E. Helene Sage - Publications

Affiliations: 
2006 Hope Heart Matrix Biology Program Benaroya Research Institute 
Area:
Molecular Biology

144 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Murphy-Ullrich JE, Sage EH. Revisiting the matricellular concept. Matrix Biology : Journal of the International Society For Matrix Biology. 37: 1-14. PMID 25064829 DOI: 10.1016/J.Matbio.2014.07.005  0.375
2013 Oh DJ, Kang MH, Ooi YH, Choi KR, Sage EH, Rhee DJ. Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix. Investigative Ophthalmology & Visual Science. 54: 3309-19. PMID 23599341 DOI: 10.1167/Iovs.12-11362  0.366
2013 Cheng L, Sage EH, Yan Q. SPARC fusion protein induces cellular adhesive signaling. Plos One. 8: e53202. PMID 23349702 DOI: 10.1371/Journal.Pone.0053202  0.476
2012 Rangel R, Guzman-Rojas L, le Roux LG, Staquicini FI, Hosoya H, Barbu EM, Ozawa MG, Nie J, Jr KD, Langley RR, Sage EH, Koivunen E, Gelovani JG, Lobb RR, Sidman RL, et al. Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells. Nature Communications. 3: 788. PMID 22510693 DOI: 10.1038/Ncomms1773  0.307
2012 Millecamps M, Tajerian M, Naso L, Sage EH, Stone LS. Lumbar intervertebral disc degeneration associated with axial and radiating low back pain in ageing SPARC-null mice. Pain. 153: 1167-79. PMID 22414871 DOI: 10.1016/J.Pain.2012.01.027  0.321
2011 Kucukdereli H, Allen NJ, Lee AT, Feng A, Ozlu MI, Conatser LM, Chakraborty C, Workman G, Weaver M, Sage EH, Barres BA, Eroglu C. Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. Proceedings of the National Academy of Sciences of the United States of America. 108: E440-9. PMID 21788491 DOI: 10.1073/Pnas.1104977108  0.319
2011 Weaver M, Workman G, Schultz CR, Lemke N, Rempel SA, Sage EH. Proteolysis of the matricellular protein hevin by matrix metalloproteinase-3 produces a SPARC-like fragment (SLF) associated with neovasculature in a murine glioma model. Journal of Cellular Biochemistry. 112: 3093-102. PMID 21688302 DOI: 10.1002/Jcb.23235  0.36
2011 Workman G, Sage EH. Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1. Journal of Cellular Biochemistry. 112: 1003-8. PMID 21308731 DOI: 10.1002/Jcb.23015  0.382
2011 Nie J, Bradshaw AD, Delany AM, Sage EH. Inactivation of SPARC enhances high-fat diet-induced obesity in mice. Connective Tissue Research. 52: 99-108. PMID 20615096 DOI: 10.3109/03008207.2010.483747  0.645
2010 Bota PC, Collie AM, Puolakkainen P, Vernon RB, Sage EH, Ratner BD, Stayton PS. Biomaterial topography alters healing in vivo and monocyte/macrophage activation in vitro. Journal of Biomedical Materials Research. Part A. 95: 649-57. PMID 20725970 DOI: 10.1002/Jbm.A.32893  0.335
2010 Seet LF, Su R, Barathi VA, Lee WS, Poh R, Heng YM, Manser E, Vithana EN, Aung T, Weaver M, Sage EH, Wong TT. SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery. Plos One. 5: e9415. PMID 20195533 DOI: 10.1371/Journal.Pone.0009415  0.372
2010 Weaver MS, Workman G, Cardo-Vila M, Arap W, Pasqualini R, Sage EH. Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4. The Journal of Biological Chemistry. 285: 5868-77. PMID 20018883 DOI: 10.1074/Jbc.M109.070318  0.337
2010 Arnold SA, Rivera LB, Miller AF, Carbon JG, Dineen SP, Xie Y, Castrillon DH, Sage EH, Puolakkainen P, Bradshaw AD, Brekken RA. Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma. Disease Models & Mechanisms. 3: 57-72. PMID 20007485 DOI: 10.1242/Dmm.003228  0.624
2009 Nie J, Sage EH. SPARC functions as an inhibitor of adipogenesis. Journal of Cell Communication and Signaling. 3: 247-54. PMID 19798596 DOI: 10.1007/S12079-009-0064-4  0.454
2009 Schellings MW, van Almen GC, Sage EH, Heymans S. Thrombospondins in the heart: potential functions in cardiac remodeling. Journal of Cell Communication and Signaling. 3: 201-13. PMID 19798592 DOI: 10.1007/S12079-009-0070-6  0.323
2009 Mandelin J, Lin EC, Hu DD, Knowles SK, Do KA, Wang X, Sage EH, Smith JW, Arap W, Pasqualini R. Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin. Cancer. 115: 1753-64. PMID 19224553 DOI: 10.1002/Cncr.24170  0.328
2009 Haddadin RI, Oh DJ, Kang MH, Filippopoulos T, Gupta M, Hart L, Sage EH, Rhee DJ. SPARC-null mice exhibit lower intraocular pressures. Investigative Ophthalmology & Visual Science. 50: 3771-7. PMID 19168904 DOI: 10.1167/Iovs.08-2489  0.338
2009 Schellings MW, Vanhoutte D, Swinnen M, Cleutjens JP, Debets J, van Leeuwen RE, d'Hooge J, Van de Werf F, Carmeliet P, Pinto YM, Sage EH, Heymans S. Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction. The Journal of Experimental Medicine. 206: 113-23. PMID 19103879 DOI: 10.1084/Jem.20081244  0.388
2009 Nie J, Sage EH. SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling. The Journal of Biological Chemistry. 284: 1279-90. PMID 18990699 DOI: 10.1074/Jbc.M808285200  0.441
2008 Gruber HE, Bornstein P, Sage EH, Ingram JA, Zinchenko N, Norton HJ, Hanley EN. Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc. Arthritis Research & Therapy. 10: R96. PMID 18718009 DOI: 10.1186/Ar2483  0.386
2008 Nie J, Chang B, Traktuev DO, Sun J, March K, Chan L, Sage EH, Pasqualini R, Arap W, Kolonin MG. IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells. Stem Cells (Dayton, Ohio). 26: 2735-45. PMID 18583538 DOI: 10.1634/Stemcells.2008-0212  0.353
2008 Weaver MS, Workman G, Sage EH. The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase. The Journal of Biological Chemistry. 283: 22826-37. PMID 18503049 DOI: 10.1074/Jbc.M706563200  0.362
2008 Golembieski WA, Thomas SL, Schultz CR, Yunker CK, McClung HM, Lemke N, Cazacu S, Barker T, Sage EH, Brodie C, Rempel SA. HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion. Glia. 56: 1061-75. PMID 18442089 DOI: 10.1002/Glia.20679  0.437
2008 Sullivan MM, Puolakkainen PA, Barker TH, Funk SE, Sage EH. Altered tissue repair in hevin-null mice: inhibition of fibroblast migration by a matricellular SPARC homolog. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 16: 310-9. PMID 18318815 DOI: 10.1111/J.1524-475X.2008.00370.X  0.458
2008 Kzhyshkowska J, Gratchev A, Schmuttermaier C, Brundiers H, Krusell L, Mamidi S, Zhang J, Workman G, Sage EH, Anderle C, Sedlmayr P, Goerdt S. Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis. Journal of Immunology (Baltimore, Md. : 1950). 180: 3028-37. PMID 18292525 DOI: 10.4049/Jimmunol.180.5.3028  0.313
2008 Clark CJ, Sage EH. A prototypic matricellular protein in the tumor microenvironment--where there's SPARC, there's fire. Journal of Cellular Biochemistry. 104: 721-32. PMID 18253934 DOI: 10.1002/Jcb.21688  0.311
2007 Gotoh N, Perdue NR, Matsushima H, Sage EH, Yan Q, Clark JI. An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium. Investigative Ophthalmology & Visual Science. 48: 4679-87. PMID 17898292 DOI: 10.1167/Iovs.07-0091  0.466
2007 Liu L, Ratner BD, Sage EH, Jiang S. Endothelial cell migration on surface-density gradients of fibronectin, VEGF, or both proteins. Langmuir : the Acs Journal of Surfaces and Colloids. 23: 11168-73. PMID 17892312 DOI: 10.1021/La701435X  0.427
2007 Rentz TJ, Poobalarahi F, Bornstein P, Sage EH, Bradshaw AD. SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts. The Journal of Biological Chemistry. 282: 22062-71. PMID 17522057 DOI: 10.1074/Jbc.M700167200  0.692
2007 Esposito I, Kayed H, Keleg S, Giese T, Sage EH, Schirmacher P, Friess H, Kleeff J. Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer. Neoplasia (New York, N.Y.). 9: 8-17. PMID 17325739 DOI: 10.1593/Neo.06646  0.371
2007 Tian J, Paquette-Straub C, Sage EH, Funk SE, Patel V, Galileo D, McLane MA. Inhibition of melanoma cell motility by the snake venom disintegrin eristostatin. Toxicon : Official Journal of the International Society On Toxinology. 49: 899-908. PMID 17316731 DOI: 10.1016/J.Toxicon.2006.12.013  0.435
2007 Kelly KA, Allport JR, Yu AM, Sinh S, Sage EH, Gerszten RE, Weissleder R. SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration. Journal of Leukocyte Biology. 81: 748-56. PMID 17178915 DOI: 10.1189/Jlb.1105664  0.398
2007 Wang H, Chen S, Ratner BD, Sage EH, Jiang S. Capillary differentiation of endothelial cells on microgrooved surfaces Journal of Physical Chemistry C. 111: 14602-14606. DOI: 10.1021/Jp075746Z  0.4
2006 Chavey C, Boucher J, Monthouël-Kartmann MN, Sage EH, Castan-Laurell I, Valet P, Tartare-Deckert S, Van Obberghen E. Regulation of secreted protein acidic and rich in cysteine during adipose conversion and adipose tissue hyperplasia. Obesity (Silver Spring, Md.). 14: 1890-7. PMID 17135603 DOI: 10.1038/Oby.2006.220  0.406
2006 Järveläinen H, Puolakkainen P, Pakkanen S, Brown EL, Höök M, Iozzo RV, Sage EH, Wight TN. A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 14: 443-52. PMID 16939572 DOI: 10.1111/J.1743-6109.2006.00150.X  0.356
2006 Sullivan MM, Barker TH, Funk SE, Karchin A, Seo NS, Höök M, Sanders J, Starcher B, Wight TN, Puolakkainen P, Sage EH. Matricellular hevin regulates decorin production and collagen assembly. The Journal of Biological Chemistry. 281: 27621-32. PMID 16844696 DOI: 10.1074/Jbc.M510507200  0.45
2006 Kzhyshkowska J, Workman G, Cardó-Vila M, Arap W, Pasqualini R, Gratchev A, Krusell L, Goerdt S, Sage EH. Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC. Journal of Immunology (Baltimore, Md. : 1950). 176: 5825-32. PMID 16670288 DOI: 10.4049/Jimmunol.176.10.5825  0.425
2006 Emerson RO, Sage EH, Ghosh JG, Clark JI. Chaperone-like activity revealed in the matricellular protein SPARC. Journal of Cellular Biochemistry. 98: 701-5. PMID 16598771 DOI: 10.1002/Jcb.20867  0.381
2006 Nozaki M, Sakurai E, Raisler BJ, Baffi JZ, Witta J, Ogura Y, Brekken RA, Sage EH, Ambati BK, Ambati J. Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. The Journal of Clinical Investigation. 116: 422-9. PMID 16453023 DOI: 10.1172/Jci26316  0.324
2006 Hecht JT, Sage EH. Retention of the matricellular protein SPARC in the endoplasmic reticulum of chondrocytes from patients with pseudoachondroplasia. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 54: 269-74. PMID 16286662 DOI: 10.1369/Jhc.5C6834.2005  0.378
2006 Wang H, Workman G, Chen S, Barker TH, Ratner BD, Sage EH, Jiang S. Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM-40) binds to fibrinogen fragments D and E, but not to native fibrinogen. Matrix Biology : Journal of the International Society For Matrix Biology. 25: 20-6. PMID 16263253 DOI: 10.1016/J.Matbio.2005.09.004  0.355
2006 Weaver MS, Sage EH, Yan Q. Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitro. Journal of Cellular Biochemistry. 97: 423-32. PMID 16211577 DOI: 10.1002/Jcb.20654  0.507
2005 Yan Q, Perdue N, Blake D, Sage EH. Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsule. Investigative Ophthalmology & Visual Science. 46: 4652-60. PMID 16303962 DOI: 10.1167/Iovs.05-0460  0.38
2005 Wang H, Fertala A, Ratner BD, Sage EH, Jiang S. Identifying the SPARC binding sites on collagen I and procollagen I by atomic force microscopy. Analytical Chemistry. 77: 6765-71. PMID 16255572 DOI: 10.1021/Ac051349D  0.333
2005 Barker TH, Baneyx G, Cardó-Vila M, Workman GA, Weaver M, Menon PM, Dedhar S, Rempel SA, Arap W, Pasqualini R, Vogel V, Sage EH. SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity. The Journal of Biological Chemistry. 280: 36483-93. PMID 16115889 DOI: 10.1074/Jbc.M504663200  0.418
2005 Yan Q, Perdue N, Sage EH. Differential responses of human lens epithelial cells to intraocular lenses in vitro: hydrophobic acrylic versus PMMA or silicone discs. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv FüR Klinische Und Experimentelle Ophthalmologie. 243: 1253-62. PMID 15909158 DOI: 10.1007/S00417-005-1181-2  0.371
2005 Gruber HE, Sage EH, Norton HJ, Funk S, Ingram J, Hanley EN. Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouse. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1131-8. PMID 15879573 DOI: 10.1369/Jhc.5A6687.2005  0.394
2005 Puolakkainen PA, Bradshaw AD, Brekken RA, Reed MJ, Kyriakides T, Funk SE, Gooden MD, Vernon RB, Wight TN, Bornstein P, Sage EH. SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 571-81. PMID 15872050 DOI: 10.1369/Jhc.4A6425.2005  0.666
2005 Reed MJ, Bradshaw AD, Shaw M, Sadoun E, Han N, Ferara N, Funk S, Puolakkainen P, Sage EH. Enhanced angiogenesis characteristic of SPARC-null mice disappears with age. Journal of Cellular Physiology. 204: 800-7. PMID 15795937 DOI: 10.1002/jcp.20348  0.645
2005 Barker TH, Framson P, Puolakkainen PA, Reed M, Funk SE, Sage EH. Matricellular homologs in the foreign body response: hevin suppresses inflammation, but hevin and SPARC together diminish angiogenesis. The American Journal of Pathology. 166: 923-33. PMID 15743803 DOI: 10.1016/S0002-9440(10)62312-7  0.414
2005 Yan Q, Weaver M, Perdue N, Sage EH. Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells. Journal of Cellular Physiology. 203: 286-94. PMID 15534859 DOI: 10.1002/Jcp.20226  0.444
2004 Aycock RL, Bradshaw AC, Sage EH, Starcher B. Development of UV-induced squamous cell carcinomas is suppressed in the absence of SPARC. The Journal of Investigative Dermatology. 123: 592-9. PMID 15304102 DOI: 10.1111/J.0022-202X.2004.23316.X  0.382
2004 Framson PE, Sage EH. SPARC and tumor growth: where the seed meets the soil? Journal of Cellular Biochemistry. 92: 679-90. PMID 15211566 DOI: 10.1002/Jcb.20091  0.4
2004 Brekken RA, Sullivan MM, Workman G, Bradshaw AD, Carbon J, Siadak A, Murri C, Framson PE, Sage EH. Expression and characterization of murine hevin (SC1), a member of the SPARC family of matricellular proteins. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 52: 735-48. PMID 15150282 DOI: 10.1369/Jhc.3A6245.2004  0.711
2004 Sweetwyne MT, Brekken RA, Workman G, Bradshaw AD, Carbon J, Siadak AW, Murri C, Sage EH. Functional analysis of the matricellular protein SPARC with novel monoclonal antibodies. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 52: 723-33. PMID 15150281 DOI: 10.1369/Jhc.3A6153.2004  0.667
2004 Sullivan MM, Sage EH. Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family. The International Journal of Biochemistry & Cell Biology. 36: 991-6. PMID 15094114 DOI: 10.1016/J.Biocel.2004.01.017  0.405
2004 Francki A, McClure TD, Brekken RA, Motamed K, Murri C, Wang T, Sage EH. SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells. Journal of Cellular Biochemistry. 91: 915-25. PMID 15034927 DOI: 10.1002/Jcb.20008  0.352
2004 Järveläinen H, Vernon RB, Gooden MD, Francki A, Lara S, Johnson PY, Kinsella MG, Sage EH, Wight TN. Overexpression of decorin by rat arterial smooth muscle cells enhances contraction of type I collagen in vitro. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 67-72. PMID 14615389 DOI: 10.1161/01.Atv.0000107026.98626.3B  0.353
2003 Sage EH. Purification of SPARC/osteonectin. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 10.11. PMID 18228415 DOI: 10.1002/0471143030.cb1011s17  0.345
2003 Rhee DJ, Fariss RN, Brekken R, Sage EH, Russell P. The matricellular protein SPARC is expressed in human trabecular meshwork. Experimental Eye Research. 77: 601-7. PMID 14550402 DOI: 10.1016/S0014-4835(03)00190-8  0.372
2003 Motamed K, Blake DJ, Angello JC, Allen BL, Rapraeger AC, Hauschka SD, Sage EH. Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: a role for protein kinase A. Journal of Cellular Biochemistry. 90: 408-23. PMID 14505356 DOI: 10.1002/Jcb.10645  0.433
2003 Sage EH, Reed M, Funk SE, Truong T, Steadele M, Puolakkainen P, Maurice DH, Bassuk JA. Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesis. The Journal of Biological Chemistry. 278: 37849-57. PMID 12867428 DOI: 10.1074/Jbc.M302946200  0.395
2003 Delany AM, Kalajzic I, Bradshaw AD, Sage EH, Canalis E. Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Endocrinology. 144: 2588-96. PMID 12746322 DOI: 10.1210/En.2002-221044  0.667
2003 Bradshaw AD, Graves DC, Motamed K, Sage EH. SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. Proceedings of the National Academy of Sciences of the United States of America. 100: 6045-50. PMID 12721366 DOI: 10.1073/pnas.1030790100  0.644
2003 Taneda S, Pippin JW, Sage EH, Hudkins KL, Takeuchi Y, Couser WG, Alpers CE. Amelioration of diabetic nephropathy in SPARC-null mice. Journal of the American Society of Nephrology : Jasn. 14: 968-80. PMID 12660331 DOI: 10.1097/01.Asn.0000054498.83125.90  0.378
2003 Yan Q, Blake D, Clark JI, Sage EH. Expression of the matricellular protein SPARC in murine lens: SPARC is necessary for the structural integrity of the capsular basement membrane. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 51: 503-11. PMID 12642629 DOI: 10.1177/002215540305100412  0.483
2003 Brekken RA, Puolakkainen P, Graves DC, Workman G, Lubkin SR, Sage EH. Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM. The Journal of Clinical Investigation. 111: 487-95. PMID 12588887 DOI: 10.1172/Jci16804  0.395
2003 Francki A, Motamed K, McClure TD, Kaya M, Murri C, Blake DJ, Carbon JG, Sage EH. SPARC regulates cell cycle progression in mesangial cells via its inhibition of IGF-dependent signaling. Journal of Cellular Biochemistry. 88: 802-11. PMID 12577314 DOI: 10.1002/Jcb.10424  0.424
2003 Puolakkainen P, Bradshaw AD, Kyriakides TR, Reed M, Brekken R, Wight T, Bornstein P, Ratner B, Sage EH. Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials. The American Journal of Pathology. 162: 627-35. PMID 12547720 DOI: 10.1016/S0002-9440(10)63856-4  0.658
2003 Reed MJ, Koike T, Sadoun E, Sage EH, Puolakkainen P. Inhibition of TIMP1 enhances angiogenesis in vivo and cell migration in vitro. Microvascular Research. 65: 9-17. PMID 12535866 DOI: 10.1016/S0026-2862(02)00026-2  0.425
2003 Sage EH, Bradshaw AD, Brekken R. SPARC, a Matricellular Protein That Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology Extracellular Matrix and the Liver: Approach to Gene Therapy. 75-85. DOI: 10.1016/B978-012525251-5/50006-3  0.322
2002 Alpers CE, Hudkins KL, Segerer S, Sage EH, Pichler R, Couser WG, Johnson RJ, Bassuk JA. Localization of SPARC in developing, mature, and chronically injured human allograft kidneys. Kidney International. 62: 2073-86. PMID 12427131 DOI: 10.1046/J.1523-1755.2002.00680.X  0.417
2002 Bornstein P, Sage EH. Matricellular proteins: extracellular modulators of cell function. Current Opinion in Cell Biology. 14: 608-16. PMID 12231357 DOI: 10.1016/S0955-0674(02)00361-7  0.431
2002 Netherton SJ, Jimmo SL, Palmer D, Tilley DG, Dunkerley HA, Raymond DR, Russell JC, Absher PM, Sage EH, Vernon RB, Maurice DH. Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease. Diabetes. 51: 1194-200. PMID 11916944 DOI: 10.2337/Diabetes.51.4.1194  0.31
2002 Motamed K, Funk SE, Koyama H, Ross R, Raines EW, Sage EH. Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors. Journal of Cellular Biochemistry. 84: 759-71. PMID 11835401 DOI: 10.1002/Jcb.10095  0.432
2002 Bradshaw AD, Reed MJ, Sage EH. SPARC-null mice exhibit accelerated cutaneous wound closure. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 50: 1-10. PMID 11748289 DOI: 10.1177/002215540205000101  0.672
2001 Bradshaw AD, Reed MJ, Carbon JG, Pinney E, Brekken RA, Sage EH. Increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges in SPARC-null mice. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 9: 522-30. PMID 11896995 DOI: 10.1046/J.1524-475X.2001.00522.X  0.69
2001 Francki A, Sage EH. SPARC and the kidney glomerulus: matricellular proteins exhibit diverse functions under normal and pathological conditions. Trends in Cardiovascular Medicine. 11: 32-7. PMID 11413050  0.318
2001 Bradshaw AD, Sage EH. SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. The Journal of Clinical Investigation. 107: 1049-54. PMID 11342565 DOI: 10.1172/Jci12939  0.687
2001 Sage EH. Regulation of interactions between cells and extracellular matrix: a command performance on several stages. The Journal of Clinical Investigation. 107: 781-3. PMID 11285292 DOI: 10.1172/Jci12683  0.496
2001 Yan Q, Li Y, Hendrickson A, Sage EH. Regulation of retinal capillary cells by basic fibroblast growth factor, vascular endothelial growth factor, and hypoxia. In Vitro Cellular & Developmental Biology. Animal. 37: 45-9. PMID 11249204 DOI: 10.1290/1071-2690(2001)037<0045:Rorccb>2.0.Co;2  0.403
2001 Brekken RA, Sage EH. SPARC, a matricellular protein: at the crossroads of cell-matrix communication. Matrix Biology : Journal of the International Society For Matrix Biology. 19: 816-27. PMID 11223341 DOI: 10.1016/s0945-053x(00)00133-5  0.398
2001 Brekken RA, Sage EH. SPARC, a matricellular protein: at the crossroads of cell-matrix. Matrix Biology : Journal of the International Society For Matrix Biology. 19: 569-80. PMID 11102747 DOI: 10.1016/S0945-053X(00)00105-0  0.496
2000 Bradshaw AD, Bassuk JA, Francki A, Sage EH. Expression and purification of recombinant human SPARC produced by baculovirus. Molecular Cell Biology Research Communications : McBrc. 3: 345-51. PMID 11032756 DOI: 10.1006/Mcbr.2000.0237  0.699
2000 Norose K, Lo WK, Clark JI, Sage EH, Howe CC. Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interface. Experimental Eye Research. 71: 295-307. PMID 10973738 DOI: 10.1006/Exer.2000.0884  0.413
2000 Gilbert RE, Cox AJ, Kelly DJ, Wilkinson-Berka JL, Sage EH, Jerums G, Cooper ME. Localization of secreted protein acidic and rich in cysteine (SPARC) expression in the rat eye. Connective Tissue Research. 40: 295-303. PMID 10757117 DOI: 10.3109/03008209909000707  0.44
2000 Bassuk JA, Pichler R, Rothmier JD, Pippen J, Gordon K, Meek RL, Bradshaw AD, Lombardi D, Strandjord TP, Reed M, Sage EH, Couser WG, Johnson R. Induction of TGF-beta1 by the matricellular protein SPARC in a rat model of glomerulonephritis. Kidney International. 57: 117-28. PMID 10620193 DOI: 10.1046/J.1523-1755.2000.00811.X  0.589
1999 Yan Q, Sage EH. SPARC, a matricellular glycoprotein with important biological functions. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 47: 1495-506. PMID 10567433 DOI: 10.1177/002215549904701201  0.482
1999 Francki A, Bradshaw AD, Bassuk JA, Howe CC, Couser WG, Sage EH. SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells. The Journal of Biological Chemistry. 274: 32145-52. PMID 10542250 DOI: 10.1074/Jbc.274.45.32145  0.695
1999 Puolakkainen P, Reed M, Vento P, Sage EH, Kiviluoto T, Kivilaakso E. Expression of SPARC (secreted protein, acidic and rich in cysteine) in healing intestinal anastomoses and short bowel syndrome in rats. Digestive Diseases and Sciences. 44: 1554-64. PMID 10492132 DOI: 10.1023/A:1026602708263  0.402
1999 Strandjord TP, Madtes DK, Weiss DJ, Sage EH. Collagen accumulation is decreased in SPARC-null mice with bleomycin-induced pulmonary fibrosis. The American Journal of Physiology. 277: L628-35. PMID 10484471 DOI: 10.1152/Ajplung.1999.277.3.L628  0.423
1999 Huynh MH, Sage EH, Ringuette M. A calcium-binding motif in SPARC/osteonectin inhibits chordomesoderm cell migration during Xenopus laevis gastrulation: evidence of counter-adhesive activity in vivo. Development, Growth & Differentiation. 41: 407-18. PMID 10466928 DOI: 10.1046/J.1440-169X.1999.00443.X  0.345
1999 Boehm JR, Kutz SM, Sage EH, Staiano-Coico L, Higgins PJ. Growth state-dependent regulation of plasminogen activator inhibitor type-1 gene expression during epithelial cell stimulation by serum and transforming growth factor-beta1. Journal of Cellular Physiology. 181: 96-106. PMID 10457357 DOI: 10.1002/(Sici)1097-4652(199910)181:1<96::Aid-Jcp10>3.0.Co;2-I  0.388
1999 Gooden MD, Vernon RB, Bassuk JA, Sage EH. Cell cycle-dependent nuclear location of the matricellular protein SPARC: association with the nuclear matrix. Journal of Cellular Biochemistry. 74: 152-67. PMID 10404386 DOI: 10.1002/(SICI)1097-4644(19990801)74:2<152::AID-JCB2>3.0.CO;2-4  0.361
1999 Bradshaw AD, Francki A, Motamed K, Howe C, Sage EH. Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation. Molecular Biology of the Cell. 10: 1569-79. PMID 10233163 DOI: 10.1091/Mbc.10.5.1569  0.692
1999 Bassuk JA, Birkebak T, Rothmier JD, Clark JM, Bradshaw A, Muchowski PJ, Howe CC, Clark JI, Sage EH. Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation Experimental Eye Research. 68: 321-331. PMID 10079140 DOI: 10.1006/Exer.1998.0608  0.415
1999 Redlitz A, Daum G, Sage EH. Angiostatin diminishes activation of the mitogen-activated protein kinases ERK-1 and ERK-2 in human dermal microvascular endothelial cells. Journal of Vascular Research. 36: 28-34. PMID 10050071 DOI: 10.1159/000025623  0.325
1999 Vernon RB, Sage EH. A novel, quantitative model for study of endothelial cell migration and sprout formation within three-dimensional collagen matrices. Microvascular Research. 57: 118-33. PMID 10049660 DOI: 10.1006/Mvre.1998.2122  0.419
1998 Yan Q, Sage EH, Hendrickson AE. SPARC is expressed by ganglion cells and astrocytes in bovine retina. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 46: 3-10. PMID 10712100 DOI: 10.1177/002215549804600102  0.388
1998 Motamed K, Sage EH. SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway. Journal of Cellular Biochemistry. 70: 543-52. PMID 9712151 DOI: 10.1002/(Sici)1097-4644(19980915)70:4<543::Aid-Jcb10>3.0.Co;2-I  0.395
1998 Bagavandoss P, Sage EH, Vernon RB. Secreted protein, acidic and rich in cysteine (SPARC) and thrombospondin in the developing follicle and corpus luteum of the rat. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 46: 1043-49. PMID 9705970 DOI: 10.1177/002215549804600908  0.452
1998 Arthur WT, Vernon RB, Sage EH, Reed MJ. Growth factors reverse the impaired sprouting of microvessels from aged mice. Microvascular Research. 55: 260-70. PMID 9657926 DOI: 10.1006/Mvre.1998.2078  0.384
1998 Yan Q, Sage EH. Transforming growth factor-beta1 induces apoptotic cell death in cultured retinal endothelial cells but not pericytes: association with decreased expression of p21waf1/cip1. Journal of Cellular Biochemistry. 70: 70-83. PMID 9632109 DOI: 10.1002/(Sici)1097-4644(19980701)70:1<70::Aid-Jcb8>3.0.Co;2-0  0.344
1998 Damjanovski S, Huynh MH, Motamed K, Sage EH, Ringuette M. Regulation of SPARC expression during early Xenopus development: evolutionary divergence and conservation of DNA regulatory elements between amphibians and mammals. Development Genes and Evolution. 207: 453-61. PMID 9510540 DOI: 10.1007/S004270050136  0.369
1997 Shankavaram UT, DeWitt DL, Funk SE, Sage EH, Wahl LM. Regulation of human monocyte matrix metalloproteinases by SPARC. Journal of Cellular Physiology. 173: 327-34. PMID 9369945 DOI: 10.1002/(Sici)1097-4652(199712)173:3<327::Aid-Jcp4>3.0.Co;2-P  0.356
1997 Soderling JA, Reed MJ, Corsa A, Sage EH. Cloning and expression of murine SC1, a gene product homologous to SPARC Journal of Histochemistry and Cytochemistry. 45: 823-435. PMID 9199668 DOI: 10.1177/002215549704500607  0.431
1997 Damjanovski S, Karp X, Funk S, Sage EH, Ringuette MJ. Ectopic expression of SPARC in Xenopus embryos interferes with tissue morphogenesis: identification of a bioactive sequence in the C-terminal EF hand. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 45: 643-55. PMID 9154151 DOI: 10.1177/002215549704500502  0.337
1997 Motamed K, Sage EH. Regulation of vascular morphogenesis by the matricellular protein SPARC. Kidney International. 51: 1383-7. PMID 9150448 DOI: 10.1038/Ki.1997.189  0.452
1997 Sibinga NE, Foster LC, Hsieh CM, Perrella MA, Lee WS, Endege WO, Sage EH, Lee ME, Haber E. Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury. Circulation Research. 80: 532-41. PMID 9118484 DOI: 10.1161/01.Res.80.4.532  0.42
1997 Sage EH. Terms of attachment: SPARC and tumorigenesis. Nature Medicine. 3: 144-6. PMID 9018225 DOI: 10.1038/Nm0297-144  0.4
1997 Pichler RH, Hugo C, Shankland SJ, Reed MJ, Bassuk JA, Andoh TF, Lombardi DM, Schwartz SM, Bennett WM, Alpers CE, Sage EH, Johnson RJ, Couser WG. SPARC is expressed in renal interstitial fibrosis and in renal vascular injury. Kidney International. 50: 1978-89. PMID 8943481 DOI: 10.1038/Ki.1996.520  0.437
1997 Iruela-Arispe ML, Vernon RB, Wu H, Jaenisch R, Sage EH. Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 207: 171-83. PMID 8906420 DOI: 10.1002/(Sici)1097-0177(199610)207:2<171::Aid-Aja5>3.0.Co;2-E  0.499
1996 Bassuk JA, Braun LP, Motamed K, Baneyx F, Sage EH. Renaturation of SPARC expressed in Escherichia coli requires isomerization of disulfide bonds for recovery of biological activity. The International Journal of Biochemistry & Cell Biology. 28: 1031-43. PMID 8930126 DOI: 10.1016/1357-2725(96)00036-2  0.432
1996 Luther T, Flössel C, Mackman N, Bierhaus A, Kasper M, Albrecht S, Sage EH, Iruela-Arispe L, Grossmann H, Ströhlein A, Zhang Y, Nawroth PP, Carmeliet P, Loskutoff DJ, Müller M. Tissue factor expression during human and mouse development. The American Journal of Pathology. 149: 101-13. PMID 8686734  0.709
1996 Vernon RB, Sage EH. Contraction of fibrillar type I collagen by endothelial cells: a study in vitro. Journal of Cellular Biochemistry. 60: 185-97. PMID 8655629 DOI: 10.1002/(Sici)1097-4644(19960201)60:2<185::Aid-Jcb3>3.0.Co;2-T  0.49
1996 Iruela-Arispe ML, Porter P, Bornstein P, Sage EH. Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in the human endometrium. The Journal of Clinical Investigation. 97: 403-12. PMID 8567961 DOI: 10.1172/Jci118429  0.335
1996 Bassuk JA, Baneyx F, Vernon RB, Funk SE, Sage EH. Expression of biologically active human SPARC in Escherichia coli. Archives of Biochemistry and Biophysics. 325: 8-19. PMID 8554346 DOI: 10.1006/Abbi.1996.0002  0.403
1995 Puolakkainen PA, Reed MJ, Gombotz WR, Twardzik DR, Abrass IB, Sage EH. Acceleration of wound healing in aged rats by topical application of transforming growth factor-beta(1). Wound Repair and Regeneration. 3: 330-339. PMID 17173560 DOI: 10.1046/J.1524-475X.1995.T01-1-30314.X  0.351
1995 Porter PL, Sage EH, Lane TF, Funk SE, Gown AM. Distribution of SPARC in normal and neoplastic human tissue. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 43: 791-800. PMID 7622842 DOI: 10.1177/43.8.7622842  0.325
1995 Reed MJ, Iruela-Arispe L, O'Brien ER, Truong T, LaBell T, Bornstein P, Sage EH. Expression of thrombospondins by endothelial cells. Injury is correlated with TSP-1. The American Journal of Pathology. 147: 1068-80. PMID 7573352  0.737
1995 Seiffert D, Iruela-Arispe ML, Sage EH, Loskutoff DJ. Distribution of vitronectin mRNA during murine development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 203: 71-9. PMID 7544171 DOI: 10.1002/Aja.1002030108  0.337
1995 Vernon RB, Lara SL, Drake CJ, Iruela-Arispe ML, Angello JC, Little CD, Wight TN, Sage EH. Organized type I collagen influences endothelial patterns during "spontaneous angiogenesis in vitro": planar cultures as models of vascular development. In Vitro Cellular & Developmental Biology. Animal. 31: 120-31. PMID 7537585 DOI: 10.1007/Bf02633972  0.417
1995 Frizell E, Liu S, Abraham A, Ozaki I, Eghbali M, Sage EH, Zern MA. Expression of SPARC in normal and fibrotic livers Hepatology. 21: 847-854. DOI: 10.1002/Hep.1840210335  0.402
1994 Reed MJ, Vernon RB, Abrass IB, Sage EH. TGF-beta 1 induces the expression of type I collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors. Journal of Cellular Physiology. 158: 169-79. PMID 8263022 DOI: 10.1002/Jcp.1041580121  0.399
1994 Goldblum SE, Ding X, Funk SE, Sage EH. SPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function. Proceedings of the National Academy of Sciences of the United States of America. 91: 3448-52. PMID 8159767 DOI: 10.1073/pnas.91.8.3448  0.321
1994 Yost JC, Bell A, Seale R, Sage EH. Purification of biologically active SPARC expressed in Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 314: 50-63. PMID 7944407 DOI: 10.1006/abbi.1994.1411  0.365
1994 O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma Cell. 79: 315-328. PMID 7525077 DOI: 10.1016/0092-8674(94)90200-3  0.314
1994 Battegay EJ, Rupp J, Iruela-Arispe L, Sage EH, Pech M. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors. The Journal of Cell Biology. 125: 917-28. PMID 7514607 DOI: 10.1083/jcb.125.4.917  0.72
1993 Tremble PM, Lane TF, Sage EH, Werb Z. SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway. The Journal of Cell Biology. 121: 1433-44. PMID 8509459 DOI: 10.1083/Jcb.121.6.1433  0.397
1993 Iruela-Arispe ML, Liska DJ, Sage EH, Bornstein P. Differential expression of thrombospondin 1, 2, and 3 during murine development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 197: 40-56. PMID 8400410 DOI: 10.1002/Aja.1001970105  0.434
1993 Bassuk JA, Iruela-Arispe ML, Lane TF, Benson JM, Berg RA, Sage EH. Molecular analysis of chicken embryo SPARC (osteonectin). Febs Journal. 218: 117-127. PMID 7916692 DOI: 10.1111/J.1432-1033.1993.Tb18358.X  0.347
1993 Iruela-Arispe ML, Sage EH. Endothelial cells exhibiting angiogenesis in vitro proliferate in response to TGF-beta 1. Journal of Cellular Biochemistry. 52: 414-30. PMID 7693728 DOI: 10.1002/Jcb.240520406  0.401
1993 Järveläinen HT, Iruela-Arispe ML, Kinsella MG, Sandell LJ, Sage EH, Wight TN. Expression of decorin by sprouting bovine aortic endothelial cells exhibiting angiogenesis in vitro. Experimental Cell Research. 203: 395-401. PMID 1281110 DOI: 10.1016/0014-4827(92)90013-X  0.461
1992 Hasselaar P, Sage EH. SPARC antagonizes the effect of basic fibroblast growth factor on the migration of bovine aortic endothelial cells. Journal of Cellular Biochemistry. 49: 272-83. PMID 1644864 DOI: 10.1002/Jcb.240490310  0.466
1992 Sage EH. Modulation of endothelial cell shape by SPARC does not involve chelation of extracellular Ca2+ and Mg2+. Biochemistry and Cell Biology. 70: 56-62. PMID 1581032 DOI: 10.1139/O92-008  0.354
1992 Sage EH. Secretion of SPARC by endothelial cells transformed by polyoma middle T oncogene inhibits the growth of normal endothelial cells in vitro. Biochemistry and Cell Biology. 70: 579-592. PMID 1449724 DOI: 10.1139/O92-089  0.401
1992 Everitt EA, Sage EH. Expression of SPARC is correlated with altered morphologies in transfected F9 embryonal carcinoma cells. Experimental Cell Research. 199: 134-146. PMID 1310471 DOI: 10.1016/0014-4827(92)90471-J  0.401
1992 Everitt EA, Sage EH. Overexpression of SPARC in stably transfected F9 cells mediates attachment and spreading in Ca2+-deficient medium Biochemistry and Cell Biology. 70: 1368-1379. PMID 1299273 DOI: 10.1139/O92-185  0.332
1992 Iruela-Arispe ML, Chun LE, Sage EH. Structure and Biology of Type VIII Collagen. Trends in Glycoscience and Glycotechnology. 4: 188-199. DOI: 10.4052/Tigg.4.188  0.303
1991 Fouser L, Sage EH, Clark J, Bornstein P. Feedback regulation of collagen gene expression: a Trojan horse approach. Proceedings of the National Academy of Sciences of the United States of America. 88: 10158-62. PMID 1946435 DOI: 10.1073/Pnas.88.22.10158  0.32
1991 Fouser L, Iruela-Arispe L, Bornstein P, Sage EH. Transcriptional activity of the alpha 1(I)-collagen promoter is correlated with the formation of capillary-like structures by endothelial cells in vitro. The Journal of Biological Chemistry. 266: 18345-51. PMID 1917959  0.73
1991 Iruela-Arispe ML, Sage EH. Expression of type VIII collagen during morphogenesis of the chicken and mouse heart. Developmental Biology. 144: 107-18. PMID 1847345 DOI: 10.1016/0012-1606(91)90483-J  0.353
1991 Iruela-Arispe ML, Diglio CA, Sage EH. Modulation of extracellular matrix proteins by endothelial cells undergoing angiogenesis in vitro. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology. 11: 805-15. PMID 1712229 DOI: 10.1161/01.ATV.11.4.805  0.397
1977 Sage EH, Gray WR. Evolution of elastin structure. Advances in Experimental Medicine and Biology. 79: 291-312. PMID 868643  0.468
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