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Christopher M. Koth, Ph.D. - Publications

Affiliations: 
2002 University of Toronto, Toronto, ON, Canada 
Area:
Molecular Biology
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rougé L, Chiang N, Steffek M, Kugel C, Croll TI, Tam C, Estevez A, Arthur CP, Koth CM, Ciferri C, Kraft E, Payandeh J, Nakamura G, Koerber JT, Rohou A. Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab. Science (New York, N.Y.). PMID 32079680 DOI: 10.1126/Science.Aaz9356  0.318
2019 Tzakoniati F, Xu H, Li T, Garcia N, Kugel C, Payandeh J, Koth CM, Tate EW. Development of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7. Cell Chemical Biology. PMID 31732432 DOI: 10.1016/J.Chembiol.2019.10.011  0.339
2019 Xu H, Clairfeuille T, Jao CC, Ho H, Sweeney Z, Payandeh J, Koth CM. A Flexible and Scalable High-Throughput Platform for Recombinant Membrane Protein Production. Methods in Molecular Biology (Clifton, N.J.). 2025: 389-402. PMID 31267463 DOI: 10.1007/978-1-4939-9624-7_18  0.323
2019 Storek KM, Chan J, Vij R, Chiang N, Lin Z, Bevers J, Koth CM, Vernes JM, Meng YG, Yin J, Wallweber H, Dalmas O, Shriver S, Tam C, Schneider K, et al. Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptD. Elife. 8. PMID 31237236 DOI: 10.7554/Elife.46258  0.355
2019 Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J. Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell. PMID 30661758 DOI: 10.2210/Pdb6N4Q/Pdb  0.348
2019 Storek KM, Chan J, Vij R, Chiang N, Lin Z, Bevers J, Koth CM, Vernes J, Meng YG, Yin J, Wallweber H, Dalmas O, Shriver S, Tam C, Schneider K, et al. Author response: Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD Elife. DOI: 10.7554/Elife.46258.022  0.309
2019 Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J. Structural basis of selective Nav1.7 inhibition by a gating-modifier spider toxin Cell. DOI: 10.2210/Pdb6N4I/Pdb  0.317
2019 Xu H, Li T, Rohou A, Arthur C, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos D, Koth C, Payandeh J. Structural Basis of Nav1.7 Inhibition by the Tarantula Toxin Protoxin-II Biophysical Journal. 116: 311a. DOI: 10.1016/J.Bpj.2018.11.1687  0.302
2018 Alexander MK, Miu A, Oh A, Reichelt M, Ho H, Chalouni C, Labadie S, Wang L, Liang J, Nickerson NN, Hu H, Yu L, Du M, Yan D, Park S, ... ... Koth CM, et al. Disrupting Gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA. Antimicrobial Agents and Chemotherapy. PMID 30104274 DOI: 10.1128/Aac.01142-18  0.326
2018 Vij R, Lin Z, Chiang N, Vernes JM, Storek KM, Park S, Chan J, Meng YG, Comps-Agrar L, Luan P, Lee S, Schneider K, Bevers J, Zilberleyb I, Tam C, ... Koth CM, et al. A targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies. Scientific Reports. 8: 7136. PMID 29740124 DOI: 10.1038/S41598-018-25609-Z  0.354
2018 Ho H, Miu A, Alexander MK, Garcia NK, Oh A, Zilberleyb I, Reichelt M, Austin CD, Tam C, Shriver S, Hu H, Labadie SS, Liang J, Wang L, Wang J, ... ... Koth CM, et al. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. PMID 29720648 DOI: 10.1038/S41586-018-0083-5  0.381
2018 Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Kömüves LG, Modrusan Z, Angers S, Franke Y, Koth C, Fairbrother WJ, et al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nature Chemical Biology. PMID 29632413 DOI: 10.1038/S41589-018-0035-2  0.361
2018 Nickerson NN, Jao CC, Xu Y, Quinn J, Skippington E, Alexander MK, Miu A, Skelton N, Hankins JV, Lopez MS, Koth CM, Rutherford S, Nishiyama M. A novel inhibitor of the LolCDE ABC transporter essential for lipoprotein trafficking in Gram-negative bacteria. Antimicrobial Agents and Chemotherapy. PMID 29339384 DOI: 10.1128/Aac.02151-17  0.344
2015 Ahuja S, Mukund S, Deng L, Khakh K, Chang E, Ho H, Shriver S, Young C, Lin S, Johnson JP, Wu P, Li J, Coons M, Tam C, Brillantes B, ... ... Koth CM, et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science (New York, N.Y.). 350: aac5464. PMID 26680203 DOI: 10.1126/Science.Aac5464  0.346
2015 Ahuja S, Rougé L, Swem DL, Sudhamsu J, Wu P, Russell SJ, Alexander MK, Tam C, Nishiyama M, Starovasnik MA, Koth CM. Structural analysis of bacterial ABC transporter inhibition by an antibody fragment. Structure (London, England : 1993). 23: 713-23. PMID 25752540 DOI: 10.1016/J.Str.2015.01.020  0.395
2013 Mukund S, Shang Y, Clarke HJ, Madjidi A, Corn JE, Kates L, Kolumam G, Chiang V, Luis E, Murray J, Zhang Y, Hötzel I, Koth CM, Allan BB. Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor. The Journal of Biological Chemistry. 288: 36168-78. PMID 24189067 DOI: 10.1074/Jbc.M113.496984  0.339
2013 Hazenbos WL, Kajihara KK, Vandlen R, Morisaki JH, Lehar SM, Kwakkenbos MJ, Beaumont T, Bakker AQ, Phung Q, Swem LR, Ramakrishnan S, Kim J, Xu M, Shah IM, Diep BA, ... ... Koth C, et al. Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins. Plos Pathogens. 9: e1003653. PMID 24130480 DOI: 10.1371/Journal.Ppat.1003653  0.355
2012 Koth CM, Murray JM, Mukund S, Madjidi A, Minn A, Clarke HJ, Wong T, Chiang V, Luis E, Estevez A, Rondon J, Zhang Y, Hötzel I, Allan BB. Molecular basis for negative regulation of the glucagon receptor. Proceedings of the National Academy of Sciences of the United States of America. 109: 14393-8. PMID 22908259 DOI: 10.1073/Pnas.1206734109  0.349
2010 ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM. Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure (London, England : 1993). 18: 1083-93. PMID 20826335 DOI: 10.1016/J.Str.2010.05.014  0.344
2010 Koth CM, Abdul-Manan N, Lepre CA, Connolly PJ, Yoo S, Mohanty AK, Lippke JA, Zwahlen J, Coll JT, Doran JD, Garcia-Guzman M, Moore JM. Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor. Biochemistry. 49: 1862-72. PMID 20099900 DOI: 10.1021/Bi901848M  0.354
2008 Willis MS, Koth CM. Structural proteomics of membrane proteins: a survey of published techniques and design of a rational high throughput strategy. Methods in Molecular Biology (Clifton, N.J.). 426: 277-95. PMID 18542871 DOI: 10.1007/978-1-60327-058-8_18  0.365
2007 Dobrovetsky E, Menendez J, Edwards AM, Koth CM. A robust purification strategy to accelerate membrane proteomics. Methods (San Diego, Calif.). 41: 381-7. PMID 17367710 DOI: 10.1016/J.Ymeth.2006.08.009  0.352
2006 Lunin VV, Dobrovetsky E, Khutoreskaya G, Zhang R, Joachimiak A, Doyle DA, Bochkarev A, Maguire ME, Edwards AM, Koth CM. Crystal structure of the CorA Mg2+ transporter. Nature. 440: 833-7. PMID 16598263 DOI: 10.1038/Nature04642  0.33
2005 Dobrovetsky E, Lu ML, Andorn-Broza R, Khutoreskaya G, Bray JE, Savchenko A, Arrowsmith CH, Edwards AM, Koth CM. High-throughput production of prokaryotic membrane proteins. Journal of Structural and Functional Genomics. 6: 33-50. PMID 15909233 DOI: 10.1007/S10969-005-1363-5  0.369
2005 Lemberg MK, Menendez J, Misik A, Garcia M, Koth CM, Freeman M. Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. The Embo Journal. 24: 464-72. PMID 15616571 DOI: 10.1038/Sj.Emboj.7600537  0.375
2003 Koth CM, Orlicky SM, Larson SM, Edwards AM. Use of limited proteolysis to identify protein domains suitable for structural analysis. Methods in Enzymology. 368: 77-84. PMID 14674269 DOI: 10.1016/S0076-6879(03)68005-5  0.376
2003 Koth CM, Edwards AM. From clone to crystal: maximizing the amount of protein samples for structure determination. Advances in Protein Chemistry. 65: 343-352. PMID 12964375 DOI: 10.1016/S0065-3233(03)01025-8  0.352
2001 Botuyan MV, Mer G, Yi GS, Koth CM, Case DA, Edwards AM, Chazin WJ, Arrowsmith CH. Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide Journal of Molecular Biology. 312: 177-186. PMID 11545595 DOI: 10.1006/Jmbi.2001.4938  0.377
2000 Booth V, Koth CM, Edwards AM, Arrowsmith CH. Structure of a conserved domain common to the transcription factors TFIIS, Elongin A, and CRSP70 Journal of Biological Chemistry. 275: 31266-31268. PMID 10811649 DOI: 10.1074/Jbc.M002595200  0.343
2000 Koth CM, Botuyan MV, Moreland RJ, Jansma DB, Conaway JW, Conaway RC, Chazin WJ, Friesen JD, Arrowsmith CH, Edwards AM. Elongin from Saccharomyces cerevisiae. The Journal of Biological Chemistry. 275: 11174-80. PMID 10753924 DOI: 10.1074/Jbc.275.15.11174  0.532
1999 Botuyan MV, Koth CM, Mer G, Chakrabartty A, Conaway JW, Conaway RC, Edwards AM, Arrowsmith CH, Chazin WJ. Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C Proceedings of the National Academy of Sciences of the United States of America. 96: 9033-9038. PMID 10430890 DOI: 10.1073/Pnas.96.16.9033  0.387
1998 Awrey DE, Shimasaki N, Koth C, Weilbaecher R, Olmsted V, Kazanis S, Shan X, Arellano J, Arrowsmith CH, Kane CM, Edwards AM. Yeast transcript elongation factor (TFIIS), structure and function. II: RNA polymerase binding, transcript cleavage, and read-through. The Journal of Biological Chemistry. 273: 22595-605. PMID 9712888 DOI: 10.1074/Jbc.273.35.22595  0.337
1998 Olmsted VK, Awrey DE, Koth C, Shan X, Morin PE, Kazanis S, Edwards AM, Arrowsmith CH. Yeast transcript elongation factor (TFIIS), structure and function. I: NMR structural analysis of the minimal transcriptionally active region. The Journal of Biological Chemistry. 273: 22589-94. PMID 9712887 DOI: 10.1074/Jbc.273.35.22589  0.355
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