive effects of green tea components on hepatic carcinogenesis. Preventive Medicine. 21: 510-9. PMID 1409492 DOI: 10.1016/0091-7435(92)90058-P  0.441
1991 Ruch RJ, Bandyopadhyay S, Somani P, Klaunig JE. Evaluation of amiodarone free radical toxicity in rat hepatocytes. Toxicology Letters. 56: 117-26. PMID 2017769 DOI: 10.1016/0378-4274(91)90097-P  0.331
1991 Klaunig JE. Alterations in intercellular communication during the stage of promotion. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 198: 688-92. PMID 1924405 DOI: 10.3181/00379727-198-43308  0.38
1990 Bandyopadhyay S, Klaunig JE, Somani P. Cytotoxic interactions of cardioactive cationic amphiphilic compounds in primary rat hepatocytes in culture. Hepatology (Baltimore, Md.). 12: 48-58. PMID 2373484 DOI: 10.1002/Hep.1840120109  0.301
1990 Ruch RJ, Fransson R, Flodstrom S, Warngard L, Klaunig JE. Inhibition of hepatocyte gap junctional intercellular communication by endosulfan, chlordane and heptachlor. Carcinogenesis. 11: 1097-101. PMID 2372869 DOI: 10.1093/Carcin/11.7.1097  0.381
1990 Klaunig JE, Weghorst TR, Weghorst CM. Liver tumor promoting ability of corn oil gavage in B6C3F1 male mice Cancer Letters. 50: 215-219. PMID 2322934 DOI: 10.1016/0304-3835(90)90268-3  0.317
1990 Somani P, Bandyopadhyay S, Klaunig JE, Gross SA. Amiodarone- and desethylamiodarone-induced myelinoid inclusion bodies and toxicity in cultured rat hepatocytes. Hepatology (Baltimore, Md.). 11: 81-92. PMID 2153095 DOI: 10.1002/Hep.1840110115  0.323
1990 Klaunig JE, Ruch RJ, Weghorst CM. Comparative effects of phenobarbital, DDT, and lindane on mouse hepatocyte gap junctional intercellular communication Toxicology and Applied Pharmacology. 102: 553-563. PMID 1690460 DOI: 10.1016/0041-008X(90)90050-5  0.322
1990 Klaunig JE, Ruch RJ. Role of inhibition of intercellular communication in carcinogenesis. Laboratory Investigation. 62: 135-146. DOI: 10.1007/978-1-4612-0485-5_14  0.328
1989 Weghorst CM, Klaunig JE. Phenobarbital promotion in diethylnitrosamine-initiated infant b6c3f1 mice: Influence of gender Carcinogenesis. 10: 609-612. PMID 2924405 DOI: 10.1093/Carcin/10.3.609  0.325
1989 Lin ELC, Klaunig JE, Mattox JK, Weghorst CM, McFarland BH, Pereira MA. Comparison of the effects of acute and subacute treatment of phenobarbital in different strains of mice Cancer Letters. 48: 43-51. PMID 2819695 DOI: 10.1016/0304-3835(89)90201-2  0.329
1989 Ruch RJ, Crist KA, Klaunig JE. Effects of culture duration on hydrogen peroxide-induced hepatocyte toxicity Toxicology and Applied Pharmacology. 100: 451-464. PMID 2781569 DOI: 10.1016/0041-008X(89)90293-7  0.336
1989 Diwan BA, Lubet RA, Nims RW, Klaunig JE, Weghorst CM, Henneman JR, Ward JM, Rice JM. Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes. Carcinogenesis. 10: 1719-24. PMID 2766464 DOI: 10.1093/Carcin/10.9.1719  0.398
1989 Klaunig JE, Ruch RJ, Lin EL. Effects of trichloroethylene and its metabolites on rodent hepatocyte intercellular communication. Toxicology and Applied Pharmacology. 99: 454-65. PMID 2749732 DOI: 10.1016/0041-008X(89)90153-1  0.379
1989 Gross SA, Bandyopadhyay S, Klaunig JE, Somani P. Amiodarone and desethylamiodarone toxicity in isolated hepatocytes in culture. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 190: 163-9. PMID 2536944 DOI: 10.3181/00379727-190-42844  0.348
1989 Birkhahn RH, Awad S, Klaunig JE, Thomford NR. Interaction of ketosis and liver regeneration in the rat. The Journal of Surgical Research. 47: 427-32. PMID 2509817 DOI: 10.1016/0022-4804(89)90096-6  0.358
1989 Ruch RJ, Klaunig JE. Effects of tumor promoters, genotoxic carcinogens and hepatocytotoxins on mouse hepatocyte intercellular communication. Cell Biology and Toxicology. 2: 469-83. PMID 2477123 DOI: 10.1007/Bf00117849  0.338
1989 Ruch RJ, Cheng SJ, Klaunig JE. Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis. 10: 1003-8. PMID 2470525 DOI: 10.1093/Carcin/10.6.1003  0.348
1988 Ruch RJ, Klaunig JE. Inhibition of mouse hepatocyte intercellular communication by paraquat-generated oxygen free radicals. Toxicology and Applied Pharmacology. 94: 427-36. PMID 3400094 DOI: 10.1016/0041-008X(88)90283-9  0.352
1988 Klaunig JE, Weghorst CM, Pereira MA. Effect of phenobarbital on diethylnitrosamine and dimethylnitrosamine induced hepatocellular tumors in male B6C3F1 mice Cancer Letters. 42: 133-139. PMID 3180032 DOI: 10.1016/0304-3835(88)90250-9  0.328
1987 Klaunig JE, Barut BA. The efficacy of chemotherapeutic agents against murine bladder metastasis. The Journal of Urology. 138: 1471-3. PMID 3682079 DOI: 10.1016/S0022-5347(17)43677-9  0.318
1987 Klaunig JE, Weghorst CM, Pereira MA. Effect of the age of B6C3F1 mice on phenobarbital promotion of diethylnitrosamine-initiated liver tumors Toxicology and Applied Pharmacology. 90: 79-85. PMID 3629593 DOI: 10.1016/0041-008X(87)90308-5  0.326
1987 Klaunig JE, Ruch RJ. Strain and species effects on the inhibition of hepatocyte intercellular communication by liver tumor promoters. Cancer Letters. 36: 161-8. PMID 3621148 DOI: 10.1016/0304-3835(87)90087-5  0.356
1987 Hampton JA, Klaunig JE, Goldblatt PJ. Resident sinusoidal macrophages in the liver of the brown bullhead (Ictalurus nebulosus): an ultrastructural, functional and cytochemical study. The Anatomical Record. 219: 338-46. PMID 3448951 DOI: 10.1002/Ar.1092190403  0.35
1987 Goldblatt PJ, Hampton JA, DiDio LN, Skeel KA, Klaunig JE. Morphologic and histochemical analysis of the newt (Notophthalmus viridescens) liver. The Anatomical Record. 217: 328-38. PMID 3035962 DOI: 10.1002/Ar.1092170403  0.347
1987 Klaunig JE, Ruch RJ. Role of cyclic AMP in the inhibition of mouse hepatocyte intercellular communication by liver tumor promoters. Toxicology and Applied Pharmacology. 91: 159-70. PMID 2823418 DOI: 10.1016/0041-008X(87)90097-4  0.345
1987 Ruch RJ, Klaunig JE. Antioxidant prevention of tumor promoter induced inhibition of mouse hepatocyte intercellular communication. Cancer Letters. 33: 137-50. PMID 2431762 DOI: 10.1016/0304-3835(86)90018-2  0.364
1987 Nigrovic V, Klaunig JE, Smith SL, Schultz NE. Potentiation of Atracurium Toxicity in Isolated Rat Hepatocytes by Inhibition of its Hydrolytic Degradation Pathway Anesthesia & Analgesia. 66: 512???516. DOI: 10.1213/00000539-198706000-00005  0.347
1987 Weghorst CM, Pereira MA, Klaunig JE. Influence of the time of phenobarbital treatment on liver tumor development in initiated B6C3F1 mice Toxicology. 47: 211. DOI: 10.1016/0300-483X(87)90177-6  0.345
1987 Ruch RJ, Klaunig JE. Antioxidants, caffeine, and dibutyryl cAMP prevent the inhibition of mouse hepatocyte intercellular communication by liver tumor promoters Toxicology. 47: 208. DOI: 10.1016/0300-483X(87)90174-0  0.369
1987 Stoner GD, Shivapurkar NM, Schut HA, Klaunig JE, Mass MJ, Lehman TA. Metabolism of 4,4′-methylene-bis(2-chloroaniline) in explant cultures of human and dog bladder and dog liver cell cultures Toxicology. 47: 205. DOI: 10.1016/0300-483X(87)90170-3  0.318
1986 Dixit R, Schut HA, Klaunig JE, Stoner GD. Metabolism and DNA binding of 2,6-dinitrotoluene in Fischer-344 rats and A/J mice. Toxicology and Applied Pharmacology. 82: 53-61. PMID 3945944 DOI: 10.1016/0041-008X(86)90437-0  0.34
1986 Klaunig JE, Ruch RJ, Pereira MA. Carcinogenicity of chlorinated methane and ethane compounds administered in drinking water to mice Environmental Health Perspectives. 89-95. PMID 3816740 DOI: 10.1289/Ehp.866989  0.346
1986 Barut BA, Klaunig JE. Isolation and characterization of metastatic sublines from a murine transitional cell bladder carcinoma. Clinical & Experimental Metastasis. 4: 1-11. PMID 3698364 DOI: 10.1007/Bf00053468  0.309
1986 Nigrovic V, Klaunig JE, Smith SL, Schultz NE, Wajskol A. Comparative Toxicity of Atracurium and Metocurine in Isolated Rat Hepatocytes Anesthesia & Analgesia. 65: 1107???1111. DOI: 10.1213/00000539-198611000-00002  0.361
1986 Pereira MA, Klaunig JE, Freund SLH, Ruch RJ. Effect of phenobarbital on the development of liver tumors in juvenile and adult mice. Journal of the National Cancer Institute. 77: 449-452. DOI: 10.1093/Jnci/77.2.449  0.361
1985 Klaunig JE, Ruch RJ, Goldblatt PJ. Trout hepatocyte culture: isolation and primary culture. In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association. 21: 221-8. PMID 4008436 DOI: 10.1007/Bf02620933  0.31
1985 Chang LW, Pereira MA, Klaunig JE. Cytotoxicity of halogenated alkanes in primary cultures of rat hepatocytes from normal, partial hepatectomized, and preneoplastic/neoplastic liver. Toxicology and Applied Pharmacology. 80: 274-83. PMID 2862719 DOI: 10.1016/0041-008X(85)90084-5  0.4
1985 Ruch RJ, Klaunig JE, Pereira MA. Selective resistance to cytotoxic agents in hepatocytes isolated from partially hepatectomized and neoplastic mouse liver Cancer Letters. 26: 295-301. PMID 2581690 DOI: 10.1016/0304-3835(85)90053-9  0.362
1984 Stoner GD, Greisiger EA, Schut HA, Pereira MA, Loeb TR, Klaunig JE, Branstetter DG. A comparison of the lung adenoma response in strain A/J mice after intraperitoneal and oral administration of carcinogens. Toxicology and Applied Pharmacology. 72: 313-23. PMID 6695378 DOI: 10.1016/0041-008X(84)90316-8  0.337
1984 Klaunig JE, Ruch R, Krall C, Hamlett WC, Morse D, Goldblatt PJ. Morphology of liver tumors in brown bullhead catfish () from the black river in Ohio. Micron and Microscopica Acta. 15: 111-112. DOI: 10.1016/0739-6260(84)90015-7  0.321
1982 Stoner GD, Babcock MS, Cothern GA, Klaunig JE, Gunning WT, Knipe SM. In vitro transformation of rat esophageal epithelial cells with N-nitrosobenzylmethylamine. Carcinogenesis. 3: 629-34. PMID 7116556 DOI: 10.1093/Carcin/3.6.629  0.35
1982 Klaunig JE, Goldblatt PJ, Hinton DE, Lipsky MM, Knipe SM, Trump BF. Morphologic and functional studies of mouse hepatocytes in primary culture. The Anatomical Record. 204: 231-43. PMID 6130724 DOI: 10.1002/Ar.1092040308  0.328
1981 Klaunig JE, Goldblatt PJ, Hinton DE, Lipsky MM, Trump BF. Mouse liver cell culture. II. Primary culture. In Vitro. 17: 926-34. PMID 7309042 DOI: 10.1007/Bf02618289  0.349
1981 Klaunig JE, Goldblatt PJ, Hinton DE, Lipsky MM, Chacko J, Trump BF. Mouse liver cell culture. I. Hepatocyte isolation. In Vitro. 17: 913-25. PMID 6273298 DOI: 10.1007/Bf02618288  0.37
1981 Hinton D, Klaunig J, Jack R, Lipsky M, Trump B. In Vitro Evaluation of the Channel Catfish Ictalurus punctatus (Rafinesque) as a Test Species in Chemical Carcinogenesis Studies Astm Special Technical Publications. 226-238. DOI: 10.1520/Stp34159S  0.369
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