| Year |
Citation |
Score |
| 2022 |
Mengaziol J, Dunn AD, Salimando G, Wooldridge L, Crues-Muncunill J, Eacret D, Chen C, Bland K, Liu-Chen LY, Ehrlich ME, Corder G, Blendy JA. A novel Oprm1-Cre mouse maintains endogenous expression, function and enables detailed molecular characterization of μ-opioid receptor cells. Plos One. 17: e0270317. PMID 36534642 DOI: 10.1371/journal.pone.0270317 |
0.451 |
|
| 2022 |
Liu-Chen LY, Huang P. Signaling underlying kappa opioid receptor-mediated behaviors in rodents. Frontiers in Neuroscience. 16: 964724. PMID 36408401 DOI: 10.3389/fnins.2022.964724 |
0.395 |
|
| 2022 |
Chen C, Huang P, Bland K, Li M, Zhang Y, Liu-Chen LY. Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion. Frontiers in Pharmacology. 13: 835809. PMID 35652052 DOI: 10.3389/fphar.2022.835809 |
0.445 |
|
| 2022 |
Reichenbach ZW, DiMattio K, Rajakaruna S, Ambrose D, Cornwell WD, Tallarida RJ, Rogers T, Liu-Chen LY, Tuma RF, Ward SJ. Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966. Frontiers in Pharmacology. 13: 803331. PMID 35529434 DOI: 10.3389/fphar.2022.803331 |
0.458 |
|
| 2022 |
Huang P, Chen C, Cao D, Huang M, Liu-Chen LY. Agonist-promoted kappa opioid receptor (KOR) phosphorylation has behavioral endpoint-dependent and sex-specific effects. Neuropharmacology. 202: 108860. PMID 34736959 DOI: 10.1016/j.neuropharm.2021.108860 |
0.314 |
|
| 2021 |
Cahill C, Tejeda HA, Spetea M, Chen C, Liu-Chen LY. Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and Function. Handbook of Experimental Pharmacology. PMID 33754230 DOI: 10.1007/164_2021_433 |
0.43 |
|
| 2021 |
Huang B, Gunta R, Wang H, Li M, Cao D, Mendez RE, Gillespie JC, Chen C, Huang LM, Liu-Chen LY, Selley DE, Zhang Y. Verifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(4'-pyridyl) carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors. Bioorganic Chemistry. 109: 104702. PMID 33631465 DOI: 10.1016/j.bioorg.2021.104702 |
0.435 |
|
| 2021 |
Wang H, Cao D, Gillespie JC, Mendez RE, Selley DE, Liu-Chen LY, Zhang Y. Exploring the putative mechanism of allosteric modulations by mixed-action kappa/mu opioid receptor bitopic modulators. Future Medicinal Chemistry. PMID 33590767 DOI: 10.4155/fmc-2020-0308 |
0.433 |
|
| 2020 |
Liu JJ, Chiu YT, Chen C, Huang P, Mann M, Liu-Chen LY. Pharmacological and phosphoproteomic approaches to roles of protein kinase C in kappa opioid receptor-mediated effects in mice. Neuropharmacology. 108324. PMID 32976891 DOI: 10.1016/j.neuropharm.2020.108324 |
0.423 |
|
| 2020 |
Cao D, Huang P, Chiu YT, Chen C, Wang H, Li M, Zheng Y, Ehlert FJ, Zhang Y, Liu-Chen LY. Comparison of Pharmacological Properties between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect between Agonist Bias and Pharmacological Effects. Acs Chemical Neuroscience. PMID 32897695 DOI: 10.1021/acschemneuro.0c00407 |
0.517 |
|
| 2020 |
Huang P, Gentile TA, Muschamp JW, Liu-Chen LY. The kappa opioid receptor agonist U50,488H did not affect brain-stimulation reward while it elicited conditioned place aversion in mice. Bmc Research Notes. 13: 384. PMID 32799930 DOI: 10.1186/s13104-020-05227-7 |
0.497 |
|
| 2020 |
Chen C, Willhouse AH, Huang P, Ko N, Wang Y, Xu B, Huang LHM, Kieffer B, Barbe MF, Liu-Chen LY. Characterization of a Knockin Mouse Line Expressing a Fusion Protein of Kappa Opioid Receptor Conjugated with tdTomato: 3-Dimensional Brain Imaging Via CLARITY. Eneuro. PMID 32561573 DOI: 10.1523/ENEURO.0028-20.2020 |
0.331 |
|
| 2019 |
Zheng Y, Obeng S, Reinecke BA, Chen C, Phansalkar PS, Walentiny DM, Gerk PM, Liu-Chen LY, Selley DE, Beardsley PM, Zhang Y. Pharmacological characterization of 17-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-6-[(3'-fluoro-4'-pyridyl)acetamido]morphinan (NFP) as a dual selective MOR/KOR ligand with potential applications in treating opioid use disorder. European Journal of Pharmacology. 172812. PMID 31743739 DOI: 10.1016/J.Ejphar.2019.172812 |
0.511 |
|
| 2019 |
Obeng S, Jali A, Zheng Y, Wang H, Schwienteck K, Chen C, Stevens DL, Akbarali H, Dewey WL, Banks ML, Liu-Chen LY, Selley DE, Zhang Y. Characterization of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(indole-7-carboxamido)morphinan (NAN) as a Novel Opioid Receptor Modulator for Opioid Use Disorder Treatment. Acs Chemical Neuroscience. PMID 30758946 DOI: 10.1021/Acschemneuro.9B00038 |
0.549 |
|
| 2019 |
Borsodi A, Bruchas M, Caló G, Chavkin C, Christie MJ, Civelli O, Connor M, Cox BM, Devi LA, Evans C, Höllt V, Henderson G, Husbands S, Kelly E, Kieffer B, ... ... Liu-Chen L, et al. Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f50/2019.4 |
0.486 |
|
| 2018 |
Liu JJ, Chiu YT, DiMattio KM, Chen C, Huang P, Gentile TA, Muschamp JW, Cowan A, Mann M, Liu-Chen LY. Phosphoproteomic approach for agonist-specific signaling in mouse brains: mTOR pathway is involved in κ opioid aversion. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30082888 DOI: 10.1038/S41386-018-0155-0 |
0.466 |
|
| 2018 |
Liu JJ, Sharma K, Zangrandi L, Chen C, Humphrey SJ, Chiu YT, Spetea M, Liu-Chen LY, Schwarzer C, Mann M. In vivo brain GPCR signaling elucidated by phosphoproteomics. Science (New York, N.Y.). 360. PMID 29930108 DOI: 10.1126/Science.Aao4927 |
0.446 |
|
| 2018 |
Hicks C, Huang P, Ramos L, Nayak SU, Caro Y, Reitz AB, Smith GR, Lee DY, Rawls SM, Liu-Chen LY. Dopamine D1-like receptor agonist and D2-like receptor antagonist (-)-Stepholidine reduces reinstatement of drug-seeking behavior for 3,4-methylenedioxypyrovalerone (MDPV) in rats. Acs Chemical Neuroscience. PMID 29597343 DOI: 10.1021/Acschemneuro.7B00510 |
0.417 |
|
| 2017 |
Chiu YT, Chen C, Yu D, Schulz S, Liu-Chen LY. Agonist-dependent and -independent kappa opioid receptor phosphorylation showed distinct phosphorylation patterns and resulted in different cellular outcomes. Molecular Pharmacology. PMID 28893975 DOI: 10.1124/Mol.117.108555 |
0.323 |
|
| 2017 |
Lee DY, Liu J, Zhang S, Huang P, Liu-Chen LY. Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. Bioorganic & Medicinal Chemistry Letters. PMID 28214075 DOI: 10.1016/j.bmcl.2017.01.090 |
0.365 |
|
| 2017 |
Xu W, Wang X, Tocker AM, Huang P, Reith ME, Liu-Chen LY, Smith AB, Kortagere S. Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists. Acs Chemical Neuroscience. 8: 486-500. PMID 27801563 DOI: 10.1021/Acschemneuro.6B00221 |
0.457 |
|
| 2016 |
Wang XF, Barbier E, Chiu YT, He Y, Zhan J, Bi GH, Zhang HY, Feng B, Liu-Chen LY, Wang JB, Xi ZX. T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10392-10403. PMID 27707973 DOI: 10.1523/JNEUROSCI.0603-16.2016 |
0.432 |
|
| 2016 |
Huang P, Tunis J, Parry C, Tallarida R, Liu-Chen LY. Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test. European Journal of Pharmacology. PMID 27044434 DOI: 10.1016/j.ejphar.2016.03.061 |
0.479 |
|
| 2016 |
Huang P, Yakovleva T, Aldrich JV, Tunis J, Parry C, Liu-Chen LY. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neuroscience Letters. PMID 26780565 DOI: 10.1016/J.Neulet.2016.01.017 |
0.419 |
|
| 2015 |
Chen C, Chiu YT, Wu W, Huang P, Mann A, Schulz S, Liu-Chen LY. Determination of sites of U50,488H-promoted phosphorylation of the mouse kappa opioid receptor (KOPR): Disconnect between KOPR phosphorylation and internalization. The Biochemical Journal. PMID 26635353 DOI: 10.1042/Bj20141471 |
0.397 |
|
| 2015 |
Lee DY, Deng G, Ma Z, Xu W, Yang L, Liu J, Dai R, Liu-Chen LY. Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ-opioid receptor agonists. Bioorganic & Medicinal Chemistry Letters. PMID 26330078 DOI: 10.1016/j.bmcl.2015.06.092 |
0.56 |
|
| 2015 |
DiMattio KM, Ehlert FJ, Liu-Chen LY. Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors. European Journal of Pharmacology. 761: 235-44. PMID 26057692 DOI: 10.1016/j.ejphar.2015.05.054 |
0.525 |
|
| 2015 |
DiMattio KM, Chen C, Shi L, Liu-Chen LY. K303⁶·⁵⁸ in the μ opioid (MOP) receptor is important in conferring selectivity for covalent binding of β-funaltrexamine (β-FNA). European Journal of Pharmacology. 748: 93-100. PMID 25481857 DOI: 10.1016/j.ejphar.2014.11.028 |
0.455 |
|
| 2015 |
Huang P, Chen C, Liu-Chen LY. Detection of mu opioid receptor (MOPR) and its glycosylation in rat and mouse brains by western blot with anti-μC, an affinity-purified polyclonal anti-MOPR antibody. Methods in Molecular Biology (Clifton, N.J.). 1230: 141-54. PMID 25293322 DOI: 10.1007/978-1-4939-1708-2_11 |
0.362 |
|
| 2015 |
Chen C, Huang P, Liu-Chen LY. Identification and verification of proteins interacting with the kappa opioid receptor (KOPR). Methods in Molecular Biology (Clifton, N.J.). 1230: 129-40. PMID 25293321 DOI: 10.1007/978-1-4939-1708-2_10 |
0.5 |
|
| 2014 |
Dimattio KM, Yakovleva TV, Aldrich JV, Cowan A, Liu-Chen LY. Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice. Neuroscience Letters. 563: 155-9. PMID 24503508 DOI: 10.1016/J.Neulet.2014.01.022 |
0.464 |
|
| 2014 |
Wang YJ, Huang P, Blendy JA, Liu-Chen LY. Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPγS binding in mice with Oprm1 A112G. Addiction Biology. 19: 354-61. PMID 22862850 DOI: 10.1111/j.1369-1600.2012.00484.x |
0.374 |
|
| 2013 |
Munro TA, Xu W, Ho DM, Liu-Chen LY, Cohen BM. Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity. Beilstein Journal of Organic Chemistry. 9: 2916-24. PMID 24454571 DOI: 10.3762/Bjoc.9.328 |
0.509 |
|
| 2013 |
Xu W, Wang Y, Ma Z, Chiu YT, Huang P, Rasakham K, Unterwald E, Lee DY, Liu-Chen LY. L-isocorypalmine reduces behavioral sensitization and rewarding effects of cocaine in mice by acting on dopamine receptors. Drug and Alcohol Dependence. 133: 693-703. PMID 24080315 DOI: 10.1016/j.drugalcdep.2013.08.021 |
0.325 |
|
| 2013 |
Huang P, Chiu YT, Chen C, Wang Y, Liu-Chen LY. A G protein-coupled receptor (GPCR) in red: live cell imaging of the kappa opioid receptor-tdTomato fusion protein (KOPR-tdT) in neuronal cells. Journal of Pharmacological and Toxicological Methods. 68: 340-5. PMID 23856011 DOI: 10.1016/j.vascn.2013.07.002 |
0.393 |
|
| 2013 |
Xu W, Chen C, Li JG, Dimattio K, Wang Y, Unterwald E, Liu-Chen LY. PKA and ERK1/2 are involved in dopamine D₁ receptor-induced heterologous desensitization of the δ opioid receptor. Life Sciences. 92: 1101-9. PMID 23624231 DOI: 10.1016/j.lfs.2013.04.006 |
0.539 |
|
| 2012 |
Schattauer SS, Miyatake M, Shankar H, Zietz C, Levin JR, Liu-Chen LY, Gurevich VV, Rieder MJ, Chavkin C. Ligand directed signaling differences between rodent and human κ-opioid receptors. The Journal of Biological Chemistry. 287: 41595-607. PMID 23086943 DOI: 10.1074/Jbc.M112.381368 |
0.333 |
|
| 2012 |
Li JG, Chen C, Huang P, Wang Y, Liu-Chen LY. 14-3-3ζ Protein regulates anterograde transport of the human κ-opioid receptor (hKOPR). The Journal of Biological Chemistry. 287: 37778-92. PMID 22989890 DOI: 10.1074/jbc.M112.359679 |
0.41 |
|
| 2012 |
Rasakham K, McGillivray KL, Liu-Chen LY. Sex differences in U50,488H-induced phosphorylation of p44/42 mitogen-activated protein kinase in the guinea pig brain. Neuroscience. 223: 447-56. PMID 22863678 DOI: 10.1016/j.neuroscience.2012.07.040 |
0.398 |
|
| 2012 |
Rives ML, Rossillo M, Liu-Chen LY, Javitch JA. 6'-Guanidinonaltrindole (6'-GNTI) is a G protein-biased κ-opioid receptor agonist that inhibits arrestin recruitment. The Journal of Biological Chemistry. 287: 27050-4. PMID 22736766 DOI: 10.1074/Jbc.C112.387332 |
0.579 |
|
| 2012 |
Lisek R, Xu W, Yuvasheva E, Chiu YT, Reitz AB, Liu-Chen LY, Rawls SM. Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation. Drug and Alcohol Dependence. 126: 257-62. PMID 22652295 DOI: 10.1016/J.Drugalcdep.2012.04.021 |
0.352 |
|
| 2012 |
Wang YJ, Huang P, Ung A, Blendy JA, Liu-Chen LY. Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G. Neuroscience. 205: 178-84. PMID 22240251 DOI: 10.1016/j.neuroscience.2011.12.033 |
0.311 |
|
| 2012 |
Béguin C, Potuzak J, Xu W, Liu-Chen LY, Streicher JM, Groer CE, Bohn LM, Carlezon WA, Cohen BM. Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues. Bioorganic & Medicinal Chemistry Letters. 22: 1023-6. PMID 22204910 DOI: 10.1016/J.Bmcl.2011.11.128 |
0.538 |
|
| 2012 |
Huang P, Chen C, Mague SD, Blendy JA, Liu-Chen LY. A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability. The Biochemical Journal. 441: 379-86. PMID 21864297 DOI: 10.1042/Bj20111050 |
0.356 |
|
| 2011 |
Wang YJ, Rasakham K, Huang P, Chudnovskaya D, Cowan A, Liu-Chen LY. Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig. The Journal of Pharmacology and Experimental Therapeutics. 339: 438-50. PMID 21841040 DOI: 10.1124/Jpet.111.183905 |
0.414 |
|
| 2011 |
Zhu J, Spencer TJ, Liu-Chen LY, Biederman J, Bhide PG. Methylphenidate and μ opioid receptor interactions: a pharmacological target for prevention of stimulant abuse. Neuropharmacology. 61: 283-92. PMID 21545805 DOI: 10.1016/j.neuropharm.2011.04.015 |
0.451 |
|
| 2011 |
Chen C, Wang Y, Huang P, Liu-Chen LY. Effects of C-terminal modifications of GEC1 protein and gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein (GABARAP), two microtubule-associated proteins, on kappa opioid receptor expression. The Journal of Biological Chemistry. 286: 15106-15. PMID 21388957 DOI: 10.1074/jbc.M111.230896 |
0.427 |
|
| 2011 |
Rasakham K, Liu-Chen LY. Sex differences in kappa opioid pharmacology. Life Sciences. 88: 2-16. PMID 20951148 DOI: 10.1016/j.lfs.2010.10.007 |
0.422 |
|
| 2010 |
Lee DY, Yang L, Xu W, Deng G, Guo L, Liu-Chen LY. Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A. Bioorganic & Medicinal Chemistry Letters. 20: 5749-52. PMID 20801035 DOI: 10.1016/j.bmcl.2010.08.001 |
0.46 |
|
| 2010 |
Huang P, Liu-Chen LY, Kirby LG. Anxiety-like effects of SR141716-precipitated delta9-tetrahydrocannabinol withdrawal in mice in the elevated plus-maze. Neuroscience Letters. 475: 165-8. PMID 20363293 DOI: 10.1016/j.neulet.2010.03.071 |
0.312 |
|
| 2010 |
Woodruff-Pak DS, Lehr MA, Li JG, Liu-Chen LY. Young and older good learners have higher levels of brain nicotinic receptor binding. Neurobiology of Aging. 31: 1032-43. PMID 18950900 DOI: 10.1016/j.neurobiolaging.2008.09.002 |
0.309 |
|
| 2010 |
Ma Z, Deng G, Dai R, Xu W, Liu-Chen LY, Lee DYW. Thermal degradation products derived from the smoke of Salvia divinorum leaves Tetrahedron Letters. 51: 5480-5482. DOI: 10.1016/j.tetlet.2010.08.033 |
0.43 |
|
| 2010 |
Huang P, Liu-Chen LY. The brain dynorphins/kappa opioid receptor (DYN/KOPR) system plays a role in anxiety regulation Journal of Medical Sciences. 30: 135-139. |
0.406 |
|
| 2009 |
Huang P, Liu-Chen LY, Unterwald EM, Cowan A. Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 mice. Neuroscience Letters. 465: 66-70. PMID 19733208 DOI: 10.1016/J.Neulet.2009.08.073 |
0.329 |
|
| 2009 |
Mague SD, Isiegas C, Huang P, Liu-Chen LY, Lerman C, Blendy JA. Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. Proceedings of the National Academy of Sciences of the United States of America. 106: 10847-52. PMID 19528658 DOI: 10.1073/Pnas.0901800106 |
0.409 |
|
| 2009 |
Huang P, Liu-Chen LY. Detecting the mu opioid receptor in brain following SDS-PAGE with multiple approaches. Frontiers in Bioscience (Elite Edition). 1: 220-7. PMID 19482639 |
0.411 |
|
| 2009 |
Wang Q, Liu-Chen LY, Traynor JR. Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells. The Journal of Biological Chemistry. 284: 18357-67. PMID 19416973 DOI: 10.1074/jbc.M109.015453 |
0.519 |
|
| 2009 |
Chen Y, Liu-Chen LY. Chaperone-like effects of cell-permeant ligands on opioid receptors. Frontiers in Bioscience (Landmark Edition). 14: 634-43. PMID 19273091 DOI: 10.2741/3269 |
0.534 |
|
| 2009 |
Yang L, Xu W, Chen F, Liu-Chen LY, Ma Z, Lee DY. Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A. Bioorganic & Medicinal Chemistry Letters. 19: 1301-4. PMID 19211245 DOI: 10.1016/j.bmcl.2009.01.078 |
0.548 |
|
| 2009 |
Béguin C, Duncan KK, Munro TA, Ho DM, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor. Bioorganic & Medicinal Chemistry. 17: 1370-80. PMID 19147366 DOI: 10.1016/J.Bmc.2008.12.012 |
0.524 |
|
| 2009 |
Chen Y, Chen C, Kotsikorou E, Lynch DL, Reggio PH, Liu-Chen LY. GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect. The Journal of Biological Chemistry. 284: 1673-85. PMID 19001416 DOI: 10.1074/jbc.M808303200 |
0.548 |
|
| 2009 |
Inan S, Lee DY, Liu-Chen LY, Cowan A. Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A. Naunyn-Schmiedeberg's Archives of Pharmacology. 379: 263-70. PMID 18925386 DOI: 10.1007/S00210-008-0358-8 |
0.387 |
|
| 2008 |
Wang Y, Van Bockstaele EJ, Liu-Chen LY. In vivo trafficking of endogenous opioid receptors. Life Sciences. 83: 693-9. PMID 18930741 DOI: 10.1016/j.lfs.2008.09.023 |
0.575 |
|
| 2008 |
Li JG, Lehr M, Liu-Chen LY, Woodruff-Pak DS. Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbits. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2820-30. PMID 18256594 DOI: 10.1038/npp.2008.1 |
0.321 |
|
| 2008 |
Li JG, Haines DS, Liu-Chen LY. Agonist-promoted Lys63-linked polyubiquitination of the human kappa-opioid receptor is involved in receptor down-regulation. Molecular Pharmacology. 73: 1319-30. PMID 18212250 DOI: 10.1124/mol.107.042846 |
0.561 |
|
| 2008 |
Ma Z, Xu W, Liu-Chen LY, Lee DY. Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. Bioorganic & Medicinal Chemistry. 16: 3218-23. PMID 18166466 DOI: 10.1016/j.bmc.2007.12.021 |
0.534 |
|
| 2008 |
Wang Y, Chen Y, Xu W, Lee DY, Ma Z, Rawls SM, Cowan A, Liu-Chen LY. 2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A. The Journal of Pharmacology and Experimental Therapeutics. 324: 1073-83. PMID 18089845 DOI: 10.1124/Jpet.107.132142 |
0.55 |
|
| 2008 |
Munro TA, Duncan KK, Xu W, Wang Y, Liu-Chen LY, Carlezon WA, Cohen BM, Béguin C. Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorganic & Medicinal Chemistry. 16: 1279-86. PMID 17981041 DOI: 10.1016/J.Bmc.2007.10.067 |
0.463 |
|
| 2008 |
Huang P, Chen C, Xu W, Yoon SI, Unterwald EM, Pintar JE, Wang Y, Chong PL, Liu-Chen LY. Brain region-specific N-glycosylation and lipid rafts association of the rat mu opioid receptor. Biochemical and Biophysical Research Communications. 365: 82-8. PMID 17980152 DOI: 10.1016/J.Bbrc.2007.10.128 |
0.443 |
|
| 2008 |
Béguin C, Potter DN, Dinieri JA, Munro TA, Richards MR, Paine TA, Berry L, Zhao Z, Roth BL, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy. The Journal of Pharmacology and Experimental Therapeutics. 324: 188-95. PMID 17951511 DOI: 10.1124/Jpet.107.129023 |
0.445 |
|
| 2007 |
Huang P, Xu W, Yoon SI, Chen C, Chong PL, Unterwald EM, Liu-Chen LY. Agonist treatment did not affect association of mu opioid receptors with lipid rafts and cholesterol reduction had opposite effects on the receptor-mediated signaling in rat brain and CHO cells. Brain Research. 1184: 46-56. PMID 17980352 DOI: 10.1016/J.Brainres.2007.09.096 |
0.48 |
|
| 2007 |
Li JG, Chen C, Liu-Chen LY. N-Glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway. Biochemistry. 46: 10960-70. PMID 17711303 DOI: 10.1021/bi700443j |
0.397 |
|
| 2007 |
Xie Z, Li Z, Guo L, Ye C, Li J, Yu X, Yang H, Wang Y, Chen C, Zhang D, Liu-Chen LY. Regulator of G protein signaling proteins differentially modulate signaling of mu and delta opioid receptors. European Journal of Pharmacology. 565: 45-53. PMID 17433292 DOI: 10.1016/j.ejphar.2007.03.005 |
0.56 |
|
| 2007 |
Chen Y, Chen C, Liu-Chen LY. Dynorphin peptides differentially regulate the human kappa opioid receptor. Life Sciences. 80: 1439-48. PMID 17316701 DOI: 10.1016/j.lfs.2007.01.018 |
0.549 |
|
| 2007 |
Munro TA, Duncan KK, Staples RJ, Xu W, Liu-Chen LY, Béguin C, Carlezon WA, Cohen BM. 8-epi-Salvinorin B: crystal structure and affinity at the kappa opioid receptor. Beilstein Journal of Organic Chemistry. 3: 1. PMID 17212822 DOI: 10.1186/1860-5397-3-1 |
0.43 |
|
| 2007 |
Huang P, Xu W, Yoon SI, Chen C, Chong PL, Liu-Chen LY. Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells. Biochemical Pharmacology. 73: 534-49. PMID 17141202 DOI: 10.1016/J.Bcp.2006.10.032 |
0.472 |
|
| 2006 |
Lee DY, He M, Liu-Chen LY, Wang Y, Li JG, Xu W, Ma Z, Carlezon WA, Cohen B. Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues. Bioorganic & Medicinal Chemistry Letters. 16: 5498-502. PMID 16945525 DOI: 10.1016/j.bmcl.2006.08.051 |
0.454 |
|
| 2006 |
Chen Y, Chen C, Wang Y, Liu-Chen LY. Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists. The Journal of Pharmacology and Experimental Therapeutics. 319: 765-75. PMID 16882876 DOI: 10.1124/jpet.106.107987 |
0.62 |
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| 2006 |
Béguin C, Richards MR, Li JG, Wang Y, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18). Bioorganic & Medicinal Chemistry Letters. 16: 4679-85. PMID 16777411 DOI: 10.1016/J.Bmcl.2006.05.093 |
0.529 |
|
| 2006 |
Wang Y, Dun SL, Huang P, Chen C, Chen Y, Unterwald EM, Dun NJ, Van Bockstaele EJ, Liu-Chen LY. Distribution and ultrastructural localization of GEC1 in the rat CNS. Neuroscience. 140: 1265-76. PMID 16650615 DOI: 10.1016/J.Neuroscience.2006.03.013 |
0.363 |
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| 2006 |
Feng P, Rahim RT, Cowan A, Liu-Chen LY, Peng X, Gaughan J, Meissler JJ, Adler MW, Eisenstein TK. Effects of mu, kappa or delta opioids administered by pellet or pump on oral Salmonella infection and gastrointestinal transit. European Journal of Pharmacology. 534: 250-7. PMID 16513108 DOI: 10.1016/J.Ejphar.2006.01.048 |
0.508 |
|
| 2006 |
Xu W, Yoon SI, Huang P, Wang Y, Chen C, Chong PL, Liu-Chen LY. Localization of the kappa opioid receptor in lipid rafts. The Journal of Pharmacology and Experimental Therapeutics. 317: 1295-306. PMID 16505160 DOI: 10.1124/Jpet.105.099507 |
0.394 |
|
| 2006 |
Weinman EJ, Hall RA, Friedman PA, Liu-Chen LY, Shenolikar S. The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases. Annual Review of Physiology. 68: 491-505. PMID 16460281 DOI: 10.1146/Annurev.Physiol.68.040104.131050 |
0.356 |
|
| 2006 |
Chen C, Li JG, Chen Y, Huang P, Wang Y, Liu-Chen LY. GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor. The Journal of Biological Chemistry. 281: 7983-93. PMID 16431922 DOI: 10.1074/jbc.M509805200 |
0.594 |
|
| 2005 |
Xu W, Campillo M, Pardo L, Kim de Riel J, Liu-Chen LY. The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions. Biochemistry. 44: 16014-25. PMID 16331961 DOI: 10.1021/bi050938a |
0.487 |
|
| 2005 |
Tanaka S, Fan LW, Tien LT, Park Y, Liu-Chen LY, Rockhold RW, Ho IK. Butorphanol dependence increases hippocampal kappa-opioid receptor gene expression. Journal of Neuroscience Research. 82: 255-63. PMID 16130146 DOI: 10.1002/Jnr.20620 |
0.557 |
|
| 2005 |
Lee DY, Ma Z, Liu-Chen LY, Wang Y, Chen Y, Carlezon WA, Cohen B. New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human kappa opioid receptors. Bioorganic & Medicinal Chemistry. 13: 5635-9. PMID 16084728 DOI: 10.1016/J.Bmc.2005.05.054 |
0.52 |
|
| 2005 |
Lee DY, He M, Kondaveti L, Liu-Chen LY, Ma Z, Wang Y, Chen Y, Li JG, Beguin C, Carlezon WA, Cohen B. Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues. Bioorganic & Medicinal Chemistry Letters. 15: 4169-73. PMID 16051487 DOI: 10.1016/j.bmcl.2005.06.092 |
0.556 |
|
| 2005 |
Lee DY, Karnati VV, He M, Liu-Chen LY, Kondaveti L, Ma Z, Wang Y, Chen Y, Beguin C, Carlezon WA, Cohen B. Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues. Bioorganic & Medicinal Chemistry Letters. 15: 3744-7. PMID 15993589 DOI: 10.1016/J.Bmcl.2005.05.048 |
0.607 |
|
| 2005 |
Béguin C, Richards MR, Wang Y, Chen Y, Liu-Chen LY, Ma Z, Lee DY, Carlezon WA, Cohen BM. Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2). Bioorganic & Medicinal Chemistry Letters. 15: 2761-5. PMID 15869877 DOI: 10.1016/J.Bmcl.2005.03.113 |
0.602 |
|
| 2005 |
Wang Y, Tang K, Inan S, Siebert D, Holzgrabe U, Lee DY, Huang P, Li JG, Cowan A, Liu-Chen LY. Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo. The Journal of Pharmacology and Experimental Therapeutics. 312: 220-30. PMID 15383632 DOI: 10.1124/Jpet.104.073668 |
0.603 |
|
| 2004 |
Liu-Chen LY. Agonist-induced regulation and trafficking of kappa opioid receptors. Life Sciences. 75: 511-36. PMID 15158363 DOI: 10.1016/j.lfs.2003.10.041 |
0.589 |
|
| 2004 |
Huang P, Steplock D, Weinman EJ, Hall RA, Ding Z, Li J, Wang Y, Liu-Chen LY. kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins. The Journal of Biological Chemistry. 279: 25002-9. PMID 15070904 DOI: 10.1074/Jbc.M313366200 |
0.463 |
|
| 2004 |
Chen C, Li J, Bot G, Szabo I, Rogers TJ, Liu-Chen LY. Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor. European Journal of Pharmacology. 483: 175-86. PMID 14729105 DOI: 10.1016/j.ejphar.2003.10.033 |
0.592 |
|
| 2003 |
Wang Y, Li JG, Huang P, Xu W, Liu-Chen LY. Differential effects of agonists on adenylyl cyclase superactivation mediated by the kappa opioid receptors: adenylyl cyclase superactivation is independent of agonist-induced phosphorylation, desensitization, internalization, and down-regulation. The Journal of Pharmacology and Experimental Therapeutics. 307: 1127-34. PMID 14557376 DOI: 10.1124/jpet.103.055814 |
0.549 |
|
| 2003 |
Szabo I, Wetzel MA, Zhang N, Steele AD, Kaminsky DE, Chen C, Liu-Chen LY, Bednar F, Henderson EE, Howard OM, Oppenheim JJ, Rogers TJ. Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization. Journal of Leukocyte Biology. 74: 1074-82. PMID 12972507 DOI: 10.1189/Jlb.0203067 |
0.394 |
|
| 2003 |
Filipovska J, Gomes I, Xu W, Chen C, Liu-Chen LY, Devi LA. Recombinant opioid receptors. Structure-function relationship. Methods in Molecular Medicine. 84: 185-203. PMID 12703324 DOI: 10.1385/1-59259-379-8:185 |
0.52 |
|
| 2003 |
Li JG, Zhang F, Jin XL, Liu-Chen LY. Differential regulation of the human kappa opioid receptor by agonists: etorphine and levorphanol reduced dynorphin A- and U50,488H-induced internalization and phosphorylation. The Journal of Pharmacology and Experimental Therapeutics. 305: 531-40. PMID 12606694 DOI: 10.1124/jpet.102.045559 |
0.506 |
|
| 2002 |
Huang P, Visiers I, Weinstein H, Liu-Chen LY. The local environment at the cytoplasmic end of TM6 of the mu opioid receptor differs from those of rhodopsin and monoamine receptors: introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivates the mu opioid receptor and reduces the constitutive activity of its T6.34(279)K mutant. Biochemistry. 41: 11972-80. PMID 12356297 DOI: 10.1021/Bi026067B |
0.464 |
|
| 2002 |
Zhang F, Li J, Li JG, Liu-Chen LY. (-)U50,488H [(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide] induces internalization and down-regulation of the human, but not the rat, kappa-opioid receptor: structural basis for the differential regulation. The Journal of Pharmacology and Experimental Therapeutics. 302: 1184-92. PMID 12183679 DOI: 10.1124/jpet.302.3.1184 |
0.518 |
|
| 2002 |
Li JG, Chen C, Liu-Chen LY. Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate. The Journal of Biological Chemistry. 277: 27545-52. PMID 12004055 DOI: 10.1074/jbc.M200058200 |
0.506 |
|
| 2002 |
Li J, Li JG, Chen C, Zhang F, Liu-Chen LY. Molecular basis of differences in (-)(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny)-cyclohexyl]benzeneacetamide-induced desensitization and phosphorylation between human and rat kappa-opioid receptors expressed in Chinese hamster ovary cells. Molecular Pharmacology. 61: 73-84. PMID 11752208 DOI: 10.1124/mol.61.1.73 |
0.517 |
|
| 2001 |
Huang P, Li J, Chen C, Visiers I, Weinstein H, Liu-Chen LY. Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp. Biochemistry. 40: 13501-9. PMID 11695897 DOI: 10.1021/Bi010917Q |
0.506 |
|
| 2001 |
Li J, Chen C, Huang P, Liu-Chen LY. Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat mu-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation. Molecular Pharmacology. 60: 1064-75. PMID 11641435 DOI: 10.1124/Mol.60.5.1064 |
0.496 |
|
| 2001 |
Xu W, Li J, Chen C, Huang P, Weinstein H, Javitch JA, Shi L, de Riel JK, Liu-Chen LY. Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of mu, delta, and kappa opioid receptors. Biochemistry. 40: 8018-29. PMID 11434771 DOI: 10.1021/Bi002490D |
0.485 |
|
| 2001 |
Chen X, McClatchy DB, Geller EB, Liu-Chen L, Tallarida RJ, Adler MW. Possible mechanism of hypothermia induced by intracerebroventricular injection of orphanin FQ/nociceptin. Brain Research. 904: 252-8. PMID 11406123 DOI: 10.1016/S0006-8993(01)02467-2 |
0.546 |
|
| 2001 |
Huang P, Kehner GB, Cowan A, Liu-Chen LY. Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist. The Journal of Pharmacology and Experimental Therapeutics. 297: 688-95. PMID 11303059 |
0.512 |
|
| 2000 |
Xu W, Chen C, Huang P, Li J, de Riel JK, Javitch JA, Liu-Chen LY. The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors. Biochemistry. 39: 13904-15. PMID 11076532 DOI: 10.1021/bi001099p |
0.532 |
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| 2000 |
Li JG, Benovic JL, Liu-Chen LY. Mechanisms of agonist-induced down-regulation of the human kappa-opioid receptor: internalization is required for down-regulation. Molecular Pharmacology. 58: 795-801. PMID 10999950 |
0.449 |
|
| 2000 |
McFadyen IJ, Houshyar H, Liu-Chen LY, Woods JH, Traynor JR. The steroid 17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3, 5-dien-20-one (SC17599) is a selective mu-opioid agonist: implications for the mu-opioid pharmacophore. Molecular Pharmacology. 58: 669-76. PMID 10999935 DOI: 10.1124/Mol.58.4.669 |
0.604 |
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| 2000 |
Carman CV, Barak LS, Chen C, Liu-Chen LY, Onorato JJ, Kennedy SP, Caron MG, Benovic JL. Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. The Journal of Biological Chemistry. 275: 10443-52. PMID 10744734 DOI: 10.1074/jbc.275.14.10443 |
0.454 |
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| 2000 |
Li J, Benovic JL, Liu-Chen L. Mechanisms of Agonist-Induced Down-Regulation of the Human κ-Opioid Receptor: Internalization Is Required for Down-Regulation Molecular Pharmacology. 58: 795-801. DOI: 10.1124/Mol.58.4.795 |
0.53 |
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| 1999 |
Zhang D, Li JG, Chen C, Liu-Chen LY. Nucleoside diphosphate kinase associated with membranes modulates mu-opioid receptor-mediated [35S]GTPgammaS binding and agonist binding to mu-opioid receptor. European Journal of Pharmacology. 377: 223-31. PMID 10456435 DOI: 10.1016/S0014-2999(99)00387-8 |
0.578 |
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| 1999 |
Li JG, Chen C, Yin J, Rice K, Zhang Y, Matecka D, de Riel JK, DesJarlais RL, Liu-Chen LY. ASP147 in the third transmembrane helix of the rat mu opioid receptor forms ion-pairing with morphine and naltrexone. Life Sciences. 65: 175-85. PMID 10416823 DOI: 10.1016/S0024-3205(99)00234-9 |
0.578 |
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| 1999 |
Xu W, Ozdener F, Li JG, Chen C, de Riel JK, Weinstein H, Liu-Chen LY. Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor. Febs Letters. 447: 318-24. PMID 10214970 DOI: 10.1016/S0014-5793(99)00316-6 |
0.496 |
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| 1999 |
Li JG, Luo LY, Krupnick JG, Benovic JL, Liu-Chen LY. U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation. The Journal of Biological Chemistry. 274: 12087-94. PMID 10207034 DOI: 10.1074/jbc.274.17.12087 |
0.565 |
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| 1998 |
Chen C, Shahabi V, Xu W, Liu-Chen LY. Palmitoylation of the rat mu opioid receptor. Febs Letters. 441: 148-52. PMID 9877183 DOI: 10.1016/S0014-5793(98)01547-6 |
0.594 |
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| 1998 |
Alicea C, Belkowski SM, Sliker JK, Zhu J, Liu-Chen LY, Eisenstein TK, Adler MW, Rogers TJ. Characterization of kappa-opioid receptor transcripts expressed by T cells and macrophages. Journal of Neuroimmunology. 91: 55-62. PMID 9846819 DOI: 10.1016/S0165-5728(98)00151-9 |
0.459 |
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| 1998 |
Li JG, Raffa RB, Cheung P, Tzeng TB, Liu-Chen LY. Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor. European Journal of Pharmacology. 354: 227-37. PMID 9754924 DOI: 10.1016/S0014-2999(98)00444-0 |
0.493 |
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| 1998 |
Zhu J, Luo LY, Mao GF, Ashby B, Liu-Chen LY. Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in Chinese hamster ovary cells. The Journal of Pharmacology and Experimental Therapeutics. 285: 28-36. PMID 9535991 |
0.409 |
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| 1998 |
Lu YF, Xu H, Liu-Chen LY, Chen C, Partilla JS, Brine GA, Carroll FI, Rice KC, Lai J, Porreca F, Sadee W, Rothman RB. Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor. Synapse (New York, N.Y.). 28: 117-24. PMID 9450512 DOI: 10.1002/(Sici)1098-2396(199802)28:2<117::Aid-Syn2>3.0.Co;2-E |
0.495 |
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| 1997 |
Cheng PY, Liu-Chen LY, Pickel VM. Dual ultrastructural immunocytochemical labeling of mu and delta opioid receptors in the superficial layers of the rat cervical spinal cord. Brain Research. 778: 367-80. PMID 9459554 DOI: 10.1016/S0006-8993(97)00891-3 |
0.365 |
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| 1997 |
Chen C, Yin J, Li JG, Xue JC, Weerawarna SA, Nelson WL, Liu-Chen LY. Irreversible binding of N-methyl-N-[(1S)-1-(4-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl-3,4 -dichlorophenylacetamide to the cloned rat kappa opioid receptor. Life Sciences. 61: 787-94. PMID 9275008 DOI: 10.1016/S0024-3205(97)00560-2 |
0.499 |
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| 1997 |
Xin L, Geller EB, Liu-Chen LY, Chen C, Adler MW. Substance P release in the rat periaqueductal gray and preoptic anterior hypothalamus after noxious cold stimulation: effect of selective mu and kappa opioid agonists. The Journal of Pharmacology and Experimental Therapeutics. 282: 1055-63. PMID 9262375 |
0.327 |
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| 1997 |
Zhu J, Luo LY, Li JG, Chen C, Liu-Chen LY. Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands. The Journal of Pharmacology and Experimental Therapeutics. 282: 676-84. PMID 9262330 |
0.502 |
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| 1996 |
Chen XH, Geller EB, DeRiel JK, Liu-Chen LY, Adler MW. Antisense confirmation of mu- and kappa-opioid receptor mediation of morphine's effects on body temperature in rats. Drug and Alcohol Dependence. 43: 119-24. PMID 9023067 DOI: 10.1016/S0376-8716(96)01295-1 |
0.568 |
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| 1996 |
Chen XH, Liu-Chen LY, Tallarida RJ, Geller EB, de Riel JK, Adler MW. Use of a mu-antisense oligodeoxynucleotide as a mu opioid receptor noncompetitive antagonist in vivo. Neurochemical Research. 21: 1363-8. PMID 8947926 DOI: 10.1007/Bf02532377 |
0.514 |
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| 1996 |
Chen C, Yin J, Riel JK, DesJarlais RL, Raveglia LF, Zhu J, Liu-Chen LY. Determination of the amino acid residue involved in [3H]beta-funaltrexamine covalent binding in the cloned rat mu-opioid receptor. The Journal of Biological Chemistry. 271: 21422-9. PMID 8702924 DOI: 10.1074/jbc.271.35.21422 |
0.441 |
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| 1996 |
Zhu J, Xue JC, Law PY, Claude PA, Luo LY, Yin J, Chen C, Liu-Chen LY. The region in the mu opioid receptor conferring selectivity for sufentanil over the delta receptor is different from that over the kappa receptor. Febs Letters. 384: 198-202. PMID 8612823 DOI: 10.1016/0014-5793(96)00312-2 |
0.516 |
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| 1996 |
Zhu J, Yin J, Law PY, Claude PA, Rice KC, Evans CJ, Chen C, Yu L, Liu-Chen LY. Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain. The Journal of Biological Chemistry. 271: 1430-4. PMID 8576134 DOI: 10.1074/Jbc.271.3.1430 |
0.478 |
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| 1995 |
Chen XH, Geller EB, de Riel JK, Liu-Chen LY, Adler MW. Antisense oligodeoxynucleotides against mu- or kappa-opioid receptors block agonist-induced body temperature changes in rats. Brain Research. 688: 237-41. PMID 8542317 DOI: 10.1016/0006-8993(95)00564-7 |
0.523 |
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| 1995 |
Zhu J, Chen C, Xue JC, Kunapuli S, DeRiel JK, Liu-Chen LY. Cloning of a human kappa opioid receptor from the brain. Life Sciences. 56: PL201-7. PMID 7869844 DOI: 10.1016/0024-3205(94)00507-O |
0.527 |
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| 1995 |
Liu-Chen LY, Yang HH, Li S, Adams JU. Effect of intracerebroventricular beta-funaltrexamine on mu opioid receptors in the rat brain: consideration of binding condition. The Journal of Pharmacology and Experimental Therapeutics. 273: 1047-56. PMID 7791074 |
0.393 |
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| 1995 |
Chen XH, Adams JU, Geller EB, DeRiel JK, Adler MW, Liu-Chen LY. An antisense oligodeoxynucleotide to mu-opioid receptors inhibits mu-opioid receptor agonist-induced analgesia in rats. European Journal of Pharmacology. 275: 105-8. PMID 7774656 DOI: 10.1016/0014-2999(95)00012-A |
0.583 |
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| 1995 |
Xue JC, Chen C, Zhu J, Kunapuli SP, de Riel JK, Yu L, Liu-Chen LY. The third extracellular loop of the mu opioid receptor is important for agonist selectivity. The Journal of Biological Chemistry. 270: 12977-9. PMID 7768887 |
0.521 |
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| 1995 |
Chen C, Xue JC, Zhu J, Chen YW, Kunapuli S, Kim de Riel J, Yu L, Liu-Chen LY. Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor. The Journal of Biological Chemistry. 270: 17866-70. PMID 7629089 DOI: 10.1074/Jbc.270.30.17866 |
0.49 |
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| 1995 |
Prather PL, McGinn TM, Claude PA, Liu-Chen LY, Loh HH, Law PY. Properties of a kappa-opioid receptor expressed in CHO cells: interaction with multiple G-proteins is not specific for any individual G alpha subunit and is similar to that of other opioid receptors. Brain Research. Molecular Brain Research. 29: 336-46. PMID 7609621 DOI: 10.1016/0169-328X(94)00264-F |
0.423 |
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| 1995 |
Belkowski SM, Zhu J, Liu-Chen LY, Eisenstein TK, Adler MW, Rogers TJ. Detection of kappa-opioid receptor mRNA in immature T cells. Advances in Experimental Medicine and Biology. 373: 11-6. PMID 7545346 DOI: 10.1007/978-1-4615-1951-5_2 |
0.412 |
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| 1995 |
Belkowski SM, Zhu J, Liu-Chen LY, Eisenstein TK, Adler MW, Rogers TJ. Sequence of kappa-opioid receptor cDNA in the R1.1 thymoma cell line. Journal of Neuroimmunology. 62: 113-7. PMID 7499487 DOI: 10.1016/0165-5728(95)00116-J |
0.514 |
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| 1994 |
Kunapuli SP, Fen Mao G, Bastepe M, Liu-Chen LY, Li S, Cheung PP, DeRiel JK, Ashby B. Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells. The Biochemical Journal. 298: 263-7. PMID 8135729 DOI: 10.1042/Bj2980263 |
0.307 |
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| 1994 |
Xue JC, Chen C, Zhu J, Kunapuli S, DeRiel JK, Yu L, Liu-Chen LY. Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor. The Journal of Biological Chemistry. 269: 30195-9. PMID 7982926 |
0.506 |
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| 1994 |
Adams JU, Chen X, DeRiel JK, Adler MW, Liu-Chen LY. Intracerebroventricular treatment with an antisense oligodeoxynucleotide to kappa-opioid receptors inhibited kappa-agonist-induced analgesia in rats. Brain Research. 667: 129-32. PMID 7895075 DOI: 10.1016/0006-8993(94)91723-X |
0.57 |
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| 1994 |
Xue J, Chen C, Kunapuli S, DeRiel K, Yu L, Liu-Chen L. Identification of binding domains on κ opioid receptors: A chimeric μ/κ opioid receptor study Regulatory Peptides. 54: 335-336. DOI: 10.1016/0167-0115(94)90525-8 |
0.503 |
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| 1994 |
Chen C, Xue J, Kunapuli S, Chen YW, DeRiel K, Yu L, Liu-Chen LY. Determination of the region in the μ opioid receptor involved in covalent binding of β-FNA Regulatory Peptides. 54: 53-54. DOI: 10.1016/0167-0115(94)90385-9 |
0.421 |
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| 1994 |
Adams J, Chen X, DeRiel J, Adler M, Liu-Chen LY. In vivo treatment with antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats Regulatory Peptides. 54: 1-2. DOI: 10.1016/0167-0115(94)90359-X |
0.472 |
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| 1994 |
Liu-Chen LY, Yang HH, Li S, Adams J. Intracerebroventricular administration of ß-funaltrexamine (ß-FNA) reduces μ opioid receptor binding Regulatory Peptides. 53: S77-S78. DOI: 10.1016/0167-0115(94)90249-6 |
0.51 |
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| 1994 |
Li S, Zhu J, Chen C, Chen YW, Smyth RJ, Sakolsky DJ, Sheng S, Cao W, deRiel JK, Ashby B, Liu-Chen LY. Cloning and expression of a rat opioid receptor with κ characteristics Regulatory Peptides. 53: S11-S12. DOI: 10.1016/0167-0115(94)90216-X |
0.344 |
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| 1993 |
Bell J, Adler MW, Greenstein JI, Liu-Chen LY. Identification and characterization of [125I]arginine vasopressin binding sites on human peripheral blood mononuclear cells. Life Sciences. 52: 95-105. PMID 8417282 DOI: 10.1016/0024-3205(93)90292-B |
0.318 |
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| 1993 |
Li S, Zhu J, Chen C, Chen YW, Deriel JK, Ashby B, Liu-Chen LY. Molecular cloning and expression of a rat kappa opioid receptor. The Biochemical Journal. 295: 629-33. PMID 8240268 DOI: 10.1042/Bj2950629 |
0.59 |
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| 1993 |
Liu-Chen LY, Chen C, Phillips CA. Beta-[3H]funaltrexamine-labeled mu-opioid receptors: species variations in molecular mass and glycosylation by complex-type, N-linked oligosaccharides. Molecular Pharmacology. 44: 749-56. PMID 8232225 |
0.416 |
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| 1991 |
Liu-Chen LY, Li SX, Wheeler-Aceto H, Cowan A. Effects of intracerebroventricular beta-funaltrexamine on mu and delta opioid receptors in the rat: dichotomy between binding and antinociception. European Journal of Pharmacology. 203: 195-202. PMID 1666046 DOI: 10.1016/0014-2999(91)90715-3 |
0.466 |
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| 1991 |
Liu-Chen LY, Li SX, Lewis ME. Autoradiographic study of irreversible binding of [3H]beta-funaltrexamine to opioid receptors in the rat forebrain: comparison with mu and delta receptor distribution. Brain Research. 544: 235-42. PMID 1645609 DOI: 10.1016/0006-8993(91)90059-5 |
0.442 |
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| 1990 |
Liu-Chen LY, Li SX, Rohrbach KW, Lewis ME. [3H] beta-funaltrexamine ([3H] beta-FNA) binds irreversibly to mu opioid receptors in the rat brain: autoradiographic study. Progress in Clinical and Biological Research. 328: 61-4. PMID 2154819 |
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| 1990 |
Liu-Chen LY, Li S, Holowecky O, Tallarida RJ. Kinetic studies on binding of [3H] beta-funaltrexamine ([3H] beta-FNA) to mu opioid receptors. Progress in Clinical and Biological Research. 328: 57-60. PMID 2154818 |
0.354 |
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| 1990 |
Liu-Chen LY, Li SX, Tallarida RJ. Studies on kinetics of [3H]beta-funaltrexamine binding to mu opioid receptor. Molecular Pharmacology. 37: 243-50. PMID 2154672 |
0.388 |
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| 1990 |
Liu-Chen LY, Li S, Wheeler-Aceto H, Cowan A. Effects of intracerebroventricular β-funaltrexamine treatment on opioid receptors: Binding and behavioral studies New Leads in Opioid Research: Proceedings of the International Narcotics Research Conference. Ics914. 67-68. |
0.399 |
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| 1987 |
Liu-Chen LY, Phillips CA. Covalent labeling of mu opioid binding site by [3H]beta-funaltrexamine. Molecular Pharmacology. 32: 321-9. PMID 2823089 |
0.35 |
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| 1986 |
Tam SW, Liu-Chen LY. Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes. The Journal of Pharmacology and Experimental Therapeutics. 239: 351-7. PMID 3021954 |
0.342 |
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| 1985 |
Tam SW, Nickolson VJ, Liu-Chen LY. [3H]beta-funaltrexamine binds covalently to brain opioid receptors. European Journal of Pharmacology. 119: 259-60. PMID 3004996 DOI: 10.1016/0014-2999(85)90307-3 |
0.511 |
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