Andrew T. Gewirtz - Publications

Biological and Biomedical Sciences Emory University, Atlanta, GA 
Immunology, Virology Biology, Public Health

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yeoh BS, Gewirtz AT, Vijay-Kumar M. Adaptive Immunity Induces Tolerance to Flagellin by Attenuating TLR5 and NLRC4-Mediated Innate Immune Responses. Frontiers in Cellular and Infection Microbiology. 9: 29. PMID 30838179 DOI: 10.3389/fcimb.2019.00029  0.36
2019 Singh V, Yeoh BS, Walker RE, Xiao X, Saha P, Golonka RM, Cai J, Bretin ACA, Cheng X, Liu Q, Flythe MD, Chassaing B, Shearer GC, Patterson AD, Gewirtz AT, et al. Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation. Gut. PMID 30670576 DOI: 10.1136/gutjnl-2018-316250  0.36
2018 Golonka RM, Yeoh BS, Petrick JL, Weinstein SJ, Albanes D, Gewirtz AT, McGlynn KA, Vijay-Kumar M. Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort. Jnci Cancer Spectrum. 2: pky083. PMID 30815627 DOI: 10.1093/jncics/pky083  0.36
2018 Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, ... ... Gewirtz AT, et al. Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer. Cell. 175: 679-694.e22. PMID 30340040 DOI: 10.1016/j.cell.2018.09.004  0.36
2017 Chassaing B, Vijay-Kumar M, Gewirtz AT. How diet can impact gut microbiota to promote or endanger health. Current Opinion in Gastroenterology. 33: 417-421. PMID 29019865 DOI: 10.1097/MOG.0000000000000401  0.36
2016 Etienne-Mesmin L, Vijay-Kumar M, Gewirtz AT, Chassaing B. Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet-Induced Liver Disease. Cellular and Molecular Gastroenterology and Hepatology. 2: 584-604. PMID 28090564 DOI: 10.1016/j.jcmgh.2016.04.007  0.36
2016 Reichardt F, Chassaing B, Nezami BG, Li G, Tabatabavakili S, Mwangi S, Uppal K, Liang B, Vijay-Kumar M, Jones D, Gewirtz AT, Srinivasan S. Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and LPS-induced TLR4 signaling. The Journal of Physiology. PMID 28000223 DOI: 10.1113/JP273269  0.36
2016 Li JY, Chassaing B, Tyagi AM, Vaccaro C, Luo T, Adams J, Darby TM, Weitzmann MN, Mulle JG, Gewirtz AT, Jones RM, Pacifici R. Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. The Journal of Clinical Investigation. PMID 27111232 DOI: 10.1172/JCI86062  0.36
2015 Singh V, Chassaing B, Zhang L, San Yeoh B, Xiao X, Kumar M, Baker MT, Cai J, Walker R, Borkowski K, Harvatine KJ, Singh N, Shearer GC, Ntambi JM, Joe B, ... ... Gewirtz AT, et al. Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice. Cell Metabolism. PMID 26525535 DOI: 10.1016/j.cmet.2015.09.028  0.36
2015 Chassaing B, Miles-Brown J, Pellizzon M, Ulman E, Ricci M, Zhang L, Patterson AD, Vijay-Kumar M, Gewirtz AT. Lack of soluble fiber drives diet-induced adiposity in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 309: G528-41. PMID 26185332 DOI: 10.1152/ajpgi.00172.2015  0.36
2015 Singh V, Yeoh BS, Carvalho F, Gewirtz AT, Vijay-Kumar M. Proneness of TLR5 Deficient Mice to Develop Colitis is Microbiota Dependent. Gut Microbes. 0. PMID 26067589 DOI: 10.1080/19490976.2015.1060390  0.36
2014 Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT. Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science (New York, N.Y.). 346: 861-5. PMID 25395539 DOI: 10.1126/science.1256999  0.36
2013 Cullender TC, Chassaing B, Janzon A, Kumar K, Muller CE, Werner JJ, Angenent LT, Bell ME, Hay AG, Peterson DA, Walter J, Vijay-Kumar M, Gewirtz AT, Ley RE. Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host & Microbe. 14: 571-81. PMID 24237702 DOI: 10.1016/j.chom.2013.10.009  0.36
2012 Chassaing B, Aitken JD, Gewirtz AT, Vijay-Kumar M. Gut microbiota drives metabolic disease in immunologically altered mice. Advances in Immunology. 116: 93-112. PMID 23063074 DOI: 10.1016/B978-0-12-394300-2.00003-X  0.36
2012 Chassaing B, Srinivasan G, Delgado MA, Young AN, Gewirtz AT, Vijay-Kumar M. Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. Plos One. 7: e44328. PMID 22957064 DOI: 10.1371/journal.pone.0044328  0.36
2012 Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassaing B, Walters WA, González A, Clemente JC, Cullender TC, Barnich N, Darfeuille-Michaud A, Vijay-Kumar M, ... ... Gewirtz AT, et al. Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host & Microbe. 12: 139-52. PMID 22863420 DOI: 10.1016/j.chom.2012.07.004  0.36
2012 Srinivasan G, Aitken JD, Zhang B, Carvalho FA, Chassaing B, Shashidharamurthy R, Borregaard N, Jones DP, Gewirtz AT, Vijay-Kumar M. Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. Journal of Immunology (Baltimore, Md. : 1950). 189: 1911-9. PMID 22786765 DOI: 10.4049/jimmunol.1200892  0.36
2012 Anitha M, Vijay-Kumar M, Sitaraman SV, Gewirtz AT, Srinivasan S. Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling. Gastroenterology. 143: 1006-16.e4. PMID 22732731 DOI: 10.1053/j.gastro.2012.06.034  0.36
2012 Vijay-Kumar M, Gewirtz AT. Is predisposition to NAFLD and obesity communicable? Cell Metabolism. 15: 419-20. PMID 22482724 DOI: 10.1016/j.cmet.2012.03.013  0.36
2012 Carvalho FA, Aitken JD, Vijay-Kumar M, Gewirtz AT. Toll-like receptor-gut microbiota interactions: perturb at your own risk! Annual Review of Physiology. 74: 177-98. PMID 22035346 DOI: 10.1146/annurev-physiol-020911-153330  0.36
2012 Frias AH, Jones RM, Fifadara NH, Vijay-Kumar M, Gewirtz AT. Rotavirus-induced IFN-β promotes anti-viral signaling and apoptosis that modulate viral replication in intestinal epithelial cells. Innate Immunity. 18: 294-306. PMID 21733977 DOI: 10.1177/1753425911401930  0.36
2012 Carvalho FA, Nalbantoglu I, Ortega-Fernandez S, Aitken JD, Su Y, Koren O, Walters WA, Knight R, Ley RE, Vijay-Kumar M, Gewirtz AT. Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut. 61: 373-84. PMID 21646247 DOI: 10.1136/gut.2011.240556  0.36
2011 Vijay-Kumar M, Aitken JD, Carvalho FA, Ziegler TR, Gewirtz AT, Ganji V. Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice. Journal of Inflammation (London, England). 8: 2. PMID 21314942 DOI: 10.1186/1476-9255-8-2  0.36
2011 Jones RM, Sloane VM, Wu H, Luo L, Kumar A, Kumar MV, Gewirtz AT, Neish AS. Flagellin administration protects gut mucosal tissue from irradiation-induced apoptosis via MKP-7 activity. Gut. 60: 648-57. PMID 21199832 DOI: 10.1136/gut.2010.223891  0.36
2010 Vijay-Kumar M, Carvalho FA, Aitken JD, Fifadara NH, Gewirtz AT. TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. European Journal of Immunology. 40: 3528-34. PMID 21072873 DOI: 10.1002/eji.201040421  0.36
2010 Titanji K, Velu V, Chennareddi L, Vijay-Kumar M, Gewirtz AT, Freeman GJ, Amara RR. Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. The Journal of Clinical Investigation. 120: 3878-90. PMID 20972331 DOI: 10.1172/JCI43271  0.36
2010 Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, Sitaraman SV, Knight R, Ley RE, Gewirtz AT. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science (New York, N.Y.). 328: 228-31. PMID 20203013 DOI: 10.1126/science.1179721  0.36
2009 Onyeagocha C, Hossain MS, Kumar A, Jones RM, Roback J, Gewirtz AT. Latent cytomegalovirus infection exacerbates experimental colitis. The American Journal of Pathology. 175: 2034-42. PMID 19815702 DOI: 10.2353/ajpath.2009.090471  0.36
2009 Theiss AL, Vijay-Kumar M, Obertone TS, Jones DP, Hansen JM, Gewirtz AT, Merlin D, Sitaraman SV. Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice. Gastroenterology. 137: 199-208, 208.e1-6. PMID 19327358 DOI: 10.1053/j.gastro.2009.03.033  0.36
2009 Garg P, Vijay-Kumar M, Wang L, Gewirtz AT, Merlin D, Sitaraman SV. Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G175-84. PMID 19171847 DOI: 10.1152/ajpgi.90454.2008  0.36
2009 Vijay-Kumar M, Gewirtz AT. Role of flagellin in Crohn's disease: emblematic of the progress and enigmas in understanding inflammatory bowel disease. Inflammatory Bowel Diseases. 15: 789-95. PMID 19107795 DOI: 10.1002/ibd.20734  0.36
2008 Chandrasekharan B, Bala V, Kolachala VL, Vijay-Kumar M, Jones D, Gewirtz AT, Sitaraman SV, Srinivasan S. Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis. Plos One. 3: e3304. PMID 18836554 DOI: 10.1371/journal.pone.0003304  0.36
2008 Vijay-Kumar M, Gewirtz AT. Guardians of the gut: newly appreciated role of epithelial toll-like receptors in protecting the intestine. Gastroenterology. 135: 351-4. PMID 18619968 DOI: 10.1053/j.gastro.2008.06.064  0.36
2008 Vijay-Kumar M, Aitken JD, Sanders CJ, Frias A, Sloane VM, Xu J, Neish AS, Rojas M, Gewirtz AT. Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. Journal of Immunology (Baltimore, Md. : 1950). 180: 8280-5. PMID 18523294  0.36
2008 Vijay-Kumar M, Aitken JD, Kumar A, Neish AS, Uematsu S, Akira S, Gewirtz AT. Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease Infection and Immunity. 76: 1276-1281. PMID 18195036 DOI: 10.1128/IAI.01491-07  0.36
2008 Vijay-Kumar M, Aitken JD, Gewirtz AT. Toll like receptor-5: protecting the gut from enteric microbes. Seminars in Immunopathology. 30: 11-21. PMID 18066550 DOI: 10.1007/s00281-007-0100-5  0.36
2007 Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT. Deletion of TLR5 results in spontaneous colitis in mice. The Journal of Clinical Investigation. 117: 3909-21. PMID 18008007 DOI: 10.1172/JCI33084  0.36
2007 Vijay-Kumar M, Wu H, Aitken J, Kolachala VL, Neish AS, Sitaraman SV, Gewirtz AT. Activation of toll-like receptor 3 protects against DSS-induced acute colitis. Inflammatory Bowel Diseases. 13: 856-64. PMID 17393379 DOI: 10.1002/ibd.20142  0.36
2006 Vijay-Kumar M, Wu H, Jones R, Grant G, Babbin B, King TP, Kelly D, Gewirtz AT, Neish AS. Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. The American Journal of Pathology. 169: 1686-700. PMID 17071592 DOI: 10.2353/ajpath.2006.060345  0.36
2006 Garg P, Rojas M, Ravi A, Bockbrader K, Epstein S, Vijay-Kumar M, Gewirtz AT, Merlin D, Sitaraman SV. Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: contrasting role of gelatinases in the pathogenesis of colitis. Journal of Immunology (Baltimore, Md. : 1950). 177: 4103-12. PMID 16951375  0.36
2006 Gewirtz AT, Vijay-Kumar M, Brant SR, Duerr RH, Nicolae DL, Cho JH. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G1157-63. PMID 16439468 DOI: 10.1152/ajpgi.00544.2005  0.36
2005 Castaneda FE, Walia B, Vijay-Kumar M, Patel NR, Roser S, Kolachala VL, Rojas M, Wang L, Oprea G, Garg P, Gewirtz AT, Roman J, Merlin D, Sitaraman SV. Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Gastroenterology. 129: 1991-2008. PMID 16344067 DOI: 10.1053/j.gastro.2005.09.017  0.36
2005 Vijay-Kumar M, Gentsch JR, Kaiser WJ, Borregaard N, Offermann MK, Neish AS, Gewirtz AT. Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus. Journal of Immunology (Baltimore, Md. : 1950). 174: 6322-31. PMID 15879132  0.36
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