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Hollis D. Showalter - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Organic Chemistry, Biochemistry
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Liu X, Wilson MW, Liu K, Lee P, Yeomans L, Hagen SE, Lin CM, Wen B, Sun D, White AD, Showalter HD, Antonetti DA. Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema. Bioorganic & Medicinal Chemistry. 115480. PMID 32327351 DOI: 10.1016/J.Bmc.2020.115480  0.315
2018 Beyett TS, Gan X, Reilly SM, Gomez AV, Chang L, Tesmer JJG, Saltiel AR, Showalter HD. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity. Bioorganic & Medicinal Chemistry. PMID 30270002 DOI: 10.1016/J.Bmc.2018.09.020  0.309
2018 Madak JT, Cuthbertson CR, Miyata Y, Tamura S, Petrunak EM, Stuckey JA, Han Y, He M, Sun D, Showalter HD, Neamati N. Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase. Journal of Medicinal Chemistry. PMID 29727569 DOI: 10.1021/Acs.Jmedchem.7B01862  0.314
2018 Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJG. Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition. Molecular Pharmacology. 94: 1210-1219. DOI: 10.2210/Pdb6Boe/Pdb  0.311
2017 Jin Y, Huang X, Papke RL, Jutkiewicz EM, Showalter HD, Zhan CG. Design, synthesis, and biological activity of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry Letters. PMID 28838693 DOI: 10.1016/J.Bmcl.2017.08.025  0.366
2017 Madak JT, Cuthbertson CR, Chen W, Showalter HD, Neamati N. Design, synthesis, and characterization of brequinar conjugates as probes to study DHODH inhibition. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28833638 DOI: 10.1002/Chem.201702999  0.308
2016 Carpenter C, Sorenson RJ, Jin Y, Klossowski S, Cierpicki T, Gnegy M, Showalter HD. Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C. Bioorganic & Medicinal Chemistry. PMID 27647375 DOI: 10.1016/J.Bmc.2016.09.002  0.38
2016 Passalacqua KD, Charbonneau ME, Donato NJ, Showalter HD, Sun D, Wen B, He M, Sun H, O'Riordan MX, Wobus CE. Anti-infective activity of 2-cyano-3-acrylamide inhibitors with improved drug-like properties against two intracellular pathogens. Antimicrobial Agents and Chemotherapy. PMID 27139470 DOI: 10.1128/Aac.03021-15  0.322
2015 Xu H, Majmudar JD, Davda D, Ghanakota P, Kim KH, Carlson HA, Showalter HD, Martin BR, Amidon GL. Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes. Molecular Pharmaceutics. 12: 3399-407. PMID 26262434 DOI: 10.1021/Acs.Molpharmaceut.5B00414  0.327
2015 Gibbons GS, Showalter HD, Nikolovska-Coleska Z. Novel carboxaldehyde mediated synthetic pathway for 5'-amino adenosine analogues. Nucleosides, Nucleotides & Nucleic Acids. 34: 348-60. PMID 25874943 DOI: 10.1080/15257770.2014.1001074  0.329
2015 Peterson LF, Sun H, Liu Y, Potu H, Kandarpa M, Ermann M, Courtney SM, Young M, Showalter HD, Sun D, Jakubowiak A, Malek SN, Talpaz M, Donato NJ. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. Blood. 125: 3588-97. PMID 25814533 DOI: 10.1182/Blood-2014-10-605584  0.323
2015 Winters T, Sercel A, Suto C, Elliott W, Leopold W, Leopold J, Showalter H. Design and synthesis of 2-nitroimidazoles with variable alkylating and acylating functionality. Chemical & Pharmaceutical Bulletin. 62: 301-3. PMID 24583786 DOI: 10.1248/Cpb.C13-00903  0.344
2014 Charbonneau ME, Gonzalez-Hernandez MJ, Showalter HD, Donato NJ, Wobus CE, O'Riordan MX. Small molecule deubiquitinase inhibitors promote macrophage anti-infective capacity. Plos One. 9: e104096. PMID 25093325 DOI: 10.1371/Journal.Pone.0104096  0.335
2014 Gonzalez-Hernandez MJ, Pal A, Gyan KE, Charbonneau ME, Showalter HD, Donato NJ, O'Riordan M, Wobus CE. Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses. Plos One. 9: e94491. PMID 24722666 DOI: 10.1371/Journal.Pone.0094491  0.341
2014 Peng Z, Maxwell DS, Sun D, Bhanu Prasad BA, Schuber PT, Pal A, Ying Y, Han D, Gao L, Wang S, Levitzki A, Kapuria V, Talpaz M, Young M, Showalter HD, et al. Degrasyn-like symmetrical compounds: possible therapeutic agents for multiple myeloma (MM-I). Bioorganic & Medicinal Chemistry. 22: 1450-8. PMID 24457091 DOI: 10.1016/J.Bmc.2013.12.048  0.326
2014 Abulwerdi FA, Mady ASA, Perdih A, Stuckey JA, Showalter HD, Nikolovska-Coleska Z. Abstract 1641: Structure-based design and development of pyrazolopyridine-based inhibitors of Mcl-1 Cancer Research. 74: 1641-1641. DOI: 10.1158/1538-7445.Am2014-1641  0.348
2013 Zeller J, Turbiak AJ, Powelson IA, Lee S, Sun D, Showalter HD, Fearon ER. Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of β-catenin/TCF transcription. Bioorganic & Medicinal Chemistry Letters. 23: 5814-20. PMID 24060489 DOI: 10.1016/J.Bmcl.2013.08.111  0.671
2012 Brooks AF, Vélez-Martínez CS, Showalter HD, Garcia GA. Investigating the prevalence of queuine in Escherichia coli RNA via incorporation of the tritium-labeled precursor, preQ(1). Biochemical and Biophysical Research Communications. 425: 83-8. PMID 22819844 DOI: 10.1016/J.Bbrc.2012.07.055  0.524
2012 Gill SK, Xu H, Kirchhoff PD, Cierpicki T, Turbiak AJ, Wan B, Zhang N, Peng KW, Franzblau SG, Garcia GA, Showalter HD. Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases. Journal of Medicinal Chemistry. 55: 3814-26. PMID 22452568 DOI: 10.1021/Jm201716N  0.687
2012 Peterson LF, Sun H, Liu Y, Kandarpa M, Giannola D, Mercer J, Showalter HD, Jakubowiak A, Talpaz M, Donato NJ. Usp9x Silencing and Enzyme Inhibition Suppress Myeloma Cell Survival and in Vivo Tumor Growth. Blood. 120: 2936-2936. DOI: 10.1182/Blood.V120.21.2936.2936  0.306
2012 Bajwa N, Abulwerdi F, Liao C, Mady A, Bernardo JD, Azmi A, Cierpicki T, Stuckey J, Showalter H, Mohammad R, Nikolovska-Coleska Z. Abstract 2917: Design, synthesis and biological evaluation of two chemical classes as novel small molecule Mcl-1 inhibitors Cancer Research. 72: 2917-2917. DOI: 10.1158/1538-7445.Am2012-2917  0.349
2011 Kapuria V, Levitzki A, Bornmann WG, Maxwell D, Priebe W, Sorenson RJ, Showalter HD, Talpaz M, Donato NJ. A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination Cellular Signalling. 23: 2076-2085. PMID 21855629 DOI: 10.1016/J.Cellsig.2011.08.002  0.309
2011 Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, et al. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. Journal of Biomolecular Screening. 16: 825-35. PMID 21844328 DOI: 10.1177/1087057111414893  0.317
2011 Okawada M, Koga H, Larsen SD, Showalter HD, Turbiak AJ, Jin X, Lucas PC, Lipka E, Hillfinger J, Kim JS, Teitelbaum DH. Use of enterally delivered angiotensin II type Ia receptor antagonists to reduce the severity of colitis. Digestive Diseases and Sciences. 56: 2553-65. PMID 21399927 DOI: 10.1007/S10620-011-1651-9  0.661
2011 Chen YC, Brooks AF, Goodenough-Lashua DM, Kittendorf JD, Showalter HD, Garcia GA. Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases. Nucleic Acids Research. 39: 2834-44. PMID 21131277 DOI: 10.1093/Nar/Gkq1188  0.573
2011 Peterson LF, Sun H, Young M, Showalter HD, Jakubowiak AJ, Talpaz M, Donato N. Mechanism of Action of a Small Molecule Inhibitor That Targets Usp9x Deubiquitinase Activity in Multiple Myeloma and Mantle Cell Lymphoma Blood. 118: 1415-1415. DOI: 10.1182/Blood.V118.21.1415.1415  0.365
2009 Turbiak AJ, Showalter HD. A novel synthesis of N(1)-(substituted)-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones. Tetrahedron Letters. 50: 1996-1997. PMID 21643441 DOI: 10.1016/J.Tetlet.2009.02.084  0.663
2009 Okawada M, Koga H, Larsen SD, Showalter HD, Lucas PC, Teitelbaum DH. 243 Use of Enterally-Delivered Angiotensin II Type IA Receptor Antagonists to Reduce the Severity of Colitis Gastroenterology. 136. DOI: 10.1016/S0016-5085(09)60214-6  0.333
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