| Year |
Citation |
Score |
| 2023 |
Rosatelli E, Carotti A, Cerra B, De Franco F, Passeri D, Pellicciari R, Gioiello A. Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives. European Journal of Medicinal Chemistry. 261: 115851. PMID 37813065 DOI: 10.1016/j.ejmech.2023.115851 |
0.834 |
|
| 2022 |
Cerra B, Venturoni F, Souma M, Ceccarelli G, Lozza AM, Passeri D, De Franco F, Baxendale IR, Pellicciari R, Macchiarulo A, Gioiello A. Development of 3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites. European Journal of Medicinal Chemistry. 242: 114652. PMID 36049273 DOI: 10.1016/j.ejmech.2022.114652 |
0.802 |
|
| 2021 |
Mancino V, Ceccarelli G, Carotti A, Goracci L, Sardella R, Passeri D, Pellicciari R, Gioiello A. Synthesis and biological activity of cyclopropyl Δ7-dafachronic acids as DAF-12 receptor ligands. Organic & Biomolecular Chemistry. PMID 34056641 DOI: 10.1039/d1ob00912e |
0.828 |
|
| 2021 |
Perino A, Velázquez-Villegas LA, Bresciani N, Sun Y, Huang Q, Fénelon VS, Castellanos-Jankiewicz A, Zizzari P, Bruschetta G, Jin S, Baleisyte A, Gioiello A, Pellicciari R, Ivanisevic J, Schneider BL, et al. Central anorexigenic actions of bile acids are mediated by TGR5. Nature Metabolism. 3: 595-603. PMID 34031591 DOI: 10.1038/s42255-021-00398-4 |
0.793 |
|
| 2020 |
Dvorak Z, Klapholz M, Burris TP, Willing BP, Gioiello A, Pellicciari R, Galli F, March J, Sartor RB, Kim C, Levy M, Mani S, O'Keefe SJ. . Molecular Pharmacology. PMID 32764096 DOI: 10.1124/Molpharm.120.000035 |
0.797 |
|
| 2020 |
Sorrentino G, Perino A, Yildiz E, El Alam G, Sleiman MB, Gioiello A, Pellicciari R, Schoonjans K. Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration. Gastroenterology. PMID 32485177 DOI: 10.1053/J.Gastro.2020.05.067 |
0.788 |
|
| 2020 |
Tomassi S, Pfahler J, Mautone N, Rovere A, Esposito C, Passeri D, Pellicciari R, Novellino E, Pannek M, Steegborn C, Paiardini A, Mai A, Rotili D. From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. Acs Medicinal Chemistry Letters. 11: 862-868. PMID 32435397 DOI: 10.1021/Acsmedchemlett.9B00654 |
0.328 |
|
| 2020 |
Bartolini D, De Franco F, Torquato P, Marinelli R, Cerra B, Ronchetti R, Schön A, Fallarino F, De Luca A, Bellezza G, Ferri I, Sidoni A, Walton WG, Pellock SJ, Redinbo MR, ... ... Pellicciari R, et al. Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. Journal of Medicinal Chemistry. PMID 32160459 DOI: 10.1021/Acs.Jmedchem.0C00012.S001 |
0.827 |
|
| 2020 |
Bagnolini G, Milano D, Manerba M, Schipani F, Ortega JA, Gioia D, Falchi F, Balboni A, Farabegoli F, De Franco F, Robertson J, Pellicciari R, Pallavicini I, Peri S, Minucci S, et al. Synthetic lethality in pancreatic cancer: discovery of a new RAD51-BRCA2 small molecule disruptor that inhibits homologous recombination and synergizes with olaparib. Journal of Medicinal Chemistry. PMID 32037829 DOI: 10.1021/Acs.Jmedchem.9B01526 |
0.533 |
|
| 2019 |
Passeri D, Carotti A, Pittol JMR, Ciaccioli G, Pellicciari R, van Mil SWC, Gioiello A. Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool. Medchemcomm. 10: 1412-1419. PMID 31673308 DOI: 10.1039/C9Md00264B |
0.815 |
|
| 2019 |
Cerra B, Carotti A, Passeri D, Sardella R, Moroni G, Di Michele A, Macchiarulo A, Pellicciari R, Gioiello A. Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists. Acs Medicinal Chemistry Letters. 10: 677-681. PMID 30996817 DOI: 10.1021/Acsmedchemlett.8B00459 |
0.797 |
|
| 2019 |
Roberti M, Schipani F, Bagnolini G, Milano D, Giacomini E, Falchi F, Balboni A, Manerba M, Farabegoli F, De Franco F, Robertson J, Minucci S, Pallavicini I, Di Stefano G, Girotto S, ... Pellicciari R, et al. Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells. European Journal of Medicinal Chemistry. 165: 80-92. PMID 30660828 DOI: 10.1016/J.Ejmech.2019.01.008 |
0.515 |
|
| 2018 |
Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, ... ... Pellicciari R, et al. De novo NAD synthesis enhances mitochondrial function and improves health. Nature. PMID 30356218 DOI: 10.1038/S41586-018-0645-6 |
0.314 |
|
| 2018 |
Massafra V, Pellicciari R, Gioiello A, van Mil SWC. Progress and challenges of selective Farnesoid X receptor modulation. Pharmacology & Therapeutics. PMID 29933033 DOI: 10.1016/J.Pharmthera.2018.06.009 |
0.825 |
|
| 2018 |
Pellicciari R, Liscio P, Giacchè N, De Franco F, Carotti A, Robertson J, Cialabrini L, Katsyuba E, Raffaelli N, Auwerx J. α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) Inhibitors as Novel Modulators of de novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. Journal of Medicinal Chemistry. PMID 29345930 DOI: 10.1021/Acs.Jmedchem.7B01254 |
0.353 |
|
| 2018 |
Venturoni F, Cerra B, Marinozzi M, Camaioni E, Gioiello A, Pellicciari R. BF3·Et2O-Promoted Decomposition of Cyclic α-Diazo-β-Hydroxy Ketones: Novel Insights into Mechanistic Aspects Catalysts. 8: 600. DOI: 10.3390/Catal8120600 |
0.789 |
|
| 2017 |
Mostarda S, Passeri D, Carotti A, Cerra B, Colliva C, Benicchi T, Macchiarulo A, Pellicciari R, Gioiello A. Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification. European Journal of Medicinal Chemistry. 144: 349-358. PMID 29275233 DOI: 10.1016/J.Ejmech.2017.12.034 |
0.822 |
|
| 2017 |
Falchi F, Giacomini E, Masini T, Boutard N, Di Ianni L, Manerba M, Farabegoli F, Rossini L, Robertson J, Minucci S, Pallavicini I, Di Stefano G, Pellicciari R, Roberti M, Cavalli A. Synthetic lethality triggered by combining Olaparib with BRCA2-Rad51 disruptors. Acs Chemical Biology. PMID 28841282 DOI: 10.1021/Acschembio.7B00707 |
0.528 |
|
| 2017 |
Moniot S, Forgione M, Lucidi A, Hailu GS, Nebbioso A, Carafa V, Baratta F, Altucci L, Giacchè N, Passeri D, Pellicciari R, Mai A, Steegborn C, Rotili D. Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-Ray Crystal Structure and Anticancer Activity. Journal of Medicinal Chemistry. PMID 28240897 DOI: 10.1021/Acs.Jmedchem.6B01609 |
0.335 |
|
| 2016 |
Pellicciari R, Passeri D, De Franco F, Mostarda S, Filipponi P, Colliva C, Gadaleta R, Franco P, Carotti A, Macchiarulo A, Roda A, Moschetta A, Gioiello A. Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders. Journal of Medicinal Chemistry. PMID 27652492 DOI: 10.1021/Acs.Jmedchem.6B01126 |
0.813 |
|
| 2015 |
Passeri D, Camaioni E, Liscio P, Sabbatini P, Ferri M, Carotti A, Giacchè N, Pellicciari R, Gioiello A, Macchiarulo A. Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors. Chemmedchem. PMID 26424664 DOI: 10.1002/Cmdc.201500391 |
0.78 |
|
| 2015 |
Bijsmans IT, Guercini C, Ramos Pittol JM, Omta W, Milona A, Lelieveld D, Egan DA, Pellicciari R, Gioiello A, van Mil SW. The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression. Scientific Reports. 5: 14086. PMID 26369990 DOI: 10.1038/Srep14086 |
0.801 |
|
| 2015 |
Pellegrino M, Mancini F, Lucà R, Coletti A, Giacchè N, Manni I, Arisi I, Florenzano F, Teveroni E, Buttarelli M, Fici L, Brandi R, Bruno T, Fanciulli M, D'Onofrio M, ... ... Pellicciari R, et al. Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy. Cancer Research. 75: 4560-72. PMID 26359458 DOI: 10.1158/0008-5472.Can-15-0439 |
0.749 |
|
| 2015 |
Zhang W, Jha P, Wolfe B, Gioiello A, Pellicciari R, Wang J, Heubi J, Setchell KD. Tandem Mass Spectrometric Determination of Atypical 3β-Hydroxy-Δ5-Bile Acids in Patients with 3β-Hydroxy-Δ5-C27-Steroid Oxidoreductase Deficiency: Application to Diagnosis and Monitoring of Bile Acid Therapeutic Response. Clinical Chemistry. 61: 955-63. PMID 25931455 DOI: 10.1373/Clinchem.2015.238238 |
0.801 |
|
| 2014 |
Carotti A, Marinozzi M, Custodi C, Cerra B, Pellicciari R, Gioiello A, Macchiarulo A. Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and synthetic ligands. Current Topics in Medicinal Chemistry. 14: 2129-42. PMID 25388537 DOI: 10.2174/1568026614666141112094058 |
0.818 |
|
| 2014 |
Gioiello A, Cerra B, Mostarda S, Guercini C, Pellicciari R, Macchiarulo A. Bile acid derivatives as ligands of the farnesoid x receptor: molecular determinants for bile acid binding and receptor modulation. Current Topics in Medicinal Chemistry. 14: 2159-74. PMID 25388535 DOI: 10.2174/1568026614666141112100208 |
0.83 |
|
| 2014 |
Mostarda S, Filipponi P, Sardella R, Venturoni F, Natalini B, Pellicciari R, Gioiello A. Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs-Knorr reaction optimization. Organic & Biomolecular Chemistry. 12: 9592-600. PMID 25338931 DOI: 10.1039/C4Ob01911C |
0.793 |
|
| 2014 |
Liscio P, Carotti A, Asciutti S, Ferri M, Pires MM, Valloscuro S, Ziff J, Clark NR, Macchiarulo A, Aaronson SA, Pellicciari R, Camaioni E. Scaffold hopping approach on the route to selective tankyrase inhibitors. European Journal of Medicinal Chemistry. 87: 611-23. PMID 25299683 DOI: 10.1016/J.Ejmech.2014.10.007 |
0.759 |
|
| 2014 |
Marchand JR, Carotti A, Passeri D, Filipponi P, Liscio P, Camaioni E, Pellicciari R, Gioiello A, Macchiarulo A. Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. Biochimica Et Biophysica Acta. 1844: 1765-72. PMID 25062913 DOI: 10.1016/J.Bbapap.2014.07.012 |
0.78 |
|
| 2014 |
Gioiello A, Cerra B, Zhang W, Vallerini GP, Costantino G, De Franco F, Passeri D, Pellicciari R, Setchell KD. Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3β-hydroxy-Δ(5)-C27-steroid oxidoreductase deficiency. The Journal of Steroid Biochemistry and Molecular Biology. 144: 348-60. PMID 24954360 DOI: 10.1016/J.Jsbmb.2014.06.008 |
0.814 |
|
| 2014 |
Roda A, Pellicciari R, Gioiello A, Neri F, Camborata C, Passeri D, De Franco F, Spinozzi S, Colliva C, Adorini L, Montagnani M, Aldini R. Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat. The Journal of Pharmacology and Experimental Therapeutics. 350: 56-68. PMID 24784847 DOI: 10.1124/Jpet.114.214650 |
0.8 |
|
| 2014 |
Liscio P, Carotti A, Asciutti S, Karlberg T, Bellocchi D, Llacuna L, Macchiarulo A, Aaronson SA, Schüler H, Pellicciari R, Camaioni E. Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors. Journal of Medicinal Chemistry. 57: 2807-12. PMID 24527792 DOI: 10.1021/Jm401356T |
0.767 |
|
| 2014 |
Gioiello A, Venturoni F, Tamimi S, Custodi C, Pellicciari R, MacChiarulo A. Conformational properties of cholic acid, a lead compound at the crossroads of bile acid inspired drug discovery Medchemcomm. 5: 750-757. DOI: 10.1039/C4Md00024B |
0.812 |
|
| 2014 |
Filipponi P, Ostacolo C, Novellino E, Pellicciari R, Gioiello A. Continuous flow synthesis of thieno[2,3-c ]isoquinolin-5(4 H)-one scaffold: A valuable source of PARP-1 inhibitors Organic Process Research and Development. 18: 1345-1353. DOI: 10.1021/Op500074H |
0.783 |
|
| 2014 |
Asciutti S, Ferretti E, Valloscuro S, Pires MM, Llacuna L, Esposito D, Liscio P, Macchiarulo A, Camaioni E, Pellicciari R, Aaronson SA. Mo1915 Novel Wnt-Targeted Therapy Inhibitors for Hepatocellular Carcinoma Gastroenterology. 146: S-690. DOI: 10.1016/S0016-5085(14)62505-1 |
0.725 |
|
| 2013 |
Macchiarulo A, Gioiello A, Thomas C, Pols TW, Nuti R, Ferrari C, Giacchè N, De Franco F, Pruzanski M, Auwerx J, Schoonjans K, Pellicciari R. Probing the Binding Site of Bile Acids in TGR5. Acs Medicinal Chemistry Letters. 4: 1158-62. PMID 24900622 DOI: 10.1021/Ml400247K |
0.818 |
|
| 2013 |
Liscio P, Camaioni E, Carotti A, Pellicciari R, Macchiarulo A. From polypharmacology to target specificity: the case of PARP inhibitors. Current Topics in Medicinal Chemistry. 13: 2939-54. PMID 24171773 DOI: 10.2174/15680266113136660209 |
0.757 |
|
| 2013 |
Antolin AA, Carotti A, Nuti R, Hakkaya A, Camaioni E, Mestres J, Pellicciari R, Macchiarulo A. Exploring the effect of PARP-1 flexibility in docking studies. Journal of Molecular Graphics & Modelling. 45: 192-201. PMID 24056306 DOI: 10.1016/J.Jmgm.2013.08.006 |
0.767 |
|
| 2013 |
Sabbatini P, Filipponi P, Sardella R, Natalini B, Nuti R, Macchiarulo A, Pellicciari R, Gioiello A. Synthesis and quantitative structure-property relationships of side chain-modified hyodeoxycholic acid derivatives. Molecules (Basel, Switzerland). 18: 10497-513. PMID 23999724 DOI: 10.3390/Molecules180910497 |
0.832 |
|
| 2013 |
Marinozzi M, Carotti A, Sardella R, Buonerba F, Ianni F, Natalini B, Passeri D, Rizzo G, Pellicciari R. Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid X receptor (FXR) agonist: role of the chirality on the biological activity. Bioorganic & Medicinal Chemistry. 21: 3780-9. PMID 23684233 DOI: 10.1016/J.Bmc.2013.04.038 |
0.409 |
|
| 2013 |
Gioiello A, Rosatelli E, Teofrasti M, Filipponi P, Pellicciari R. Building a sulfonamide library by eco-friendly flow synthesis. Acs Combinatorial Science. 15: 235-9. PMID 23514257 DOI: 10.1021/Co400012M |
0.778 |
|
| 2012 |
Pellicciari R, Gioiello A, Sabbatini P, Venturoni F, Nuti R, Colliva C, Rizzo G, Adorini L, Pruzanski M, Roda A, Macchiarulo A. Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators. Acs Medicinal Chemistry Letters. 3: 273-7. PMID 24900463 DOI: 10.1021/Ml200256D |
0.822 |
|
| 2012 |
Gioiello A, Rosatelli E, Nuti R, Macchiarulo A, Pellicciari R. Patented TGR5 modulators: a review (2006 - present). Expert Opinion On Therapeutic Patents. 22: 1399-414. PMID 23039746 DOI: 10.1517/13543776.2012.733000 |
0.796 |
|
| 2012 |
Marinozzi M, Carotti A, Sansone E, Macchiarulo A, Rosatelli E, Sardella R, Natalini B, Rizzo G, Adorini L, Passeri D, De Franco F, Pruzanski M, Pellicciari R. Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists. Bioorganic & Medicinal Chemistry. 20: 3429-45. PMID 22564381 DOI: 10.1016/J.Bmc.2012.04.021 |
0.776 |
|
| 2012 |
Venturoni F, Gioiello A, Sardella R, Natalini B, Pellicciari R. Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts. Organic & Biomolecular Chemistry. 10: 4109-15. PMID 22517166 DOI: 10.1039/C2Ob25528F |
0.783 |
|
| 2012 |
Wahlberg E, Karlberg T, Kouznetsova E, Markova N, Macchiarulo A, Thorsell AG, Pol E, Frostell Å, Ekblad T, Öncü D, Kull B, Robertson GM, Pellicciari R, Schüler H, Weigelt J. Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors. Nature Biotechnology. 30: 283-8. PMID 22343925 DOI: 10.1038/Nbt.2121 |
0.766 |
|
| 2012 |
Gioiello A, Sardella R, Rosatelli E, Sadeghpour BM, Natalini B, Pellicciari R. Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone. Steroids. 77: 250-4. PMID 22155267 DOI: 10.1016/J.Steroids.2011.11.012 |
0.779 |
|
| 2011 |
Natalini B, Sardella R, Macchiarulo A, Marinozzi M, Camaioni E, Pellicciari R. Mechanistic Aspects and Applications of Chiral Ligand-Exchange Chromatography. Advances in Chromatography. 49: 71-134. PMID 26434236 DOI: 10.1201/B10721-4 |
0.75 |
|
| 2011 |
Pols TW, Nomura M, Harach T, Lo Sasso G, Oosterveer MH, Thomas C, Rizzo G, Gioiello A, Adorini L, Pellicciari R, Auwerx J, Schoonjans K. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metabolism. 14: 747-57. PMID 22152303 DOI: 10.1016/J.Cmet.2011.11.006 |
0.791 |
|
| 2011 |
Gioiello A, Venturoni F, Marinozzi M, Natalini B, Pellicciari R. Exploring the synthetic versatility of the Lewis acid induced decomposition reaction of α-diazo-β-hydroxy esters. The case of ethyl diazo(3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)acetate. The Journal of Organic Chemistry. 76: 7431-7. PMID 21800851 DOI: 10.1021/Jo201205U |
0.798 |
|
| 2011 |
Pocivavsek A, Wu HQ, Potter MC, Elmer GI, Pellicciari R, Schwarcz R. Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2357-67. PMID 21796108 DOI: 10.1038/Npp.2011.127 |
0.306 |
|
| 2011 |
Natalini B, Sardella R, Gioiello A, Rosatelli E, Ianni F, Camaioni E, Pellicciari R. Fast chromatographic determination of the bile salt critical micellar concentration. Analytical and Bioanalytical Chemistry. 401: 267-74. PMID 21573726 DOI: 10.1007/S00216-011-5082-4 |
0.811 |
|
| 2011 |
Gioiello A, Macchiarulo A, Carotti A, Filipponi P, Costantino G, Rizzo G, Adorini L, Pellicciari R. Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine. Bioorganic & Medicinal Chemistry. 19: 2650-8. PMID 21459580 DOI: 10.1016/J.Bmc.2011.03.004 |
0.813 |
|
| 2011 |
Passera E, Campanini B, Rossi F, Casazza V, Rizzi M, Pellicciari R, Mozzarelli A. Human kynurenine aminotransferase II--reactivity with substrates and inhibitors. The Febs Journal. 278: 1882-900. PMID 21439022 DOI: 10.1111/J.1742-4658.2011.08106.X |
0.402 |
|
| 2011 |
Macchiarulo A, Giacchè N, Mancini F, Puxeddu E, Moretti F, Pellicciari R. Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon? Expert Opinion On Therapeutic Patents. 21: 287-94. PMID 21342053 DOI: 10.1517/13543776.2011.546349 |
0.759 |
|
| 2011 |
Nielsen SD, Fulco M, Serpi M, Nielsen B, Hansen MB, Hansen KL, Thomsen C, Brodbeck R, Bräuner-Osborne H, Pellicciari R, Norrby PO, Greenwood JR, Clausen RP. A highly selective agonist for the metabotropic glutamate receptor mGluR2 Medchemcomm. 2: 1120-1124. DOI: 10.1039/C1Md00186H |
0.367 |
|
| 2011 |
Pellicciari R, Camaioni E, Gilbert AM, Macchiarulo A, Bikker JA, Shah F, Bard J, Costantino G, Gioiello A, Robertson GM, Sabbatini P, Venturoni F, Liscio P, Carotti A, Bellocchi D, et al. Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ Medchemcomm. 2: 559-565. DOI: 10.1039/C1Md00021G |
0.794 |
|
| 2011 |
Macchiarulo A, Giacchè N, Carotti A, Moretti F, Pellicciari R. Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4) Medchemcomm. 2: 455-465. DOI: 10.1039/C0Md00238K |
0.745 |
|
| 2011 |
Kelly OB, Pellicciari R, Roda A, Hofmann AF, Murray FE, Keely SJ. Dehydroxylation-Resistant Derivatives of Ursodeoxycholic Acid: A New Approach to Treating Secretory Diarrheal Diseases? Gastroenterology. 140: S-658. DOI: 10.1016/S0016-5085(11)62728-5 |
0.307 |
|
| 2011 |
Gioiello A, Sabbatini P, Rosatelli E, MacChiarulo A, Pellicciari R. Divergent and stereoselective synthesis of dafachronic acids Tetrahedron. 67: 1924-1929. DOI: 10.1016/J.Tet.2011.01.022 |
0.808 |
|
| 2010 |
Natalini B, Giacchè N, Sardella R, Ianni F, Macchiarulo A, Pellicciari R. Computational studies for the elucidation of the enantiomer elution order of amino acids in chiral ligand-exchange chromatography. Journal of Chromatography. A. 1217: 7523-7. PMID 20977972 DOI: 10.1016/J.Chroma.2010.10.001 |
0.771 |
|
| 2010 |
Cellanetti M, Gunda V, Wang L, Macchiarulo A, Pellicciari R. Insights into the binding mode and mechanism of action of some atypical retinoids as ligands of the small heterodimer partner (SHP). Journal of Computer-Aided Molecular Design. 24: 943-56. PMID 20882396 DOI: 10.1007/S10822-010-9386-9 |
0.787 |
|
| 2010 |
Dezi C, Carotti A, Magnani M, Baroni M, Padova A, Cruciani G, Macchiarulo A, Pellicciari R. Molecular interaction fields and 3D-QSAR studies of p53-MDM2 inhibitors suggest additional features of ligand-target interaction. Journal of Chemical Information and Modeling. 50: 1451-65. PMID 20726601 DOI: 10.1021/Ci100113P |
0.768 |
|
| 2010 |
Zhou T, Zhang Y, Macchiarulo A, Yang Z, Cellanetti M, Coto E, Xu P, Pellicciari R, Wang L. Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes. The Journal of Biological Chemistry. 285: 24871-81. PMID 20516075 DOI: 10.1074/Jbc.M110.133280 |
0.754 |
|
| 2010 |
Natalini B, Sardella R, Giacchè N, Palmiotto S, Camaioni E, Marinozzi M, Macchiarulo A, Pellicciari R. Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids. Analytical and Bioanalytical Chemistry. 397: 1997-2011. PMID 20496034 DOI: 10.1007/S00216-010-3669-9 |
0.765 |
|
| 2010 |
Mancini F, Di Conza G, Monti O, Macchiarulo A, Pellicciari R, Pontecorvi A, Moretti F. Puzzling over MDM4-p53 network. The International Journal of Biochemistry & Cell Biology. 42: 1080-3. PMID 20417304 DOI: 10.1016/J.Biocel.2010.04.010 |
0.742 |
|
| 2010 |
Wu HQ, Pereira EF, Bruno JP, Pellicciari R, Albuquerque EX, Schwarcz R. The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex. Journal of Molecular Neuroscience : Mn. 40: 204-10. PMID 19690987 DOI: 10.1007/S12031-009-9235-2 |
0.303 |
|
| 2010 |
Rizzo G, Passeri D, De Franco F, Ciaccioli G, Sadeghpour B, Pellicciari R, Pruzanski M, Adorini L. 1114 FUNCTIONAL CHARACTERIZATION OF THE SEMI-SYNTHETIC BILE ACID DERIVATIVE INT-767, A DUAL FXR AND TGR5 AGONIST Journal of Hepatology. 52: S430-S431. DOI: 10.1016/S0168-8278(10)61115-4 |
0.404 |
|
| 2010 |
Roberti M, Natalini B, Andrisano V, Seraglia R, Gioiello A, Pellicciari R. Thermal and catalytic reactions of ethyl diazopyruvate with [60]fullerene Tetrahedron. 66: 7329-7332. DOI: 10.1016/J.Tet.2010.06.067 |
0.764 |
|
| 2010 |
PELLICCIARI R, NATALINI B, LUNEIA R, MARINOZZI M, ROBERTI M, ROSATO GC, SADEGHPOUR BM, SNYDER JP, MONAHAN JB, MORONI F. ChemInform Abstract: Enantioselective Synthesis of Naturally Occurring trans-4-Hydroxy-S- pipecolic Acid-4-sulfate, a New Potent and Selective NMDA Receptor Agonist. Cheminform. 24: no-no. DOI: 10.1002/chin.199328257 |
0.306 |
|
| 2009 |
Pellicciari R, Gioiello A, Macchiarulo A, Thomas C, Rosatelli E, Natalini B, Sardella R, Pruzanski M, Roda A, Pastorini E, Schoonjans K, Auwerx J. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. Journal of Medicinal Chemistry. 52: 7958-61. PMID 20014870 DOI: 10.1021/Jm901390P |
0.813 |
|
| 2009 |
Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, Schoonjans K. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metabolism. 10: 167-77. PMID 19723493 DOI: 10.1016/J.Cmet.2009.08.001 |
0.793 |
|
| 2009 |
Bellocchi D, Macchiarulo A, Carotti A, Pellicciari R. Quantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of L-kynurenine to kynurenic acid: the round dance of kynurenine aminotransferase II. Biochimica Et Biophysica Acta. 1794: 1802-12. PMID 19715778 DOI: 10.1016/J.Bbapap.2009.08.016 |
0.756 |
|
| 2009 |
Natalini B, Sardella R, Gioiello A, Carbone G, Dawgul M, Pellicciari R. Side-chain modified bile acids: chromatographic separation of 23-methyl epimers. Journal of Separation Science. 32: 2022-33. PMID 19548211 DOI: 10.1002/Jssc.200900080 |
0.805 |
|
| 2009 |
Carotti A, Macchiarulo A, Giacchè N, Pellicciari R. Targeting the conformational transitions of MDM2 and MDMX: insights into key residues affecting p53 recognition. Proteins. 77: 524-35. PMID 19507240 DOI: 10.1002/Prot.22464 |
0.746 |
|
| 2009 |
Macchiarulo A, Pellicciari R. MDM2/MDMX inhibitor peptide: WO2008106507. Expert Opinion On Therapeutic Patents. 19: 721-6. PMID 19441944 DOI: 10.1517/13543770902755137 |
0.745 |
|
| 2009 |
Formentini L, Macchiarulo A, Cipriani G, Camaioni E, Rapizzi E, Pellicciari R, Moroni F, Chiarugi A. Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure. The Journal of Biological Chemistry. 284: 17668-76. PMID 19411252 DOI: 10.1074/Jbc.M109.002931 |
0.725 |
|
| 2009 |
Gioiello A, Venturoni F, Natalini B, Pellicciari R. BF(3).Et(2)O-induced decomposition of ethyl 2-diazo-3-hydroxy-3,3-diarylpropanoates in acetonitrile: a novel approach to 2,3-diaryl beta-enamino ester derivatives. The Journal of Organic Chemistry. 74: 3520-3. PMID 19341244 DOI: 10.1021/Jo802775Q |
0.776 |
|
| 2009 |
Natalini B, Sardella R, Carbone G, Macchiarulo A, Pellicciari R. The effect of the copper(II) salt anion in the Chiral Ligand-Exchange Chromatography of amino acids. Analytica Chimica Acta. 638: 225-33. PMID 19327465 DOI: 10.1016/J.Aca.2009.02.031 |
0.767 |
|
| 2009 |
Macchiarulo A, Nuti R, Eren G, Pellicciari R. Charting the chemical space of target sites: insights into the binding modes of amine and amidine groups. Journal of Chemical Information and Modeling. 49: 900-12. PMID 19292498 DOI: 10.1021/Ci800414V |
0.755 |
|
| 2009 |
Amori L, Guidetti P, Pellicciari R, Kajii Y, Schwarcz R. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. Journal of Neurochemistry. 109: 316-25. PMID 19226371 DOI: 10.1111/J.1471-4159.2009.05893.X |
0.316 |
|
| 2009 |
Amori L, Wu HQ, Marinozzi M, Pellicciari R, Guidetti P, Schwarcz R. Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience. 159: 196-203. PMID 19138730 DOI: 10.1016/J.Neuroscience.2008.11.055 |
0.306 |
|
| 2009 |
Natalini B, Sardella R, Camaioni E, Macchiarulo A, Gioiello A, Carbone G, Pellicciari R. Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids. Journal of Pharmaceutical and Biomedical Analysis. 50: 613-21. PMID 19081222 DOI: 10.1016/J.Jpba.2008.10.035 |
0.8 |
|
| 2009 |
Filosa R, Carmela Fulco M, Marinozzi M, Giacchè N, Macchiarulo A, Peduto A, Massa A, de Caprariis P, Thomsen C, Christoffersen CT, Pellicciari R. Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands. Bioorganic & Medicinal Chemistry. 17: 242-50. PMID 19042134 DOI: 10.1016/J.Bmc.2008.11.015 |
0.792 |
|
| 2009 |
Macchiarulo A, Camaioni E, Nuti R, Pellicciari R. Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease. Amino Acids. 37: 219-29. PMID 18612775 DOI: 10.1007/S00726-008-0137-3 |
0.754 |
|
| 2009 |
Gioiello A, Khamidullina A, Fulco MC, Venturoni F, Zlotsky S, Pellicciari R. New one-pot synthesis of pyrazole-5-carboxylates by 1,3-dipole cycloadditions of ethyl diazoacetate with α-methylene carbonyl compounds Tetrahedron Letters. 50: 5978-5980. DOI: 10.1016/J.Tetlet.2009.07.152 |
0.79 |
|
| 2009 |
Fulco MC, Marinozzi M, Çaliskan Ergün B, Sardella R, Natalini B, Pellicciari R. Synthesis and chromatographic resolution of conformationally constrained analogues of homotaurine Tetrahedron. 65: 8756-8762. DOI: 10.1016/J.Tet.2009.08.018 |
0.33 |
|
| 2008 |
Macchiarulo A, Giacchè N, Carotti A, Baroni M, Cruciani G, Pellicciari R. Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition. Journal of Chemical Information and Modeling. 48: 1999-2009. PMID 18826207 DOI: 10.1021/Ci800146M |
0.752 |
|
| 2008 |
Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, et al. Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity. Journal of Medicinal Chemistry. 51: 5650-62. PMID 18759424 DOI: 10.1021/Jm800456K |
0.774 |
|
| 2008 |
Macchiarulo A, Gioiello A, Thomas C, Massarotti A, Nuti R, Rosatelli E, Sabbatini P, Schoonjans K, Auwerx J, Pellicciari R. Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. Journal of Chemical Information and Modeling. 48: 1792-801. PMID 18698841 DOI: 10.1021/Ci800196H |
0.818 |
|
| 2008 |
Thomas C, Pellicciari R, Pruzanski M, Auwerx J, Schoonjans K. Targeting bile-acid signalling for metabolic diseases. Nature Reviews. Drug Discovery. 7: 678-93. PMID 18670431 DOI: 10.1038/Nrd2619 |
0.341 |
|
| 2008 |
Natalini B, Macchiarulo A, Sardella R, Massarotti A, Pellicciari R. Descriptive structure-separation relationship studies in chiral ligand-exchange chromatography. Journal of Separation Science. 31: 2395-403. PMID 18646268 DOI: 10.1002/Jssc.200800102 |
0.75 |
|
| 2008 |
Natalini B, Sardella R, Macchiarulo A, Pellicciari R. Cysteine-based chiral selectors for the ligand-exchange separation of amino acids. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 875: 108-17. PMID 18579457 DOI: 10.1016/J.Jchromb.2008.06.007 |
0.777 |
|
| 2008 |
Pellicciari R, Venturoni F, Bellocchi D, Carotti A, Marinozzi M, Macchiarulo A, Amori L, Schwarcz R. Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA. Chemmedchem. 3: 1199-202. PMID 18537204 DOI: 10.1002/Cmdc.200800109 |
0.728 |
|
| 2008 |
Pellicciari R, Camaioni E, Costantino G, Formentini L, Sabbatini P, Venturoni F, Eren G, Bellocchi D, Chiarugi A, Moroni F. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. Chemmedchem. 3: 914-23. PMID 18409175 DOI: 10.1002/Cmdc.200800010 |
0.317 |
|
| 2008 |
Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, Auwerx J. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. Journal of Medicinal Chemistry. 51: 1831-41. PMID 18307294 DOI: 10.1021/Jm7015864 |
0.831 |
|
| 2008 |
Natalini B, Sardella R, Macchiarulo A, Pellicciari R. S-trityl-(R)-cysteine, a powerful chiral selector for the analytical and preparative ligand-exchange chromatography of amino acids. Journal of Separation Science. 31: 696-704. PMID 18266296 DOI: 10.1002/Jssc.200700511 |
0.765 |
|
| 2007 |
Pellicciari R, Marinozzi M, Macchiarulo A, Fulco MC, Gafarova J, Serpi M, Giorgi G, Nielsen S, Thomsen C. Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. Journal of Medicinal Chemistry. 50: 4630-41. PMID 17725337 DOI: 10.1021/Jm070322E |
0.788 |
|
| 2007 |
Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, Auwerx J. Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5. Journal of Medicinal Chemistry. 50: 4265-8. PMID 17685603 DOI: 10.1021/Jm070633P |
0.821 |
|
| 2007 |
Macchiarulo A, Nuti R, Bellocchi D, Camaioni E, Pellicciari R. Molecular docking and spatial coarse graining simulations as tools to investigate substrate recognition, enhancer binding and conformational transitions in indoleamine-2,3-dioxygenase (IDO). Biochimica Et Biophysica Acta. 1774: 1058-68. PMID 17644054 DOI: 10.1016/J.Bbapap.2007.06.007 |
0.754 |
|
| 2007 |
Natalini B, Sardella R, Camaioni E, Gioiello A, Pellicciari R. Correlation between CMC and chromatographic index: simple and effective evaluation of the hydrophobic/hydrophilic balance of bile acids. Analytical and Bioanalytical Chemistry. 388: 1681-8. PMID 17572887 DOI: 10.1007/S00216-007-1360-6 |
0.796 |
|
| 2007 |
Macchiarulo A, Pellicciari R. Exploring the other side of biologically relevant chemical space: insights into carboxylic, sulfonic and phosphonic acid bioisosteric relationships. Journal of Molecular Graphics & Modelling. 26: 728-39. PMID 17544772 DOI: 10.1016/J.Jmgm.2007.04.010 |
0.773 |
|
| 2007 |
Marinozzi M, Serpi M, Amori L, Gavilan Diaz M, Costantino G, Meyer U, Flor PJ, Gasparini F, Heckendorn R, Kuhn R, Giorgi G, Hermit MB, Thomsen C, Pellicciari R. Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. Bioorganic & Medicinal Chemistry. 15: 3161-70. PMID 17350267 DOI: 10.1016/J.Bmc.2007.02.040 |
0.337 |
|
| 2007 |
Natalini B, Sardella R, Macchiarulo A, Natalini S, Pellicciari R. (S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidinemethanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography. Journal of Separation Science. 30: 21-7. PMID 17313137 DOI: 10.1002/Jssc.200600242 |
0.754 |
|
| 2007 |
Ceresoli-Borroni G, Guidetti P, Amori L, Pellicciari R, Schwarcz R. Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. Journal of Neuroscience Research. 85: 845-54. PMID 17279543 DOI: 10.1002/Jnr.21183 |
0.3 |
|
| 2007 |
Pellicciari R, Amori L, Kuznetsova N, Zlotsky S, Gioiello A. Indium triflate catalyzed reaction of diisopropyl diazomethylphosphonate with imines as a new approach to cis- and trans-aziridine-2-phosphonates Tetrahedron Letters. 48: 4911-4914. DOI: 10.1016/J.Tetlet.2007.05.042 |
0.781 |
|
| 2006 |
Ferrari C, Macchiarulo A, Costantino G, Pellicciari R. Pharmacophore model for bile acids recognition by the FPR receptor. Journal of Computer-Aided Molecular Design. 20: 295-303. PMID 16972170 DOI: 10.1007/S10822-006-9055-1 |
0.814 |
|
| 2006 |
Bellocchi D, Costantino G, Pellicciari R, Re N, Marrone A, Coletti C. Poly(ADP-ribose)-polymerase-catalyzed hydrolysis of NAD+: QM/MM simulation of the enzyme reaction. Chemmedchem. 1: 533-9. PMID 16892389 DOI: 10.1002/Cmdc.200500061 |
0.305 |
|
| 2006 |
Pellicciari R, Filosa R, Fulco MC, Marinozzi M, Macchiarulo A, Novak C, Natalini B, Hermit MB, Nielsen S, Sager TN, Stensbøl TB, Thomsen C. Synthesis and preliminary biological evaluation of 2'-substituted 2-(3'-carboxybicyclo[1.1.1]pentyl)glycine derivatives as group I selective metabotropic glutamate receptor ligands. Chemmedchem. 1: 358-65. PMID 16892370 DOI: 10.1002/Cmdc.200500071 |
0.789 |
|
| 2006 |
Pellicciari R, Gioiello A, Costantino G, Sadeghpour BM, Rizzo G, Meyer U, Parks DJ, Entrena-Guadix A, Fiorucci S. Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. Journal of Medicinal Chemistry. 49: 4208-15. PMID 16821780 DOI: 10.1021/Jm060294K |
0.815 |
|
| 2006 |
Rizzo G, Disante M, Mencarelli A, Renga B, Gioiello A, Pellicciari R, Fiorucci S. The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo. Molecular Pharmacology. 70: 1164-73. PMID 16778009 DOI: 10.1124/Mol.106.023820 |
0.79 |
|
| 2006 |
Natalini B, Sardella R, Macchiarulo A, Pellicciari R. Dynamic ligand-exchange chiral stationary phase from S-benzyl-(R)-cysteine. Chirality. 18: 509-18. PMID 16634129 DOI: 10.1002/Chir.20280 |
0.754 |
|
| 2006 |
Clerici C, Castellani D, Asciutti S, Pellicciari R, Setchell KD, O'Connell NC, Sadeghpour B, Camaioni E, Fiorucci S, Renga B, Nardi E, Sabatino G, Clementi M, Giuliano V, Baldoni M, et al. 3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats. Toxicology and Applied Pharmacology. 214: 199-208. PMID 16487557 DOI: 10.1016/J.Taap.2005.12.017 |
0.329 |
|
| 2006 |
Filosa R, Marinozzi M, Costantino G, Hermit MB, Thomsen C, Pellicciari R. Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. Bioorganic & Medicinal Chemistry. 14: 3811-7. PMID 16460952 DOI: 10.1016/J.Bmc.2006.01.027 |
0.389 |
|
| 2006 |
Macchiarulo A, Rizzo G, Costantino G, Fiorucci S, Pellicciari R. Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). Journal of Molecular Graphics & Modelling. 24: 362-72. PMID 16288980 DOI: 10.1016/J.Jmgm.2005.09.016 |
0.782 |
|
| 2006 |
Sapko MT, Guidetti P, Yu P, Tagle DA, Pellicciari R, Schwarcz R. Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease. Experimental Neurology. 197: 31-40. PMID 16099455 DOI: 10.1016/J.Expneurol.2005.07.004 |
0.314 |
|
| 2006 |
Pellicciari R, Gioiello A, Costantino G. Potential therapeutic applications of farnesoid X receptor (FXR) modulators Expert Opinion On Therapeutic Patents. 16: 333-341. DOI: 10.1517/13543776.16.3.333 |
0.818 |
|
| 2006 |
Natalini B, Sardella R, Camaioni E, Natalini S, Pellicciari R. Dominant factors affecting the chromatographic behaviour of bile acids Chromatographia. 64: 343-349. DOI: 10.1365/S10337-006-0108-3 |
0.329 |
|
| 2005 |
Meyer U, Costantino G, Macchiarulo A, Pellicciari R. Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. Journal of Medicinal Chemistry. 48: 6948-55. PMID 16250653 DOI: 10.1021/Jm0505056 |
0.785 |
|
| 2005 |
Rizzo G, Renga B, Mencarelli A, Pellicciari R, Fiorucci S. Role of FXR in regulating bile acid homeostasis and relevance for human diseases. Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 5: 289-303. PMID 16178789 DOI: 10.2174/1568008054863781 |
0.445 |
|
| 2005 |
Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Morelli A, Pruzanski M, Pellicciari R. Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis. The Journal of Pharmacology and Experimental Therapeutics. 315: 58-68. PMID 15980055 DOI: 10.1124/Jpet.105.085597 |
0.347 |
|
| 2005 |
Rizzo G, Renga B, Antonelli E, Passeri D, Pellicciari R, Fiorucci S. The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. Molecular Pharmacology. 68: 551-8. PMID 15911693 DOI: 10.1124/Mol.105.012104 |
0.361 |
|
| 2005 |
Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pruzanski M, Morelli A, Pellicciari R. A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. The Journal of Pharmacology and Experimental Therapeutics. 314: 584-95. PMID 15860571 DOI: 10.1124/Jpet.105.084905 |
0.305 |
|
| 2005 |
Costantino G, Entrena-Guadix A, Macchiarulo A, Gioiello A, Pellicciari R. Molecular dynamics simulation of the ligand binding domain of farnesoid X receptor. Insights into helix-12 stability and coactivator peptide stabilization in response to agonist binding. Journal of Medicinal Chemistry. 48: 3251-9. PMID 15857131 DOI: 10.1021/Jm049182O |
0.784 |
|
| 2005 |
Bellocchi D, Macchiarulo A, Costantino G, Pellicciari R. Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecule. Bioorganic & Medicinal Chemistry. 13: 1151-7. PMID 15670923 DOI: 10.1016/J.Bmc.2004.11.024 |
0.75 |
|
| 2005 |
Fiorucci S, Clerici C, Antonelli E, Orlandi S, Goodwin B, Sadeghpour BM, Sabatino G, Russo G, Castellani D, Willson TM, Pruzanski M, Pellicciari R, Morelli A. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. The Journal of Pharmacology and Experimental Therapeutics. 313: 604-12. PMID 15644430 DOI: 10.1124/Jpet.104.079665 |
0.39 |
|
| 2005 |
Natalini B, Sardella R, Pellicciari R. O-Benzyl-(S)-Serine, a New Chiral Selector for Ligand-Exchange Chromatography of Amino Acids Current Analytical Chemistry. 1: 85-92. DOI: 10.2174/1573411052948479 |
0.356 |
|
| 2005 |
Jirgensons A, Marinozzi M, Pellicciari R. Conformationally constrained amino acids: Enantiodivergent synthesis of all four stereoisomers of 2-(tetrahydrofuran-2-yl)glycine Tetrahedron. 61: 373-377. DOI: 10.1016/J.Tet.2004.10.091 |
0.365 |
|
| 2004 |
Fiorucci S, Antonelli E, Rizzo G, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pellicciari R, Morelli A. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Gastroenterology. 127: 1497-512. PMID 15521018 DOI: 10.1053/J.Gastro.2004.08.001 |
0.365 |
|
| 2004 |
Pleban K, Macchiarulo A, Costantino G, Pellicciari R, Chiba P, Ecker GF. Homology model of the multidrug transporter LmrA from Lactococcus lactis. Bioorganic & Medicinal Chemistry Letters. 14: 5823-6. PMID 15501048 DOI: 10.1016/J.Bmcl.2004.09.040 |
0.732 |
|
| 2004 |
Macchiarulo A, Costantino G, Meniconi M, Pleban K, Ecker G, Bellocchi D, Pellicciari R. Insights into phenylalanine derivatives recognition of VLA-4 integrin: from a pharmacophoric study to 3D-QSAR and molecular docking analyses. Journal of Chemical Information and Computer Sciences. 44: 1829-39. PMID 15446843 DOI: 10.1021/Ci049914L |
0.786 |
|
| 2004 |
Pellicciari R, Costantino G, Camaioni E, Sadeghpour BM, Entrena A, Willson TM, Fiorucci S, Clerici C, Gioiello A. Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. Journal of Medicinal Chemistry. 47: 4559-69. PMID 15317466 DOI: 10.1021/Jm049904B |
0.828 |
|
| 2004 |
Natalini B, Marinozzi M, Sardella R, Macchiarulo A, Pellicciari R. Evaluation of the enantiomeric selectivity in the chiral ligand-exchange chromatography of amino acids by a computational model. Journal of Chromatography. A. 1033: 363-7. PMID 15088759 DOI: 10.1016/J.Chroma.2004.01.054 |
0.76 |
|
| 2004 |
Natalini B, Marinozzi M, Bade K, Sardella R, Thomsen C, Pellicciari R. Preparative resolution of 1-aminoindan-1,5-dicarboxylic acid (AIDA) by chiral ligand-exchange chromatography. Chirality. 16: 314-7. PMID 15069662 DOI: 10.1002/Chir.20027 |
0.411 |
|
| 2004 |
Macchiarulo A, De Luca L, Costantino G, Barreca ML, Gitto R, Pellicciari R, Chimirri A. QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor. Journal of Medicinal Chemistry. 47: 1860-3. PMID 15027880 DOI: 10.1021/Jm0310838 |
0.774 |
|
| 2004 |
Pellicciari R, Camaioni E, Costantino G. 3. Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia. Progress in Medicinal Chemistry. 42: 125-69. PMID 15003720 DOI: 10.1016/S0079-6468(04)42003-7 |
0.307 |
|
| 2004 |
Costantino G, Marinozzi M, Camaioni E, Natalini B, Sarichelou I, Micheli F, Cavanni P, Faedo S, Noe C, Moroni F, Pellicciari R. Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist. Farmaco (Societã Chimica Italiana : 1989). 59: 93-9. PMID 14871500 DOI: 10.1016/J.Farmac.2003.11.008 |
0.366 |
|
| 2004 |
Marinozzi M, Fulco MC, Rizzo R, Pellicciari R. Synthesis of novel unsymmetrically bridgehead-substituted phenylseleno-bicyclo[1.1.1]pentanes Synlett. 1027-1028. DOI: 10.1055/S-2004-822882 |
0.303 |
|
| 2003 |
Pellicciari R, Amori L, Costantino G, Giordani A, Macchiarulo A, Mattoli L, Pevarello P, Speciale C, Varasi M. Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. Advances in Experimental Medicine and Biology. 527: 621-8. PMID 15206781 DOI: 10.1007/978-1-4615-0135-0_71 |
0.765 |
|
| 2003 |
Traversa U, Bombi G, Camaioni E, Macchiarulo A, Costantino G, Palmieri C, Caciagli F, Pellicciari R. Rat brain guanosine binding site. Biological studies and pseudo-receptor construction. Bioorganic & Medicinal Chemistry. 11: 5417-25. PMID 14642586 DOI: 10.1016/J.Bmc.2003.09.043 |
0.771 |
|
| 2003 |
Pellicciari R, Camaioni E, Costantino G, Marinozzi M, Macchiarulo A, Moroni F, Natalini B. Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors. Farmaco (Societã Chimica Italiana : 1989). 58: 851-8. PMID 13679179 DOI: 10.1016/S0014-827X(03)00143-5 |
0.765 |
|
| 2003 |
Belenikin MS, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular dynamic simulation of the ligand-receptor complexes of the aminoterminal domain of the metabotropic glutamate receptor mGluR1. Doklady. Biochemistry and Biophysics. 389: 98-102. PMID 12856414 DOI: 10.1023/A:1023684122445 |
0.336 |
|
| 2003 |
Belenikin MS, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular modeling of the ligand-binding domains of the NR3A and NR3B subunits of the NMDA receptor. Doklady. Biochemistry and Biophysics. 389: 83-9. PMID 12856411 DOI: 10.1023/A:1023627904698 |
0.33 |
|
| 2003 |
Costantino G, Macchiarulo A, Entrena-Guadix A, Camaioni E, Pellicciari R. Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR). Bioorganic & Medicinal Chemistry Letters. 13: 1865-8. PMID 12749886 DOI: 10.1016/S0960-894X(03)00281-6 |
0.789 |
|
| 2003 |
Mi LZ, Devarakonda S, Harp JM, Han Q, Pellicciari R, Willson TM, Khorasanizadeh S, Rastinejad F. Structural basis for bile acid binding and activation of the nuclear receptor FXR. Molecular Cell. 11: 1093-100. PMID 12718893 DOI: 10.1016/S1097-2765(03)00112-6 |
0.442 |
|
| 2003 |
Chiarugi A, Meli E, Calvani M, Picca R, Baronti R, Camaioni E, Costantino G, Marinozzi M, Pellegrini-Giampietro DE, Pellicciari R, Moroni F. Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia. The Journal of Pharmacology and Experimental Therapeutics. 305: 943-9. PMID 12606624 DOI: 10.1124/Jpet.103.048934 |
0.316 |
|
| 2003 |
De Luca L, Macchiarulo A, Costantino G, Barreca ML, Gitto R, Chimirri A, Pellicciari R. Binding modes of noncompetitive AMPA antagonists: a computational approach. Farmaco (Societã Chimica Italiana : 1989). 58: 107-13. PMID 12581776 DOI: 10.1016/S0014-827X(02)00027-7 |
0.772 |
|
| 2003 |
Macchiarulo A, Costantino G, Sbaglia R, Aiello S, Meniconi M, Pellicciari R. The role of electrostatic interaction in the molecular recognition of selective agonists to metabotropic glutamate receptors. Proteins. 50: 609-19. PMID 12577267 DOI: 10.1002/Prot.10301 |
0.769 |
|
| 2003 |
Fiorucci S, Clerici C, Castellani D, Sabatino G, Antonelli E, Goodwin B, Willson TM, Setchell KD, Morelli A, Pellicciari R. The FXR-agonist, 6-ethyl-chenodeoxycholic acid (6-ECDCA), protects against estrogen-induced cholestasis in rats Gastroenterology. 124: A698. DOI: 10.1016/S0016-5085(03)83528-X |
0.333 |
|
| 2002 |
Costantino G, Macchiarulo A, Belenikin M, Pellicciari R. Molecular dynamics simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding. Journal of Computer-Aided Molecular Design. 16: 779-84. PMID 12825789 DOI: 10.1023/A:1023876410800 |
0.761 |
|
| 2002 |
Belenikin MS, Baskin II, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Comparative analysis of the ligand-binding sites of the metabotropic glutamate receptors mGluR1-mGluR8. Doklady. Biochemistry and Biophysics. 386: 251-6. PMID 12469502 DOI: 10.1023/A:1020755427019 |
0.433 |
|
| 2002 |
Belenikin MS, Baskin II, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular modeling of the closed forms of the kainate-binding domains of kainate receptors and qualitative analysis of the structure-activity relationships for some agonists. Doklady. Biochemistry and Biophysics. 386: 239-44. PMID 12469499 DOI: 10.1023/A:1020799209272 |
0.36 |
|
| 2002 |
Schwarcz R, Pellicciari R. Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities. The Journal of Pharmacology and Experimental Therapeutics. 303: 1-10. PMID 12235226 DOI: 10.1124/Jpet.102.034439 |
0.376 |
|
| 2002 |
Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, Morelli A, Parks DJ, Willson TM. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. Journal of Medicinal Chemistry. 45: 3569-72. PMID 12166927 DOI: 10.1021/Jm025529G |
0.397 |
|
| 2002 |
Pellicciari R, Marinozzi M, Camaioni E, del Carmen Nùnez M, Costantino G, Gasparini F, Giorgi G, Macchiarulo A, Subramanian N. Spiro[2.2]pentane as a dissymmetric scaffold for conformationally constrained analogues of glutamic acid: focus on racemic 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids. The Journal of Organic Chemistry. 67: 5497-507. PMID 12153247 DOI: 10.1021/Jo020138V |
0.784 |
|
| 2002 |
Moroni F, Attucci S, Cozzi A, Meli E, Picca R, Scheideler MA, Pellicciari R, Noe C, Sarichelou I, Pellegrini-Giampietro DE. The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology. 42: 741-51. PMID 12015200 DOI: 10.1016/S0028-3908(02)00033-3 |
0.333 |
|
| 2002 |
Matveeva ED, Podrugina TA, Zefirova ON, Alekseev AS, Bachurin SO, Pellicciari R, Zefirov NS. Syntheses of compounds active toward glutamate receptors: I. New preparative synthesis of aminoindandicarboxylic acid (AIDA) Russian Journal of Organic Chemistry. 38: 1764-1768. DOI: 10.1023/A:1022515613414 |
0.311 |
|
| 2002 |
Costantino G, Rovito R, Macchiarulo A, Pellicciari R. Structure of metal-carbenoid intermediates derived from the dirhodium(II)tetracarboxylate mediated decomposition of α-diazocarbonyl compounds: A DFT study Journal of Molecular Structure: Theochem. 581: 111-115. DOI: 10.1016/S0166-1280(01)00747-3 |
0.739 |
|
| 2001 |
Costantino G, Macchiarulo A, Pellicciari R. Metabotropic glutamate receptors: targets for therapy of cerebral ischaemia. Expert Opinion On Therapeutic Targets. 5: 669-683. PMID 12540277 DOI: 10.1517/14728222.5.6.669 |
0.768 |
|
| 2001 |
Pellicciari R, Costantino G, Marinozzi M, Macchiarulo A, Amori L, Josef Flor P, Gasparini F, Kuhn R, Urwyler S. Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors. Bioorganic & Medicinal Chemistry Letters. 11: 3179-82. PMID 11720869 DOI: 10.1016/S0960-894X(01)00656-4 |
0.765 |
|
| 2001 |
Costantino G, Macchiarulo A, Camaioni E, Pellicciari R. Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis. Journal of Medicinal Chemistry. 44: 3786-94. PMID 11689065 DOI: 10.1021/Jm010116L |
0.775 |
|
| 2001 |
Terán Moldes MC, Costantino G, Marinozzi M, Pellicciari R. Synthesis and preliminary biological evaluation at the glycineB site of (+)- and (-)-3-oxetanylglycine, novel non-proteinogenic amino acids. Farmaco (Societã Chimica Italiana : 1989). 56: 609-13. PMID 11601647 DOI: 10.1016/S0014-827X(01)01101-6 |
0.402 |
|
| 2001 |
Costantino G, Macchiarulo A, Entrena Guadix A, Pellicciari R. QSAR and molecular modeling studies of baclofen analogues as GABA(B) agonists. Insights into the role of the aromatic moiety in GABA(B) binding and activation. Journal of Medicinal Chemistry. 44: 1827-32. PMID 11356116 DOI: 10.1021/Jm0100133 |
0.758 |
|
| 2001 |
Costantino G, Macchiarulo A, Pellicciari R. Homology model of the closed, functionally active, form of the amino terminal domain of mGlur1. Bioorganic & Medicinal Chemistry. 9: 847-52. PMID 11354667 DOI: 10.1016/S0968-0896(00)00311-4 |
0.768 |
|
| 2001 |
Pellicciari R, Costantino G, Marinozzi M, Macchiarulo A, Camaioni E, Natalini B. Metabotropic glutamate receptors: structure and new subtype-selective ligands. Farmaco (Societã Chimica Italiana : 1989). 56: 91-4. PMID 11347974 DOI: 10.1016/S0014-827X(01)01006-0 |
0.784 |
|
| 2001 |
Costantino G, Maltoni K, Marinozzi M, Camaioni E, Prezeau L, Pin JP, Pellicciari R. Synthesis and biological evaluation of 2-(3'-(1H-tetrazol-5-yl) bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 receptor antagonist. Bioorganic & Medicinal Chemistry. 9: 221-7. PMID 11249114 DOI: 10.1016/S0968-0896(00)00270-4 |
0.372 |
|
| 2000 |
Costantino G, Wolf C, Natalini B, Pellicciari R. Evaluation of hydrophobic/hydrophilic balance of bile acids by comparative molecular field analysis (CoMFA). Steroids. 65: 483-9. PMID 10978726 DOI: 10.1016/S0039-128X(00)00108-2 |
0.351 |
|
| 2000 |
Amori L, Costantino G, Marinozzi M, Pellicciari R, Gasparini F, Flor PJ, Kuhn R, Vranesic I. Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. Bioorganic & Medicinal Chemistry Letters. 10: 1447-50. PMID 10888329 DOI: 10.1016/S0960-894X(00)00247-X |
0.453 |
|
| 2000 |
Pellicciari R, Costantino G, Macchiarulo A. Metabotropic glutamate receptors: a structural view point. Pharmaceutica Acta Helvetiae. 74: 231-7. PMID 10812963 DOI: 10.1016/S0031-6865(99)00055-2 |
0.777 |
|
| 2000 |
Parmentier ML, Galvez T, Acher F, Peyre B, Pellicciari R, Grau Y, Bockaert J, Pin JP. Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution. Neuropharmacology. 39: 1119-31. PMID 10760355 DOI: 10.1016/S0028-3908(99)00204-X |
0.384 |
|
| 2000 |
Pellicciari R, Natalini B, Amori L, Marinozzi M, Seraglia R. Synthesis of methano[60]fullerenephosphonic- and methano[60]fullerene-diphosphonic acids Synlett. 1816-1818. DOI: 10.1055/S-2000-8680 |
0.367 |
|
| 2000 |
Pellicciari R, Costantino G, Macchiarulo A. Metabotropic glutamate receptors: a structural view point Pharmacochemistry Library. 31: 231-237. DOI: 10.1016/S0165-7208(00)80023-9 |
0.743 |
|
| 2000 |
Marinozzi M, Pellicciari R. Novel enantioselective synthesis of (2S,2′R,3′R)-2-(2′,3′-dicarboxycyclopropyl)glycine (DCG-IV) Tetrahedron Letters. 41: 9125-9128. DOI: 10.1016/S0040-4039(00)01629-4 |
0.318 |
|
| 2000 |
Clerici C, Pellicciari R, Setchell K, O'Connel N, Gentili G, Morelli O, Clementi M, Russo G, Marinozzi G, Gallo P, Verta M, Morelli A. Amino acid derivatives of UDCA as novel prodrugs for colon-specific drug delivery Gastroenterology. 118: A517. DOI: 10.1016/S0016-5085(00)84195-5 |
0.341 |
|
| 1999 |
Costantino G, Macchiarulo A, Pellicciari R. Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity. Journal of Medicinal Chemistry. 42: 5390-401. PMID 10639281 DOI: 10.1021/Jm990353C |
0.783 |
|
| 1999 |
Pellegrini-Giampietro DE, Cozzi A, Peruginelli F, Leonardi P, Meli E, Pellicciari R, Moroni F. 1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia. The European Journal of Neuroscience. 11: 3637-47. PMID 10564371 DOI: 10.1046/J.1460-9568.1999.00786.X |
0.369 |
|
| 1999 |
Di Giacomo B, Coletta D, Natalini B, Ni MH, Pellicciari R. A new synthesis of carboxyterfenadine (fexofenadine) and its bioisosteric tetrazole analogs. Farmaco (Societã Chimica Italiana : 1989). 54: 600-10. PMID 10555262 DOI: 10.1016/S0014-827X(99)00070-1 |
0.307 |
|
| 1999 |
Straface E, Natalini B, Monti D, Franceschi C, Schettini G, Bisaglia M, Fumelli C, Pincelli C, Pellicciari R, Malorni W. C3-fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability. Febs Letters. 454: 335-40. PMID 10431834 DOI: 10.1016/S0014-5793(99)00812-1 |
0.317 |
|
| 1999 |
Mannaioni G, Attucci S, Missanelli A, Pellicciari R, Corradetti R, Moroni F. Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity. Neuropharmacology. 38: 917-26. PMID 10428410 DOI: 10.1016/S0028-3908(99)00021-0 |
0.349 |
|
| 1999 |
Costantino G, Macchiarulo A, Pellicciari R. Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity. Journal of Medicinal Chemistry. 42: 2816-27. PMID 10425091 DOI: 10.1021/Jm990182B |
0.758 |
|
| 1999 |
Pellicciari R, Costantino G. Metabotropic G-protein-coupled glutamate receptors as therapeutic targets. Current Opinion in Chemical Biology. 3: 433-40. PMID 10419848 DOI: 10.1016/S1367-5931(99)80064-7 |
0.335 |
|
| 1999 |
Pellicciari R, Marinozzi M, Costantino G, Natalini B, Moroni F, Pellegrini-Giampietro D. (2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties. Journal of Medicinal Chemistry. 42: 2716-20. PMID 10411492 DOI: 10.1021/Jm990128V |
0.362 |
|
| 1998 |
Pellicciari R, Costantino G, Giovagnoni E, Mattoli L, Brabet I, Pin JP. Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist. Bioorganic & Medicinal Chemistry Letters. 8: 1569-74. PMID 9873392 DOI: 10.1016/S0960-894X(98)00265-0 |
0.363 |
|
| 1998 |
Pellicciari R, Costantino G, Marinozzi M, Natalini B. Modulation of glutamate receptor pathways in the search for new neuroprotective agents. Farmaco (Societã Chimica Italiana : 1989). 53: 255-61. PMID 9658582 DOI: 10.1016/S0014-827X(98)00018-4 |
0.365 |
|
| 1998 |
Moroni F, Cozzi A, Lombardi G, Sourtcheva S, Leonardi P, Carfì M, Pellicciari R. Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex. European Journal of Pharmacology. 347: 189-95. PMID 9653880 DOI: 10.1016/S0014-2999(98)00124-1 |
0.355 |
|
| 1997 |
Cozzi A, Attucci S, Peruginelli F, Marinozzi M, Luneia R, Pellicciari R, Moroni F. Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist. The European Journal of Neuroscience. 9: 1350-5. PMID 9240392 DOI: 10.1111/J.1460-9568.1997.Tb01489.X |
0.358 |
|
| 1996 |
Aldini R, Roda A, Montagnani M, Cerrè C, Pellicciari R, Roda E. Relationship between structure and intestinal absorption of bile acids with a steroid or side-chain modification. Steroids. 61: 590-7. PMID 8910972 DOI: 10.1016/S0039-128X(96)00119-5 |
0.329 |
|
| 1996 |
Costantino G, Mattoli L, Moroni F, Natalini B, Pellicciari R. Kynurenine-3-hydroxylase and its selective inhibitors. Molecular modeling studies. Advances in Experimental Medicine and Biology. 398: 493-7. PMID 8906310 DOI: 10.1007/978-1-4613-0381-7_76 |
0.402 |
|
| 1996 |
Costantino G, Pellicciari R. Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists. Journal of Medicinal Chemistry. 39: 3998-4006. PMID 8831765 DOI: 10.1021/Jm9601718 |
0.367 |
|
| 1996 |
Pellicciari R, Raimondo M, Marinozzi M, Natalini B, Costantino G, Thomsen C. (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist. Journal of Medicinal Chemistry. 39: 2874-6. PMID 8709120 DOI: 10.1021/Jm960254O |
0.336 |
|
| 1996 |
Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C. Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist. Journal of Medicinal Chemistry. 39: 2259-69. PMID 8667369 DOI: 10.1021/Jm960059+ |
0.375 |
|
| 1996 |
Pellicciari R, Natalini B, Sadeghpour BM, Marinozzi M, Snyder JP, Williamson BL, Kuethe JT, Padwa A. The Reaction of α-Diazo-β-hydroxy Esters with Boron Trifluoride Etherate: Generation and Rearrangement of Destabilized Vinyl Cations. A Detailed Experimental and Theoretical Study Journal of the American Chemical Society. 118: 1-12. DOI: 10.1021/Ja950971S |
0.315 |
|
| 1996 |
Marinozzi M, Natalini B, Costantino G, Tijskens P, Thomsen C, Pellicciari R. Asymmetric synthesis of enantiomerically pure (2S,1′S,2′S,3′R)-phenylcarboxycyclopropylglycine (PCCG-4): a potent and selective ligand at group II metabotropic glutamate receptors Bioorganic & Medicinal Chemistry Letters. 6: 2243-2246. DOI: 10.1016/0960-894X(96)00407-6 |
0.348 |
|
| 1996 |
Pellicciari R, Costantino G, Marinozzi M, Natalini B. mGluRs novel ligands and molecular modeling studies Neuropharmacology. 35: A23. DOI: 10.1016/0028-3908(96)84737-X |
0.316 |
|
| 1996 |
Moroni F, Lombardi G, Pellegrini-Giampietro D, Leonardi P, Attucci S, Mannaioni G, Peruginelli F, Albani S, Thomsen C, Pellicciari R. Pharmacological studies on new agonists and antagonists of mGluRs Neuropharmacology. 35: A21. DOI: 10.1016/0028-3908(96)84729-0 |
0.324 |
|
| 1996 |
Costantino G, Pellicciari R. Homology modeling of mGluR1 ATD reveals different modes of binding of mGluR1 agonists and antagonists Neuropharmacology. 35: A10. DOI: 10.1016/0028-3908(96)84684-3 |
0.304 |
|
| 1996 |
Bruno V, Storto M, Pellicciari R, Nicoletti F. The neuroprotective activity of group-II mGlu receptor agonist is sensitive to protein synthesis inhibitors and involves the interaction between neurons and astrocytes Neuropharmacology. 35: A6. DOI: 10.1016/0028-3908(96)84670-3 |
0.334 |
|
| 1995 |
Roda A, Pellicciari R, Polimeni C, Cerrè C, Forti GC, Sadeghpour B, Sapigni E, Gioacchini AM, Natalini B. Metabolism, pharmacokinetics, and activity of a new 6-fluoro analogue of ursodeoxycholic acid in rats and hamsters. Gastroenterology. 108: 1204-14. PMID 7698590 DOI: 10.1016/0016-5085(95)90221-X |
0.389 |
|
| 1995 |
Chiarugi A, Carpenedo R, Molina MT, Mattoli L, Pellicciari R, Moroni F. Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase. Journal of Neurochemistry. 65: 1176-83. PMID 7643095 DOI: 10.1046/J.1471-4159.1995.65031176.X |
0.415 |
|
| 1995 |
Pellicciari R, Luneia R, Costantino G, Marinozzi M, Natalini B, Jakobsen P, Kanstrup A, Lombardi G, Moroni F, Thomsen C. 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. Journal of Medicinal Chemistry. 38: 3717-9. PMID 7562903 DOI: 10.1021/Jm00019A002 |
0.388 |
|
| 1995 |
Moroni F, Galli A, Mannaioni G, Carla V, Cozzi A, Mori F, Marinozzi M, Pellicciari R. NMDA receptor heterogeneity in mammalian tissues: focus on two agonists, (2S,3R,4S) cyclopropylglutamate and the sulfate ester of 4-hydroxy-(S)-pipecolic acid. Naunyn-Schmiedeberg's Archives of Pharmacology. 351: 371-6. PMID 7543185 DOI: 10.1007/Bf00169077 |
0.319 |
|
| 1995 |
Pellicciari R, Arenare L, Caprariis PD, Natalini B, Marinozzi M, Galli A. Synthesis of all four diastereoisomers of 4-(carboxymethyl)proline, a conformationally constrained analogue of 2-aminoadipic acid Journal of the Chemical Society-Perkin Transactions 1. 1251-1257. DOI: 10.1039/P19950001251 |
0.416 |
|
| 1995 |
Lombardi G, Thomsen C, Leonardi P, Albani S, Pellicciari R, Moroni F. Pharmacological studies on agonists and antagonists of metabotropic glutamate receptors Pharmacological Research. 31: 297. DOI: 10.1016/1043-6618(95)87446-1 |
0.335 |
|
| 1995 |
Eddine Saïah M, Pellicciari R. Rhodium-catalysed redox isomerization of hydroxy alkynes to trans keto and hydroxy vinyl esters. A short and stereoselective synthesis of dipeptide isosters Tetrahedron Letters. 36: 4497-4500. DOI: 10.1016/0040-4039(95)00768-8 |
0.336 |
|
| 1994 |
Mannaioni G, Alesiani M, Carlà V, Natalini B, Marinozzi M, Pellicciari R, Moroni F. Sulfate esters of hydroxy amino acids as stereospecific glutamate receptor agonists. European Journal of Pharmacology. 251: 201-7. PMID 8149976 DOI: 10.1016/0014-2999(94)90401-4 |
0.407 |
|
| 1994 |
Pellicciari R, Natalini B, Costantino G, Mahmoud MR, Mattoli L, Sadeghpour BM, Moroni F, Chiarugi A, Carpenedo R. Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase. Journal of Medicinal Chemistry. 37: 647-55. PMID 8126705 DOI: 10.1021/Jm00031A015 |
0.318 |
|
| 1994 |
Clerici C, Gentili G, Boschetti E, Santucci C, Aburbeh AG, Natalini B, Pellicciari R, Morelli A. Amino acid derivatives of 5-ASA as novel prodrugs for intestinal drug delivery. Digestive Diseases and Sciences. 39: 2601-6. PMID 7995185 DOI: 10.1007/Bf02087696 |
0.309 |
|
| 1994 |
Lombardi G, Pellegrini-Giampietro DE, Leonard P, Cherici G, Pellicciari R, Moroni F. The depolarization-induced outflow of D-[3H]aspartate from rat brain slices is modulated by metabotropic glutamate receptors. Neurochemistry International. 24: 525-32. PMID 7981633 DOI: 10.1016/0197-0186(94)90003-5 |
0.357 |
|
| 1994 |
Carpenedo R, Chiarugi A, Russi P, Lombardi G, Carlà V, Pellicciari R, Mattoli L, Moroni F. Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities. Neuroscience. 61: 237-43. PMID 7969905 DOI: 10.1016/0306-4522(94)90227-5 |
0.339 |
|
| 1994 |
Arenare L, De Caprariis P, Marinozzi M, Natalini B, Pellicciari R. Synthesis of 2-azabicyclo[3.1.0]hexane tricarboxylate and its transformation into a new proline-γ-acetic acid equivalent Tetrahedron Letters. 35: 1425-1426. DOI: 10.1016/S0040-4039(00)76236-8 |
0.317 |
|
| 1993 |
Pellicciari R, Natalini B, Costantino G, Garzon A, Luneia R, Mahmoud MR, Marinozzi M, Roberti M, Rosato GC, Shiba SA. Heterocyclic modulators of the NMDA receptor. Farmaco (Societã Chimica Italiana : 1989). 48: 151-7. PMID 8494596 |
0.546 |
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| 1993 |
Lombardi G, Alesiani M, Leonardi P, Cherici G, Pellicciari R, Moroni F. Pharmacological characterization of the metabotropic glutamate receptor inhibiting D-[3H]-aspartate output in rat striatum. British Journal of Pharmacology. 110: 1407-12. PMID 8306080 DOI: 10.1111/J.1476-5381.1993.Tb13977.X |
0.327 |
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| 1993 |
Pellicciari R, Garzon-Aburbeh A, Natalini B, Marinozzi M, Clerici C, Gentili G, Morelli A. Brush-border-enzyme-mediated intestine-specific drug delivery. Amino acid prodrugs of 5-aminosalicylic acid. Journal of Medicinal Chemistry. 36: 4201-7. PMID 8277502 DOI: 10.1021/Jm00078A009 |
0.356 |
|
| 1993 |
Costantino G, Natalini B, Pellicciari R, Moroni F, Lombardi G. Definition of a pharmacophore for the metabotropic glutamate receptors negatively linked to adenylyl cyclase. Bioorganic & Medicinal Chemistry. 1: 259-65. PMID 7915955 DOI: 10.1016/S0968-0896(00)82130-6 |
0.349 |
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| 1992 |
Clerici C, Dozzini G, Distrutti E, Gentili G, Sadeghpour BM, Natalini B, Pellicciari R, Rizzoli R, Roda A, Pelli MA. Effect of intraduodenal administration of 23-methyl-UDCA diastereoisomers on bile flow in hamsters. Digestive Diseases and Sciences. 37: 791-8. PMID 1563325 DOI: 10.1007/Bf01296441 |
0.328 |
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| 1992 |
Russi P, Alesiani M, Lombardi G, Davolio P, Pellicciari R, Moroni F. Nicotinylalanine increases the formation of kynurenic acid in the brain and antagonizes convulsions. Journal of Neurochemistry. 59: 2076-80. PMID 1431895 DOI: 10.1111/J.1471-4159.1992.Tb10097.X |
0.373 |
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| 1992 |
Pellicciari R, Gallo-Mezo MA, Natalini B, Amer AM. Stereospecific synthesis of the enantiomers of nicotinylalanine, a neuroprotecting agent Tetrahedron Letters. 33: 3003-3004. DOI: 10.1016/S0040-4039(00)79583-9 |
0.309 |
|
| 1992 |
Snyder JP, Rao SN, Koehler KF, Pellicciari R. Drug Modeling at Cell Membrane Receptors: The Concept of Pseudoreceptors Pharmacochemistry Library. 18: 367-403. DOI: 10.1016/B978-0-444-88931-7.50026-8 |
0.402 |
|
| 1992 |
Galli A, Mori F, Natalini B, Pellicciari R. Structure-activity relationship of kynurenate analogues for interaction with the glycine site on the n-methyl-o-aspartate (NMDA) receptor Pharmacological Research. 26: 243. DOI: 10.1016/1043-6618(92)91195-M |
0.303 |
|
| 1991 |
Moroni F, Russi P, Gallo-Mezo MA, Moneti G, Pellicciari R. Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanine. Journal of Neurochemistry. 57: 1630-5. PMID 1833509 DOI: 10.1111/J.1471-4159.1991.Tb06361.X |
0.382 |
|
| 1991 |
Moroni F, Alesiani M, Galli A, Mori F, Pecorari R, Carlà V, Cherici G, Pellicciari R. Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor. European Journal of Pharmacology. 199: 227-32. PMID 1720099 DOI: 10.1016/0014-2999(91)90461-X |
0.395 |
|
| 1991 |
Dappen MS, Pellicciari R, Natalini B, Monahan JB, Chiorri C, Cordi AA. Synthesis and biological evaluation of cyclopropyl analogues of 2-amino-5-phosphonopentanoic acid. Journal of Medicinal Chemistry. 34: 161-8. PMID 1671413 DOI: 10.1021/Jm00105A024 |
0.411 |
|
| 1990 |
Monahan JB, Hood WF, Compton RP, Cordi AA, Snyder JP, Pellicciari R, Natalini B. Characterization of D-3,4-cyclopropylglutamates as N-methyl-D-aspartate receptor agonists. Neuroscience Letters. 112: 328-32. PMID 2163042 DOI: 10.1016/0304-3940(90)90225-X |
0.334 |
|
| 1990 |
Moroni F, Alesiani M, Galli A, Carla V, Pellicciari R. Structure-activity studies on thiol derivatives of kynurenic acid Pharmacological Research. 22: 350. DOI: 10.1016/S1043-6618(09)80368-X |
0.378 |
|
| 1990 |
Pellicciari R, Natalini B, Marinozzi M, Monahan JB, Snyder JP. D-3,4-‘cyclopropylglutamate’ isomers as nmda receptor ligands: Synthesis and enantioselective activity. Tetrahedron Letters. 31: 139-142. DOI: 10.1016/S0040-4039(00)94355-7 |
0.349 |
|
| 1989 |
Pellicciari R, Natalini B, Roda A, Machado MIL, Marinozzi M. Preparation and physicochemical properties of natural (23R)-3α,7α,23- and (23R)-3α,12α,23-trihydroxylated bile acids and their (23S)-epimers Journal of the Chemical Society-Perkin Transactions 1. 1289-1296. DOI: 10.1039/P19890001289 |
0.315 |
|
| 1988 |
Pellicciari R, Natalini B, Cecchetti S, Porter B, Roda A, Grigolo B, Balducci R. Bile acids with a cyclopropyl-containing side chain. 3. Separation, identification, and properties of all four stereoisomers of 3 alpha,7 beta-dihydroxy-22,23-methylene-5 beta-cholan-24-oic acid. Journal of Medicinal Chemistry. 31: 730-6. PMID 3351848 DOI: 10.1021/Jm00399A007 |
0.322 |
|
| 1988 |
Roda A, Grigolo B, Roda E, Simoni P, Pellicciari R, Natalini B, Fini A, Labate AM. Quantitative relationship between bile acid structure and biliary lipid secretion in rats. Journal of Pharmaceutical Sciences. 77: 596-605. PMID 3171946 DOI: 10.1002/Jps.2600770710 |
0.341 |
|
| 1988 |
Pellicciari R, Natalini B, Marinozzi M. L-α-Aminoadipic Acid from L-Glutamic Acid Synthetic Communications. 18: 1707-1714. DOI: 10.1080/00397918808081333 |
0.317 |
|
| 1985 |
Pellicciari R, Cecchetti S, Natalini B, Roda A, Grigolo B, Fini A. Bile acids with cyclopropane-containing side chain. 2. Synthesis and properties of 3 alpha,7 beta-dihydroxy-22,23-methylene-5 beta-cholan-24-oic acid (2-sulfoethyl)amide. Journal of Medicinal Chemistry. 28: 239-42. PMID 3968688 DOI: 10.1021/Jm00380A015 |
0.309 |
|
| 1985 |
Pellicciari R, Natalini B, Cecchetti S, Fringuelli R. Reduction of α-diazo-β-hydroxy esters to β-hydroxy esters: application in one of two convergent syntheses of a (22S)-22-hydroxy bile acid from fish bile and its (22R)-epimer Journal of the Chemical Society-Perkin Transactions 1. 16: 493-497. DOI: 10.1039/P19850000493 |
0.345 |
|
| 1984 |
Pellicciari R, Cecchetti S, Natalini B, Roda A, Grigolo B, Fini A. Bile acids with a cyclopropyl-containing side chain. 1. Preparation and properties of 3 alpha, 7 beta-dihydroxy-22,23-methylene-5 beta-cholan-24-oic acid. Journal of Medicinal Chemistry. 27: 746-9. PMID 6737415 DOI: 10.1021/Jm00372A007 |
0.316 |
|
| 1984 |
Pellicciari R, Natalini B, Cecchetti S, Santucci S. Photolysis of α-diazo carbonyl compounds in the presence of imidazole. A new method for the preparation of nor olefins and its application to bile acid side chain degradation Tetrahedron Letters. 25: 3103-3106. DOI: 10.1016/0040-4039(84)80019-2 |
0.379 |
|
| 1982 |
Ceccherelli P, Curini M, Pellicciari R, Wenkert E. A partial homo-favorskii rearrangement in the diterpene series Journal of Organic Chemistry. 47: 3172-3174. DOI: 10.1021/Jo00137A031 |
0.493 |
|
| 1974 |
CECCHERELLI P, PELLICCIARI R, GOLOB NF, SMITH RAJ, WENKERT E. ChemInform Abstract: BICYCLO(3,2,0)HEPTANOLS Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/Chin.197407204 |
0.44 |
|
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