| Year |
Citation |
Score |
| 2016 |
Olincy A, Blakeley-Smith A, Johnson L, Kem WR, Freedman R. Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. PMID 27565651 DOI: 10.1007/S10803-016-2890-6 |
0.406 |
|
| 2016 |
Green BT, Lee ST, Welch KD, Cook D, Kem WR. Activation and Desensitization of Peripheral Muscle and Neuronal Nicotinic Acetylcholine Receptors by Selected, Naturally-Occurring Pyridine Alkaloids. Toxins. 8. PMID 27384586 DOI: 10.3390/Toxins8070204 |
0.431 |
|
| 2015 |
Leong RL, Xing H, Braekman JC, Kem WR. Non-competitive Inhibition of Nicotinic Acetylcholine Receptors by Ladybird Beetle Alkaloids. Neurochemical Research. 40: 2078-86. PMID 25370792 DOI: 10.1007/s11064-014-1466-0 |
0.435 |
|
| 2013 |
Isaacson MD, Horenstein NA, Stokes C, Kem WR, Papke RL. Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines. Biochemical Pharmacology. 85: 817-28. PMID 23352650 DOI: 10.1016/J.Bcp.2013.01.010 |
0.439 |
|
| 2010 |
Shen H, Kihara T, Hongo H, Wu X, Kem WR, Shimohama S, Akaike A, Niidome T, Sugimoto H. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. British Journal of Pharmacology. 161: 127-39. PMID 20718745 DOI: 10.1111/J.1476-5381.2010.00894.X |
0.318 |
|
| 2010 |
Stevens KE, Cornejo B, Adams CE, Zheng L, Yonchek J, Hoffman KL, Christians U, Kem WR. Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain Research. 1352: 140-6. PMID 20599427 DOI: 10.1016/J.Brainres.2010.06.063 |
0.486 |
|
| 2010 |
Slavov SH, Radzvilovits M, LeFrancois S, Stoyanova-Slavova IB, Soti F, Kem WR, Katritzky AR. A computational study of the binding of 3-(arylidene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein. European Journal of Medicinal Chemistry. 45: 2433-46. PMID 20236734 DOI: 10.1016/J.Ejmech.2010.02.027 |
0.494 |
|
| 2010 |
Green BT, Lee ST, Panter KE, Welch KD, Cook D, Pfister JA, Kem WR. Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors. Neurotoxicology and Teratology. 32: 383-90. PMID 20116429 DOI: 10.1016/J.Ntt.2010.01.011 |
0.366 |
|
| 2010 |
Tregellas JR, Olincy A, Johnson L, Tanabe J, Shatti S, Martin LF, Singel D, Du YP, Soti F, Kem WR, Freedman R. Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 938-42. PMID 19956085 DOI: 10.1038/Npp.2009.196 |
0.302 |
|
| 2009 |
López-Hernández GY, Thinschmidt JS, Morain P, Trocme-Thibierge C, Kem WR, Soti F, Papke RL. Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795. Neuropharmacology. 56: 821-30. PMID 19705574 DOI: 10.1016/J.Neuropharm.2009.01.011 |
0.395 |
|
| 2009 |
Hibbs RE, Sulzenbacher G, Shi J, Talley TT, Conrod S, Kem WR, Taylor P, Marchot P, Bourne Y. Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. The Embo Journal. 28: 3040-51. PMID 19696737 DOI: 10.1038/Emboj.2009.227 |
0.455 |
|
| 2009 |
Arias HR, Xing H, Macdougall K, Blanton MP, Soti F, Kem WR. Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors. British Journal of Pharmacology. 157: 320-30. PMID 19338581 DOI: 10.1111/J.1476-5381.2009.00156.X |
0.509 |
|
| 2009 |
Papke RL, Kem WR, Soti F, López-Hernández GY, Horenstein NA. Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine. The Journal of Pharmacology and Experimental Therapeutics. 329: 791-807. PMID 19223664 DOI: 10.1124/Jpet.108.150151 |
0.489 |
|
| 2008 |
Rowland NE, Robertson K, Soti F, Kem WR. Nicotine analog inhibition of nicotine self-administration in rats. Psychopharmacology. 199: 605-13. PMID 18536909 DOI: 10.1007/S00213-008-1186-8 |
0.403 |
|
| 2008 |
Freedman R, Olincy A, Buchanan RW, Harris JG, Gold JM, Johnson L, Allensworth D, Guzman-Bonilla A, Clement B, Ball MP, Kutnick J, Pender V, Martin LF, Stevens KE, Wagner BD, ... ... Kem WR, et al. Initial phase 2 trial of a nicotinic agonist in schizophrenia. The American Journal of Psychiatry. 165: 1040-7. PMID 18381905 DOI: 10.1176/Appi.Ajp.2008.07071135 |
0.327 |
|
| 2006 |
Talley TT, Yalda S, Ho KY, Tor Y, Soti FS, Kem WR, Taylor P. Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions. Biochemistry. 45: 8894-902. PMID 16846232 DOI: 10.1021/Bi060534Y |
0.319 |
|
| 2006 |
Zhang R, White NA, Soti FS, Kem WR, Machu TK. N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine. The Journal of Pharmacology and Experimental Therapeutics. 317: 1276-84. PMID 16551836 DOI: 10.1124/Jpet.106.101485 |
0.38 |
|
| 2006 |
Lee ST, Wildeboer K, Panter KE, Kem WR, Gardner DR, Molyneux RJ, Chang CW, Soti F, Pfister JA. Relative toxicities and neuromuscular nicotinic receptor agonistic potencies of anabasine enantiomers and anabaseine. Neurotoxicology and Teratology. 28: 220-8. PMID 16488116 DOI: 10.1016/J.Ntt.2005.12.010 |
0.573 |
|
| 2004 |
Kem WR, Wildeboer K, LeFrancois S, Raja M, Marszalec W, Braekman JC. Nicotinic receptor inhibition by Tetraponera ant alkaloids. Cellular and Molecular Neurobiology. 24: 535-51. PMID 15233377 DOI: 10.1023/B:Cemn.0000023628.65936.A7 |
0.582 |
|
| 2004 |
Stokes C, Papke JK, Horenstein NA, Kem WR, McCormack TJ, Papke RL. The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors. Molecular Pharmacology. 66: 14-24. PMID 15213292 DOI: 10.1124/Mol.66.1.14 |
0.378 |
|
| 2004 |
Martin LF, Kem WR, Freedman R. Alpha-7 nicotinic receptor agonists: Potential new candidates for the treatment of schizophrenia Psychopharmacology. 174: 54-64. PMID 15205879 DOI: 10.1007/S00213-003-1750-1 |
0.395 |
|
| 2004 |
Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F. Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Molecular Pharmacology. 65: 56-67. PMID 14722237 DOI: 10.1124/Mol.65.1.56 |
0.587 |
|
| 2003 |
Kem WR, Soti F, Rittschof D. Inhibition of barnacle larval settlement and crustacean toxicity of some hoplonemertine pyridyl alkaloids. Biomolecular Engineering. 20: 355-61. PMID 12919820 DOI: 10.1016/S1389-0344(03)00049-2 |
0.303 |
|
| 2003 |
Arias HR, Kem WR, Trudell JR, Blanton MP. Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor. International Review of Neurobiology. 54: 1-50. PMID 12785284 DOI: 10.1016/S0074-7742(03)54002-8 |
0.407 |
|
| 2003 |
O'Neill HC, Rieger K, Kem WR, Stevens KE. DMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats. Psychopharmacology. 169: 332-9. PMID 12759805 DOI: 10.1007/S00213-003-1482-2 |
0.437 |
|
| 2003 |
Arias HR, Kem WR, Trudell JR, Blanton MP. Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor International Review of Neurobiology. 54: 1-50. DOI: 10.1016/S0074-7742(03)54002-8 |
0.426 |
|
| 2001 |
Machu TK, Hamilton ME, Frye TF, Shanklin CL, Harris MC, Sun H, Tenner TE, Soti FS, Kem WR. Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor. The Journal of Pharmacology and Experimental Therapeutics. 299: 1112-9. PMID 11714901 |
0.305 |
|
| 2001 |
Simosky JK, Stevens KE, Kem WR, Freedman R. Intragastric DMXB-A, an alpha7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice. Biological Psychiatry. 50: 493-500. PMID 11600102 DOI: 10.1016/S0006-3223(01)01093-9 |
0.303 |
|
| 2001 |
Kem WR, Soti F. Amphiporus alkaloid multiplicity implies functional diversity: Initial studies on crustacean pyridyl receptors Hydrobiologia. 456: 221-231. DOI: 10.1023/A:1013063726807 |
0.439 |
|
| 2000 |
Adams CE, Stevens KE, Kem WR, Freedman R. Inhibition of nitric oxide synthase prevents alpha 7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampus. Brain Research. 877: 235-44. PMID 10986337 DOI: 10.1016/S0006-8993(00)02677-9 |
0.401 |
|
| 2000 |
Kem WR. The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21). Behavioural Brain Research. 113: 169-81. PMID 10942043 DOI: 10.1016/S0166-4328(00)00211-4 |
0.555 |
|
| 1999 |
Stevens KE, Kem WR, Freedman R. Selective alpha 7 nicotinic receptor stimulation normalizes chronic cocaine-induced loss of hippocampal sensory inhibition in C3H mice. Biological Psychiatry. 46: 1443-50. PMID 10578459 DOI: 10.1016/S0006-3223(99)00200-0 |
0.362 |
|
| 1999 |
van Haaren F, Anderson KG, Haworth SC, Kem WR. GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue. Pharmacology, Biochemistry, and Behavior. 64: 439-44. PMID 10515327 DOI: 10.1016/S0091-3057(99)00054-4 |
0.493 |
|
| 1998 |
Stevens KE, Kem WR, Mahnir VM, Freedman R. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology. 136: 320-7. PMID 9600576 DOI: 10.1007/S002130050573 |
0.437 |
|
| 1997 |
Kem WR. Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist. Invertebrate Neuroscience : In. 3: 251-9. PMID 9783447 DOI: 10.1007/Bf02480382 |
0.362 |
|
| 1997 |
Kem WR, Mahnir VM, Papke RL, Lingle CJ. Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. The Journal of Pharmacology and Experimental Therapeutics. 283: 979-92. PMID 9399967 |
0.559 |
|
| 1997 |
Summers KL, Kem WR, Giacobini E. Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex. Japanese Journal of Pharmacology. 74: 139-46. PMID 9243321 DOI: 10.1254/Jjp.74.139 |
0.44 |
|
| 1996 |
Bjugstad KB, Mahnir VM, Kem WR, Socci DJ, Arendash GW. Long-term treatment with GTS-21 or nicotine enhances water maze performance in aged rats without affecting the density of nicotinic receptor subtypes in neocortex Drug Development Research. 39: 19-28. DOI: 10.1002/(Sici)1098-2299(19960901)39:1<19::Aid-Ddr3>3.0.Co;2-N |
0.468 |
|
| 1995 |
de Fiebre CM, Meyer EM, Henry JC, Muraskin SI, Kem WR, Papke RL. Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes. Molecular Pharmacology. 47: 164-71. PMID 7838125 |
0.496 |
|
| 1995 |
Arendash GW, Sengstock GJ, Sanberg PR, Kem WR. Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Research. 674: 252-9. PMID 7796104 DOI: 10.1016/0006-8993(94)01449-R |
0.347 |
|
| 1994 |
Woodruff-Pak DS, Li YT, Kem WR. A nicotinic agonist (GTS-21), eyeblink classical conditioning, and nicotinic receptor binding in rabbit brain. Brain Research. 645: 309-17. PMID 8062092 DOI: 10.1016/0006-8993(94)91665-9 |
0.376 |
|
| 1994 |
Hunter BE, de Fiebre CM, Papke RL, Kem WR, Meyer EM. A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus. Neuroscience Letters. 168: 130-4. PMID 8028765 DOI: 10.1016/0304-3940(94)90433-2 |
0.514 |
|
| 1994 |
Woodruff-Pak DS, Li YT, Kazmi A, Kem WR. Nicotinic cholinergic system involvement in eyeblink classical conditioning in rabbits. Behavioral Neuroscience. 108: 486-93. PMID 7917042 DOI: 10.1037//0735-7044.108.3.486 |
0.392 |
|
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