| Year |
Citation |
Score |
| 2015 |
Cueva JP, Roche C, Ostovar M, Kumar V, Clark MJ, Hillhouse TM, Lewis JW, Traynor JR, Husbands SM. C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors. Journal of Medicinal Chemistry. 58: 4242-9. PMID 25898137 DOI: 10.1021/Acs.Jmedchem.5B00130 |
0.389 |
|
| 2014 |
Kumar V, Clark MJ, Traynor JR, Lewis JW, Husbands SM. Pyrrolo- and pyridomorphinans: non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists. Bioorganic & Medicinal Chemistry. 22: 4067-72. PMID 24973818 DOI: 10.1016/j.bmc.2014.05.065 |
0.38 |
|
| 2014 |
Kumar V, Ridzwan IE, Grivas K, Lewis JW, Clark MJ, Meurice C, Jimenez-Gomez C, Pogozheva I, Mosberg H, Traynor JR, Husbands SM. Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity. Journal of Medicinal Chemistry. 57: 4049-57. PMID 24761755 DOI: 10.1021/Jm401964Y |
0.467 |
|
| 2013 |
Greedy BM, Bradbury F, Thomas MP, Grivas K, Cami-Kobeci G, Archambeau A, Bosse K, Clark MJ, Aceto M, Lewis JW, Traynor JR, Husbands SM. Orvinols with mixed kappa/mu opioid receptor agonist activity. Journal of Medicinal Chemistry. 56: 3207-16. PMID 23438330 DOI: 10.1021/Jm301543E |
0.456 |
|
| 2012 |
Moynihan HA, Derrick I, Broadbear JH, Greedy BM, Aceto MD, Harris LS, Purington LC, Thomas MP, Woods JH, Traynor JR, Husbands SM, Lewis JW. Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversible μ opioid receptor antagonist effects. Journal of Medicinal Chemistry. 55: 9868-74. PMID 23043264 DOI: 10.1021/jm301096s |
0.337 |
|
| 2009 |
Moynihan H, Jales AR, Greedy BM, Rennison D, Broadbear JH, Purington L, Traynor JR, Woods JH, Lewis JW, Husbands SM. 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. Journal of Medicinal Chemistry. 52: 1553-7. PMID 19253983 DOI: 10.1021/Jm8012272 |
0.471 |
|
| 2009 |
Cami-Kobeci G, Neal AP, Bradbury FA, Purington LC, Aceto MD, Harris LS, Lewis JW, Traynor JR, Husbands SM. Mixed kappa/mu opioid receptor agonists: the 6 beta-naltrexamines. Journal of Medicinal Chemistry. 52: 1546-52. PMID 19253970 DOI: 10.1021/Jm8015552 |
0.34 |
|
| 2008 |
Spagnolo B, Calo G, Polgar WE, Jiang F, Olsen CM, Berzetei-Gurske I, Khroyan TV, Husbands SM, Lewis JW, Toll L, Zaveri NT. Activities of mixed NOP and mu-opioid receptor ligands. British Journal of Pharmacology. 153: 609-19. PMID 18059322 DOI: 10.1038/Sj.Bjp.0707598 |
0.317 |
|
| 2007 |
Rennison D, Neal AP, Cami-Kobeci G, Aceto MD, Martinez-Bermejo F, Lewis JW, Husbands SM. Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands. Journal of Medicinal Chemistry. 50: 5176-82. PMID 17887741 DOI: 10.1021/Jm070255O |
0.438 |
|
| 2006 |
Rennison D, Moynihan H, Traynor JR, Lewis JW, Husbands SM. Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring. Journal of Medicinal Chemistry. 49: 6104-10. PMID 17004724 DOI: 10.1021/Jm060595U |
0.421 |
|
| 2006 |
Nieland NP, Moynihan HA, Carrington S, Broadbear J, Woods JH, Traynor JR, Husbands SM, Lewis JW. Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones. Journal of Medicinal Chemistry. 49: 5333-8. PMID 16913723 DOI: 10.1021/jm0604777 |
0.36 |
|
| 2005 |
Rennison D, Grundt P, Goodyer C, Lewis JW, Husbands SM. Formic acid catalysed rearrangement of 5beta-methyldihydrothevinols (= 3,6-dimethoxy-5,17-dimethyl-4,5-epoxy-6,14-ethanomorphinan-7-methanols): synthesis of new doubly bridged morphinan derivatives. Chemistry & Biodiversity. 2: 215-20. PMID 17191974 DOI: 10.1002/Cbdv.200590004 |
0.381 |
|
| 2005 |
Chauvignac C, Miller CN, Srivastava SK, Lewis JW, Husbands SM, Traynor JR. Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective kappa-opioid receptor antagonist. Journal of Medicinal Chemistry. 48: 1676-9. PMID 15743210 DOI: 10.1021/Jm049172N |
0.474 |
|
| 2005 |
Husbands SM, Neilan CL, Broadbear J, Grundt P, Breeden S, Aceto MD, Woods JH, Lewis JW, Traynor JR. BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism. European Journal of Pharmacology. 509: 117-25. PMID 15733546 DOI: 10.1016/j.ejphar.2004.12.035 |
0.374 |
|
| 2005 |
Wu H, Bernard D, Chen W, Strahan GD, Deschamps JR, Parrish DA, Lewis JW, MacKerell AD, Coop A. Functionalization of the 6,14-bridge of the orvinols. 2. Preparation of 18- and 19-hydroxyl-substituted thevinols and their treatment with benzyl bromide. The Journal of Organic Chemistry. 70: 1907-10. PMID 15730320 DOI: 10.1021/Jo048388U |
0.536 |
|
| 2005 |
Shefali S, Srivastava SK, Husbands SM, Lewis JW. Extension of the Nenitzescu reaction to simple ketones provides an efficient route to 1'-alkyl-5'-hydroxynaltrindole analogues, potent and selective delta-opioid receptor antagonists. Journal of Medicinal Chemistry. 48: 635-8. PMID 15658877 DOI: 10.1021/Jm040853S |
0.479 |
|
| 2004 |
Srivastava SK, Shefali S, Miller CN, Aceto MD, Traynor JR, Lewis JW, Husbands SM. Effects of substitution on the pyrrole N atom in derivatives of tetrahydronaltrindole, tetrahydrooxymorphindole, and a related 4,5-epoxyphenylpyrrolomorphinan. Journal of Medicinal Chemistry. 47: 6645-8. PMID 15588100 DOI: 10.1021/Jm040817T |
0.459 |
|
| 2004 |
Grundt P, Williams IA, Lewis JW, Husbands SM. Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore. Journal of Medicinal Chemistry. 47: 5069-75. PMID 15456250 DOI: 10.1021/jm040807s |
0.384 |
|
| 2004 |
Neilan CL, Husbands SM, Breeden S, Ko MC, Aceto MD, Lewis JW, Woods JH, Traynor JR. Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist. European Journal of Pharmacology. 499: 107-16. PMID 15363957 DOI: 10.1016/j.ejphar.2004.07.097 |
0.376 |
|
| 2004 |
Lewis JW, Husbands SM. The orvinols and related opioids--high affinity ligands with diverse efficacy profiles. Current Pharmaceutical Design. 10: 717-32. PMID 15032698 DOI: 10.2174/1381612043453027 |
0.396 |
|
| 2003 |
Black SL, Chauvignac C, Grundt P, Miller CN, Wood S, Traynor JR, Lewis JW, Husbands SM. Guanidino N-substituted and N,N-disubstituted derivatives of the kappa-opioid antagonist GNTI. Journal of Medicinal Chemistry. 46: 5505-11. PMID 14640558 DOI: 10.1021/jm0309203 |
0.388 |
|
| 2003 |
Grundt P, Martinez-Bermejo F, Lewis JW, Husbands SM. Opioid binding and in vitro profiles of a series of 4-hdroxy-3-methoxyindolomorphinans. Transformation of a delta-selective ligand into a high affinity kappa-selective ligand by introduction of a 5,14-substituted bridge. Journal of Medicinal Chemistry. 46: 3174-7. PMID 12825957 DOI: 10.1021/jm030801n |
0.36 |
|
| 2003 |
Grundt P, Jales AR, Traynor JR, Lewis JW, Husbands SM. 14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles. Journal of Medicinal Chemistry. 46: 1563-6. PMID 12672258 DOI: 10.1021/jm021073r |
0.365 |
|
| 2003 |
Husbands SM, Lewis JW. Opioid ligands having delayed long-term antagonist activity: potential pharmacotherapies for opioid abuse. Mini Reviews in Medicinal Chemistry. 3: 137-44. PMID 12570846 DOI: 10.2174/1389557033405395 |
0.435 |
|
| 2003 |
Black SL, Jales AR, Brandt W, Lewis JW, Husbands SM. The role of the side chain in determining relative delta- and kappa-affinity in C5'-substituted analogues of naltrindole. Journal of Medicinal Chemistry. 46: 314-7. PMID 12519069 DOI: 10.1021/Jm020997B |
0.409 |
|
| 2002 |
Tyacke RJ, Robinson ES, Schnabel R, Lewis JW, Husbands SM, Nutt DJ, Hudson AL. N1'-fluoroethyl-naltrindole (BU97001) and N1'-fluoroethyl-(14-formylamino)-naltrindole (BU97018) potential delta-opioid receptor PET ligands. Nuclear Medicine and Biology. 29: 455-62. PMID 12031880 DOI: 10.1016/S0969-8051(02)00300-1 |
0.425 |
|
| 2002 |
Srivastava SK, Husbands SM, Aceto MD, Miller CN, Traynor JR, Lewis JW. 4'-Arylpyrrolomorphinans: effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity. Journal of Medicinal Chemistry. 45: 537-40. PMID 11784158 DOI: 10.1021/Jm010841W |
0.405 |
|
| 2002 |
Shefali, Srivastava SK, Hall LD, Lewis JW, Husbands SM. Michael reactions of benzylimines derived from morphinan-6-ones: Synthesis of pyrrolo- and pyridinomorphinans Helvetica Chimica Acta. 85: 1790-1799. DOI: 10.1002/1522-2675(200206)85:6<1790::Aid-Hlca1790>3.0.Co;2-G |
0.391 |
|
| 2001 |
Zaveri N, Polgar WE, Olsen CM, Kelson AB, Grundt P, Lewis JW, Toll L. Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors. European Journal of Pharmacology. 428: 29-36. PMID 11779034 DOI: 10.1016/S0014-2999(01)01282-1 |
0.428 |
|
| 2001 |
Husbands SM, Glennon RA, Gorgerat S, Gough R, Tyacke R, Crosby J, Nutt DJ, Lewis JW, Hudson AL. beta-carboline binding to imidazoline receptors. Drug and Alcohol Dependence. 64: 203-8. PMID 11543990 DOI: 10.1016/S0376-8716(01)00123-5 |
0.326 |
|
| 2001 |
Clayson J, Jales A, Tyacke RJ, Hudson AL, Nutt DJ, Lewis JW, Husbands SM. Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole. Bioorganic & Medicinal Chemistry Letters. 11: 939-43. PMID 11294396 DOI: 10.1016/S0960-894X(01)00112-3 |
0.43 |
|
| 2001 |
McIntyre BG, Martínez Bermejo F, Srivastava SK, Husbands SM, Lewis JW, Crosby J, Simpson TJ. Solid phase synthesis of 4-hydroxycinnamic acid and its derivatives for potential use in combinatorial chemistry: a novel route for the synthesis of 4-hydroxycinnamoyl coenzyme A and NMDA receptor antagonists. Combinatorial Chemistry & High Throughput Screening. 4: 111-4. PMID 11281828 DOI: 10.2174/1386207013331336 |
0.328 |
|
| 2000 |
Jales AR, Husbands SM, Lewis JW. Selective kappa-opioid antagonists related to naltrindole. Effect of side-chain spacer in the 5'-amidinoalkyl series. Bioorganic & Medicinal Chemistry Letters. 10: 2259-61. PMID 11055333 DOI: 10.1016/S0960-894X(00)00433-9 |
0.459 |
|
| 2000 |
Derrick I, Neilan CL, Andes J, Husbands SM, Woods JH, Traynor JR, Lewis JW. 3-Deoxyclocinnamox: the first high-affinity, nonpeptide mu-opioid antagonist lacking a phenolic hydroxyl group. Journal of Medicinal Chemistry. 43: 3348-50. PMID 10966754 DOI: 10.1021/Jm0009641 |
0.464 |
|
| 2000 |
Broom DC, Guo L, Coop A, Husbands SM, Lewis JW, Woods JH, Traynor JR. BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice. The Journal of Pharmacology and Experimental Therapeutics. 294: 1195-200. PMID 10945877 |
0.616 |
|
| 2000 |
Briscoe RJ, Winger G, Lewis JW, Woods JH. Methoclocinnamox: time course of changes in alfentanil-reinforced responding in rhesus monkeys. Psychopharmacology. 148: 393-9. PMID 10928312 DOI: 10.1007/S002130050068 |
0.372 |
|
| 2000 |
Coop A, Norton CL, Berzetei-Gurske I, Burnside J, Toll L, Husbands SM, Lewis JW. Structural determinants of opioid activity in the orvinols and related structures: ethers of orvinol and isoorvinol. Journal of Medicinal Chemistry. 43: 1852-7. PMID 10794701 DOI: 10.1021/Jm990951R |
0.613 |
|
| 2000 |
Kishioka S, Paronis CA, Lewis JW, Woods JH. Buprenorphine and methoclocinnamox: agonist and antagonist effects on respiratory function in rhesus monkeys. European Journal of Pharmacology. 391: 289-97. PMID 10729371 DOI: 10.1016/S0014-2999(00)00039-X |
0.411 |
|
| 2000 |
Husbands SM, Lewis JW. Structural determinants of efficacy for kappa opioid receptors in the orvinol series: 7,7-spiro analogues of buprenorphine. Journal of Medicinal Chemistry. 43: 139-41. PMID 10649968 DOI: 10.1021/Jm991165P |
0.451 |
|
| 2000 |
Derrick I, Coop A, Al-Mousawi SM, Husbands SM, Lewis JW. Perchloric acid induced epimerisation of the thevinones: An improved synthesis of 7β-dihydrothevinones Tetrahedron Letters. 41: 7571-7576. DOI: 10.1016/S0040-4039(00)01300-9 |
0.576 |
|
| 2000 |
Derrick I, Husbands SM, Broadbear J, Traynor JR, Woods JH, Lewis JW. Cinnamoyl derivatives of 7a-amino- and 7a-(aminomethyl)- N-(cyclopropylmethyl)-6,14-endo-ethanotetrahydronororipavines are high-potency opioid antagonists Helvetica Chimica Acta. 83: 3122-3130. DOI: 10.1002/1522-2675(20001220)83:12<3122::Aid-Hlca3122>3.0.Co;2-2 |
0.414 |
|
| 2000 |
Coop A, Berzetei-Gurske I, Burnside J, Toll L, Traynor JR, Husbands SM, Lewis JW. Structural determinants of opioid activity in the orvinols and related structures. Ethers of 7,8-cyclopenta-fused analogs of buprenorphine Helvetica Chimica Acta. 83: 687-693. DOI: 10.1002/(Sici)1522-2675(20000412)83:4<687::Aid-Hlca687>3.0.Co;2-W |
0.622 |
|
| 1999 |
Traynor JR, Guo L, Coop A, Lewis JW, Woods JH. Ring-constrained orvinols as analogs of buprenorphine: differences in opioid activity related to configuration of C(20) hydroxyl group. The Journal of Pharmacology and Experimental Therapeutics. 291: 1093-9. PMID 10565829 |
0.62 |
|
| 1999 |
Hudson AL, Gough R, Tyacke R, Lione L, Lalies M, Lewis J, Husbands S, Knight P, Murray F, Hutson P, Nutt DJ. Novel selective compounds for the investigation of imidazoline receptors. Annals of the New York Academy of Sciences. 881: 81-91. PMID 10415900 DOI: 10.1111/J.1749-6632.1999.Tb09344.X |
0.377 |
|
| 1999 |
Husbands SM, Breeden SW, Grivas K, Lewis JW. Ring constrained analogues of the orvinols: the furanomorphides. Bioorganic & Medicinal Chemistry Letters. 9: 831-4. PMID 10206545 DOI: 10.1016/S0960-894X(99)00085-2 |
0.444 |
|
| 1999 |
Breeden SW, Coop A, Husbands SM, Lewis JW. 6-O-demethylation of the thevinols with lithium aluminium hydride: Selective demethylation of a tertiary alkyl methyl ether in the presence of an aryl methyl ether Helvetica Chimica Acta. 82: 1978-1980. DOI: 10.1002/(Sici)1522-2675(19991110)82:11<1978::Aid-Hlca1978>3.0.Co;2-Q |
0.566 |
|
| 1999 |
Bermejo FM, Husbands SM, Lewis JW. Derivatives of flavonepenthone: Kappa opioid receptor selectivity in an N-methylmorphinan Helvetica Chimica Acta. 82: 1721-1727. DOI: 10.1002/(Sici)1522-2675(19991006)82:10<1721::Aid-Hlca1721>3.0.Co;2-F |
0.474 |
|
| 1998 |
Husbands SM, Sadd J, Broadbear JH, Woods JH, Martin J, Traynor JR, Aceto MD, Bowman ER, Harris LS, Lewis JW. 3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy. Journal of Medicinal Chemistry. 41: 3493-8. PMID 9719602 DOI: 10.1021/Jm9810248 |
0.5 |
|
| 1998 |
Coop A, Janetka JW, Lewis JW, Rice KC. L-Selectride as a general reagent for the O-demethylation and N-decarbomethoxylation of opium alkaloids and derivatives Journal of Organic Chemistry. 63: 4392-4396. DOI: 10.1021/Jo9801972 |
0.616 |
|
| 1997 |
Hudson AL, Chapleo CB, Lewis JW, Husbands S, Grivas K, Mallard NJ, Nutt DJ. Identification of ligands selective for central I2-imidazoline binding sites. Neurochemistry International. 30: 47-53. PMID 9116587 DOI: 10.1016/S0197-0186(96)00037-X |
0.374 |
|
| 1997 |
Zernig G, Lewis JW, Woods JH. Clocinnamox inhibits the intravenous self-administration of opioid agonists in rhesus monkeys: comparison with effects on opioid agonist-mediated antinociception. Psychopharmacology. 129: 233-42. PMID 9084061 DOI: 10.1007/S002130050185 |
0.375 |
|
| 1996 |
Coop A, Lewis JW, Rice KC. Direct and Simple O-Demethylation of Thebaine to Oripavine. The Journal of Organic Chemistry. 61: 6774. PMID 11667567 DOI: 10.1021/Jo961473K |
0.571 |
|
| 1996 |
Derrick I, Lewis JW, Moynihan HA, Broadbear J, Woods JH. Potential irreversible ligands for opioid receptors. Cinnamoyl derivatives of beta-naltrexamine. The Journal of Pharmacy and Pharmacology. 48: 192-6. PMID 8935170 DOI: 10.1111/j.2042-7158.1996.tb07121.x |
0.341 |
|
| 1996 |
Butelman ER, Negus SS, Lewis JW, Woods JH. Clocinnamox antagonism of opioid suppression of schedule-controlled responding in rhesus monkeys. Psychopharmacology. 123: 320-4. PMID 8867870 DOI: 10.1007/Bf02246641 |
0.4 |
|
| 1996 |
Derrick I, Moynihan HA, Broadbear J, Woods JH, Lewis JW. 6N-Cinnamoyl-β-naltrexamine and its p-nitro derivative. High efficacy κ-opioid agonists with weak antagonist actions Bioorganic & Medicinal Chemistry Letters. 6: 167-172. DOI: 10.1016/0960-894X(95)00583-F |
0.429 |
|
| 1996 |
Broadbear JH, Lewis JW, Woods JH. Alternative pharmacotherapies in the treatment of opioid addiction European Neuropsychopharmacology. 6: 120. DOI: 10.1016/0924-977X(96)87855-2 |
0.386 |
|
| 1995 |
Nutt DJ, French N, Handley S, Hudson A, Husbands S, Jackson H, Jordan S, Lalies MD, Lewis J, Lione L, Mallard N, Pratt J. Functional studies of specific imidazoline-2 receptor ligands. Annals of the New York Academy of Sciences. 763: 125-139. PMID 7677321 DOI: 10.1111/J.1749-6632.1995.Tb32397.X |
0.304 |
|
| 1995 |
Zernig G, Issaevitch T, Broadbear JH, Burke TF, Lewis JW, Brine GA, Woods JH. Receptor reserve and affinity of mu opioid agonists in mouse antinociception: correlation with receptor binding. Life Sciences. 57: 2113-25. PMID 7475964 DOI: 10.1016/0024-3205(95)02204-V |
0.452 |
|
| 1995 |
Zernig G, Broadbear J, Lewis JW, Brine GA, Woods JH. Opioid Agonist Effects on Mouse Writhing After Irreversible Mu Receptor Blockade With Clocinnamox Experimental and Clinical Psychopharmacology. 3: 323-329. DOI: 10.1037/1064-1297.3.4.323 |
0.455 |
|
| 1995 |
Husbands SM, Lewis JW. Morphinan cyclic imines and pyrrolidines containing a constrained phenyl group: High affinity opioid agonists Bioorganic and Medicinal Chemistry Letters. 5: 2969-2974. DOI: 10.1016/0960-894X(95)00522-1 |
0.471 |
|
| 1995 |
Coop A, Grivas K, Husbands S, Lewis JW, Porter J. Ring constrained analogues of the thevinones; Diels-Alder reactions of thebaines with 1-indenone and methylene cycloalkanones Tetrahedron Letters. 36: 1689-1692. DOI: 10.1016/0040-4039(95)00046-F |
0.531 |
|
| 1995 |
Coop A, Grivas K, Husbands S, Lewis JW. Methylation of the enolates of thevinone and some analogues Tetrahedron. 51: 9681-9698. DOI: 10.1016/0040-4020(95)00553-K |
0.529 |
|
| 1994 |
Zernig G, Butelman ER, Lewis JW, Walker EA, Woods JH. In vivo determination of mu opioid receptor turnover in rhesus monkeys after irreversible blockade with clocinnamox. The Journal of Pharmacology and Experimental Therapeutics. 269: 57-65. PMID 8169852 |
0.358 |
|
| 1994 |
Burke TF, Woods JH, Lewis JW, Medzihradsky F. Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice. The Journal of Pharmacology and Experimental Therapeutics. 271: 715-21. PMID 7965787 |
0.333 |
|
| 1994 |
Zernig G, Burke T, Lewis J, Woods J. Clocinnamox blocks only mu receptors irreversibly: Binding evidence Regulatory Peptides. 54: 343-344. DOI: 10.1016/0167-0115(94)90529-0 |
0.375 |
|
| 1994 |
Zernig G, Butelman ER, Lewis J, Woods JH. In vivo determination of μ opioid receptor reserve and turnover in rhesus monkeys after irreversible blockade with clocinnamox Regulatory Peptides. 53: S59-S60. DOI: 10.1016/0167-0115(94)90240-2 |
0.473 |
|
| 1993 |
Barton JW, Coop A, Lewis JW. Diels-Alder reactions of thebaines with cycloalkenones; Lithium tetrafluoroborate as a novel diels-alder catalyst Tetrahedron Letters. 34: 6777-6778. DOI: 10.1016/S0040-4039(00)61699-4 |
0.516 |
|
| 1973 |
Lewis JW, Readhead MJ, Smith AC. Novel analgetics and molecular rearrangements in the morphine-thebaine group. 28. Derivatives of 6,14-endo-etheno-7-oxo-6,7,8,14-tetrahydrothebaine and 6,14-endo-etheno-6,7,8,14-tetrahydrothebaine. Journal of Medicinal Chemistry. 16: 9-12. PMID 4682205 DOI: 10.1021/Jm00259A003 |
0.392 |
|
| 1973 |
Lewis JW, Readhead MJ. Novel analgetics and molecular rearrangements in the morphine-thebaine group. 29. Aryl and arylalkyl tertiary alcohols in the 6,14-endo-ethenotetrahydrothebaine series Journal of Medicinal Chemistry. 16: 84-85. PMID 4682204 DOI: 10.1021/Jm00259A024 |
0.336 |
|
| 1973 |
Lewis JW, Mayor PA, Haddlesey DI. Novel analgetics and molecular rearrangements in the morphine-thebaine group. 30. 16-Alkyl-6,14-endo-ethenotetrahydrothebaines. Journal of Medicinal Chemistry. 16: 12-4. PMID 4682192 DOI: 10.1021/Jm00259A004 |
0.385 |
|
| 1973 |
Lewis JW, Readhead MJ, Smith ACB. Neue Analgetica Und Molekuelumlagerungen In Der Morphin-Thebain-Reihe 28. Mitt. Derivate Von 6,14-Endo-Aetheno-7-Oxo-6,7,8,14-Tetra-Thebain Und 6,14-Aetheno-6,7,8,14-Tetrahydrothebain Cheminform. 4. DOI: 10.1002/Chin.197318483 |
0.416 |
|
| 1973 |
Lewis JW, Mayor PA, Haddlesey DI. Neue Analgetica Und Molekulare Umlagerungsrk. In Der Morphin-Thebain-Reihe 30. Mitt. 16-Alkyl-6,14-Endo-Aetheno-Tetrahydrothebaine Cheminform. 4. DOI: 10.1002/Chin.197318482 |
0.423 |
|
| 1972 |
Lewis JW, Readhead MJ, Smith ACB. Neue Analgetika Und Molekuelumlagerungen In Der Morphin-Thebain-Gruppe 26. Mitt. Rk. Des Adduktes Aus Thebain Mit 2-Chlor-Acrylonitril Cheminform. 3. DOI: 10.1002/Chin.197224455 |
0.351 |
|
| 1972 |
Haddlesey DI, Lewis JW, Mayor PA. Neue Analgetika Und Molekuelumlagerungen In Der Morphin-Thebain-Gruppe 25. Mitt. Substitution Am Piperidinring Von Derivaten Des 6,14-Endo-Aethenotetrahydrothebains Cheminform. 3. DOI: 10.1002/Chin.197224454 |
0.407 |
|
| 1972 |
Haddlesey DI, Lewis JW, Mayor PA, Young GR. Neue Analgetika Und Molekuelumlagerungen In Der Morphin-Thebain-Gruppe 24. Mitt. 15,16-Didehydro-6,14-Endo-Aetheno-6,7,8,14-Tetrahydro-Thebaine Und -Oripavine Cheminform. 3. DOI: 10.1002/Chin.197224453 |
0.401 |
|
| 1972 |
Bentley KW, Lewis JW, Smith ACB. Neue Analgetika Und Molekuelumlagerungen In Der Morphin-Thebain-Gruppe 23. Mitt. Addukte Von Thebain Mit Divinylsulfon Und Mit Methylvinylsulfon Cheminform. 3. DOI: 10.1002/Chin.197224452 |
0.384 |
|
| 1971 |
Lewis JW, Bentley KW, Cowan A. Narcotic analgesics and antagonists Annual Review of Pharmacology. 11: 241-270. PMID 4948499 DOI: 10.1146/annurev.pa.11.040171.001325 |
0.311 |
|
| 1971 |
Lewis JW, Readhead MJ, Selby IA, Smith ACB, Young CA. Neuartige Analgetika Und Molekuelumlagerungen In Der Morphin-Thebain-Gruppe 19. Mitt. Weitere Diels-Alder-Addukte Von Thebain Cheminform. 2. DOI: 10.1002/Chin.197126329 |
0.35 |
|
| 1970 |
Lewis JW, Readhead MJ. Novel analgetics and molecular rearrangements in the morphine-thebaine group. XVIII. 3-Deoxy-6,14-endo-etheno-6,7,8,14-tetrahydrooripavines Journal of Medicinal Chemistry. 13: 525-527. PMID 5441135 DOI: 10.1021/Jm00297A041 |
0.402 |
|
| 1970 |
Lewis JW, Rushworth WI. Novel analgesics and molecular rearrangements in the morphine-thebaine group. Part XVII. Compounds related to the thebaine-maleic anhydride adduct Journal of the Chemical Society C: Organic. 560-564. DOI: 10.1039/J39700000560 |
0.315 |
|
| 1970 |
Bentley KW, Bower JD, Lewis JW, Readhead MJ, Smith ACB, Young GR. Neue Analgetika Und Molekulare Umlagerungen In Der Morphin-Thebain-Gruppe 13. Mitt. 7-Aminomethyl-6,14-Endo-Aetheno-Tetrahydro-Thebaine Cheminform. 1. DOI: 10.1002/Chin.197003300 |
0.404 |
|
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