Daniel Gaudet - Publications

Affiliations: 
Universite Laval (Canada) 
Area:
Genetics, Pathology, Public Health

174 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Aljenedil S, Alothman L, Bélanger AM, Brown L, Lahijanian Z, Bergeron J, Couture P, Baass A, Ruel I, Brisson D, Khoury E, Gaudet D, Genest J. Lomitapide for treatment of homozygous familial hypercholesterolemia: The Québec experience. Atherosclerosis. 310: 54-63. PMID 32906018 DOI: 10.1016/j.atherosclerosis.2020.07.028  1
2020 Santos RD, Ruzza A, Hovingh GK, Wiegman A, Mach F, Kurtz CE, Hamer A, Bridges I, Bartuli A, Bergeron J, Szamosi T, Santra S, Stefanutti C, Descamps OS, Greber-Platzer S, ... ... Gaudet D, et al. Evolocumab in Pediatric Heterozygous Familial Hypercholesterolemia. The New England Journal of Medicine. PMID 32865373 DOI: 10.1056/NEJMoa2019910  0.36
2020 Raal FJ, Rosenson RS, Reeskamp LF, Hovingh GK, Kastelein JJP, Rubba P, Ali S, Banerjee P, Chan KC, Gipe DA, Khilla N, Pordy R, Weinreich DM, Yancopoulos GD, Zhang Y, ... Gaudet D, et al. Evinacumab for Homozygous Familial Hypercholesterolemia. The New England Journal of Medicine. 383: 711-720. PMID 32813947 DOI: 10.1056/NEJMoa2004215  0.36
2020 Tremblay K, Brisson D, Gaudet D. Gene expression profiles of recurrent acute pancreatitis risk in patients with sustained chylomicronemia. Endocrine Journal. PMID 32727960 DOI: 10.1507/endocrj.EJ20-0123  1
2020 Tremblay K, Gaudet D, Khoury E, Brisson D. Dissection of Clinical and Gene Expression Signatures of Familial versus Multifactorial Chylomicronemia. Journal of the Endocrine Society. 4: bvaa056. PMID 32537545 DOI: 10.1210/jendso/bvaa056  1
2020 Roy N, Gaudet D, Tremblay G, Brisson D. Association of common gene-smoking interactions with elevated plasma apolipoprotein B concentration. Lipids in Health and Disease. 19: 98. PMID 32430061 DOI: 10.1186/s12944-020-01287-7  1
2020 Sun CJ, McCudden C, Brisson D, Shaw J, Gaudet D, Ooi TC. Calculated Non-HDL Cholesterol Includes Cholesterol in Larger Triglyceride-Rich Lipoproteins in Hypertriglyceridemia. Journal of the Endocrine Society. 4: bvz010. PMID 32010872 DOI: 10.1210/jendso/bvz010  1
2020 Khoury E, Brisson D, Gaudet D. Preclinical discovery and development of evolocumab for the treatment of hypercholesterolemia. Expert Opinion On Drug Discovery. 1-12. PMID 31973581 DOI: 10.1080/17460441.2020.1704728  1
2019 Guay SP, Houde AA, Breton E, Baillargeon JP, Perron P, Gaudet D, Hivert MF, Brisson D, Bouchard L. DNA methylation at gene locus mediates the association between maternal total cholesterol changes in pregnancy and cord blood leptin levels. Journal of Developmental Origins of Health and Disease. 1-10. PMID 31753053 DOI: 10.1017/S204017441900076X  1
2019 Gaudet D, Durst R, Lepor N, Bakker-Arkema R, Bisgaier C, Masson L, Golden L, Kastelein JJ, Hegele RA, Stein E. Usefulness of Gemcabene in Homozygous Familial Hypercholesterolemia (from COBALT-1). The American Journal of Cardiology. PMID 31685212 DOI: 10.1016/j.amjcard.2019.09.010  0.36
2019 Hegele RA, Borén J, Ginsberg HN, Arca M, Averna M, Binder CJ, Calabresi L, Chapman MJ, Cuchel M, von Eckardstein A, Frikke-Schmidt R, Gaudet D, Hovingh GK, Kronenberg F, Lütjohann D, et al. Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement. The Lancet. Diabetes & Endocrinology. PMID 31582260 DOI: 10.1016/S2213-8587(19)30264-5  0.36
2019 Floyd JS, Bloch KM, Brody JA, Maroteau C, Siddiqui MK, Gregory R, Carr DF, Molokhia M, Liu X, Bis JC, Ahmed A, Liu X, Hallberg P, Yue QY, Magnusson PKE, ... ... Gaudet D, et al. Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing. Plos One. 14: e0218115. PMID 31242253 DOI: 10.1371/journal.pone.0218115  1
2019 Khoury E, Brisson D, Roy N, Tremblay G, Gaudet D. Review of the long-term safety of lomitapide: a microsomal triglycerides transfer protein inhibitor for treating homozygous familial hypercholesterolemia. Expert Opinion On Drug Safety. PMID 30945578 DOI: 10.1080/14740338.2019.1602606  1
2018 Brunham LR, Ruel I, Aljenedil S, Rivière JB, Baass A, Tu JV, Mancini GBJ, Raggi P, Gupta M, Couture P, Pearson GJ, Bergeron J, Francis GA, McCrindle BW, Morrison K, ... ... Gaudet D, et al. Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018. The Canadian Journal of Cardiology. 34: 1553-1563. PMID 30527143 DOI: 10.1016/j.cjca.2018.09.005  0.56
2018 Brunham LR, Ruel I, Khoury E, Hegele RA, Couture P, Bergeron J, Baass A, Dufour R, Francis GA, Cermakova L, Mancini GBJ, Brophy JM, Brisson D, Gaudet D, Genest J. Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry. Atherosclerosis. 277: 419-424. PMID 30270080 DOI: 10.1016/j.atherosclerosis.2018.05.040  1
2018 Tremblay M, Brisson D, Gaudet D. Association study between a polymorphic poly-T repeat sequence in the promoter of the somatostatin gene and metabolic syndrome. Bmc Medical Genetics. 19: 130. PMID 30053852 DOI: 10.1186/s12881-018-0641-6  1
2018 Dron JS, Wang J, Berberich AJ, Iacocca MA, Cao H, Yang P, Knoll J, Tremblay K, Brisson D, Netzer C, Gouni-Berthold I, Gaudet D, Hegele RA. Large-scale deletions of the ABCA1 gene in patients with hypoalphalipoproteinemia. Journal of Lipid Research. PMID 29866657 DOI: 10.1194/jlr.P086280  1
2018 Kusters DM, Braamskamp MJAM, Langslet G, McCrindle BW, Cassiman D, Francis GA, Gagne C, Gaudet D, Morrison KM, Wiegman A, Turner T, Miller E, Raichlen J, Martin PD, Stein EA, et al. Response by Kusters et al to Letter Regarding Article, "Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label)". Circulation. 137: 641-642. PMID 29431667 DOI: 10.1161/CIRCULATIONAHA.117.031676  0.36
2017 Gaudet D, Gipe D, Hovingh K, Ahmad Z, Cuchel M, Shah P, Chyu KY, Pordy R, Sasiela W, Chan KC, Khoury E. Safety and efficacy of evinacumab, a monoclonal antibody to ANGPTL3, in patients with homozygous familial hypercholesterolemia: a single-arm, open-label, proof-of-concept study. Atherosclerosis. 263: e9. PMID 29366264 DOI: 10.1016/j.atherosclerosis.2017.06.057  0.64
2017 Tremblay K, Brisson D, Gaudet D. Natural history and gene expression signature of platelet count in lipoprotein lipase deficiency. Atherosclerosis. 263: e100. PMID 29365429 DOI: 10.1016/j.atherosclerosis.2017.06.325  1
2017 Ruel I, Aljenedil S, Sadri I, de Varennes É, Hegele RA, Couture P, Bergeron J, Wanneh E, Baass A, Dufour R, Gaudet D, Brisson D, Brunham LR, Francis GA, Cermakova L, et al. Imputation of Baseline LDL Cholesterol Concentration in Patients with Familial Hypercholesterolemia on Statins or Ezetimibe. Clinical Chemistry. PMID 29038147 DOI: 10.1373/clinchem.2017.279422  1
2017 Paquette M, Brisson D, Dufour R, Khoury É, Gaudet D, Baass A. Cardiovascular disease in familial hypercholesterolemia: Validation and refinement of the Montreal-FH-SCORE. Journal of Clinical Lipidology. PMID 28801029 DOI: 10.1016/j.jacl.2017.07.008  1
2017 Gaudet D, Gipe DA, Pordy R, Ahmad Z, Cuchel M, Shah PK, Chyu KY, Sasiela WJ, Chan KC, Brisson D, Khoury E, Banerjee P, Gusarova V, Gromada J, Stahl N, et al. ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia. The New England Journal of Medicine. 377: 296-297. PMID 28723334 DOI: 10.1056/NEJMc1705994  1
2017 Braamskamp MJAM, Langslet G, McCrindle BW, Cassiman DM, Francis GA, Gagne C, Gaudet D, Morrison KM, Wiegman A, Turner T, Miller E, Kusters DM, Raichlen JS, Martin PD, Stein EA, et al. Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children with Heterozygous Familial Hypercholesterolemia: The CHARON Study. Circulation. PMID 28592434 DOI: 10.1161/CIRCULATIONAHA.116.025158  0.36
2017 Gagné-Ouellet V, Houde AA, Guay SP, Perron P, Gaudet D, Guérin R, Baillargeon JP, Hivert MF, Brisson D, Bouchard L. Placental lipoprotein lipase DNA methylation alterations are associated with gestational diabetes and body composition at 5 years of age. Epigenetics. 0. PMID 28486003 DOI: 10.1080/15592294.2017.1322254  1
2016 Dufour R, Bergeron J, Gaudet D, Weiss R, Hovingh GK, Qing Z, Yang F, Andisik M, Torri A, Pordy R, Gipe DA. Open-label therapy with alirocumab in patients with heterozygous familial hypercholesterolemia: Results from three years of treatment. International Journal of Cardiology. 228: 754-760. PMID 27886619 DOI: 10.1016/j.ijcard.2016.11.046  0.36
2016 Gaudet D, Stroes ES, Methot J, Brisson D, Tremblay K, Bernelot Moens SJ, Iotti G, Rastelletti I, Ardigo D, Corzo D, Meyer C, Andersen M, Ruszniewski P, Deakin M, Bruno MJ. A Long-Term (up to 6 years) Retrospective Analysis of Gene Therapy with Alipogene Tiparvovec and its Effect on Lipoprotein Lipase Deficiency (LPLD)-Induced Pancreatitis. Human Gene Therapy. PMID 27412455 DOI: 10.1089/hum.2015.158  1
2016 Côté S, Gagné-Ouellet V, Guay SP, Allard C, Houde AA, Perron P, Baillargeon JP, Gaudet D, Guérin R, Brisson D, Hivert MF, Bouchard L. PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns. Clinical Epigenetics. 8: 72. PMID 27340502 DOI: 10.1186/s13148-016-0239-9  1
2016 Besseling J, Reitsma JB, Gaudet D, Brisson D, Kastelein JJ, Hovingh GK, Hutten BA. Selection of individuals for genetic testing for familial hypercholesterolaemia: development and external validation of a prediction model for the presence of a mutation causing familial hypercholesterolaemia. European Heart Journal. PMID 27044878 DOI: 10.1093/eurheartj/ehw135  1
2016 Guay SP, Légaré C, Brisson D, Mathieu P, Bossé Y, Gaudet D, Bouchard L. Epigenetic and genetic variations at the TNNT1 gene locus are associated with HDL-C levels and coronary artery disease. Epigenomics. 8: 359-71. PMID 26950807 DOI: 10.2217/epi.15.120  1
2016 Tremblay M, Brisson D, Gaudet D. Association between a polymorphic poly-T repeat sequence in the promoter of the somatostatin gene and hypertension. Hypertension Research : Official Journal of the Japanese Society of Hypertension. 39: 467-74. PMID 26818653 DOI: 10.1038/hr.2016.4  1
2015 Gaudet D, Brisson D. Gene-based therapies in lipidology: current status and future challenges. Current Opinion in Lipidology. 26: 553-65. PMID 26780008 DOI: 10.1097/MOL.0000000000000240  1
2015 Braamskamp MJ, Langslet G, McCrindle BW, Cassiman D, Francis GA, Gagné C, Gaudet D, Morrison KM, Wiegman A, Turner T, Kusters DM, Miller E, Raichlen JS, Wissmar J, Martin PD, et al. Efficacy and safety of rosuvastatin therapy in children and adolescents with familial hypercholesterolemia: Results from the CHARON study. Journal of Clinical Lipidology. 9: 741-50. PMID 26687694 DOI: 10.1016/j.jacl.2015.07.011  0.36
2015 Goodwin K, Abrahamowicz M, Leonard G, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. Dietary Vitamin A and Visceral Adiposity: A Modulating Role of the Retinol-Binding Protein 4 Gene. Journal of Nutrigenetics and Nutrigenomics. 8: 164-173. PMID 26667887 DOI: 10.1159/000442090  0.92
2015 Villeneuve S, Brisson D, Gaudet D. Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality. Journal of Lipids. 2015: 742408. PMID 26605088 DOI: 10.1155/2015/742408  1
2015 Houde AA, Ruchat SM, Allard C, Baillargeon JP, St-Pierre J, Perron P, Gaudet D, Brisson D, Hivert MF, Bouchard L. LRP1B, BRD2 and CACNA1D: new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia. Epigenomics. PMID 26586120 DOI: 10.2217/epi.15.72  0.92
2015 Lachaine J, Gaudet D, Miron A, Tremblay K. Hospitalizations In Hyperchylomicronemia Patients In Quebec, Canada; Results From A Real-World Observational Study. Value in Health : the Journal of the International Society For Pharmacoeconomics and Outcomes Research. 18: A679. PMID 26533807 DOI: 10.1016/j.jval.2015.09.2018  0.72
2015 Gaudet D, Alexander VJ, Baker BF, Brisson D, Tremblay K, Singleton W, Geary RS, Hughes SG, Viney NJ, Graham MJ, Crooke RM, Witztum JL, Brunzell JD, Kastelein JJ. Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. The New England Journal of Medicine. 373: 438-47. PMID 26222559 DOI: 10.1056/NEJMoa1400283  0.92
2015 Shin J, Bourdon C, Bernard M, Wilson MD, Reischl E, Waldenberger M, Ruggeri B, Schumann G, Desrivieres S, Leemans A, Abrahamowicz M, Leonard G, Richer L, ... ... Gaudet D, et al. Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals. Human Molecular Genetics. 24: 5733-45. PMID 26220975 DOI: 10.1093/hmg/ddv294  0.92
2015 Bays H, Gaudet D, Weiss R, Ruiz JL, Watts GF, Gouni-Berthold I, Robinson J, Zhao J, Hanotin C, Donahue S. Alirocumab as Add-on To Atorvastatin Versus Other Lipid Treatment Strategies: ODYSSEY OPTIONS I Randomized Trial. The Journal of Clinical Endocrinology and Metabolism. jc20151520. PMID 26030325 DOI: 10.1210/jc.2015-1520  0.92
2015 Hovingh GK, Smits LP, Stefanutti C, Soran H, Kwok S, de Graaf J, Gaudet D, Keyserling CH, Klepp H, Frick J, Paolini JF, Dasseux JL, Kastelein JJ, Stroes ES. The effect of an apolipoprotein A-I-containing high-density lipoprotein-mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia: The Modifying Orphan Disease Evaluation (MODE) study. American Heart Journal. 169: 736-742.e1. PMID 25965722 DOI: 10.1016/j.ahj.2015.01.008  0.92
2015 El-Bikai R, Tahir MR, Tremblay J, Joffres M, Šeda O, Šedová L, Awadalla P, Laberge C, Knoppers BM, Dumas P, Gaudet D, Ste-Marie LG, Hamet P. Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals. Journal of Hypertension. 33: 727-35; discussion 7. PMID 25915877 DOI: 10.1097/HJH.0000000000000475  0.92
2015 Stefanutti C, Blom DJ, Averna MR, Meagher EA, Theron Hd, Marais AD, Hegele RA, Sirtori CR, Shah PK, Gaudet D, Vigna GB, Sachais BS, Di Giacomo S, du Plessis AM, Bloedon LT, et al. The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - a post-hoc analysis of a Phase 3, single-arm, open-label trial. Atherosclerosis. 240: 408-14. PMID 25897792 DOI: 10.1016/j.atherosclerosis.2015.03.014  0.92
2015 Meyers CD, Tremblay K, Amer A, Chen J, Jiang L, Gaudet D. Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndrome. Lipids in Health and Disease. 14: 8. PMID 25889044 DOI: 10.1186/s12944-015-0006-5  0.92
2015 Van Woudenberg M, Shin J, Bernard M, Syme C, Abrahamowicz M, Leonard G, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence. International Journal of Hypertension. 2015: 734586. PMID 25692033 DOI: 10.1155/2015/734586  0.92
2015 Guay SP, Brisson D, Mathieu P, Bossé Y, Gaudet D, Bouchard L. A study in familial hypercholesterolemia suggests reduced methylomic plasticity in men with coronary artery disease. Epigenomics. 7: 17-34. PMID 25687463 DOI: 10.2217/epi.14.64  0.92
2015 Lee KW, Richmond R, Hu P, French L, Shin J, Bourdon C, Reischl E, Waldenberger M, Zeilinger S, Gaunt T, McArdle W, Ring S, Woodward G, Bouchard L, Gaudet D, et al. Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age. Environmental Health Perspectives. 123: 193-9. PMID 25325234 DOI: 10.1289/ehp.1408614  0.92
2015 Raal FJ, Stein EA, Dufour R, Turner T, Civeira F, Burgess L, Langslet G, Scott R, Olsson AG, Sullivan D, Hovingh GK, Cariou B, Gouni-Berthold I, Somaratne R, Bridges I, ... ... Gaudet D, et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet. 385: 331-40. PMID 25282519 DOI: 10.1016/S0140-6736(14)61399-4  0.92
2015 Lee KW, Abrahamowicz M, Leonard GT, Richer L, Perron M, Veillette S, Reischl E, Bouchard L, Gaudet D, Paus T, Pausova Z. Prenatal exposure to cigarette smoke interacts with OPRM1 to modulate dietary preference for fat. Journal of Psychiatry & Neuroscience : Jpn. 40: 38-45. PMID 25266401 DOI: 10.1503/jpn.130263  0.92
2015 Gaudet D, Brisson D. Gene-based therapies in lipidology: Current status and future challenges Current Opinion in Lipidology. 26: 553-565. DOI: 10.1097/MOL.0000000000000240  0.92
2014 Gaudet D, Brisson D, Tremblay K, Alexander VJ, Singleton W, Hughes SG, Geary RS, Baker BF, Graham MJ, Crooke RM, Witztum JL. Targeting APOC3 in the familial chylomicronemia syndrome. The New England Journal of Medicine. 371: 2200-6. PMID 25470695 DOI: 10.1056/NEJMoa1400284  0.92
2014 Genest J, Hegele RA, Bergeron J, Brophy J, Carpentier A, Couture P, Davignon J, Dufour R, Frohlich J, Gaudet D, Gupta M, Krisnamoorthy P, Mancini J, McCrindle B, et al. Canadian Cardiovascular Society position statement on familial hypercholesterolemia. The Canadian Journal of Cardiology. 30: 1471-81. PMID 25448461 DOI: 10.1016/j.cjca.2014.09.028  0.92
2014 Villeneuve S, Brisson D, Marchant NL, Gaudet D. The potential applications of Apolipoprotein E in personalized medicine. Frontiers in Aging Neuroscience. 6: 154. PMID 25071563 DOI: 10.3389/fnagi.2014.00154  0.92
2014 Gaudet D, Kereiakes DJ, McKenney JM, Roth EM, Hanotin C, Gipe D, Du Y, Ferrand AC, Ginsberg HN, Stein EA. Effect of alirocumab, a monoclonal proprotein convertase subtilisin/kexin 9 antibody, on lipoprotein(a) concentrations (a pooled analysis of 150 mg every two weeks dosing from phase 2 trials). The American Journal of Cardiology. 114: 711-5. PMID 25060413 DOI: 10.1016/j.amjcard.2014.05.060  0.92
2014 Kaeppel C, Beattie SG, Fronza R, Van Logtenstein R, Salmon F, Schmidt S, Wolf S, Nowrouzi A, Glimm H, Von Kalle C, Petry H, Gaudet D, Schmidt M. Reply to: NGS library preparation may generate artifactual integration sites of AAV vectors Nature Medicine. 20: 578-579. PMID 24901561 DOI: 10.1038/nm.3584  0.92
2014 Desgagné V, Hivert MF, St-Pierre J, Guay SP, Baillargeon JP, Perron P, Gaudet D, Brisson D, Bouchard L. Epigenetic dysregulation of the IGF system in placenta of newborns exposed to maternal impaired glucose tolerance. Epigenomics. 6: 193-207. PMID 24811788 DOI: 10.2217/epi.14.3  0.92
2014 Tremblay K, Dubois-Bouchard C, Brisson D, Gaudet D. Association of CTRC and SPINK1 gene variants with recurrent hospitalizations for pancreatitis or acute abdominal pain in lipoprotein lipase deficiency. Frontiers in Genetics. 5: 90. PMID 24795752 DOI: 10.3389/fgene.2014.00090  0.92
2014 Guay SP, Brisson D, Lamarche B, Biron S, Lescelleur O, Biertho L, Marceau S, Vohl MC, Gaudet D, Bouchard L. ADRB3 gene promoter DNA methylation in blood and visceral adipose tissue is associated with metabolic disturbances in men. Epigenomics. 6: 33-43. PMID 24579945 DOI: 10.2217/epi.13.82  0.92
2014 Guay SP, Brisson D, Lamarche B, Gaudet D, Bouchard L. Epipolymorphisms within lipoprotein genes contribute independently to plasma lipid levels in familial hypercholesterolemia. Epigenetics : Official Journal of the Dna Methylation Society. 9: 718-29. PMID 24504152 DOI: 10.4161/epi.27981  0.92
2014 Ferreira V, Twisk J, Kwikkers K, Aronica E, Brisson D, Methot J, Petry H, Gaudet D. Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPL(S447X)) in a phase II clinical trial of lipoprotein lipase deficiency gene therapy. Human Gene Therapy. 25: 180-8. PMID 24299335 DOI: 10.1089/hum.2013.169  0.92
2014 Tremblay M, Bouhali T, Gaudet D, Brisson D. Genealogical analysis as a new approach for the investigation of drug intolerance heritability. European Journal of Human Genetics : Ejhg. 22: 916-22. PMID 24281370 DOI: 10.1038/ejhg.2013.270  0.92
2014 Braamskamp MJAM, Langslet G, McCrindle BW, Cassiman D, Francis GA, Gagné C, Gaudet D, Morrison KM, Wiegman A, Turner T, Kusters DM, Miller E, Raichlen JS, Wissmar J, Martin PD, et al. Efficacy and safety of rosuvastatin therapy inchildren and adolescents with familial hypercholesterolemia: Results from the CHARONstudy Journal of Clinical Lipidology. DOI: 10.1016/j.jacl.2015.07.011  0.92
2013 Melka MG, Abrahamowicz M, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. Clustering of the metabolic syndrome components in adolescence: role of visceral fat. Plos One. 8: e82368. PMID 24376531 DOI: 10.1371/journal.pone.0082368  0.92
2013 Goodwin K, Syme C, Abrahamowicz M, Leonard GT, Richer L, Perron M, Veillette S, Gaudet D, Paus T, Pausova Z. Routine clinical measures of adiposity as predictors of visceral fat in adolescence: a population-based magnetic resonance imaging study. Plos One. 8: e79896. PMID 24244574 DOI: 10.1371/journal.pone.0079896  0.92
2013 Houde AA, Guay SP, Desgagné V, Hivert MF, Baillargeon JP, St-Pierre J, Perron P, Gaudet D, Brisson D, Bouchard L. Adaptations of placental and cord blood ABCA1 DNA methylation profile to maternal metabolic status. Epigenetics : Official Journal of the Dna Methylation Society. 8: 1289-302. PMID 24113149 DOI: 10.4161/epi.26554  0.92
2013 Kusters DM, Hutten BA, McCrindle BW, Cassiman D, Francis GA, Gagné C, Gaudet D, Morrison KM, Langslet G, Kastelein JJ, Wiegman A. Design and baseline data of a pediatric study with rosuvastatin in familial hypercholesterolemia. Journal of Clinical Lipidology. 7: 408-13. PMID 24079281 DOI: 10.1016/j.jacl.2013.06.010  0.92
2013 Ruchat SM, Houde AA, Voisin G, St-Pierre J, Perron P, Baillargeon JP, Gaudet D, Hivert MF, Brisson D, Bouchard L. Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases. Epigenetics : Official Journal of the Dna Methylation Society. 8: 935-43. PMID 23975224 DOI: 10.4161/epi.25578  0.92
2013 Kaeppel C, Beattie SG, Fronza R, Van Logtenstein R, Salmon F, Schmidt S, Wolf S, Nowrouzi A, Glimm H, Von Kalle C, Petry H, Gaudet D, Schmidt M. A largely random AAV integration profile after LPLD gene therapy Nature Medicine. 19: 889-891. PMID 23770691 DOI: 10.1038/nm.3230  0.92
2013 Brisson D, Perron P, Kahn HS, Gaudet D, Bouchard L. The lipid accumulation product for the early prediction of gestational insulin resistance and glucose dysregulation. Journal of Women's Health (2002). 22: 362-7. PMID 23717842 DOI: 10.1089/jwh.2012.3807  0.92
2013 Guay SP, Brisson D, Lamarche B, Marceau P, Vohl MC, Gaudet D, Bouchard L. DNA methylation variations at CETP and LPL gene promoter loci: new molecular biomarkers associated with blood lipid profile variability. Atherosclerosis. 228: 413-20. PMID 23623643 DOI: 10.1016/j.atherosclerosis.2013.03.033  0.92
2013 Gaudet D, Signorovitch J, Swallow E, Fan L, Tremblay K, Brisson D, Meyers C, Gruenberger JB. Medical resource use and costs associated with chylomicronemia. Journal of Medical Economics. 16: 657-66. PMID 23428107 DOI: 10.3111/13696998.2013.779277  0.92
2013 Gagnon C, Chouinard MC, Laberge L, Brisson D, Gaudet D, Lavoie M, Leclerc N, Mathieu J. Prevalence of lifestyle risk factors in myotonic dystrophy type 1. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 40: 42-7. PMID 23250126  0.92
2013 Cuchel M, Meagher EA, Theron HDT, Blom DJ, Marais AD, Hegele RA, Averna MR, Sirtori CR, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Du Plessi AME, Propert KJ, Sasiela WJ, et al. Effi cacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: A single-arm, open-label, phase 3 study The Lancet. 381: 40-46. PMID 23122768 DOI: 10.1016/S0140-6736(12)61731-0  0.92
2013 Haghighi A, Schwartz DH, Abrahamowicz M, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. Prenatal exposure to maternal cigarette smoking, amygdala volume, and fat intake in adolescence. Jama Psychiatry. 70: 98-105. PMID 22945562 DOI: 10.1001/archgenpsychiatry.2012.1101  0.92
2013 Gaudet D, Méthot J, Déry S, Brisson D, Essiembre C, Tremblay G, Tremblay K, de Wal J, Twisk J, van den Bulk N, Sier-Ferreira V, van Deventer S. Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial. Gene Therapy. 20: 361-9. PMID 22717743 DOI: 10.1038/gt.2012.43  0.92
2012 Guay SP, Voisin G, Brisson D, Munger J, Lamarche B, Gaudet D, Bouchard L. Epigenome-wide analysis in familial hypercholesterolemia identified new loci associated with high-density lipoprotein cholesterol concentration. Epigenomics. 4: 623-39. PMID 23244308 DOI: 10.2217/epi.12.62  0.92
2012 Stein EA, Dufour R, Gagne C, Gaudet D, East C, Donovan JM, Chin W, Tribble DL, McGowan M. Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease. Circulation. 126: 2283-92. PMID 23060426 DOI: 10.1161/CIRCULATIONAHA.112.104125  0.92
2012 Tremblay M, Brisson D, Gaudet D. Association between salivary pH and metabolic syndrome in women: a cross-sectional study. Bmc Oral Health. 12: 40. PMID 22958748 DOI: 10.1186/1472-6831-12-40  0.92
2012 Blackburn P, Lemieux I, Lamarche B, Bergeron J, Perron P, Tremblay G, Gaudet D, Després JP. Angiographically-assessed coronary artery disease associates with HDL particle size in women. Atherosclerosis. 223: 359-64. PMID 22695528 DOI: 10.1016/j.atherosclerosis.2012.05.016  0.92
2012 Gaudet D, Méthot J, Kastelein J. Gene therapy for lipoprotein lipase deficiency. Current Opinion in Lipidology. 23: 310-20. PMID 22691709 DOI: 10.1097/MOL.0b013e3283555a7e  0.72
2012 Stein EA, Gipe D, Bergeron J, Gaudet D, Weiss R, Dufour R, Wu R, Pordy R. Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial. Lancet. 380: 29-36. PMID 22633824 DOI: 10.1016/S0140-6736(12)60771-5  0.92
2012 Carpentier AC, Frisch F, Labbé SM, Gagnon R, de Wal J, Greentree S, Petry H, Twisk J, Brisson D, Gaudet D. Effect of alipogene tiparvovec (AAV1-LPL(S447X)) on postprandial chylomicron metabolism in lipoprotein lipase-deficient patients. The Journal of Clinical Endocrinology and Metabolism. 97: 1635-44. PMID 22438229 DOI: 10.1210/jc.2011-3002  0.92
2012 Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, Zachary AA. Increased frequency of DRB1*11:01 in anti-hydroxymethylglutaryl-coenzyme A reductase-associated autoimmune myopathy. Arthritis Care & Research. 64: 1233-7. PMID 22422616 DOI: 10.1002/acr.21671  0.92
2012 Guay SP, Brisson D, Munger J, Lamarche B, Gaudet D, Bouchard L. ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia. Epigenetics : Official Journal of the Dna Methylation Society. 7: 464-72. PMID 22419126 DOI: 10.4161/epi.19633  0.92
2012 Tremblay M, Loucif Y, Methot J, Brisson D, Gaudet D. Salivary pH as a marker of plasma adiponectin concentrations in Women. Diabetology & Metabolic Syndrome. 4: 4. PMID 22304893 DOI: 10.1186/1758-5996-4-4  0.92
2012 Nikpay M, Å eda O, Tremblay J, Petrovich M, Gaudet D, Kotchen TA, Cowley AW, Hamet P. Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse. Hypertension Research : Official Journal of the Japanese Society of Hypertension. 35: 585-91. PMID 22297481 DOI: 10.1038/hr.2011.233  0.92
2012 Pausova Z, Mahboubi A, Abrahamowicz M, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T. Sex differences in the contributions of visceral and total body fat to blood pressure in adolescence. Hypertension. 59: 572-9. PMID 22291448 DOI: 10.1161/HYPERTENSIONAHA.111.180372  0.92
2012 Méthot J, Brisson D, Gaudet D. On-site management of investigational products and drug delivery systems in conformity with Good Clinical Practices (GCPs). Clinical Trials (London, England). 9: 265-71. PMID 22222352 DOI: 10.1177/1740774511431280  0.92
2012 Melka MG, Bernard M, Mahboubi A, Abrahamowicz M, Paterson AD, Syme C, Lourdusamy A, Schumann G, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. Genome-wide scan for loci of adolescent obesity and their relationship with blood pressure. The Journal of Clinical Endocrinology and Metabolism. 97: E145-50. PMID 22013104 DOI: 10.1210/jc.2011-1801  0.92
2012 Mammen AL, Pak K, Williams EK, Brisson D, Coresh J, Selvin E, Gaudet D. Rarity of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies in statin users, including those with self-limited musculoskeletal side effects. Arthritis Care & Research. 64: 269-72. PMID 21972203 DOI: 10.1002/acr.20662  0.92
2012 Blackburn P, Lemieux I, Lamarche B, Bergeron J, Perron P, Tremblay G, Gaudet D, Després JP. Hypertriglyceridemic waist: a simple clinical phenotype associated with coronary artery disease in women. Metabolism: Clinical and Experimental. 61: 56-64. PMID 21733531 DOI: 10.1016/j.metabol.2011.05.017  0.92
2012 Nikpay M, Šeda O, Tremblay J, Petrovich M, Gaudet D, Kotchen TA, Cowley AW, Hamet P. Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse (Hypertension Research (2012) 35, (585-591;) DOI: 10.1038/hr.2011.233) Hypertension Research. 35: 673. DOI: 10.1038/hr.2012.48  0.92
2011 Tremblay M, Gaudet D, Brisson D. Metabolic syndrome and oral markers of cardiometabolic risk. Journal (Canadian Dental Association). 77: b125. PMID 21975074  0.92
2011 Tremblay K, Méthot J, Brisson D, Gaudet D. Etiology and risk of lactescent plasma and severe hypertriglyceridemia. Journal of Clinical Lipidology. 5: 37-44. PMID 21262505 DOI: 10.1016/j.jacl.2010.11.004  0.92
2011 Loucif Y, Méthot J, Tremblay K, Brisson D, Gaudet D. Contribution of adiponectin to the cardiometabolic risk of postmenopausal women with loss-of-function lipoprotein lipase gene mutations. Menopause (New York, N.Y.). 18: 558-62. PMID 21252727 DOI: 10.1097/gme.0b013e3181fca1d4  0.92
2011 Sirois-Gagnon D, Chamberland A, Perron S, Brisson D, Gaudet D, Laprise C. Association of common polymorphisms in the fractalkine receptor (CX3CR1) with obesity. Obesity (Silver Spring, Md.). 19: 222-7. PMID 20523302 DOI: 10.1038/oby.2010.125  0.92
2010 Brisson D, Méthot J, Tremblay K, Tremblay M, Perron P, Gaudet D. Comparison of the efficacy of fibrates on hypertriglyceridemic phenotypes with different genetic and clinical characteristics. Pharmacogenetics and Genomics. 20: 742-7. PMID 21217359 DOI: 10.1097/FPC.0b013e328340095e  0.92
2010 van der Graaf A, Vissers MN, Gaudet D, Brisson D, Sivapalaratnam S, Roseboom TJ, Jansen AC, Kastelein JJ, Hutten BA. Dyslipidemia of mothers with familial hypercholesterolemia deteriorates lipids in adult offspring. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2673-7. PMID 20864670 DOI: 10.1161/ATVBAHA.110.209064  0.92
2010 Do R, Bailey SD, Paré G, Montpetit A, Desbiens K, Hudson TJ, Yusuf S, Bouchard C, Gaudet D, Pérusse L, Anand S, Vohl MC, Pastinen T, Engert JC. Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels. Circulation. Cardiovascular Genetics. 3: 454-61. PMID 20858904 DOI: 10.1161/CIRCGENETICS.109.917039  0.56
2010 Brisson D, Perron P, Guay SP, Gaudet D, Bouchard L. The "hypertriglyceridemic waist" phenotype and glucose intolerance in pregnancy. Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. 182: E722-5. PMID 20855478 DOI: 10.1503/cmaj.100378  0.92
2010 Gaudet D, de Wal J, Tremblay K, Déry S, van Deventer S, Freidig A, Brisson D, Méthot J. Review of the clinical development of alipogene tiparvovec gene therapy for lipoprotein lipase deficiency. Atherosclerosis. Supplements. 11: 55-60. PMID 20427244 DOI: 10.1016/j.atherosclerosissup.2010.03.004  0.92
2010 Raal FJ, Santos RD, Blom DJ, Marais AD, Charng MJ, Cromwell WC, Lachmann RH, Gaudet D, Tan JL, Chasan-Taber S, Tribble DL, Flaim JD, Crooke ST. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Lancet (London, England). 375: 998-1006. PMID 20227758 DOI: 10.1016/S0140-6736(10)60284-X  0.92
2010 Pausova Z, Abrahamowicz M, Mahboubi A, Syme C, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T. Functional variation in the androgen-receptor gene is associated with visceral adiposity and blood pressure in male adolescents. Hypertension. 55: 706-14. PMID 20083725 DOI: 10.1161/HYPERTENSIONAHA.109.146720  0.92
2010 Orlov SN, Gossard F, Pausova Z, Akimova OA, Tremblay J, Grim CE, Kotchen JM, Kotchen TA, Gaudet D, Cowley AW, Hamet P. Decreased NKCC1 activity in erythrocytes from African Americans with hypertension and dyslipidemia. American Journal of Hypertension. 23: 321-6. PMID 20044742 DOI: 10.1038/ajh.2009.249  0.92
2010 Syme C, Abrahamowicz M, Mahboubi A, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. Prenatal exposure to maternal cigarette smoking and accumulation of intra-abdominal fat during adolescence. Obesity (Silver Spring, Md.). 18: 1021-5. PMID 19851308 DOI: 10.1038/oby.2009.354  0.92
2010 Dastani Z, Pajukanta P, Marcil M, Rudzicz N, Ruel I, Bailey SD, Lee JC, Lemire M, Faith J, Platko J, Rioux J, Hudson TJ, Gaudet D, Engert JC, Genest J. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. European Journal of Human Genetics : Ejhg. 18: 342-7. PMID 19844255 DOI: 10.1038/ejhg.2009.157  0.92
2009 Pausova Z, Syme C, Abrahamowicz M, Xiao Y, Leonard GT, Perron M, Richer L, Veillette S, Smith GD, Seda O, Tremblay J, Hamet P, Gaudet D, Paus T. A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians. Circulation. Cardiovascular Genetics. 2: 260-9. PMID 20031594 DOI: 10.1161/CIRCGENETICS.109.857359  0.92
2009 Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Lorkowski S, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, et al. Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. The Journal of Clinical Investigation. 119: 3597-3612. PMID 19959875 DOI: 10.1172/JCI38433  0.92
2009 Villani AC, Lemire M, Louis E, Silverberg MS, Collette C, Fortin G, Nimmo ER, Renaud Y, Brunet S, Libioulle C, Belaiche J, Bitton A, Gaudet D, Cohen A, Langelier D, et al. Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis. Plos One. 4: e7154. PMID 19784369 DOI: 10.1371/journal.pone.0007154  0.92
2009 Syme C, Abrahamowicz M, Leonard GT, Perron M, Richer L, Veillette S, Xiao Y, Gaudet D, Paus T, Pausova Z. Sex differences in blood pressure and its relationship to body composition and metabolism in adolescence. Archives of Pediatrics & Adolescent Medicine. 163: 818-25. PMID 19736335 DOI: 10.1001/archpediatrics.2009.92  0.92
2009 Paglialunga S, Julien P, Tahiri Y, Cadelis F, Bergeron J, Gaudet D, Cianflone K. Lipoprotein lipase deficiency is associated with elevated acylation stimulating protein plasma levels. Journal of Lipid Research. 50: 1109-19. PMID 19237736 DOI: 10.1194/jlr.M800430-JLR200  0.48
2009 Villani AC, Lemire M, Fortin G, Louis E, Silverberg MS, Collette C, Baba N, Libioulle C, Belaiche J, Bitton A, Gaudet D, Cohen A, Langelier D, Fortin PR, Wither JE, et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nature Genetics. 41: 71-6. PMID 19098911 DOI: 10.1038/ng.285  0.92
2008 Akdim F, Kastelein JJ, Gaudet D. The ENHANCE study and marketing ezetimibe. Jama. 299: 2747; author reply 2. PMID 18560001 DOI: 10.1001/jama.299.23.2747-a  0.36
2008 Syme C, Abrahamowicz M, Leonard GT, Perron M, Pitiot A, Qiu X, Richer L, Totman J, Veillette S, Xiao Y, Gaudet D, Paus T, Pausova Z. Intra-abdominal adiposity and individual components of the metabolic syndrome in adolescence: sex differences and underlying mechanisms. Archives of Pediatrics & Adolescent Medicine. 162: 453-61. PMID 18458192 DOI: 10.1001/archpedi.162.5.453  0.92
2008 Kastelein JJ, Akdim F, Stroes ES, Zwinderman AH, Bots ML, Stalenhoef AF, Visseren FL, Sijbrands EJ, Trip MD, Stein EA, Gaudet D, Duivenvoorden R, Veltri EP, Marais AD, de Groot E, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. The New England Journal of Medicine. 358: 1431-43. PMID 18376000 DOI: 10.1056/NEJMoa0800742  0.92
2008 Do R, Paré G, Montpetit A, Hudson TJ, Gaudet D, Engert JC. K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population. Human Mutation. 29: 689-94. PMID 18350552 DOI: 10.1002/humu.20702  0.92
2008 Seda O, Tremblay J, Gaudet D, Brunelle PL, Gurau A, Merlo E, Pilote L, Orlov SN, Boulva F, Petrovich M, Kotchen TA, Cowley AW, Hamet P. Systematic, genome-wide, sex-specific linkage of cardiovascular traits in French Canadians. Hypertension. 51: 1156-62. PMID 18259002 DOI: 10.1161/HYPERTENSIONAHA.107.105247  0.92
2008 Blackburn P, Lemieux I, Lamarche B, Bergeron J, Perron P, Tremblay G, Gaudet D, Després JP. Type 2 diabetes without the atherogenic metabolic triad does not predict angiographically assessed coronary artery disease in women. Diabetes Care. 31: 170-2. PMID 17934152 DOI: 10.2337/dc07-0272  0.92
2008 Engert JC, Lemire M, Faith J, Brisson D, Fujiwara TM, Roslin NM, Brewer CG, Montpetit A, Darmond-Zwaig C, Renaud Y, Doré C, Bailey SD, Verner A, Tremblay G, St-Pierre J, ... ... Gaudet D, et al. Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population. European Journal of Human Genetics : Ejhg. 16: 105-14. PMID 17805225 DOI: 10.1038/sj.ejhg.5201920  0.92
2008 Bouhali T, Brisson D, St-Pierre J, Tremblay G, Perron P, Laprise C, Vohl MC, Vissers MN, Hutten BA, Després JP, Kastelein JJ, Gaudet D. Low plasma adiponectin exacerbates the risk of premature coronary artery disease in familial hypercholesterolemia. Atherosclerosis. 196: 262-9. PMID 17123536 DOI: 10.1016/j.atherosclerosis.2006.10.035  0.92
2007 Perron P, Brisson D, Santuré M, Blackburn P, Bergeron J, Vohl MC, Després JP, Gaudet D. Apolipoprotein E and lipoprotein lipase gene polymorphisms interaction on the atherogenic combined expression of hypertriglyceridemia and hyperapobetalipoproteinemia phenotypes. Journal of Endocrinological Investigation. 30: 551-7. PMID 17848837 DOI: 10.1007/BF03346348  0.92
2007 Pausova Z, Paus T, Abrahamowicz M, Almerigi J, Arbour N, Bernard M, Gaudet D, Hanzalek P, Hamet P, Evans AC, Kramer M, Laberge L, Leal SM, Leonard G, Lerner J, et al. Genes, maternal smoking, and the offspring brain and body during adolescence: design of the Saguenay Youth Study. Human Brain Mapping. 28: 502-18. PMID 17469173 DOI: 10.1002/hbm.20402  0.92
2007 Pare G, Serre D, Brisson D, Anand SS, Montpetit A, Tremblay G, Engert JC, Hudson TJ, Gaudet D. Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. American Journal of Human Genetics. 80: 673-82. PMID 17357073 DOI: 10.1086/513286  0.92
2007 Winckler W, Weedon MN, Graham RR, McCarroll SA, Purcell S, Almgren P, Tuomi T, Gaudet D, Boström KB, Walker M, Hitman G, Hattersley AT, McCarthy MI, Ardlie KG, Hirschhorn JN, et al. Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes. 56: 685-93. PMID 17327436 DOI: 10.2337/db06-0202  0.92
2007 Campbell CD, Lyon HN, Nemesh J, Drake JA, Tuomi T, Gaudet D, Zhu X, Cooper RS, Ardlie KG, Groop LC, Hirschhorn JN. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. Diabetes. 56: 1460-7. PMID 17325259 DOI: 10.2337/db06-1051  0.92
2007 St-Pierre J, Lemieux I, Perron P, Brisson D, Santuré M, Vohl MC, Després JP, Gaudet D. Relation of the "hypertriglyceridemic waist" phenotype to earlier manifestations of coronary artery disease in patients with glucose intolerance and type 2 diabetes mellitus. The American Journal of Cardiology. 99: 369-73. PMID 17261400 DOI: 10.1016/j.amjcard.2006.08.041  0.92
2007 Robitaille J, Houde A, Lemieux S, Gaudet D, Pérusse L, Vohl MC. The lipoprotein/lipid profile is modulated by a gene-diet interaction effect between polymorphisms in the liver X receptor-alpha and dietary cholesterol intake in French-Canadians. The British Journal of Nutrition. 97: 11-8. PMID 17217555 DOI: 10.1017/S0007114507201722  0.56
2007 Robitaille J, Houde A, Lemieux S, Pérusse L, Gaudet D, Vohl MC. Variants within the muscle and liver isoforms of the carnitine palmitoyltransferase I (CPT1) gene interact with fat intake to modulate indices of obesity in French-Canadians. Journal of Molecular Medicine (Berlin, Germany). 85: 129-37. PMID 17089095 DOI: 10.1007/s00109-006-0116-7  0.56
2007 Hogue JC, Lamarche B, Gaudet D, Tremblay AJ, Després JP, Bergeron J, Gagné C, Couture P. Association of heterozygous familial hypercholesterolemia with smaller HDL particle size. Atherosclerosis. 190: 429-35. PMID 16546193 DOI: 10.1016/j.atherosclerosis.2006.02.023  0.44
2006 Florez JC, Saxena R, Winckler W, Burtt NP, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Ardlie KG, Daly MJ, Altshuler D, Hirschhorn JN, Groop L. The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people. Diabetes. 55: 3620-4. PMID 17130512 DOI: 10.2337/db06-0867  0.92
2006 Lyon HN, Florez JC, Bersaglieri T, Saxena R, Winckler W, Almgren P, Lindblad U, Tuomi T, Gaudet D, Zhu X, Cooper R, Ardlie KG, Daly MJ, Altshuler D, Groop L, et al. Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. Diabetes. 55: 3180-4. PMID 17065359 DOI: 10.2337/db06-0407  0.92
2006 Bailey SD, Loredo-Osti JC, Lepage P, Faith J, Fontaine J, Desbiens KM, Hudson TJ, Bouchard C, Gaudet D, Pérusse L, Vohl MC, Engert JC. Common polymorphisms in the promoter of the visfatin gene (PBEF1) influence plasma insulin levels in a French-Canadian population Diabetes. 55: 2896-2902. PMID 17003359 DOI: 10.2337/db06-0189  0.92
2006 Saxena R, de Bakker PI, Singer K, Mootha V, Burtt N, Hirschhorn JN, Gaudet D, Isomaa B, Daly MJ, Groop L, Ardlie KG, Altshuler D. Comprehensive association testing of common mitochondrial DNA variation in metabolic disease. American Journal of Human Genetics. 79: 54-61. PMID 16773565 DOI: 10.1086/504926  0.92
2006 Sun MW, Lee JY, de Bakker PI, Burtt NP, Almgren P, RÃ¥stam L, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, Altshuler D, Groop L, Florez JC. Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes. Diabetes. 55: 849-55. PMID 16505254 DOI: 10.2337/diabetes.55.03.06.db05-1418  0.92
2006 Florez JC, Wiltshire S, Agapakis CM, Burtt NP, de Bakker PI, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, McCarthy MI, Altshuler D, Groop L. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. Diabetes. 55: 128-35. PMID 16380485 DOI: 10.2337/diabetes.55.1.128  0.92
2006 Hogue JC, Lamarche B, Gaudet D, Tremblay AJ, Després JP, Gagné C, Couture P. Genotype of the mutant LDL receptor allele is associated with LDL particle size heterogeneity in familial hypercholesterolemia. Atherosclerosis. 184: 163-70. PMID 15899484 DOI: 10.1016/j.atherosclerosis.2005.03.027  0.44
2005 Pausova Z, Gaudet D, Gossard F, Bernard M, Kaldunski ML, Jomphe M, Tremblay J, Hudson TJ, Bouchard G, Kotchen TA, Cowley AW, Hamet P. Genome-wide scan for linkage to obesity-associated hypertension in French Canadians. Hypertension. 46: 1280-5. PMID 16216983 DOI: 10.1161/01.HYP.0000188049.23233.fb  0.92
2005 Winckler W, Burtt NP, Holmkvist J, Cervin C, de Bakker PI, Sun M, Almgren P, Tuomi T, Gaudet D, Hudson TJ, Ardlie KG, Daly MJ, Hirschhorn JN, Altshuler D, Groop L. Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes. Diabetes. 54: 2336-42. PMID 16046299 DOI: 10.2337/diabetes.54.8.2336  0.92
2005 Florez JC, Agapakis CM, Burtt NP, Sun M, Almgren P, RÃ¥stam L, Tuomi T, Gaudet D, Hudson TJ, Daly MJ, Ardlie KG, Hirschhorn JN, Groop L, Altshuler D. Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people. Diabetes. 54: 1884-91. PMID 15919813 DOI: 10.2337/diabetes.54.6.1884  0.92
2005 Hamet P, Merlo E, Seda O, Broeckel U, Tremblay J, Kaldunski M, Gaudet D, Bouchard G, Deslauriers B, Gagnon F, Antoniol G, Pausová Z, Labuda M, Jomphe M, Gossard F, et al. Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension. American Journal of Human Genetics. 76: 815-32. PMID 15800845 DOI: 10.1086/430133  0.92
2005 Brisson D, Mathieu J, Vohl MC, Gaudet D. Presence of palmar xanthomas in myotonic dystrophy identifies different patterns of linkage disequilibrium between the apolipoprotein E and myotonic dystrophy protein kinase loci. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 7: 213-5. PMID 15775763 DOI: 10.1097/01.GIM.0000157130.81975.FE  0.92
2005 Winckler W, Graham RR, de Bakker PI, Sun M, Almgren P, Tuomi T, Gaudet D, Hudson TJ, Ardlie KG, Daly MJ, Hirschhorn JN, Groop L, Altshuler D. Association testing of variants in the hepatocyte nuclear factor 4alpha gene with risk of type 2 diabetes in 7,883 people. Diabetes. 54: 886-92. PMID 15734869 DOI: 10.2337/diabetes.54.3.886  0.92
2005 St-Pierre J, Vohl MC, Després JP, Gaudet D, Poirier P. Genetic aspects of diabetes and its cardiovascular complications: Contribution of genetics to risk assessment and clinical management Canadian Journal of Cardiology. 21: 199-209. PMID 15729423  0.92
2005 Grim CE, Cowley AW, Hamet P, Gaudet D, Kaldunski ML, Kotchen JM, Krishnaswami S, Pausova Z, Roman R, Tremblay J, Kotchen TA. Hyperaldosteronism and hypertension: ethnic differences. Hypertension. 45: 766-72. PMID 15699471 DOI: 10.1161/01.HYP.0000154364.00763.d5  0.92
2005 Berthier MT, Houde A, Côté M, Paradis AM, Mauriège P, Bergeron J, Gaudet D, Després JP, Vohl MC. Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men. Journal of Lipid Research. 46: 237-44. PMID 15547300 DOI: 10.1194/jlr.M400135-JLR200  0.92
2004 Berthier MT, Houde A, Paradis AM, Couture P, Gaudet D, Després JP, Vohl MC. Molecular screening of the microsomal triglyceride transfer protein: association between polymorphisms and both abdominal obesity and plasma apolipoprotein B concentration. Journal of Human Genetics. 49: 684-90. PMID 15635487 DOI: 10.1007/s10038-004-0207-7  0.92
2004 Florez JC, Sjögren M, Burtt N, Orho-Melander M, Schayer S, Sun M, Almgren P, Lindblad U, Tuomi T, Gaudet D, Hudson TJ, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, et al. Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes. Diabetes. 53: 3313-8. PMID 15561965 DOI: 10.2337/diabetes.53.12.3313  0.92
2004 Robitaille J, Brouillette C, Houde A, Lemieux S, Pérusse L, Tchernof A, Gaudet D, Vohl MC. Association between the PPARalpha-L162V polymorphism and components of the metabolic syndrome. Journal of Human Genetics. 49: 482-9. PMID 15309680 DOI: 10.1007/s10038-004-0177-9  0.56
2004 Brouillette C, Bossé Y, Pérusse L, Gaudet D, Vohl MC. Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate. Journal of Human Genetics. 49: 424-32. PMID 15249972 DOI: 10.1007/s10038-004-0171-2  0.56
2004 Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D. Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes. 53: 1360-8. PMID 15111507 DOI: 10.2337/diabetes.53.5.1360  0.92
2004 Hogue JC, Lamarche B, Gaudet D, Larivière M, Tremblay AJ, Bergeron J, Lemieux I, Després JP, Gagné C, Couture P. Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia. Journal of Lipid Research. 45: 1077-83. PMID 15026427 DOI: 10.1194/jlr.M300420-JLR200  0.44
2004 Berthier MT, Couture P, Houde A, Paradis AM, Sammak A, Verner A, Deprés JP, Gagné C, Gaudet D, Vohl MC. The c.419-420insA in the MTP gene is associated with abetalipoproteinemia among French-Canadians. Molecular Genetics and Metabolism. 81: 140-3. PMID 14741197 DOI: 10.1016/j.ymgme.2003.11.001  0.92
2003 Ruel IL, Gaudet D, Perron P, Bergeron J, Julien P, Lamarche B. Effect of obesity on HDL and LDL particle sizes in carriers of the null P207L or defective D9N mutation in the lipoprotein lipase gene: the Québec LipD Study. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. 27: 631-7. PMID 12704407 DOI: 10.1038/sj.ijo.0802276  0.92
2003 St-Pierre J, Miller-Felix I, Paradis ME, Bergeron J, Lamarche B, Després JP, Gaudet D, Vohl MC. Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian men. Molecular Genetics and Metabolism. 78: 31-6. PMID 12559845 DOI: 10.1016/S1096-7192(02)00223-8  0.56
2002 Ruel IL, Gaudet D, Perron P, Bergeron J, Julien P, Lamarche B. Characterization of LDL particle size among carriers of a defective or a null mutation in the lipoprotein lipase gene: the Québec LIPD Study. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 1181-6. PMID 12117735 DOI: 10.1161/01.ATV.0000020677.33243.1C  0.92
2002 St-Pierre J, Lemieux I, Vohl MC, Perron P, Tremblay G, Després JP, Gaudet D. Contribution of abdominal obesity and hypertriglyceridemia to impaired fasting glucose and coronary artery disease. The American Journal of Cardiology. 90: 15-8. PMID 12088772 DOI: 10.1016/S0002-9149(02)02378-0  0.92
2002 Pausova Z, Jomphe M, Houde L, Vezina H, Orlov SN, Gossard F, Gaudet D, Tremblay J, Kotchen TA, Cowley AW, Bouchard G, Hamet P. A genealogical study of essential hypertension with and without obesity in French Canadians. Obesity Research. 10: 463-70. PMID 12055322 DOI: 10.1038/oby.2002.64  0.92
2002 Brisson D, Ledoux K, Bossé Y, St-Pierre J, Julien P, Perron P, Hudson TJ, Vohl MC, Gaudet D. Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients. Pharmacogenetics. 12: 313-20. PMID 12042669 DOI: 10.1097/00008571-200206000-00007  0.92
2002 Ruel IL, Gaudet D, Perron P, Pascot A, Després JP, Bergeron J, Julien P, Lamarche B. Determinants of HDL particle size in patients with the null (P207L) or defective (D9N) mutation in the lipoprotein lipase gene: the Québec LipD Study. Atherosclerosis. 162: 269-76. PMID 11996946 DOI: 10.1016/S0021-9150(01)00716-X  0.92
2002 St-Pierre J, Lemieux I, Miller-Felix I, Prud'homme D, Bergeron J, Gaudet D, Nadeau A, Despres JP, Vohl MC. Visceral obesity and hyperinsulinemia modulate the impact of the microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men. Atherosclerosis. 160: 317-24. PMID 11849654  0.56
2001 Hirschhorn JN, Lindgren CM, Daly MJ, Kirby A, Schaffner SF, Burtt NP, Altshuler D, Parker A, Rioux JD, Platko J, Gaudet D, Hudson TJ, Groop LC, Lander ES. Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. American Journal of Human Genetics. 69: 106-16. PMID 11410839 DOI: 10.1086/321287  0.92
2001 Brisson D, Vohl MC, St-Pierre J, Hudson TJ, Gaudet D. Glycerol: a neglected variable in metabolic processes? Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 23: 534-42. PMID 11385633 DOI: 10.1002/bies.1073  0.92
2001 St-Pierre J, Vohl MC, Brisson D, Perron P, Després JP, Hudson TJ, Gaudet D. A sequence variation in the mitochondrial glycerol-3-phosphate dehydrogenase gene is associated with increased plasma glycerol and free fatty acid concentrations among French Canadians. Molecular Genetics and Metabolism. 72: 209-17. PMID 11243726 DOI: 10.1006/mgme.2000.3144  0.92
2000 Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nature Genetics. 26: 76-80. PMID 10973253 DOI: 10.1038/79216  0.92
2000 Vigneault A, Brisson D, Bélanger C, Gaudet D. Community genetics in Eastern Québec: The experience of the Corporation for Research and Action on Hereditary Diseases Community Genetics. 3: 151-155. DOI: 10.1159/000051128  0.36
1999 Gaudet D, Arsenault S, Bélanger C, Hudson T, Perron P, Bernard M, Hamet P. Procedure to protect confidentiality of familial data in community genetics and genomic research. Clinical Genetics. 55: 259-64. PMID 10361987 DOI: 10.1034/j.1399-0004.1999.550408.x  0.92
1999 Gaudet D, Vohl MC, Couture P, Moorjani S, Tremblay G, Perron P, Gagné C, Després JP. Contribution of receptor negative versus receptor defective mutations in the LDL-receptor gene to angiographically assessed coronary artery disease among young (25-49 years) versus middle-aged (50-64 years) men. Atherosclerosis. 143: 153-61. PMID 10208490 DOI: 10.1016/S0021-9150(98)00268-8  0.92
1999 Couture P, Morissette J, Gaudet D, Vohl MC, Gagné C, Bergeron J, Després JP, Simard J. Fine mapping of low-density lipoprotein receptor gene by genetic linkage on chromosome 19p13.1-p13.3 and study of the founder effect of four French Canadian low-density lipoprotein receptor gene mutations. Atherosclerosis. 143: 145-51. PMID 10208489 DOI: 10.1016/S0021-9150(98)00267-6  0.92
1998 Gaudet D, Vohl MC, Julien P, Tremblay G, Perron P, Gagné C, Bergeron J, Moorjani S, Després JP. Relative contribution of low-density lipoprotein receptor and lipoprotein lipase gene mutations to angiographically assessed coronary artery disease among French Canadians. The American Journal of Cardiology. 82: 299-305. PMID 9708657 DOI: 10.1016/S0002-9149(98)00328-2  0.92
1998 Couture P, Brun LD, Szots F, Lelièvre M, Gaudet D, Després JP, Simard J, Lupien PJ, Gagné C. Association of specific LDL receptor gene mutations with differential plasma lipoprotein response to simvastatin in young French Canadians with heterozygous familial hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 18: 1007-12. PMID 9633944 DOI: 10.1161/01.ATV.18.6.1007  0.44
1998 Gaudet D, Vohl MC, Perron P, Tremblay G, Gagné C, Lesiège D, Bergeron J, Moorjani S, Després JP. Relationships of abdominal obesity and hyperinsulinemia to angiographically assessed coronary artery disease in men with known mutations in the LDL receptor gene. Circulation. 97: 871-7. PMID 9521335 DOI: 10.1161/01.CIR.97.9.871  0.92
1997 Julien P, Vohl MC, Gaudet D, Gagné C, Lévesque G, Després JP, Cadelis F, Brun LD, Nadeau A, Murthy MRV. Hyperinsulinemia and abdominal obesity affect the expression of hypertriglyceridemia in heterozygous familial lipoprotein lipase deficiency Diabetes. 46: 2063-2068. PMID 9392497 DOI: 10.2337/diab.46.12.2063  0.92
1997 Vohl MC, Gaudet D, Moorjani S, Tremblay G, Perron P, Gagné C, Lesiège D, Bergeron J, Lupien PJ, Després JP. Comparison of the effect of two low-density lipoprotein receptor class mutations on coronary heart disease among French-Canadian patients heterozygous for familial hypercholesterolaemia. European Journal of Clinical Investigation. 27: 366-73. PMID 9179542 DOI: 10.1046/j.1365-2362.1997.1250669.x  0.92
1995 Pimstone SN, Gagné SE, Gagné C, Lupien PJ, Gaudet D, Williams RR, Kotze M, Reymer PW, Defesche JC, Kastelein JJ. Mutations in the gene for lipoprotein lipase. A cause for low HDL cholesterol levels in individuals heterozygous for familial hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 15: 1704-12. PMID 7583547  0.36
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