| Year |
Citation |
Score |
| 2024 |
D'Souza NC, Aiken JA, Hoffman EG, Atherley SC, Champsi S, Aleali N, Shakeri D, El-Zahed M, Akbarian N, Nejad-Mansouri M, Bavani PZ, Liggins RL, Chan O, Riddell MC. Evaluating the effectiveness of a novel somatostatin receptor 2 antagonist, ZT-01, for hypoglycemia prevention in a rodent model of type 2 diabetes. Frontiers in Pharmacology. 15: 1302015. PMID 38510652 DOI: 10.3389/fphar.2024.1302015 |
0.437 |
|
| 2023 |
Su G, Farhat R, Laxman AK, Chapman-Natewa K, Nelson IE, Chan O. Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia. Diabetes. PMID 37216640 DOI: 10.2337/db22-0902 |
0.324 |
|
| 2022 |
Farhat R, Aiken J, D'Souza NC, Appadurai D, Hull G, Simonson E, Liggins RT, Riddell MC, Chan O. ZT-01: A novel somatostatin receptor 2 antagonist for restoring the glucagon response to hypoglycaemia in type 1 diabetes. Diabetes, Obesity & Metabolism. 24: 908-917. PMID 35060297 DOI: 10.1111/dom.14652 |
0.404 |
|
| 2021 |
Hoffman EG, Jahngiriesmaili M, Mandel ER, Greenberg C, Aiken J, D'Souza NC, Pasieka A, Teich T, Chan O, Liggins R, Riddell MC. Somatostatin Receptor Antagonism Reverses Glucagon Counterregulatory Failure in Recurrently Hypoglycemic Male Rats. Endocrinology. PMID 34477204 DOI: 10.1210/endocr/bqab189 |
0.437 |
|
| 2021 |
Farhat R, de Santana-Van Vliet E, Su G, Neely L, Benally T, Chan O. Carvedilol prevents impairment of the counterregulatory response in recurrently hypoglycaemic diabetic rats. Endocrinology, Diabetes & Metabolism. 4: e00226. PMID 33855225 DOI: 10.1002/edm2.226 |
0.438 |
|
| 2021 |
Sejling AS, Wang P, Zhu W, Farhat R, Knight N, Appadurai D, Chan O. Repeated Activation of Noradrenergic Receptors in the Ventromedial Hypothalamus Suppresses the Response to Hypoglycemia. Endocrinology. 162. PMID 33570117 DOI: 10.1210/endocr/bqaa241 |
0.385 |
|
| 2021 |
Sejling AS, Wang P, Zhu W, Farhat R, Knight N, Appadurai D, Chan O. Repeated Activation of Noradrenergic Receptors in the Ventromedial Hypothalamus Suppresses the Response to Hypoglycemia. Endocrinology. 162. PMID 33508114 DOI: 10.1210/endocr/bqaa241 |
0.385 |
|
| 2020 |
Sejling AS, Wang P, Zhu W, Farhat R, Knight N, Appadurai D, Chan O. Repeated Activation of Noradrenergic Receptors in the Ventromedial Hypothalamus Suppresses the Response to Hypoglycemia. Endocrinology. PMID 33367607 DOI: 10.1210/endocr/bqaa241 |
0.429 |
|
| 2020 |
Lin YK, Groat D, Chan O, Hung M, Sharma A, Varner MW, Gouripeddi R, Facelli JC, Fisher SJ. Associations between the Time in Hypoglycemia and Hypoglycemia Awareness Status in Type 1 Diabetes Patients Using Continuous Glucose Monitoring Systems. Diabetes Technology & Therapeutics. PMID 32267773 DOI: 10.1089/dia.2020.0016 |
0.371 |
|
| 2020 |
Lin YK, Groat D, Chan O, Hung M, Sharma A, Varner MW, Gouripeddi R, Facelli JC, Fisher SJ. Alarm Settings of Continuous Glucose Monitoring Systems and Associations to Glucose Outcomes in Type 1 Diabetes. Journal of the Endocrine Society. 4: bvz005. PMID 31993548 DOI: 10.1210/jendso/bvz005 |
0.405 |
|
| 2020 |
Aiken J, D’Souza NC, Simonson E, Farhat R, Chan O, Liggins R, Riddell M. 9-LB: Novel Somatostatin Receptor 2 Antagonist ZT-01 Prevents Hypoglycemia Onset in STZ-Diabetic Rats by Improving Glucagon Secretion Diabetes. 69. DOI: 10.2337/Db20-9-Lb |
0.589 |
|
| 2020 |
Farhat R, Simonson E, Riddell M, Liggins R, Chan O. 12-LB: Subcutaneous Administration of the Novel Somatostatin Receptor 2 Antagonist ZT-01 Restores the Glucagon Response to Hypoglycemia in STZ-Diabetic Rats to Normal Levels Diabetes. 69. DOI: 10.2337/Db20-12-Lb |
0.498 |
|
| 2019 |
Lin YK, Chan O, Fisher SJ. RE: RE: Impaired Awareness of Hypoglycemia Continues to be a Risk Factor for Severe Hypoglycemia Despite the use of Continuous Glucose Monitoring System in Type 1 Diabetes. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 25: 1080-1081. PMID 31613158 DOI: 10.4158/1934-2403-25.10.1080 |
0.36 |
|
| 2019 |
Ren H, Vieira-de-Abreu A, Yan S, Reilly AM, Chan O, Accili D. Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-expressing Neurons. Endocrinology. PMID 31199472 DOI: 10.1210/En.2019-00341 |
0.334 |
|
| 2019 |
Shah M, Addison A, Wang P, Zhu W, Chan O. Recurrent Glucose Deprivation Leads to the Preferential Use of Lactate by Neurons in the Ventromedial Hypothalamus. American Journal of Physiology. Endocrinology and Metabolism. PMID 30888861 DOI: 10.1152/ajpendo.00468.2018 |
0.374 |
|
| 2019 |
Lin YK, Hung M, Sharma A, Chan O, Varner MW, Staskus G, Fisher SJ. IMPAIRED AWARENESS OF HYPOGLYCEMIA CONTINUES TO BE A RISK FACTOR FOR SEVERE HYPOGLYCEMIA DESPITE THE USE OF CONTINUOUS GLUCOSE MONITORING SYSTEM IN TYPE 1 DIABETES. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. PMID 30865520 DOI: 10.4158/EP-2018-0527 |
0.337 |
|
| 2019 |
Farhat R, Su G, Sejling AS, Knight N, Fisher SJ, Chan O. Carvedilol prevents counterregulatory failure and impaired hypoglycaemia awareness in non-diabetic recurrently hypoglycaemic rats. Diabetologia. PMID 30627753 DOI: 10.1007/s00125-018-4802-0 |
0.324 |
|
| 2019 |
FARHAT R, CHAN O, SU G, VAN VLIET EDS. 117-OR: Carvedilol Prevents Impairment of the Counterregulatory Response in Recurrently Hypoglycemic Diabetic Rats Diabetes. 68: 117-OR. DOI: 10.2337/DB19-117-OR |
0.463 |
|
| 2018 |
Hammadi S, Chan O, Abdellali M, Medjerab M, Agoun H, Bellahreche Z, Khalkhal A, Dahmani Y. Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetic gerbils (Gerbillus gerbillus). International Journal of Experimental Pathology. 99: 172-179. PMID 30256482 DOI: 10.1111/iep.12284 |
0.405 |
|
| 2018 |
Agrawal R, Vieira-de-Abreu A, Durupt G, Taylor C, Chan O, Fisher SJ. Insulin regulates GLUT4 in the Ventromedial Hypothalamus to Restore the Sympathoadrenal Response to Hypoglycemia in Diabetic Rats. American Journal of Physiology. Endocrinology and Metabolism. PMID 30226996 DOI: 10.1152/ajpendo.00324.2018 |
0.584 |
|
| 2018 |
Belfort-DeAguiar RD, Gallezot JD, Hwang JJ, Elshafie A, Yeckel CW, Chan O, Carson RE, Ding YS, Sherwin RS. Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia. The Journal of Clinical Endocrinology and Metabolism. PMID 29590401 DOI: 10.1210/Jc.2017-02717 |
0.406 |
|
| 2018 |
Riddell M, Jahangiriesmaili M, Mandel ER, Greenberg CA, Pasieka AM, Teich T, Chan O, Liggins RT. Somatostatin Receptor II Antagonism Improves Glucagon Counterregulatory Responses to Recurrent Hypoglycemia in Male Sprague-Dawley Rats Diabetes. 67. DOI: 10.2337/Db18-394-P |
0.453 |
|
| 2018 |
Hammadi S, Chan O, Abdellali M, Agoun H, Bellahreche Z, Khalkhal A, Dahmani Y. Hypercortisolemia In the streptozotocin-diabetic Gerbils ( Gerbillus Gerbillus ) Annales D'Endocrinologie. 79: 189. DOI: 10.1016/J.ANDO.2018.04.012 |
0.36 |
|
| 2017 |
Chowdhury GMI, Wang P, Ciardi A, Mamillapalli R, Johnson J, Zhu W, Eid T, Behar K, Chan O. Impaired Glutamatergic Neurotransmission in the VMH May Contribute to Defective Counterregulation in Recurrently Hypoglycemic Rats. Diabetes. PMID 28416628 DOI: 10.2337/Db16-1589 |
0.316 |
|
| 2016 |
Yue JT, Abraham MA, Bauer PV, LaPierre MP, Wang P, Duca FA, Filippi BM, Chan O, Lam TK. Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity. Nature Communications. 7: 13501. PMID 27874011 DOI: 10.1038/Ncomms13501 |
0.451 |
|
| 2015 |
Fan X, Chan O, Ding Y, Zhu W, Mastaitis J, Sherwin R. Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats. Diabetes. PMID 26130763 DOI: 10.2337/Db15-0022 |
0.611 |
|
| 2015 |
Kudrick N, Chan O, La Gamma EF, Kim JL, Tank AW, Sterling C, Nankova BB. Posttranscriptional regulation of adrenal TH gene expression contributes to the maladaptive responses triggered by insulin-induced recurrent hypoglycemia. Physiological Reports. 3. PMID 25713330 DOI: 10.14814/Phy2.12307 |
0.495 |
|
| 2014 |
LaGamma EF, Kirtok N, Chan O, Nankova BB. Partial blockade of nicotinic acetylcholine receptors improves the counterregulatory response to hypoglycemia in recurrently hypoglycemic rats American Journal of Physiology - Endocrinology and Metabolism. 307: E580-E588. PMID 25117409 DOI: 10.1152/Ajpendo.00237.2014 |
0.506 |
|
| 2014 |
Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S. Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 11876-81. PMID 25071172 DOI: 10.1073/Pnas.1406000111 |
0.457 |
|
| 2014 |
Chan O, Sherwin RS. Is there cross talk between portal and hypothalamic glucose-sensing circuits? Diabetes. 63: 2617-9. PMID 25060894 DOI: 10.2337/Db14-0755 |
0.332 |
|
| 2013 |
Chan O, Sherwin R. Influence of VMH fuel sensing on hypoglycemic responses Trends in Endocrinology and Metabolism. 24: 616-624. PMID 24063974 DOI: 10.1016/J.Tem.2013.08.005 |
0.512 |
|
| 2013 |
Chan O, Paranjape SA, Horblitt A, Zhu W, Sherwin RS. Lactate-induced release of GABA in the ventromedial hypothalamus contributes to counterregulatory failure in recurrent hypoglycemia and diabetes. Diabetes. 62: 4239-46. PMID 23939392 DOI: 10.2337/Db13-0770 |
0.436 |
|
| 2013 |
Paranjape SA, Chan O, Zhu W, Acharya NK, Rogers AM, Hajnal A, Sherwin RS. Improvement in hepatic insulin sensitivity after Roux-en-Y gastric bypass in a rat model of obesity is partially mediated via hypothalamic insulin action. Diabetologia. 56: 2055-8. PMID 23783353 DOI: 10.1007/S00125-013-2952-7 |
0.504 |
|
| 2013 |
Page KA, Chan O, Arora J, Belfort-Deaguiar R, Dzuira J, Roehmholdt B, Cline GW, Naik S, Sinha R, Constable RT, Sherwin RS. Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. Jama. 309: 63-70. PMID 23280226 DOI: 10.1001/Jama.2012.116975 |
0.43 |
|
| 2012 |
Chan O, Sherwin RS. Hypothalamic regulation of glucose-stimulated insulin secretion. Diabetes. 61: 564-5. PMID 22354931 DOI: 10.2337/Db11-1846 |
0.482 |
|
| 2011 |
Szepietowska B, Zhu W, Chan O, Horblitt A, Dziura J, Sherwin RS. Modulation of β-adrenergic receptors in the ventromedial hypothalamus influences counterregulatory responses to hypoglycemia. Diabetes. 60: 3154-8. PMID 22013013 DOI: 10.2337/Db11-0432 |
0.522 |
|
| 2011 |
Paranjape SA, Chan O, Zhu W, Horblitt AM, Grillo CA, Wilson S, Reagan L, Sherwin RS. Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain. American Journal of Physiology. Endocrinology and Metabolism. 301: E978-83. PMID 21828334 DOI: 10.1152/Ajpendo.00304.2011 |
0.532 |
|
| 2011 |
Chan O, Paranjape S, Czyzyk D, Horblitt A, Zhu W, Ding Y, Fan X, Seashore M, Sherwin R. Increased GABAergic output in the ventromedial hypothalamus contributes to impaired hypoglycemic counterregulation in diabetic rats Diabetes. 60: 1582-1589. PMID 21411513 DOI: 10.2337/Db10-1579 |
0.558 |
|
| 2010 |
Zhu W, Czyzyk D, Paranjape SA, Zhou L, Horblitt A, Szabó G, Seashore MR, Sherwin RS, Chan O. Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia. American Journal of Physiology. Endocrinology and Metabolism. 298: E971-7. PMID 20304763 DOI: 10.1152/Ajpendo.00749.2009 |
0.449 |
|
| 2010 |
Paranjape SA, Chan O, Zhu W, Horblitt AM, McNay EC, Cresswell JA, Bogan JS, McCrimmon RJ, Sherwin RS. Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo. Diabetes. 59: 1521-7. PMID 20299468 DOI: 10.2337/Db10-0014 |
0.511 |
|
| 2008 |
Inouye KE, Chan O, Yue JT, Andrews M, Li Q, Matthews SG, Vranic M. The effect of long-term insulin treatment with and without antecedent hypoglycemia on neuropeptide and corticosteroid receptor expression in the brains of diabetic rats. Brain Research Bulletin. 77: 149-57. PMID 18672033 DOI: 10.1016/J.Brainresbull.2008.07.001 |
0.719 |
|
| 2008 |
Chan O, Cheng H, Herzog R, Czyzyk D, Zhu W, Wang A, McCrimmon RJ, Seashore MR, Sherwin RS. Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia. Diabetes. 57: 1363-70. PMID 18375441 DOI: 10.2337/Db07-1559 |
0.386 |
|
| 2008 |
Herzog RI, Chan O, Yu S, Dziura J, McNay EC, Sherwin RS. Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration. Endocrinology. 149: 1499-504. PMID 18187548 DOI: 10.1210/En.2007-1252 |
0.455 |
|
| 2007 |
Cheng H, Zhou L, Zhu W, Wang A, Tang C, Chan O, Sherwin RS, McCrimmon RJ. Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation. American Journal of Physiology. Endocrinology and Metabolism. 293: E705-12. PMID 17578887 DOI: 10.1152/Ajpendo.00136.2007 |
0.487 |
|
| 2007 |
Chan O, Lawson M, Zhu W, Beverly JL, Sherwin RS. ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia. Diabetes. 56: 1120-6. PMID 17251273 DOI: 10.2337/Db06-1102 |
0.31 |
|
| 2006 |
McCrimmon RJ, Fan X, Cheng H, McNay E, Chan O, Shaw M, Ding Y, Zhu W, Sherwin RS. Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation. Diabetes. 55: 1755-60. PMID 16731839 DOI: 10.2337/Db05-1359 |
0.521 |
|
| 2006 |
Chan O, Zhu W, Ding Y, McCrimmon RJ, Sherwin RS. Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia. Diabetes. 55: 1080-7. PMID 16567532 DOI: 10.2337/Diabetes.55.04.06.Db05-0958 |
0.494 |
|
| 2006 |
Inouye KE, Yue JT, Chan O, Kim T, Akirav EM, Park E, Riddell MC, Burdett E, Matthews SG, Vranic M. Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats. Endocrinology. 147: 1860-70. PMID 16396986 DOI: 10.1210/En.2005-1040 |
0.73 |
|
| 2005 |
McCrimmon RJ, Evans ML, Fan X, McNay EC, Chan O, Ding Y, Zhu W, Gram DX, Sherwin RS. Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats. Diabetes. 54: 3169-74. PMID 16249441 DOI: 10.2337/Diabetes.54.11.3169 |
0.457 |
|
| 2005 |
Park E, Chan O, Li Q, Kiraly M, Matthews SG, Vranic M, Riddell MC. Changes in basal hypothalamo-pituitary-adrenal activity during exercise training are centrally mediated. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R1360-71. PMID 16221981 DOI: 10.1152/Ajpregu.00103.2005 |
0.558 |
|
| 2005 |
Chan O, Inouye K, Akirav EM, Park E, Riddell MC, Matthews SG, Vranic M. Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R235-46. PMID 15774766 DOI: 10.1152/Ajpregu.00674.2004 |
0.749 |
|
| 2005 |
Chan O, Inouye K, Akirav E, Park E, Riddell MC, Vranic M, Matthews SG. Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses. Endocrinology. 146: 1382-90. PMID 15564337 DOI: 10.1210/En.2004-0607 |
0.72 |
|
| 2005 |
Inouye KE, Chan O, Yue JT, Matthews SG, Vranic M. Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis. American Journal of Physiology. Endocrinology and Metabolism. 288: E422-9. PMID 15494609 DOI: 10.1152/Ajpendo.00389.2004 |
0.678 |
|
| 2004 |
Akirav EM, Chan O, Inouye K, Riddell MC, Matthews SG, Vranic M. Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats. Metabolism: Clinical and Experimental. 53: 1558-64. PMID 15562400 DOI: 10.1016/J.Metabol.2004.06.024 |
0.663 |
|
| 2003 |
Park E, Chan O, Chung R, Matthews SG, Vranic M, Hood DA, Riddell MC. BASAL GLUCOCORTICOID ACTIVITY DECREASES WITH TRAINING AND CORRELATES NEGATIVELY WITH MUSCLE CYTOCHROME C OXIDASE ACTIVITY Medicine & Science in Sports & Exercise. 35: S121. DOI: 10.1097/00005768-200305001-00660 |
0.479 |
|
| 2002 |
Chan O, Chan S, Inouye K, Shum K, Matthews SG, Vranic M. Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses. Diabetes. 51: 1681-9. PMID 12031953 DOI: 10.2337/Diabetes.51.6.1681 |
0.745 |
|
| 2002 |
Inouye K, Shum K, Chan O, Mathoo J, Matthews SG, Vranic M. Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats. American Journal of Physiology. Endocrinology and Metabolism. 282: E1369-79. PMID 12006368 DOI: 10.1152/Ajpendo.00480.2001 |
0.736 |
|
| 2002 |
Chan O, Inouye K, Vranic M, Matthews SG. Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity Endocrinology. 143: 1761-1768. PMID 11956158 DOI: 10.1210/Endo.143.5.8809 |
0.715 |
|
| 2001 |
Chan O, Chan S, Inouye K, Vranic M, Matthews SG. Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: Effects of insulin treatment Endocrinology. 142: 4872-4879. PMID 11606455 DOI: 10.1210/Endo.142.11.8474 |
0.727 |
|
| 2001 |
Shum K, Inouye K, Chan O, Mathoo J, Bilinski D, Matthews SG, Vranic M. Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation. American Journal of Physiology. Endocrinology and Metabolism. 281: E455-65. PMID 11500300 DOI: 10.1152/Ajpendo.2001.281.3.E455 |
0.658 |
|
| 2000 |
Niwa M, Rashid S, Shum K, Mathoo JM, Chan O, Tchipashvili V, Kawamori R, Vranic M, Giacca A. Effect of JTT-501 on net hepatic glucose balance and peripheral glucose uptake in alloxan-induced diabetic dogs. Metabolism: Clinical and Experimental. 49: 862-7. PMID 10909996 DOI: 10.1053/Meta.2000.6752 |
0.651 |
|
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