Richard Weindruch - Publications

Affiliations: 
Medicine University of Wisconsin, Madison, Madison, WI 

150 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Mastaloudis A, Serna E, Wood S, Hester S, Weindruch R, Prolla T, Viña J. A novel nutrient blend mimics calorie restriction transcriptomics in multiple tissues of mice and increases vitality and lifespan in C. elegans Free Radical Biology and Medicine. 120: S15. DOI: 10.1016/J.Freeradbiomed.2018.04.066  0.687
2017 Barger JL, Vann JM, Cray NL, Pugh TD, Mastaloudis A, Hester SN, Wood SM, Newton MA, Weindruch R, Prolla TA. Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics. Aging Cell. PMID 28556428 DOI: 10.1111/Acel.12608  0.651
2017 Yamada Y, Kemnitz JW, Weindruch R, Anderson RM, Schoeller DA, Colman RJ. Caloric Restriction and Healthy Life Span: Frail Phenotype of Nonhuman Primates in the Wisconsin National Primate Research Center Caloric Restriction Study. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 28398464 DOI: 10.1093/Gerona/Glx059  0.324
2017 Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA. Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice. Plos One. 12: e0171159. PMID 28158260 DOI: 10.1371/Journal.Pone.0171159  0.648
2017 Mattison JA, Colman RJ, Beasley TM, Allison DB, Kemnitz JW, Roth GS, Ingram DK, Weindruch R, de Cabo R, Anderson RM. Caloric restriction improves health and survival of rhesus monkeys. Nature Communications. 8: 14063. PMID 28094793 DOI: 10.1038/Ncomms14063  0.387
2017 Mastaloudis A, Serna E, Wood SM, Hester S, Weindruch R, Prolla TA, Vina J. A novel nutrient blend mimics calorie restriction transcriptomics differentially in multiple tissues of mice Free Radical Biology and Medicine. 108: S99. DOI: 10.1016/J.Freeradbiomed.2017.04.320  0.691
2015 Barger JL, Anderson RM, Newton MA, da Silva C, Vann JA, Pugh TD, Someya S, Prolla TA, Weindruch R. A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. Plos One. 10: e0120738. PMID 25830335 DOI: 10.1371/Journal.Pone.0120738  0.683
2014 Colman RJ, Beasley TM, Kemnitz JW, Johnson SC, Weindruch R, Anderson RM. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nature Communications. 5: 3557. PMID 24691430 DOI: 10.1038/Ncomms4557  0.465
2014 Barger J, Vann J, Mastaloudis A, Wood S, Bartlett M, Prolla T, Weindruch R. Identification of transcriptional targets of healthspan in adipose tissue and modulation by resveratrol Nutrition and Aging. 2: 157-163. DOI: 10.3233/NUA-130018  0.499
2013 Collino S, Martin FP, Montoliu I, Barger JL, Da Silva L, Prolla TA, Weindruch R, Kochhar S. Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains. Metabolites. 3: 881-911. PMID 24958256 DOI: 10.3390/Metabo3040881  0.645
2013 Yamada Y, Colman RJ, Kemnitz JW, Baum ST, Anderson RM, Weindruch R, Schoeller DA. Long-term calorie restriction decreases metabolic cost of movement and prevents decrease of physical activity during aging in rhesus monkeys. Experimental Gerontology. 48: 1226-35. PMID 23954367 DOI: 10.1016/J.Exger.2013.08.002  0.36
2013 Pugh TD, Conklin MW, Evans TD, Polewski MA, Barbian HJ, Pass R, Anderson BD, Colman RJ, Eliceiri KW, Keely PJ, Weindruch R, Beasley TM, Anderson RM. A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys. Aging Cell. 12: 672-81. PMID 23607901 DOI: 10.1111/Acel.12091  0.409
2013 Oriaku ET, Chen F, Desai VG, Pipkin JL, Shaddock JG, Weindruch R, Hart RW, Feuers RJ. A circadian study of liver antioxidant enzyme systems of female Fischer-344 rats subjected to dietary restriction for six weeks. Age. 20: 221-8. PMID 23604324 DOI: 10.1007/S11357-997-0022-0  0.332
2013 Feuers RJ, Weindruch R, Leakey JE, Duffy PH, Hart RW. Increased effective activity of rat liver catalase by dietary restriction. Age. 20: 215-20. PMID 23604323 DOI: 10.1007/S11357-997-0021-1  0.335
2013 Csiszar A, Sosnowska D, Tucsek Z, Gautam T, Toth P, Losonczy G, Colman RJ, Weindruch R, Anderson RM, Sonntag WE, Ungvari Z. Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 235-49. PMID 22904098 DOI: 10.1093/Gerona/Gls158  0.307
2013 Sridharan A, Kemnitz J, Colman R, Weindruch R, Johnson S. Brain aging and calorie restriction in rhesus macaques Experimental Gerontology. 48: 695. DOI: 10.1016/J.Exger.2013.05.041  0.363
2012 Anderson RM, Weindruch R. The caloric restriction paradigm: implications for healthy human aging. American Journal of Human Biology : the Official Journal of the Human Biology Council. 24: 101-6. PMID 22290875 DOI: 10.1002/Ajhb.22243  0.436
2012 McKiernan SH, Colman RJ, Aiken E, Evans TD, Beasley TM, Aiken JM, Weindruch R, Anderson RM. Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys. Experimental Gerontology. 47: 229-36. PMID 22226624 DOI: 10.1016/J.Exger.2011.12.009  0.399
2012 Barger JL, Kayo T, Pugh TD, Vann JA, Power R, Dawson K, Weindruch R, Prolla TA. Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse. Genes & Nutrition. 7: 155-65. PMID 21847681 DOI: 10.1007/S12263-011-0243-9  0.636
2012 Mastaloudis⁎ A, Barger J, Prolla T, Weindruch R, Wood S. A unique blend of natural compounds opposes age-related changes in gene expression related to dysregulation of cellular detoxification and antioxidant protection Free Radical Biology and Medicine. 53: S83. DOI: 10.1016/J.Freeradbiomed.2012.08.173  0.643
2011 McKiernan SH, Colman RJ, Lopez M, Beasley TM, Aiken JM, Anderson RM, Weindruch R. Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle. Experimental Gerontology. 46: 23-9. PMID 20883771 DOI: 10.1016/J.Exger.2010.09.011  0.357
2011 Willette A, Bendlin B, Colman R, Kastman E, Field A, Alexander A, Sridharan A, Allison D, Anderson R, Voytko M, Kemnitz J, Weindruch R, Johnson S. 168. Calorie restriction abrogates the influence of glucoregulatory dysfunction on brain volume in aged rhesus monkeys Brain Behavior and Immunity. 25. DOI: 10.1016/J.Bbi.2011.07.171  0.358
2010 Someya S, Tanokura M, Weindruch R, Prolla TA, Yamasoba T. Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys. Current Aging Science. 3: 20-5. PMID 20298166 DOI: 10.2174/1874609811003010020  0.664
2010 Fowler CG, Chiasson KB, Leslie TH, Thomas D, Beasley TM, Kemnitz JW, Weindruch R. Auditory function in rhesus monkeys: effects of aging and caloric restriction in the Wisconsin monkeys five years later. Hearing Research. 261: 75-81. PMID 20079820 DOI: 10.1016/J.Heares.2010.01.006  0.427
2010 Anderson RM, Weindruch R. Metabolic reprogramming, caloric restriction and aging. Trends in Endocrinology and Metabolism: Tem. 21: 134-41. PMID 20004110 DOI: 10.1016/J.Tem.2009.11.005  0.442
2009 Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 106: 19432-7. PMID 19901338 DOI: 10.1073/Pnas.0908786106  0.639
2009 Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science (New York, N.Y.). 325: 201-4. PMID 19590001 DOI: 10.1126/Science.1173635  0.419
2009 Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA. Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell. 8: 484-95. PMID 19555370 DOI: 10.1111/J.1474-9726.2009.00496.X  0.697
2009 Rezzi S, Martin FP, Shanmuganayagam D, Colman RJ, Nicholson JK, Weindruch R. Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates. Experimental Gerontology. 44: 356-62. PMID 19264119 DOI: 10.1016/J.Exger.2009.02.008  0.403
2009 Anderson RM, Shanmuganayagam D, Weindruch R. Caloric restriction and aging: studies in mice and monkeys. Toxicologic Pathology. 37: 47-51. PMID 19075044 DOI: 10.1177/0192623308329476  0.471
2009 McKiernan SH, Colman R, Lopez M, Beasley TM, Weindruch R, Aiken JM. Longitudinal analysis of early stage sarcopenia in aging rhesus monkeys. Experimental Gerontology. 44: 170-6. PMID 18983905 DOI: 10.1016/J.Exger.2008.09.014  0.344
2009 Hagopian K, Ramsey JJ, Weindruch R. Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver. Biogerontology. 10: 471-9. PMID 18953666 DOI: 10.1007/S10522-008-9191-1  0.403
2009 Li H, Costantini C, Scrable H, Weindruch R, Puglielli L. Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R. Neurobiology of Aging. 30: 2010-20. PMID 18378044 DOI: 10.1016/J.Neurobiolaging.2008.02.015  0.322
2008 Fu VX, Dobosy JR, Desotelle JA, Almassi N, Ewald JA, Srinivasan R, Berres M, Svaren J, Weindruch R, Jarrard DF. Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate. Cancer Research. 68: 6797-802. PMID 18701505 DOI: 10.1158/0008-5472.Can-08-1714  0.338
2008 Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R. Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart Experimental Gerontology. 43: 859-866. PMID 18657603 DOI: 10.1016/J.Exger.2008.06.013  0.687
2008 Colman RJ, Beasley TM, Allison DB, Weindruch R. Attenuation of sarcopenia by dietary restriction in rhesus monkeys Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 63: 556-559. PMID 18559628 DOI: 10.1093/Gerona/63.6.556  0.367
2008 Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. Plos One. 3: e2264. PMID 18523577 DOI: 10.1371/Journal.Pone.0002264  0.687
2008 Park SK, Page GP, Kim K, Allison DB, Meydani M, Weindruch R, Prolla TA. alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice. The Journal of Nutrition. 138: 1010-8. PMID 18492827 DOI: 10.1093/Jn/138.6.1010  0.688
2008 Hagopian K, Ramsey JJ, Weindruch R. Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities. Bioscience Reports. 28: 107-15. PMID 18429748 DOI: 10.1042/Bsr20080015  0.41
2008 Fowler CG, Chiasson KB, Hart DB, Beasley TM, Kemnitz J, Weindruch R. Tympanometry in rhesus monkeys: Effects of aging and caloric restriction International Journal of Audiology. 47: 209-214. PMID 18389417 DOI: 10.1080/14992020701851882  0.413
2008 Anderson RM, Barger JL, Edwards MG, Braun KH, O'Connor CE, Prolla TA, Weindruch R. Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response. Aging Cell. 7: 101-11. PMID 18031569 DOI: 10.1111/J.1474-9726.2007.00357.X  0.56
2008 Someya S, Yamasoba T, Kujoth GC, Pugh TD, Weindruch R, Tanokura M, Prolla TA. The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma. Neurobiology of Aging. 29: 1080-92. PMID 17363114 DOI: 10.1016/J.Neurobiolaging.2007.01.014  0.626
2008 Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice Plos One. 3. DOI: 10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5  0.595
2008 Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice Plos One. 3. DOI: 10.1371/annotation/8333176c-b08c-4dfb-a829-6331c0fc6064  0.595
2008 Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice Plos One. 3. DOI: 10.1371/annotation/7d56e94e-3582-413d-b987-fccd0da79081  0.595
2008 Weindruch R, Colman RJ, Pérez V, Richardson AG. 15 How Does Caloric Restriction Increase the Longevity of Mammals Cold Spring Harbor Monograph Archive. 51: 409-425. DOI: 10.1101/087969824.51.409  0.311
2007 Raman A, Baum ST, Colman RJ, Kemnitz JW, Weindruch R, Schoeller DA. Metabolizable energy intake during long-term calorie restriction in rhesus monkeys. Experimental Gerontology. 42: 988-94. PMID 17618073 DOI: 10.1016/J.Exger.2007.05.008  0.304
2007 Edwards MG, Anderson RM, Yuan M, Kendziorski CM, Weindruch R, Prolla TA. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. Bmc Genomics. 8: 80. PMID 17381838 DOI: 10.1186/1471-2164-8-80  0.671
2007 Raman A, Ramsey JJ, Kemnitz JW, Baum ST, Newton W, Colman RJ, Weindruch R, Beasley MT, Schoeller DA. Influences of calorie restriction and age on energy expenditure in the rhesus monkey. American Journal of Physiology. Endocrinology and Metabolism. 292: E101-6. PMID 16896169 DOI: 10.1152/Ajpendo.00127.2006  0.375
2007 Someya S, Yamasoba T, Weindruch R, Prolla TA, Tanokura M. Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis. Neurobiology of Aging. 28: 1613-22. PMID 16890326 DOI: 10.1016/J.Neurobiolaging.2006.06.024  0.643
2007 Yamasoba T, Someya S, Yamada C, Weindruch R, Prolla TA, Tanokura M. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hearing Research. 226: 185-93. PMID 16870370 DOI: 10.1016/J.Heares.2006.06.004  0.634
2006 Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/J.Cell.2006.06.057  0.586
2006 Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R. Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. The Journal of Nutrition. 136: 343-52. PMID 16424110 DOI: 10.1093/Jn/136.2.343  0.629
2006 Weindruch R. Calorie Restriction and Aging Scientific American Sp. 16: 54-61. DOI: 10.1016/S0002-9394(14)70309-5  0.436
2006 Wang C, Li Q, Redden DT, Weindruch R, Allison DB. Erratum to “Statistical methods for testing effects on ‘maximum lifespan”’ [Mech. Ageing Dev. 125 (2004) 629–632] Mechanisms of Ageing and Development. 127: 652. DOI: 10.1016/J.Mad.2006.02.002  0.349
2005 Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, ... Weindruch R, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (New York, N.Y.). 309: 481-4. PMID 16020738 DOI: 10.1126/Science.1112125  0.638
2005 Colman RJ, McKiernan SH, Aiken JM, Weindruch R. Muscle mass loss in Rhesus monkeys: age of onset. Experimental Gerontology. 40: 573-81. PMID 15985353 DOI: 10.1016/J.Exger.2005.05.001  0.384
2005 Costantini C, Weindruch R, Della Valle G, Puglielli L. A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging. The Biochemical Journal. 391: 59-67. PMID 15966860 DOI: 10.1042/Bj20050700  0.338
2005 Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME. Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria. American Journal of Physiology. Endocrinology and Metabolism. 289: E429-38. PMID 15886224 DOI: 10.1152/Ajpendo.00435.2004  0.388
2005 Hagopian K, Ramsey JJ, Weindruch R. Serine utilization in mouse liver: influence of caloric restriction and aging. Febs Letters. 579: 2009-13. PMID 15792811 DOI: 10.1016/J.Febslet.2005.02.062  0.437
2005 Hagopian K, Ramsey JJ, Weindruch R. Fructose metabolizing enzymes from mouse liver: influence of age and caloric restriction. Biochimica Et Biophysica Acta. 1721: 37-43. PMID 15652177 DOI: 10.1016/J.Bbagen.2004.10.001  0.439
2005 Harper ME, Bevilacqua L, Hagopian K, Weindruch R, Ramsey JJ. Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiologica Scandinavica. 182: 321-31. PMID 15569093 DOI: 10.1111/J.1365-201X.2004.01370.X  0.374
2005 Hagopian K, Harper ME, Ram JJ, Humble SJ, Weindruch R, Ramsey JJ. Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria. American Journal of Physiology. Endocrinology and Metabolism. 288: E674-84. PMID 15562252 DOI: 10.1152/Ajpendo.00382.2004  0.36
2004 Hagopian K, Ramsey JJ, Weindruch R. Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction. Experimental Gerontology. 39: 1145-54. PMID 15288689 DOI: 10.1016/J.Exger.2004.04.009  0.38
2004 Gonzalez AA, Kumar R, Mulligan JD, Davis AJ, Weindruch R, Saupe KW. Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity. American Journal of Physiology. Endocrinology and Metabolism. 287: E1032-7. PMID 15251868 DOI: 10.1152/Ajpendo.00172.2004  0.348
2004 Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA. Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice. Annals of the New York Academy of Sciences. 1019: 85-95. PMID 15246999 DOI: 10.1196/Annals.1297.017  0.686
2004 Butler RN, Sprott R, Warner H, Bland J, Feuers R, Forster M, Fillit H, Harman SM, Hewitt M, Hyman M, Johnson K, Kligman E, McClearn G, Nelson J, Richardson A, ... ... Weindruch R, et al. Biomarkers of aging: from primitive organisms to humans. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 59: B560-7. PMID 15215265 DOI: 10.1093/Gerona/59.6.B560  0.4
2004 Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R, Prolla TA. The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radical Biology & Medicine. 36: 1043-57. PMID 15059645 DOI: 10.1016/J.Freeradbiomed.2004.01.015  0.696
2004 Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME. Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. American Journal of Physiology. Endocrinology and Metabolism. 286: E852-61. PMID 14736705 DOI: 10.1152/Ajpendo.00367.2003  0.351
2004 Higami Y, Pugh TD, Page GP, Allison DB, Prolla TA, Weindruch R. Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 415-7. PMID 14688200 DOI: 10.1096/Fj.03-0678Fje  0.658
2004 Ramsey JJ, Hagopian K, Kenny TM, Koomson EK, Bevilacqua L, Weindruch R, Harper ME. Proton leak and hydrogen peroxide production in liver mitochondria from energy-restricted rats. American Journal of Physiology. Endocrinology and Metabolism. 286: E31-40. PMID 14662512 DOI: 10.1152/Ajpendo.00283.2003  0.338
2004 Gadbury GL, Page GP, Edwards J, Kayo T, Prolla TA, Weindruch R, Permana PA, Mountz JD, Allison DB. Power and sample size estimation in high dimensional biology Statistical Methods in Medical Research. 13: 325-338. DOI: 10.1191/0962280204Sm369Ra  0.548
2004 Higami Y, Weindruch R, Prolla TA, Shimokawa I. Altered lipid metabolism in rodents subjected to calorie restriction Geriatrics and Gerontology International. 4: S155-S157. DOI: 10.1111/J.1447-0594.2004.00185.X  0.553
2004 Gadbury GL, Page GP, Edwards J, Kayo T, Prolla TA, Weindruch R, Permana PA, Mountz JD, Allison DB. Power and sample size estimation in high dimensional biology Statistical Methods in Medical Research. 13: 325-338.  0.503
2003 Barger JL, Walford RL, Weindruch R. The retardation of aging by caloric restriction: its significance in the transgenic era. Experimental Gerontology. 38: 1343-51. PMID 14698815 DOI: 10.1016/J.Exger.2003.10.017  0.464
2003 Atwood CS, Barzilai N, Bowen RL, Brown-Borg HM, Jarrard DF, Fu VX, Heilbronn LK, Ingram DK, Ravussin E, Schwartz RS, Weindruch R. Pennington scientific symposium on mechanisms and retardation of aging. Experimental Gerontology. 38: 1217-26. PMID 14580876 DOI: 10.1016/J.Exger.2003.08.005  0.474
2003 Weindruch R. Caloric restriction, gene expression, and aging. Alzheimer Disease and Associated Disorders. 17: S58-9. PMID 12813211 DOI: 10.1097/00002093-200304002-00008  0.468
2003 Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA. Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart. Physiological Genomics. 13: 119-27. PMID 12595580 DOI: 10.1152/Physiolgenomics.00172.2002  0.687
2003 Hagopian K, Ramsey JJ, Weindruch R. Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver. Experimental Gerontology. 38: 267-78. PMID 12581790 DOI: 10.1016/S0531-5565(02)00202-4  0.364
2003 Hagopian K, Ramsey JJ, Weindruch R. Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice. Experimental Gerontology. 38: 253-66. PMID 12581789 DOI: 10.1016/S0531-5565(02)00203-6  0.381
2003 Blanc S, Schoeller D, Kemnitz J, Weindruch R, Colman R, Newton W, Wink K, Baum S, Ramsey J. Energy expenditure of rhesus monkeys subjected to 11 years of dietary restriction. The Journal of Clinical Endocrinology and Metabolism. 88: 16-23. PMID 12519821 DOI: 10.1210/Jc.2002-020405  0.311
2003 Bronikowski AM, Carter PA, Morgan TJ, Garland T, Ung N, Pugh TD, Weindruch R, Prolla TA. Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart. Physiological Genomics. 12: 129-38. PMID 12429864 DOI: 10.1152/Physiolgenomics.00082.2002  0.667
2003 Weindruch R. Caloric restriction: life span extension and retardation of brain aging Clinical Neuroscience Research. 2: 279-284. DOI: 10.1016/S1566-2772(03)00004-5  0.512
2002 Weindruch R, Kayo T, Lee CK, Prolla TA. Effects of caloric restriction on gene expression. Nestlé Nutrition Workshop Series. Clinical & Performance Programme. 6: 17-28; discussion 28. PMID 16969964  0.564
2002 Weindruch R, Prolla TA. Gene expression profile of the aging brain. Archives of Neurology. 59: 1712-4. PMID 12433256 DOI: 10.1001/Archneur.59.11.1712  0.644
2002 Lee CK, Allison DB, Brand J, Weindruch R, Prolla TA. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proceedings of the National Academy of Sciences of the United States of America. 99: 14988-93. PMID 12419851 DOI: 10.1073/Pnas.232308999  0.709
2002 Weindruch R, Kayo T, Lee CK, Prolla TA. Gene expression profiling of aging using DNA microarrays. Mechanisms of Ageing and Development. 123: 177-93. PMID 11718811 DOI: 10.1016/S0047-6374(01)00344-X  0.683
2002 Allison DB, Gadbury GL, Heo M, Fernández JR, Lee C, Prolla TA, Weindruch R. A mixture model approach for the analysis of microarray gene expression data Computational Statistics & Data Analysis. 39: 1-20. DOI: 10.1016/S0167-9473(01)00046-9  0.366
2001 Lee CK, Prolla TA, Weindruch R. Caloric Intake, Oxidative Stress and Aging. Thescientificworldjournal. 1: 85. PMID 30147557 DOI: 10.1100/Tsw.2001.117  0.724
2001 Weindruch R, Keenan KP, Carney JM, Fernandes G, Feuers RJ, Floyd RA, Halter JB, Ramsey JJ, Richardson A, Roth GS, Spindler SR. Caloric restriction mimetics: metabolic interventions. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 56: 20-33. PMID 12088209 DOI: 10.1093/Gerona/56.Suppl_1.20  0.379
2001 Edwards IJ, Rudel LL, Terry JG, Kemnitz JW, Weindruch R, Zaccaro DJ, Cefalu WT. Caloric restriction lowers plasma lipoprotein (a) in male but not female rhesus monkeys. Experimental Gerontology. 36: 1413-8. PMID 11602214 DOI: 10.1016/S0531-5565(01)00107-3  0.31
2001 Prolla TA, Allison DB, Weindruch R. Response to "Interpretation, design, and analysis of gene array expression experiments". The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 56: B327-30. PMID 11487590 DOI: 10.1093/GERONA/56.8.B327  0.532
2001 Kayo T, Allison DB, Weindruch R, Prolla TA. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proceedings of the National Academy of Sciences of the United States of America. 98: 5093-8. PMID 11309484 DOI: 10.1073/Pnas.081061898  0.712
2001 Weindruch R, Kayo T, Lee CK, Prolla TA. Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice. The Journal of Nutrition. 131: 918S-923S. PMID 11238786 DOI: 10.1093/Jn/131.3.918S  0.716
2001 Ramsey JJ, Harper ME, Weindruch R. Restriction of energy intake, energy expenditure, and aging. Free Radical Biology & Medicine. 29: 946-68. PMID 11084284 DOI: 10.1016/S0891-5849(00)00417-2  0.322
2000 Ramsey JJ, Colman RJ, Binkley NC, Christensen JD, Gresl TA, Kemnitz JW, Weindruch R. Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. Experimental Gerontology. 35: 1131-49. PMID 11113597 DOI: 10.1016/S0531-5565(00)00166-2  0.416
2000 Zainal TA, Oberley TD, Allison DB, Szweda LI, Weindruch R. Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle Faseb Journal. 14: 1825-1836. PMID 10973932 DOI: 10.1096/Fj.99-0881Com  0.395
2000 Cefalu WT, Terry JG, Thomas MJ, Morgan TM, Edwards IJ, Rudel LL, Kemnitz JW, Weindruch R. In vitro oxidation of low-density lipoprotein in two species of nonhuman primates subjected to caloric restriction. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 55: B355-61. PMID 10898249 DOI: 10.1093/Gerona/55.7.B355  0.336
2000 Lopez ME, Van Zeeland NL, Dahl DB, Weindruch R, Aiken JM. Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutation Research. 452: 123-38. PMID 10894897 DOI: 10.1016/S0027-5107(00)00059-2  0.324
2000 Lee CK, Weindruch R, Prolla TA. Gene-expression profile of the ageing brain in mice. Nature Genetics. 25: 294-7. PMID 10888876 DOI: 10.1038/77046  0.67
2000 Hall DM, Oberley TD, Moseley PM, Buettner GR, Oberley LW, Weindruch R, Kregel KC. Caloric restriction improves thermotolerance and reduces hyperthermia- induced cellular damage in old rats Faseb Journal. 14: 78-86. PMID 10627282 DOI: 10.1096/Fasebj.14.1.78  0.333
1999 Cefalu WT, Wagner JD, Bell-Farrow AD, Edwards IJ, Terry JG, Weindruch R, Kemnitz JW. Influence of caloric restriction on the development of atherosclerosis in nonhuman primates: progress to date. Toxicological Sciences : An Official Journal of the Society of Toxicology. 52: 49-55. PMID 10630590 DOI: 10.1093/Toxsci/52.2.49  0.358
1999 Wanagat J, Allison DB, Weindruch R. Caloric intake and aging: Mechanisms in rodents and a study in nonhuman primates Toxicological Sciences. 52: 35-40. PMID 10630588 DOI: 10.1093/Toxsci/52.Suppl_1.35  0.442
1999 Pugh TD, Klopp RG, Weindruch R. Controlling caloric consumption: protocols for rodents and rhesus monkeys. Neurobiology of Aging. 20: 157-65. PMID 10537025 DOI: 10.1016/S0197-4580(99)00043-3  0.434
1999 Lee CK, Klopp RG, Weindruch R, Prolla TA. Gene expression profile of aging and its retardation by caloric restriction. Science (New York, N.Y.). 285: 1390-3. PMID 10464095 DOI: 10.1126/Science.285.5432.1390  0.7
1998 Lee CM, Aspnes LE, Chung SS, Weindruch R, Aiken JM. Influences of caloric restriction on age-associated skeletal muscle fiber characteristics and mitochondrial changes in rats and mice. Annals of the New York Academy of Sciences. 854: 182-91. PMID 9928429 DOI: 10.1111/J.1749-6632.1998.Tb09901.X  0.354
1998 Lass A, Sohal BH, Weindruch R, Forster MJ, Sohal RS. Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria Free Radical Biology and Medicine. 25: 1089-1097. PMID 9870563 DOI: 10.1016/S0891-5849(98)00144-0  0.417
1998 Lee CM, Lopez ME, Weindruch R, Aiken JM. Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radical Biology & Medicine. 25: 964-72. PMID 9840742 DOI: 10.1016/S0891-5849(98)00185-3  0.306
1998 Edwards IJ, Rudel LL, Terry JG, Kemnitz JW, Weindruch R, Cefalu WT. Caloric restriction in rhesus monkeys reduces low density lipoprotein interaction with arterial proteoglycans. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 53: B443-8. PMID 9823741 DOI: 10.1093/Gerona/53A.6.B443  0.342
1998 Schwarze SR, Weindruch R, Aiken JM. Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radical Biology & Medicine. 25: 740-7. PMID 9801075 DOI: 10.1016/S0891-5849(98)00153-1  0.366
1998 Schwarze SR, Weindruch R, Aiken JM. Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster. Mutation Research. 382: 99-107. PMID 9691990 DOI: 10.1016/S1383-5726(97)00013-7  0.396
1998 Harper ME, Monemdjou S, Ramsey JJ, Weindruch R. Age-related increase in mitochondrial proton leak and decrease in ATP turnover reactions in mouse hepatocytes. The American Journal of Physiology. 275: E197-206. PMID 9688619 DOI: 10.1152/Ajpendo.1998.275.2.E197  0.339
1998 Weindruch R, Lane MA, Ingram DK, Ershler WB, Roth GS. Dietary restriction in rhesus monkeys: lymphopenia and reduced mitogen-induced proliferation in peripheral blood mononuclear cells. Aging (Milan, Italy). 9: 304-8. PMID 9359942 DOI: 10.1007/Bf03341833  0.356
1997 Kim MJ, Aiken JM, Havighurst T, Hollander J, Ripple MO, Weindruch R. Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. The Journal of Nutrition. 127: 2293-301. PMID 9405577 DOI: 10.1093/Jn/127.12.2293  0.321
1997 Suzuki K, Oberley TD, Pugh TD, Sempf JM, Weindruch R. Caloric restriction diminishes the age-associated loss of immunoreactive catalase in rat prostate. The Prostate. 33: 256-63. PMID 9397198 DOI: 10.1002/(Sici)1097-0045(19971201)33:4<256::Aid-Pros6>3.0.Co;2-F  0.445
1997 Aspnes LE, Lee CM, Weindruch R, Chung SS, Roecker EB, Aiken JM. Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 11: 573-81. PMID 9212081 DOI: 10.1096/Fasebj.11.7.9212081  0.358
1997 Ramsey JJ, Roecker EB, Weindruch R, Kemnitz JW. Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction. The American Journal of Physiology. 272: E901-7. PMID 9176192 DOI: 10.1152/Ajpendo.1997.272.5.E901  0.323
1997 Lee CM, Weindruch R, Aiken JM. Age-associated alterations of the mitochondrial genome. Free Radical Biology & Medicine. 22: 1259-69. PMID 9098100 DOI: 10.1016/S0891-5849(96)00546-1  0.388
1997 Sanderson JP, Binkley N, Roecker EB, Champ JE, Pugh TD, Aspnes L, Weindruch R. Influence of fat intake and caloric restriction on bone in aging male rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 52: B20-5. PMID 9008654 DOI: 10.1093/Gerona/52A.1.B20  0.357
1997 Aspnes LE, Kim M, Weindruch R. Dietary Restriction, Aging and Disease Prevention: A Discussion of Human Application Topics in Clinical Nutrition. 12: 76-83. DOI: 10.1097/00008486-199712030-00013  0.362
1996 Weindruch R. The retardation of aging by caloric restriction: studies in rodents and primates. Toxicologic Pathology. 24: 742-745. PMID 8994305 DOI: 10.1177/019262339602400618  0.472
1996 Eimon PM, Chung SS, Lee CM, Weindruch R, Aiken JM. Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. Developmental Genetics. 18: 107-13. PMID 8934872 DOI: 10.1002/(Sici)1520-6408(1996)18:2<107::Aid-Dvg3>3.0.Co;2-D  0.381
1996 Desai VG, Weindruch R, Hart RW, Feuers RJ. Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice. Archives of Biochemistry and Biophysics. 333: 145-51. PMID 8806765 DOI: 10.1006/Abbi.1996.0375  0.401
1996 Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science (New York, N.Y.). 273: 59-63. PMID 8658196 DOI: 10.1126/Science.273.5271.59  0.372
1996 Lane MA, Baer DJ, Rumpler WV, Weindruch R, Ingram DK, Tilmont EM, Cutler RG, Roth GS. Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proceedings of the National Academy of Sciences of the United States of America. 93: 4159-64. PMID 8633033 DOI: 10.1073/Pnas.93.9.4159  0.421
1996 Weindruch R. Caloric restriction and aging. Scientific American. 274: 46-52. PMID 8533065 DOI: 10.1038/Scientificamerican0196-46  0.34
1996 Chung SS, Eimon PM, Weindruch R, Aiken JM. Analysis of age-associated mitochondrial DNA deletion breakpoint regions from mice suggests a novel model of deletion formation Journal of the American Aging Association. 19: 117-128. DOI: 10.1007/Bf02434081  0.339
1995 Weindruch R, Marriott BM, Conway J, Knapka JJ, Lane MA, Cutler RG, Roth GS, Ingram DK. Measures of body size and growth in rhesus and squirrel monkeys subjected to long-term dietary restriction. American Journal of Primatology. 35: 207-228. PMID 31924069 DOI: 10.1002/Ajp.1350350304  0.388
1995 Schwarze SR, Lee CM, Chung SS, Roecker EB, Weindruch R, Aiken JM. High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mechanisms of Ageing and Development. 83: 91-101. PMID 8569289 DOI: 10.1016/0047-6374(95)01611-3  0.348
1995 Weindruch R, May PC. Use of Caloric Restriction to Investigate Neuroendocrine Involvement in Aging Neurobiology of Aging. 16: 845-847. PMID 8532120 DOI: 10.1016/0197-4580(95)00067-O  0.422
1995 Weindruch R. Interventions based on the possibility that oxidative stress contributes to sarcopenia. Journals of Gerontology Series a-Biological Sciences and Medical Sciences. 50: 157-161. PMID 7493211 DOI: 10.1093/Gerona/50A.Special_Issue.157  0.372
1995 Weindruch R. Modulation of aging processes by dietary restriction: by B.P. Yu, CRC Press, Boca Raton, 1994, 294 pages, ISBN 0 8493 4994X, $181.95 Experimental Gerontology. 30: 661-663. DOI: 10.1016/0531-5565(95)90012-8  0.314
1994 Lee CM, Eimon P, Weindruch R, Aiken JM. Direct repeat sequences are not required at the breakpoints of age-associated mitochondrial DNA deletions in rhesus monkeys. Mechanisms of Ageing and Development. 75: 69-79. PMID 9128755 DOI: 10.1016/0047-6374(94)90029-9  0.379
1994 Kim MJ, Roecker EB, Weindruch R. Influences of aging and dietary restriction on red blood cell density profiles and antioxidant enzyme activities in rhesus monkeys. Experimental Gerontology. 28: 515-27. PMID 8137888 DOI: 10.1016/0531-5565(93)90040-K  0.394
1994 Luhtala TA, Roecker EB, Pugh T, Feuers RJ, Weindruch R. Dietary restriction attenuates age-related increases in rat skeletal muscle antioxidant enzyme activities. Journal of Gerontology. 49: B231-8. PMID 8056935 DOI: 10.1093/Geronj/49.5.B231  0.406
1994 Chung SS, Weindruch R, Schwarze SR, McKenzie DI, Aiken JM. Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging (Milan, Italy). 6: 193-200. PMID 7993927 DOI: 10.1007/Bf03324239  0.457
1994 Feuers RJ, Weindruch R, Hart RW. Caloric restriction, aging, and antioxidant enzymes. Mutation Research. 295: 191-200. PMID 7507557 DOI: 10.1016/0921-8734(93)90020-4  0.421
1993 Kemnitz JW, Weindruch R, Roecker EB, Crawford K, Kaufman PL, Ershler WB. Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. Journal of Gerontology. 48: B17-26. PMID 8418134 DOI: 10.1093/Geronj/48.1.B17  0.359
1993 Lee CM, Chung SS, Kaczkowski JM, Weindruch R, Aiken JM. Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys Journals of Gerontology. 48. PMID 8227987 DOI: 10.1093/Geronj/48.6.B201  0.411
1992 Koizumi A, Tsukada M, Wada Y, Masuda H, Weindruch R. Mitotic activity in mice is suppressed by energy restriction-induced torpor. The Journal of Nutrition. 122: 1446-53. PMID 1619471 DOI: 10.1093/Jn/122.7.1446  0.339
1992 Weindruch R. Effect of caloric restriction on age-associated cancers. Experimental Gerontology. 27: 575-581. PMID 1426090 DOI: 10.1016/0531-5565(92)90012-O  0.413
1991 Effros RB, Walford RL, Weindruch R, Mitcheltree C. Influences of dietary restriction on immunity to influenza in aged mice. Journal of Gerontology. 46: B142-7. PMID 2071828 DOI: 10.1093/Geronj/46.4.B142  0.359
1991 Weindruch R, Masoro EJ. Concerns about rodent models for aging research. Journal of Gerontology. 46: B87-8. PMID 2030267 DOI: 10.1093/Geronj/46.3.B87  0.345
1991 Weindruch R, Albanes D, Kritchevsky D. The role of calories and caloric restriction in carcinogenesis. Hematology-Oncology Clinics of North America. 5: 79-89. DOI: 10.1016/S0889-8588(18)30455-6  0.36
1990 Ingram DK, Cutler RG, Weindruch R, Renquist DM, Knapka JJ, April M, Belcher CT, Clark MA, Hatcherson CD, Marriott BM. Dietary restriction and aging: the initiation of a primate study. Journal of Gerontology. 45: B148-63. PMID 2394908 DOI: 10.1093/Geronj/45.5.B148  0.38
1990 Koizumi A, Wada Y, Tsukada M, Kamiyama S, Weindruch R. Effects of energy restriction on mouse mammary tumor virus mRNA levels in mammary glands and uterus and on uterine endometrial hyperplasia and pituitary histology in C3H/SHN F1 mice. The Journal of Nutrition. 120: 1401-11. PMID 2172493 DOI: 10.1093/Jn/120.11.1401  0.345
1989 Weindruch R. Dietary restriction, tumors, and aging in rodents. Journal of Gerontology. 44: 67-71. PMID 2681366 DOI: 10.1093/Geronj/44.6.67  0.369
1987 Ingram DK, Weindruch R, Spangler EL, Freeman JR, Walford RL. Dietary restriction benefits learning and motor performance of aged mice. Journal of Gerontology. 42: 78-81. PMID 3794202 DOI: 10.1093/geronj/42.1.78  0.329
1982 Weindruch R, Walford RL. Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science (New York, N.Y.). 215: 1415-8. PMID 7063854 DOI: 10.1126/Science.7063854  0.423
1982 Weindruch R, Gottesman SR, Walford RL. Modification of age-related immune decline in mice dietarily restricted from or after midadulthood. Proceedings of the National Academy of Sciences of the United States of America. 79: 898-902. PMID 6977776 DOI: 10.1073/pnas.79.3.898  0.331
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